Digital Commons Network^™

Crispr-Cas9 Unleashed: Gene-Slicing Adventures In The Cancer Battlefield, Shivakuma Sonnaila, Shilpi Agrawal

Chemistry & Biochemistry Faculty Publications and Presentations

Cancer, a global health menace, continues to pose significant challenges in terms of incidence and mortality, necessitating innovative therapeutic strategies. Despite existing treatments, the limitations persist, prompting a quest for novel approaches. The emergence of immunotherapy marked a transformative era in solid tumor treatments, yet its efficacy is constrained by adverse effects. Concurrently, the integration of advanced technologies into cancer treatment explores the vast potential residing at the molecular level through gene analysis and manipulation. This review articulates the role of state-of-the-art genome editing technology, notably clustered regularly interspaced short palindromic repeats (CRISPR-Cas9), in overcoming the constraints of immunotherapy for …

Agile And Lean Frameworks For Enhancing Accountability And Efficiency In Public Financial Management Systems In Emerging Economies, Mercy Amuna, Eunice Acheabea Offei, Omowumi Folorunso, Charles Zormelo

Student Publications

Findings: This review reveals that Agile and Lean frameworks dramatically improve public financial management by improving fiscal accountability, budgeting efficiency, and service delivery. Drawing on 49 studies published between 2010 and 2025, the majority from emerging economies with selected comparative OECD cases, budgeting and procurement reforms emerged as the dominant sectors analysed. Agile’s iterative and adaptive approach allows governments to make real-time adjustments to budgets, enhancing the economy’s response to economic developments and crises. They focus on reducing waste and financial planning to ensure that public funds are allocated efficiently and effectively. Similarly, Rwanda and Nigeria demonstrate the benefits of …

Moringa Oleifera As An Immunomodulator, Noha Swilam, Khaled A. Nematallah, Omayma Eldahshan'

Pharmacy

Moringa oleifera has gained increasing attention for its diverse pharmacological properties, including its potential to modulate immune responses. This chapter explores the immunomodulatory potential of M. oleifera, exploring both its phytochemical composition and experimental evidence from in vitro and in vivo studies. Key bioactive constituents, such as flavonoids (quercetin, kaempferol, apigenin), phenolic acids (chlorogenic, ferulic, caffeic), glucosinolates (glucomoringin) and their hydrolysis product, benzyl isothiocyanate, are identified as contributors to its immune-regulating properties. It has been demonstrated that these substances affect cytokine expression, suppress pro-inflammatory mediators, increase phagocytic activity and alter lymphocyte reactions. In order to support the plant's traditional use …

Role Of Plants And Phytochemicals In Promoting Proliferation And Osteogenic Differentiation Of Dental Mesenchymal Stem Cells: A Comprehensive Review, Hala El-Zahar, Essam Abdel-Sattar, Marwa Yousry Moustafa Issa, Shereen N. Raafat, Noha Swilam

Pharmacy

Abstract Objectives Dental mesenchymal stem cells (MSCs) represent a promising source for regenerative medicine due to their accessibility and capacity to differentiate into osteoblasts and other lineages. Osteogenic differentiation of dental MSCs is essential for bone formation and is regulated by multiple signaling pathways, cytokines, growth factors, and transcription factors. This review aims to summarize the effects of plant-derived extracts and phytochemicals on the proliferation and osteogenic differentiation of dental MSCs. Methods In this review, an extensive literature search was conducted covering studies from the past 10 years, using different online databases (SCOPUS, Google Scholar, PubMed, Web of Science, Science …

High School Daze, Sylvia Perez, And La Llorona, Manuel F. Medrano

History Faculty Publications

No abstract provided.

El Valle Del Rio Grande – From Carromatos To Spaceships, Manuel F. Medrano

History Faculty Publications

No abstract provided.

Using Data To Identify Gaps And Improve Institutional Collecting In Public University Archives, Hannah Pryor

Faculty and Staff Scholarship

This article describes a project undertaken to assess the university records held by Archives & Special Collections at the University of Louisville. The intention was to identify potential gaps in permanent university records and other university records that fall under relevant collection policies, such as those documenting faculty, staff, and student life. This project included generating a report of accession records in ArchivesSpace, conducting data cleanup, coding qualitative data, creating visualizations, and analyzing findings, with the aim of prioritizing outreach to university units and assisting with future backlog processing and reappraisal. The findings identify ways to improve records management and …

Knowledge Regarding Cervical Cancer Among Adults Studying In A Selected Institution In Mandya District, Karnataka: A Descriptive Study, Megha Maria Joy, Nikitha R, Anitha Victoria Noronha

Manipal Journal of Nursing and Health Sciences

Introduction: Cervical cancer remains a major public health concern, particularly in low- and middle-income countries. Adequate knowledge regarding cervical cancer, its etiology, prevention, and screening is essential for early detection and reduction of disease burden. Objectives: This study aimed to assess the knowledge regarding cervical cancer among adults studying in a selected institution in Mandya District, Karnataka, and to determine the association between knowledge levels and selected demographic variables. Methods: A descriptive cross-sectional design was adopted among 60 adults selected through simple random sampling. Data were collected using a validated structured knowledge questionnaire administered through Google Forms. …

Academics’ Experiences Of Work-Life Balance And Work-Life Conflict In A Familialist State: The Case Of Bosnia And Herzegovina, Sara Clavero, Caitriona Delaney

Research Outputs: 2025-Present

Background: This paper explores how women academics in Bosnia and Herzegovina (BiH) navigate work-life conflict and the main strategies they deploy to balance their work and personal lives. It examines the range of institutional support available to them and assesses their effectiveness in facilitating work-life balance and reducing work-life conflict. Methods: Drawing on 12 semi-structured interviews with female academics at various career stages from public and private universities across BiH, this study captures personal narratives of managing work and caregiving responsibilities. Results: Thematic analysis revealed the respondents’ personal strategies to find work-life balance while trying to achieve their career goals, …

Bridging Divides In The Twin Transition: Governance For Equity And Inclusion, Olga Kolotouchkina, Paloma Piqueiras, Sara Clavero

Research Outputs: 2025-Present

This thematic issue critically engages with the complexities and challenges of the governance of the twin transition through the lens of inclusion and social justice. Scholars and practitioners from Belgium, Ireland, Portugal, Spain, Sweden, and Taiwan examine the origins, determinants, and dynamics of inequalities associated with the twin transition process across different contexts and policy domains. The contributions highlight key governance challenges, identify emerging forms of vulnerability, and bring into focus opportunities to ensure that no one is left behind in the ongoing technological and sustainable transformation.

Senolytic-Resistant Senescent Cells Have A Distinct Sasp Profile And Functional Impact: The Path To Developing Senosensitizers, Utkarsh Tripathi, Masayoshi Suda, Vagisha Kulshreshtha, Bryan T Piatkowski, Allyson K Palmer, Nino Giorgadze, Christina Inman, Nathan Gasek, Ming Xu, Kurt O Johnson, Tamar Pirtskhalava, Selim Chaib, Larissa P G Langhi Prata, Yi Zhu, Renuka Kandhaya-Pillai, Stefan G Tullius, Saranya P Wyles, Rambabu Majji, Hari Krishna Yalamanchili, David B Allison, Tamar Tchkonia, James L Kirkland

Faculty, Staff and Students Publications

The senescent cell (SC) fate is linked to aging, multiple disorders and diseases, and physical dysfunction. Senolytics, agents that selectively eliminate 30%-70% of SCs, act by transiently disabling the senescent cell antiapoptotic pathways (SCAPs), which defend those SCs that are proapoptotic and pro-inflammatory from their own senescence-associated secretory phenotype (SASP). Consistent with this, a JAK/STAT inhibitor, Ruxolitinib, which attenuates the pro-inflammatory SASP of senescent human preadipocytes, caused them to become "senolytic-resistant". Administering senolytics to obese mice selectively decreased the abundance of the subset of SCs that is pro-inflammatory. In cell cultures, the 30%-70% of human senescent preadipocytes or human umbilical …

Look-Ahead Cyber-Threat Forecasting For Connected And Automated Transport: A Spatio-Temporal Graph Learning Approach, Md Al Amin, Mohammad Shafat Ahsan, Jannatul Maua, Arifa Akter Eva, M.F. Mridha, Md. Jakir Hossen

Student Publications [Scholarly]

Modern intelligent transportation systems (ITS) increasingly rely on connected electronic control units (ECUs), exposing in-vehicle networks to cyber-attacks such as message injection on the Controller Area Network (CAN) bus. While prior work has focused on post-factum detection, this paper addresses the underexplored task of forecasting cyber-attacks before they occur. We propose a spatio-temporal graph neural network (STGNN) architecture that models CAN traffic as a dynamic graph sequence, where nodes represent active CAN IDs and edges capture statistical co-activation patterns. Each graph snapshot encodes temporal features such as inter-arrival statistics and entropy, and is processed using graph attention layers followed by …

Attention-Based Geo–Textual Fusion Network For Disaster Risk Prediction, Mohammad Shafat Ahsan, Mst Sanjida Alam, Syed Sajjad Ahmed, Md Tanzimul Islam, Hashibul Ahsan Shoaib, M.F. Mridha, Md. Jakir Hossen

Student Publications [Scholarly]

Natural disasters pose recurring threats to human life and infrastructure, demanding intelligent systems that can process heterogeneous data streams and provide actionable insights in real time. Existing approaches often treat textual signals from social media and emergency communications separately from spatial hazard attributes, limiting their effectiveness in capturing the full complexity of evolving crises. This paper proposes an AI-driven geo–textual intelligence framework that integrates disaster-related text with GIS-based hazard features for real-time risk prediction and evacuation planning. The framework employs contextual text encoders and a neural GIS encoder, fused through an attention mechanism that dynamically weights cross-modal signals. Experiments on …

Self-Compassion And Sexual Assault Victimization: A Systematic Review, Alexis A. Adams-Clark, Jerin Lee, Lucy W. Naughton, Anna Purcell, Ananya Sharma, Siena Candullo, Kelsey Sawyer, Prachi H. Bhuptani, Lindsay M. Orchowski

Student Publications [Scholarly]

Sexual assault survivors demonstrate substantial resilience, prompting calls for strength-based approaches to understanding recovery. One construct receiving increasing attention is self-compassion (i.e., treating oneself with kindness and understanding in the face of suffering), which may buffer against the negative mental health effects of assault victimization. The current systematic review synthesized data from 31 peer-reviewed studies examining self-compassion, sexual assault exposure, and mental health. Reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards and registered in PROSPERO (CRD420250648494), the review included observational and experimental studies assessing sexual assault victimization and self-compassion across the lifespan. Most studies …

Modeling And Performance Evaluation Of Machine Learning For Historical And Future Land Use And Land Cover Dynamics In Chattogram District, Bangladesh, Mst Sanjida Alam

Student Publications [Scholarly]

Introduction – Land use and land cover (LULC) change is rapidly redrawing the environmental landscape of coastal Bangladesh. Methods – This study integrates Landsat-based classification, machine learning-based approaches, and Markov Chain simulation to assess historical and future LULC dynamics in Chattogram District. Results – Random Forest classification achieved overall accuracies of 95.96%, 90.45%, and 94.25% for 2006, 2015, and 2025, respectively. Results reveal substantial cropland expansion (+32, 375 ha) and continued growth of built-up land, accompanied by declines in vegetation, waterbodies, and bare land. Random Forest demonstrated strong predictive performance, achieving an out-of-bag (OOB) accuracy of 92.63% and a skill …

“I Have Already Lost My Kids”: Mothering Experiences Of Women In Jail, Bothwell Piason, Dawn Beichner-Thomas

Faculty Publications - Criminal Justice Sciences

Although women represent a small proportion of the incarcerated population globally, their rate of incarceration in the United States has increased dramatically over the past four decades, outpacing that of men. As carceral trends return to pre-COVID-19 pandemic levels, jail populations continue to rise, with most incarcerated women being mothers of young children. Yet, research on motherhood behind bars has largely focused on prisons rather than jails. This study explores the mothering experiences of women incarcerated in two U.S. Midwestern jails, including both pretrial detainees and sentenced individuals. Using qualitative data from in-depth interviews with jailed mothers, the analysis examines …

Innocence Interrupted: A 25-Year Study Of Reported Filicide Incidents In The United States, 1999 To 2023, Jeffrey A. Walsh, Jessie L. Krienert, Ema Voksic

Faculty Publications - Criminal Justice Sciences

This study examines filicide, the killing of a child by a parent or parental figure, using 25 years of data (1999–2023) from the National Incident-Based Reporting System (N = 3,974). Multinomial logistic regression was used to analyze variations in offender, victim, and incident characteristics across four victim age categories: neonaticide (within 24 hr of birth), infanticide (1–364 days), child filicide (1–17 years), and adult filicide (18+ years). Results reveal significant differences in offender age, sex, race, weapon use, and victim demographics. Neonaticide is most often associated with younger female offenders and the use of personal weapons, while adult filicide …

'Punishing Death Dealers': Examining Claims To Expand The Death Penalty To People Who Deal Drugs, Joshua H. Stout

Faculty Publications - Criminal Justice Sciences

In 1988, the Anti-Drug Abuse Act authorized the use of the death penalty for individuals who committed murder while involved in certain federal drug crimes. In recent years, as America has grappled with rising opioid overdose deaths, there has been an increase in calls for expanding murder charges and capital punishment for individuals who deliver drugs that result in an overdose death. Utilizing content analysis of news media and presidential speeches, this paper explores the claims-making process surrounding the arguments in favor of sentencing people who deal drugs to death during the 1980s and the contemporary opioid crisis. Findings demonstrate …

“… It's Google That's Big Brother”: The Symbiosis Between Icac Investigators And The Private Sector Regarding Encryption And Privacy, Christopher G. Brewer, Kevin F. Steinmetz, Don Kurtz, Brian Schaefer

Faculty Publications - Criminal Justice Sciences

Encryption technologies have become ubiquitous for both individual and commercial sectors. Perhaps no realm of law enforcement is so acutely affected by encryption than cybercrime, including internet crimes against children (ICAC) personnel. There exist a variety of encryption-based tools and authentication measures available to help online child sexual abusers and consumers of child sexual abuse material (CSAM) hide their activities and obstruct law enforcement efforts to gather evidence of criminal activity. Established here is the idea that ICAC investigative practice is ultimately shaped by these technologies as well as the relationship between the distributors of these technologies and private platforms …

“If You Think This Vilifies The Police, Then You Think The Police Are Villains”: Teaching Reparations Won As An Antidote To Copaganda, Kaitlyn Selman, Hannah Carson Baggett, Justin Turner

Faculty Publications - Criminal Justice Sciences

Building on prior research about copaganda and pro-police socialization, we argue that the Reparations Won curriculum in Chicago Public Schools is an antidote to police legitimization efforts in K-12 schools. Specifically, the curriculum affirms student experiences that are not accounted for nor deemed possible in a world built by and for policing; it emphasizes relationship-building and centers definitions of community that resist the alienation required for such a world; and it facilitates an understanding of local histories as inseparable from broader social structures. We conclude that in an era of contested curricula, Reparations Won provides the structure needed to grapple …

Examining The Dynamics Between Criminal Justice Campaign Messaging, News Coverage, Public Policy Mood, And Voter Participation In Judicial Elections, Hayley Munir, Marcy Shieh, Michael Catalano

Faculty Publications - Criminal Justice Sciences

Objective

In low-information elections, any amount of information can be decisive in voter behavior, including the choice of whether to make a choice in each race. In judicial elections, often low-information affairs, rhetoric about criminal justice typically attracts the most attention of potential voters. Given the nature of these judicial races, voter knowledge on candidates relies on a variety of state- and race-level contextual factors, including issues of law and order, a key feature of judicial races as highlighted in campaign advertising. We examine the impact of crime rhetoric in judicial campaign ads, front-page news coverage of criminal cases, and …

Conceptualizing The Receipt Of Unfair School Discipline Through A Betrayal Trauma Lens, Charles Bell, Alexia Angton, Sarah Franklin, Michayla Mack, Pavel Ahmed

Faculty Publications - Criminal Justice Sciences

We contribute to the literature on school discipline by investigating why some Black students, parents, and advocates perceived particular punishments as unfair. Using Betrayal Trauma Theory (BTT) as a framework, we conducted qualitative interviews with twelve Black parents and five community activists who assisted Black children throughout the school discipline process and perceived such punishments as unfair. We also interviewed four Black children who received punishments at school that they perceived as unfair. Participants reported that instances of unfair school punishment created barriers to graduation, criminalized Black students, and permitted victimization to occur on school grounds.

Municipal Budgeting In Times Of Crisis: A Study Of Fiscal Conjunctures In Three U.S. Cities, Mark Davidson, Kevin Ward

Geography

Since the late 1950s and early 1960s, U.S. cities have been associated with various types of crises. Recent decades have been no exception, with the Global Financial Crisis (GFC) and COVID-19 pandemic being external events that severely disrupted U.S. urban fiscal governance. This disruption involves both the generation of new challenges (e.g., housing market declines, social distancing) and a worsening of longstanding urban challenges relating to, for example, housing, inequality, racism, segregation, and so on. This paper focuses on how the internal fiscal governance of three U.S. cities—Buffalo, Nashville, and San Jose—navigated the GFC and COVID-19 pandemic. We find that …

Activity-Dependent Remodeling Of Muscle Architecture During Distinct Locomotor Behaviors In Caenorhabditis Elegans, Adina Fazyl, Akash Anbu, Sabrina Kollbaum, Andres G. Vidal-Gadea

Faculty Publications – Biological Sciences

Muscle structure is dynamically shaped by mechanical use, yet how distinct locomotor behaviors influence sarcomere organization remains poorly understood. In Caenorhabditis elegans, crawling and swimming constitute discrete gaits that differ in curvature, frequency, and mechanical load, providing a tractable model for studying activity-dependent remodeling. Using confocal imaging of phalloidin-stained body-wall myocytes, we quantified myocyte geometry, sarcomere length, and sarcomere number across anterior, mid-body, and posterior regions in animals reared exclusively under crawling or swimming conditions. Quantification and hypothesis testing used linear mixed models that accounted for repeated myocyte measurements within animals, with interaction terms testing region-specific effects of locomotor …

From Classroom To Career: Use Of Digital Collaboration Tools To Bridge Theory & Practice, Della Clark, Kristina Kaufman, Sphurti Sewak, Peter Kaufman, Rick Valentin, Hulda Black

Faculty Publications – Marketing

Teamwork and project management skills, from in-person to remote interactions, remain central to marketing graduates’ career readiness, yet students often complete team projects with limited guidance on how to organize work, especially in hybrid and technology‑mediated environments. This study explores a pilot of integrating Miro, a widely used digital collaboration whiteboard, into classroom student projects. A pre- and post-survey design was implemented across two undergraduate marketing courses at a large Midwestern U.S. university to explore if Miro can improve students’ team‑project experience and perceived preparedness for working with emerging technologies. Students completed a questionnaire at the beginning of the semester …

Startle Habituation And Vagally Mediated Heart Rate Variability Influence The Use Of Emotion Regulation Strategies, Xiao Yang, Fang Fang, Angela Ximena Babb

Psychology Faculty Publications

Emotion regulation refers to the processes through which people modulate their emotional experiences and expressions, and difficulties in these processes underpin many forms of psychopathology. According to the process model, emotion regulation encompasses five classes of strategies, commonly grouped into antecedent-focused strategies (e.g., cognitive reappraisal) and response-focused strategies (e.g., expressive suppression). These strategies involve both explicit and implicit processes, which can be objectively assessed using physiological indices. The present study examined the effects of startle habituation and vagally mediated heart rate variability (vmHRV) on the use of cognitive appraisal and suppression. Forty-nine college-aged participants were recruited, and their resting heart …

Maternal Child Maltreatment And Intimate Partner Violence: Effects On Perceptions Of Infant Temperment And The Mediating Role Of Emotion Regulation And Responsiveness, Jewelian N. Fairchild, G. Anne Bogat, Amy K. Nuttall, Alytia A. Levendosky, Joseph S. Lonstein, Maria Muzik

Psychology Faculty Publications

Purpose

Maternal adverse experiences, such as maltreatment in childhood and later intimate partner violence (IPV) during pregnancy, can disrupt the mother-child relationship and influence maternal perceptions of infant temperament. The present study explored how these adversities influence mothers’ views of their infants’ temperaments and examined the role of maternal emotion regulation and responsiveness to their infants as mediators of these relationships.

Methods

Using data from a longitudinal study of highly stressed, vulnerable women, 355 mothers retrospectively reported on their own childhood maltreatment, as well as their experiences of IPV and emotion regulation during pregnancy. Maternal responsiveness was coded using mother-infant …

Improving Expository Reading Comprehension In College Students, Danielle M. De Lucia, George Noell

Psychology Faculty Publications

This study investigated the impact of the Collaborative Strategic Reading (CSR) method on reading comprehension and psychological well-being among college students, addressing a gap in research on expository reading comprehension at the post-secondary level. A total of 47 students from Introduction to Psychology courses participated in the study. Participants initially completed pre-test assessments, including a cloze test, the Wide Range Achievement Test, and scales for self-worth, depression, anxiety, and stress. Of these, 23 students underwent CSR intervention sessions, conducted over three weeks with bi-weekly 50-minute sessions using their course textbook. Post-intervention data from 44 students were analyzed using repeated-measures ANOVA. …

Advancing Models Of Ptsd-Aud Comorbidity: Protocol For A Multimethod Framework Using Genetics And Ecological Momentary Assessment, Elizabeth A. Stinson, Samhita Lellapalli, Sage E. Hawn, Natalie Merrill, Lance M. Rappaport, Christina M. Sheerin, Vasiliki Michopoulos, Silviu-Alin Bacanu, Roseann E. Peterson, Abigail Powers, Ananda B. Amstadter

Psychology Faculty Publications

Background: Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD), which are moderately heritable, frequently co-occur and contribute to significant public health burdens, particularly among economically disadvantaged urban communities. There are noted sex differences in PTSD and AUD outcomes, with evidence suggesting women have heightened susceptibility to stress-related alcohol use. Preliminary PTSD-AUD ecological momentary assessment (EMA) findings support bidirectional associations across clinical outcomes. However, no studies to date have used PTSD-AUD comorbidity models as organizing frameworks to examine the temporal ordering and stability of within-person symptom dynamics underlying the maintenance or exacerbation of PTSD and AUD symptoms, including bidirectional and …

Establishing Hierarchical Classification Responding: Directly Trained And Emergent Responses, George H. Noell, Kristin A. Gansle, Hannah M. Sliman, Danielle M. De Lucia

Psychology Faculty Publications

Hierarchical classification responding (HCR) describes a collection of responses that require discrimination of logical relationships between stimuli based on their position in a categorical hierarchy. This study established HCR for a new hierarchy in young children through discrete trial instruction. Participants selected pictures corresponding to different hierarchical levels of categorization. We tested for the emergence of naming that matched the level of hierarchy presented, transformation of function, and class inclusion responding for the trained and novel stimuli. Correct responding to the target hierarchy was established and resulted in the emergence of class naming and transformation of function without direct instruction. …