Digital Commons Network^™

Sex Differences In Clinical Characteristics, Treatment, And Outcomes Of Cardiovascular Disease: Kenya Heart Registry Analysis, Lilian Mbau, Martha Gulati, Mzee Ngunga, Jasmit Shah, Felix Barasa, Jeilan Mohamed, Anders Barasa, Bernard Gitura, Harun Otieno, Etienne Amendezo

Internal Medicine, East Africa

Background Cardiovascular disease is the leading cause of death globally, with approximately 80% of these deaths occurring in low- and middle-income countries. Sex differences in cardiovascular disease are well described in high-income countries but limited in low- and middle-income countries.

Objectives This study sought to evaluate the sex differences in clinical presentation, cardiovascular risk profile, diagnosis, treatment, and outcomes among patients in the Kenya Heart Registry.

Methods Data were prospectively collected from 3 tertiary hospitals, including patients with heart failure, acute coronary syndrome, venous thromboembolism, and atrial fibrillation. Primary outcomes were in-hospital and 6-month mortality, as well as sex-specific differences …

Nh State Shoreland Water Quality Protection Act (Landscaping For Water Quality Workshop - 2026), Jay Aube

UNH Cooperative Extension

No abstract provided.

Layers Of Biodiversity: Linking Urban Garden Plants And Arthropods, Chenyang Su

Dartmouth College Ph.D Dissertations

Diverse arthropods play essential roles in urban agriculture, while urban agriculture provides food and habitat that support arthropod biodiversity in fragmented urban landscapes. In urban community gardens, a form of urban agriculture characterized by allotment-style gardens, arthropods interact with plants and green space across multiple spatial scales of management, from individual gardeners' plots to broad urban landscapes. Understanding how plant communities in urban community gardens and urban landscapes shape arthropod biodiversity and interactions across scales can inform both agricultural management and urban biodiversity conservation. In this thesis, I conducted a series of field studies on ecologically and economically important arthropods …

Rntuple For Atlas Analysis Workflow, Fatima Ariana Rodriguez

Graduate Research Theses & Dissertations

RNTuple is the new data storage format set to replace TTree at the start of the High-Luminosity LHC. An investigation was conducted to evaluate how analysis workflows for ATLAS researchers will change with RNTuple, using reading speed, writing speed, disk space, and memory consumption as metrics. In this study, all metrics were measured using converted RNTuple inputs from ATLAS Open Data, compared to their TTree equivalents. Additionally, RNTuples produced with the LZ4 compression algorithm were generated and compared with those produced using ZSTD. Finally, two new versions of the Analysis Grand Challenge (AGC) using ATLAS Open Data were completed for …

The Effects Of Problem-Based Learning On Mathematical Creativity And Self-Efficacy Of High School Students, Margaret Remus

Graduate Research Theses & Dissertations

Mathematical creativity is recognized as an important component of mathematics education; however, there is limited understanding of how instructional approaches can effectively support this skill among high school students, particularly through problem-based learning (PBL). This study examined the effects of problem-based learning on mathematical creativity among high school students.

This study employed a mixed-methods approach using an alternating treatment design with two groups of participants. Group 1 received the PBL intervention followed by a control condition, while Group 2 received the control condition followed by the PBL intervention. Quantitative data were collected through a mathematical creativity test measuring flexibility, fluency, …

Lucretius, Ovid, And Milton In Seventeenth-Century England: First Matter, Creation, And Food Of Angels, Conny M. Pfeifer

Graduate Research Theses & Dissertations

Paradise Lost is a complex poem that not only contains John Milton’s rendition of the Genesis creation narrative and the Fall of humankind but also provides a voice for his unique theology. This dissertation argues that Milton’s creative use of the three disparate concepts of consuming and digesting knowledge, chaos, and the night sky allows him to respond to Lucretian atomism, to address questions regarding the mortality of the soul, and to navigate the scientific discoveries of the seventeenth century, especially the astronomical discoveries of Galileo Galilei. An examination of digestion, chaos, and night helps shed light on Milton’s unique …

Ilr Masthead Volume 50

ILR Past Mastheads

No abstract provided.

Vape Counseling At Pediatric Practices: The Rethink Vape Toolkit, Paul T. Harrell, Ann L. Edwards, Natasha K. Sriraman, Rebecca J. Slimak, Anisha S. Vanka, Amy C. Paulson, Kelli J. England

Department of Pediatrics Faculty Publications

Introduction:

E-cigarettes (Vapes) represent the most common form of tobacco used by adolescents, with one out of every 29 (3.5%) middle school students and one in every 13 (7.8%) of high school students vaping daily. This project aimed to increase vape screening and prevention education in youth visits at pediatric practices, to increase provider comfort with the topic of vaping, and to evaluate this educational process.

Methods:

A provider training and resource modules (talking points, billing codes, and shareable parent/teen-tailored resources) were developed. Providers (N = 32) completed an anonymous pre/postsurvey regarding their knowledge, comfort levels, barriers, and practices related …

Bortezomib And Vorinostat In Combination With Mitoxantrone, Dexamethasone, And Pegasparaginase During Induction And Reinduction For Infants With Acute Lymphoblastic Leukaemia: A Multicentre Single-Arm Phase 1/2 Study, Tanja A. Gruber, Sima Jeha, Rebecca J. Deyell, Victor Lewis, Bill H. Chang, Eric J. Lowe, Jamie Frediani, Catherine Vezina, Bruno Michon, Michael Richards, Erin H. Breese, Thai-Hoa Tran, Norman Lacayo, Christine Bolen, Sunil Desai, Jennifer L. Pauley, Minxuan Huang, Emily Ashcraft, Cheng Cheng, Kirk R. Schultz, Linda Stork, Krysta Schlis, Van T. Huynh, Nathan Gossai, Yoav H. Messinger, Henrique Bittencourt, Terzah M. Horton, Uma Athale, Duncan Stearns, Deborah Schiff, Paul S. Gaynon

Department of Pediatrics Faculty Publications

Background: Acute lymphoblastic leukaemia in infants remains a therapeutic challenge. In preclinical studies we previously identified bortezomib and vorinostat as active agents against KMT2A rearranged (KMT2Ar) leukaemia. The aim of this study was to determine the tolerability of incorporating bortezomib and vorinostat into an acute lymphoblastic leukaemia-chemotherapy backbone for newly diagnosed infants with acute lymphoblastic leukaemia both with and without KMT2Ar.

Methods: In this single-arm phase 1/2 study conducted at 18 hospitals in the USA and Canada, we enrolled patients aged 1 year or younger at the time of diagnosis with newly diagnosed acute lymphoblastic leukaemia or undifferentiated leukaemia (with …

Incorporating New Guidelines Into School-Based Asthma Management, Jessica Michala Jindra, Angela Duff Hogan

Department of Pediatrics Faculty Publications

Purpose of the Review

The aim of this review is to identify barriers and provide solutions to the implementation of inhaled corticosteroid-formoterol as rescue therapy within schools.

Recent findings

GINA guidelines in 2019 and NAEPP in 2020 recommended inhaled corticosteroids combined with formoterol for a rescue inhaler over the traditional short-acting beta-agonist.

Summary

The findings discussed in this article describe the barriers to the implementation of inhaled corticosteroids combined with formoterol for a rescue inhaler in school systems. Traditional asthma action plans, school nursing and parental education, and differences in dosing are some barriers identified. This paper provides solutions for …

Empowering Caregivers, Protecting Patients: An Ambulatory Central Line Quality Improvement Initiative For Education And Follow-Up, Elizabeth Martinez, Belinda Bordeaux, Stephanie Langevin, Cristina Herrera, Mary Smith, Merissa Doyle, Barbara Stein, Kimberly Poshar, Marissa Dunlap, Allison Silva, Eric Werner

Department of Pediatrics Faculty Publications

Introduction: Preventing ambulatory central line-associated bloodstream infections (A-CLABSIs) is challenging due to inconsistent education, follow-up, and home care practices. Pediatric intestinal failure (IF) patients are particularly vulnerable. This institution aimed to decrease its IF A-CLABSI rate by 25% within 2 years through a standardized, step-by-step central line care education program.

Methods: Using the Toyota problem-solving method, the team reviewed data and performed a root cause analysis of the prioritized problem, implementing a 2-phase education program. Phase 1 delivered in-hospital education using videos, handouts, and hands-on teaching with skill demonstration. The existing pediatric central line skills class was expanded and offered …

Evaluating Planting Methods For Native Seed Production And Exploring Granivory In The Northern Great Plains, Allison Dollen

Electronic Theses and Dissertations

Temperate grasslands have faced immense losses due to land use change in the last 150 years and less than half of the overall grasslands that once covered North America remain today. A portion of historic and remaining U.S. grasslands are located within the northern Great Plains (NGP) region which is home to over 1,600 species of native plants and provides many ecosystem services and economic benefits. Initiatives to restore grasslands and their ecosystem services are currently underway, but barriers such as limited native seed supply and granivory hinder restoration efforts. My first chapter addresses knowledge gaps in planting methods for …

Impact Of Water Level Fluctuations On Fish Populations In Eastern South Dakota Rivers, Benjamin Schall

Electronic Theses and Dissertations

Riverine systems are highly dynamic, and changes in flow conditions can impact the population dynamics of fishes. Increased flows from historical averages in eastern South Dakota rivers have likely impacted fish populations. The goals of this study were to 1) better understand the changes in resource use by Blue Suckers Cycleptus elongatus through retrospective eye lens stable isotope analysis, 2) determine the effects of record flooding in the James River on complex woody habitat and Flathead Catfish Pylodictis olivaris population structure, and 3) assess the influence of river discharge and temperature on Channel Catfish Ictalurus punctatus and Flathead Catfish condition …

1941 Manchester University Air Squadron Group 15 April To 15 October 1941 Record Of Names In Book Of Remembrance, St Clement Danes, London 1993, Jenifer A. Harding

Documents

Record of those pilots who joined the Manchester University Air Squadron (MUAS) on April 15,1941 for a six-month short course for the RAF and are included in the Books of Remembrance held by the Church of St Clement Danes, The Strand, London, the central church of the Royal Air Force. Written in 1993 by Dennis Luke, MUAS 15 April – 15 October, 1941 and 5BFTS Course 5.

Molecular Diffusion In Chemically Amplified Resists For Euv Lithography, Eshan Dilina Thilakarathna

Electronic Theses & Dissertations (2024 - present)

Photolithography is a critical manufacturing step in high-volume manufacturing (HVM) of semiconductor devices, where a photoresist layer is used to transfer nanoscale patterns onto the underlying stack materials. As the microelectronics industry continues to move toward smaller node sizes, driven by Moore's Law. As a result, the tolerances for photoresist performance have become increasingly demanding, which necessitates simultaneous improvements in resolution, defectivity, and roughness. At advanced nodes, these performance limitations are governed by the fundamental stochastic nature of the photochemical processes occurring within the resist film itself, rather than the optical or tool-level constraints. Photon shot noise, the statistical distribution …

Lifting The Political Fog: People, Power, And Antislavery Politics In Upstate New York, 1848-1861, Nicholas Thony

Electronic Theses & Dissertations (2024 - present)

This work details the ascendance of the political antislavery movement in upstate New York, focusing on the roles a diverse array of actors played in constructing an unlikely Republican coalition of conservatives, reformers, black New Yorkers, nativists, prohibitionists, and abolitionists in the years preceding the Civil War. In weaving together the parallel and inextricable stories of powerful newspaperman Thurlow Weed, female reformers like Susan B. Anthony and Elizabeth Cady Stanton, and black communities across the state, I argue the success of the political antislavery movement resulted from their combined efforts. Thurlow Weed was one of the most important politicians of …

5bfts Grove At The Nma 03 Newsletter July 2001, Jenifer A. Harding

Documents

The UK National Memorial Arboretum (NMA) is at Alrewas, Staffordshire. The 5BFTS Association gave donations to the NMA which provided a Grove of five trees (five for number 5) comprising two English Birch trees and three American Birch trees and a Plaque. The Grove was dedicated in October 2002. Document 03 ‘5BFTS Association Newsletter July 2001’ informs members of the amount donated by the Association and individual members towards a 5BFTS memorial at the NMA

5bfts Grove At The Nma 05 Plans For Annual Reunion 2002, Jenifer A. Harding

Documents

The UK National Memorial Arboretum (NMA) is at Alrewas, Staffordshire. The 5BFTS Association gave donations to the NMA which provided a Grove of five trees (five for number 5) comprising two English Birch trees and three American Birch trees and a Plaque. The Grove was dedicated in October 2002. Document 05 ‘Plans for Annual Reunion 2002’ informs members about the proposed weekend in September 2002 which will include the Dedication of the 5BFTS Grove at the NMA.

5bfts Grove At The Nma 01 Planting For The Millennium, Jenifer A. Harding

Documents

The UK National Memorial Arboretum (NMA) is at Alrewas, Staffordshire. The 5BFTS Association gave donations to the NMA which provided a Grove of five trees (five for number 5) comprising two English Birch trees and three American Birch trees and a Plaque. The Grove was dedicated in October 2002. Document 01 ‘Planting for the Millennium’ explains how the NMA was conceived and the design for the RAF area.

Rebooting Administrative Enforcement For The Information Economy, Nina-Simone Edwards

Library Scholarship

This concept paper considers how to strengthen the enforcement of public mandates to deter harmful practices and business models. The paper offers principles for reinvigorated enforcement such as enhanced visibility, the increased use of design as a remedial lever, and personal responsibility for responsible individuals, not only the corporations that employ them.

To advance these principles, we call for new or amended laws that require companies to document how policy becomes code, grant agencies authority to order design changes to products and services, create pathways for charging responsible individuals, and cabin some forms of prosecutorial discretion. We would support these …

Legitimacy And Accountability In The Information-Era Administrative State, Nina-Simone Edwards

Library Scholarship

The current assault on administrative institutions and the rapid influx of automated “solutions” have exacerbated the problems of a system that was already buckling under the strains of functional opacity, technical opacity, unequal access and influence, process proliferation and paralysis, and inaction. An overarching reason for the legitimacy and accountability challenges confronting the administrative state is a paradigm for administrative legitimacy and accountability that is court-centered and no longer fit for purpose.

In this concept paper, we describe two core requirements of legitimacy and accountability–which, as we will explain, are interdependent concepts–and then articulate three component requirements–transparency and demystification, care …

Quantum Mechanics As A Framework For Data Assimilation And Its Application To Atmospheric Parameterization, David Freeman

Dartmouth College Ph.D Dissertations

Quantum mechanics, as a mathematical system, can be understood as a generalization of classical probability theory. Quantum Mechanical Data Assimilation (QMDA) is a method in which classical dynamical systems are embedded into a quantum mechanical setting, with an associated data assimilation scheme leveraging the operator algebraic setting. In this dissertation, the algebraic structure underlying the operator theoretic formulation of QMDA is discussed. A procedure for closure of dynamical systems based on QMDA, known as Quantum Mechanical Closure (QMCl), is then constructed, and the procedures for constructing the quantum embeddings and implementing QMCl in practice are laid out and implemented for …

Exploring The Academic Trajectories Of Transfer Students Enrolled In An Introduction To Proof Course And Their Self-Efficacy For Proving, Sundas Hussain

Mathematics Dissertations

Transfer students entering proof-based mathematics courses face a double transition: they are adjusting to a new institution while simultaneously learning to construct mathematical proofs. Although transfer students have been widely studied in higher education and self-efficacy for proving has received increasing attention in mathematics education, little research has examined the intersection of these two areas. The purpose of this study was to better understand how transfer students’ academic trajectories shape their self-efficacy for proving. This multiple case study examined twelve transfer students enrolled in an Introduction to Proofs (ITP) course, using Bandura's (1997) four sources of self-efficacy as the …

Targeting Nuclear Receptors In Muscular Dystrophies And Regenerative Myogenesis, Eira Mann, Hoang Vu, Vihang A Narkar, Yu Liu

The Brown Foundation: Institute of Molecular Medicine

Skeletal muscle is a highly plastic tissue with a robust capacity for regeneration, largely driven by resident satellite cells. Muscular dystrophies comprise a heterogeneous group of inherited disorders characterized by progressive muscle degeneration, chronic inflammation, and impaired regenerative capacity. Despite well-defined genetic etiologies, effective disease-modifying therapies for these disorders, as well as many acquired myopathies, remain limited. Emerging evidence identifies nuclear receptors (NRs) as key regulators of skeletal muscle homeostasis, integrating hormonal, metabolic, and environmental signals to control transcriptional programs governing mitochondrial function, metabolism, inflammation, and myogenesis. In this review, we summarize the diverse roles and mechanisms of action of …

Immune Checkpoint Inhibitor-Induced Cardiotoxicity: From Immune Mechanisms To Clinical Surveillance And Targeted Therapies, Nathan K Chen, Kathryn D Hok, Narsi Chokshi, Anthony Shadid, Haydn E Rich, Lavanya Gunamalai, Marie-Francoise Doursout, Nirmal K Banda, Pooja Shivshankar

The Brown Foundation: Institute of Molecular Medicine

Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape across a broad range of malignancies by restoring antitumor immunity through blockade of key inhibitory immune pathways, including programmed death receptor-1 (PD-1), programmed death ligand-1 (PD-L1), and cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4). Yet the same widespread immune activation that drives their therapeutic benefit renders patients susceptible to immune-related adverse events (irAEs). Among these cardiovascular toxicities have emerged as a particularly critical concern, drawing growing attention within the evolving field of cardio-oncology. ICI-associated cardiotoxicity encompasses a broad clinical spectrum, ranging from myocarditis and pericarditis to arrhythmias, heart failure, and vascular complications. Of these, …

Course Portfolio For A New Course On Data Analysis And Visualization In Animal Research, Jessie C. Morrill

UNL Faculty Course Portfolios

This course portfolio describes the design and development of a new course focused on data analysis and visualization in animal research at the University of Nebraska – Lincoln. The course was developed to meet the needs of students enrolled in Master of Science and Doctor of Philosophy graduate programs in the Department of Animal Science as well as those in the Master of Applied Science in Beef Cattle Production program. The new course was taught on an exploratory basis in Fall 2024 and Fall 2025; the perspectives of both students and the instructor are contained within this portfolio. The reflections …

Assessing Global Citizenship Pathways In A Communication, Advocacy, And Global Citizenship Classroom In The Midwest, Satveer Kaur-Gill

UNL Faculty Course Portfolios

To assess instruction in an undergraduate communication course titled Communication, Advocacy, and Global Citizenship, this qualitative inquiry examined how undergraduate students at a Midwest university engaged with global citizenship as a communicative process by conducting a content analysis of student assignments, guided by three key research questions formulated from four course objectives. The assessment found that place-based learning on global issues enhanced students' understanding of the meaning of global citizenship in a globalized world. Based on a qualitative evaluation of their key assignments, students successfully articulated threads and connections between local community concerns and issues as globally situated communicative phenomena. …

First Portfolio – Mngt 475: Business Strategies, Lisa Tschauner

UNL Faculty Course Portfolios

MNGT 475: Business Strategies serves as the undergraduate strategic management capstone course in the University of Nebraska–Lincoln College of Business. The course integrates knowledge from accounting, finance, economics, marketing, management, supply chain management, analytics, and entrepreneurship while providing students with opportunities to apply strategic frameworks to authentic business challenges. This portfolio documents the design, implementation, assessment, and continuous improvement of the course, with particular attention given to experiential learning and the comparison of two instructional models: a traditional case-study project and a real-world industry-partner consulting project. Drawing upon Kolb’s Experiential Learning Theory, self-reflection, self-efficacy, and teamwork constructs, the portfolio examines …

Confidentiality And Legal Aid Data, Keith Porcaro

Duke Center on Law & Technology

This report assesses the reidentification risk of civil legal aid reporting data in Washington State, and suggests strategies for mitigating that risk.

Learning About Land Through Indigenous Storywork, Critical Information Literacy, And Archival Research At The Northern Shores Storywork Project Site, Kel Sassi

Journal Articles

This article takes a critical approach to an Information Literacy and Leadership Institute (Institute) for Upper Peninsula K-12 educators with the goal of coming to terms with the dispossession of Indigenous peoples in the region. Participants learned about critical information literacy in relation to archival materials about settler colonization and resource extraction and created curriculum materials for their classrooms. Facilitators designed institute activities with Archibald’s Indigenous Storywork principles in mind and analyzed the outcomes through this framework. The focus on land was reflected in teacher materials, but could be integrated more deeply in future institutes.