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2026

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Primary Cutaneous High-Grade Extra-Skeletal Osteosarcoma: A Rare Case Report, Pauline Xu Jun 2026

Primary Cutaneous High-Grade Extra-Skeletal Osteosarcoma: A Rare Case Report, Pauline Xu

Graduate Medical Education Research Journal

NA


Dupilumab-Associated Mycosis Fungoides: Unmasked, Direct Effect, Or A Lymphoid Reaction?, Pauline Xu Jun 2026

Dupilumab-Associated Mycosis Fungoides: Unmasked, Direct Effect, Or A Lymphoid Reaction?, Pauline Xu

Graduate Medical Education Research Journal

NA


Beyond Pituitary Neuroendocrine Tumors: Spectrum Of 1101 Sellar/Suprasellar Region Masses In A Tertiary Referral Center In 36 Years, Lili Guo Jun 2026

Beyond Pituitary Neuroendocrine Tumors: Spectrum Of 1101 Sellar/Suprasellar Region Masses In A Tertiary Referral Center In 36 Years, Lili Guo

Graduate Medical Education Research Journal

NA


Determinants Of Early Mortality After Congenital Heart Surgery: A 7-Year Single-Center Experience In Saudi Arabia, Saud Abdulaziz Bahaidarah, Jowana Mahmoud Aljinaid, Amal Ahmad Alzahrani, Jana Mohammad Banjer, Lujain Abdulsalam Kofiyah, Nesmah Amin Noaman, Rahaf Adel Badkook, Raghad Abdulaziz Aljabri, Raghad Saeed Alghamdi, Renad Mohammed Alamoudi, Sarah Salem Bawazir, Gaser Abdelmohsen Abdelmohsen Jun 2026

Determinants Of Early Mortality After Congenital Heart Surgery: A 7-Year Single-Center Experience In Saudi Arabia, Saud Abdulaziz Bahaidarah, Jowana Mahmoud Aljinaid, Amal Ahmad Alzahrani, Jana Mohammad Banjer, Lujain Abdulsalam Kofiyah, Nesmah Amin Noaman, Rahaf Adel Badkook, Raghad Abdulaziz Aljabri, Raghad Saeed Alghamdi, Renad Mohammed Alamoudi, Sarah Salem Bawazir, Gaser Abdelmohsen Abdelmohsen

Journal of the Saudi Heart Association

Objectives:

To determine predictors of early mortality among pediatric patients undergoing congenital heart surgery at a tertiary care center in Saudi Arabia.

Methods:

This retrospective cohort study included 955 pediatric patients who underwent congenital heart surgery at King Abdulaziz University Hospital, Jeddah, between January 2017 and December 2023. Demographic, clinical, operative, and postoperative variables were collected.

Results:

Overall mortality was 4.9%. Mortality was higher among neonates and infants and among patients with RACHS categories 4–6. Non-survivors had longer cardiopulmonary bypass times and more frequent delayed chest closure. Postoperative complications, including the need for extracorporeal membrane oxygenation (ECMO), depressed cardiac function, …


The Impact Of Fear Of Aging On Luxury Consumption Among Middle-Aged Women, Jiyeon Lee, Xiaofei Wu, Dongwoo Ko Jun 2026

The Impact Of Fear Of Aging On Luxury Consumption Among Middle-Aged Women, Jiyeon Lee, Xiaofei Wu, Dongwoo Ko

Asia Marketing Journal

This study investigates the relationship between fear of aging and luxury consumption behaviors among middle-aged women, focusing on the psychological and social dimensions of aging anxiety. Utilizing frameworks such as Objectification Theory and the Double Standard of Aging, the research explores how aging anxiety impacts attitudes toward luxury goods, mediated by fear of negative evaluation and body esteem. A survey of 288 women aged 41 to 60 was conducted, revealing that fear of aging significantly influences luxury attitudes and purchasing intentions. Findings indicate that luxury goods are seen not only as tools for status maintenance but also as avenues for …


Impact Of Central Nervous System Infection Prediction Algorithms On Discordant Meningitis Encephalitis Panel And Culture Results In Children, Rose Mccoy Jun 2026

Impact Of Central Nervous System Infection Prediction Algorithms On Discordant Meningitis Encephalitis Panel And Culture Results In Children, Rose Mccoy

Graduate Medical Education Research Journal

NA


Evaluation Of Zap-70 Inhibition In The Prevention Of Leukemia Cell Migration Into The Central Nervous System (Cns), Mark Westbroek Jun 2026

Evaluation Of Zap-70 Inhibition In The Prevention Of Leukemia Cell Migration Into The Central Nervous System (Cns), Mark Westbroek

Graduate Medical Education Research Journal

NA


A Case Of Post-Transplant Lymphoproliferative Disorder 10 Years After Renal Transplantation, Carlos Izarra Boscan Jun 2026

A Case Of Post-Transplant Lymphoproliferative Disorder 10 Years After Renal Transplantation, Carlos Izarra Boscan

Graduate Medical Education Research Journal

NA


Nevus Lipomatosus Superficialis: A Rare Benign Skin Lesion – A Case Report, Adeyinka Aladejare Jun 2026

Nevus Lipomatosus Superficialis: A Rare Benign Skin Lesion – A Case Report, Adeyinka Aladejare

Graduate Medical Education Research Journal

NA


Facilitating Living Kidney Donation: Retrospective Evaluation Of Weight Loss Interventions To Support Kidney Donation, Julia Dumitrescu, Roslyn Mannon, Scott Westphal, Ashley Brabec, Regina Rau, Amy Olsen, Taylor Cidlik Jun 2026

Facilitating Living Kidney Donation: Retrospective Evaluation Of Weight Loss Interventions To Support Kidney Donation, Julia Dumitrescu, Roslyn Mannon, Scott Westphal, Ashley Brabec, Regina Rau, Amy Olsen, Taylor Cidlik

Graduate Medical Education Research Journal

Background. Living kidney donor transplantation provides recipients with kidney failure with an excellent graft function and survival. Donation of a kidney entails a thorough medical and psychosocial evaluation. Obesity is an increasingly prevalent medical condition and a known risk factor for the development of chronic kidney disease post-donation. Accepting overweight and obese individuals as living kidney donors remains controversial. The purpose of this study was to review the impact of obesity on the determination of candidates for living kidney donation at a single transplant center.

Methods. We performed a retrospective chart review of living kidney donors evaluated over 5 …


Snap Challenge In Teacher Education, Eric Hogan, Sean Forbes, Carey E. Andrzejewski Jun 2026

Snap Challenge In Teacher Education, Eric Hogan, Sean Forbes, Carey E. Andrzejewski

Journal on Empowering Teaching Excellence

Access the online Pressbooks version of this article here.

Training pre-service teachers often focuses on educating them about issues they will see in their own classrooms. One such issue is food insecurity. Food insecurity is defined by limited or uncertain access to nutritionally adequate and safe foods or the ability to acquire acceptable foods in socially acceptable ways (Rabbitt et al., 2023a). This article focuses on pre-service teachers' experiences while engaging in the SNAP Challenge to learn more about food insecurity while also learning how food impacts student learning and motivation. Participants in the study discussed how living off the …


Exercise-Induced Gene Expression Profiles In Adults With Obesity: A Systematic Review Of Molecular Adaptation, Brandon Galvan, Luis Alberto Flores, Flor Isela Torres-Rojo, Natanael Cervantes-Hernández, Cinthia Verónica Villegas-Balderrama, Liliana Aracely Enríquez-Del-Castillo Jun 2026

Exercise-Induced Gene Expression Profiles In Adults With Obesity: A Systematic Review Of Molecular Adaptation, Brandon Galvan, Luis Alberto Flores, Flor Isela Torres-Rojo, Natanael Cervantes-Hernández, Cinthia Verónica Villegas-Balderrama, Liliana Aracely Enríquez-Del-Castillo

Baltic Journal of Health and Physical Activity

Background: Obesity is a multifactorial and chronic condition characterized by excess adiposity and systemic low-grade inflammation. Exercise exerts metabolic and anti-inflammatory effects partly mediated through gene expression modulation in skeletal muscle and adipose tissue. However, heterogeneous responses among obese individuals suggest that genetic and epigenetic mechanisms shape exercise adaptation. Objective: This systematic review aimed to identify the genes and molecular pathways modulated by physical exercise in adults with obesity, and to classify them according to their biological functions across different exercise modalities. Methods: Following PRISMA guidelines, randomized controlled trials were searched in PubMed, SpringerLink, Science Direct, Cochrane, LILACS, Web of …


Poetry As Performance: The Case For "Camp" In Catullus, Jasmine Patera Jun 2026

Poetry As Performance: The Case For "Camp" In Catullus, Jasmine Patera

Floodwall Magazine

No abstract provided.


Predator-Prey Dynamics: Exploration And Logistic Extension Of The Lotka-Volterra System, Amanda Maylath, Samuel Brensinger Jun 2026

Predator-Prey Dynamics: Exploration And Logistic Extension Of The Lotka-Volterra System, Amanda Maylath, Samuel Brensinger

Electronic Proceedings of Undergraduate Mathematics Day

The Lotka-Volterra system is a classic model of predator–prey interactions, capturing the interdependent growth and decline of two species. Using a dynamical systems approach, we identify fixed points, linearize the system via the Jacobian, and analyze phase space trajectories to determine stability and long-term behavior. This analysis provides insight into predator-prey dynamics without requiring explicit solutions. We further extend the model by incorporating a carrying capacity for the prey, reflecting more realistic population dynamics.


A Lineage Of Violence: Online Radicalization, The Great Replacement, And Far-Right Terrorism In The United States, 2011–2019, Kai Kawafuchi Jun 2026

A Lineage Of Violence: Online Radicalization, The Great Replacement, And Far-Right Terrorism In The United States, 2011–2019, Kai Kawafuchi

Voces Novae

No abstract provided.


The Open Wiki Of Electrochemical Methods (Owem): A Community-Driven Educational Resource, Anderson Fuller, Devin Rappleye Jun 2026

The Open Wiki Of Electrochemical Methods (Owem): A Community-Driven Educational Resource, Anderson Fuller, Devin Rappleye

Reviews, Analyses, and Instructional Studies in Electrochemistry (RAISE)

The traditional resources for learning electrochemical methods—textbooks, academic literature, and university coursework—remain essential but are limited in accessibility, update frequency, and practical usability. This paper introduces the Open Wiki of Electrochemical Methods (OWEM), an open-access, community-driven platform designed to complement these resources. OWEM organizes content into equations, definitions, methods, tutorials, and supplementary articles, with a heavy emphasis on experimental relevance. A case study on cyclic voltammetry demonstrates how OWEM consolidates foundational theory, lesser-known results, and practical guidance within a continuously maintainable framework to benefit the broader electrochemistry community.


A Case Report Of Mesalazine-Induced Pulmonary Injury In A Patient With Ulcerative Colitis, Vasileios Paraschou, Vasileios Papavasileiou, Ilektra Voulgareli, Vasilios Tzilas Jun 2026

A Case Report Of Mesalazine-Induced Pulmonary Injury In A Patient With Ulcerative Colitis, Vasileios Paraschou, Vasileios Papavasileiou, Ilektra Voulgareli, Vasilios Tzilas

HCA Healthcare Journal of Medicine

Introduction

Mesalazine (5-aminosalicylic acid) is widely used as a first-line therapy for ulcerative colitis (UC) due to its efficacy and safety profile. Rarely, it can cause pulmonary toxicity with variable clinical and radiologic manifestations, making diagnosis challenging.

Case Presentation

We report the case of a 52-year-old woman with UC who developed persistent fever and progressive exertional dyspnea following escalation of mesalazine dosage. Imaging revealed diffuse bilateral ground-glass opacities, while infectious and UC-related pulmonary causes were excluded. Pulmonary function testing demonstrated restriction and markedly reduced diffusing capacity. Following mesalazine discontinuation and initiation of corticosteroid therapy, the patient experienced rapid symptomatic, functional, …


Aspirational Mirrors: A Conceptual Model Of Alumni-Led Near-Peer Outreach For Precollege Engagement In Ocean Engineering, Habibi Palippui, Juswan Sade Jun 2026

Aspirational Mirrors: A Conceptual Model Of Alumni-Led Near-Peer Outreach For Precollege Engagement In Ocean Engineering, Habibi Palippui, Juswan Sade

Journal of Pre-College Engineering Education Research (J-PEER)

Precollege students in Indonesia, especially in rural and coastal regions, often lack exposure to engineering disciplines due to social, geographic, and informational barriers. This essay proposes a conceptual model of alumni-led near-peer outreach as an affective and culturally grounded mechanism to engage high school students in ocean engineering. Drawing from theories of social similarity, possible selves, and engineering identity, the model conceptualizes alumni as “aspirational mirrors” who influence students not merely through information but also through identification. The model outlines four primary mechanisms—social connection, narrative engagement, aspirational mirroring, and early identity activation—and also accounts for contextual variables such as school …


A Crisis For Utopia: Jameson, The Collective, And The Future Of World Literature, Trevor Jackson Jun 2026

A Crisis For Utopia: Jameson, The Collective, And The Future Of World Literature, Trevor Jackson

CLCWeb: Comparative Literature and Culture

Working with Fredric Jameson’s influential discussions of utopia and world literature, the essay suggests that the prospect of utopia is frightening and also possibly boring insofar as it threatens to drain away the already waning possibility of experience in a postmodern, globalized world. In this world, resentment of the present seems to go hand in hand with a nostalgia for a fictitious past, underscoring the difficulty of conceptualizing new social, cultural, and economic arrangements. Viewing world literature as a possible source of a new utopian thought, a utopia unlimited to its contemporary dystopian guises, the essay retraces Jameson’s pronouncements on …


Against Pleonexia: Auerbach, World Literature, And The End Of History, Simon During Jun 2026

Against Pleonexia: Auerbach, World Literature, And The End Of History, Simon During

CLCWeb: Comparative Literature and Culture

Erich Auerbach’s essay on world literature, written in the early postwar period, has become central to our understanding of the field. This essay contextualizes Auerbach on world literature by approaching it through his larger project, which it thinks about in relation to scholars rarely considered in this context. These scholars are the French literary historians and critics Hippolyte Taine and Remy de Gourmont, and the German historical sociologist Alexander Rüstow. To place Auerbach at an intersection of these very different figures turns out to be illuminating. It both enlarges our sense of him and helps us better understand why he …


A World Without Literature? Tagore’S Words For His Times And Ours, Salmoli Choudhuri Jun 2026

A World Without Literature? Tagore’S Words For His Times And Ours, Salmoli Choudhuri

CLCWeb: Comparative Literature and Culture

In 1907, Rabindranath Tagore delivered a lecture on world literature to an audience in Calcutta, the then capital of British India. Amid powerful and intersecting forces—colonialism and nationalism, industrial modernity and mass poverty—Tagore’s position on literature was neither disengaged nor defensive, insofar as he related it to the human condition and the capacity for world-making. Far from staking a representational claim to world literature on behalf of Indian or Bengali literature, I argue in this article, Tagore reconceptualized the idea from its earlier canonical formulation by Goethe. He departed from dominant nineteenth-century philosophies that conceived the world as a spatial—and …


Recent Advances In Phosphatidylinositol Phosphate Kinases (Pipks) And Their Inhibitors, Mengxia Sun, Jian Hu, Xuefei Huang Jun 2026

Recent Advances In Phosphatidylinositol Phosphate Kinases (Pipks) And Their Inhibitors, Mengxia Sun, Jian Hu, Xuefei Huang

BAU Journal - Science and Technology

Phosphatidylinositol phosphate kinases (PIPKs) are an important class of enzymes in humans, which produce lipid signaling molecules playing central roles in pathogenesis of diseases such as cancer, neurodegenerative diseases, and viral infection. Consequently, they are attracting increasing attention as drug targets for disease treatment. This review summarizes the functions of the PIPK family enzymes and highlights recent efforts on designing novel inhibitors against PIPKs. These advances are extensively discussed to stimulate interest in this field and promote further development of highly potent and selective inhibitors for innovative therapeutic applications.


Can Gingival Crevicular Fluid Help In Diagnosing Pulp Inflammation? A Systematic Review, Wael Kassamany, Roula Abiad Jun 2026

Can Gingival Crevicular Fluid Help In Diagnosing Pulp Inflammation? A Systematic Review, Wael Kassamany, Roula Abiad

BAU Journal - Science and Technology

This review aims to find if there’s a positive correlation between biological markers detected in human gingival crevicular fluid and pulp inflammation.

An electronic search of three databases; PubMed, EBSCOhost and Google Scholar was conducted using the keywords “tooth or teeth or pulp” AND “gingival crevice fluid or gingival crevicular fluid” for English articles published between the year 1990 and 2026. Information regarding study design, patients age range and gender distribution, sampling method used, types of biomarkers studied, assay test used, and key findings of each article were extracted and analyzed.

Biomarkers studied were substance P “SP”, neurokinin A “NKA”, …


Antioxidant And Anti-Hemolytic Capacities Of Eucalyptus Camaldulensis Leaves, Achwaa Chbib, Malak Mezher, Mohamad Nasser, Akram Hijazi, Mahmoud I. Khalil Jun 2026

Antioxidant And Anti-Hemolytic Capacities Of Eucalyptus Camaldulensis Leaves, Achwaa Chbib, Malak Mezher, Mohamad Nasser, Akram Hijazi, Mahmoud I. Khalil

BAU Journal - Science and Technology

The effects of medicinal plants on the prevention of many diseases are due to their chemical composition. Eucalyptus camaldulensis (E. camaldulensis) is a native tree in Australia. Its extracts and essential oils (EOs) are applicable in the domains of pharmaceuticals and medicine. This work determined the anti-hemolytic and antioxidant capacities of the ethanolic (EE), methanolic (ME), and aqueous (AE) extracts from the leaves of Lebanese E. camaldulensis.  The leaves of E. camaldulensis were extracted with ethanol, methanol, and water solvent. Qualitative phytochemical analyses were applied to reveal the compounds of these extracts. The Folin-Ciocalteau and Aluminum chloride …


Afforestation Strategies In Semi-Arid Mediterranean Ecosystems: Experimental Evidence From Chmistar, Lebanon, Ahmad Saker, Mohammad Saleh, Wael Mostafa, Safaa Baydoun, Jamilah Borjac, Dalia El-Badan Jun 2026

Afforestation Strategies In Semi-Arid Mediterranean Ecosystems: Experimental Evidence From Chmistar, Lebanon, Ahmad Saker, Mohammad Saleh, Wael Mostafa, Safaa Baydoun, Jamilah Borjac, Dalia El-Badan

BAU Journal - Science and Technology

The success rate of broadleaf tree growth in semi-arid Mediterranean environments is reduced in afforestation operations constrained by water scarcity, shallow soil depth, and intense competition from herbaceous vegetation. This study, conducted between 2022 and 2024 in Chmistar, East Lebanon, using a completely randomized block design, aimed to evaluate the impact of three planting broadleaf trees techniques (traditional digging pits , hoedad tools, and auger digging) and four effective vegetation control (herbicide application, mowing,  mulching, and no control) on the early growth of three native broadleaf tree species (Pistacia palaestina, Quercus calliprinos, and Quercus infectoria ).

The …


Master Project Architecture: Systems Engineering Framework For An Autonomous, Thermally Integrated, Relativistic Interstellar Platform, Christopher L. Eckes Jun 2026

Master Project Architecture: Systems Engineering Framework For An Autonomous, Thermally Integrated, Relativistic Interstellar Platform, Christopher L. Eckes

Defensive Publications Series

This technical disclosure presents the overarching design, interface standards, and operational lifecycle framework for the Autonomous Hive-Mind Sensor Probe (AHSP). The AHSP is a building-scale (60-meter length, approximately 500-metric-ton dry mass), non-biological, modular spacecraft chassis optimized for autonomous, multi-decade interstellar transit at relativistic velocities (\(0.05c - 0.1c\)).

By eliminating the severe mass, volume, and atmospheric shielding constraints associated with biological life-support systems, the AHSP architecture reallocates its structural mass budget to create an entirely unified, self-sustaining thermodynamic and computational ecosystem. This master architecture coordinates six highly integrated technical disclosures and one long-range theoretical supplement, establishing a non-siloed spaceflight platform where …


Analisis Biaya Standar Pelayanan Minimal (Spm) Kesehatan Menggunakan Aplikasi Siscobikes Di Tingkat Kabupaten/Kota Di Indonesia, Purwa K. Sucahya, Resi Natalia Turnip, Lemi Kurniawan, Bondan Wicaksono Adhi, Iwan Supriyadi, Ni’Matun Nurlaela Jun 2026

Analisis Biaya Standar Pelayanan Minimal (Spm) Kesehatan Menggunakan Aplikasi Siscobikes Di Tingkat Kabupaten/Kota Di Indonesia, Purwa K. Sucahya, Resi Natalia Turnip, Lemi Kurniawan, Bondan Wicaksono Adhi, Iwan Supriyadi, Ni’Matun Nurlaela

Jurnal Ekonomi Kesehatan Indonesia

This research investigates the capacity of the Siscobikes (Health Costing System) application to forecast the financial requirements for the execution of Minimum Service Standards (SPM) within Indonesia’s health sector at the district and city levels.. The study utilized cross-sectional data from 166 districts/cities to ascertain the projected health financing requirements and juxtaposed these estimates with the actual budgetary allocations. The results show that each district/city requires approximately IDR 16 billion annually for SPM. Districts require around IDR 17 billion annually, while cities require approximately IDR 13 billion. Substantial regional disparities are observed: Eastern Indonesia has the highest per capita needs …


Śaṅkha-Dvīpa And The Swahili Littoral: Reconstructing India–East Africa Contacts Before The Common Era, Narendra Vijayasimha Jun 2026

Śaṅkha-Dvīpa And The Swahili Littoral: Reconstructing India–East Africa Contacts Before The Common Era, Narendra Vijayasimha

Zamani: A Journal of African Historical Studies

This article is the first focused attempt to explore India–East Africa relationships in the Bronze Age and early Iron Age, approximately two to three millennia before the Common Era (3000–300 BCE) from a puranic perspective. While extensive scholarship exists on medieval and later Indo–African exchanges, the pre-Common Era period has remained underexplored. Drawing on Purāṇic cosmographies, Greco-Roman geographical accounts, African archaeology, and Indian Ocean trade studies, this research reconstructs possible networks of contact facilitated by monsoon navigation and long-distance exchange. Methodologically, the article integrates textual exegesis, comparative cosmography, and archaeological correlation. The findings suggest that Indian conceptions of Śaṅkha-dvīpa reflect …


Profil Biomarker Apolipoprotein B Dan Lipid Terhadap Skor Syntax Pada Pasien Sindrom Koroner Kronik, Muhammad Novran Chalik, Erwin Sukandi, Taufik Indrajaya, Ferry Usnizar, Syamsu Indra, Imran Saleh, Rukiah Chodilawati, Irfannuddin Irfannuddin Jun 2026

Profil Biomarker Apolipoprotein B Dan Lipid Terhadap Skor Syntax Pada Pasien Sindrom Koroner Kronik, Muhammad Novran Chalik, Erwin Sukandi, Taufik Indrajaya, Ferry Usnizar, Syamsu Indra, Imran Saleh, Rukiah Chodilawati, Irfannuddin Irfannuddin

Jurnal Penyakit Dalam Indonesia

Introduction. Apolipoproteins are structural components of plasma lipoproteins that are involved in lipoprotein metabolism and lipid transport, reflecting the number of circulating atherogenic particles. The degree of coronary artery stenosis can be assessed by calculating the Synergy between PCI with TAXUS/paclitaxel-eluting stent and Cardiac Surgery (SYNTAX) score, which is an angiographic scoring system used to evaluate the complexity of coronary artery lesions. This study aimed to investigate the profile of apolipoprotein B and lipids, as well as their correlation with the SYNTAX score in patients with chronic coronary syndrome.

Methods. An observational analytic study with a cross-sectional design …


Evaluation Of Il-17/Il-23 Axis In Iraqi Patients With Essential Hypertension, Fatima Jalal Ayez, Manal Mohammed Kadhim Jun 2026

Evaluation Of Il-17/Il-23 Axis In Iraqi Patients With Essential Hypertension, Fatima Jalal Ayez, Manal Mohammed Kadhim

Al-Qadisiyah Medical Journal

Background: Essential hypertension is a multifactorial disorder and a major global public health concern. Emerging evidence suggests that chronic low-grade inflammation plays a key role in its pathogenesis. The interleukin-17/interleukin-23 (IL-17/IL-23) axis has been identified as a critical inflammatory pathway linking immune activation to vascular dysfunction and elevated blood pressure. Aim of study: Evaluate the IL-17/IL-23 axis including the levels of IL-17A and IL-23 in patients with essential hypertension and to investigate their potential role as inflammatory biomarkers. Patients, Materials and Methods: A case-control study was conducted in Al-Diwaniyah Governorate, Iraq, from October 2025 to February 2026. The study …