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Articles 21781 - 21810 of 22736
Full-Text Articles in Entire DC Network
Detection And Management Of Attacks On Synchronized Networks, Michael T. Spearman
Detection And Management Of Attacks On Synchronized Networks, Michael T. Spearman
Honors Theses and Capstones
The Precision Time Protocol (IEEE 1588) provides sub-microsecond clock synchronization across packet-switched networks and has become foundational infrastructure in 5G fronthaul, industrial control systems, and financial exchanges. Despite its criticality, most deployed PTP networks operate without active security monitoring, and no standardized detection mechanism exists for the class of attacks that deliberately stay below conventional jitter thresholds. This thesis investigates whether hardware-level ptp4l offset logs alone are sufficient to reliably detect two such attacks, slowly wandering packet delay injection and rogue master spoofing, and whether detection can occur before severe synchronization failure.
A hardware-in-the-loop testbed was constructed using two hosts …
Reading Between The Lines: Representations Of Dyslexia In Young Adult Literature, Carli B. Gauvin
Reading Between The Lines: Representations Of Dyslexia In Young Adult Literature, Carli B. Gauvin
Honors Theses and Capstones
While dyslexia affects upwards of 20% of the population, this learning disability is not commonly brought up in young adult literature. This lack of representation negatively impacts those with dyslexia, who often fail to find themselves in the books they read, and readers in general, who are given fewer opportunities to gain insight into the learning disability. Young adult books that do discuss dyslexia can be at risk of portraying the learning disability in an unfavorable light, which can make dyslexic readers feel undervalued in society and can introduce misconceptions about dyslexia to all readers. It is crucial to analyze …
Binding The Visual Experience Of Law, Nicholas Mignanelli
Binding The Visual Experience Of Law, Nicholas Mignanelli
Articles, Chapters in Books and Other Contributions to Scholarly Works
No abstract provided.
Inked Mobilities: Tattoos As Embodied Visual Narratives Of Youth Migration Between Italy And Australia, Giulia Marchetti
Inked Mobilities: Tattoos As Embodied Visual Narratives Of Youth Migration Between Italy And Australia, Giulia Marchetti
Research outputs 2022 to 2026
This article examines tattoos as embodied visual narratives within a broader study on youth transnational mobility (2019-2023). Focusing on recent Italian migration to and from Australia, 13 tattoos were documented among the 36 participants, acquired shortly before departure, during the stay in Australia, or upon return to Italy. Methodologically, the article proposes tattoo-based interviews as a participatory visual method that mobilises permanently inscribed images as sites of visual elicitation, enabling forms of reflection and storytelling. Tattoos thus operate as relational spaces of dialogue, co-interpretation, and reflexive meaning-making between researcher and participants. Epistemologically, tattoos are approached as visual narratives through which …
Employer Perspectives On Graduates’ Professional Identity Formation In The Workplace, Denise Jackson, Michael Tomlinson
Employer Perspectives On Graduates’ Professional Identity Formation In The Workplace, Denise Jackson, Michael Tomlinson
Research outputs 2022 to 2026
Professional identity (PI) is recognised as a crucial dimension in how graduates negotiate the transition to employment and move towards a pathway of sustainable professional development. Perspectives on PI have been derived mainly from higher education students with little attention given to the perspective of employers involved in supporting and supervising graduates in the workplace. Accordingly, the study surveys 339 industry professionals to examine their perceptions of how formed graduates’ PI is at different times after recruitment and the influence of personal, organisational and external factors on identity formation at work. Employers recognised how a well-formed PI enables graduates to …
Load-Settlement Behaviour Of Tailings Dam Foundation Strengthened Using The Wraparound Geosynthetic Reinforcement Technique, Francis Otieno, Sanjay Kumar Shukla
Load-Settlement Behaviour Of Tailings Dam Foundation Strengthened Using The Wraparound Geosynthetic Reinforcement Technique, Francis Otieno, Sanjay Kumar Shukla
Research outputs 2022 to 2026
This paper presents a numerical investigation of the load–settlement behaviour of a geosynthetic-reinforced tailings foundation comprised of gold tailings, subjected to the weight of a tailings dam embankment. The study considered varying conditions, including the horizontal and vertical components of the wraparound reinforcement, reinforcement burial depth, and shear strength parameters of the foundation material. A particular focus of this study is to investigate the effect of reinforcement wraparound ends on the settlement behaviour of the foundation using commercially available finite element (FE) software. The reinforcement is a single-layer biaxial woven geotextile, with and without wraparound ends, at varying depths from …
Shared Stories, Diverse Settings: A Podcast Analysis Of Stakeholder Experiences In Rural, Remote, And International Professional Experience, Marnie Harris, Narelle Lemon
Shared Stories, Diverse Settings: A Podcast Analysis Of Stakeholder Experiences In Rural, Remote, And International Professional Experience, Marnie Harris, Narelle Lemon
Research outputs 2022 to 2026
This study explores the experiences and perspectives of individuals involved in rural, remote, and international professional experience, with a particular focus on the support provided to pre-service teachers. Drawing on data generated through a series of in-depth podcast interviews, the research foregrounds the relational and contextual dimensions of teacher preparation across rural, remote, and international settings. Rural and remote communities face ongoing challenges in attracting and retaining teachers; therefore, this study explored the vital role that partnerships and supportive networks play in preparing pre-service teachers to succeed in these and other unfamiliar professional experience contexts. Through thematic analysis, the research …
When The Panic Sets In: Ai-Proofing As Pedagogical Violence In Social Work Education, Norah Hosken, Susan Bailey
When The Panic Sets In: Ai-Proofing As Pedagogical Violence In Social Work Education, Norah Hosken, Susan Bailey
Research outputs 2022 to 2026
Universities’ rushed responses to generative Artificial Intelligence (AI) constitute pedagogical violence against students and educators in social work programs. Drawing on Matusov and Sullivan’s pedagogical violence framework and Bourdieu’s symbolic violence, we examine how institutional mandates to ‘AI-proof’ assessments contradict core social work values while inflicting systematic harm. AI-proofing policies impose time-limited assessments disadvantaging disabled students and those with caring responsibilities, deploy surveillance technologies that discriminate against non-native English speakers, demand unsustainable workload increases from burned-out educators, and dismantle scaffolded pedagogy aligned with how social workers learn to practise. Using collaborative autoethnography, we document our experiences across Australian universities and …
Sheep Industry Pivot Project: Global Comparative Review, James Smith
Sheep Industry Pivot Project: Global Comparative Review, James Smith
Research outputs 2022 to 2026
Executive summary: This report forms the first stage of a two-year project led by Edith Cowan University to identify and commercialise new market pathways for Australian sheep products and by-products. The project responds to a period of significant structural change within the industry, most notably the legislated phase-out of live sheep exports by sea by May 2028, which is reshaping market dynamics and supply chain configurations. As an initial global benchmark and review, this report examines international best practice and emerging opportunities to inform industry transition, with the broader project focused on supporting producers and processors to develop and test …
Clinicians’ Experiences And Perspectives On Robot-Assisted Lower Limb And Gait Neurorehabilitation In Western Australia: Robot-Assisted Lower Limb Neurorehabilitation, Nikki Bakhtazad, Amanda Timler, Matthew K. Bagg, Rachel Buckingham, Saran Chamberlain, Barbara Singer, Patricia Martinet, Taya Hamilton, Jodie Marquez, Stuart Hodgetts, Ann Maree Vallence, Eric Gaitho, Emma Gee, Jessica Nolan
Clinicians’ Experiences And Perspectives On Robot-Assisted Lower Limb And Gait Neurorehabilitation In Western Australia: Robot-Assisted Lower Limb Neurorehabilitation, Nikki Bakhtazad, Amanda Timler, Matthew K. Bagg, Rachel Buckingham, Saran Chamberlain, Barbara Singer, Patricia Martinet, Taya Hamilton, Jodie Marquez, Stuart Hodgetts, Ann Maree Vallence, Eric Gaitho, Emma Gee, Jessica Nolan
Research outputs 2022 to 2026
Purpose: Robot-assisted lower limb rehabilitation (RALLR) may be an effective adjunct to conventional therapy for those with neurological conditions. Robot-assisted rehabilitation is emerging in Western Australia (WA) and local perspectives on this technology have not been explored. This study aimed to explore perspectives of WA clinicians on RALLR, to inform further implementation.
Methods: This was a cross-sectional survey of neurorehabilitation clinicians across metropolitan WA. A subset of respondents completed semi-structured interviews. Transcripts were analysed thematically.
Results: Fifty-six clinicians (across four professions) completed the survey. Eleven participated in an interview. The majority of clinicians expressed interest in upskilling in rehabilitation robotics …
A Proposed Conceptual Framework For Assessing Quality Of Life In The United Arab Emirates: Application To Ras Al Khaimah Emirate, Aaesha Saif Al Shehhi
A Proposed Conceptual Framework For Assessing Quality Of Life In The United Arab Emirates: Application To Ras Al Khaimah Emirate, Aaesha Saif Al Shehhi
Dissertations
Quality of Life (QoL) has become a central concern in urban planning and sustainable development, particularly in rapidly transforming contexts such as the United Arab Emirates. This dissertation proposes and empirically validates a comprehensive framework for assessing urban QoL, with a focused application to the Emirate of Ras Al Khaimah. A mixed-methods approach integrates objective indicators and residents' subjective perceptions, aligned with national strategies including UAE Vision 2030, the National Strategy for Wellbeing 2031, and UAE Centennial 2071.
The methodology combines Geographic Information Systems (GIS), the Analytic Hierarchy Process (AHP), and statistical analyses to evaluate seven key sectors: environment, infrastructure …
Uae Traditional Folklore Through Modern Media And Its Educational Potential: The Case Of Freej, Shahad Imad Mostafa
Uae Traditional Folklore Through Modern Media And Its Educational Potential: The Case Of Freej, Shahad Imad Mostafa
Theses
This mixed‑methods study examined how the Emirati animated series Freej preserves traditional folklore through vernacular language, dialect, and idiomatic expressions, and evaluated its educational potential. Guided by four questions on folklore representation, dialect/idiom use, the role of the characters, and curricular applicability, the research combined content analysis of selected episodes, interviews coding and a survey of 100 Emirati participants; survey data were summarized with descriptive statistics to triangulate qualitative insights.
Findings indicated that audiences overwhelmingly perceived Freej as linguistically and culturally authentic: 95% rated the dialect as very/somewhat authentic, 94% said it reflects elders’ speech, and 89% felt the series …
Reforma Alutsista Dan Sumber Daya Alam: Menjawab Tantangan Hukum Internasional Dan Perdamaian Dunia, Wildan Azkal Fikri, Rohadhatul Aisy
Reforma Alutsista Dan Sumber Daya Alam: Menjawab Tantangan Hukum Internasional Dan Perdamaian Dunia, Wildan Azkal Fikri, Rohadhatul Aisy
Jurnal Hukum & Pembangunan
This study departs from the paradox of the failure to achieve world peace despite the existence of an established international legal regime. It addresses three main objectives: (1) identifying the key factors that undermine world peace; (2) analyzing the failure factors of international law to realize global peace; and (3) formulating a responsive international legal architecture to future peace agendas. The study employs a critical descriptive method with a socio-legal (non-doctrinal) approach, drawing on the analytical frameworks of neorealism, great powers oligarchy, and Third World Approaches to International Law (TWAIL). The qualitative analysis is conducted by examining power relations, the …
Tinjauan Frasa “Setiap Orang” Dalam Pasal 3 Ayat (1) Peraturan Pemerintah Nomor 56 Tahun 2021 Tentang Pengelolaan Royalti Hak Cipta Lagu Dan/Atau Musik, Fajar Hidayansyah Ilham, Luna Dezeana Ticoalu
Tinjauan Frasa “Setiap Orang” Dalam Pasal 3 Ayat (1) Peraturan Pemerintah Nomor 56 Tahun 2021 Tentang Pengelolaan Royalti Hak Cipta Lagu Dan/Atau Musik, Fajar Hidayansyah Ilham, Luna Dezeana Ticoalu
Jurnal Hukum & Pembangunan
Copyright is one form of legal protection for intellectual works, occupying an important position within the intellectual property law system. The Copyright Law explicitly grants exclusive rights to creators, encompassing both moral rights and economic rights. Economic rights, as stipulated in Article 9 paragraph (1), allow creators to obtain economic benefits from their works, ranging from publication, reproduction, distribution, performance, to communication to the public. This provision shows that creators hold a primary position as legal subjects entitled to protection, while also serving as central actors in the creative industry ecosystem. In practice, the mechanism for copyright protection requires implementing …
The Nlrb’S Authority To Make Workers Whole, Wanny Mei
The Nlrb’S Authority To Make Workers Whole, Wanny Mei
Fordham Law Review
In December 2022, the National Labor Relations Board (NLRB or the “Board”) announced a modified make-whole remedial framework in Thryv, Inc.For all standard make-whole relief orders, the Board would order relief for direct or foreseeable pecuniary harms that employees suffer as a result of an unfair labor practice. Proponents of this remedial design assert that this is consistent with the Board’s authority under section 10(c) of the National Labor Relations Act (NLRA). On the other hand, opponents find that this design exceeds the Board’s statutory authority and conflicts with the Seventh Amendment right to a jury trial.
This Note …
Recalibrating Deference In Sentencing, Meghana Nemali
Recalibrating Deference In Sentencing, Meghana Nemali
Fordham Law Review
The U.S. Sentencing Commission (the “Commission”) is responsible for promoting consistency, transparency, and fairness in federal sentencing. In pursuit of this mandate, the Commission publishes the U.S. Sentencing Guidelines (the “Guidelines”), which are accompanied by official commentary. In Stinson v. United States, the U.S. Supreme Court endowed the commentary with controlling authority. However, nearly three decades later, the Court in Kisor v. Wilkie granted courts greater discretion in deciding whether to defer to the commentary. Moreover, in 2024, the Court eliminated the absolute deference regime for administrative agency determinations in Loper Bright Enterprises v. Raimondo. As a result, …
Clean Hands, Dirty Money, And The Codification Of Sec Disgorgement, Stephanie Palma
Clean Hands, Dirty Money, And The Codification Of Sec Disgorgement, Stephanie Palma
Fordham Law Review
Disgorgement is the U.S. Securities and Exchange Commission’s (SEC) most powerful enforcement tool and among its most controversial. For decades, federal courts treated disgorgement in securities enforcement actions as an equitable remedy, a view that the U.S. Supreme Court confirmed in Liu v. SEC. Months after Liu, Congress passed the William M. (Mac) Thornberry National Defense Authorization Act for Fiscal Year 2021, which codified disgorgement in SEC enforcement actions. The codification of disgorgement sparked a circuit split between the U.S. Courts of Appeals for the Fifth and Second Circuits over whether Congress created a new statutory form of …
Remote Access Restrictions To Immigration-Related Court Records, Doris H. Zhang
Remote Access Restrictions To Immigration-Related Court Records, Doris H. Zhang
Fordham Law Review
Journalists today often report on newsworthy federal court cases by remotely accessing the court records online. However, thanks to Federal Rule of Civil Procedure 5.2(c), remote access is not available by default in immigration-related cases. To obtain any court records in immigration cases, journalists must go to the courthouse, hire someone to go on their behalf, or ask the court to exercise its discretion to lift the Rule 5.2(c) remote access restrictions. These alternatives are burdensome, hindering the ability of the press and the public to keep track of immigration cases in federal courts. Despite the burdens on the press …
Advancing Treatment Of Pleural Infection, Estee Pui Mun Lau
Advancing Treatment Of Pleural Infection, Estee Pui Mun Lau
Theses: Doctorates and Masters
Introduction: Pleural infection remains a major clinical concern, with an increasing incidence worldwide. The use of intrapleural tissue plasminogen activator (tPA) with deoxyribonuclease (DNase) therapy represents a major breakthrough as it offers an effective alternative to surgery for patients who fail conventional treatment. However, the optimal dosage of tPA is yet to be established. Indwelling pleural catheter (IPC)-related infections, especially IPC-related pleural infections are a significant concern and a barrier to the uptake of IPC. The development of a long-term preventative strategy is imperative to promote uptake and improve the quality of life of patients, particularly in those who have …
Kedudukan Hukum Eks-Kreditor Pasca Debt To Equity Swap Yang Dihomologasi Dalam Pkpu Kedua Dan Kepailitan Debitor Akibat Pembatalan Perdamaian, Reza Rahmawati
Kedudukan Hukum Eks-Kreditor Pasca Debt To Equity Swap Yang Dihomologasi Dalam Pkpu Kedua Dan Kepailitan Debitor Akibat Pembatalan Perdamaian, Reza Rahmawati
Jurnal Hukum & Pembangunan
Debt to Equity Swap (DES) under a composition plan in Suspension of Debt Payment Obligations (PKPU) proceedings constitutes a restructuring mechanism that transforms the legal status of a Creditor into that of a shareholder upon homologation. Legal issues arise when The Debtor subsequently enters a Second PKPU due to newly incurred debts or is declared bankrupt following the annulment of the composition, while Law No. 37 of 2004 on Bankruptcy and Suspension of Debt Payment does not expressly regulate the legal consequences of a DES under such circumstances. This normative legal research aims to analyze the legal standing and legal …
Omnibus Law Sebagai Strategi Mengatasi Disharmonisasi Peraturan Di Indonesia, Tuti Tri Hastuti S., Zainal Arifin Hoessein
Omnibus Law Sebagai Strategi Mengatasi Disharmonisasi Peraturan Di Indonesia, Tuti Tri Hastuti S., Zainal Arifin Hoessein
Jurnal Hukum & Pembangunan
This article discusses the challenges in implementing the Omnibus Law (OL) both as a regulatory system and as a tool for harmonizing regulations within Indonesia’s legal positivist tradition and its complex, non-simple regulatory hierarchy, from the perspectives of legislative consolidation theory, regulatory coherence theory, and multilevel regulation theory. This study is based on the assumption that OL, within the framework of legal positivism (norm hierarchy system), faces problems in applying these three theories. The research employs normative juridical and comparative methods, analyzing national regulations and international research findings. The results indicate, first, that the positioning of OL, which does not …
Constraining Citizenship: Presidential Threshold In Indonesia’S Judicial Framework, Arfan Yanayir Akbar Sabillilah
Constraining Citizenship: Presidential Threshold In Indonesia’S Judicial Framework, Arfan Yanayir Akbar Sabillilah
Jurnal Hukum & Pembangunan
This research critically evaluates the constitutionality of Indonesia's Presidential Threshold as regulated by Article 222 of Law No. 7/2017, requiring political parties or coalitions to secure 20% of DPR seats or 25% of national valid votes for presidential nominations. The term “Presidential Threshold” follows Constitutional Court jurisprudence, distinguishing it from the election threshold in Article 6A(3) requiring 50%+1 votes to win the presidency and the parliamentary threshold in Article 414 requiring 4% of votes for legislative seat allocation. Through normative legal analysis of Constitutional Court decisions No. 51-52-59/PUU-VI/2008, 53/PUU-XV/2017, and 62/PUU-XXII/2024, this study examines 33 judicial reviews from 2017 to …
Kedudukan Putusan Peradilan Etik Sebagai Keputusan Tata Usaha Negara: Studi Kasus Gugatan Hakim Konstitusi Anwar Usman, Satrio Febriyanto
Kedudukan Putusan Peradilan Etik Sebagai Keputusan Tata Usaha Negara: Studi Kasus Gugatan Hakim Konstitusi Anwar Usman, Satrio Febriyanto
Jurnal Hukum & Pembangunan
As an effort to concretize ethics, there is a process of formalizing ethics into a set of rules through a code of ethics. The code of ethics needs institutional enforcement instruments so that it can be effectively applied through ethical trials. Ethical courts, as institutions that adjudicate violations of the code of ethics, have the authority to issue decisions as a follow-up to cases of violations of the code of ethics that they handle. In carrying out its duties, ethical courts use ethical and moral analysis to assess the appropriateness of an action. This analytical approach differs from legal decisions …
Global Manta And Devil Ray Population Declines: Closing Policy And Management Gaps To Reduce Fisheries Mortality, Betty J.L. Laglbauer, Nidhi G. D'Costa, Joshua D. Stewart, Marta D. Palacios, Melissa Cronin, Daniel Fernando, Nerea Lezama-Ochoa, Asia O. Armstrong, Rima W. Jabado, Sarah Fowler, Julia M. Lawson, Olga Koubrak, Jefferson Murua, Thanda Ko Gyi, Divya Karnad, Mayuri Chopra, Giuseppe Notarbartolo-Di-Sciara, Joshua Rambahiniarison, Don Croll, Stefany Rojas, Abdulaziz Fahmi, Joanna L. Harris, Alifa Binthe Haque, Hilario Murua, Juan Carlos Pérez-Jiménez, Emily Humble, Ellen Barrowclift, Muhammad G. Salim, Godefroy De Bruyne, Issah Seidu
Global Manta And Devil Ray Population Declines: Closing Policy And Management Gaps To Reduce Fisheries Mortality, Betty J.L. Laglbauer, Nidhi G. D'Costa, Joshua D. Stewart, Marta D. Palacios, Melissa Cronin, Daniel Fernando, Nerea Lezama-Ochoa, Asia O. Armstrong, Rima W. Jabado, Sarah Fowler, Julia M. Lawson, Olga Koubrak, Jefferson Murua, Thanda Ko Gyi, Divya Karnad, Mayuri Chopra, Giuseppe Notarbartolo-Di-Sciara, Joshua Rambahiniarison, Don Croll, Stefany Rojas, Abdulaziz Fahmi, Joanna L. Harris, Alifa Binthe Haque, Hilario Murua, Juan Carlos Pérez-Jiménez, Emily Humble, Ellen Barrowclift, Muhammad G. Salim, Godefroy De Bruyne, Issah Seidu
School of Biological and Marine Sciences
Significant progress has been made in advancing priority actions to conserve manta and devil rays, yet implementation and enforcement of protective measures often fall short, leaving most mobulid populations at risk of overfishing. Drawing on a literature review, fisheries databases, agency reports, and expert interviews, we assess global trends in mobulid catch and mortality. We examine both targeted and incidental catch, in small (<15 m, ‘SV’) and large (>15 m, ‘LV’) vessel fisheries to identify hotspots with the highest risk of fisheries-related mortality and population decline. We estimate global fisheries catch at 264,520 (184,407–344,987) mobulids per year, with SV fisheries accounting for 87 % …15>
Investigating Spatial And Seasonal Differences In Microgastropod Assemblages Within The Little-Studied Camamu Bay, Brazil: A Potential Bioindicator For Remote Tropical Areas?, Francisco Kelmo, Sol De Maria Cesar Ferreira, Eduardo Henrique Galvão, Martin J. Attrill
Investigating Spatial And Seasonal Differences In Microgastropod Assemblages Within The Little-Studied Camamu Bay, Brazil: A Potential Bioindicator For Remote Tropical Areas?, Francisco Kelmo, Sol De Maria Cesar Ferreira, Eduardo Henrique Galvão, Martin J. Attrill
School of Biological and Marine Sciences
This study investigates spatial and seasonal variation in the assemblages of benthic microgastropods (snails < 5–10 mm in length) within a poorly studied tropical bay. As these organisms are abundant, diverse and relatively easy to sample, with well-established taxonomy, they may prove a highly suitable group for ecological studies in such areas. Sediment samples were collected from three river basins in Camamu Bay, Brazil, during the wet and dry seasons. A total of 132 microgastropod species was recorded, demonstrating high diversity. The most abundant species were Eulithidium affine, Bittiolum varium, Cerithium atratum, Vitta virginea and Schwartziella bryerea. The least abundant species were Tenaturris gemma, Turbinella laevigata, Petaloconchus erectus, Parviturboides interruptus and Vitrinella cupidinensis. Statistical analysis revealed significant seasonal and spatial differences in diversity and assemblage composition, which correlated with environmental gradients. The results suggest that microgastropods are a suitable component of the biota for ecological and applied studies in marine sediments, particularly in remote tropical locations where full macrofaunal analysis may be challenging. Whilst further testing across impact gradients is needed, this approach offers a practical solution for ecological investigations in remote regions with limited taxonomic expertise and highlights microgastropods as a useful indicator taxon for impact biomonitoring in tropical marine sediments.
Evolving Molecular Subtypes Of Gastric Cancer: From Past Classifications To Present Consensus And Future Directions For Precision Therapy, Ju-Seog Lee
Faculty, Staff and Student Publications
Gastric cancer is a biologically heterogeneous disease. The advent of high-throughput multi-omic technologies has revolutionized our understanding of gastric cancer by deconstructing this heterogeneous entity into distinct and more homogeneous molecular subtypes. Early classifications based on gene expression, methylation, and histology have laid the groundwork for multi-omic frameworks proposed by The Cancer Genome Atlas and Asian Cancer Research Group, which established the foundation of modern molecular taxonomy. Subsequent integrative efforts, particularly the Consensus Genomic Subtypes (Super 6) model, have unified this collected information into clinically relevant subtypes that bridge prognostic stratification with treatment strategies. Established biomarkers such as human epidermal …
Nsd2 Inhibitors Rewire Chromatin To Treat Lung And Pancreatic Cancers, Jinho Jeong, Simone Hausmann, Hanyang Dong, Kacper Szczepski, Natasha M Flores, Andy Garcia Gonzalez, Liyang Shi, Xiaoyin Lu, Joanna Lempiäinen, Moritz Jakab, Liyong Zeng, Tourkian Chasan, Eric Bareke, Rui Dong, Emma Carlson, Reinnier Padilla, Dylan Husmann, Julia Thompson, Gerry A Shipman, Emily Zahn, Courtney A Barnes, Laiba F Khan, Liz Marie Albertorio-Sáez, Eva Brill, Vishnu Udayakumar Sunita Kumary, Matthew R Marunde, Danielle N Maryanski, Cheryl C Szany, Bryan J Venters, Carolina Lin Windham, Michal Eligiusz Nowakowski, Iwona Czaban, Mariusz Jaremko, Michael-Christopher Keogh, Kang Le, Michael J Soth, Benjamin A Garcia, Łukasz Jaremko, Jacek Majewski, Pawel K Mazur, Or Gozani
Nsd2 Inhibitors Rewire Chromatin To Treat Lung And Pancreatic Cancers, Jinho Jeong, Simone Hausmann, Hanyang Dong, Kacper Szczepski, Natasha M Flores, Andy Garcia Gonzalez, Liyang Shi, Xiaoyin Lu, Joanna Lempiäinen, Moritz Jakab, Liyong Zeng, Tourkian Chasan, Eric Bareke, Rui Dong, Emma Carlson, Reinnier Padilla, Dylan Husmann, Julia Thompson, Gerry A Shipman, Emily Zahn, Courtney A Barnes, Laiba F Khan, Liz Marie Albertorio-Sáez, Eva Brill, Vishnu Udayakumar Sunita Kumary, Matthew R Marunde, Danielle N Maryanski, Cheryl C Szany, Bryan J Venters, Carolina Lin Windham, Michal Eligiusz Nowakowski, Iwona Czaban, Mariusz Jaremko, Michael-Christopher Keogh, Kang Le, Michael J Soth, Benjamin A Garcia, Łukasz Jaremko, Jacek Majewski, Pawel K Mazur, Or Gozani
Faculty, Staff and Student Publications
NSD2 catalyses the epigenetic modification H3K36me2 (refs. 1,2) and is a candidate convergent downstream effector of oncogenic signalling in diverse malignancies3–5. However, it remains unclear whether the enzymatic activity of NSD2 is therapeutically targetable. Here we characterize a series of clinical-grade small-molecule catalytic NSD2 inhibitors (NSD2i) and show that the pharmacological targeting of NSD2 constitutes an epigenetic dependency with broad therapeutic efficacy in KRAS-driven preclinical cancer models. NSD2i inhibits NSD2 with single-digit nanomolar half-maximal inhibitory concentration potency and high selectivity over related methyltransferases. Structural analyses reveal that the specificity of NSD2i for NSD2 …
Grading Melanocytic Dysplasia: Updated Histopathologic Criteria, Christopher R Shea, Victor G Prieto, Catherine M Shachaf, Scott R Florell
Grading Melanocytic Dysplasia: Updated Histopathologic Criteria, Christopher R Shea, Victor G Prieto, Catherine M Shachaf, Scott R Florell
Faculty, Staff and Student Publications
Dr. Martin C. Mihm, Jr.'s innovative work on the dysplastic nevus achieved a milestone in his chapter in the World Health Organisation Classification of Skin Tumours (WHO-C). WHO-C presents a dichotomous classification (high-grade versus low-grade dysplastic nevi) and a quantitative metric to assess melanocytic nuclear enlargement. The Duke classification is a related approach that provides mostly quantitative histopathologic criteria for dysplastic nevi and gives due weight to architectural features as well as cytology. This paper proposes and illustrates updated criteria for scoring and grading melanocytic dysplasia, incorporating some of the definitions and categories of WHO-C, while refining the quantitative and …
Review Of 'The Royal Musical Association: Creating Scholars, Advancing Research' By Leanne Langley, Nuria Bonet
Review Of 'The Royal Musical Association: Creating Scholars, Advancing Research' By Leanne Langley, Nuria Bonet
School of Art, Design and Architecture
No abstract provided.
Planetarity And Relation: Ecology As Method, Ashish Ghadiali
Planetarity And Relation: Ecology As Method, Ashish Ghadiali
School of Art, Design and Architecture Theses
The List of Works submitted comprises research through film, text, exhibition, performance and policy engagement, developed during a three-year period from 2021 to 2024 in the site-specific location of Southwest England. This multi-modal and interdisciplinary practice is framed in response to the question of how art and cultural strategy can, in the contexts of climate breakdown and global racial inequity, be conceived of as agency for environmental justice. In this integrative summary, I present a theoretical framework where ecology, in response to conditions of environmental crisis, is understood not only as a subject of inquiry but also as method. In …