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Adjunctive Probiotic Use During Antibiotic Exposure In Very Preterm Infants: A Narrative And Translational Review, Mustafa Törehan Aslan, Mustafa Altındiş, Fahri Ovalı

Journal of Pediatric Infectious Diseases

Infants born before 32 weeks of gestation are highly susceptible to late-onset sepsis because of immune immaturity, impaired intestinal barrier function, and frequent broad-spectrum antibiotic exposure. Whether probiotics should be continued or initiated during antibiotic therapy remains unresolved and is often conflated with routine prophylaxis in stable infants. This SANRA-guided structured narrative and translational review synthesized clinical, microbiome, resistome, mechanistic, and safety evidence identified in PubMed/MEDLINE, Scopus, and Web of Science through July 1, 2026, across three contexts: stable antibiotic overlap, suspected sepsis, and confirmed or unstable sepsis. Pooled prophylactic analyses suggest a small, heterogeneous reduction in late-onset infection (risk …

Analysis Of Risk Factors And A Predictive Model For Recurrent Febrile Seizures Within A Single Febrile Illness In Children, Zheng Ge, Pao Yu, Kun Chen, Bi Zhou

Journal of Pediatric Infectious Diseases

Objective: To investigate predictive factors for seizure recurrence in children with febrile seizures (FS) within a single febrile illness, providing a basis for early clinical identification and preventive measures. Methods: We conducted a retrospective analysis of children with FS admitted to the Department of Pediatrics, Suzhou Hospital Affiliated to Anhui Medical University, from April 2023 to December 2025. A total of 337 children met the inclusion criteria. Children with more than one seizure within the same febrile ilness were classified as the recurrent febrile seizures (RFS) group, and those with a single seizure as the non-recurrent febrile seizures (NRFS) group. …

Age-Dependent Variations In Clinical Presentation, Laboratory Parameters, And Coronary Outcomes In Kawasaki Disease: A 10-Year Retrospective Cohort Study Of 480 Pediatric Patients In Eastern China, Zhuying Zhou, Chen Wang, Aole Li, Saeed Saboor, Xiaoli Li, Xiaowei Li, Xianmei Huang, Chunming Jiang

Journal of Pediatric Infectious Diseases

Objective: This study investigated the age-dependent clinical characteristics of Kawasaki disease (KD) in pediatric patients and assessed the influence of age on disease presentation and outcomes. Methods: A retrospective analysis was conducted of 480 children diagnosed with KD who were admitted to Hangzhou First People's Hospital between 2013 and 2022. Subjects were stratified into two cohorts based on age: <2 years and 2-14 years). Demographic data, clinical manifestations, laboratory parameters, comorbidities, and coronary artery abnormalities were comprehensively evaluated across the age groups. Results: Time from symptom onset to diagnosis was significantly prolonged in the older cohort (z=-2.70, P=0.007). The incidence of cervical lymphadenopathy was markedly higher in older children (χ²=15.12, P<0.001), while peripheral extremity changes were significantly less frequent (χ²=5.79, P=0.016). The younger cohort exhibited significantly elevated platelet counts, alanine aminotransferase, and NT-proBNP levels compared to older patients (z=-3.57, P<0.001; z=-2.39, P=0.02; z=-3.59, P<0.001, respectively). Coronary artery dilatation and aneurysm formation occurred more frequently in younger patients (z=7.70, P=0.006; z=14.63, P<0.001). However, coronary artery recovery rates following intravenous immunoglobulin therapy showed no significant inter-group differences (P>0.05). Conclusions: The clinical presentation of KD demonstrates significant age-dependent variation. Clinicians should maintain a high index of suspicion for KD in older children presenting with fever and cervical lymphadenopathy. In younger patients with KD, close monitoring of hepatic function, platelet …

Identification Of Ca2 As A Potential Candidate Gene Involved In The Therapeutic Effect Of Huatan Huoxue Decoction On Polycystic Ovary Syndrome: An Integrated Study Of Network Pharmacology, Mendelian Randomization, And Experimental Validation, Chan Zhu, Yijin Zhang, Panwei Hu, Cong Qi, Qiu Chen, Hong Yang, Jing Li

Journal of Food and Drug Analysis

Purpose: Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Methods: Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for PCOS from the FinnGen R12 database. These targets were integrated with the active ingredients and protein targets of HTHXD retrieved from the TCMSP and BATMAN-TCM databases for network pharmacology analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted. Core targets were validated using molecular docking. Experimental validation was performed using a letrozole-induced …

Preparation And In Vitro Evaluation Of Gastro-Retentive Tablets Of Frusemide Using Gas Generating Excipients As Floating Mechanism, Yousif K. Younis, Ahmed Yousif Fadhel, Nihad Hussein Ahmed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Frusemide is a loop diuretic used for hypertension, heart failure among many other indications. It has an absorption window in the stomach and it's a class IV drug according to BCS with low bioavailability.
Floating tablets are one of the dosage forms that is best suited for drugs with such absorption window and gas generating excipients can be used to reduce floating lag times even more than traditional floating tablets that relay on density difference alone.
The aim of the study was to investigate the feasibility of floating tablets as a convenient dosage form for oral administration of frusemide aiming …

Impact Of Erythropoietin Therapy On Inflammatory Biomarkers In Chronic Kidney Disease: A Comparative Study, Riyam Naji Al_Alwani, Jahanbakhsh Asadi, Zainab Mohammadi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Chronic kidney disease (CKD) is a progressive disorder frequently complicated by anemia and a persistent inflammatory state, both of which significantly contribute to morbidity and mortality. Reduced renal production of erythropoietin (EPO) is the primary cause of anemia in CKD. Emerging evidence suggests that EPO may exert anti-inflammatory and metabolic effects beyond its hematopoietic role. This study aimed to compare serum EPO levels and inflammatory biomarkers in CKD patients treated with EPO versus untreated CKD controls.
Material and Methods: This cross-sectional analytical study was conducted on 60 adult patients with CKD undergoing regular hemodialysis. Participants were divided into two …

Current Advances In Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, And Future Perspectives, Mohamed E. Abd El-Hack, Mahmoud Moustafa, Mahmoud Kamal, Vincenzo Tufarelli, Muhammad Arif, Laith Aldabbagh

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Cancer immunotherapy has emerged as a transformative therapeutic strategy that harnesses the host immune system to recognize and eliminate malignant cells. This review provides a comprehensive overview of current immunotherapeutic approaches, including immune checkpoint inhibitors (ICIs), monoclonal antibodies (mAbs), cancer vaccines, dendritic cell (DC)-based vaccines, chimeric antigen receptor (CAR)-T cell therapy, and oncolytic virus therapy. The mechanisms of action, therapeutic applications, and clinical benefits of each modality are discussed. Monoclonal antibodies selectively target tumor-associated antigens, whereas ICIs restore antitumor immunity by blocking inhibitory immune checkpoints. Cancer vaccines and DC-based vaccines enhance antigen-specific immune responses, while CAR-T cell therapy employs genetically …

Computational Design, Molecular Docking, Sar, And Admet Analysis Of Novel Jak1 Inhibitors As A Possible Treatment For Rheumatoid Arthritis, Sarah Ahmed Waheed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Rheumatoid arthritis is an inflammatory autoimmune disease affecting the joints which eventually leads to systemic comorbidities. Its pathogenesis was attributed to disturbances in the Janus Kinase/Signal Transducer and Activator of Transcription signaling pathway. In this research, an innovative lead compound C6 was created and docked toward Janus Kinase1 (JAK1). The docking process was confirmed by re-docking of the co-crystallized ligand MI1 (Tofacitinib). C6 showed a predicted docking score of -9.17 kcal/mol, with enhancement of 1.26 kcal/mol over Tofacitinib. Evaluation of the interactions showed a framework of five hydrogen bonds within the binding site involving an important contact with Glu966 as …

Designing High-Resilience Hybrid Metamaterials: A Systems Engineering Specification For Elemental Hybridization, Solitonic Stabilization, And Non-Destructive Process Verification In Artificial Crystal Lattices, Christopher L. Eckes

Defensive Publications Series

Traditional artificial crystal lattices grown via high-mass commercial methods exhibit acute failure modes under extreme operational environments. These loops manifest as high-frequency acoustic micro-cracking along crystal grain boundaries during cyclic load profiles, or structural delamination driven by thermal expansion differentials across thin-film interfaces.

This specification introduces a formalized systems engineering framework for the elemental hybridization of lab-grown crystal substrates—specifically Thin-Film Lithium Niobate (LiNbO₃) and 3D Self-Assembled Inverse Opal Lattices. By strategically infiltrating these substrates with low-weight-fraction Graphene Oxide (GO) nanosheets and Boron Nitride Nano-Tubes (BNNTs), we create hybrid, non-linear metamaterials that isolate, dampen, and redirect destructive kinetic and thermal wave …

Electrospun Pvp/Zno/Ha Coatings On Silane-Modified Zk60: Corrosion, Antibacterial Activity, And In Vitro Apatite Formation, Qasim Saad Abdulwahid, Akeel Dhahir Subhi, Iman Adnan Annon

Engineering and Technology Journal

This study investigated a two-stage surface modification strategy for ZK60 magnesium alloy based on 3-aminopropyltriethoxysilane (APTES) pretreatment followed by electrospun polyvinylpyrrolidone (PVP) nanofibers containing ZnO and hydroxyapatite (HA) nanoparticles. Three PVP/ZnO/HA formulations were prepared to examine the effect of nanoparticle loading, and corresponding coatings with and without APTES pretreatment were compared. The coatings were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM/EDX), and a cross-hatch adhesion test. Corrosion behavior was evaluated in simulated body fluid (SBF) using open-circuit potential (OCP) monitoring and potentiodynamic polarization. Antibacterial activity was screened against S. …

Corrosion Inhibition By Carboxymethyl Cellulose Doped With Graphite Nanosheet And Silica Nanoparticles In Seawater Environment, Mohamed R. Mohssen, Sinan S. Hamdi, Rana A. Anaee, Mathew T. Mathew

Engineering and Technology Journal

This work aims to inhibit carbon steel surface as pipelines by adding carboxymethyl cellulose (CMC) with three concentrations (1, 3 and 5 g/L) in seawater environment at four temperatures in the range of 298 – 328 K. The investigation was done by recording Tafel plots and EIS curves to show that the lowest concentration is the best to protect the steel surface with efficiencies ranged between 95.68 – 89.36 % that decrease with increasing temperature due to the decomposition of CMC that begin after ≈ 308 K. An attempt to enhance the protection by CMC at higher temperature has been …

Hidden In Plain Sight: Uk Social Work Educator Views Of Preparedness To Work With Individuals And Families Affected By Abi., Caroline Bald, Alyson Norman, Akudo Amediegwu, Talis Spirit, Temi Ademakinwa, Mark A. Linden, Mark Holloway, Michael Clarke, Andrew Bateman

School of Psychology

Acquired brain injury (ABI) is the leading cause of adulthood injury-related death and disability worldwide. Despite ABI’s prevalence, little is known about the extent to which social workers are prepared for brain injury working and specifically pre-qualifying brain injury curricula. This study employed a nine-item survey regarding brain injury social work knowledge. The survey asked about curricula inclusion within social work pre-qualification via multiple education providers to understand the extent to which brain injury training is incorporated within UK courses. This included a series of open-ended questions. Data from 36 survey respondents identified that 1) there was an acknowledged gap …

Involvement Of Melatonin In The Regulation Of Reactive Oxygen Species Levels In Plants, Bariş Uzi̇lday, Oğuzhan Yilmaz, Tolga Yalçinkaya, Zehra Özgecan Tanyolaç, İsmai̇l Türkan, Rengi̇n Özgür Uzi̇lday

Turkish Journal of Botany

Abiotic stress conditions impair plant metabolism partly by inducing the excessive production of reactive oxygen species (ROS). Melatonin, a multifunctional indoleamine, has emerged as an important regulator of plant responses to oxidative stress. This review highlights recent findings on the interactions among phytomelatonin, ROS homeostasis, antioxidant metabolism, photosynthetic protection, stress priming, and abiotic stress tolerance. We discuss how melatonin modulates the antioxidative response under diverse stress conditions and evaluate its effects on photosynthetic performance, ROS signaling, and membrane stability. Special attention is given to priming studies showing that melatonin pretreatment can improve stress tolerance. Emerging evidence from plant tissue culture …

Complete Chloroplast Genome Analysis Of Critically Endangered Endemic Prangos Denticulata And Insights Into Its Evolutionary Dynamics, Ayşenur Bozkurt, Doğa Seli̇n Kayihan, Hali̇s Batuhan Ünal, Ceyhun Kayihan

Turkish Journal of Botany

Prangos denticulata (Apiaceae) is a critically endangered and narrowly endemic species restricted to Ankara, Türkiye. To provide genomic resources for its conservation and evolutionary study, we sequenced, assembled, and annotated its complete chloroplast genome using short-read next-generation sequencing. The circular plastome was 153,486 bp in length, exhibiting the typical quadripartite structure with a large single-copy (86,440 bp), small single-copy (17,894 bp), and two inverted repeats (49,152 bp), and an overall GC content of 37.8%. A total of 116 genes were identified, including 92 protein-coding, 31 tRNA, and 5 rRNA genes, of which 20 contained introns. Comparative analyses with P. trifida, …

Drought Priming Improves Waterlogging Tolerance In Alfalfa, But Less Effectively Than Waterlogging Priming, Gürkan Demi̇rkol, Ni̇lüfer Kara

Turkish Journal of Botany

Waterlogging severely restricts growth and productivity in alfalfa (Medicago sativa L.), necessitating effective strategies to improve stress tolerance. This study investigated whether drought priming or waterlogging priming could enhance tolerance to subsequent waterlogging stress in the alfalfa cultivar “Bilensoy-80”. Plants were subjected to drought priming, waterlogging priming, or no priming prior to progressive waterlogging stress for 0, 4, 8, 12, 16, and 20 days. Waterlogging priming consistently alleviated growth inhibition, maintained chlorophyll content, and reduced oxidative damage under prolonged stress. Drought priming was associated with partial cross-tolerance, particularly through improved root growth, plant water status, and oxidative stress responses, although …

Harmonicthreads: A Formative Evaluation Of A Fabric-Based Digital Musical Instrument Toward Inclusive Music-Making, Ellie Nguyen, Franceli L. Cibrian

Engineering Faculty Articles and Research

Background:

Inclusive music-making requires instruments that support varied bodies, abilities, musical backgrounds, and forms of participation. Digital musical instruments provide diverse approaches to sound creation, and fabric-based interfaces offer an alternative interaction modality that may support participation for some users and contexts. Their tactile and deformable properties enable forms of interaction that differ from conventional rigid or screen-based controllers and may offer inclusive possibilities in particular settings.

Objective:

This paper presents HarmonicThreads as a formative interaction-design case of a fabric-based digital musical instrument. The prototype explores how tactile cues, fabric deformation, projected visual feedback, and assisted accompaniment can support low-barrier …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Red Light Accelerates Adventitious Root Primordium Initiation And Differentiation In Phoebe Bournei Cuttings By Modulating Auxin Signaling And Hormonal Balance, Yuewang Niu, Yuanyang Bi, Chenyu Gong, Shipin Chen

Turkish Journal of Botany

Adventitious root formation in stem cuttings of Phoebe bournei, an economically and ecologically significant woody species, is a major bottleneck in clonal propagation. To elucidate the impact of spectral quality on early adventitious root development, we characterized the morphological, hormonal, and transcriptomic dynamics of primordium initiation and differentiation under white, red, and blue light. Under red light, cuttings exhibited the earliest and most pronounced formation of white filamentous structures at lenticels, indicative of root primordium initiation, as early as 20 days after cutting, whereas white and blue light treatments showed delayed responses. Paraffin section analysis confirmed the induced origin of …

Kenyon Collegian - September 3, 2026

The Kenyon Collegian

No abstract provided.

Modernizing And Clarifying Family Laws: The New Jersey Law Revision Commission’S Examination Of Self-Representation, Domestic Violence, And Parental Rights, Barbara B. Rivera, Whitney G. Schlimbach, Candy Ley Velazquez, Kyle M. Ryan

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Death: The Great Antagonist In Poe’S “The Cask Of Amontillado”, Majed S. Al-Lehaibi

Journal of Arts and Social Sciences

Poe’s story “The Cask of Amontillado” has been read as a story of a premeditated crime, of revenge and the protagonist’s ultimate pride in his well-executed crime. Readers are repulsed by the sheer evil of Montresor, the main character of the story. However, this paper argues that this reading barely scratches the surface of the depth and complexity of this story. It argues that the story is told in the form of a confession. The narrator, an elderly Montresor, is full of remorse, and in telling the story, he is seeking absolution. In its deeper meaning, “The Cask of Amontillado” …

Androgens Mediate Sexual Dimorphism In Pilarowski-Bjornsson Syndrome., Kimberley Jade Anderson, Eirny Tholl Thorolfsdottir, Ilana M. Nodelman, Sara Tholl Halldorsdottir, Stefania Benonisdottir, Malak A. Alghamdi, Naif A M Almontashiri, Brenda J. Barry, Matthias Begemann, Jacquelyn F. Britton, Sarah Burke, Benjamin Cogne, Ana S A Cohen, Carles De Diego Boguñá, Evan E. Eichler, Elizabeth C. Engle, Jill A. Fahrner, Laurence Faivre, Mélanie Fradin, Nico Fuhrmann, Christine W. Gao, Gunjan Garg, Dagmar Grečmalová, Mina Grippa, Jacqueline R. Harris, Kendra Hoekzema, Tova Hershkovitz, Sydney Hubbard, Katrien Janssens, Julie A. Jurgens, Stanislav Kmoch, Cordula Knopp, Meral Aktas Koptagel, Farah A. Ladha, Pablo Lapunzina, Tobias Lindau, Marije Meuwissen, Andreina Minicucci, Emily Neuhaus, Mathilde Nizon, Lenka Nosková, Kristen Park, Chirag Patel, Rolph Pfundt, Pankaj Prasun, Nils Rahner, Nathaniel H. Robin, Carey Ronspies, Jasmin Roohi, Jill Rosenfeld, Margarita Saenz, Carol J. Saunders, Zornitza Stark, Isabelle Thiffault, Sarah Thull, Danita Velasco, Clara Velmans, Jolijn Verseput, Antonio Vitobello, Tianyun Wang, Karin Weiss, Ingrid M. Wentzensen, Genay Pilarowski, Thor Eysteinsson, Madelyn Gillentine, Kári Stefánsson, Agnar Helgason, Gregory D. Bowman, Hans Tomas Bjornsson

Manuscripts, Articles, Book Chapters and Other Papers

Sex-specific penetrance in autosomal-dominant Mendelian conditions is largely understudied. The neurodevelopmental disorder Pilarowski-Bjornsson syndrome (PILBOS) was initially described in females. Here, we describe the clinical and genetic characteristics of the largest PILBOS cohort to date, showing that both sexes can exhibit PILBOS features, although males are overrepresented. A mouse model carrying a human-derived Chd1 missense variant (Chd1^R616Q/+) displays female-restricted phenotypes, including growth deficiency, anxiety, and hypotonia. Orchiectomy unmasks a growth-deficiency phenotype in male Chd1^R616Q/+ mice, while testosterone rescues the phenotype in females, implicating androgens in phenotype modulation. In the gnomAD and UK Biobank databases, rare missense variants …

Current State And Needs Of Clinical Laboratories In Selected Countries In Africa, Merih Tesfazghi, Anne E Tebo, Roa Harb, Anthony O Okorodudu, Lee Schroeder, Jeannette Guarner, Christine Bales, Jack Ladenson, Allison Targowski, Kerry Cosby, Olajumoke Oladipo

2020-Current year OA Pubs

The Africa Working Group, under the auspices of the Global Laboratory Quality Initiative of the Association for Diagnostics & Laboratory Medicine (ADLM), conducted several educational workshops in Africa to promote laboratory quality in the region. The challenges faced in maintaining quality in clinical laboratories in low-resource countries may differ from region to region and country to country. To better understand current gaps and inform our engagement with partners in Africa, a needs assessment survey was distributed to 1427 ADLM members in Africa and further disseminated through local partners, resulting in 121 responses from participants across 8 countries in the region. …

Complementary Vertebrate Wac Models Exhibit Phenotypes Relevant To Desanto-Shinawi Syndrome, Kang-Han Lee, Marwan Shinawi, Et Al.

2020-Current year OA Pubs

Monogenic syndromes are associated with neurodevelopmental changes that result in cognitive impairments and neurobehavioral phenotypes, including autism and seizures. Limited studies and resources are available to make meaningful headway into the underlying molecular mechanisms that result in these symptoms. One such example is DeSanto-Shinawi Syndrome (DESSH), a rare disorder caused by pathogenic variants in the

Artificial Intelligence In Food Engineering For Food Safety, Quality Assurance, And Human Health, Ayad Abbood Abdulhasan, A. M. Mustafa, F. F. Sayyid, Marwan B. Hussein, Mohanad Muzahem Khalaf

AUIQ Technical Engineering Science

Artificial intelligence (AI) is increasingly reshaping food engineering by providing data-driven tools for safeguarding food safety, ensuring quality assurance, and improving human health outcomes. This review synthesizes current evidence on the application of machine learning, deep learning, computer vision, and the Internet of Things (IoT) across the food production continuum, from raw material inspection to consumer-facing nutrition guidance. We examine how convolutional neural networks, hyperspectral imaging, and sensor-fusion approaches enable rapid, non-destructive detection of contaminants and pathogens, and how predictive models support shelf-life estimation and quality grading. We further discuss AI-enabled traceability systems, including blockchain-integrated supply chains, and the growing …

Edge Computing-Enabled Secure Federated Learning For Anomaly Detection In Industrial Iot Sensor Streams, Wijdan Noaman Marzoog Al Mukhtar

AUIQ Technical Engineering Science

The rise of the Industrial IoT (IIoT) will result in a surge of IIoT devices with high-velocity data streams requiring rapid, real-time analysis of these data streams to power predictive maintenance and assure cybersecurity. Centralized cloud-based approaches to anomaly detection are hindered by their inherent latency and privacy issues while independent or stand-alone approaches to edge-based anomaly detection do not have enough data to effectively detect anomalies. This paper presents a federated learning framework to collaboratively develop an anomaly detection model from multiple edge nodes, without sharing the raw sensor data, so that data sovereignty is preserved. Two major contributions …

On The Existence, Uniqueness And Stability Of Solutions Of Sdes With State-Dependent Variable Exponent, Mustafa Avci

Journal of Stochastic Analysis

We study a time-inhomogeneous nonlinear SDE with drift and diffusion governed by state-dependent variable exponents. This framework generalizes models like the geometric Brownian motion (GBM) and the constant elasticity of variance (CEV), offering flexibility to capture complex dynamics while posing analytical challenges. Using a fixed-point approach, we prove existence and uniqueness, analyze higher-order moments, derive asymptotic estimates, and assess stability. Finally, we illustrate an application where Poisson’s equation admits a probabilistic representation via a timehomogeneous nonlinear SDE with state-dependent variable exponents.

Enteral Nutrition Practices During Non-Invasive Ventilation In Critically Ill Children: Secondary Analysis Of The Niv Dex En Study, Charlene P. Pringle, Peter Chang, Joie Cavazos, Tristan Dorn, Christine Allen, K. Leslie Avery, Torrey Baines, Samantha Gee, Nekaiya Jacobs, Jodi J. Bloxham, Elizabeth M. Brothers, Elizabeth Elliott, Shannon Faulkinberry, Emily F. Goldhar, Stephanie C. Hsu, K. Meghan Kendall, Christine Koshel, Ada T. Lin, Kristin K. Magner, Krishna S. Siruguppa, Kitman Wai, Anna Wanzenberg, Ann-Marie Brown

Journal of Pediatric Intensive Care

Introduction: Despite the widespread use of non-invasive ventilation (NIV) in pediatric intensive care units (PICUs), little has been published regarding enteral nutrition (EN) in this setting. This pre-planned secondary analysis of the Association of Enteral Nutrition and Dexmedetomidine Usage for Critically Ill Children Requiring Non-Invasive Ventilation study aimed to describe current feeding practices during NIV in a large sample, including differences in timing, energy and protein delivery across NIV modes and interfaces. Methods: Secondary analysis of a retrospective study of 1763 patients acutely supported with NIV over one year in fourteen PICUs in the United States. Results: 1065 subjects (60.4%) …

Iatrogenic Withdrawal Syndrome In Critically Ill Neonates: A Review Of Mechanisms, Assessment, Management, And Prevention, Isaque Nilton Dos Santos, Carolina Teixeira Goulart Peano, Ericks Sousa Soares, Helena Iturvides Cimarosti

Journal of Pediatric Intensive Care

Considering that neonatal pain is a relevant matter given its implications and consequences, many neonates, particularly those undergoing critical care, are subjected to analgo-sedation therapies, which commonly include treatment with opioids and benzodiazepines. These drugs, however, can induce tolerance and dependency, leading to the development of the so-called iatrogenic withdrawal syndrome (IWS) which is observed following discontinuation of these therapeutic agents particularly when utilized for a prolonged period of time (>= 5 days). IWS consists of signs and symptoms manifested especially in young children, such as term and premature newborns in the neonatal intensive care unit (NICU), who are …

Regenerative Tourism And Transformative Destination Management: Developing A Framework Through The Case Of County Offaly, Yi (Alex) Yu, Mary Loonam Dr, Tony Johnston

Irish Journal of Tourism, Hospitality, Leisure and Event Research

The increasing urgency of climate change, biodiversity loss, and socio-economic transition has generated growing interest in tourism approaches that move beyond sustainability towards more transformative forms of development. While sustainable tourism has become the dominant paradigm within tourism planning and policy, it has been criticised for its emphasis on impact mitigation and its limited capacity to address systemic challenges. In response, regenerative tourism has emerged as an alternative framework that seeks to restore and enhance ecological, social, cultural, and economic systems through tourism activity.

This paper explores the potential of regenerative tourism as a framework for transformative destination management. Drawing …