Digital Commons Network^™

Exploring The Biological Basis For Exercise Neuroprotection In Parkinson’S Disease: A Cross-Sectional Study Of Exercise And Physical Activity On Inflammatory Cytokines And Neurotrophins, Leah Isabelle P. Alegre, Jacob M. Brewer, Adeline Florschutz, Kate E. Hamiltonthompson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Regular exercise and physical therapy are known to increase production of neurotrophins, including brain-derived neurotrophic factor (BDNF), and anti-inflammatory cytokines. These changes combine to theoretically protect and slow the progressive loss of neurons in Parkinson’s disease (PD). The purpose of this study was to examine the effect of exercise and physical activity on various anti-inflammatory and pro-inflammatory cytokines and neurotrophins in people with PD (PwP). This was a cross-sectional design involving PwP (n=37), aged 43-85 years, who participated in two 30-minute bouts of exercise (with brief rest breaks during and pre/post blood draws) separated by a week. Measures collected prior …

Effect Of An Exercise Protocol On Balance In Adults With Down Syndrome, Juan Bernal, Natalie Sato

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis: Down syndrome (Ds) is a complex genetic condition that can impact multiple systems of the body, including functional balance. Ds-specific impairments such as muscle hypotonia, ligamentous laxity, and decreased muscle strength, coupled with a sedentary lifestyle can result in poor motor control, altered proprioceptive function, static and dynamic instability. Visual and vestibular impairments are also common in this population, increasing fall risk and fear of falling, and discouraging participation in physical activity. The aim of this study is to analyze the impact of a physical therapy-based exercise program on the functional balance of adults with Ds.

Number of Subjects: …

Junctional Actin As A Mechanical Hub For Supracellular Actomyosin Force Transmission During Apical Constriction, Jasneet Brar

UNLV Theses, Dissertations, Professional Papers, and Capstones

Apical constriction is a conserved morphogenetic mechanism that drives epithelial folding during development. During ventral furrow formation in Drosophila melanogaster, contractile actomyosin networks generate forces that reduce apical cell area resulting in tissue invagination. For these cell-scale forces to produce coordinated tissue-scale changes, contractile networks must be mechanically integrated across neighboring cells. Although adherens junctions are known to mediate this coupling, it is unclear how junctions are integrated into cortical actin cytoskeleton, which directly determines cell, and consequently tissue, shape. This thesis tests the hypothesis that supracellular actomyosin organization during apical constriction depends on distinct adherens junction based mechanical couplings: …

Interpretable Deep Learning Models For Trustworthy Prediction Of Enzyme Functions, Louis Dumontet

UNLV Theses, Dissertations, Professional Papers, and Capstones

Trustworthy prediction of enzyme function from protein sequences remains a central challenge in computational biology, particularly when annotated data are limited, imbalanced, or incomplete. This dissertation develops interpretable deep learning methods for enzyme discovery and enzyme function prediction from amino acid sequences. First, it introduces PEPIC, an interpretable convolutional neural network for substrate-level prediction of hydrolytic plastic-degrading enzymes. Using curated and expanded sequence datasets, PEPIC improved predictive performance over benchmark methods, identified sequence regions aligned with catalytic and substrate-binding residues, and supported the discovery and experimental validation of a previously uncharacterized PET-degrading enzyme. Second, this dissertation investigates the integration of …

Correlation Of Buccolingual Angulation Of Posterior Teeth And Transverse Skeletal Width In Adult Orthodontic Patients: A Retrospective Cbct Study, Anya T. Hatfield

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective:

Accurate evaluation of transverse skeletal relationships is essential for orthodontic diagnosis and treatment planning. Dentition may compensate for skeletal discrepancies through buccolingual tipping of posterior teeth, potentially masking underlying transverse imbalance. The purpose of this study was to investigate the relationship between transverse skeletal width and posterior tooth angulation using cone-beam computed tomography (CBCT).

Methods:

Sixty-six pre-orthodontic adult CBCT scans were analyzed. Maxillary and mandibular transverse skeletal widths were measured at the level of the first molar furcation using buccal cortical plate– to–buccal cortical plate landmarks. Buccolingual angulation of the first and second premolars and first and second molars …

Feasibility Of High-Intensity Training (Hit) For Academic Engagement In Young Adult Women, Raleah Tenorio Kastner

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose: This feasibility study aimed to identify the impact of a high-intensity training (HIT) exercise protocol on healthy behaviors related to academics to decrease stress levels and enhance academic engagement and overall quality of life in young adult female students, measured by a modified version of the National Survey of Student Engagement (NSSE) and the Occupational Experience Profile (OEP).

Methodology: One young adult female student enrolled at UNLV who is 18-25 years old was recruited via convenience sampling to engage in a 12-session HIT exercise program, developed by a certified personal trainer and licensed occupational therapist, with the participant’s target …

A Tale Of Two Mammals: Tenrec Ecaudatus And Homo Sapiens, Debra Renee Kerr

UNLV Theses, Dissertations, Professional Papers, and Capstones

Most modern mammals maintain stable body temperatures (Tb) ~37ºC and high metabolic rates. Hibernators, like ground squirrels, are homeothermic during the active summer season, but are heterothermic during the hibernation season. During the hibernation season, ground squirrels follow a predictable pattern of torpor bouts interrupted by interbout arousals. Tenrecs are unusual because they are heterothermic and heterometabolic even during the active season. Previously, ground squirrel bile constituents were shown to be predictive of whether a squirrel is in the summer active or winter hibernation season. We found tenrec bile constituents were highly variable and not predictive of seasonal and metabolic …

P300/Cbp Inhibition With Inobrodib In Combination With Gilteritinib And Venetoclax Targets Leukemia Stem Cells In Epigenetic Mutant Aml, Melanie L. Goetz, Jennifer S. Romer-Seibert, Amanda M. Versace, Scott Kogan, Chetan Jeurkar, Robert L. Bowman, Nigel Brooks, Kris Frese, Sara E. Meyer

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Acute myeloid leukemia (AML) is a fatal blood cancer with cytotoxic chemotherapy offering at best 25% 5-year survival. While targeted BCL2 and FLT3 inhibitors venetoclax and gilteritinib are used upfront in the treatment of a subset of adult patients with AML and help to extend the survival of some patients, a curative treatment combination with minimal side effects has yet to be discovered. We find that use of the dual histone acetyltransferase p300/CBP bromodomain inhibitor CCS1477 (inobrodib), together with venetoclax and gilteritinib, virtually eliminates leukemia stem cells in an aggressive preclinical model of DNMT3A/FLT3-mutant AML by impairing pro-oncogenic survival and …

Impairment And Disability In Mesoamerica: Bioarchaeological Evaluation And Interpretation Of The Maya Of Palenque, Dayanira Lopez

UNLV Theses, Dissertations, Professional Papers, and Capstones

The application of disability theory to the past is of growing interest among bioarchaeologists, both nationally and internationally. However, its application poses greater challenges when considering ancient contexts, such as Mesoamerica. Nonetheless, engagement with disability studies has led to the development of various theoretical frameworks in bioarchaeology, including dis/ability. This model views physical impairment as a fluid state that may exhibit adaptability and resilience rather than a biological deficit. Importantly, it views ability on a spectrum and does not make assumptions about social and cultural perceptions of ability where there is a lack of contextual data. Thus, it is a …

Exploring The Impacts Of Contextualized Learning In An Engineering-Specific Corequisite Precalculus Course On Student Achievement, Motivation, And Belongingness, Amy Mathis-Leonard

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study examines the design and implementation of a contextualized engineering-specific corequisite Precalculus I course and its impacts on student achievement, motivation, and sense of belonging. This study was conducted in response to decreasing national rates of mathematical readiness, the elimination of stand-alone developmental mathematics courses across multiple states and systems, and the demand for research related to effective corequisite models in mathematics coursework. The intervention created an experimental section of corequisite Precalculus I in which all the students were engineering majors who did not demonstrate readiness for a college-level precalculus course. Unit lessons incorporated engineering-specific topics and career-oriented discussions. …

A Comparison Of Changes In Vertical Cephalometric Measurements In Patients Treated With Invisalign And Traditional Fixed Orthodontic Appliances: A Retrospective Study, Shayna Mesko

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Since their introduction into the field, clear aligners have significantly grown in popularity in orthodontics as they offer enhanced esthetics, improved oral hygiene, and patient comfort. Clear aligners have allowed clinicians to simulate treatment outcomes, streamline treatment with reduced office visits, control force and movement per tray, and provide more precise control of focal tooth movements. This can enhance efficiency in achieving specific and very finite orthodontic goals. Since their inception, clear aligners have evolved from only accomplishing simple tooth movements to achieving more complex and comprehensive mechanics. While they have significantly advanced, there are still limitations in efficacy …

Phase Identification Of (La, Sr)Coo3 Solid Oxide Cell Electrode Films Using Dft Based Exafs, Musab A. Siddiqui

Seton Hall University Dissertations and Theses (ETDs)

Perovskite structured mixed ionic electronic conductor (MIEC) materials formed as films by metal-organic precursor deposition have excellent electrochemical performance in solid oxide cell (SOC) air electrode applications due to the large surface area provided by the manufacturing approach. MIEC films created by metal organic precursor deposition are often multi-phased due to low heat treatment temperatures and locally generated low oxygen partial pressures caused by the release of carbonaceous gases during the drying step of the fabrication process. In this work, we use extended x-ray absorption fine structure spectroscopy (EXAFS) to examine the phase contents of La0.8Sr0.2CoO3 (LSC82) and La0.6Sr0.4CoO3 (LSC64) …

Cold Plasma Treatment Of Hydroponically Grown Basil: Effects On Essential Oil Composition For Sustainable Applications (Ocimum Basilicum), Judith Serwaa Marfo

Seton Hall University Dissertations and Theses (ETDs)

Abstract Essential oils are known to have medicinal benefits and pharmaceutical applications. This study investigates the impact of cold plasma treatment on hydroponically cultivated basil (Ocimum basilicum), focusing on physical growth traits, and essential oil composition. Preliminary trials validated our solvent extraction protocol using IPA, hexanes, and methanol without heat on store-bought basil. Rotary evaporation and GC-FID analysis successfully identified key compounds; eugenol, estragole, eucalyptol, and linalool. Plasma-treated hydroponic plants exhibited enhanced physical characteristics, including larger leaves and intensified green pigmentation, compared to untreated controls under identical conditions. The plasma treatment didn't just increase how much oil was extracted, but …

Leading Beyond Concrete Ceilings: The Lived Experiences Of African American Women Presidents At Predominantly White Institutions, Marsha Philemon

Seton Hall University Dissertations and Theses (ETDs)

Despite their significant educational attainment, African American women remain significantly underrepresented in higher education presidential leadership, comprising fewer than 5% of presidents at Predominantly White Institutions (PWIs). The purpose of this phenomenological study was to examine the lived experiences of 13 African American women who serve or have served as presidents of four-year, doctoral-granting PWIs. It explored how they ascended to the presidency, navigated barriers, and sustained themselves in the role. Guided by the engagement, retention, and advancement (ERA) model and by glass ceiling theory, semi-structured interviews were conducted to better understand each participant’s presidential journey. In response to the …

Queerscape: Transcending Urban Division, Alex Blake

Hospitality Design Graduate Student Capstones

The project seeks to demonstrate how infrastructure can act as a symbolic anchor, offering a framework for queer urban design that simultaneously addresses safety and cultural visibility. While site-specific, the methodology is intended to inform future interventions in districts for queer and other marginalized communities.

Mindfulness-Based Interventions: Improving Quality Of Care In Breast Cancer, Deborah Schindele

Group: Northern Arizona University School of Nursing, DNP Doctoral Papers

Breast cancer is the second leading cause of death in women and leads to decreased quality of life owing to increased anxiety, depression, fatigue, stress, and a lack of social support. The American Society for Integrative Oncology ranks mindfulness-based interventions (MBI) as the most highly recommended integrative interventions known to decrease anxiety, depression, and fatigue, and improve the quality of life of breast cancer patients. However, they were not regularly used or recommended by support group facilitators of the project. A quality improvement project was implemented with the five support group facilitators to address this deficit. The purpose was to …

Tumor Implantation Site Of Syngeneic Oral Cancer Models Differentially Induces Site-Dependent Local And Systemic Immunosuppression, Andrea H Molina, Gemalene M Sunga, Shawn Nguyen, Neeraja Dharmaraj, Ratna Veeramachaneni, Roberto Rangel, Jeffrey N Myers, Jeffrey D Hartgerink, Andrew G Sikora, Simon Young

Faculty, Staff and Student Publications

Background/objectives: Preclinical studies of head and neck squamous cell carcinoma (HNSCC) commonly use subcutaneous heterotopic (flank) tumor models for simplicity; however, orthotopic models may better reflect the native tumor environment. Direct comparisons of the tumor immune microenvironments (TIME) and tumor-draining lymph nodes (tdLNs) between these models remain limited. Better understanding of site-specific immune differences could improve model selection and interpretation of translational HNSCC studies.

Methods: ROC1 tumors were established in murine heterotopic and orthotopic sites, followed by assessment of tumor growth kinetics, survival, and the tumor microenvironment. Immune composition of tumors, blood, tdLNs, and spleen was evaluated at three tumor …

Protecting Galápagos’ Marine Ecosystems: Biosecurity And Network Design Against Invasive Species From Tourist Vessels, Marnie L. Campbell, T.U. Le, Chad Hewitt

Research outputs 2022 to 2026

The modern world is characterized by high connectivity, enhancing economic productivity, and global communication, but outpacing our ability to manage its consequences. This connectivity increases the risk of pathogen, pest, and invasive species transmission. In the Galápagos islands, Ecuador, tourist vessel networks operate with limited restrictions and connect high conservation value locations, boosting tourism and the economy. These vessels frequently travel between multiple islands, leading to moderate connectivity and high vessel promiscuity. To prevent the spread of invasive species via these vessels, we propose a biosecurity system that combines social network tools with risk management frameworks that balances environmental protection …

Postural And Load Dependent Modulation Of Lower Limb H-Reflex Excitability After Stroke, Daniel Bamiro, Matthew Berdiago, Ethan Hunter, Tia Nguyen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis

Leg stiffness is regulated by reflexive, intrinsic, and passive mechanisms, which are influenced by posture, body weight loading, and motor task demands. After a stroke, the capacity to modulate these mechanisms is often compromised. The H-reflex is a widely used electrophysiological tool to assess the excitability of the Ia afferent pathway within spinal circuitry. Although prior studies in healthy individuals have examined limb loading effects, results have been variable, and the role of postural and loading changes during standing remains underexplored, particularly in individuals post-stroke. This study investigated how different postural and limb loading conditions, specifically prone, standing, and …

Unknowing Sacrifices: Public Health And Radiation Illness In New Mexico And Nevada, 1940s-1960s, Beatriz Avila-Marquez

UNLV Theses, Dissertations, Professional Papers, and Capstones

The detonation of the first atomic bomb in the early morning of July 16, 1945, in New Mexico welcomed the atomic age that forever changed the world. After that day, thousands of lives were lost due to nuclear weapons, and hundreds of thousands more continued to suffer from the effects of atomic testing. The Atomic Energy Commission, fueled by the arms race of the Cold War, chose Nevada to continue the United States’ nuclear weapons testing. Knowledge of the dangers of radiation exposure, the effects of radiation, and techniques to prevent exposure are now available in part due to the …

Resilience Of Orthodontic Sealants Against Degradation And Microbial Adhesion: A Comparative Study, Michelle X. Cui

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background:

White spot lesions are one of the most common complications encountered during orthodontic treatment. These lesions begin as demineralization of enamel around the appliance due to plaque buildup, resulting in compromised aesthetics. As they continue to develop, white spot lesions progress to cavitation, potentially threatening pulpal vitality, resulting in an increased financial burden for patients. Preventative strategies include patient education, consistent oral hygiene protocols, and the use of fluoride-releasing agents. Orthodontic sealants such as Opal® Seal™ (Ultradent) (OS) and L.E.D. Pro Seal® (Reliance) (PS) have been developed to release and recharge fluoride, thereby reducing the incidence of white spot …

Establishing A Comprehensive Framework For Sfrt Lattice Treatments: Optimization, Planning, And Clinical Evaluation, Gregory M. Gill

UNLV Theses, Dissertations, Professional Papers, and Capstones

Spatially fractionated radiation therapy (SFRT) using lattice radiotherapy (LRT) has emerged as a promising treatment technique for bulky, nonresectable tumors by delivering spatially heterogeneous dose distributions consisting of high-dose vertices embedded within lower-dose regions. Although early clinical experiences have demonstrated potential therapeutic benefit, widespread clinical implementation of LRT remains limited due to the absence of standardized treatment planning workflows, consistent optimization strategies, and clearly defined evaluation metrics for heterogeneous dose distributions. The objective of this study is to develop and evaluate a structured framework to support efficient, reproducible, and safe clinical implementation of LRT.

To address these challenges, a comprehensive …

At The Crossroads Of Traditional And Nuclear Forensics: Decontaminating Radiologically Contaminated Dna Evidence Using Magnetic Beads, Rin Nyx Ruby

UNLV Theses, Dissertations, Professional Papers, and Capstones

Known for its impressive discriminatory power, deoxyribonucleic acid (DNA) fingerprinting stands as the “gold standard” of forensic investigation. However, complications arise when such evidence is contaminated with radioactive material. Though biological samples exposed to ionizing radiation can still yield comprehensive DNA profiles, most forensic laboratories lack the facilities which meet the safety and security requirements necessary for handling radioactive material. While nuclear facilities can decontaminate samples prior to forensic analysis, conventional methods for radiological decontamination – such as mechanical cleaning and chemical washes – may degrade the quality of the forensic evidence. The purpose of this study is to evaluate …

Is Forgetting Independent Of Learning? An Examination Of Initial Learning Across Alternative Forgetting Analyses, Rhiannon Nicole Soriano Smith

UNLV Theses, Dissertations, Professional Papers, and Capstones

A long-standing debate has reappeared regarding whether the rate of forgetting is independent or dependent upon the initial degree of learning. Interestingly, both conclusions have been supported. These diverging conclusions could be due to the analytical method and operational definition of forgetting employed: Researchers supporting independence typically measure forgetting as the number of items forgotten at a given retention interval, while those in favor of dependence typically measure forgetting as the number of items forgotten between test intervals. The current study tested whether the degree of learning affects the rate of forgetting for recognition accuracy (da) and other memory processes …

Anatomy Academy: An Interdisciplinary Approach To Enhancing Youth Health Literacy, Roselle Antikoll, Jonathan Nakamine, Jessica Tran

UNLV Theses, Dissertations, Professional Papers, and Capstones

To enhance health literacy among the underserved youth population in Las Vegas, Nevada, Anatomy Academy (AA) is an eight-week, seven-lesson program that educates students through structured and interactive lesson plans covering basic anatomy, physiology, and nutrition. Our program was implemented in three different Title-I elementary schools between five different classrooms across Las Vegas. These lesson plans highlighted specific body systems including the cardiovascular, musculoskeletal, and gastrointestinal systems. Our primary aim was centered around involvement of more interdisciplinary healthcare professions including occupational therapy, dental medicine, osteopathic medicine, and nutrition to aid in the delivery of the AA program. Our secondary aim …

Effectiveness Of Cognitive Stimulation Therapy On The Quality Of Life Of Adults With Dementia: A Secondary Analysis, Evelyn Airam

UNLV Theses, Dissertations, Professional Papers, and Capstones

This secondary analysis study evaluated the effectiveness of Cognitive Stimulation Therapy (CST) on quality of life (QoL), depressive symptoms, and cognitive function in 108 community-dwelling older adults with cognitive impairments, including dementia. Outcomes involved Quality of Life (QoL) measured by the Quality of Life in Alzheimer’s Disease (QoL-AD), symptoms of depression by the Cornell Scale for Depression in Dementia (CSDD), and cognitive function using the Saint Louis University Mental Status (SLUMS). After the CST, significant improvements were observed in QoL (p = .004), depressive symptoms (p = .002), and cognitive function (p < .001), with small effect sizes. Additionally, a significant interaction between sex and dementia diagnosis status was found in predicting cognitive changes, suggesting that the relationship between dementia diagnosis and cognitive improvement differs by sex. No between-group differences were found for QoL or depression. Findings support CST as a multidimensional, non-pharmacological intervention that improves cognitive, psychological, and social outcomes. Although effects were small, consistent improvements are clinically meaningful given the progressive nature of dementia. This study extends existing literature by demonstrating CST’s effectiveness in a community-based setting and reinforces its alignment with occupational therapy’s emphasis on participation and holistic care. Results highlight the need for early intervention and expanded access to CST programs to enhance quality of life in this population.

Fostering Adolescents’ Social-Emotional Skills In A Community Setting, Elizabeth Benitez

UNLV Theses, Dissertations, Professional Papers, and Capstones

Adolescents face growing emotional, behavioral, and social challenges, especially in community recreation settings with high energy, peer interaction, and sensory demands. These environments often expose difficulties in emotional regulation, communication, and conflict management, highlighting the need for structured social-emotional learning (SEL). This capstone project aimed to develop and implement an occupation-centered SEL program integrating the Zones of Regulation (ZOR), CASEL competencies, and Developmental, Individual Differences, Relationship-Based (DIR) Floortime principles within the Clark County Hollywood Parks and Recreation after-school program. Guided by the Person–Environment–Occupation (PEO) model, the project sought to help adolescents practice emotional awareness, self-management, and interpersonal skills in their …

Digital Literacy And Language Proficiency As Factors Of Accessible Digital Training In The Hospitality Industry: Employee Perspectives Of Training And Working In A Diverse Industry, Gillian Bowden

UNLV Theses, Dissertations, Professional Papers, and Capstones

This explanatory sequential mixed methods study explored how digital literacy and language proficiency impact employees’ access to and engagement with digital training, as well as how these experiences influence their perceptions of training and the organization. In the quantitative phase, survey data were collected from hourly employees at a large foodservice corporation (n=67). Four constructs were assessed: digital literacy, language proficiency, accessibility, and engagement. Results indicated strong, statistically significant relationships with higher levels of digital literacy and language proficiency associated with greater accessibility and increased engagement with digital training materials. The large effect sizes suggest these competencies play a meaningful …

Got Sleep?: The Introduction Of Sleep Hygiene To Justice Involved Individuals, Charisma Lynn Cato

UNLV Theses, Dissertations, Professional Papers, and Capstones

Individuals transitioning out of incarceration often experience challenges with sleep due to the residual effects of confinement. Although this is common among justice-involved individuals, there is limited research on how to address their sleep hygiene self-efficacy after release. Furthermore, despite the wide use of social-emotional learning (SEL) across multiple disciplines, little is known about its influence on sleep-related behavior change in re-entry populations. To address this, the Got Sleep program, designed and implemented at Hope for Prisoners (HOPE), a community site geared toward re-entry assistance, integrated occupational therapy (OT) principles and an SEL approach with practical sleep hygiene strategies to …

Inclusiveness With Sensory Maps; Enhancing Engagement In A Children's Museum, Victoria E. Davila

UNLV Theses, Dissertations, Professional Papers, and Capstones

Sensory processing challenges can affect a child’s ability to engage in play, especially when participating in community activities. When a child feels overwhelmed by sensory features in an environment, such as noise or bright lights in a community space, they may experience sensory overload. Caregivers often observe this behavior but may not have access to resources to help their child navigate these challenges. This capstone project aimed to implement a program development initiative at the Discovery Children’s Museum focused on developing sensory-inclusive resources for caregivers visiting the museum with a child. The role of occupational therapy in this project is …