Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Law (5292)
- Social and Behavioral Sciences (3651)
- Arts and Humanities (2989)
- Education (1696)
- Medicine and Health Sciences (1595)
-
- Constitutional Law (1521)
- Physical Sciences and Mathematics (1060)
- Criminal Law (1053)
- Comparative and Foreign Law (989)
- Courts (977)
- Administrative Law (975)
- Human Rights Law (931)
- Business (886)
- Criminal Procedure (885)
- Life Sciences (859)
- Legal Education (849)
- Civil Law (836)
- Internet Law (829)
- Business Organizations Law (821)
- Engineering (815)
- Rule of Law (807)
- Energy and Utilities Law (806)
- Natural Resources Law (805)
- Antitrust and Trade Regulation (788)
- International Trade Law (778)
- Election Law (753)
- Agriculture Law (747)
- Air and Space Law (746)
- Sociology (733)
- Conflict of Laws (732)
- Institution
-
- Universitas Indonesia (990)
- University of Texas at Arlington (898)
- Villanova University Charles Widger School of Law (834)
- Technical Disclosure Commons (526)
- Liberty University (511)
-
- Fordham Law School (437)
- Design Research Society (355)
- Walden University (301)
- City University of New York (CUNY) (265)
- University of Montana (258)
- The Texas Medical Center Library (250)
- Edith Cowan University (209)
- University of Kentucky (194)
- Seton Hall University (186)
- University of South Florida (180)
- TÜBİTAK (173)
- Singapore Management University (172)
- University of Central Florida (166)
- University of Mississippi (158)
- Grand Valley State University (156)
- University of Plymouth (151)
- Old Dominion University (150)
- San Jose State University (149)
- Brigham Young University (148)
- University of South Carolina (145)
- George Fox University (144)
- Purdue University (144)
- University of Memphis (142)
- University of Texas Rio Grande Valley (135)
- Utah State University (135)
- Keyword
-
- Humans (255)
- Artificial intelligence (201)
- Female (121)
- Male (115)
- Education (114)
-
- Animals (110)
- Artificial Intelligence (108)
- AI (101)
- Leadership (93)
- Higher education (84)
- The Repairer (76)
- Machine learning (74)
- United States (73)
- First Amendment (72)
- Tennessee (72)
- Law (71)
- Constitutional law (70)
- History (70)
- Mice (69)
- Gender (65)
- Generative AI (65)
- Mental health (65)
- Supreme Court (60)
- Adult (59)
- Ethics (58)
- Sustainability (58)
- Women (58)
- Religion (56)
- Identity (55)
- Social media (54)
- Publication
-
- 2026 Decisions (785)
- Jurnal Hukum & Pembangunan (734)
- Defensive Publications Series (526)
- Theses and Dissertations (495)
- The Shorthorn Newspaper Collection: 1980s (459)
-
- DRS Biennial Conference Series (339)
- Doctoral Dissertations and Projects (323)
- All Decisions (278)
- Walden Dissertations and Doctoral Studies (271)
- Faculty Scholarship (230)
- Fast Capitalism (227)
- Research outputs 2022 to 2026 (180)
- Faculty Publications (161)
- Dissertations (148)
- Electronic Theses and Dissertations (138)
- Honors Theses (133)
- University of Montana Course Syllabi, 2026-2030 (133)
- Communal Societies (130)
- Faculty, Staff and Students Publications (128)
- Engineering and Technology Journal (127)
- Dissertations, Theses, and Capstone Projects (112)
- Occasional Papers on Religion in Eastern Europe (103)
- Articles (102)
- Masters Theses (101)
- Proche-Orient, Études juridiques (100)
- Theses (94)
- Student Works (86)
- Parameters Bookshelf – Online Book Reviews (85)
- Al-Qadisiyah Medical Journal (81)
- Faculty, Staff and Student Publications (81)
- Publication Type
Articles 21901 - 21930 of 22723
Full-Text Articles in Entire DC Network
Navigating Liminality: Building Resources For And With Undocumented Students, Yaneyry Delfin Martinez
Navigating Liminality: Building Resources For And With Undocumented Students, Yaneyry Delfin Martinez
Cal Poly Humboldt theses and projects
Rooted in Community-Based Participatory Research (CBPR) and Liberation Sociology, this project outlines an institutional blueprint for the resources and support systems needed to address the lived realities of undocumented students at Cal Poly Humboldt (CPH). Conducted during the second Trump Administration amidst escalating hostility towards immigrants and attacks on DEI initiatives, this work documents both the structural conditions shaping undocumented students’ lives and the collective resistance that emerged in response. Furthermore, it examines how immigration policy, access to and restrictions on federal and state aid, geographic conditions, and on-campus barriers reproduce and maintain legal liminality within higher education. Grounded in …
Reclaiming Presence: An Anthropological Study Of Digital Disconnection And Meaning-Making, Leslie De Paz
Reclaiming Presence: An Anthropological Study Of Digital Disconnection And Meaning-Making, Leslie De Paz
Cal Poly Humboldt theses and projects
Human attention is increasingly at risk in an unregulated digital ecosystem where overconsumption shapes neurological function, social interaction, and the ways people make meaning of everyday life. Dominant discourse around digital overuse tends to medicalize the problem, framing it as individual addiction or clinical dysfunction. In this thesis, I argue that such framing obscures what a cultural phenomenon is fundamentally, one in which people are actively questioning their relationship with technology, building awareness, and developing practices that help them slow down and reclaim agency within algorithmically mediated environments. This study draws on 22 semi-structured interviews with Gen Z and millennial …
Don’T Give The Fae Your Name: Focus Of Attention And Victim Blaming, Entropy Cramer
Don’T Give The Fae Your Name: Focus Of Attention And Victim Blaming, Entropy Cramer
Murray State Theses and Dissertations
Victim-blaming is thought to be a result of the fundamental attributional error, where people over-emphasize internal attributions about the victim. Despite this, there is little literature on manipulating the focus of attention and the result for victim-blaming. People who are high in rape myth acceptance tend to visually focus on the victims longer (Süssenbach et al., 2015). Rempala and Bernieri (2005) found that adding irrelevant information, such as height and weight, to the trial about the victim increased victim-blaming compared to when it was absent. The current study investigated if relevant information about the victim and perpetrator changed the amount …
Integrating Human Rights Into State And Federal Court Litigation, Lauren E. Bartlett
Integrating Human Rights Into State And Federal Court Litigation, Lauren E. Bartlett
All Faculty Scholarship
Human rights have never been more important in the United States as they are today. After more than 10 years of dormancy, the seminal work that guides public interest attorneys in incorporating human rights work has been finally updated. The Human Rights in the U.S. Handbook for Public Interest Attorneys is a handbook that provides practical direction to public interest attorneys, including clinical law teachers, legal aid attorneys, public defenders, and others, on how to use human rights in their everyday work. The Handbook invaluably advises attorneys on best practices for using human rights arguments before U.S. state and federal …
Toward A Transformative Church: The Role Of Elders In Church Growth In The Seventh-Day Adventist Church, Brian Kwalela Mungandi
Toward A Transformative Church: The Role Of Elders In Church Growth In The Seventh-Day Adventist Church, Brian Kwalela Mungandi
All Electronic Theses and Dissertations
This study addressed the need for a transformational leadership strategy that engages elders in membership retention and church growth for a Seventh-day Adventist Church. This mixed-method study aimed to identify factors contributing to declining membership in the Seventh-day Adventist Church, with the goal of informing strategies for improved member retention and potential church growth. A survey involving 30 active members was administered to gather insights into the target church’s profile. Additionally, interviews were conducted with 18 elders across four churches to evaluate leadership perspectives concerning membership retention and church growth. These data sources offered a snapshot of the target church's …
The Future Of Crypto-Asset Regulation Under Wto Law, Ines Willemyns
The Future Of Crypto-Asset Regulation Under Wto Law, Ines Willemyns
Vanderbilt Journal of Transnational Law
No abstract provided.
Uncharted Waters: Barriers To Ocean Carbon Removal In The High Seas Under Unclos And The Bbnj, Connor Stevens
Uncharted Waters: Barriers To Ocean Carbon Removal In The High Seas Under Unclos And The Bbnj, Connor Stevens
Vanderbilt Journal of Transnational Law
No abstract provided.
"Donald Trump Is Definitely Fucking Satan": South Park, Media Satire, And Shifting Frames Of Acceptance And Rejection For Two Trump Presidencies, Matt Foy
Iowa Journal of Communication
In light of evolving questions of the role and efficacy of political humor in addressing the exigency of a second Donald Trump presidency, this study analyzes two extended satirical story arcs critical of Trump and MAGA from award-winning adult animated comedy South Park. The study utilizes three of Kenneth Burke’s rhetorical frames of acceptance and rejection (comedy, tragedy, and burlesque) to contrast South Park’s two most substantive satirical statements on Trump and MAGA: Season 19 and 20’s comparatively humane and introspective satire on Trump’s 2015-16 candidacy and Season 27-28’s dehumanizing mockery of Trump’s ongoing second presidency (2025-). The analysis suggests …
Reproducing Audiovisual And Representational Dissonance: Translating Foreign Telenovela Into Twinovela, Nancy A. Frimpong
Reproducing Audiovisual And Representational Dissonance: Translating Foreign Telenovela Into Twinovela, Nancy A. Frimpong
Iowa Journal of Communication
This article examines the production processes and cultural implications of adapting foreign telenovelas into "Twinovela"— serialized foreign dramas dubbed into Akan—on Ghanaian television. Focusing on Adom TV and United Television (UTV), the study explores how dubbing practices challenge traditional notions of indigenous media by merging global and local cultural narratives. Using ethnographic research methods, including interviews, participant observation, and institutional discourses, the analysis delves into recruitment strategies, translational practices, and the creative process of dubbing. The study highlights the sociocultural dynamics of Akan language use, the role of linguistic norms, and the integration of Ghanaian cultural motifs to ensure audience …
A Comprehensive Overview Of Neurophysiological Correlates Of Cognitive Impairment In Amyotrophic Lateral Sclerosis, Seyyed Bahram Borgheai, Brie E. Achorn, Alyssa H. Zisk, Sarah M. Hosni, Karl E. G. Richter, Frank S. Menniti, Yalda Shahriari
A Comprehensive Overview Of Neurophysiological Correlates Of Cognitive Impairment In Amyotrophic Lateral Sclerosis, Seyyed Bahram Borgheai, Brie E. Achorn, Alyssa H. Zisk, Sarah M. Hosni, Karl E. G. Richter, Frank S. Menniti, Yalda Shahriari
Computer Science Faculty Publications
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads to the gradual loss of motor control, typically resulting in paralysis and death within 3 to 5 years of diagnosis. ALS shares neuropathological and genetic associations with fronto-temporal dementia (FTD), a neurodegenerative condition primarily impacting cognitive functions. These two conditions are increasingly viewed as manifestations of a single molecular disease process that affects distinct brain systems, impacting motor neuronal pathways in ALS and fronto-cortical functions in FTD. However, this simple dichotomy belies the complexity of these conditions. In particular, patients with primary motor ALS can also experience significant cognitive …
Quantum Machine Learning Models: Principles, Frameworks, And Computational Challenges, K. A. Jayabalaji, S. Venkata Anand, Dineshkumar Rajendran, Prasanta Chatterjee Biswas, Sardor Omonov, Rubaid Ashfaq
Quantum Machine Learning Models: Principles, Frameworks, And Computational Challenges, K. A. Jayabalaji, S. Venkata Anand, Dineshkumar Rajendran, Prasanta Chatterjee Biswas, Sardor Omonov, Rubaid Ashfaq
Computer Science Faculty Publications
Quantum machine learning (QML) has become an optimistic avenue of harnessing quantum computation in data-driven modeling, especially of issues with high dimensionality and complicated correlations. Current methods are generally based on fixed or over-parameterized quantum circuits, and hence restricted to scalability as well as unproductive optimization in real-world hardware. This chapter introduces a hybrid quantum-classical learning system that is adaptive and provides principled quantum data encoding, architecture-conscious variational circuit design and resource-optimal optimization. The technique is based on the concepts of quantum architecture search and subspace-preserving transformations to trade expressiveness with trainability, and discretize the quantum model into a classical …
The Privacy Paradox Of Llms: User Perceptions And The Reality Of Pii Leakage, Shuai Cheng, Haitao Xu, Shu Meng, Shuai Hao, Chuan Yue, Zhao Li
The Privacy Paradox Of Llms: User Perceptions And The Reality Of Pii Leakage, Shuai Cheng, Haitao Xu, Shu Meng, Shuai Hao, Chuan Yue, Zhao Li
Computer Science Faculty Publications
Large language models (LLMs) are increasingly deployed, yet they introduce significant privacy risks by disclosing personally identifiable information (PII) during interactions. Although prior work has demonstrated the feasibility of extracting PII from LLMs, no comprehensive study has evaluated the actual extent of PII leakage across mainstream LLMs or investigated user perceptions, literacy, and behavioral responses to these risks. To address these gaps, we conduct a large-scale evaluation of PII leakage in popular LLMs, demonstrating that attackers can extract email addresses and phone numbers with high success rates. Through a mixed-methods study involving 20 interviews and 204 survey participants, we identify …
Biosecure-Llm Framework: Protecting Llms From Cyberbiosecurity Threats And The Case For Independent Ai Safety Governance, Xavier-Lewis Palmer, Lucas Potter, Srdjan Lesaja, Sotirios Karathanasis, Mohammad Ghasemigol
Biosecure-Llm Framework: Protecting Llms From Cyberbiosecurity Threats And The Case For Independent Ai Safety Governance, Xavier-Lewis Palmer, Lucas Potter, Srdjan Lesaja, Sotirios Karathanasis, Mohammad Ghasemigol
Computer Science Faculty Publications
Large Language Models (LLMs) are becoming critical infrastructure in scientific, healthcare, and governmental contexts. As frontier AI laboratories increasingly partner with government agencies, a fundamental question arises: Who should control the safety and policy-enforcement layers that constrain model behavior? Current safety mechanisms (LLM guardrails) are typically designed for generic "harmlessness" and operate by detecting semantic patterns and refusing requests. However, they are inadequate governance instruments because they cannot implement auditable, domain-specific controls tied to external regulatory policy objects (e.g., control lists or rules governing personally identifying information). Even a perfectly aligned model is not able to express institution-specific policy without …
Variational Autoencoder Inverse Mapper For Extraction Of Compton Form Factors: Benchmarks And Conditional Learning, Douglas Adams, Md Fayaz Bin Hossen, Joshua Bautista, Gia-Wei Chern, Simonetta Liuti, Marie Boër, Marija Čuić, Michael Engelhardt, Gary R. Goldstein, Huey-Wen Lin, Yaohang Li
Variational Autoencoder Inverse Mapper For Extraction Of Compton Form Factors: Benchmarks And Conditional Learning, Douglas Adams, Md Fayaz Bin Hossen, Joshua Bautista, Gia-Wei Chern, Simonetta Liuti, Marie Boër, Marija Čuić, Michael Engelhardt, Gary R. Goldstein, Huey-Wen Lin, Yaohang Li
Computer Science Faculty Publications
Deeply virtual exclusive scattering processes (DVES) serve as precise probes of nucleon quark and gluon distributions in coordinate space. These distributions are derived from generalized parton distributions (GPDs) via Fourier transform relative to proton momentum transfer. QCD factorization theorems enable DVES to be parameterized by Compton form factors (CFFs), which are convolutions of GPDs with perturbatively calculable kernels. Accurate extraction of CFFs from DVCS, benefiting from interference with the Bethe–Heitler (BH) process and a simpler final state structure, is essential for inferring GPDs. This paper focuses on extracting CFFs from DVCS data using a variational autoencoder inverse mapper (VAIM) and …
Open Scholarly Information Systems: Status Quo, Challenges, Opportunities, Hannah Bast, Guillaume Cabanac, Paolo Manghi, Jian Wu, Marcel R. Ackermann
Open Scholarly Information Systems: Status Quo, Challenges, Opportunities, Hannah Bast, Guillaume Cabanac, Paolo Manghi, Jian Wu, Marcel R. Ackermann
Computer Science Faculty Publications
Over the past 30 years, a rich ecosystem of scholarly information systems has developed that openly provide their services to the scientific community. These systems include aggregators of bibliographic metadata (e.g., DBLP, OpenCitations, OpenAIRE Graph, OpenAlex, ORKG, Semantic Scholar, CiteSeerX, and CORE); publication, data, and software repositories (e.g., Arxiv.org, Figshare, Zenodo, Software Heritage, and Dataverse); and PID authorities (e.g., ORCID, ROR, Crossref, and DataCite). This interdisciplinary Dagstuhl Seminar "Open Scholarly Information Systems: Status Quo, Challenges, Opportunities" (25381) was the first of its kind to bring together practitioners from this ecosystem, as well as researchers investigating related questions or relying on …
Exploit Machina, Andrea Matwyshyn
Exploit Machina, Andrea Matwyshyn
Faculty Scholarship
Over half a century ago, Hannah Arendt cautioned us to “think what we are doing” when we build new technologies. Engaging with her counsel and a set of historical case studies, this Article frames what it calls exploit machina problems. Exploit machina refers to situations where broken technologies and broken governance combine to irreparably harm the public. In other words, exploit machina involves organizational choices to knowingly leverage technology as part of legally problematic conduct, including various forms of fraud. In the language of data science, exploit machina situations implicate strategic decisions in building and managing artificial intelligence (AI); they …
Neuro-Advocacy: Harmonizing Persuasion With The Operation Of The Brain, Gary Gildin
Neuro-Advocacy: Harmonizing Persuasion With The Operation Of The Brain, Gary Gildin
Faculty Scholarship
The most significant contemporary advances in effective courtroom advocacy will emerge from what on the surface is an unlikely source: neuroscience. Revolutionary advances in technology for the first time allow us to see how the human brain makes decisions. The findings are wholly inconsistent with how the trial process presupposes the finder of fact will perceive and use information delivered by lawyers and witnesses. Consequently, lawyers seeking to persuade jurors (and judges) must reframe their advocacy to align with what we have learned about how the minds of these decision-makers will receive testimony and argument and use these inputs to …
George White Family Papers - Accession 1900, White Family
George White Family Papers - Accession 1900, White Family
Manuscript Collection
This collection consists of bound volumes, family Bibles, lecture and financial notebooks, diaries, scrapbooks, photographs, magazines, publications, and memorabilia collected or owned by members of the White family and related families. The White family, descendants of George Pendleton and Ann Hutchinson White, was among the founding families of Rock Hill, South Carolina, and played a significant role in the development and history of the community. The family’s historical presence in Rock Hill is also reflected in the White Home, one of the early homes constructed in the city and now a local historic attraction, and White Street in downtown Rock …
Crypto Exchanges In Market Regulation, Yesha Yadav
Crypto Exchanges In Market Regulation, Yesha Yadav
Vanderbilt Law Review
The cryptocurrency market has proven notoriously challenging to regulate despite a decade during which it has gained in economic size, sophistication, and cultural impact. Even as repeated crises have left ordinary savers wiped out, regulation has shown itself to be woefully absent as a means of mitigating risks ex ante or helping cover the cost of damage ex post. This Article looks to break this deadlock by proposing a tried-and-tested solution: It argues that regulators should task crypto exchanges with providing oversight as self-regulatory organizations of the crypto market in which they play an anchoring role. It offers three supporting …
A Direct Path Should Be Easy To Follow: Reframing The “Direct Effect” Test For Jurisdictional Immunity Under The Foreign Sovereign Immunities Act, Greggory Cashmark
A Direct Path Should Be Easy To Follow: Reframing The “Direct Effect” Test For Jurisdictional Immunity Under The Foreign Sovereign Immunities Act, Greggory Cashmark
Vanderbilt Law Review
As sovereign nations become more involved in international commercial dealings, it becomes more important to establish a reliable and stable framework for resolving disputes with foreign sovereigns. The FSIA is the result of a long historical trend towards establishing that framework. While the FSIA is a step in the right direction, there are a number of interpretive questions regarding where it places the boundaries of a court's jurisdiction over foreign sovereign activity. While these questions remain open and while courts continue to find reasons to keep them open, they undermine the principal purpose of the FSIA: predictability. There is no …
Presidential Immunity: Before And After Trump, Thomas P. Schmidt
Presidential Immunity: Before And After Trump, Thomas P. Schmidt
Vanderbilt Law Review
'All the officers of government," the Supreme Court said long ago, "from the highest to the lowest, are creatures of the law, and are bound to obey it." Despite that ringing and categorical language, however, the Court has held that the President-the "highest" and most powerful of all government officers-is "immune" from judicial oversight in several respects. Indeed, when the Court held last Term that former presidents are presumptively immune from criminal prosecution for officials acts, the dissenters warned: '`n every use of official power, the President is now a king above the law."
This Article unpacks the various presidential …
Voxvista: Enhancing Screen Reading Experience For Online User Comments, Yash Prakash, Akshay Kolgar Nayak, Mohammed Shoaib Alyaan, Sampath Jayarathna, Hae-Na Lee, Vikas Ashok
Voxvista: Enhancing Screen Reading Experience For Online User Comments, Yash Prakash, Akshay Kolgar Nayak, Mohammed Shoaib Alyaan, Sampath Jayarathna, Hae-Na Lee, Vikas Ashok
Computer Science Faculty Publications
Online discussions have become integral to how people exchange ideas, form opinions, and participate in collective deliberation. While sighted users can comfortably engage with online discussions, blind users who are dependent on screen readers are forced to listen to long threads narrated in a single, monotonic voice that lacks prosodic variation, rhythm, or emotion. This robotic auditory experience not only deteriorates the user engagement with the content but also increases cognitive strain, by making it difficult to remain attentive and discern meaning beyond literal words. In an interview study, most blind participants reported that monotonous narration hindered their ability to …
Exploring Marshall–Olkin Models Through Bibliometric And Topic Modeling Approaches Uses Latent Dirichlet Allocation (1981-2025): A Study Based On Scopus Data, Humberto Llinás, Brian Llinás, Carlos López, Daniela Nuñez
Exploring Marshall–Olkin Models Through Bibliometric And Topic Modeling Approaches Uses Latent Dirichlet Allocation (1981-2025): A Study Based On Scopus Data, Humberto Llinás, Brian Llinás, Carlos López, Daniela Nuñez
Computer Science Faculty Publications
The Marshall–Olkin family of distributions has gained increasing attention in fields such as reliability engineering, survival analysis, financial risk modeling, and actuarial science because of its flexibility in modeling dependence among events and its wide range of extensions. Despite its growing relevance, a systematic understanding of how research on Marshall–Olkin models has evolved over time is still limited. This study addresses this gap by combining bibliometric techniques with topic modeling to analyze the structure and evolution of the scientific literature on Marshall–Olkin models. The analysis includes all 266 peer-reviewed publications on Marshall–Olkin models indexed in Scopus between 1981 and 2025. …
The Deregulation Of Cancer, Daniel G. Aaron
The Deregulation Of Cancer, Daniel G. Aaron
Utah Law Faculty Scholarship
Fifty years ago, the U.S. embarked on a radical new path. Under pressure from the environmental movement, Congress passed an array of statutes aimed at regulating carcinogens out of our world. This regulatory experiment sprawled from air and water to food and consumer products.
Legal scholars have paid scant attention to this wave of cancer regulation despite its size and importance and the public’s apparent interest in avoiding carcinogens. But there is a growing literature finding flaws with individual regimes within the framework, such as the Clean Air Act, the Toxic Substances Control Act, and the Tobacco Control Act. In …
The Crisis In U.S. Cancer Care: Law, Markets, And Privatization, Daniel G. Aaron
The Crisis In U.S. Cancer Care: Law, Markets, And Privatization, Daniel G. Aaron
Utah Law Faculty Scholarship
Cancer is surging among youth and young adults in the U.S., yet instead of public regulation addressing its root causes, we have outsourced the management of cancer to the private sector. A suite of laws, embodying faith that corporations will cure cancer, has subsidized the cancer biomedical enterprise and transformed quasi-public institutions into marketized, profit-seeking entities. These changes, across patent law, healthcare law, innovation law, and Food and Drug Administration (FDA) law, have privatized cancer.
The market failures I describe in U.S. cancer care raise larger questions about who we entrust with managing critical social problems. This Article provides theoretical …
Prickle4 Drives Microenvironmental Remodeling And Resistance To Parp Inhibition In Idh-Mutant Glioma, Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T Huse, Bo Chen, Timothy A Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang
Prickle4 Drives Microenvironmental Remodeling And Resistance To Parp Inhibition In Idh-Mutant Glioma, Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T Huse, Bo Chen, Timothy A Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang
Faculty, Staff and Student Publications
Mutations in isocitrate dehydrogenase (IDH) genes sensitize gliomas to PARP inhibition (PARPi) by inducing epigenetic reprogramming of DNA damage repair circuits. However, tumors treated with PARPi eventually relapse despite initial responsiveness. In this study, it is demonstrated that the anti-angiogenic agent lenvatinib synergizes effectively with PARPi, resulting in substantial tumor regression and significantly extended survival. Genomic analysis of tumors reveals that PARPi induces widespread transcriptomic changes that are predominantly pro-inflammatory, thereby promoting tumor angiogenesis. Prickle4, a planar cell polarity protein, is identified as a critical mediator of PARPi-induced neovascularization. Targeting Prickle4 effectively overcomes PARPi resistance in these tumors. Collectively, these …
Clinical And Molecular Characteristics Of Patients With Young-Onset And Average-Onset Pancreatic Adenocarcinoma, Adriana C Gamboa, Kever A Lewis, Laura R Prakash, Zhouxuan Li, Wei Qiao, Dan Zhao, Mark W Hurd, Mahmoud Yousef, Naruhiko Ikoma, Michael P Kim, Jeffrey E Lee, Jessica E Maxwell, Ching-Wei D Tzeng, Matthew H G Katz, Rebecca A Snyder
Clinical And Molecular Characteristics Of Patients With Young-Onset And Average-Onset Pancreatic Adenocarcinoma, Adriana C Gamboa, Kever A Lewis, Laura R Prakash, Zhouxuan Li, Wei Qiao, Dan Zhao, Mark W Hurd, Mahmoud Yousef, Naruhiko Ikoma, Michael P Kim, Jeffrey E Lee, Jessica E Maxwell, Ching-Wei D Tzeng, Matthew H G Katz, Rebecca A Snyder
Faculty, Staff and Student Publications
Purpose: The incidence of young-onset pancreatic cancer (YO-PC) has risen over the past two decades, yet its molecular characteristics and long-term outcomes remain poorly defined.
Methods: We retrospectively evaluated patients with PC treated at a tertiary referral center from 2016 to 2022 who had available molecular data. Patients were classified as YO-PC (≤50 years) or average-onset PC (AO-PC, >50 years). A subset analysis examined outcomes in those who underwent curative-intent pancreatectomy. Primary end points included overall survival (OS) and recurrence-free survival (RFS).
Results: Among 511 patients, 10.9% had YO-PC (n = 56; median age 44 years). Patients with YO-PC more …
Engineering Mutation Clones In Mammalian Cells With Crispr/Cas9, Zijun Huo, Jian Tu, Rachel Shoemaker, Dung-Fang Lee, Ruiying Zhao
Engineering Mutation Clones In Mammalian Cells With Crispr/Cas9, Zijun Huo, Jian Tu, Rachel Shoemaker, Dung-Fang Lee, Ruiying Zhao
Faculty, Staff and Student Publications
CRISPR, Clustered Regularly Interspaced Short Palindromic Repeat, as a powerful genome engineering system, has been widely accepted and employed in gene editing of a vast range of cell types. Compared to zinc finger nucleases (ZFNs) or transcription activator-like effector nucleases (TALENs), CRISPR shows a less complicated process and higher efficiency. With the development of different CRISPR systems, it can be used not only to knock out a gene but also to make precise modifications, activate or repress target genes with epigenetic modifications, and even for genome wide screening. Here we will describe the procedure of generating a stable cell line …
Inclusive Psychology Pedagogy Is Linked To Increased Belonging And Reduced Prejudice Toward Consensually Non-Monogamous Relationships, Rose Bern, Rachel Dinero, Kate Linenbach, Amy Moors
Inclusive Psychology Pedagogy Is Linked To Increased Belonging And Reduced Prejudice Toward Consensually Non-Monogamous Relationships, Rose Bern, Rachel Dinero, Kate Linenbach, Amy Moors
Psychology Faculty Articles and Research
Students enrolled in an elective psychology course entitled Relationship Science, which emphasized inclusive curricula focused on relationship diversity, completed pre- and postcourse assessments of attitudes toward consensually nonmonogamous (CNM) relationships, relationship skills (e.g., constructive communication), and classroom belonging. Given the established literature on lesbian, gay, bisexual, transgender, queer+-inclusive pedagogy, attitudes toward lesbian, gay, bisexual, transgender, queer+ individuals were also measured. Comparisons of pre- and postcourse assessments revealed significant reductions in stigma toward individuals engaged in CNM, alongside increased acceptance of CNM relationships more broadly. Students also reported increases in relationship skills and classroom belonging over the course of the …
When We Don’T Get Community Right In Restorative Justice Spaces: Cancel Culture And Failure To Transform, Aparna Polavarapu
When We Don’T Get Community Right In Restorative Justice Spaces: Cancel Culture And Failure To Transform, Aparna Polavarapu
Scholarly Works
This Article argues that community is a central but deeply misunderstood feature of restorative justice. Restorative justice asks us to understand harm as a break in relationship that creates obligations for the person harmed, the person who caused harm, and the community. Community is theorized to play a key role in working towards reintegration and social change, both goals of restorative justice. Yet in practice, community is often misused or underused in ways that weaken these goals. Practitioners are observing an increase in cancel culture actions by groups that claim affinity with restorative and transformative justice. However, by weaponizing the …