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Influence Of Predation Risk On Elk Feeding Behavior In A Multi-Predator Environment, Rosemarie C. Pugh
Influence Of Predation Risk On Elk Feeding Behavior In A Multi-Predator Environment, Rosemarie C. Pugh
All Graduate Theses and Dissertations, Fall 2023 to Present
Sometimes predators don’t just affect prey by killing them, they can also change how prey behave. For example, animals may spend more time watching for danger and less time eating, which could affect their health and survival. In Yellowstone National Park, past research has suggested that elk may reduce feeding because they are trying to avoid predators like wolves and cougars. However, most previous studies have only looked at elk behavior during the daytime and have often looked at responses from single predators rather than multiple.
In this study, I used high-resolution tracking collars equipped with motion sensors to directly …
Influence Of Coterie On Utah Prairie Dog Translocation Success, Bonnie Stokes
Influence Of Coterie On Utah Prairie Dog Translocation Success, Bonnie Stokes
All Graduate Theses and Dissertations, Fall 2023 to Present
The Utah prairie dog (Cynomys parvidens) is a threatened species found in southwestern Utah. Utah prairie dogs are small, burrowing squirrels that live in family groups called coteries. Translocation, the intentional capture, movement, and release of animals from one location to another, has been widely used to aid in their recovery; however, post-translocation survival remains low. The primary objective of this study was to evaluate the effect of translocating Utah prairie dogs as intact coteries on post-translocation survival.
This study was conducted within the West Desert Recovery Unit in Iron and Beaver Counties, Utah, during July–October 2023 and …
Effects Of Mineral Supplementation On Ovine Performance, Forage Selectivity, And Rangeland Utilization In Southern Utah, Ryan A. Spurling
Effects Of Mineral Supplementation On Ovine Performance, Forage Selectivity, And Rangeland Utilization In Southern Utah, Ryan A. Spurling
All Graduate Theses and Dissertations, Fall 2023 to Present
Sheep producers in the Intermountain West region of the US rely on productive rangeland ecosystems that vary widely in forage composition and nutrient availability. As such, supplementation is often necessary to offset dietary deficiencies. Soils and forages grown on rangelands are known to be highly variable in mineral content. Even so, a third to half of the producers in the Intermountain West choose not to provide a complete mineral supplement. Rangeland environments are often characterized by rugged geographical features that make optimal supplement placement difficult. New advances in technology have allowed us to measure individual animal intake on rangelands via …
Alfalfa Yield, Quality, And Nutrient Use Response To Pivot Sprinkler Technology, Deficit Irrigation, And Genetics, Dakota Boren
Alfalfa Yield, Quality, And Nutrient Use Response To Pivot Sprinkler Technology, Deficit Irrigation, And Genetics, Dakota Boren
All Graduate Theses and Dissertations, Fall 2023 to Present
In water limited environments, alfalfa is often criticized for its high water use, prompting implementation of new irrigation technologies, deficit irrigation, and adapted crop genetics. Cumulative potential benefits from combining, or stacking, these water-optimizing practices have not been identified. The objective of this on-farm research study was to determine how irrigation technologies, deficit irrigation, genetics, and combinations of these practices impact alfalfa yield and forage quality. Trials were conducted at three sites in Utah from 2020 to 2022 on young alfalfa stands (establishment and first one to three production years). Treatments included five irrigation technologies, four irrigation rates, and two …
A Mixed Methods Analysis On The Effect Of Active Learning On Extraneous Cognitive Load Within Undergraduate Statistics Courses, Michelle Brady Rich
A Mixed Methods Analysis On The Effect Of Active Learning On Extraneous Cognitive Load Within Undergraduate Statistics Courses, Michelle Brady Rich
All Graduate Theses and Dissertations, Fall 2023 to Present
Students enrolled in college-level statistics courses often lack the foundational skills of statistical concepts which can potentially lead to increased mental load. Additionally, the curricula within undergraduate classes often focus on traditional theory with little student exploration or participation. This combination of increased mental load and passive lectures can be explored through the Cognitive Load Theory (CLT). CLT examines how new information enters the limited capacity of an individual’s working memory and how exceeding this capacity affects the ability to transfer the information to long-term memory. This research focused on the extraneous cognitive load, or the load imposed by the …
Examining Motivations And Perceptions In Secondary Technology And Engineering Education: A Gendered Analysis Using The Fit-Choice Scale, Abigail Villanueva
Examining Motivations And Perceptions In Secondary Technology And Engineering Education: A Gendered Analysis Using The Fit-Choice Scale, Abigail Villanueva
All Graduate Theses and Dissertations, Fall 2023 to Present
This study examined why individuals choose to become secondary technology and engineering education (TEE) teachers and whether motivations differ between men and women. TEE programs help prepare students for careers in science, technology, engineering, and math (STEM), yet schools face teacher shortages and low female representation in the field. Understanding what draws people to this profession can support better recruitment and retention efforts. Sixty-six current TEE teachers completed a survey about the factors that influenced their decision to teach. Overall, the strongest motivations were a personal interest in teaching, enjoyment of working with young people, and the desire to make …
Food-Form Delivery Of Spore-Forming Probiotics As An Alternative To Gavage In Animal Models, Aubreyona Faith Migliori Skalka
Food-Form Delivery Of Spore-Forming Probiotics As An Alternative To Gavage In Animal Models, Aubreyona Faith Migliori Skalka
All Graduate Theses and Dissertations, Fall 2023 to Present
Western dietary patterns are characterized by nutrient-poor, calorie-rich diets and have been linked to poor health outcomes and gut inflammation phenotypes. Probiotics are often taken to support gut health, but many beneficial bacteria do not survive transport through the digestive system to produce any effect. Spore-forming bacteria, such as Bacillus coagulans, are more resilient due to their hardy outer coat which aids in survival through many obstacles encountered in the gastrointestinal tract, including acidic stomach conditions. In research studies, probiotics are usually given to mice through a procedure called oral gavage, where a tube is used to deliver the …
Domestic Cow Of Plenty: Gender And Womanhood In The Bhāgavata Purāṇa, Harshika Ajay Gupta
Domestic Cow Of Plenty: Gender And Womanhood In The Bhāgavata Purāṇa, Harshika Ajay Gupta
All Graduate Theses and Dissertations, Fall 2023 to Present
This thesis examines gender and womanhood in the Bhāgavata Purāṇa (Bhāgavata), a Sanskrit text from the 10th century CE that holds an important theological and cultural position in contemporary Hindu traditions. It decodes the Bhāgavata’s unique perspectives on the following: (1) gender, sex, sexuality, and reproduction, (2) women’s social normativity, and (3) women’s personhood and agency. This thesis argues that the Bhāgavata contains a unique theorization of gender and sex as well as a positive valuation of femininity, and that it imbues its narratives with practical resources and actions to recognize and expand the agentive capacity of women.
For scholars …
Mechanisms Of Life History Trade-Offs In The Evolution Of Eusociality, Frances Katherine Hunter
Mechanisms Of Life History Trade-Offs In The Evolution Of Eusociality, Frances Katherine Hunter
All Graduate Theses and Dissertations, Fall 2023 to Present
When faced with stressors such as pathogen infection, organisms must invest energy in defense or risk death. Because resources are limited, mounting an immune response often comes at the expense of other costly activities such as reproduction. The costs of immunity are shaped by factors including behavior, nutrition, age, and evolutionary history.
Social insects (e.g., ants, bees, and wasps) offer a powerful system for studying these trade-offs because queens in these colonies appear to escape them—living long lives while reproducing prolifically. Bees, which include species that range from those which nest solitarily to those with complex social systems and many …
Effect Of Agroecological Feeding Systems Of Dairy Cattle On The Nutritional Composition Of Milk, Sree Bhavya Immadi
Effect Of Agroecological Feeding Systems Of Dairy Cattle On The Nutritional Composition Of Milk, Sree Bhavya Immadi
All Graduate Theses and Dissertations, Fall 2023 to Present
How food is produced can influence both its nutritional quality and its impact on the environment. In recent years, regenerative (agroecological) farming practices have gained attention for their potential to improve soil health, biodiversity, and the nutritional value of foods. In dairy production, these practices often involve growing more diverse forage crops, reducing soil disturbance, and relying less on monoculture-grown feed rations. However, there is still limited real-world evidence showing how these practices affect the nutritional composition of milk produced on commercial dairy farms.
This dissertation explores how regenerative feeding and feed production practices influence the nutritional quality of milk, …
Effects Of Serum And Commercial Serum-Free Media On Development Of In Vitro Produced (Ivp) Embryos In Cattle, Kyla Miller
Effects Of Serum And Commercial Serum-Free Media On Development Of In Vitro Produced (Ivp) Embryos In Cattle, Kyla Miller
All Graduate Theses and Dissertations, Fall 2023 to Present
Serum-containing media has been shown to increase incidence of large offspring syndrome and to alter gene expression, protein synthesis, and cell signaling. These factors together can result in increased pregnancy loss when combined with assisted reproduction technologies. However, there are very few direct comparisons of commercial serum-free media (IVF Bioscience™) and serum-containing media on both IVF and cloned embryo development in cattle. The aim of this study was to determine the role of serum in oocyte maturation and subsequent embryo development. Three culture systems, including in vitro maturation (IVM) and in vitro culture (IVC), were used in this study. Both …
Gradient Based Optimization Methods For Robust Learning And Biomedical Signal Modeling, Jarrod Mau
Gradient Based Optimization Methods For Robust Learning And Biomedical Signal Modeling, Jarrod Mau
All Graduate Theses and Dissertations, Fall 2023 to Present
This dissertation explores how modern artificial intelligence techniques can be used to better understand complex biological data. Specifically, it develops new machine learning based methods and applies them to two important biomedical problems: analyzing brain signals and studying protein behavior.
The first part of the work introduces a new machine learning approach designed to improve how computers classify structured data. Traditional neural networks are powerful but can sometimes generalize poorly. This research proposes a method that combines the flexibility of neural networks with the reliability of ensemble techniques, leading to more robust and accurate predictions across different types of datasets. …
Exploring The Correlation Between Malnutrition And Food And Nutrition Insecurity In Inflammatory Bowel Disease, Heather Burr
Exploring The Correlation Between Malnutrition And Food And Nutrition Insecurity In Inflammatory Bowel Disease, Heather Burr
All Graduate Theses and Dissertations, Fall 2023 to Present
Inflammatory Bowel Disease (IBD) may increase the risk of malnutrition because of nausea, vomiting, diarrhea and restrictive eating. In addition, patients with IBD may experience food and nutrition insecurity. Therefore, we conducted an online survey to assess risk of malnutrition and food and nutrition insecurity among adult patients with IBD in outpatient and community settings. Patients were recruited between July and December 2025, aiming to reach adults in the Rocky Mountain Region diagnosed with IBD. Data collected included demographics, health-related factors, risk of nutrition insecurity, risk of food insecurity, and barriers and facilitators to dietary management of IBD.
Fifty-seven patients …
The Rhythm Of Reform, Michael Waldman
The Rhythm Of Reform, Michael Waldman
Cardozo Law Review
This year, we celebrate the 250th anniversary of our independence. In January 1776, Thomas Paine published Common Sense. Paine was an immigrant who had arrived only two years before. The pamphlet went viral, a widely bootlegged bestseller with 120,000 copies sold in its first three months in print. It galvanized support for independence and argued that the collection of colonies should become a republic. Paine wrote: “[I]n America THE LAW IS KING.”
Is that still true? We are finding out.
Today our Constitution and the institutions of self-government face extraordinary pressure. In the first two months of 2026 alone, …
The Relationship Between Sports Related Head Injuries, Mental Health And Academic Performance In University Student-Athletes, Odyssey Keller
The Relationship Between Sports Related Head Injuries, Mental Health And Academic Performance In University Student-Athletes, Odyssey Keller
Electronic Theses and Dissertations
Student athletes face many challenges when it comes to participating in team sports, one of the most notable being sport-related head injuries. Concussions are a growing concern since they have the potential to impact mental health and academic performance long-term. While many athletes report recovery within weeks, some continue to struggle with impairments in their psychological functioning and overall mental well-being that interferes with academic performance over time. Many of the standardized protocols in place for concussion management vary across institutions. This study aimed to address gaps in the existing literature by assessing concussion history, mental health and academic challenges …
The Legal Framework For Direct Ocean Carbon Capture And Storage (Volume 2: The United States), Korey Silverman-Roati, Romany M. Webb
The Legal Framework For Direct Ocean Carbon Capture And Storage (Volume 2: The United States), Korey Silverman-Roati, Romany M. Webb
Sabin Center for Climate Change Law
This paper, the second in a series of two, focuses on the U.S. legal framework for the marine carbon dioxide removal (mCDR) approach of direct ocean carbon capture and storage (DOCCS). The first explores DOCCS governance under international law and is available here: https://scholarship.law.columbia.edu/sabin_climate_change/271/.
DOCCS aims to remove some of the carbon currently stored in the ocean and thereby enable it to uptake additional carbon dioxide from the atmosphere. DOCCS is still undergoing research, but early studies suggest it could have significant carbon dioxide removal potential. However, DOCCS could also present environmental and other risks, including from the construction …
High-Penetrance Rare Variants Underlying Familial Lung Cancer Risk: Insights From Genetic Epidemiology Of Lung Cancer Consortium, Yanhong Liu, Yafang Li, Jinyoung Byun, Vikram R Shaw, Claudio Pikielny, Bo Peng, Chao Cheng, Spiridon Tsavachidis, Xiangjun Xiao, Dakai Zhu, Younghun Han, Ivan P Gorlov, Olga Y Gorlova, Michael Cole, Colette R Gaba, Erin L Crawford, Kristen Purrington, Ellen L Goode, Ping Yang, James Mckay, John K Field, Geoffrey Liu, Rayjean J Hung, Jun Xia, Jiyeon Choi, Matthew B Schabath, Jaclyn Lopiccolo, David C Christiani, Joan Bailey-Wilson, Ann G Schwartz, James C Willey, Diptasri Mandal, Susan M Pinney, Christopher I Amos
High-Penetrance Rare Variants Underlying Familial Lung Cancer Risk: Insights From Genetic Epidemiology Of Lung Cancer Consortium, Yanhong Liu, Yafang Li, Jinyoung Byun, Vikram R Shaw, Claudio Pikielny, Bo Peng, Chao Cheng, Spiridon Tsavachidis, Xiangjun Xiao, Dakai Zhu, Younghun Han, Ivan P Gorlov, Olga Y Gorlova, Michael Cole, Colette R Gaba, Erin L Crawford, Kristen Purrington, Ellen L Goode, Ping Yang, James Mckay, John K Field, Geoffrey Liu, Rayjean J Hung, Jun Xia, Jiyeon Choi, Matthew B Schabath, Jaclyn Lopiccolo, David C Christiani, Joan Bailey-Wilson, Ann G Schwartz, James C Willey, Diptasri Mandal, Susan M Pinney, Christopher I Amos
Faculty, Staff and Students Publications
Introduction: Rare, deleterious germline variants are key contributors to inherited lung cancer (LC) risk. The Genetic Epidemiology of LC Consortium (GELCC) has curated valuable high-risk LC families and is uniquely positioned to uncover rare, high-penetrance variants underlying familial LC (FLC).
Methods: We performed whole-genome and exome sequencing on germline DNA from 120 high-risk LC families (177 FLC cases, 309 unaffected relatives). We prioritized rare (allele frequency < 1% in the genome aggregation database), potentially deleterious variants present in two or more FLC cases. These variants were then validated in 10,085 sporadic LC (SLC) cases and 612,970 controls.
Results: We identified 118 candidate variants, 28 of which were validated in SLC with strong statistical support. We discovered a novel pathogenic axis of three truncating variants in GALNT6, MUC4, and ERBB3 genes, which …
Interplay Between Genetic Ancestry, Self-Reported Race And Ethnicity, And Clinical Factors In Pediatric Acute Lymphoblastic Leukemia: A Redial Consortium Report, Pragati Kore, Jennifer M Geris, Maria Leon-Camarena, Maria I Castellanos, Olga A Taylor, Veronica Garcia-Morales, Austin L Brown, Pagna Sok, Jeremy M Schraw, Van Huynh, Kathleen F Ludwig, Laura J Klesse, Sandi L Pruitt, Amy E Hughes, Kevin Tien, Kenneth M Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Maria M Gramatges, Elizabeth G Atkinson, Philip J Lupo, Michael E Scheurer, Karen R Rabin
Interplay Between Genetic Ancestry, Self-Reported Race And Ethnicity, And Clinical Factors In Pediatric Acute Lymphoblastic Leukemia: A Redial Consortium Report, Pragati Kore, Jennifer M Geris, Maria Leon-Camarena, Maria I Castellanos, Olga A Taylor, Veronica Garcia-Morales, Austin L Brown, Pagna Sok, Jeremy M Schraw, Van Huynh, Kathleen F Ludwig, Laura J Klesse, Sandi L Pruitt, Amy E Hughes, Kevin Tien, Kenneth M Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Maria M Gramatges, Elizabeth G Atkinson, Philip J Lupo, Michael E Scheurer, Karen R Rabin
Faculty, Staff and Students Publications
Background: Pediatric acute lymphoblastic leukemia (ALL) is the most common cancer in children, and its incidence and outcomes vary by race and ethnicity.
Methods: The Reducing Ethnic Disparities in Acute Leukemia (REDIAL) Consortium has assembled a cohort of patients < 25 years at diagnosis to examine genetic and neighborhood-level factors influencing ALL. As the cohort is ongoing, for this report, we examined sociodemographic and cytogenetic factors that might be associated with ALL outcome disparities.
Results: Among 2,512 patients diagnosed between 2005 and 2020, we observed distinct patterns of genetic ancestry and residential characteristics across self-reported race and ethnicity. Latino children, who comprised 55.3% of the cohort, had a mean Amerindigenous ancestry proportion of 50.9%, whereas non-Latino White children exhibited a predominantly European ancestry (mean = 78%). Neighborhood-level analysis revealed significant socioeconomic and geographic differences by …
Girl Grammar: A Syntactic And Pragmatic Analysis Of Girl And Miss Girl, Evelyn A. Powers
Girl Grammar: A Syntactic And Pragmatic Analysis Of Girl And Miss Girl, Evelyn A. Powers
Senior Honors Papers / Undergraduate Theses
Based on observation, personal interaction, and informal interviews/linguistic judgements, this thesis presents the unique and asymmetrical grammaticality patterns of the terms Girl and Miss Girl. To account for these asymmetries, I provide a syntactic framework rooted in Minimalism and Rizzi’s (1997) expanded CP hypothesis, alongside a pragmatic explanation based on Barros and Frank’s (2023) attentional maintenance and attentional shift paradigm.
Miss Girl behaves as a typical R-expression when used as a 3rd person subject, but Girl has a very restricted distribution, inconsistent with either R-expressions or pronouns (it is acceptable as the subject of a main clause, ungrammatical in object …
Adaptive Evolution Of Gene Regulatory Networks In Mammalian Neocortex, Zhuo Li, Linda J Richards, Et Al.
Adaptive Evolution Of Gene Regulatory Networks In Mammalian Neocortex, Zhuo Li, Linda J Richards, Et Al.
2020-Current year OA Pubs
Mammals have evolved a more complex brain, exemplified by the transformation of the single-layer dorsal cortex of excitatory projection neurons (ExNs) in ancestors into a multilayered cerebral neocortex
Pulse Wave Velocity In Atrial Fibrillation: A Scoping Review Of Clinical Relevance, Oren G. Nedjar, Zaneh Kahook, Syed Maaz Shah, Christos G. Mihos, Marc M. Kesselman
Pulse Wave Velocity In Atrial Fibrillation: A Scoping Review Of Clinical Relevance, Oren G. Nedjar, Zaneh Kahook, Syed Maaz Shah, Christos G. Mihos, Marc M. Kesselman
Student Publications
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with high morbidity, mortality, and healthcare burden. Arterial stiffness (AS) alters cardiac loading conditions and contributes to ventricular arterial uncoupling (VAC), diastolic dysfunction, and atrial remodeling. Pulse wave velocity (PWV) is the standard noninvasive measure of AS, but its role across the spectrum of AF has not been clearly defined. This scoping review assessed the existing literature on PWV and AF, with attention to disease onset, clinical characteristics, progression, treatment response, and outcomes. A scoping review was conducted following Preferred Reporting Items for Systematic reviews and Meta-Analyses …
Stance And Gait Analysis Of Apollo Astronauts On The Moon, Faye Y Chiou-Tan, Conrad Li, Jason P Caffrey, Millard Reschke, Timothy R Macaulay
Stance And Gait Analysis Of Apollo Astronauts On The Moon, Faye Y Chiou-Tan, Conrad Li, Jason P Caffrey, Millard Reschke, Timothy R Macaulay
Faculty, Staff and Students Publications
Introduction/aim: As humans return to the Moon, safe efficient ambulation and fall prevention on the lunar surface are key concerns. The analysis of gait from archived Apollo mission video footage is now possible with pose estimation video analysis software. Thus, this study aims to retrospectively quantify parameters of Apollo astronauts' stance and gait on the Moon.
Methods: Publicly available National Aeronautics and Space Administration (NASA) footage of astronauts ambulating on the Lunar surface was examined using body pose analysis software. Goniometric lower limb joint/torso angles and width of base of stance and gait were derived. Gait cycle stance phase, swing …
Single-Nuclei Transcriptomic Profiling Of Human Myocardium In Long-Chain 3-Hydroxyacyl-Coenzyme A Dehydrogenase Deficiency, Hanna J Tadros, Diwakar Turaga, Yi Zhao, Chang-Ru Tsai, Lalita Wadhwa, Debra L Kearney, Iki Adachi, Xiao Li, James F Martin
Single-Nuclei Transcriptomic Profiling Of Human Myocardium In Long-Chain 3-Hydroxyacyl-Coenzyme A Dehydrogenase Deficiency, Hanna J Tadros, Diwakar Turaga, Yi Zhao, Chang-Ru Tsai, Lalita Wadhwa, Debra L Kearney, Iki Adachi, Xiao Li, James F Martin
Faculty, Staff and Students Publications
No abstract provided.
A Smoking-Related Plasma Protein Score And Smoking-Related Cancer Risk And Mortality In The Atherosclerosis Risk In Communities Study, Meng Ru, Christopher Douville, Aghiles Guenoun, Hana Zahed, Christie M Ballantyne, Kenneth R Butler, Josef Coresh, David J Couper, Panagis Galiatsatos, Marc J Gunter, Ron C Hoogeveen, Mattias Johansson, Corinne E Joshu, P Martijn Kolijn, Christina M Lill, Jiayun Lu, Michael T Marrone, Giovanna Masala, David C Muller, Anna E Prizment, Raul Zamora-Ros, Nilanjan Chatterjee, Adrienne Tin, Elizabeth A Platz
A Smoking-Related Plasma Protein Score And Smoking-Related Cancer Risk And Mortality In The Atherosclerosis Risk In Communities Study, Meng Ru, Christopher Douville, Aghiles Guenoun, Hana Zahed, Christie M Ballantyne, Kenneth R Butler, Josef Coresh, David J Couper, Panagis Galiatsatos, Marc J Gunter, Ron C Hoogeveen, Mattias Johansson, Corinne E Joshu, P Martijn Kolijn, Christina M Lill, Jiayun Lu, Michael T Marrone, Giovanna Masala, David C Muller, Anna E Prizment, Raul Zamora-Ros, Nilanjan Chatterjee, Adrienne Tin, Elizabeth A Platz
Faculty, Staff and Students Publications
Background: Self-reported smoking may not fully capture individualized risk of smoking-related cancer, but circulating proteins may reflect biological consequences of smoking. Thus, we developed a score based on smoking-related proteins and evaluated its association with smoking-related cancer.
Methods: This prospective cohort study included 10 563 participants aged 47-70 years in the Atherosclerosis Risk in Communities study. Plasma proteins were measured using the SomaScan Platform (SomaLogic Operating Co, Inc). The score was constructed from proteins associated with current smoking, pack-years, or recent quitting identified by linear regression and elastic net regression. Cox regression was used to estimate adjusted hazard ratios and …
Engineering Translational Biosensing Tools Forparkinson’S Disease, Mercedes Terry
Engineering Translational Biosensing Tools Forparkinson’S Disease, Mercedes Terry
Theses and Dissertations
Parkinson’s disease is a progressive neurodegenerative disorder characterized by motor dysfunction and early cognitive decline. Diagnosis and monitoring remain largely symptom-driven, relying on clinical scales that capture disease only after significant neurodegeneration has occurred. These assessments are inherently subjective, episodic, and insensitive to early-stage pathology, limiting both timely diagnosis and the ability to track disease progression or therapeutic response. The lack of objective, quantitative biomarkers for both molecular pathology and cognitive impairment remains a major barrier to advancing precision medicine approaches in Parkinson’s disease. This dissertation approaches Parkinson’s disease from two complementary fronts: molecular detection of alpha-synuclein pathology and quantitative …
Mechanistic Insights Into Hla-Dependent Tumor Microenvironment Modulation And Tcr Vβ Activation Induced By Staphylococcal Enterotoxin I And Staphylococcal Enterotoxin G In Melanoma, Abiola Michael Sholarin
Mechanistic Insights Into Hla-Dependent Tumor Microenvironment Modulation And Tcr Vβ Activation Induced By Staphylococcal Enterotoxin I And Staphylococcal Enterotoxin G In Melanoma, Abiola Michael Sholarin
Theses and Dissertations
Immunotherapies have transformed cancer treatment by enabling durable antitumor responses through targeted activation of the immune system. Among the most potent immune-stimulatory molecules are bacterial superantigens, which activate large fractions of the T-cell repertoire through simultaneous binding of major histocompatibility complex (MHC) class II molecules and conserved regions of the T-cell receptor (TCR) β-chain. Because these interactions are strongly human MHC–restricted, HLA-transgenic mouse models are essential for evaluating the therapeutic potential and safety of superantigen-based immunotherapies.This dissertation investigates the antitumor activity and mechanisms of action of two superantigens encoded within the Staphylococcus aureus enterotoxin gene cluster—Staphylococcal enterotoxin I (SEI) and …
Beyond The Manual: Training Troubleshooting Skills Through Augmented Reality, Lawrence Allen Smith Jr.
Beyond The Manual: Training Troubleshooting Skills Through Augmented Reality, Lawrence Allen Smith Jr.
Theses and Dissertations
Many industrial maintenance departments implement and utilize Augmented Reality Technology (ART) and Augmented Reality Technical Training (ARTT) in their day-to-day operations. This study aims to examine technicians' troubleshooting skills by exploring two main questions: (1) how these skills are impacted by Cognitive Load Theory (CLT), and (2) how they are influenced by using either paper manuals or ARTT manuals. The research will compare the effects of traditional paper manuals and ARTT manuals on the learning outcomes of troubleshooters. The measurements of learning outcomes will include cognitive ability, professional specific knowledge, and skill retention. Keywords: augmented reality (AR), industrial maintenance, augmented …
Open Chromatin-Guided Analysis Of Cell-Free Dna For Inferring Regulatory Landscapes In Cancer Detection, Monitoring, And Therapeutic Response, Sakuntha Devaka Gunarathna
Open Chromatin-Guided Analysis Of Cell-Free Dna For Inferring Regulatory Landscapes In Cancer Detection, Monitoring, And Therapeutic Response, Sakuntha Devaka Gunarathna
Theses and Dissertations
Conventional cancer diagnosis and monitoring rely on imaging and tissue biopsies. Imaging is constrained by resolution, while biopsies are invasive, limited in capturing tumor heterogeneity, and challenging to perform repeatedly over time. Liquid biopsy has emerged as a minimally invasive alternative that enables real-time assessment of tumor-derived material in circulation. Among its components, cell-free DNA (cfDNA) has gained significant attention as a promising biomarker for cancer detection and disease monitoring. However, most current cfDNA approaches rely on mutation- and methylation-based signals, which, while informative, can be limited by low tumor fraction, biological heterogeneity, and reduced sensitivity in early-stage disease. In …
The Effects Of Geography, Forage Sources And Seasonality On Microbial Communities In Honey Bees, Adam Pachl
The Effects Of Geography, Forage Sources And Seasonality On Microbial Communities In Honey Bees, Adam Pachl
Theses and Dissertations
There has been growing research examining the effects on honey bee nutrition through their gut microbial communities. While there is some consensus about the core composition of the honey bee gut, there has been very little work to examine if regional or seasonal differences affect the microbiome. To examine if seasonal or regional differences have any impact on the composition of the gut microbiomes on North Dakota honey bees, worker bees were sampled from commercial honey bee colonies both pre and post honey flow in 2022 in six different regions of North Dakota. The gut bacteria from the bees were …
Climate Messages In An Ai-Integrated Experiment: Interpretive Divergence, Policy Support, And A New Resonance Consistency Framework, Jayme Colosimo
Climate Messages In An Ai-Integrated Experiment: Interpretive Divergence, Policy Support, And A New Resonance Consistency Framework, Jayme Colosimo
Theses and Dissertations
This dissertation examined how environmental frames—particularly “Mother Earth” and “Mother Nature”—influence public support for climate policy and how these effects differ across demographic groups. Using a mixed-methods explanatory sequential design, the study executed a media survey experiment (N = 470) followed by semi-structured expert interviews to assess responses to two primes using a conventional corporate media message, and a message with similar content that was generated by Artificial Intelligence (AI).
Quantitative findings showed that these metaphors generated uneven and sometimes divergent priming effects. Some groups—most notably White male Republicans—reported higher support for environmental policy under the conventional media prime. Under …