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In Silico Prediction Of Cd8+ T-Cell Multi-Epitopes And Hla Distribution Analysis For Muc13: An Onco-Vaccine Design Strategy, Abigail Gomez, John Mills, Aidan Mata, Anupam Dhasmana, Swati Dhasmana, Sheema Khan, Murali Yallapu, Subhash Chauhan

Research Symposium

Background: Mucin 13 (MUC13), a transmembrane glycoprotein, plays a crucial role in the progression of epithelial cancers, particularly liver and pancreatic cancers. It is frequently overexpressed in malignant cells, disrupting cellular adhesion and facilitating invasive behavior. The extracellular domain and phosphorylation potential in its cytoplasmic region connect MUC13 to oncogenic signaling pathways, making it a valuable target for immunotherapy. However, challenges such as the immunosuppressive tumor microenvironment remain significant obstacles, and addressing these issues in the lab is challenging without computational intervention. To address this, we have employed an in-silico approach to design CD8+ T-cell multi-epitopes targeting MUC13 HLA class …

The Caldwell Medical‑Impact Roadmap V1.0, Michael Victor Caldwell Mr.

Defensive Publications Series

Purpose of this roadmap, over the past year, more than 100 open‑hardware inventions have been released by Michael Victor Caldwell on the Technical Disclosure Commons (TDC). These inventions span acoustics, microfluidics, vortex systems, cavitation reactors, extracorporeal blood conditioning, neuromodulation, water purification, atmospheric water harvesting, and more.

Because the portfolio is large and multidisciplinary, this roadmap provides:

• A ranked list of the inventions most relevant to medical, biological, and vaccine‑related research

• A cross‑linked guide so researchers can quickly find the inventions connected to their field

• A conceptual mapping of how these inventions may support ongoing global health challenges

• A non‑patented, open‑access …

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Treatment Providers’ Perspectives On Reintegration Of African American Registered Sex Offenders With Intellectual Disabilities, Laneka Sherelle Smith

Walden Dissertations and Doctoral Studies

No abstract provided.

Traveling Wave Fronts For Sir Epidemic Models With Nonlocal Dispersal And Delayed Effects, Ashley Evette Embry

Theses and Dissertations

This dissertation investigates traveling wave solutions for two classes of delayed nonlocal dispersal susceptible--infected--recovered (SIR) epidemic models incorporating biologically realistic mechanisms such as delayed infectivity, delayed dispersal, nonlocal transmission, demographic turnover, and nonlinear incidence effects. These models extend classical spatial epidemic frameworks by allowing long-range population movement through nonlocal dispersal operators and incorporating temporal memory into both diffusion and transmission processes. The primary objective is to establish the existence of traveling wave solutions connecting disease-free equilibria to endemic states and to characterize threshold conditions governing epidemic propagation. The simultaneous presence of nonlocal dispersal, multiple delays, and non-monotone nonlinear incidence terms …

Implementation Of A Provider-Focused Multimodal Educational Initiative To Address Polypharmacy And High-Risk Medication Use In A Home And Community Medicare Advantage Setting, Jennifer Butler-Rickard, Kellie Olsen, Eileen Stuart-Shor, Craig Drew

Doctor of Nursing Practice Scholarly Projects

BACKGROUND: Community-dwelling adults are at risk for adverse drug events such as falls, hospitalizations, cognitive decline, drug-to-drug interactions, and mortality related to high-risk medication use and polypharmacy, often defined as concurrent use of five or more different medications. Lack of provider knowledge of polypharmacy and high-risk medication use as well as suboptimal communication with primary care providers can lead to gaps in medication management in this vulnerable population.

LOCAL PROBLEM: Patients seen by the Comprehensive Annual Health Assessment Program advanced practice clinicians (APCs) at the project Medicare Advantage insurer organization often experience polypharmacy. Given the lack of provider knowledge of …

Increased Neural Activity In The Bed Nucleus Of The Stria Terminalis Of Uninfected Canaries After Observation Of Infected Conspecifics, Madeleine Chang, Sophia Santangelo, Devon Comito, Bennett Hardy, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Recent evidence suggests that the immune system may be upregulated in anticipation of pathogen exposure, yet the neural mechanisms that respond to and signal impending infection risk remain poorly understood. We investigated neural responses to infection risk in uninfected hosts observing infected conspecifics, using the canary (Serinus canaria domestica)—Mycoplasma gallisepticum host–parasite system. We focused on five brain regions of interest, comprising three nodes of the social decision-making network—preoptic area, bed nucleus of the stria terminalis (BNST) and hippocampus—a stress modulatory region (paraventricular nucleus) and a visual processing region (nucleus rotundus). After 1 h of observing infected canaries, …

Intersectionality And Insurgent Citizenship: Women Of Color Feminism In 1970s New York City, Genevieve Bonner Davis

Dissertations and Theses

Not since the phrase "Ain't I a Woman" has African American women's intellectual leadership and insight been as visible and influential as the contemporary concept of intersectionality. Like Sojourner Truth's iconic intellectual intervention in the anti-slavery movement, intersectionality has experienced a similar trajectory of dissolution, distortion, appropriation, and popularization. Since its articulation by Black legal scholar Kimberlé Crenshaw in 1989, intersectionality theory has had a bumpy road to its buzzy, if controversial, status in the firmament of twenty-first-century political thought.

This thesis traces the origins of intersectionality theory through three distinct but intertwined phases. Phase one is the genealogy of …

When To Refer: Pediatric Asthma Red Flags Every Hospitalist Should Know, Sarah Gubara, Jade B. Tam-Williams

Pediatrics in Practice: A CME Podcast

A concise clinical primer for hospitalists on historical and exam findings that should trigger allergy, immunology, or pulmonology referral — from failure to thrive to recurring ICU admissions. Practical, hospital-ready guidance for timely escalation and improved outcomes.

Click here to stream the podcast episode.

Environmental And Pharmacological Modulation Of Opioid-Mediated Behavioral Effects In Rats, Corinne Ann Gallagher

Theses and Dissertations

Opioid Use Disorder (OUD) and opioid-associated overdoses continue to pose significant burden to US healthcare systems—both financially and in lives lost. It is imperative to identify risk factors which may predispose vulnerability to OUD development, which could aid in discovery of new therapeutic strategies for susceptible populations. This dissertation investigated the impacts of two such risk factors which modulate opioid-induced reward and behavioral effects: adolescent stress and the adulteration of illicit opioids by xylazine. In Chapter 2, we examined the effects of acute adolescent stress on oxycodone self-administration in rats, and the potential involvement of the locus coeruleus in these …

Evaluating Soil Health And Crop Yield In Louisiana Agricultural Systems: Impacts Of Best Management Practices And Prediction Models, Hector J. Mendoza Lagos

LSU Doctoral Dissertations

The adoption of conservation management practices is critical for improving soil health, enhancing nutrient use efficiency, and sustaining crop productivity in row crop systems in Louisiana. This study evaluated the role of conservation agronomic practices, soil biochemical indicators, and machine learning predictive models to improve soil nutrient dynamics, soil health indicators, microbial communities (MC), and crop productivity on a corn (Zea mays L.) research plot scale and in a commercial forty-hectare cotton (Gassypium hirsutum L.)-corn-soybean (Glycine max L.) rotation system in northeast Louisiana. The objectives of the study were to evaluate soil nutrient dynamics and MCs under …

Investigating The Moderating Roles Of Adolescent Peer Relationship Difficulties And Prosocial Behavior On The Relationship Between Triangulation And Adolescent Emotional Symptoms During Parental Divorce, Taylor Kalei Demotta

Clinical Psychology Dissertations

The divorce process is a stressful, transitional period that is widely experienced by families in the United States. This process incites a variety of stressors and deleterious family dynamics that impact children and adolescents. The divorce literature has identified parental conflict as a significant contributor to youth outcomes following divorce. Therefore, researchers have aimed to investigate the specific dynamics occurring during interparental discord that may influence youth. Triangulation, or the involvement of children in parental disagreements, has been found to mediate the relationship between parental conflict and adolescents’ internalizing symptoms. Adolescents may be particularly vulnerable to triangulation due to increases …

A New Visual Index For Assessing Zooplankton Biomass And Its Utility In Assessing Prey Availability For Megaplanktivores’, Hannah Moloney, Asia O. Armstrong, Guy M.W. Stevens, Christine L. Dudgeon, Joanna Harris, Kathy A. Townsend, Anthony J. Richardson

School of Biological and Marine Sciences

Zooplankton are vital links in marine food webs, yet their biomass remains challenging to quantify across broad spatial and temporal scales.This study introduces the Zooplankton Visual Index–a simple, rapid and scalable semi-quantitative method for evaluating zooplankton biomassthrough underwater observations. Following the establishment of a standardized protocol, validation against in situ net samples demonstratedthat indexlevels increased consistently with measured biomass and predictable shifts in community composition. We then applied the validatedindexto a 9-year dataset of reef manta ray (Mobula alfredi) sightings in the Maldives. Increased M. alfredi abundance significantly correlated withhigher index levels, confirming that the index effectively captures the food …

Long Panel Studies Of Small-Scale Rural Societies In The Global South: What Is Their Value, Why Are They Rare, And Suggestions To Make Them Happen, Jonathan Bauchet, Ricardo Godoy, William R. Leonard, Victoria Reyes-Garcia, Asher Y. Rosinger, Susan Tanner, Eduardo A. Undurraga

Department of Agricultural Economics Faculty Publications

Many topics in the behavioral sciences and epidemiology require researchers to directly observe entities (e.g., individuals, households) over a long time to identify lasting effects. Long-term panel data collection is more common in high-income countries than in small-scale rural societies (SSRS) of low-income countries. SSRS are mobile, nature-dependent, linguistic minorities, and highly autarkic. Analyzing such data using a life-course perspective can help uncover patterns that align or upend what we know from high-income countries. This study a) reviews long (>∼10 year) panels in SSRS (n = 9), b) extends the analysis to cover somewhat comparable societies of smallholders (n …

Mitochondria-Er Contact Sites (Mercs) In The Cell Cycle: Molecular Architecture And Functional Remodeling Across Cellular States, Eduardo Silva-Pavez, Bruno Torres-Gonzalez, Michelle Sotomayor, Benjamín Cartes-Saavedra, Dorian V. Ziegler, Yessia Hidalgo-Fadic, Ulises Ahumada-Castro

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mitochondria–endoplasmic reticulum (ER) contact sites (MERCS) are nanoscopic, dynamic platforms integrating metabolism, signaling, and stress responses to regulate cell fate. These nanoscopic interfaces remodel continuously to meet the demands of proliferating, quiescent, and senescent cells. We synthesize evidence that MERCS actively coordinate local Ca2+ signaling, non-vesicular lipid transfer, and proteostasis to shape mitochondrial function and cellular homeostasis. We discuss how MERCS architecture changes across the cell cycle and during arrest, distinguishing adaptive from maladaptive remodeling, and consider therapeutic potential in aging and age-related disease.

“Our Culture Is Larger / Than The Life Of The Chick Pea”: A Thematic Analysis Of Food And Foodways In Palestinian Poetry From The Twentieth To The Twenty-First Century, Basmah Arshad

Dublin Gastronomy Symposium

Since the early twentieth century, Palestinians have used poetry as a means of remembering and celebrating their homeland amid its occupation and colonization. Naomi Shihab Nye, Rashid Husayn, and Zeina Azzam are understudied poets of Palestinian heritage. All three experiment with varying depictions of Palestinian food and foodways, and placing their poetry into conversation enables a greater understanding of how and why food is an enduring metaphorical vehicle for mourning, soothing, or surviving the Palestinian poet’s physical and emotional alienation from Palestine. There is a generational distinction in how poets identify said alienation. Husayn, who comes from an older generation …

A Sisyphean Carrot In Waiting For Godot, Thierry Dubost

Dublin Gastronomy Symposium

In Waiting for Godot, Beckett employs a variety of strategies to expose what it means to be human. Among them, one notes a recurring emphasis on eating scenes that reflect a lurking existential crisis illustrated by the characters’ failure to follow expected standards of commensality. In this respect, if one refers to Brillat-Savarin’s maxim “Tell me what kind of food you eat and I will tell you what kind of man you are,” one could start from physiological features that are given pride of place in the play to ponder over the importance of unexpected forms of nourishment as revealing …

“It’S The End Of The World As We Know It” And I Feel Hungry: Food In Dystopian And Utopian Fictional Futures, Deirdre Murphy, Maureen Costura

Dublin Gastronomy Symposium

In dystopian fantasy fiction and the more recent subgenre of hopepunk, representations of food—growing and scavenging it, preparing and eating it—reveal distinct but evolving perspectives on the collapse of human societies facing environmental, political, and economic disasters. As we examine these bodies of literature, contrasts abound. There is never enough food in dystopian fantasy. What is available is bland, repetitive, and dubiously nutritious. Trauma around food is ongoing. Scavenging highlights the anxiety of diminishing resources, while consumption is either solitary and lonely, or shared among small and struggling groups where meals only contribute to abiding grief. In all, food insecurity …

Changing Right Before Our Eyes: Landscape Transformation In New Mexico, Laura Mccarthy

Natural Resources Journal

No abstract provided.

The Role Of Anticipatory, Preparatory, And Transformative Governance In Wildfire And Watershed Resilience Strategies, Robin Kundis Craig, Melinda Morgan

Natural Resources Journal

Wildfire is a game-changer for both communities and ecosystems throughout the West, including in New Mexico. Building resilience to increasing numbers of wildfire events, especially when wildfires can shift communities, ecosystems, and combined social ecological systems (“SESs”) past tipping points and into new regimes requires new approaches to governance. Focusing on the Hermit’s Peak/Calf Canyon fire and New Mexico residents’ ongoing response, this Article examines post-fire needs before surveying new modes of governance that can help to address those needs in a climate change era. It ends with a summary of our engagement with the participants in the “Life After …

Forever Is Too Long: Rethinking Consent And Genetic Privacy Under The Fourth Amendment, Abigail Oberbeck

University of Cincinnati Law Review

No abstract provided.

Enemies To Lovers: An Unsuspecting Friendship In The Journey To Save The Endangerment Finding, Sophie Ballah

University of Cincinnati Law Review

No abstract provided.

Violent White Exclusionary Destruction Of Black Property Is A Public Nuisance: The Tulsa Race Massacre And Beyond, Eric Miller

University of Cincinnati Law Review

No abstract provided.

The Rubble Of Words: Food As A Device For Silence In A Time Of Polycrisis, Jennie Moran

Dublin Gastronomy Symposium

On the night of 03 August 2024, Adam Kelwick, the imam from the Abdullah Quillian Society Mosque in Liverpool crossed police lines and presented anti-immigration protesters with burgers and chips prepared in the mosque kitchen. This took place in the aftermath of the Southport stabbings and the worst outbreak of civil disorder in Britain for more than a decade. “We decided to deal with those people who came to protest against us in a way which we hoped could open up hearts and minds. We wanted to cook food for them.” This paper will examine the power of food to …

Oxo Made With Milk: The Trials Of The Colonial Housewife, Igor Cusack

Dublin Gastronomy Symposium

Colonisation may be seen as an essentially male process, imposing Western notions of household organization and gender on native women and on the colonial housewife. This is all part of the ideology of domesticity which permeated British colonial societies from the late nineteenth century until the independence of African states in the mid twentieth century. In this paper I will examine how food was used to combat various medical crises in British colonial Africa. The paper considers cookery books from South Africa, Rhodesia, Bechuanaland, Kenya, Nyasaland, Ghana and West Africa, focussing on sections entitled “for the invalid,” “invalid dishes” or …

Hospitality In Crisis: Deciphering Food Insecurity Among Migrants From A Derridean Perspective, Alexandra Constantinescu, Naz Ali

Dublin Gastronomy Symposium

Food insecurity faced by disadvantaged groups of migrants (i.e., voluntary migrants living in low-income households and forced migrants – namely asylum seekers) undermines the nature of hospitality, creating conditions of inhospitableness associated with hunger, injustice, insecurity, and poverty. This study presents a critical interpretation of hospitality in crisis by concentrating on food insecurity resulting from government and non-government food policies in England, that are inhospitable towards forced migrants – contributing to an area of enquiry with limited research in food and hospitality studies. The study draws on the teachings of Jacques Derrida, particularly his philosophical perspective on (in)hospitality/hostipitality, with conceptualisations …

Planting Oak Seedlings For Forest Regeneration, Ryan Bohannon

Forestry and Natural Resources

Oaks are an important component of forests across the Southeast and are favored for a variety of objectives, including the provision of wildlife habitat and timber. Planting oak seedlings can be an effective practice for promoting successful oak regeneration in managed forests. This publication provides forest landowners and managers with practical recommendations for oak enrichment planting, including species and seedling selection, seedling care, planting techniques, and post-planting practices to promote survival and growth.

Host Range And Characterization Of Phytophthora Species That Cause Plant Diseases In California, Dinh Hieu Pham

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Phytophthora is one of the most destructive genera of plant pathogens in California, posing significant threats to both nursery production and natural ecosystems. Phytophthora ramorum, the causal agent of Sudden Oak Death (SOD), has expanded its host range to include more than 100 plant species. In addition, Phytophthora elongata, previously isolated in Western Australia from Eucalyptus marginata in 2013, has recently been detected for the first time in the United States on Rhododendron species. This naturally raises concern that a new etiological species has entered the country. Therefore, the goal of this thesis study was three-fold:  i) to …

Early Life Exposure To Antibiotics Increases The Risk Of Myopia: A Retrospective Cohort Study, Peng-Tai Tien, Chang-Ching Wei, Sheng-Chun Lin, Ping Ping Meng, Yu-Te Huang, Jamie Jiin-Yi Chen, Ming-Yen Wu, Ying-Hsiu Shih, Tzu-Ju Hsu, Fuu-Jen Tsai, Yao-Chien Wang, Hui-Ju Lin, Lei Wan

BioMedicine

Background

Myopia is a growing health issue, expected to affect nearly half of the global population by 2050. Genetic predisposition and early environmental influences both play crucial roles in the development of myopia. Identifying modifiable risks and early interventions is critical. Antibiotics, commonly given to young children, may disrupt gut microbiota, which has been linked to ocular diseases in humans and animals.

Aim We aimed to investigate the association between antibiotic use in early life and the risk of developing myopia.

Methods Retrospective cohort study using data from a national health insurance database examined children aged three years or younger, …

Unveiling Immune-Related Gene Signatures In Triple Negative Breast Cancer Through Integrated Transcriptomic Analysis, Priyanga Paranthaman, Ramanathan Karuppasamy, Shanthi Veerappapillai

BioMedicine

Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options and poor prognosis. Understanding the underlying molecular mechanisms, particularly immune-related gene networks, is critical for identifying novel therapeutic targets. Aim: This study aimed to identify immune-related hub genes involved in TNBC progression by integrating microarray and RNA sequencing data. Methods: We integrated microarray and RNA sequencing datasets from five Gene Expression Omnibus (GEO) studies (GSE36295, GSE37751, GSE61724, GSE38959, and GSE58135) to identify differentially expressed genes (DEGs). Protein–protein interaction (PPI) networks were constructed using the STRING database. Key modules and hub genes were identified through network analysis. …

Evaluation Of Bai-Zhu (Atractylodes Macrocephala)-Based Herbal Formulae In Breast Cancer: Implications For Metastasis Via Zeb1 And Slug Modulation, Yen Shen Lu, Pei Yen Yeh, Ling-Chun Yeh, Chia-Lin Lee, Ying-Chyi Song

BioMedicine

Background: Bai-Zhu (Atractylodes macrocephala Koidz. [Asteraceae]) is classified in traditional Chinese medicine (TCM) as an herb that targets the gastric and pancreatic meridians to support normal nutrient uptake. As such, Bai-Zhu is commonly included in herbal formulations for treating gastrointestinal dysfunction and alleviating pain and swelling. Formulae containing Bai-Zhu are also frequently used as complementary or alternative therapies to mitigate the side effects of tumor treatments. However, their direct effects on cancer cells remain inadequately understood in modern biomedical science. This study aims to characterize the impact of Bai-Zhu-containing formulae on breast cancer cells using contemporary molecular and cellular …