Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network

Open Access. Powered by Scholars. Published by Universities.®

2026

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 18691 - 18720 of 18721

Full-Text Articles in Entire DC Network

Richmond Electronic Monitoring: The City Sees You While You're Sleeping, Fakira D. Johnson Jan 2026

Richmond Electronic Monitoring: The City Sees You While You're Sleeping, Fakira D. Johnson

Law Student Publications

The United States has increasingly recognized its reputation as a prison state, with widespread acknowledgment of its high incarceration rates. As of 2021, the United States imprisoned one out of every five prisoners in the world. Additionally, of its own population, the United States imprisoned one out of every one hundred people.

In response to this notoriety, worsening prison overcrowding, and the heightened risks posed by the COVID-19 pandemic, all fifty states, the District of Columbia, and the federal government increased their utilization of alternative measures to traditional incarceration. As both an addition and an alternative to traditional incarceration, criminal …


Developing Empathy In Business Students Through Humanities-Based Study Abroad: An Exploratory Empirical Study, Jorge Colazo, Makiko Fukuda, Katsuo Nishikawa Chávez Jan 2026

Developing Empathy In Business Students Through Humanities-Based Study Abroad: An Exploratory Empirical Study, Jorge Colazo, Makiko Fukuda, Katsuo Nishikawa Chávez

School of Business Faculty Research

No abstract provided.


Nanoparticle Albumin-Bound Paclitaxel And Nivolumab For Pd-1 Inhibitor-Refractory Recurrent Or Metastatic Head And Neck Squamous-Cell Carcinoma, Douglas Adkins, Jessica C Ley, Christine Auberle, Brendan Knapp, Jesse Zaretsky, Jingxia Liu, Peter Oppelt Jan 2026

Nanoparticle Albumin-Bound Paclitaxel And Nivolumab For Pd-1 Inhibitor-Refractory Recurrent Or Metastatic Head And Neck Squamous-Cell Carcinoma, Douglas Adkins, Jessica C Ley, Christine Auberle, Brendan Knapp, Jesse Zaretsky, Jingxia Liu, Peter Oppelt

2020-Current year OA Pubs

INTRODUCTION: Standard therapy for PD-1 inhibitor-refractory recurrent or metastatic head and neck squamous-cell carcinoma (RM-HNSCC) has limited activity. Drugs bound to albumin selectively target cancer cells with upregulated macropinocytosis, a process driven by constitutively hyper-activated EGFR/RAS/PIK3CA signaling, which is common in HNSCC. Nanoparticle albumin-bound (nab)-paclitaxel is active in PD-1 inhibitor-naïve RM-HNSCC and alters immune cells to potentially prime tumor response and reverse resistance to PD-1 inhibitors.

METHODS: In a single-arm phase 2 trial, patients with PD-1 inhibitor-refractory RM-HNSCC received nab-paclitaxel and nivolumab given in 28-day cycles. The primary endpoint was objective response rate (ORR), using RECIST1.1. Key secondary endpoints were …


International Cocoa Trading Arrangements Between Industrialised And Developing Countries 1951–1999: A Structural Gravity Analysis, John Brown, Xenia Matschke, Juan René Rojas Rodríguez Jan 2026

International Cocoa Trading Arrangements Between Industrialised And Developing Countries 1951–1999: A Structural Gravity Analysis, John Brown, Xenia Matschke, Juan René Rojas Rodríguez

Economics

Using a state-of-the-art structural gravity model, we investigate the impact of various (post-)colonial cocoa trading arrangements on the cocoa trade between developing cocoa producer countries and rich industrial cocoa consumer nations in the time period 1951–1999. We find that in particular the trading arrangements of the European (Economic) Community (EEC/EC), such as the Association, Yaoundé and Lomé Agreements, as well as the UNCTAD International Cocoa Agreement, had a measurable positive impact on cocoa trade flows, in contrast to the British Commonwealth partnership or the GATT Generalised System of Preferences. In particular, the Yaoundé Agreement not only increased the trade between …


An Integrated Framework For Last-Mile Delivery Optimization Using Reinforcement Learning And Social Media-Based Traffic Prediction In Underdeveloped Megacities, Vasanth Bhat Jan 2026

An Integrated Framework For Last-Mile Delivery Optimization Using Reinforcement Learning And Social Media-Based Traffic Prediction In Underdeveloped Megacities, Vasanth Bhat

Graduate Studies Theses and Dissertations 2026

Supply chain management has become increasingly critical as transportation costs rise and urban delivery systems place additional pressure on already congested networks. Last-mile delivery—the movement of goods from distribution centers to end users—represents the most expensive and operationally complex segment of the logistics process, particularly in underdeveloped megacities characterized by unpredictable traffic, limited infrastructure, and sparse real-time data. This dissertation proposes an integrated framework for optimizing last-mile delivery in such environments by combining social media–based traffic intelligence, machine learning, and deep reinforcement learning. The framework leverages unstructured, real-time data from social media platforms to enhance traffic prediction and incorporates these …


Do Fair Schedules Matter? Work-Home Conflict And Justice In Emergency Medicine, Maresca J. Brand Jan 2026

Do Fair Schedules Matter? Work-Home Conflict And Justice In Emergency Medicine, Maresca J. Brand

Graduate Studies Theses and Dissertations 2026

Emergency physicians work in a high-demand environment requiring irregular, around-the-clock schedules, which can contribute to elevated work-home conflict and burnout. While previous research has focused on objective schedule characteristics such as length of shift or time of day worked, less attention has been given to how emergency physicians perceive the fairness of the scheduling process itself. Drawing on Work-Home Resources Theory and Personal Resource Allocation Theory, this study examines whether perceptions of schedule justice influence work-home conflict via schedule satisfaction. I propose that perceived fairness in schedule creation functions as a contextual resource that shapes whether a schedule is experienced …


Adequate Representation In Group Litigation, Elizabeth Chamblee Burch Jan 2026

Adequate Representation In Group Litigation, Elizabeth Chamblee Burch

Scholarly Works

This article examines the inherent tension between the legal system's desire for "global peace" (finality) and the constitutional requirement for adequate representation in collective lawsuits. While Rule 23 class actions provide structural safeguards—such as judicial oversight of counsel and settlement, and opt-out rights—alternative mechanisms like multidistrict litigation (MDL) and parens patriae suits often lack these protections . Using the In re National Prescription Opiate Litigation as a primary case study, the article illustrates how informal, "backroom" leadership selection in MDLs empowers a small circle of elite "repeat players" at the expense of marginalized groups, such as Native American tribes and …


Taxing Ai, Assaf Harpaz Jan 2026

Taxing Ai, Assaf Harpaz

Scholarly Works

Artificial intelligence (AI) is poised to transform the distribution and sources of income, with some experts predicting widespread job displacement. Even under optimistic projections, AI is expected to exacerbate wealth inequality, given that the technology’s ownership and immense value are concentrated within a subset of Big Tech companies and AI startups. These outcomes will have far-reaching impacts on the federal tax system, which heavily relies on taxing individual labor income and payroll, rather than capital or consumption.

This Article argues that AI threatens to disrupt the tax system’s ability to fulfill its fundamental goals of raising revenue, redistributing income, and …


From Privacy To The Data Economy: The Ftc’S Reframing Of Its Regulatory Priorities, Maria P. Angel Jan 2026

From Privacy To The Data Economy: The Ftc’S Reframing Of Its Regulatory Priorities, Maria P. Angel

Scholarly Works

This Article argues that the Federal Trade Commission’s turn to “commercial surveillance” reflects a strategic shift away from traditional privacy frameworks toward addressing structural power dynamics in the data economy. Drawing on an analysis of 112 FTC documents, it identifies three core commitments: tackling systemic harms, adopting a political economy lens, and constraining corporate power. The Article contends that this reframing is both necessary in the AI age and should influence the future of privacy regulation in the United States, even amid efforts to limit the FTC’s authority.


Qui Tam Legislation And Article Ii: State Constitutional Precursors To The “Take Care” Clause, Randy Beck Jan 2026

Qui Tam Legislation And Article Ii: State Constitutional Precursors To The “Take Care” Clause, Randy Beck

Scholarly Works

Anglo-American legislation since the fourteenth century has often authorized “popular” or “qui tam” enforcement, in which an uninjured “common informer” litigates to collect a forfeiture for violation of a statute. Popular enforcement has become considerably less common than in earlier centuries, but remains important because of the qui tam provisions of the federal False Claims Act (FCA). In Vermont Agency of Natural Resources v. United States ex rel. Stevens, the Supreme Court rejected an Article III standing challenge to qui tam litigation, concluding that the long history of popular enforcement means qui tam suits present cognizable “cases and controversies of …


Abandoning Press Freedom, Ronnell Andersen Jones, Sonja R. West Jan 2026

Abandoning Press Freedom, Ronnell Andersen Jones, Sonja R. West

Scholarly Works

Among elected officials and the broader public, attitudes toward the press are deeply polarized along ideological lines. Polling shows that most liberals favor the press, while conservatives view it more negatively— a partisan divide that has widened significantly over the past decade. Conventional wisdom suggests that the same ideological split is also at work at the Supreme Court, with liberal Justices championing the work of the press while their conservative colleagues express more skepticism. This perception is reinforced by historical examples of liberal Justices advancing press rights alongside broader democracy-engagement and social-justice issues. Recent calls from some conservative Justices to …


Digital Reuse And Online Availability Of Visual Artworks, Paul J. Heald, Matthias Sahli, Alexander Cuntz Jan 2026

Digital Reuse And Online Availability Of Visual Artworks, Paul J. Heald, Matthias Sahli, Alexander Cuntz

Scholarly Works

We study how copyright impacts the distribution and reuse of images in the visual arts sector, exploiting the discontinuity at the 1926 US public domain cutoff together with cross-country variation between US and European museums. We find that public domain status raises artist-level image availability on Useum, a major image aggregator, by approximately 19 percent relative to comparable copyrighted artworks. Onward reuse of Useum images across the web is substantial - an artwork image appears on 76 additional web pages on average - and is higher for public domain artworks, though estimates are statistically significant only in some specifications. Moreover, …


Gienapp's Big Book: Conceptual Rupture, Modernism, And The End Of Originalism, Logan E. Sawyer Iii Jan 2026

Gienapp's Big Book: Conceptual Rupture, Modernism, And The End Of Originalism, Logan E. Sawyer Iii

Scholarly Works

For decades, we have lived in an age of partisan jurisprudence, in which nearly every Republican has embraced originalism, and nearly every Democrat has rejected it. One can mark the start of that era in multiple places, but one good choice is November 11th, 1977. That day, in the pages of National Review, William F. Buckley previewed Government by Judiciary, Raoul Berger’s originalist critique of the Warren Court’s rights revolution. The review, entitled “Berger’s Big Book,” was highly complimentary. Berger’s rebuke of Warren Court activism was, Buckley thought, “devastating.” And he was not alone. Following the publication of Government by …


State Medical Licenses Without Borders, Meighan Parker Jan 2026

State Medical Licenses Without Borders, Meighan Parker

Scholarly Works

Access to health care in the United States is undermined by a maldistribution of physicians, and state medical licensure remains a barrier to correcting this issue, despite legal reforms that attempt to streamline physician licensure pathways. Geographic distribution gaps can have serious consequences in rural areas, such as poor health outcomes, reduced access to care, and further entrenchment of health disparities.

On the bright side, physicians can potentially use telemedicine to help improve geographic distribution gaps through the provision of clinically appropriate, virtual care across state lines. But states have traditionally required physicians, even those who are currently licensed in …


Voltage Stability Enhancement Of Large Load Interconnections Using Syncronous Condensers, Muhammad Ibrahim Abbas Jan 2026

Voltage Stability Enhancement Of Large Load Interconnections Using Syncronous Condensers, Muhammad Ibrahim Abbas

Graduate Studies Theses and Dissertations 2026

The rapid integration of hyperscale data centers as large, concentrated loads presents a growing voltage stability challenge in grids weakened by synchronous generator retirement and increasing inverter-based resource penetration. This work proposes a Jacobian-based sensitivity framework for systematically identifying voltage-critical buses and optimally siting synchronous condensers as voltage support resources. A voltage-weighted sensitivity index, extracted from the full Jacobian inverse, is introduced to combine network-wide reactive coupling strength with observed voltage drops into a single deployable placement criterion. Validation on IEEE 14-bus and 30-bus test systems under multiple loading scenarios demonstrates that the proposed criterion consistently identifies the correct placement …


Pseudo-Boiling Of Supercritical Co2 In A Parallel-Flow Microchannel And A Micro-Jets Impingement Device And Single-Phase And Two-Phase Heat Transfer Of Subcritical Co2 Jets, Pranzal Ahmed Jan 2026

Pseudo-Boiling Of Supercritical Co2 In A Parallel-Flow Microchannel And A Micro-Jets Impingement Device And Single-Phase And Two-Phase Heat Transfer Of Subcritical Co2 Jets, Pranzal Ahmed

Graduate Studies Theses and Dissertations 2026

Carbon dioxide (CO2) is gaining attention as a low-toxicity, zero-ozone-depletion refrigerant with a global warming potential of 1, making it an attractive alternative to synthetic HFCs/HFOs. Near its critical point, CO2's thermophysical properties change sharply with small shifts in temperature and pressure — a behavior that can be exploited to enhance heat transfer in trans-critical power cycles and electronics cooling. This dissertation experimentally investigates heat transfer during the pseudo-boiling of supercritical CO2 in a parallel-flow microchannel and a micro-jet impingement device, alongside CO2 flow boiling and single-phase water heat transfer in micro-jet impingement. Using microfluidic devices instrumented with embedded resistance …


Effects Of Back-Pressure On Pseudo-Shock Systems, Emil C. Alunno Jan 2026

Effects Of Back-Pressure On Pseudo-Shock Systems, Emil C. Alunno

Graduate Studies Theses and Dissertations 2026

The isolator of a scramjet engine houses a pseudo-shock, a compressive flow structure that raises the static pressure and decelerates the incoming supersonic flow for efficient combustion while shielding the inlet from the elevated pressure downstream. Under sufficient back pressure the leading shock bifurcates and forms a shock train followed by a shockless mixing region, and the resulting system oscillates even under nominally steady conditions; this unsteadiness distorts the flow, can drive the pseudo-shock out of the isolator and unstart the inlet. This thesis experimentally examines how a pseudo-shock in a constant-area isolator at a measured entrance Mach number of …


Did They Think I Was Rude? The Emotional And Relational Consequences Of (In)Congruence Between Perpetrators’ Self- And Meta-Perceptions Of Workplace Rudeness, Nicholas C. Andriese Jan 2026

Did They Think I Was Rude? The Emotional And Relational Consequences Of (In)Congruence Between Perpetrators’ Self- And Meta-Perceptions Of Workplace Rudeness, Nicholas C. Andriese

Graduate Studies Theses and Dissertations 2026

Workplace rudeness negatively impacts employees and costs organizations millions of dollars each year. Although much is known about the consequences of workplace rudeness, little is known about how perpetrators make sense of and respond to their (potentially) rude behavior. In this dissertation, I propose that perpetrators consider not only their self-perceptions of rudeness, or how rude they believe their actions were, but also their meta-perceptions of rudeness, or their beliefs about how rude another person perceived them to be. Because rudeness is subjective and people vary in their perceptual accuracy, self- and meta-perceptions of rudeness are unlikely to consistently …


Numerical Investigation Of Reacting Flow In Pmma-Fueled Solid Fuel Scramjet Combustors Under Experimental Test Conditions, Hunter Bassett Jan 2026

Numerical Investigation Of Reacting Flow In Pmma-Fueled Solid Fuel Scramjet Combustors Under Experimental Test Conditions, Hunter Bassett

Graduate Studies Theses and Dissertations 2026

A simplified steady RANS-based numerical study of reacting flow in solid-fuel scramjet combustors is presented to evaluate the ability of commercial CFD frameworks to reproduce key features observed in experimental test sections. The work focuses on solid PMMA fuel in two supersonic combustor configurations: a cavity-assisted flameholding combustor and a variable-angle diverging combustor. The cavity combustor is analyzed as a baseline case and results are compared directly with experimental data. Three combustor geometry states corresponding to ignition, early-burning, and steady-burning conditions are investigated. Meshes are assessed through a systematic grid refinement method to establish grid independence. A novel variable-angle diverging …


Fgf19 As A Colorectal Cancer Serum Biomarker And Fgfr4 As A Mediator Of Anti-Her2 Resistance In Breast Cancer, Jordan Beardsley Jan 2026

Fgf19 As A Colorectal Cancer Serum Biomarker And Fgfr4 As A Mediator Of Anti-Her2 Resistance In Breast Cancer, Jordan Beardsley

Graduate Studies Theses and Dissertations 2026

The fibroblast growth factor 19 (FGF19)-fibroblast growth factor receptor 4 (FGFR4) signaling pathway regulates hepatic metabolism, bile acid (BA) synthesis, and hepatocyte proliferation. This signaling axis also is implicated in promoting tumor progression, therapeutic resistance, and metastasis in certain cancers.

In colorectal cancer (CRC) there is a critical need for non-invasive biomarkers for disease detection and monitoring. We identified FGF19 as a candidate CRC serum marker through meta-transcriptomics and found FGF19 to be expressed and secreted by CRC cell lines. Tumor-derived FGF19 was detectable in mouse serum at levels correlating with tumor volume in a subcutaneous xenograft model. RNA sequencing …


An Exploration Of The Professionalization Of Graduate Students Using Rhetorical Theory, Jennifer M. Crowell Jan 2026

An Exploration Of The Professionalization Of Graduate Students Using Rhetorical Theory, Jennifer M. Crowell

Graduate Studies Theses and Dissertations 2026

This qualitative study examines the professionalization of graduate students as a rhetorically mediated and relational process of identity development within an interdisciplinary doctoral program. While existing scholarship emphasizes institutional structures and formal mechanisms of professional preparation, less attention has been given to how graduate students experience professionalization at the individual level. This study addresses that gap by exploring how students interpret expectations, use rhetorical strategies, and construct professional identities across multiple disciplinary contexts.

Grounded in organizational rhetoric and community of practice theory, the study investigates how graduate students in the Texts & Technology Ph.D. Program at the University of Central …


A Case Study Examining Organizational Influences On Student Teacher Placement In K-12 Classrooms, Rachel L. Ickes Jan 2026

A Case Study Examining Organizational Influences On Student Teacher Placement In K-12 Classrooms, Rachel L. Ickes

Graduate Studies Theses and Dissertations 2026

Student teaching is a prominent and required learning experience in most teacher education programs. The learning that takes place in student teaching blends pedagogy with practice. However, not all student teaching placements provide positive learning experiences for student teachers. This descriptive case study examines the organizational factors that affect the process of student teacher placement at K-12 classroom sites by one teacher education program. For this case study, one teacher education program in the southeastern United States was selected as the case site, and the case for this study is the process of student teacher placement. Semi-structured interviews, observation, and …


Advances In Active And Passive Integrated Photonic Devices On Thin-Film Lithium Niobate, Pooja S. Kulkarni Jan 2026

Advances In Active And Passive Integrated Photonic Devices On Thin-Film Lithium Niobate, Pooja S. Kulkarni

Graduate Studies Theses and Dissertations 2026

Thin-film lithium niobate (TFLN) has emerged as a powerful platform for integrated photonics, combining the exceptional electro-optic, nonlinear, and optical properties of bulk lithium niobate with the scalability and compactness of planar nanophotonic technologies. Building on these principles, advanced device architectures such as adiabatic dichroic filters have demonstrated exceptional spectral performance spanning over two octaves of bandwidth on the TFLN platform. Beyond reciprocal devices, it also offers promising pathways toward integrated nonreciprocal components. By leveraging broadband filtering structures and advanced nonlinear photonic design strategies, compact and monolithic optical isolators can be envisioned without relying on traditional magneto-optic materials. In the …


“I Am A Refugee Direct From Mississippi:” Drafting And Substitution As Muster Methods In Shaping Black Participation In The Union Army, 1863–1865, Carson R. Maschmeier Jan 2026

“I Am A Refugee Direct From Mississippi:” Drafting And Substitution As Muster Methods In Shaping Black Participation In The Union Army, 1863–1865, Carson R. Maschmeier

Graduate Studies Theses and Dissertations 2026

Historians have frequently emphasized voluntary enlistment as the primary means through which Black men entered military service, portraying military participation as an expression of autonomy and a pathway toward freedom and citizenship. Within this scholarship, few historians have examined how Black participation in the Union army as draftees and substitutes impacted Black men and their families. This thesis examines the role of drafting and substitution in shaping Black military participation in the Union Army during the American Civil War. By focusing on Pennsylvania's 8th United States Colored Troops (USCT), this study argues that drafting and substitution complicate the commonly accepted …


Toward Evidence-Based Disposition Assessment In Counselor Education: Advocating For Established Measures And Evaluating The Psychometric Properties Of The Pdca-Ra, Laura Rendon Finnell Jan 2026

Toward Evidence-Based Disposition Assessment In Counselor Education: Advocating For Established Measures And Evaluating The Psychometric Properties Of The Pdca-Ra, Laura Rendon Finnell

Graduate Studies Theses and Dissertations 2026

Professional dispositions are recognized as an essential component of counselor competence and are now explicitly included within accreditation standards. However, questions remain regarding how these characteristics should assessed in ways that are fair, systematic, and supported by empirical evidence. This two-manuscript dissertation focused on professional disposition assessment in counselor education. The first manuscript provides a conceptual examination of professional dispositions, counselor competence, and gatekeeping responsibilities while reviewing established disposition assessment instruments in counselor education. The manuscript advocates for the use of established disposition measures rather than relying solely on locally developed assessment procedures. The second manuscript presents an empirical evaluation …


Numerical Simulation Of Micro-Cutting Processes For The Estimation Of Material Fracture Toughness, Juan J. Lainez Jan 2026

Numerical Simulation Of Micro-Cutting Processes For The Estimation Of Material Fracture Toughness, Juan J. Lainez

Graduate Studies Theses and Dissertations 2026

Accurate determination of plane-strain fracture toughness is essential for structural integrity assessments of engineering components, yet conventional ASTM standardized testing methods require large, notched specimens that are impractical in many industrial and research contexts. This thesis presents a finite element method-based approach for estimating the mode I plane-strain fracture toughness of engineering materials from orthogonal micro-cutting simulations if the continuum damage mechanics-based fracture locus is calibrated. This method will eliminate the need for pre-cracked specimens while maintaining physically grounded fracture mechanics principles. The methodology applies to the Atkins energy-based cutting force model, in which the depth-independent intercept of the specific …


The Library Of Congress At A Crossroads: Executive Overreach And The Future Of Public Knowledge, Leslie A. Street, Amanda M. Runyon Jan 2026

The Library Of Congress At A Crossroads: Executive Overreach And The Future Of Public Knowledge, Leslie A. Street, Amanda M. Runyon

Library Staff Publications

This Article argues that the removal of the Librarian of Congress and the Register of Copyrights exposed a dual vulnerability: a constitutional breach of the separation of powers and a cultural threat to the nation’s knowledge infrastructure. The Library’s structural ambiguity—its simultaneous identity as a legislative library, national library, and copyright agency—has left it vulnerable to executive overreach. By asserting control over an institution designed to serve Congress and safeguard America’s intellectual heritage, the President destabilized a statutory framework that has endured for over two centuries. To protect both constitutional integrity and the Library’s role as custodian of national memory, …


Mat 2100 Calculus Iii Syllabus, Mei Xing Jan 2026

Mat 2100 Calculus Iii Syllabus, Mei Xing

Open Educational Resources

No abstract provided.


Stim1-Dependent Treg Dysfunction Promotes Cardiometabolic Hfpef: Insights From Patients And Animal Studies, Balaji Srinivas, Alluri Kiran, Hongmei Peng, Jiang Xu, Paula Fortuno, Jennifer May, Ismail El Moudden, Nour-Eddine Rhaleb, John M. Herre, Raymond L. Benza, Khalid Matrougui Jan 2026

Stim1-Dependent Treg Dysfunction Promotes Cardiometabolic Hfpef: Insights From Patients And Animal Studies, Balaji Srinivas, Alluri Kiran, Hongmei Peng, Jiang Xu, Paula Fortuno, Jennifer May, Ismail El Moudden, Nour-Eddine Rhaleb, John M. Herre, Raymond L. Benza, Khalid Matrougui

Department of Biomedical and Translational Sciences Faculty Publications

Background

Heart failure with preserved ejection fraction (HFpEF) arises from chronic cardiometabolic and vascular stress and is increasingly recognized as an inflammatory syndrome with immune dysregulation. Regulatory T cells (Tregs) are critical modulators of cardiovascular inflammation, yet the mechanisms driving Treg dysfunction in HFpEF remain poorly defined. stromal interaction molecule 1 (STIM1)-dependent calcium signaling is a key stress-responsive pathway in immune cells; however, its role in Treg maladaptation during HFpEF remains unknown.

Methods

Circulating Tregs from patients with and without HFpEF were analyzed for abundance, STIM1 expression, and stress-associated signaling pathways. To establish causality, mice with Treg-specific deletion of STIM1 …


Reconstituting A Constitution, And A Republic: The Architecture Of Authoritarian Rule, J. Maria Glover Jan 2026

Reconstituting A Constitution, And A Republic: The Architecture Of Authoritarian Rule, J. Maria Glover

Georgetown Law Faculty Publications and Other Works

A constitution can be remade without tearing it down, or even changing a single word. It is done by law.

“The judicial power is vested in one Supreme Court and in such inferior courts as Congress may establish,” whose “province and duty” it is to “say what the law is.” U.S. Const. Art. III §1; Marbury v. Madison, 5 U.S. 1 (Cranch) 137 (1803). It is not the power to remake the Constitution that grants it.

The Supreme Court is turning the inherited powers that hold power to law into instruments of its own aggrandizement. It is taking authority from …