Digital Commons Network^™

Seasonal Body Composition And Neuromuscular Changes In High School Wrestlers: Medicine Balls For Fatigue Testing, Courtney Mccall Condie Carroll

All Graduate Reports and Creative Projects, Fall 2023 to Present

This study examines the effects a single wrestling season has on high school athletes’ body composition, muscle quality, membrane capacitance, and neuromuscular performance, and whether instrumented medicine balls are sensitive enough to serve as a field test for chronic fatigue. Twenty-five high school wrestlers (males=18, females=7) were recruited and assessed pre-season (Pre), mid-season (Mid), and end-of-season (Post). Outcome measures included body mass, fat-free mass, fat mass (via bioelectrical impedance spectroscopy), echo intensity (EI, via B-mode ultrasound) of the vastus lateralis (VL) and biceps brachii (BB), and countermovement rotational and backward-overhead throws with medicine balls instrumented with accelerometers.  Repeated measures ANOVA …

Long Term Changes In Elk Group Size And Composition (2002-2023) In Relation To Wolf Hunting Sucess, Kennedy Price

Undergraduate Honors Capstone Projects

Elk (Cervus elaphus) in Yellowstone National Park exist within a predator-prey system shaped by long-term interactions with wolves (Canis lupus). This predator-prey system represents an important model for understanding how predation influences ungulate behavior and social organization. Predators affect prey behavior through direct and indirect interactions and may cause long-term changes. What this study strives to answer is if predator success can have long term effects on prey grouping behavior and age-sex structure. In a previous study, wolves were found to be most successful hunting medium sized group of elk (20-49 individuals) in Yellowstone National Park. …

Utilizing Pine Needles To Compare Spatial Profiles Of Polycyclic Aromatic Hydrocarbons (Pahs) In Two Urban Areas, Autumn Jensen

Undergraduate Honors Capstone Projects

Polycyclic aromatic hydrocarbons (PAHs) are an important class of semivolatile air pollutants known for their adverse health impacts. This research used conifer needles as passive air samplers to create spatial maps of two Utah cities (Rose Park and Spanish Fork) to compare overall PAH exposure and identify any differences in their congener profiles or PAH “fingerprints”. Conifer needles were chosen due to their prevalence as a passive air sampler in previous research and their ubiquity in urban and suburban environments. Second year needles were collected and the concentrations are considered to be an annually averaged view of the PAH concentrations …

Ihelp Foundation 2025 Uganda Medical Mission, Kade Spencer Robison

Undergraduate Honors Capstone Projects

Uganda faces significant barriers to health care access, particularly in rural communities, due to physician shortages and limited resources. As a result, care is concentrated in urban areas, leaving rural populations disproportionately affected by both communicable and noncommunicable diseases.

This Honors Capstone project focused on preparing for and supporting the iHelp Foundation’s 2025 Uganda Medical Mission. The iHelp Foundation works to reduce barriers to care in Uganda by partnering with local hospitals to provide short-term rural clinics and specialized surgical care for advanced otolaryngological conditions.

In this project, I contributed to mission preparation by training volunteers and coordinating physician licensing. …

Understanding Vaccine Hesitancy In Veterinary Medicine: A Review Of Client Attitudes, Grace Moore

Undergraduate Honors Capstone Projects

Uncertainty toward vaccination, long recognized as a public health concern in human medicine, is increasingly recognized within veterinary contexts, posing risks to both animal and community health. This literature review examines the development, causes, and implications of reduced vaccine confidence in veterinary medicine, with emphasis on small animal and some large animal practices. The review combines historical and current research to explore how vaccination perceptions have evolved among veterinarians and clients, and how factors such as the COVID-19 pandemic have shaped current attitudes.

The literature highlights recurring themes surrounding vaccine reluctance in veterinary settings. Client perceptions of safety, efficacy, and …

Behind The Smile: A Qualitative Study On Dentist Burnout And Workplace Satisfaction In Cache Valley, Luke Thomas Hatch

Undergraduate Honors Capstone Projects

This qualitative research study examined satisfaction, stressors, and burnout among dental professionals in Cache Valley, Utah. Eight practitioners at various points in their careers were interviewed with a range of specialties including general dentistry (n = 3), pedodontics (n = 3), oral and facial surgery (n = 1), and orthodontics (n = 1). Analysis of the interviews showed that level of clinical autonomy was a primary factor influencing burnout levels. Stress levels in more experienced practitioners and owners tended to be lower than those who worked in multiple practices (multi-doctor) or with corporations. Individuals in these environments reported higher levels …

Exploring The Experiences Of Adult Children Of Parents With Addiction: A Qualitative Support Group Approach, Brooke Stanton

Undergraduate Honors Capstone Projects

Adult children of parents with addiction often grow up having to navigate emotional instability, inconsistent caregiving, and long-term relational impacts that continue into adulthood. Many individuals report limited access to supportive care and spaces where they can share their stories. This capstone project addresses the gap by designing and facilitating a support group specifically for adult children of parents to build connection and healing. Through this qualitative study, participant feedback, and analysis, this project examines how structured peer support can create meaningful change for this population. The following paper outlines the development of the group, the theoretical foundations that guided …

Assessing The Use Of Exon-Skipping Morpholino Antisense Oligonucleotides Targeting The Different Sumo Paralogs As Enhancers Of The Antitumor Activity Of Chemotherapeutic Agents, Andrea Teresa Garcia-Morin

Open Access Theses & Dissertations

Post-translational modifications (PTMs) are critical regulators of protein function, stability, and localization, with SUMOylation emerging as a key modulator of cellular stress response and survival in cancer. Non-small cell lung cancer (NSCLC) is characterized by heightened dependence on SUMOylation to sustain pro-survival signaling, DNA repair, and resistance to chemotherapy. This dissertation investigates a novel chemosensitization strategy based on the splice-switching of SUMO transcripts in NSCLC cells using exon-skipping morpholinos (ESMs), which redirect splicing toward non-conjugatable SUMO alpha isoforms, thereby reducing global SUMOylation. We hypothesized that decreasing global SUMOylation through forced alternative splicing of SUMO transcripts would impair the stress-protective functions …

Application Of Path Analysis To Determine The Impact Of Age And Sex On The Neural Circuits That Promote Nicotine Withdrawal Severity, Veronika Espinoza

Open Access Theses & Dissertations

The rising prevalence of electronic cigarette (e-cigarette) use presents a major public health concern, particularly in adolescent females who are most susceptible to nicotine use and its long-term negative health consequences. The goal of this dissertation was to utilize preclinical rodent models to understand how group differences in age and sex influence neural activation patterns in brain circuits believed to promote nicotine withdrawal. Prior pre-clinical work, conducted largely in male rodents, has established that there are two major brain pathways that modulate the behavioral effects of nicotine withdrawal. These include the mesolimbic and medial habenula-interpeduncular nucleus (MHb-IPN) pathways. To assess …

Prediabetes Prediction Before Disease Onset Using Multimodal Health Data: A Machine Learning Approach, Luisa Veronica Gracia Mazuca

Open Access Theses & Dissertations

Prediabetes is a critical health condition that increases the risk of developing type 2 diabetes. The hemoglobin A1c (HbA1c) test diagnoses patients with prediabetes, but the disease has already caused metabolic alterations. Early detection is essential for timely interventions, and machine learning models offer a promising approach to identify prediabetic individuals through the analysis of biomarkers such as cytokines. We compared four classifiers-logistic regression, decision tree, random forest, and k-nearest neighbors - using cytokines (TNF-α, MCP-1, IL-1β, IL-6, IFN-γ), age, BMI, and waist-to-hip ratio (WHR). Models were evaluated using stratified 5-fold cross-validation and ROC-AUC. K-Nearest Neighbors (k-NN) achieved the highest …

Exploratory Proxy Occupational Health Risk Assessment On Pm2.5 Exposure Among Outdoor Personnel At International Ports Of Entry, Josdell Maria Guerra Ruiz

Open Access Theses & Dissertations

Despite growing public health concerns on PM2.5 exposure and its respiratory health effects, no documented evidence has been found on the application of proxy methods to perform occupational health risk assessments for PM2.5 exposure among outdoor personnel. The purpose of this research study was to conduct a descriptive and predictive occupational health risk assessment for cancer and non-cancer respiratory health outcomes related to PM2.5 exposure among outdoor personnel at targeted international ports of entry (IPOE). A total of 61 samples were collected, for 24 hours, at two targeted IPOEs (every sixth day) over 12-month period. Samples included measurements on PM2.5 …

Numerical Methods For Modeling Darcy-Forchheimer Flow In Heterogeneous Porous Media, Nate Mcnair

Open Access Theses & Dissertations

Classic approaches to modeling fluid flow in porous media rely on Darcy's Law, which assumes a linear relationship between volumetric flow rate and the pressure gradient. However, in recent years, applications such as enhanced geothermal systems have highlighted the need to model nonlinear flow behavior, since experimental and observational data show that, once flow velocity exceeds a certain threshold, the relationship between velocity and macroscopic pressure gradient becomes nonlinear. This requires alternative models that more accurately capture the physical behavior of these systems.The Darcy-Forchheimer model provides one such alternative by introducing a nonlinear velocity-pressure relationship. However, this nonlinearity creates additional …

The Outcome Of Falling, Nia Simone Mccray

Open Access Theses & Dissertations

The following thesis project is an erotic romance novel, accompanied by a critical essay on it. This project follows the journey of Zane and Adeena as they navigate the enlightening experience of falling in love. Love is not easy - it challenges the characters to inwardly and outwardly reflect on who they are as people and how they live their lives. In the novel, it is seen how Zane and Adeena's connection brings pleasure and catalytic change to themselves. The preface is a critical and aesthetic-based discussion on how the novel came to fruition. The essay includes discussion on the …

Design And Optimization Of Peptide Inhibitors Targeting Kinesin: Molecular Modeling Studies And Virtual Screening For Therapeutic Candidate Development, Maraf Mbah Bake

Open Access Theses & Dissertations

Kinesins are ATP-driven molecular motors essential for intracellular transport and mitotic spindle assembly, and their mechanochemical behavior has been extensively characterized through computational tools. The first project reviews decades of advances in molecular dynamic simulations, including all-atom and coarse-grained molecular dynamics, Markov state models, Brownian dynamics, and free-energy approaches, which have collectively deepened our understanding of conformational transitions, microtubule-binding interfaces, and ligand interactions, especially for the mitotic motor Eg5. The second review examines the rapid emergence of quantum computing as a transformative technology for drug discovery, highlighting key historical milestones, recent progress in hybrid quantum-classical algorithms, quantum-enhanced docking, and quantum …

Process Optimization Of Directed Energy Deposition Via Dmaic Methodology And Lean Manufacturing Principles, Erick Gerardo Molina Castaneda

Open Access Theses & Dissertations

Additive Manufacturing (AM), particularly Direct Energy Deposition (DED), has gained increasing relevance in industrial and research environments due to its capability to manufacture complex geometries and repair high-value components. However, despite its technological advantages, DED processes often lack standardization, clear documentation, and structured workflows, especially in academic laboratories. This research aims to optimize and standardize DED processes through the application of Lean Manufacturing principles using the DMAIC (Define, Measure, Analyze, Improve, Control) methodology. The study was conducted at the Keck Center for 3D Innovation, focusing on pre-printing and printing activities. Key issues were identified. Improvement actions included the implementation of …

Novel Roles Of G-Beta-Gamma Signaling In Microtubule Dynamics And Neurodegeneration, Diana I. Olivas

Open Access Theses & Dissertations

Neurodegenerative disorders (NDDs), including Alzheimer's disease (AD), are characterized by progressive neuronal dysfunction, cytoskeletal disruption, and cognitive decline. Although Tau hyperphosphorylation and neurofibrillary tangle (NFT) formation are classical hallmarks of AD, emerging evidence suggests that microtubule (MT) dysfunction may precede and occur independently of Tau pathology. Understanding upstream regulators of MT dynamics is therefore critical for elucidating early mechanisms of neurodegeneration. Previous work from our laboratory demonstrated that G protein βγ (Gβγ) subunits directly interact with tubulin and promote MT assembly. However, the mechanism of Gβγ signaling in neuronal cytoskeletal stability and neurodegeneration remained poorly understood. The present study investigated …

Contamination-Aware Boosting For Cancer Prediction, Francis Opoku

Open Access Theses & Dissertations

Modern cancer research increasingly relies on machine learning methods to model complex relationships between high-dimensional genomic predictors and clinically relevant outcomes. Gradient boosting methods, particularly XGBoost, have become widely used due to their strong predictive performance and ability to capture nonlinear effects and interactions. However, these methods are sensitive to contamination in the data, especially in the response variable, where even a small fraction of aberrant observations can disproportionately influence model fitting and degrade generalization.

In this thesis, we propose a contamination-aware extension of XGBoost, termed CA-XGBoost, which improves robustness by explicitly modeling residuals through a latent mixture framework. This …

Drug Repurposing Against Giardia Targeting Lipid Rafts, Extracellular Vesicles, And Sphingolipid Synthesis, Breanna Chantal Pence

Open Access Theses & Dissertations

Giardia lamblia is a protozoan parasite responsible for the intestinal disease giardiasis worldwide. Giardia is one of the major intestinal parasites in the world, with over 500,000 new cases annually. Symptoms of giardiasis include diarrhea, abdominal pain, and nausea. Children are particularly vulnerable to giardiasis, with cases of malnutrition, stunted growth, and cognitive impairment in countries where the disease is endemic. Giardia consists of two morphologic forms: an infective cyst which transmits the disease and a motile trophozoite which attaches to the epithelium of the small intestine during infection. Metronidazole is a common treatment for giardiasis, but cases of toxicity …

Caregiver Experiences During Mealtime In Families Of Children With Feeding Disorders In The Borderland, Chyanne Reveles

Open Access Theses & Dissertations

This study examines the lived experiences of caregivers of children with pediatric feeding disorders (PFDs) in the Paso del Norte Region using interpretative phenomenological analysis (IPA). Pediatric feeding disorders require sustained medical, social, and emotional demand, often placing caregivers in complex decision-making roles. Understanding how cultural beliefs and context shape caregiving practices is essential to improving services provided by speech-language pathologists and other service providers. The qualitative research approach used facilitated the discovery of themes surrounding the lived experience of the caregivers of children with feeding disorders. Semi-structured interviews were conducted via Zoom with caregivers residing in the U.S.-Mexico border …

Katie In-Between, Savannah Rae Sarabia

Open Access Theses & Dissertations

Katie In-Between is a contemporary young-adult fiction piece that follows the protagonist Katie as she learns about and reclaims her cultural identity. In her process, she learns the importance of embracing her identity, which refutes biases and ideals about who is and who is not part of her community. This story draws on personal experience navigating cultural identity and confronting histories and events that suppress that minority community's expression in American society. Through narration, poetry, and journal entries, readers are exposed to the confrontation of languages and histories to support ideas such as Gloria Anzaldúa's concept of nepantla, which refutes …

Determining Zap-70 Signaling Pathways Mediated By Ccr7 In Tcr T Cell Activation, Vivian Torres

Open Access Theses & Dissertations

Activation of T lymphocytes is the main event that occurs in the adaptive immune response after engagement of the T cell receptor (TCR) with the peptide of the major histocompatibility complex (pMHC) molecules that are demonstrated by antigen presenting cells [1]. A key step in this process is the recruitment and activation of the zeta chain associated protein of 70 kDa (ZAP-70). ZAP-70 couples TCR engagement to downstream intracellular signaling pathways through phosphorylation of tyrosine residues within intracellular tyrosine activation motifs (ITAMs) [2]. Although there have been extensive studies on the signaling response through TCR activation, the regulatory influence of …

Understanding Gambling Behavior Among Hispanic College Students: The Role Of Attitudes, Norms, Self-Efficacy, And Acculturation, Joshua Torres

Open Access Theses & Dissertations

Gambling has become increasingly accessible and socially normalized among young adults, particularly through mobile platforms and the expansion of legalized sports betting. Hispanic college students may be at heightened risk for gambling-related harms, given evidence of elevated rates of problem gambling, comorbid mental health concerns, and underrepresentation in empirical research. Cultural factors, such as acculturation, may further influence engagement in gambling behaviors and susceptibility to negative outcomes. Guided by the Theory of Planned Behavior, the present study investigated the relationships between gambling injunctive norms, gambling attitudes, and gambling self-efficacy across three outcomes: gambling frequency, problem gambling severity, and gambling intention. …

From Soils To Plants And Back Again: The Effects Of Small Mammals On Arctic Ecosystem Processes, Andrew Uccello

Open Access Theses & Dissertations

Herbivores are essential drivers of above and belowground processes in ecosystems across the globe. Through their effects on ecosystem processes, herbivores represent a critical force shaping ecosystems undergoing rapid environmental changes, such as the Arctic. However, there are critical gaps in our knowledge of herbivores as drivers of Arctic ecosystem processes, especially concerning the role of small mammal herbivores. While previous research has made significant strides in identifying the role of small mammal herbivores as both top down and bottom up forces in Arctic ecosystems, we still lack an understanding that explicitly connects plant and soil responses to herbivory, especially …

Penalty Approach To Constrained Optimization Problems In Water Reservoir And Energy Generation Management, Edwin Horacio Trejo

Open Access Theses & Dissertations

The growing demand for resilient and sustainable energy generation has driven interest in Hybrid Floating Photovoltaic-Hydropower (HFPVH) systems. Operating these systems effectively requires making water release decisions that satisfy physical and regulatory constraints while maximizing energy production. Prior work by Vega (2024) developed a Dynamic Outlier Filter Long Short-Term Memory (DOF-LSTM) architecture for forecasting reservoir release patterns. That predictive work is valid and addresses an important component of the HFPVH decision pipeline. However, the constraint system in that work operates externally to the learning process, and the behavior of penalty-based constraint enforcement had not been studied independently in this context. …

Molecular Mechanisms Of Pfas Induced Protein Dysfunction: Implications For Neurodegenerative Risk, Daisy Lee Wilson

Open Access Theses & Dissertations

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with widespread human exposure and well-established links to adverse health outcomes. However, despite increasing epidemiological and experimental evidence, the molecular mechanisms underlying PFAS-induced neurotoxicity remain incompletely defined. This dissertation investigates PFAS toxicity across biological scales, integrating protein biophysics with neuronal cell models to elucidate pathways relevant to neurodegeneration. At the molecular level, we demonstrate that PFAS disrupts the structure and function of globular proteins, including the impairment of α-lactalbumin's calcium-binding capacity and of β-lactoglobulin's retinol binding, through concentration-dependent conformational destabilization. By applying these findings to a neuronal model, we show that …

Comparative Case Studies Of How General Chemistry Ii Students Explain Entropically-Driven Phenomena, Raymundo Aragonez

Open Access Theses & Dissertations

Understanding how students conceptualize entropy remains a central challenge in chemistry education. Often referred to as a "driving force" of chemical reactions, the dispersal of energy as a process proceeds is indicative of a process's spontaneity or thermodynamic favorability. Students frequently default to discussing phenomena in deterministic terms, potentially reflecting the language choice and heuristics selected by the instructor such as "disorder". In this study, assessment prompts about entropy from a convenience sample of general chemistry textbooks were characterized as to their potential to elicit three-dimensional learning, and students' responses to assessment prompts from a curriculum aligned with three-dimensional learning …

Computational Studies Of Dna-Wrapped Carbon Nanotubes: From Enantioselective Dna Binding To Molecular Recognition Of Small-Molecule Analytes, Sayantani Chakraborty

Open Access Theses & Dissertations

Single-walled carbon nanotubes (SWCNTs) exhibit chirality-dependent optoelectronic properties and near-infrared fluorescence that make them promising platforms for biosensing. When functionalized with single-stranded DNA (ssDNA), SWCNTs form conjugates capable of selective molecular recognition. However, the molecular mechanisms governing chirality recognition and analyte-induced optical modulation remain incompletely understood. This dissertation investigates these mechanisms through an integrated computational approach combining molecular dynamics simulations, enhanced sampling techniques, and machine learning. First, atomistic molecular dynamics (MD) and replica exchange MD simulations were used to investigate how short ssDNA sequences interact with enantiomers of (7,5) SWCNTs. Analyses of base stacking, nucleotide orientation, sugar-phosphate positioning, and contact …

From Covid-19 To Influenza: Transforming Public Health Surveillance Through Freeze-Drying Innovations, Rui Dong

Open Access Theses & Dissertations

Public health surveillance increasingly relies on wastewater-based epidemiology (WBE) as a non-invasive, community-level early warning system for infectious diseases like COVID-19 and influenza. However, detecting minute viral concentrations in complex wastewater matrices remains a significant analytical challenge. Traditional concentrating methods, such as ultrafiltration, are limited by high performance variability and significant viral signal loss due to necessary pretreatment steps, such as pre-clarification, which inadvertently discard solid-associated viral fractions. To address these limitations, this dissertation introduces and evaluates freeze-drying as a novel, pretreatment-free concentrating method for wastewater viral surveillance. By sublimating water, freeze-drying uniquely retains both liquid and solid-phase viruses within …

The Impact Of Life Coaching On Self-Efficacy In Personal Goal Setting Among Black Educators In Arkansas, Veronica Cousette Jackson

Graduate Theses and Dissertations

This quantitative study examines the relationship between life coaching and self-efficacy in personal goal setting among Black educators in Arkansas, with gender explored as a moderating variable. Self-efficacy, grounded in Bandura’s (1997) social cognitive theory, is a central determinant of motivation and goal-directed behavior, influencing persistence, effort, and adaptive strategies. Although life coaching has gained recognition as a professional developmental practice, empirical research remains limited regarding its psychological effects within educator populations and its differential impact across demographic groups (Grant, 2014; Theeboom et al., 2014). This gap is particularly significant for Black educators, who experience disproportionate workforce stress and retention …

Impaired Tunability Of Brain State And Motor Dysfunction In A Mouse Model Of Rett Syndrome, Victoria Kindler Norman

Graduate Theses and Dissertations

Rett syndrome (RTT) is a rare neurological disorder, caused by disrupted function of the MECP2 gene, resulting in impaired cognitive and motor functions. Previous studies suggest that although MECP2 has important functions throughout the body, the etiological origins of RTT-related dysfunction should be sought within the brain. However, it remains a mystery how neural population dynamics are altered in the RTT brain and how these alterations relate to motor dysfunction. Previous studies using an RTT mouse model point to abnormal correlations among firing rates of neurons. Here we hypothesize that such disrupted neural activity correlation could be caused by abnormal …