Digital Commons Network^™

Solid-State Forms And Compositions Of Bexicaserin, Prashanth Venukathala, Venukathala Prashanth

Defensive Publications Series

The present invention relates to the field of pharmaceutical sciences and medicinal chemistry. More particularly, the invention relates to novel crystalline forms, amorphous forms, co-crystals, solid dispersions, pharmaceutical compositions, processes for preparing the same, and methods of use thereof comprising Bexicaserin or a pharmaceutically acceptable salt thereof.

Autonomous In-Loop Sealing Of Microdefects In Cryogenic Systems Of Particle Accelerators, Fusion Reactors And Space Technology Using Circulating Nanocapsulated Agents, Volodymyr Kotegov

Defensive Publications Series

Operation of large-scale cryogenic installations—particle accelerators, fusion reactors, space propulsion stages and quantum systems—demands continuous maintenance of leak-tightness in coolant and liquefied-gas circulation loops. Conventional methods for locating and repairing microleaks through intergranular pores of structural materials and microcracks in welded joints require complete shutdown of equipment, prolonged thermal recovery of isolated sectors and external mechanical intervention.

This publication presents a method of autonomous in-loop sealing in which the working cryogenic fluid itself serves as the carrier medium for functional nanocapsules. The method relies on thermodynamic, barometric, mechanical and electro-inductive triggers. When the nanostructured suspension passes through a microdefect into …

Novel Process For The Preparation Of Lazertinib Mesylate, Msn Laboratories Private Limited, R&D Center, Hyderabad, India, Srinivasan Thirumalai Rajan, Sagyam Rajeshwar Reddy, Mohammad Rafee Shaik, Buvanagiri Ajay Kumar

Defensive Publications Series

Novel Process for the preparation of Lazertinib Mesylate The present invention relates to a novel process for the preparation of N-[5-[[4-[4-[(dimethylamino) methyl]-3-phenylpyrazol-1-yl]pyrimidin-2-yl]amino]-4-methoxy-2- morpholin-4-yl phenyl]acrylamide or a salt thereof, which is referred to as Lazertinib, represented by the following structural formulae

Formula-I

Method And System For Dynamic Trust Orchestration In Payment Networks, Pranjal Gautam, Sakshi Goyal, Divya Jain

Defensive Publications Series

A method (500) for dynamic trust orchestration in payment networks is provided. The method (500) includes receiving (505) data pertaining to a payment event associated with a payment transaction occurring within a payment network, identifying (510) a plurality of entities associated with the payment event from the received data. The method (500) further includes configuring (515) a relationship graph at a graph database with nodes representing the plurality of entities and edges representing relationships among the plurality of entities. The method (500) further includes extracting (520), transaction features, historical features, lifecycle features, and graph-context features from the relationship graph. The …

Automated Analysis Of Advertising Coverage Gaps And Taxonomic Expansion Opportunities, N/A

Defensive Publications Series

An inefficiency in digital advertising may arise when campaigns do not cover a range of products on an advertiser's digital properties (e.g., a website or mobile application), a discrepancy that can be challenging to identify manually. Systems and methods are described that may act as an orchestration engine to programmatically address such discrepancies. A system can programmatically harvest inventory from an advertiser's digital property, retrieve active campaign data from an advertising account, and map both data sets to a common taxonomy to identify potential coverage gaps. The system may also enrich these findings with external market data and suggest semantically …

Dynamic Adaptation Of In-Memory Data Structures For Session-Specific Workloads, Abirami Sukumaran

Defensive Publications Series

Systems and methods are described for a polymorphic in-memory data store that can dynamically adapt its physical structure on a per-session basis. Some applications may experience performance bottlenecks from rigid, static in-memory data structures that may not be well-suited for certain dynamic workloads. The described technology can analyze real-time indicators, such as incoming data patterns and executed query types, to help determine a suitable memory layout. An adaptive engine can then transition the physical representation of the data between different formats, such as key-value, columnar, document, or vector-indexed structures. This approach may allow the in-memory data representation to align with …

Speculative Resource Pre-Warming Based On Partial Agent Output, Sarita A. Joshi, Lavi Nigam

Defensive Publications Series

In multi-agent systems, such as those organized as directed acyclic graphs, cold-start initialization latency at transitions between agent nodes can create performance bottlenecks. This delay can occur when a system waits for an upstream agent to complete its task before preparing resources for the subsequent downstream agent. The described systems and techniques can address this by implementing speculative resource pre-warming. A system can monitor the partial output of an active upstream agent to extract a routing fingerprint and predict the likely next agent in the workflow. Based on this prediction, computational resources for the downstream agent, such as models and …

Mitigating High Central Processing Unit (Cpu)-Induced Link Aggregation Control Protocol (Lacp) Flapping In Large-Scale Bundles, Anthoni Rajanikanth Jasti

Defensive Publications Series

Large-scale data center and enterprise networks frequently employ Link Aggregation Control Protocol (LACP) to aggregate multiple physical interfaces for redundancy and bandwidth. However, high central processing unit (CPU) utilization can disrupt LACP operations, causing interface flapping and network instability, especially when fast LACP timers and many virtual local area networks (VLANs) are configured. A mitigation technique is proposed herein that uses the LACP Out-of-Sync bit to coordinate interface unbundling during high-CPU events, thereby reducing repeated timer-driven flapping and supporting orderly recovery.

Architectural And Mathematical Foundations Of Transform Coding In Image Compression: From Multiresolution Wavelet Pyramids To Hardware-Accelerated Discrete Wavelet Transform Silicon Engines, Gopi K. Tummala

Defensive Publications Series

As distributed compute platforms and high-resolution imaging pipelines scale, uncompressed raw visual data presents a severe transmission bandwidth and memory storage wall. A 24-bit 1024 × 1024 uncompressed frame consumes 3.0 MB of storage, requiring over 7 minutes to transmit across legacy 64 Kbit/s ISDN channels, whereas a 10 : 1 compression reduces this footprint to 300 KB and sub-6-second latencies. This research paper presents a comprehensive mathematical, algorithmic, and microarchitectural evaluation of foundational transform coding paradigms—spanning Discrete Cosine Transform (DCT), Karhunen-Lo`eve Transform (KLT), Fractal Iterated Function Systems (IFS), Spline Regularization, and Multiresolution Discrete Wavelet Transforms (DWT). We formulate the …

Verified-Email Household Principals With Hash-Only Calendar-Feed Capabilities And Atomic Rotation-Based Revocation, Joel Kandy

Defensive Publications Series

A multi-tenant activity-registration platform resolves a household (“family”) account's data by

verified email address alone — with no claim or migration step — and derives from that account a

single aggregated calendar-feed capability URL whose bearer token is stored server-side only as a

domain-prefixed cryptographic hash. Revocation of the feed URL is never a separate operation: it

occurs atomically as a side effect of either (a) re-copying the feed link, which always re-mints the

token, or (b) any change to the account's verified email identity, which nulls the stored hash. The

feed endpoint is served with Cache-Control: private so that …

Time-Division Multiplexing And Adaptive Connection Adjustment In Pipeline Arrays, Jinhui Wu

Defensive Publications Series

This paper describes a time-division multiplexing implementation of Pipeline Arrays. Through TDM and
BRAM-based state management, a limited number of physical Pipelines support a larger number of
Pipeline instances. Each Pipeline instance maintains independent energy state management with automatic
deactivation upon energy depletion. This paper also describes state replication and migration methods,
adaptive adjustment of connection relationships, sparse connection storage and query methods, energy
state propagation and influence calculation, as well as statistical metric collection and event detection. The
above solutions are described in a parametric manner, and relevant parameters can be adjusted according
to actual requirements.

Numerical Validation Of An Aperiodic Bi-Ionic Magnetic Nozzle Architecture For High-Field (48.38 T) Continuous Electromagnetic Acceleration., Daniel Schramm

Defensive Publications Series

This disclosure details the multi-physics finite element verification and structural co-optimization of a continuous-operation, meter-scale electromagnetic propulsion architecture. The design utilizes a bi-ionic, aperiodic golden-ratio magnetic nozzle configuration. Computational evaluation confirms structural, thermal, and electrical viability under a continuous 48.38 Tesla field at a 1 Megawatt load.

Key closed-loop validation metrics include:

• Structural Containment: Implementation of a 32% CuNb/high-strength metal interleaving fraction successfully attenuates peak local magnetic stresses (1.630 GPa), yielding a secure 1.40x safety margin against an 80.0 MPa epoxy delamination threshold.

• Electrical Viability: The co-optimized winding pack sustains an engineering current density of 227.5 A/mm², maintaining the critical …

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Ccwe‑Ω4.0 — Unified Atmospheric‑Hydrodynamic‑Plasma Clean‑Water Engine A Builder‑Ready, Multi‑Physics Pfas/Microplastic Mineralization Reactor For Global Deployment, Michael Victor Caldwell Mr.

Defensive Publications Series

The CCWE‑Ω4.0 is a fully integrated, open‑hardware clean‑water engine designed to permanently destroy PFAS, microplastics, pathogens, hydrocarbons, and recalcitrant contaminants using a unified multi‑physics architecture. Unlike conventional filtration systems that trap contaminants on media, CCWE‑Ω4.0 performs true molecular mineralization, eliminating toxic waste streams entirely.

CCWE‑Ω4.0 integrates:

• Atmospheric water harvesting (GCI #272 Hyper‑Arid MOF Engine)

• Hydrodynamic cavitation (VMR Titan‑2.0)

• Acoustic vortex concentration (Vortex Sentinel AV‑1)

• Cold‑plasma PFAS destruction (Sentinel‑AV‑1‑2.0)

• Gyroid thermal buffering (Forgecell Prime‑2.0)

• Gyroid cooling & resilience (UGCRM‑1.0)

• Multi‑modal resonance mapping (MMRA‑2.0)

• Cognitive multi‑physics stabilization (CMRS‑1)

• Thermoacoustic gradient amplification (CRFG‑1R‑2.0)

• Atmospheric resonance alignment (ARPN‑2.0)

• Hydrology mapping (GRHN‑2.0)

• Off‑grid energy harvesting …

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Multi-Probe Dehp Validation Protocols For Jwst, Euclid, And Roman Space Telescope Telemetry Data, Christopher L. Eckes

Defensive Publications Series

Modern cosmological observations are encountering acute foundational tensions within the standard ΛCDM framework. These include the 5σ Hubble Tension, anomalously mature galaxy populations at high redshifts (z > 10) revealed by the James Webb Space Telescope (JWST), and large-scale cosmic anisotropy dipoles detected in radio and infrared surveys. This white paper presents a formal empirical framework to evaluate the Dimensionally Extended Holographic Projection (DEHP) model against these anomalies. By treating space-time as an emergent bulk generated by a two-dimensional boundary information layer, DEHP treats cosmic expansion as a manifestation of viscoelastic substrate mechanics rather than an intrinsic vacuum metric expansion. We …

Token Prediction Using Grammar Estimation, Shivam Mohan

Defensive Publications Series

A system for token prediction using grammar estimation includes a sequence intake component configured to receive a token sequence and organize the token sequence into ordered progression units retaining positional and temporal structure. A context conditioning component associates the token sequence with contextual dimensions comprising user-specific interaction patterns, session-local behavior, and environmental state. A grammar estimation component maintains a state-transition graph comprising states representing progression conditions inferred from observed token behavior and transitions accumulating evidence of how token sequences evolve. A state merge component computes a merge score for state pairs based on token co-occurrence frequency, similarity of transition neighborhoods, …

Adaptive Real-Time Ml Monitoring, Drift Detection, Cross-Environment Psi, And Hyperscale Authorization For Multi-Rail Payment Fraud Prevention, Durga S. Kala, Jun Xu, Ankana Sonowal, Yidong Fu

Defensive Publications Series

A computer-implemented system for monitoring machine learning model input feature health in a payment transaction authorization network. The system includes a distributed audit log extraction pipeline configured to ingest ML model scoring event records, filter records by model identifier and issuer processor affiliate identifier, and flatten nested JSON request and response structures into columnar format. The system includes a transaction-type partitioning module configured to split the flattened dataset into per-transaction-type subsets corresponding to different authorization pathways. The system includes a numerical feature statistics engine configured to compute distributional statistics for numerical scoring features. The system includes a population stability index …

Adaptive Media Interruption Placement Using Causal Analysis Of Audience Engagement, Joanna Piega, David Lepkowski, Szymon Socha

Defensive Publications Series

A challenge in the field of digital media distribution relates to static interruption placements, such as advertisements, which may be determined without considering evolving audience engagement data. This approach can result in interruptions during periods of low viewer interest, potentially increasing session abandonment. Systems and methods are described that can address this by utilizing a quasi-experimental statistical framework to analyze audience engagement data. The framework may compare viewer abandonment rates between sessions where an interruption was presented and sessions where an interruption was not presented for the same temporal location. This comparison can yield a causal abandonment penalty metric for …

System For Automated Cross-Feed Auditing Of E-Commerce Product Data, N/A

Defensive Publications Series

In multi-channel e-commerce, merchants may utilize separate product data feeds, for instance, for online and local inventory, which can lead to data conflicts and inconsistencies that may not be detected by single-feed validation checks. A system for automated, cross-feed auditing can address these potential issues. The system can integrate and cross-reference data from multiple sources, including online, local, and historical data repositories, to create a more comprehensive view of product data. It may use analytical modules to identify price or availability discrepancies between feeds, diagnose reasons for suppressed promotional badging based on time-series rules, and suggest missing product attributes based …

Autonomous Orchestration Of Trend-Driven Advertising Using Semantic Product Matching, Jasbeer Arora, Anurag Tripathi, Gurvinder Singh

Defensive Publications Series

Digital advertising may be challenged by latency in manual workflows and a semantic gap between fast-moving cultural trends and structured product data, potentially resulting in missed commercial opportunities. A described system can address these challenges using an automated, multi-agent orchestration workflow. For example, a surveillance agent can identify breakout trends from various data streams, such as social media feeds or search queries. These trends may then be semantically expanded using a large language model. The expanded description can be converted into a vector embedding to perform a similarity search against a vector database of a product catalog, which may identify …

A Review On Traditional And Modern Aspects Of Vitex Negundo L.: Ethnomedicine, Phytochemistry, And Pharmacology, Tathagata Khanra, Suvasish Mitra, Subham Saha, Maitryee Mondal, Subhash C. Mandal

International Journal of Traditional Knowledge

Vitex negundo L., or five-leaved chaste tree, is a medicinally significant plant widely distributed in Asia and other tropical regions, frequently utilized in traditional healing systems for a spectrum of ailments. This comprehensive review consolidates current knowledge on the botany, traditional uses, phytochemical constituents, and pharmacological potentials of Vitex negundo L. The plant is rich in diverse bioactive compounds such as flavonoids, alkaloids, glycosides, and terpenoids, which are primarily responsible for its multidimensional therapeutic actions. Scientific investigations have substantiated its role in exerting anti-inflammatory, analgesic, antimicrobial, antioxidant, hepatoprotective, nephroprotective, insecticidal, anticancer, and antidiabetic effects, among others. Research reveals promising enzyme-inhibitory, …

Siddha Formulations: A Traditional Reservoir Of Valuable Medicines For The Contemporary World, Agnes Preethy

International Journal of Traditional Knowledge

Traditional Medicine had been practised for many centuries in different parts of the world. However, the deep insights drawn from the traditional knowledge have remained highly localized as it had been privy only to the generations of traditional medicine practitioners. This, combined with lack of scientific evidence of their therapeutic action, had limited access, acceptance and awareness of these preparations to the larger segment of the community. The emergence of new lifestyle disorders and drug-resistant diseases in recent years has fuelled the search for alternate treatment strategies and has revived interest in traditional medicines. Concerted efforts to decipher the molecular …

Ayurvedic Herbs In The Management Of Benign Prostatic Hyperplasia: A Comprehensive Narrative Review, Latha Damle, Chandrasekhar C

International Journal of Traditional Knowledge

Benign Prostatic Hyperplasia (BPH) is a common, non-cancerous enlargement of the prostate gland, primarily affecting older men. It frequently leads to lower urinary tract symptoms (LUTS) such as increased urinary frequency, urgency, nocturia, and weak urine flow, which can significantly impair quality of life. Standard treatments for BPH include alpha-blockers, 5-alpha reductase inhibitors, and surgical interventions. However, limitations in efficacy and potential adverse effects have driven interest in complementary and traditional therapies, including Ayurveda. In Ayurvedic medicine, BPH is described as Mutraghata and Vatashthila, conditions attributed to an imbalance of Vata and Kapha doshas that disrupt normal prostate and …

Unveiling The Night-Flowering Jasmine: A Comprehensive Review Of Nyctanthes Arbor-Tristis’ (Oleaceae) Phytochemistry, Ethnomedicine, And Therapeutic Potential, Subham Saha, Soumya Mitra, Tathagata Khanra, Saban Karmakar, Tamalica Hore, Subhash C. Mandal

International Journal of Traditional Knowledge

Nyctanthes arbor-tristis (NAT), typically known as Night-flowering Jasmine or Harsingar or Parijat, is one of the prominent medicinal plants indigenous to the Indian subcontinent. Its application dates back to ancient times, with substantial documentation in former religious texts. Native communities have traditionally used this for various human ailments and as an ornamental plant. Leaves, flowers, seeds and stems of this plant are rich in various primary and secondary metabolites, providing a wide range of pharmacological effects. The most abundantly found phytoconstituents belong to iridoid glycosides, such as arbortristosides. Comprehensive research has investigated its potential in anticancer, antiviral, and anti-inflammatory activities, …

Addressing Sustainability Challenges: Perspectives From Bhagavad Gītā, B Mahadevan, Dhrithi Mahadevan

International Journal of Traditional Knowledge

The industrialization-driven growth has ushered in economic progress over the past few centuries. However, it has also raised serious concerns about the sustainability of life on this planet. Despite considerable attempts to address sustainability issues using newer frameworks and efforts by corporates as well as governmental, and non-governmental institutions, we have remained ineffective in implementing sustainable solutions. The “last mile” to successfully implementing sustainable solutions is the individual. This calls for addressing individual values and aligning them to sustainability. This paper presents a fresh perspective on the problem by drawing some insights from the Bhagavad Gītā. We introduce the basic …

A Treasure House Called Traditional Knowledge, Sudha Seshayyan

International Journal of Traditional Knowledge

Centuries of observation, experimentation, and cultural continuity have formed the basis of traditional knowledge, which is a huge and complex repository of scientific information. Engineering, hydrology, fluid dynamics, medicine and cosmology are just a few of the many domains in which ancient Indian wisdom demonstrates an astonishing depth of factual understanding that is ingrained in daily activities, architectural principles, and literature. From Avvaiyar’s verses of wisdom to the magnificent temples whose architecture continues to amaze humanity and the structural brilliance of the Kallanai dam constructed in the second century CE and still serving the local population, all serve as testimony …

Agrarian Festivals Of India- Embedded Traditional Knowledge About Environment And Ecology Preserved Across Millennia, Lopamudra Maitra

International Journal of Traditional Knowledge

With a prominent agrarian economy, it is important to note the many agrarian festivals from across the nation. These festivals also help to highlight many rites, rituals and folklore, which forms the basic ethos of the celebrations and within the many layers of these are embedded knowledge about environment and ecology, which has been passed down through thousands of centuries. These have also been variously corroborated through archaeological, historical and epigraphical records of ancient India. This paper is an attempt to highlight this historicity of the agrarian festivals of India, which also corresponds to the mainstream festivals from across India, …

Gaining From Captured Indian Traditional Knowledge Systems: Paths Taken And Way Forward, Ramasami T

International Journal of Traditional Knowledge

India’s scientific heritage is deeply reflected in Ayurveda, a tradition of integrative medicine documented for over two millennia. P.C. Ray, the father of modern chemistry in India, highlighted the depth of ancient chemical knowledge and early use of mercury compounds, while M.S. Valiathan later revived and analyzed the classical texts of Charaka, Sushruta, and Vagbhata to bridge Ayurveda with modern science. Building on this foundation, the Government of India launched initiatives linking Ayurveda with genomics, personalized medicine, and rasayana therapies, yielding promising insights such as the genetic basis of prakriti classifications and protective effects of Amalaki Rasayana. Efforts like the …

The Influence Of Managerial Attitudes And Dynamic Capabilities On E-Marketing Adoption Among Small And Medium Tourism Enterprises, Hilal Maabad Ame, Omari Khalifa Mbura, Amani Gration Tegambwage

Arab Economic and Business Journal

This study examines how managerial attitudes and dynamic capabilities shape e-marketing adoption among Small and Medium Tourism Enterprises (SMTEs) in Zanzibar, using PLS-SEM on survey data from 216 SMTEs in the Urban-West and South Regions. Drawing on the Decomposed Theory of Planned Behaviour and Dynamic Capabilities Theory, the study finds that perceived ease of use and perceived security significantly increase adoption, while perceived usefulness and compatibility significantly decrease it suggesting that recognising a technology's value is insufficient without the operational capacity to act on it. Supporting this, dynamic capabilities significantly strengthen the usefulness–adoption and compatibility–adoption relationships, but show no moderating …

Fabrication Of Objectives For Imaging Ultracold Lithium, Danelle Akanova

Dartmouth College Master’s Theses

This thesis develops a documented, reproducible procedure for building diffraction-limited microscope objectives entirely from catalog singlets, for imaging ultracold 6Li atoms in a ring-trap experiment. The objectives must resolve micron-scale features through a 5 mm fused-silica vacuum window, operate at multiple wavelengths, fit inside a 48 mm magnet bore, and contain no conductive or magnetic material, because the surrounding coils switch 0.1 T fields on microsecond timescales. Commercial long-working-distance objectives are universally housed in metal, which the eddy-current constraint rules out, and custom fabrication of a suitable non-conductive matched pair is estimated at nearly $200k.

The procedure is developed and …

Michael Blauser V. Caleb Quimby

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