Digital Commons Network^™

Reward Representation Learning, Gregory M. Hyde

Dartmouth College Ph.D Dissertations

The \emph{Markov decision process} (MDP) has long served as the canonical model for sequential decision-making. However, it assumes that the reward function is Markov with respect to a given state representation---an assumption that often does not hold in practice. Instead, agents typically only perceive streams of observations and actions and must infer the latent structure according to which reward unfolds over time. From this perspective, reward prediction is initially non-Markov, reflecting a mismatch between the agent's current representation and the underlying structure of the environment.

In this thesis, we advance the view that reward is not simply a signal to …

Data-Driven Multimodal Mri Representation Learning For Subtype Discovery And Disease Progression Modeling In Parkinson’S Disease, Zihan Zhou

McKelvey School of Engineering Graduate Student Theses & Dissertations

Parkinson’s disease (PD) exhibits substantial clinical and neuroanatomical heterogeneity, limiting robust patient stratification and clinically meaningful progression modeling from MRI. We propose a unified multimodal 3D generative representation-learning framework that learns an interpretable latent space from co-registered baseline T1/T2 MRI with an edge-aware channel. Confound-corrected latent embeddings support unsupervised subtype discovery, while disease duration provides weak supervision to orient a continuous progression axis. On an independent external cohort (PPMI, N=171), the discovery-trained subtype structure shows significant partial replication (ARI=0.35; permutation test p=0.001) and enables longitudinal clinical stratification: mixed-effects modeling reveals subtype-dependent MDS-UPDRS III progression, with the strongest effect in subtype …

Ligand-Based Pharmacophore Modeling And Structure-Based Virtual Screening For Identifying Potential Therapeutic Agents Targeting The Sars-Cov-2 Spike Protein-Ace2 Receptor Interaction, Timoteo Delgado-Maldonado, Gilberto Vargas-Salas, Debasish Bandyopadhyay, Adriana Moreno-Rodriguez, Eyra Ortiz-Pérez, Gildardo Rivera-Sanchez

School of Integrative Biological & Chemical Sciences Faculty Publications

Coronavirus disease (COVID-19) remains a global health concern due to its high mortality and morbidity. In this study, we combined ligand-based pharmacophore modeling (LBPM) with structure-based virtual screening (SBVS) to identify novel inhibitors targeting the SARS-CoV-2 spike protein. Ligands from the MolPort database were screened via docking and molecular dynamics simulations at the receptor-binding domain (RBD). Four compounds showed promising docking scores (-8.7 to -6.4 kcal/mol) and dynamic stability (root mean square deviation < 5 Å). In vitro assays confirmed that compounds C3 (IC50 = 0.03 µM) and C4 (IC50 = 10.4 µM) effectively inhibited spike-ACE2 binding with low cytotoxicity (CC50 > 100 µM). These findings show the efficacy of the LBPM technique and highlight 1H-pyrazol-5-ol derivatives as potential building blocks for developing new antiviral agents against SARS-CoV-2.

Considerations When Designing In Vivo Protocols For Conducting Biomechanical Research Of The Shoulder Joint In Hockey Athletes, Kylie Giesler

Honors Program Theses

While the numbers and details of hockey-related injuries are variable across sources due to variations in sample age, sex, location, and confidentiality of many large hockey leagues, a 2023 narrative review study identified more than 100,000 upper extremity injuries documented in research since 2000. Nearly half of those injuries were to the shoulder with common injuries being acromioclavicular joint sprains, shoulder instability and dislocations, labral and rotator cuff tears, and clavicle fractures. In respect to the National Hockey League (NHL), the highest level of play in ice hockey, 12% of all injuries are to the shoulder, second only to head …

Promoting Healthy Relationships Among Youth: A Community Based Educational Intervention, Cynthya N. Carrillo

Capstone Projects and Master's Theses

Unhealthy relationship behaviors among youth, including poor communication, lack of boundaries and normalization of control, remain a significant public health concern. This capstone project was implemented at Teen Health Outreach, a program within Santa Cruz County Public Health Department that provides sexual health education and outreach to youth. The community served included youth ages 12-18, with a focus in Watsonville, a diverse and underserved population with limited access to culturally responsive health education. The project involved the development and facilitation of an interactive healthy relationships workshop designed to increase knowledge of consent, communication and relationship “red, yellow and green flags,” …

House Of Ill-Fame: A Historical, Cartographic, And Archaeological Study On The Spatial Evolution Of Commercial Sex Work In New Orleans, 1875 – 1925, Austin Roebuck

LSU New Orleans Theses and Dissertations

This research examines the historic spatiality of commercial sex‑work in New Orleans by analyzing targeted addresses associated with the trade across three census years. Using the establishment and closure of Storyville (1897–1917) as a temporal frame, it compares demographic patterns in dwellings labeled as “houses of ill fame” in 1880, 1900, and 1920 to trace changes in household composition and social identity. Sanborn Fire Insurance Maps, newspapers, and city directories contextualize these patterns within three ten‑year intervals (1875–1885, 1895–1905, 1915–1925), revealing how sex‑work spaces were regulated, represented, and embedded in the urban landscape. The study also incorporates an archaeological assemblage …

Green Synthesis And Characterization Of Carbon Dots From Date Seeds For Antimicrobial Applications, Mariam Rami Hamdan

Theses

This thesis focuses on the synthesis and functionalization of Carbon Dots (CDs) derived from date seeds, followed by their conjugation with different antibiotics for antimicrobial applications. Carbon dots have gained increasing popularity due to their unique optical characteristics, surface properties, and biocompatibility. On the other hand, the utilization of date seeds offers a sustainable route towards obtaining value-added nanomaterials from agricultural waste. The central aim of this project is to develop and characterize CDs from date seeds and investigate their possible use as antibiotic carriers to improve antibacterial efficacy. The CDs were prepared using a green, cost-effective method and characterized …

Effects Of Culturally (Queer) Responsive Teaching On Lgbtq+ Students, Samantha L. Alonso

Capstone Projects and Master's Theses

Culturally Responsive Teaching (CRT) has been thoroughly researched, and its effects have been well documented. However, when responding to Cultural diversity within the classroom, most researchers and educators focus on racially, ethnically, and linguistically diverse cultures. Despite this, CRT has proven its effectiveness for all students, and can be adapted for any minority culture. This study aims to explore the effectiveness of CRT for Queer students. As well as, the barriers, limitations, and hesitations in regards to its implementation. Using surveys conducted on students and educators alike, insights are provided in regards to student experiences and educators perspectives. Additionally, a …

2024 Annual Operations And Maintenance Report 2024 Bres Annual Summary Report For Work Completed In Quadrant 4, Butte-Silver Bow Department Of Reclamation And Environmental Services

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Board Of Trustees Meeting Minutes 2026-05-01, Bowling Green State University

Board of Trustees Meeting Minutes

The official meeting minutes of Bowling Green State University's Board of Trustees.

"Am I A Man Or A Muppet": A Rhetorical Analysis Of Generative Ai’S Representation Of Gender, Jessica Boaz

Electronic Theses and Dissertations

This thesis examines how generative artificial intelligence constructs and performs gender roles through a rhetorical analysis of the fully AI-generated podcast Fairytale Forensics. Drawing on theories of constitutive rhetoric, stereotyping, and McLuhan’s approach to the medium, this thesis investigates how AI-generated hosts interpret classic fairy tales while simultaneously reproducing and negotiating gender norms through the lens of prosopopoeia, metonymy and synecdoche. These performances rely on normative gender stereotypes that align with broader societal expectations, thereby potentially reinforcing existing cultural assumptions about masculinity and femininity. Ultimately, it demonstrates that AI-generated discourse does not merely reflect human biases but actively participates in …

Detection Of Biological Molecules Using In-Plane Scattering Of Nanoantenna Arrays, David Darch

Honors Capstone Projects and Theses

No abstract provided.

Combined Middle Meningeal Artery Embolisation And Subdural Evacuation Port System Drainage For Chronic Subdural Haematoma: A Systematic Review, Single-Arm Meta-Analysis, Meta-Regression, And Cost-Benefit Analysis, Shiva A. Nischal, Santosh Guru, Shaan Patel, Ashviniy Thamilmaran, Mary Murphy

Department of Neurosurgery Faculty Papers

BACKGROUND: Chronic subdural haematoma (cSDH) is an increasingly prevalent condition in older, anticoagulated, and medically frail patients, in whom recurrence and perioperative risk remain substantial despite standard surgical evacuation. Growing recognition of cSDH as an angiogenic, inflammatory disorder has prompted interest in minimally invasive strategies that combine mechanical decompression with targeted modulation of the underlying vascular pathology. This study aimed to evaluate the safety, effectiveness, and health-economic profile of combined middle meningeal artery embolisation and subdural evacuation port system (MMAE-SEPS) drainage for cSDH, compared with conventional burr-hole evacuation.

METHODS: MEDLINE, Embase, and CENTRAL were searched from inception to 24th August …

A Series Of Investigations On The L. Cornutus Host System And Bivesiculid Sp. Cercariae, Briana K. Zaffiro

All HCAS Student Capstones, Theses, and Dissertations

Rising global temperatures are likely modulating parasite-host interactions, yet the direction and magnitude of these changes remain uncertain. Rarely are these interactions viewed from both a host and parasite perspective. Using both CT_max, or Critical Thermal Maximum, and Clark-type polarographic oxygen microelectrodes, the physiological metabolic effects are investigated. CT_max is examined in Common Shiners, Luxilis cornutus, and is shown to be modulated by parasitism: uninfected fish had the highest CT_max average of 37.0°C, whereas heavily infected fish had decreased CT_max averaging 35°C. Prior to the parasite metabolic investigation, a suitable medium was determined, as …

From Invisible Injury To Measurable Impact: Exploring Associations Between Peripheral Biomarkers Of Neuroinflammation And Mental Health Outcomes After Mtbi, Lauren Leggett Smith

Psychology Theses & Dissertations

Mild traumatic brain injury (mTBI), often referred to as a “silent epidemic,” accounts for the majority of traumatic brain injuries worldwide and is increasingly linked to persistent psychiatric outcomes. Despite its prevalence, mTBI remains understudied due to diagnostic challenges, underreporting, and misperceptions of its clinical significance. The present study examined whether peripheral biomarkers of neuroinflammation and astroglial injury—tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and glial fibrillary acidic protein (GFAP)— mediate associations between mTBI history and psychiatric symptom severity, including depression, anxiety, and posttraumatic stress disorder (PTSD). Participants were 138 traumaexposed adults recruited from an urban university and surrounding community, with …

Mechanisms Of Synergy Between Nanosecond Pulsed Electric Field (Nspef) And Cold Atmospheric Pressure Plasma Discharge (Cap) In Pancreatic Cancer: The Role Of Ros-Mediated Oxidative Stress And Apoptosis, Zobia Minhas

Biomedical Sciences Theses & Dissertations

Pancreatic ductal adenocarcinoma is a highly lethal malignancy characterized by poor prognosis and resistance to conventional therapies. Novel treatment strategies are needed to overcome this resistance. Non-thermal physical modalities, including nanosecond pulsed electric field (nsPEF) and cold atmospheric pressure plasma discharge (CAP), have emerged as potential anticancer approaches; however, the mechanisms underlying their combined effects remain unclear.

This study evaluated whether nsPEF enhances CAP-induced cytotoxicity and investigated the associated molecular mechanisms using the murine Pan02 pancreatic cancer cell line. Cell viability was assessed by WST-1 metabolic activity assays and electric cell–substrate impedance sensing (ECIS). Intracellular reactive oxygen species (ROS) were …

Targeted Epigenome Sequencing Of Eosinophils Reveals Cpg Sites And Regulatory Variants Associated With Asthma., Rébecca Dionne-Gagné, Anne-Marie Madore, Anne-Marie Boucher-Lafleur, Tomi Pastinen, Catherine Laprise

Manuscripts, Articles, Book Chapters and Other Papers

Eosinophils are pro-inflammatory cells that play a central role in asthmatic inflammation. However, few studies have examined their methylation profiles in asthma, all relying on microarray-based approaches. Here, an epigenome-wide association study in 183 purified eosinophil samples from the Saguenay-Lac-Saint-Jean asthma family cohort was performed using a custom sequencing panel targeting 4,609,564 CpGs in immune regulatory regions. Two CpG sites in MAEA and SLC9A2 genes, known to be involved in immune function, were significantly associated with asthma, while five additional sites showed suggestive associations. Integration with genotype data (7,829,429 variants) and expression counts (17,513 genes) identified significant quantitative trait loci-mediated …

Promises, Pitfalls, And Paths Forward For The Pediatric Research Equity Act., Alexa L. Pagano, Danielle J. Green, Jennifer Goldman, Anjali Deshmukh

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Since its enactment in 2003, the Pediatric Research Equity Act (PREA) has significantly increased the number of pediatric drug studies performed and expanded pediatric drug labeling. Despite these advancements, many drugs used in children still lack pediatric-specific US Food and Drug Administration (FDA) labeling, even when pediatric studies are required by law. Recent legislative changes strengthened the FDA's enforcement authority over PREA. As these changes are implemented, persistent gaps in pediatric drug development warrant examination. Addressing these gaps may help ensure that children are systematically included in clinical research and that medications used in children are supported by rigorous …

Flicking Fibres: Microfibres Act As Sensory Disruptors In A Marine Crustacean, Ari Drummond, Alexander D.M. Wilson, Lucy M. Turner, Mark Briffa

School of Biological and Marine Sciences

Anthropogenic inputs to the environment—including microplastics and microfibres—are global stressors known to impair multiple facets of organismal biology. However, the effects of these pollutants on sensory structures remain critically understudied. Sensory systems mediate organism-environment interactions, and pollution-derived impairment at these interfaces may cascade through bioprocessing, from information acquisition to behaviour and ultimately fitness. Microfibres, in particular, pose an additional threat, potentially physically obstructing sensory organs and chemically interfering with sensory processes. Using an invertebrate model of sensory biology, Pagurus bernhardus, we tested whether dryer lint—a complex, heterogeneous mix of treated microplastic and cellulose fibres, and other anthropogenic contaminants—acts as a …

Visual Cues Elicit Differential Aggression Towards Female And Female Mimics In The Corkwing Wrasse, Benjamin A. Ellis, Tonje K. Sørdalen, Mark Briffa, Anne Berit Skiftesvik, Alexander D.M. Wilson, Kim A.T. Halvorsen

School of Biological and Marine Sciences

Alternative reproductive tactics (ARTs) are consistent intrasexual differences in behavior that maximize reproductive success through different means. In corkwing wrasse (Symphodus melops), smaller males mimic female visual morphology (hereafter sneakers) to steal fertilizations from nest-building parental males (hereafter nesting males). We investigated whether this visual mimicry effectively deceived 47 nesting males across 4 sites by quantifying 2 agonistic responses (attack latency and attack frequency) to models depicting unfamiliar females, sneakers and rival nesting males. Contrary to expectations, nesting males exhibited faster agonistic responses towards female models, with lower attack latencies compared with both male types. Additionally, the relationship between model …

A Covalent Allosteric Molecular Glue Suppresses Nrf2-Dependent Cancer Growth, Nilotpal Roy, Ilah Bok, Harit Panda, Dhaval P Bhatt, Emily M Wilkerson, Soma Saeidi, Paul Zolkind, Michael B Major, Et Al.

2020-Current year OA Pubs

UNLABELLED: The NRF2 transcription factor is constitutively active in cancer, in which it functions to maintain oxidative homeostasis and reprogram cellular metabolism. NRF2-active tumors exhibit NRF2 dependency and resistance to chemotherapy/radiotherapy (RT). In this study, we characterize VVD-065, a first-in-class NRF2 inhibitor that acts via an unprecedented allosteric molecular glue mechanism. In the absence of stress or mutation, NRF2 is rapidly degraded by the Kelch-like ECH-associated protein 1 (KEAP1)-cullin3 (CUL3) ubiquitin-ligase complex. VVD-065 specifically and covalently engages Cys151 on KEAP1, which in turn promotes KEAP1-CUL3 complex formation, leading to enhancement of NRF2 degradation. Previously reported Cys151-directed compounds decrease KEAP1-CUL3 interactions …

Minimizing Musculoskeletal Injury Risk In Health Care Professionals With Education On Physical Activity Recommendations, Emma H. Foran

Honors College Theses

Working in healthcare settings that require patient handling is physically demanding - over 80% of providers involved in patient handling report work-related musculoskeletal disorders (WMSDs). Injuries or exacerbation of a previous injury may occur if the individual cannot tolerate heavy workloads. Injuries that cause lost work time or work restrictions impact the healthcare team, may alter quality of life, and impact employee income. A practical way to minimize these effects is to prevent WMSDs. Training providers to use proper body mechanics, practice patient handling, and engage in regular exercise designed to increase muscular strength and endurance through resistance training improves …

Perfectionism And Cognitive Flexibility: Comparing The Impacts Of Perfectionism Vs Excellencism On Cognitive Flexibility, Lillian R. Blackburn

Honors College Theses

Perfectionism is often defined as “high standards of performance which are accompanied by tendencies for overly critical evaluations of one’s own behavior” (Frost et al., 1990, p. 450). Although striving for high standards is characteristic of perfectionism, it is also a central concept of the construct of excellencism, that is striving for standards that are both high and attainable. Research has made a distinction between the pursuit of perfection and pursuit of excellence, suggesting perfectionists strive for high unattainable standards, whereas excellencists strive for high yet reasonable standards with more areas of flexibility (Gaudreau et al., 2022).  These differences have …

Why Followership Matters In Psychiatry: Rebalancing Our Obsession With Leadership, Rohit Shankar, Richard Laugharne, Regi Alexander, Kenneth R. Kaufman, Derek K. Tracy, Fabida Aria, Mayura Deshpande, Matthew Frost

Peninsula Medical School

SummaryPsychiatry emphasises leadership development, but neglects the equally universal and essential role of followership. Although most clinicians spend more time as followers than leaders, literature overwhelmingly favours leadership. Drawing on healthcare, socio-religious traditions and management science, the authors reframe followership as an active, values-driven role grounded in trust, motivation and moral courage rather than passive compliance. This editorial argues that effective followership is active, ethical and courageous. Nurturing good followers in mental health services is essential for good patient care, organisational integrity and sustainable leadership. Cultivating active followership strengthens safeguarding, transparency and organisational legitimacy. The editorial calls for psychiatry and …

Project Foresight Annual Report, 2024-2025, Paul J. Speaker

Faculty & Staff Scholarship

Project FORESIGHT is a business-guided self-evaluation of forensic science laboratories across the globe. The participating laboratories represent local, regional, state, and national agencies. Economics, accounting, finance, and forensic faculty provide assistance, guidance, and analysis. Laboratories participating in Project FORESIGHT have developed standardized definitions for metrics to evaluate work processes, linking financial information to work tasks and functions. Laboratory managers can then assess resource allocations, efficiencies, and value of services—the mission of Project FORESIGHT is to measure, preserve what works, and change what does not.

The benchmark data for the 2024-2025 performance period includes laboratory submissions for a variety of fiscal …

Design Of A Nuclear Power System For A Lunar Base, Haleigh Wagner, Emma Sprague, Liam Donnelly, Anthony Nardolillo, Samantha Vallance, Alex Sawyer

Mechanical Engineering Capstone Design Projects

This Senior Capstone project concerns the design and development of a compact fission reactor intended to provide continuous electrical power for a lunar base. The system needed to supply enough energy to support habitat life support systems, scientific operations, surface mobility, and resource processing equipment, while remaining highly reliable, minimally maintained, and easily integrated into a module’s lunar power grid. Early research was conducted into NASA’s Artemis program, prior fission surface concepts such as KRUSTY, and estimated power demands for lunar infrastructure resulted in the following design requirements:

1. 10 to 50 kWe of continuous power (31.2 kWe achieved)
2. Operational lifespace …

Effects Of Tourist Feeding On The Gut Microbiome And Ecophysiology Of Endangered Northern Bahamian Rock Iguana (Cyclura Cychlura), Erin Lucy Lewis

All Graduate Theses and Dissertations, Fall 2023 to Present

The lifespan and reproduction of an animal depends on maintaining a healthy physiology. The proportion of individuals that survive to an age at which procreation can occur is important to long-term stability of populations and contributes to species survival. Health in an animal is measured in a variety of ways, including through monitoring of the body’s physiological systems, as well as its ability to respond to invading pathogens, and through the different types of bacteria present in the gut. Relationships among those different health metrics have been discovered in recent years and have been found to play important roles in …

Constraint-Aware Metaheuristic Optimization For Experimental Design, Benjamin N. Fuller

All Graduate Theses and Dissertations, Fall 2023 to Present

Designing experiments becomes much more challenging when many variables and strict constraints are involved, as is common in modern science and engineering. This thesis introduces a new computational and mathematical framework that efficiently searches for optimal experiments in complex, high-dimensional spaces where traditional methods fail. By combining geometric techniques with flexible optimization algorithms like particle swarm optimization, our methods handle difficult constraints while scaling to real-world problems. Built in the high-performance Julia programming language and released as open-source software, this work bridges advanced theory with practical tools, offering researchers a powerful and accessible way to design better experiments under realistic …

Effects Of Beaver Dams On Components Of Riverscape Health And Biodiversity In The Great Basin, Cashe C. Rasmussen

All Graduate Theses and Dissertations, Fall 2023 to Present

Networks of rivers and their floodplains (i.e., low-lying areas adjacent to rivers and streams that could plausibly flood) have been degraded, reducing the availability of freshwater and habitat for people and wildlife. Therefore, land managers are pursuing cost-effective restoration strategies, including partnering with beavers (Castor canadensis), to promote the health of these ecosystems and associated benefits. However, our understanding of beaver-mediated restoration benefits remains incomplete. Here, we compared locations along streams with and without beaver dams to measure the benefits of beavers in the Great Basin of the Western United States. We measured the effects of beaver dams …

Investigating Utah's Watershed Restoration Initiative: A Qualitative Case Study Of A State-Managed Collaborative Platform, Casey Trout

All Graduate Theses and Dissertations, Fall 2023 to Present

Collaboration is necessary to address complex, cross-jurisdictional natural resource problems. To better understand the benefits and drawbacks of innovative collaborative structures, this research examined the Utah Watershed Restoration Initiative (WRI). WRI is a state-managed program in Utah that implements cross-boundary habitat restoration projects. Local, state, and federal government agencies as well as non-profit organizations convene on five regional teams to design and evaluate projects. Project partners are engaged at a local level while most program administration occurs at the state level. A case study of WRI was conducted, making use of interviews with 33 participants, document review, and field observations. …