Digital Commons Network^™

Evolving Trends In Organ Donation, Recovery, And Utilization In The United States: A Decade Of Change And The Impact Of Covid-19, Nirmay H. Rokad, Ohm Tripathi

UROP Posters

Evolving Trends in Organ Donation, Recovery, and Utilization in the United States: A Decade of Change and the Impact of COVID-19 Background: Over the past decade, organ donation and transplantation in the U.S. have undergone substantial changes, influenced by evolving donor practices and the COVID-19 pandemic. We examined national trends in donor types, organ recovery, utilization, and discard rates between 2012 and 2023. Methods: We analyzed SRTR/OPTN registry from 2012–2023, including total deaths, DBD (donation after brain death); DCD( donation after circulatory death); NRP (normothermic regional perfusion), organ authorization, recovery, transplantation, and discard rates. Pre-COVID (2016–2019) was compared with post-COVID …

Mapping Leo Satellite Internet Performance Using Mobile Starlink Deployment, Annika Govil, Jacob Gray

UROP Posters

High-speed, low-latency internet connectivity on the move is a critical challenge for applications in connected vehicles, disaster response, and remote education. While terrestrial networks such as 4G or 5G are widespread, they lack coverage in remote or rural geographic areas.

Low Earth Orbit (LEO) satellite constellations, such as SpaceX's Starlink, promise global high-bandwidth, low-latency internet. However, their performance is well-documented in stationary scenarios, while data for *mobile* applications is scarce. This project explores the feasibility and real-world performance of LEO satellite internet while in motion.

Current research documents the performance of LEO satellite constellations in stationary settings. However, data concerning …

Interpreting “Vampire” Burials In Medieval Eastern Europe, Arleen Chau

UROP Posters

Since the early twentieth century, various atypical or deviant graves have been excavated across Eastern Europe, particularly in Poland. These discoveries have prompted much speculation, as the individuals were interred with items such as sickles placed over their necks or abdomens, along with other mortuary artifacts not considered normative compared to those found in typical community burials. Such practices suggest that these individuals were regarded as deviant or pariahs within their social contexts. Consequently, many have been quick to label these as “vampire burials,” interpreting them as measures intended to keep the dead from rising. However, this definition is problematic, …

Neuron-Enriched Extracellular Vesicle Micrornas Reflect Hormonal Suppression Associated With Oral Contraceptive Use In Young Women, Amulya Chowdhory, Rebekah Frye, Roxann Roberson-Nay

UROP Posters

Hormonal contraceptives alter hypothalamic–pituitary–ovarian (HPO) feedback, but their impact on brain-associated molecular communication remains poorly understood. Neuron- enriched extracellular vesicle (nEV) microRNAs (miRNAs), isolated from plasma, provide a minimally invasive window into brain molecular activity. This pilot study examined nEV miRNA expression in young women (ages 18–22) who were either naturally cycling or using a combined monophasic oral contraceptive (OC) pill. To identify hormonally responsive miRNAs, we calculated effect sizes (Cohen’s d) between the two groups and selected those showing large between-group differences (|d| ≥ 0.8). These miRNAs were entered into a principal component analysis (PCA) to reduce dimensionality, and …

Did Our Prehistoric Ancestors Engage In Mortuary Practices?, Regina E. Mcrae

UROP Posters

Abstract

Mortuary practice is defined as how humans dispose of and treat their dead. We are familiar with elaborate burials such as the entombment of pharaohs in the pyramids at Giza; Necropolises of the Valley of the Kings and Queens; the Mausoleum at Halicarnassus; the Taj Mahal in India; Viking funeral pyres on boats; and the modern jazz funerals of New Orleans. Caring for our dead is believed to be a modern concept, practiced by Homo Sapiens. However, archeological excavations and scientific analyses show burial practices predate modern man, practiced by our ancient ancestors such as Neanderthal, Homo Naledi, and …

Using Nature-Inspired Sustainable Design Via Biomimicry Of The Peregrine Falcon To Improve The Development Of Japan’S F-X Fighter Jet, Tvisha Datta

UROP Posters

Modern fighter jets face a persistent challenge when it comes to improving aerodynamic efficiency without having to sacrifice high-speed performance or long-term sustainability. These aircraft rely heavily on high thrust and agility, and in doing so, they consume substantial amounts of fuel due to aerodynamic drag and limited energy efficiency. As a result of these constraints, advanced military defense development projects, such as Japan’s Mitsubishi F-X fighter jet program, have been delayed. This highlights the need for more sustainable solutions. Biologically inspired design, or biomimicry, has emerged as a potential and promising alternative. The peregrine falcon, notably the fastest bird …

Agrivoltaics Swot Analysis For Implementation In The United States, Vani Ramesh

UROP Posters

Agrivoltaics is the implementation of solar installations alongside agricultural land in order to improve the efficiency of land usage in both industries. Research in European and Asian countries developing agriculture and solar developments in tandem has indicated that implementation in the United States, including Virginia, is feasible and beneficial. The US has the highest energy use per capita in the world, with the increase of various technologies has resulted in land developments using higher energy levels than previously. While Virginia’s energy demand has increased with the addition of data centers. Increased energy demand and food security requirements have unearthed policy/political …

Neanderthals And Their Exhibitions Of Fine Art: Unpacking Neanderthal Art On The European Continent, Jacob T. Simpson

UROP Posters

This research project aims to bridge the gap between anatomically modern humans and our closest genetic relative, Neanderthals. By analyzing research literature on artistically symbolic artifacts potentially created by these ancient humans (focusing on populations in Europe) I hope to offer a superior speculation of Neanderthal intellect. Neanderthals potential capability to create artistic objects could transform our understanding of them and their cognitive abilities, and raise philosophical questions on what it means to be human.

Llm-Driven Weekly Newsletter To Assess Open Source Software Project Github Health, Christian Novalski, Christopher Chavez, Ghalian Fayyadh, Kostadin Damevski

UROP Posters

Open Source Software (OSS) projects increasingly depend on a diverse set of contributors, including episodic participants who contribute intermittently. Episodic contributors represent a large portion of OSS communities, yet projects often struggle to retain them, leading to decreased project health and continuity. While dashboards and real-time communication tools support continuously active contributors, they often fail to serve the unique needs of episodic participants, who may struggle to remain informed and re-engage with project activity after periods of absence. In this study, we examine the effect of a weekly, email-based newsletter intervention designed to improve awareness and engagement among episodic OSS …

The Effects Of Coping Motives On Alcohol Use Consequences, Madisyn E. Feliciano, Samantha Pelfrey

UROP Posters

The purpose of this study was to examine the difference in alcohol use consequences between those who drink to cope with anxiety or depression symptoms and those who do not. Our research aimed to expand on earlier studies by placing emphasis on how coping with anxiety and depression influences alcohol consequences using constructs aligned with DSM-V symptom criteria. Research has consistently shown that those who drink to regulate distressing emotions experience more harmful consequences, making this an imperative area for prevention efforts. It was hypothesized that coping motivated drinking would be associated with an increased amount of alcohol related consequences. …

The U.S. Campaign Gacha System And Youth Underrepresentation, Rebecca Burrows, Eleanor Harris

UROP Posters

This research investigates why young people remain underrepresented in elected U.S. offices and why youth voter turnout has historically remained low. Motivated by persistent shortcomings in U.S. youth turnout, the dominance of older elected officials, and recent high-profile victories by young mayoral candidates, this study asks whether young candidates (< 40) increase youth voter turnout in U.S. elections—and, if so, whether structural factors prevent these candidates from winning. Existing literature on descriptive representation and electoral inequality suggests that young candidates may energize youth voters yet face systemic disadvantages that hinder their success. This research contributes to the literature by exploring how the U.S. campaign finance system shapes young candidates’ electoral viability. Using a qualitative comparative case study design, we analyzed four large U.S. mayoral elections: two with victorious young candidates (Boston 2021; New York City 2025) and two where no candidate under 40 appeared on recent ballots (Los Angeles and Columbus). For each city, candidate eligibility rules, ballot requirements, party bylaws, primary election methods, and campaign finance laws were examined using publicly available legal and institutional documents. This approach allowed us to identify structural barriers while remaining open to unanticipated patterns across cases. Our findings reveal no explicit legal or party rules that impede young candidates. Instead, obstacles lie implicitly in the U.S. campaign finance system’s lack of limits on contributions, candidate spending, and the normalization of high-cost campaigning. These conditions allow older candidates—who are more likely to possess greater financial resources—to outcompete younger challengers, limiting youth descriptive representation and alienating youth from electoral politics. We conclude that youth underrepresentation is sustained less by overt legal barriers than by embedded systemic inequalities in campaign finance, an issue with broader implications for electoral integrity, representative democracy, and youth voter turnout in the United States.

Bridging The Gap: Why Circulating Micrornas Have Yet To Become Clinical Biomarkers For Endometriosis, Anisha Addepalli, Mary C. Boyes

UROP Posters

Endometriosis is a chronic inflammatory disorder in which endometrial-like tissue grows  outside the uterus, leading to pelvic pain, infertility, and diagnostic delays due to the current  reliance on invasive laparoscopy. Although imaging and hormonal assays offer limited accuracy in diagnosing the disease, circulating microRNAs (miRNAs) in arterial blood have emerged as a  promising alternative method as noninvasive biomarkers because they regulate gene expression,  reflect inflammatory and angiogenic pathways, and remain stable in circulation. I propose  investigating miRNAs such as miR-17-5p, miR-451a, and the let-7 family because of their direct  involvement in the regulation of processes such as cell proliferation, immune …

Antiestrogens As Bone Protective Therapeutics For Estrogen Receptor-Positive Breast Cancer In The Presence Of Osteoporosis, Faith E. Parker, Emily K. Zboril, David C. Boyd, Rachel Myrick, J. Chuck Harrell

UROP Posters

Breast cancer (BC) is one of the most significant causes of mortality among women and the second leading cause of cancer death in women. The estrogen receptor (ER) is a key oncogenic driver in the majority of breast cancer. ER+ BC is the most common molecular subtype of BC. Management of ER+ breast cancer varies depending on menopausal status. For premenopausal women, the goal is to suppress estradiol production from the ovaries with surgical oophorectomy and/or aromatase inhibitors. In postmenopausal women, endocrine therapy (ET) serves to suppress estradiol production from sources other than the ovaries. During the menopausal transition, estradiol …

The Gendered Heart: Closing The Gender Gap In Heart Disease Diagnosis And Treatment, Aiden Varghese

UROP Posters

Cardiovascular disease (CVD) continues to be the primary cause of death for both men and women in the United States, being characterized and treated in a historically male-centric manner. This research paper will address the disparities in risk factors for heart disease between genders, gender differences in diagnosis, and gender differences in management/treatment, thereby demonstrating the critical importance of incorporating sex specific factors into the field of cardiology. It has been demonstrated that lifestyle changes such as physical activity and smoking cessation can reduce CVD risk universally. This signifies a necessary shift toward being proactive in the prevention of CVD. …

Library News January 2026, Research Medical Library

Library News 2026

• Update on NIH Common Forms Implementation
• Looking Back: The Most Popular Library News Articles of 2025
• Using Copilot Chat Effectively and Responsibly in Scientific Writing
• Further Your Knowledge of "Further" and "Farther"

Managing The Legacy Of Historical Land Use In Central Appalachia: Soil Health, Carbon Storage, And Restoration Across Disturbed Ecosystems, Kyra R. Dukich

Graduate Theses, Dissertations, and Problem Reports (ETD)

Historical mining, intensive timber harvesting, agriculture, and atmospheric acid deposition have left lasting impacts on soil health throughout the Central Appalachian region, reducing soil productivity, carbon storage, and ecosystem resilience. This thesis evaluated restoration strategies across two long-term research systems in West Virginia to determine how land-use history and soil amendments influence soil health, carbon dynamics, and ecosystem recovery. The first study examined reclaimed mine lands and marginal agricultural soils planted with switchgrass (Panicum virgatum) or willow (Salix spp.) and treated with biochar or inorganic fertilizer. Soil greenhouse gas production, aggregate stability, total soil C:N, pH, and soil organic matter …

Technology-Driven Approaches For Invasive Species Detection And Management, Kushal Naharki

Graduate Theses, Dissertations, and Problem Reports (ETD)

Invasive species pose significant ecological, economic, and management challenges globally. Purple loosestrife (Lythrum salicaria), Japanese knotweed (Fallopia japonica), tree of heaven (Ailanthus altissima), and mile-a-minute (Persicaria perfoliata) are widespread invasive plants across the eastern United States and present persistent challenges, particularly in remote and inaccessible landscapes. Effective management of these species requires an integrated approach that combines early detection, targeted intervention, public engagement, and spatial modeling. This dissertation used emerging technologies to improve invasive species detection, monitoring, and management.

Unmanned aerial vehicle (UAV)-based platforms equipped with optical sensors were used to establish …

Highly Effective Combination Of Brg1/Brm Inhibitor With Bet Inhibitor Or Decitabine For High-Risk Mecom-Rearranged Aml, Warren Fiskus, Christopher P Mill, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christine E Birdwell, Kaberi Das, John A Davis, Hanxi Hou, Antrix Jain, Anna Malovannaya, Lauren B Flores, Tapan M Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Jian Wang, Sanam Loghavi, Xiaoping Su, Courtney D Dinardo, Ruud Delwel, Kapil N Bhalla

Faculty, Staff and Students Publications

In AML with 3q26.2 rearrangements (r) the distal GATA2 hematopoietic enhancer becomes aberrantly relocated leading to activation of EVI1 expression. EVI1 is a transcriptional regulator that plays a role in proliferation and maintenance of a stem cell-like phenotype in AML. BRG1 (SMARCA4) and BRM (SMARCA2) are the mutually exclusive ATPases of the BAF (BRG1/BRM-associated factor) chromatin remodeling complexes. They regulate access to enhancers/promoters and gene-expressions orchestrating AML stem/progenitor cell proliferation and differentiation. AML with 3q26.2 rearrangements are clinically challenging and prognosis remains very poor. FHD-286 is an orally bioavailable, selective inhibitor of BRG1/BRM under clinical development in AML. Present studies …

Assessment Of In-Frame Indel Variants In An Unsolved Cohort Of Inherited Retinal Diseases Using Machine Learning, David E Rauch, Meng Wang, Muhammad Jafar Hussain Hafiz, Daniel C Brock, Yumei Li, Molly Marra, Mark E Pennesi, Paul Yang, Everett Lesley, Irma Lopez, Robert Koenekoop, Edward Ryan Collantes, Joanne Bolinao, Rui Chen

Faculty, Staff and Students Publications

The standard for in silico pathogenicity prediction of in-frame insertions and deletions (indels) is less established compared to other types of variations. We aimed to systematically assess the performance of in silico machine learning (ML) tools on a patient cohort with inherited retinal diseases (IRDs). The performance of four ML tools (CADD, FATHMM-indel, VEST4, and MetaRNN-indel) was compared. Among them, MetaRNN-indel showed the best overall results. MetaRNN-indel was then applied to 1013 unsolved IRD patients, identifying two likely pathogenic causal variants in two unrelated IRD patients by confirming clinical phenotypes. Hence, our findings indicate that reliable prediction of the pathogenicity …

Clinicians’ Views On A Patient Decision Aid For Deep Brain Stimulation In Parkinson’S Disease, Hillary S King, Jennifer Blumenthal-Barby, Benjamin H Levi, Sol De Jesus, Harini Sarva, Laura Y Cabrera

Center for Medical Ethics and Health Policy Staff Publications

Introduction: For people with Parkinson's disease (PD), deciding whether to pursue deep brain stimulation (DBS) has become increasingly complex. Evidence suggests current approaches to collaborative decision-making may fall short of accepted standards. Thus, a decision support intervention, such as a patient decision aid (PtDA) may be warranted. PtDAs have been shown to improve patients' knowledge, expectations, and participation in decision-making for other, similar healthcare decisions. We therefore sought to assess neurologists' awareness of, and experience using, PtDAs, and to solicit their opinions on the ideal features of a PtDA for PD patients considering DBS.

Methods: Sixteen United States-based neurology clinicians …

Spatial Evolution In Temporal Dynamics Of Hemodynamic Response Function In Human Superior Colliculi With Ultra-High-Resolution Mri At 9.4t, Nooshin J Fesharaki, Artemy Vinogradov, David Ress, Jung Hwan Kim

Faculty, Staff and Student Publications

The superior colliculus (SC) plays a crucial role in multisensory integration, visual information processing, saccadic target selection, visual selective attention, and decision making. In particular, the SC has a key role in oculomotor coordination, following a rostro-caudal organization. The rostral SC, which corresponds to foveal representation, is linked to fixation, microsaccades, smooth pursuit, and vergence adjustments. In contrast, the caudal SC, representing more peripheral visual field, is associated with the large gaze shifts (saccades). However, evidence regarding whether this functional gradient is preserved in the human SC remains limited. In this study, we employed a sequence-following visual-motor task to specifically …

Access To Digital Health Technologies: Personalized Framework And Global Perspectives, Sanjiv M Narayan, Mina K Chung, Demilade Adedinsewo, Luisa C C Brant, Leslie L Davis, David Duncker, Jennifer L Hall, Janet K Han, Carolyn S P Lam, Eldrin Lewis, Joseph Loscalzo, Manlio F Márquez, Vasiliki Rahimzadeh, Fatima Rodriguez, Prashanthan Sanders, Emma Svennberg, Kenneth Stein, Mintu Turakhia, Clyde Yancy, Antonis A Armoundas

Center for Medical Ethics and Health Policy Staff Publications

The emergence and rapid adoption of digital health technologies (DHT) present unprecedented opportunities to democratize and reduce disparities in health care by monitoring health and disease at the point of care in all patients. However, limited access to DHT is becoming a major obstacle to realizing these goals. Access to DHT is influenced not only by well-recognized social determinants of health, but also by digital determinants of health, such as digital literacy and the need for broad access to digital infrastructure, as well as commercial and economic factors. Addressing these challenges and designing unbiased systems of care are essential to …

Clinical Informatics Education To Advance Learning Health Systems: A Scoping Review, Alexandra Zingg, L Ida Tovar, Laura Witte, Kelsey L Koym, Kyler Godwin

Library Staff Publications

Introduction: Learning health systems leverage clinical data and knowledge to advance healthcare quality. Effective training in informatics concepts and tools is essential for medical trainees to become health system experts and contributors to positive organizational change. The objective of this study is to summarize characteristics of existing clinical informatics training programs and map these to recommended Learning Health System informatics competencies. We aim to answer the following research questions: (1) How are academic medical institutions implementing informatics education initiatives for medical trainees? (2) Are these initiatives implementing recommended informatics competencies? and (3) How effective are these initiatives according to established …

Genome-Wide Gene-Sleep Interaction Study Identifies Novel Lipid Loci In 732,564 Participants, Raymond Noordam, Wenyi Wang, Pavithra Nagarajan, Heming Wang, Michael R Brown, Amy R Bentley, Qin Hui, Aldi T Kraja, John L Morrison, Jeffrey R O'Connel, Songmi Lee, Karen Schwander, Traci M Bartz, Lisa De Las Fuentes, Mary F Feitosa, Xiuqing Guo, Xu Hanfei, Sarah E Harris, Zhijie Huang, Mart Kals, Christophe Lefevre, Massimo Mangino, Yuri Milaneschi, Peter J Van Der Most, Natasha L Pacheco, Nicholette D Palmer, Varun Rao, Rainer Rauramaa, Quan Sun, Yasuharu Tabara, Dina Vojinovic, Yujie Wang, Stefan Weiss, Qian Yang, Wei Zhao, Wanying Zhu, Md Abu Yusuf Ansari, Hugues Aschard, Pramod Anugu, Themistocles L Assimes, John Attia, Laura D Baker, Christie Ballantyne, Lydia Bazzano, Eric Boerwinkle, Brain Cade, Hung-Hsin Chen, Wei Chen, Yii-Der Ida Chen, Zekai Chen, Kelly Cho, Ileana De Anda-Duran, Latchezar Dimitrov, Anh Do, Todd Edwards, Tariq Faquih, Aroon Hingorani, Susan P Fisher-Hoch, J Michael Gaziano, Sina A Gharib, Ayush Giri, Mohsen Ghanbari, Hans Jörgen Grabe, Mariaelisa Graff, C Charles Gu, Jiang He, Sami Heikkinen, James Hixson, Yuk-Lam Ho, Michelle M Hood, Serena C Houghton, Carrie A Karvonen-Gutierrez, Takahisa Kawaguchi, Tuomas O Kilpeläinen, Pirjo Komulainen, Henry J Lin, Gregorio V Linchangco, Annemarie I Luik, Jintao Ma, James B Meigs, Joseph B Mccormick, Cristina Menni, Ilja M Nolte, Jill M Norris, Lauren E Petty, Hannah G Polikowsky, Laura M Raffield, Stephen S Rich, Renata L Riha, Thomas C Russ, Edward A Ruiz-Narvaez, Colleen M Sitlani, Jennifer A Smith, Harold Snieder, Tamar Sofer, Botong Shen, Jingxian Tang, Kent D Taylor, Maris Teder-Laving, Rima Triatin, Michael Y Tsai, Henry Völzke, Kenneth E Westerman, Rui Xia, Jie Yao, Kristin L Young, Ruiyuan Zhang, Alan B Zonderman, Xiaofeng Zhu, Jennifer E Below, Simon R Cox, Michelle Evans, Myriam Fornage, Ervin R Fox, Nora Franceschini, Sioban D Harlow, Elizabeth Holliday, M Arfan Ikram, Tanika Kelly, Timo A Lakka, Deborah A Lawlor, Changwei Li, Ching-Ti Liu, Reedik Mägi, Alisa K Manning, Fumihiko Matsuda, Alanna C Morrison, Matthias Nauck, Kari E North, Brenda Wjh Penninx, Michael A Province, Bruce M Psaty, Jerome I Rotter, Tim D Spector, Lynne E Wagenknecht, Ko Willems Van Dijk, Lifelines Cohort Study, Million Veteran Program, Cashell E Jaquish, Peter Wf Wilson, Patricia A Peyser, Patricia B Munroe, Paul S De Vries, W James Gauderman, Yan V Sun, Han Chen, Clint L Miller, Thomas W Winkler, Dabeeru C Rao, Susan Redline, Diana Van Heemst

Faculty, Staff and Student Publications

Background and aims: Deviations from the population mean in sleep duration have been associated with increased risk for developing dyslipidemia and atherosclerotic cardiovascular disease, but the mechanism of effect is poorly characterized. We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels to identify genetic variants underpinning the biomolecular pathways of sleep-associated lipid disturbances and to suggest possible druggable targets.

Methods: We collected data from 55 cohorts with a combined sample size of 732,564 participants (87 % European ancestry) with data on lipid traits (high-density lipoprotein [HDL-c] and low-density lipoprotein [LDL-c] cholesterol and triglycerides [TG]). Short (STST) and long (LTST) …

Limosilactobacillus Reuteri Alleviates Proinflammatory T-Cell-Mediated Liver Injury And Transcriptomic Changes In Immunocompromised Mice, Ana Fadhel Alvarez, Zheng Yin, Beanna Okeugo, Alexander Banerjee, Meng Luo, Christopher M Taylor, Salomea Giorgberidze, Vaishali Harne, Rambabu Majji, Melissa N Munroe, Ji Ho Suh, Stephen T C Wong, Kang Ho Kim, Hari Krishna Yalamanchili, Suhair Al Salihi, Jon Marc Rhoads, Yuying Liu

Children’s Nutrition Research Center Staff Publications

Background: A deficiency of immunosuppressive regulatory T cells, as seen in scurfy (SF) mice or in IPEX syndrome in humans, can lead to multiorgan inflammation. Oral administration of the probiotic Limosilactobacillus reuteri Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM) 17938 prolongs survival and reduces Th1- and Th2-associated inflammation in SF mice. It remains unclear how DSM 17938-educated SF-CD4+ T cells modulate T-cell-liver communication.

Methods: To characterize CD4+ T cells from SF mice orally administered DSM 17938 (Prob-SF-CD4+ T cells) and to compare them with CD4+ T cells from SF mice (SF-CD4+ T cells), cells isolated from SF spleens were …

Insulinemic And Inflammatory Dietary Patterns And Colorectal Cancer Risk: A Dietary Data Harmonization Study Of One Million Participants In The Consortium Of Metabolomics Studies (Comets), Ni Shi, Rachel Hoobler, Rhea Harewood, Amanda E Toland, Demetrius Albanes, Emmanouil Bouras, Marc J Gunter, Linda M Liao, Steven C Moore, Fulvio Ricceri, Jerome I Rotter, Rashmi Sinha, Rachael Stolzenberg-Solomon, Anne Tjønneland, Alexis C Wood, Danxia Yu, Mary C Playdon, Fred K Tabung

Children’s Nutrition Research Center Staff Publications

Background: Inflammatory and insulinemic dietary patterns have been associated with colorectal cancer (CRC) risk, but generalizability across diverse populations with heterogeneous food supplies and dietary behaviors has not been established.

Objectives: We harmonized disparate dietary and covariate data on a large scale to compute the reverse Empirical Dietary Index for Hyperinsulinemia (rEDIH), reverse Empirical Dietary Inflammatory Pattern (rEDIP), and Healthy Eating Index (HEI)-2015 scores, and tested their associations with CRC risk.

Methods: We leveraged data among 501,892 women and 407,390 men from 6 cohorts across the United States (NIH-AARP, Multi-Ethnic Study of Atherosclerosis, Prostate, Lung, Colorectal, and Ovarian, SCCS) and …

Artem: Enhancing Large Language Model Agents With Spatial-Temporal Episodic Memory, Cassandra Hui Ming Tan, Budhitama Subagdja, Ah-Hwee Tan

Research Collection School Of Computing and Information Systems

Current large language models (LLMs) exhibit significant deficiencies in episodic memory tasks including encoding, storing, and retrieving specific information from temporally dependent events over a long period of time. Recent approaches to handle memory tasks in LLMs, such as in-context learning, retrieval-augmented generation (RAG), and fine-tuning, may resolve the long-term retention issues, but are still inadequate to handle tasks requiring chronological awareness of the stored information. We introduce Agentic Retrieval with Temporal-Episodic Memory (ARTEM), a hybrid LLM-based agent architecture integrating LLMs with a self-organizing neural network named Spatial-Temporal Episodic Memory (STEM), designed to handle episodic memory tasks. Our approach employs …

Llamoco: Instruction Tuning Of Large Language Models For Optimization Code Generation, Zeyuan Ma, Yue-Jiao Gong, Hongshu Guo, Jiacheng Chen, Yining Ma, Zhiguang Cao

Research Collection School Of Computing and Information Systems

Recently, combining the strength of large language models (LLMs) and Evolutionary Computation (EC) has shown promising results for addressing optimization problems. It typically involves either iterative next-step solution seeking or directly prompting LLMs to generate critical optimization codes. However, these methods often suffer from low computational efficiency, high sensitivity to prompt design, and a lack of domain-specific knowledge. We introduce LLaMoCo, the first instruction-tuning framework designed to adapt LLMs for solving optimization problems in a code-to-code manner. LLaMoCo features a comprehensive instruction set that includes code-style problem descriptions as input prompts and robust optimization codes from expert EC optimizers as …

Realign: Text-To-Motion Generation Via Step-Aware Reward-Guided Alignment, Wanjiang Weng, Xiaofeng Tan, Junbo Wang, Guo-Sen Xie, Pan Zhou, Hongsong Wang

Research Collection School Of Computing and Information Systems

Text-to-motion generation, which synthesizes 3D human motions from text inputs, holds immense potential for applications in gaming, film, and robotics. Recently, diffusion-based methods have been shown to generate more diversity and realistic motion. However, there exists a misalignment between text and motion distributions in diffusion models, which leads to semantically inconsistent or low-quality motions. To address this limitation, we propose Reward-guided sampling Alignment (ReAlign), comprising a step-aware reward model to assess alignment quality during the denoising sampling and a reward-guided strategy that directs the diffusion process toward an optimally aligned distribution. This reward model integrates step-aware tokens and combines a …

Cross-Modal Proxy Evolving For Ood Detection With Vision-Language Models, Hao Tang, Yu Liu, Shuanglin Yan, Fei Shen, Shengfeng He, Jing Qin

Research Collection School Of Computing and Information Systems

Reliable zero-shot detection of out-of-distribution (OOD) inputs is critical for deploying vision-language models in open-world settings. However, the lack of labeled negatives in zero-shot OOD detection necessitates proxy signals that remain effective under distribution shift. Existing negative-label methods rely on a fixed set of textual proxies, which (i) sparsely sample the semantic space beyond in-distribution (ID) classes and (ii) remain static while only visual features drift, leading to cross-modal misalignment and unstable predictions. In this paper, we propose CoEvo, a training- and annotation-free test-time framework that performs bidirectional, sample-conditioned adaptation of both textual and visual proxies. Specifically, CoEvo introduces a …