Digital Commons Network^™

Assessment Of Anaerobic Co-Digestion Of High Strength Organic Feedstocks Diverted From Landfills, Sumaiya Sharmin

Electronic Theses and Dissertations

The increasing generation of high-strength organic wastes such as food waste and fats, oils, and grease (FOG) presents challenges for landfill capacity and waste management. Anaerobic co-digestion offers a sustainable alternative by converting these wastes into renewable energy and nutrient-rich digestate. This study evaluated the co-digestion performance of single fruit waste residuals and mixed food waste with wastewater sludge to identify substrate combinations that maximize methane production while maintaining process stability. Laboratory-scale batch experiments were conducted under mesophilic conditions using thickened waste activated sludge (TWAS) with varying proportions of food waste and co-substrates, including seaweed, aquatic weed, grease trap waste, …

Functionalization Of The Amine Group For Access To 4-Imidazolidinone-Sulfadiazine Hybrid Derivatives And Study Of Their Biological Activities, Sabaa A. Yousif, Rafid S. Dawood

Baghdad Science Journal

The work successfully synthesized twelve novel derivatives of 4-imidazolidinone bearing a sulfadiazine moiety using a one-pot reaction. This was done by condensation of sulfadiazine with twelve different aldehydes to afford the corresponding imines as intermediates, which were then followed by a cyclization reaction with glycine to furnish the desired products 1-12 in 56-85% yields. The structures of these products were identified by FT-IR and ¹H NMR spectroscopy. In addition, a number of the produced compounds demonstrated diverse antibacterial and antioxidant activities. In terms of the antibacterial activity, the compounds 1, 2, 3, 4, …

A New Numerical Approach For Solving Caputo-Fabrizio Fractional Differential Equations, Manoj Kumar

Baghdad Science Journal

In this paper, we present a novel numerical scheme for solving fractional-order differential equations of the form ^CFD_t^η ψ ( t ) = f( t,ψ ( t ) ),ψ ( 0 ) = ψ ₀,0 < η < 1,t∈[ 0,T ], where ^CFD_t^η denotes the Caputo-Fabrizio derivative operator. Further, we establish the stability and error analysis of the proposed scheme. We also extend this scheme for solving systems of fractional differential equations. Furthermore, we perform the several numerical simulations and present the results graphically. The obtained solutions are compared with those achieved through the well-known methods such as fractional Adams-Bashforth method and a new predictor-corrector method. It has been observed that the proposed method offers greater accuracy than these established methods. Hence, the proposed scheme can be utilized for the simulations of various fractional order differential equations, when the derivatives are considered in the Caputo-Fabrizio sense.

Methylene Blue Dye Removal In Aqueous Solution Using Synthesized Mncuo2 Nanocomposite: Thermodynamic And Kinetic Studies, Sara Mohammed Hassan, Ahlam M. Farhan

Baghdad Science Journal

This work reports the preparation of manganese and cupper Hybrid Oxide nanocomposites by a green synthesis method. The material was characterized by X-ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), and Transmission Electron Microscopy (TEM). Brunauer–Emmett–Teller (BET) surface area measurements The synthesized materials were examined for their dye adsorption performance through the removal of basic methylene blue (MB) as a model compound from water. Various adsorption parameters were investigated, such as adsorbent dosage, contact time, solution pH, and temperature. Mesoporous MnCuO₂ nanocomposites displayed satisfactory results, with rapid adsorption occurring and the use of low-concentration sorbents and contact times …

Synthesis, Spectroscopic Characterization, Biological And Computational Study For Some Metal Ions Complexes With Schiff - Mannich Base Ligand Derived From 1,3,4-Thiadiazole, Israa Rasheed Ghadhban, Shaymaa R. Baqer

Baghdad Science Journal

A new Schiff–Mannich base ligand derived from 1,3,4-thiadiazole was synthesized via the reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with sulfabenzamide and indoline in the presence of formaldehyde, yielding N–(4-((5-(2-oxoindolin-3-ylideneamino)-1,3,4-thiadiazol-2-ylthio)methylamino) phenyl thiolperoxy) benzamide (L). Six multivalent metal complexes were subsequently prepared with Co(II), Ni(II), Cu(II), Pd(II), Pt(IV), and Au(III) ions. The ligand and its complexes were characterized using various spectroscopic techniques, including FT-IR, UV-Vis, ¹H NMR, and ¹³C NMR, while magnetic susceptibility and conductivity measurements were performed for the complexes. Infrared analysis revealed tetradentate coordination of the ligand to all metals, with octahedral geometries for most complexes and square planar geometries for …

Synthesis, Characterization, Molecular Docking, And Anticancer Activity Of Triazole-Derived Trinuclear Metal Complexes (Tat3), Eman M. Ramadthan, Khansaa Shakir Al-Nama, Ammar H. Al-Sabawi

Baghdad Science Journal

A novel series of trinuclear coordination complexes of Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) was synthesized using a triazole-based ligand, namely 4-amino-5-((bis((4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)amino)methyl)-2H-1,2,4-triazole-3(4H)-thione, (TAT3) in an alcoholic medium. The obtained complexes were investigated using a comprehensive set of physicochemical and spectroscopic techniques, including CHNS elemental analysis, Fourier-transform infrared (FT-IR) spectroscopy, UV–visible spectroscopy, proton and carbon-13 nuclear magnetic resonance (¹H and ¹³C-NMR), mass spectrometry, magnetic susceptibility measurements, and molar conductivity. Structural and surface morphology assessments were further carried out using X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM). The spectroscopic and analytical data confirmed that …

Synthesis, Characterization, And Biological Evaluation Of A New Azo Dye Ligand 1-[2,4,6-Trihydroxy-3-(2-Hydroxy-Phenylazo)-Phenyl-Ethanone] And Its Complexes With Co(Ii), Ni(Ii), Cu(Ii), Zn(Ii), And Cd(Ii), Ban Hasan Al-Agele, Areej Kamal Assim Aldabbagh

Baghdad Science Journal

1-[2,4,6-trihydroxy-3-(2-hydroxy-phenylazo)-phenyl-ethanone] is a new azo dye ligand (H₂L), which was used to form a number of new azo dye-metal complexes by reaction with salt chlorides of Co, Ni, Cu, Zn and Cd(II). The complexes were characterized using mass spectroscopy, infrared analysis, ultraviolet-visible spectrophotometry, ¹H-, ¹³C-NMR spectroscopy, conductivity, magnetic susceptibility, DSC, TGA, C.H.N., metal content, and melting point. The results highlighted the ligand's trigonal behavior and that all the complexes yielded tetrahedral geometry, with the exception of Co and Ni, which produced octahedral geometry. They are all non-electrolytic. The compounds' capacity to function as antioxidants was used …

Investigation Of Radiation And Heavy Metal Hazards In Nutritional Supplements For Athletes, Sarah Amir Abdalabass, Ahmed Fadhil Mkhaiber

Baghdad Science Journal

Nutritional supplements are widely consumed worldwide. This study assesses uranium isotopes and radon concentrations in nutritional supplements using CR-39 detectors to evaluate potential radiological health risks. In addition, the concentrations of selected heavy metals were quantified using atomic absorption spectroscopy (AAS), The results indicated that the activity concentrations of uranium isotopes (U²³⁸, U²³⁵, and U²³⁴) were (6.07 ± 0.5 Bq/kg), (0.2 ± 0.02 Bq/kg), and (6.2 Bq/kg), respectively. The average total annual effective dose (AED) and the risk of excess fatal cancer per million population (RECFPMP) were (0.0006 ± 0.00005 mSv/y) and (2.2 ± …

Urban Climatic And Health Impacts Of Aerosols, Yuezhi Li

McKelvey School of Engineering Graduate Student Theses & Dissertations

Aerosols, also known as particulate matter (PM), strongly influence the climate and pose considerable risks to human health. As short-lived climate forcers, aerosols alter the Earth’s radiative budget by absorbing and scattering incident solar radiation, thereby affecting global and regional temperatures, atmospheric circulation, cloud formation, and precipitation patterns. From a public health perspective, exposure to particulate matter, particularly fine and ultrafine particles, has been associated with a wide range of adverse outcomes, including respiratory diseases, neurodegenerative disorders, and premature mortality. In addition, aerosols can transport pathogens and represent a critical pathway for the transmission of airborne infectious diseases. Despite contributing …

Investigating Light-Matter Interactions In Low-Dimensional Silicon Carbide, Nishan Shrestha

Mechanical Engineering ETDs

Recent advances in materials science have transformed the study and application of low-dimensional materials, with two-dimensional (2D) systems and nanoscale structures exhibiting properties beyond their bulk counterparts. Despite significant progress in materials such as graphene and silicon, the nanoscale exploration of silicon carbide (SiC) remains relatively underdeveloped, despite its critical importance in photonics and electronics and high temperature applications. Motivated by the transformative potential of nanoscale material design and the technological importance of SiC, this dissertation investigates structure and properties of low-dimensional silicon carbide structures. It explores the synthesis and optical properties of SiC nanosheets and nanowires using a variety …

Thermal Sensitivity Of Native And Introduced Crabs: Implications For Reproductive Success, Keria Moritsugu-Vandehey

Dissertations and Theses

Temperature is a major driver of physiological and developmental processes in marine organisms, and continued climate warming is expected to affect reproduction and recruitment in estuarine species. Early life stages are often particularly sensitive to environmental stress, yet relatively little is known about how warming influences embryonic development, hatching success, and larval survival across co-occurring native and introduced crab species.

This study examined the effects of temperature on embryonic development, hatching success, and early larval survival in four estuarine crab species from the Pacific Northwest: the introduced European green crab, Carcinus maenas, and the native shore crabs Hemigrapsus nudus …

Neural And Computational Mechanisms Of Effort Under The Pressure Of A Deadline, M. Andrea Pisauro, Daniele Pollicino, Lucy Fisher, Matthew A. J. Apps

School of Psychology

Deadlines fundamentally shape motivation. Research examining effort-based choices finds effort is an avoided cost. However, this overlooks how making progress on longer-term goals to be reached before deadlines motivate people to exert high effort for little immediate reward. Here, we test a framework where motivation depends on deadline pressure (work remaining / time remaining). Across four studies we use computational modelling examining decisions when physical effort makes progress on goals with deadlines. In support of the hypotheses, deadline pressure significantly impacts decision-making, shifting people from avoiding effort, to seeking the progress it makes. Using ultra-high-field fMRI, we show that functionally …

From Chromosomes To Precision Therapy: Clinical Cytogenetics And Cytogenomics In The Era Of Genomic Medicine, Jinglan Liu

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

No abstract provided.

Acalabrutinib Monotherapy As A First-Line Treatment For Cll: 3 Years Follow-Up Of The Real-World Epic Study: 3-Year Follow-Up Of The Real-World Epic Study, Toby A. Eyre, Nicolás Martínez-Calle, Shankara Paneesha, Mohsen Norouzi, David L Tucker, Harriet Sarah Walter, Alison Boden, Mari Kilner, Neil Phillips, Piers Em Patten, Nimish Shah, Meghna Ruparelia, Sharon Oddy, Tan Tsawayo, Francesco Forconi, Helen Wardle, Tobore Gbemre, Chris Gregory, Lucy B. M. Cook, David J Allsup, Anna Morris, Christopher J C Knechtli, Jenni Davies, Joy Galani, Helen Marr, Claire Hutchinson, Stella Williams, Joe Hickey, Hannah Harding, Sukhjit Hunjan

Peninsula Medical School

Clinical trials indicate that acalabrutinib, a second-generation Bruton tyrosine kinase inhibitor, is safe and effective for treating patients with chronic lymphocytic leukemia (CLL), but real-world evidence on its clinical effectiveness is limited. This ongoing multicenter retrospective chart review included UK adults with previously untreated CLL who received acalabrutinib monotherapy as part of a UK-wide early access program. These patients received their first dose of acalabrutinib between 1 April 2020 and 1 April 2021. Data from 282 patients (male patients, n = 156 [55%]) collected from 29 sites across the United Kingdom revealed a median age of 73.9 years (interquartile range …

Exploring The Nature And Role Of Local Cation Ordering In Disordered Rock Salt Cathodes For Li- And Na-Ion Batteries, You Wang

Chemistry and Chemical Biology ETDs

Cation-disordered rock-salt (DRX) cathodes provide a highly tunable platform for next-generation Li- and Na-ion batteries, but their electrochemical behavior is strongly influenced by local structural features hidden in average crystal structures. This dissertation systematically investigates local cation ordering in Li- and Na-based DRX cathodes to understand its effects on Li+/Na+ transport, redox activity, structural evolution, and electrochemical performance. In Li-based systems, Raman spectroscopy and electrochemical analysis reveal that local layered cation ordering in Mn- and Fe-based DRX cathodes is closely correlated with electrochemical behavior. Over-stoichiometric Li-based DRX oxyfluorides further demonstrate that excess Li can regulate local cation ordering, improve Li+ …

Multiscale Network Modeling Of Native And Modified Photosynthetic Light-Harvesting Complexes, Zane E. Armijo

Chemical and Biological Engineering ETDs

Photosynthetic light-harvesting complexes harvest solar energy and direct electronic excitations toward reaction centers with exceptional efficiency. This dissertation models the Fenna--Matthews--Olson complex of green sulfur bacteria, coupled to the PscA1 reaction center, as a chromophoric network. Forster resonance energy transfer theory, validated against numerically exact hierarchical equations of motion, was implemented in kinetic Monte Carlo simulations to resolve fine-grained excitation-transport pathways. The predicted charge-transfer efficiency of 77\% agrees with experiment, with the FMO2 monomer and its gateway pigment governing interfacial transfer. Systematic single, multi, and symmetry-preserving site removals, interpreted through Mobius inversion, identify critical pigments and show that cooperative effects …

Impact Of Gas Interactions With Nano Porous Geological Material In The Presence Of Water Vapor, Matthew D. Powell

Chemical and Biological Engineering ETDs

Predicting gas transport in nanoporous geological material requires understanding competitive adsorption and transport under humid conditions. However, most adsorption studies rely on single-component equilibrium measurements that do not capture these effects. This dissertation develops an experimental methodology to directly quantify multicomponent gas adsorption and breakthrough behavior under controlled relative humidity. The method was first applied to the Kr/Xe–N2–H2O system, where it resolved competitive adsorption behavior in humid porous media and produced a bivariate model relating noble gas adsorption to noble gas partial pressure and water saturation. The methodology was then extended to the CO2–N2 H2O system. Results showed that water …

Investigating Nanoparticle Capture By Condensed Phase Coacervates And Their Mixtures, Sanjna A. Bhakta

Chemical and Biological Engineering ETDs

The thermoresponsive polymers elastin-like polypeptides (ELPs) and poly(N-isopropylacrylamide) (PNIPAM) have served as a programmable bioseparation tool for applications in nanoparticle capture due to biocompatibility and tunable properties. This work investigates how the polymer composition of ELP and PNIPAM coacervates influences their phase behavior, structural morphology, and nanoparticle recruitment. In addition, the influence of interfacial interactions in nanoparticle recruitment using Tween 80 as a mechanistic probe was also investigated. Different mixtures of ELPs E1.40, E1.80, and E3 with PNIPAM14 and PNIPAM20 were used to characterize their phase behavior and analyze structural morphology using turbidity measurements and microscopy, respectively. Nanobead recruitment using …

Impacts Of Agricultural Microplastics On The Growth Of Marine Phytoplankton In Monterey Bay, Olivia A. Pawlyk

Master's Theses

Agricultural plastics are an emerging source of microplastics (MPs) to coastal marine environments, yet their effects on marine phytoplankton remain poorly understood. In coastal regions surrounding Monterey Bay (California, USA), plastic mulch used in agriculture can fragment into MPs during weathering and removal, entering marine waters via runoff and wind transport. This study investigated the effects of environmentally relevant concentrations of agricultural MPs on the growth and physiology of four marine phytoplankton species: two harmful algal bloom (HAB) taxa (Alexandrium sp. and Pseudo-nitzschia multiseries) and two non-HAB taxa (Thalassiosira sp. and Prorocentrum sp.). Each species was cultured independently and exposed …

Biologically-Based Alternatives To Plastic Mulch Enrich Microbiome And Buffer Yield In Small-Scale Strawberry Production, Olivia L. Fragiacomo

Master's Theses

Much of commercial agriculture has used plastic mulch since the 1950s to contain fungicides and fertilizers, control weeds, retain soil moisture, and warm the top soil to start the growing season earlier. Research suggests that small-scale strawberry (Fragaria x ananassa) growers may be able to incorporate biological techniques, such as wheat straw mulch with microbial amendments, to reduce the use of single-use plastic mulch with a comparable yield. For this study, I carried out a randomized complete block comparison of five strawberry management techniques: plastic mulch (PM), straw mulch alone, and straw mulch inoculated with either arbuscular mycorrhizal fungi (AMF), …

Borderline Personality Disorder (Bpd) And Witness Memory: A Beginner’S Guide For Criminal Justice, Forensic Mental Health, And Legal Professionals, Jerrod Brown Ph.D., M.A., M.S., M.S., M.S.

Forensic Scholars Today

Borderline personality disorder (BPD) is associated with emotional instability, impulsivity, interpersonal difficulties, identity disturbance, and stress-related dissociative symptoms that may influence cognitive functioning. Research suggests that BPD may contribute to difficulties with attention, executive functioning, and memory, particularly during periods of emotional distress. These issues, combined with common co-occurring conditions such as trauma exposure, substance use disorders, and sleep disturbances, may affect the encoding, storage, retrieval, and recall of information. This article examines current literature on BPD and discusses how symptoms and associated factors could influence witness memory in forensic and legal settings. Because findings remain mixed, the presence of …

Behavioral Analysis Of Cryptoprocta Ferox At The Central Florida Zoo And Botanical Gardens, Rita R. Albert

The Pegasus Review: UCF Undergraduate Research Journal

The fossa, Cryptoprocta ferox, is the largest carnivorous mammal endemic to the island of Madagascar. C. ferox is currently listed as a vulnerable species by the IUCN Red List (2015) due to deforestation. Most fossas are now located in zoos for breeding and repopulation purposes, but research on captive mating has been limited due to the low numbers of successful breeding attempts in captivity. The Central Florida Zoo and Botanical Gardens is home to two fossas, one male and one newly introduced female. This study notes behavioral changes in captive mating fossas, with a focus on the male fossa …

A Hybrid Deep Learning Model Combining Cnn And Extreme Learning Machine For Cyberattack Classification, Israa S. Kamil

Journal of Intelligent Informatics, Networking, and Cybersecurity

As ransomware attacks and zero-day exploits grow sophisticated, the need for intelligent, accurate systems to detect such threats becomes clearer. In this paper, a hybrid learning model based on Convolutional Neural Networks (CNNs) and Extreme Learning Machine (ELM) is presented to improve multiclass classification performance for cybersecurity applications. The framework combines CNNs' hierarchical feature learning with ELMs' fast classification. An attention mechanism that assigns weights to each feature based on importance is included in the final model. The hybrid model performed well on the metrics: precision = 0.97, recall = 0.98, and F1- score = 0.97, and, as expected from …

Beyond Histone Demethylation: Mechanisms Of N‑Alkyl Consecutive Oxidations By The Non-Heme Fe(Ii)/2-Oxoglutarate Oxygenase Kdm6b, Simahudeen Bathir Jaber Sathik Rifayee, Sudheesh Devadas, Midhun George Thomas, Bhargav Varada, Ethan Sommer, Cassandra Talaba, Christopher Schofield, Christo Christov

Michigan Tech Publications

The nonheme Fe-(II)/2-oxoglutarate (2OG)-dependent histone demethylase KDM6B (JMJD3) has demonstrated a capacity for diversity in the oxidative transformations of N-alkylated lysine residues in histone H3 peptides; however, the mechanisms of such dealkylations, compared with standard KDM-catalyzed demethylations, remain unexplored. We implemented molecular dynamics and quantum mechanics/molecular mechanics to investigate the catalytic strategies for the sequential oxidation reactions of KDM6B with different N-alkylated forms of lysine K27 in the H3 peptide chain, that is N , N -methyl ethyl lysine () and N -isopropyl lysine (). The results for sequential oxidations, which yield alcohol, aldehyde, and then carboxylic acid products, reveal …

Stop Blaming My Users: Illumination Of The Technocentric Mythos Bias, Ervin H. Frenzel, Richard Lightcap

Journal of Cybersecurity Education, Research and Practice

 Abstract -This conceptual essay addresses the need for systemic and systematic transdisciplinary analytical techniques within cybersecurity and technical security. This conceptual essay is contingent upon recognition that cybersecurity is not simply technical in nature, it does not need an adversary, and more importantly it is based upon systems engineering and systems thinking.  The essay contributes a socio-technical attribution chain and field-specific ontology/taxonomy which distinguish user-triggered events from root causes, latent conditions, technical debt, validation failures, governance failures, and attribution bias before assigning responsibility to end users. It systematically defines an ontology inclusive of developer technical debt, organizational debt arising from …

Toxic Relationships: Characterization Of A Putative Virally Encoded Toxin In The Thermophilic Archaeal Fusellovirus Ssv1, Jonathan C. Abshier, Patrizia L. Alpapara, Guasåli Tomokane, Kenneth M. Stedman

Center for Life in Extreme Environments Publications

Mechanisms for the maintenance of chronic viruses are poorly understood, particularly for archaeal viruses. Here, we identify the product of Sulfolobus spindle-shaped virus 1 (SSV1) ORF a291 as a putative virally encoded toxin required for growth inhibition but dispensable for viral replication and virion production. Viruses lacking ORF a291 replicated their genomes and formed morphologically normal spindle-shaped particles, yet failed to inhibit the growth of uninfected Saccharolobus solfataricus. Substitution of residues at a predicted N-terminal signal peptide cleavage site abolished growth suppression without affecting replication, suggesting that secretion is essential for toxin function. Despite primary sequence divergence among fusellovirus …

Micro-Computed Tomography Analysis Of Fibroblast Growth Factor-2 Activity-Induced Healing Of Dentocraniofacial Bones In Rodent Models: A Systematic Review, Fadhlil Ua. Rahman, Azhari Azhari, Lusi Epsilawati, Ria N. Firman, Barunawaty Yunus, Irfan Sugianto, Muliaty Yunus

Journal of Dentomaxillofacial Science

Objective: This study aimed to assess the impact of fibroblast growth factor-2 (FGF-2) on dentocraniofacial bone healing in rodent models using micro-computed tomography (micro-CT).

Materials and Methods: A systematic review was conducted following PRISMA 2020 guidelines. A literature search was conducted using the PubMed, Embase, Web of Science, ScienceDirect, and Wiley Online Library databases. This review included in vivo rodent studies that examined increased FGF-2 activity in craniofacial bones using micro-CT. Methodological quality and risk of bias were assessed using the ARRIVE 2.0 guidelines and the Systematic Review Center for Laboratory Animal Experimentation tool.

Results: A total of 5 studies …

Looking Inwards, Turning Away: A Review Of Rehan Abeyratne’S ‘Courts And Lgbtq+ Rights In An Age Of Judicial Retrenchment’, Jwalika Balaji

Socio-Legal Review

This review engages with Rehan Abeyratne's book Courts and LGBTQ+ Rights in an Age of Judicial Retrenchment, which examines judicial responses to LGBTQ+ claims over the past two decades across three jurisdictions — the United States, India, and Hong Kong. Abeyratne argues that the apex courts in these countries have grown more inward-looking and have enabled the rise of illiberal and authoritarian forces; however, LGBTQ+ rights have emerged as an exceptional site where these courts continue to extend minimal remedies and adopt a tone of empathy, positioning themselves as the last bastion of liberal constitutionalism. Focusing on recent developments …

Bureaucratic Politics Of Reforestation In Indonesia's Conservation Areas: Turf Protection, Competing Mandates, And Implementation Deadlocks, Arief Setiyo Utomo, Pande Made Kutanegara, Ahmad Maryudi

Forest and Society

In response to extensive deforestation and land degradation, the Indonesian government has made reforestation one of its top policy priorities. Although several reforestation programs have been implemented, their outcomes have often been constrained by governance-related challenges. This study examines the political dynamics of reforestation in conservation areas by analyzing interactions between two key bureaucracies within the Ministry of Forestry: the Directorate General of Watershed Management and Forest Rehabilitation (DG-WMFR) and the Directorate General of Natural Resources and Ecosystem Conservation (DG-NREC). Drawing on the bureaucratic politics perspective, we show how competing mandates, organizational interests, and bureaucratic turf protection motives shape the …

Genetic Associations With Pulmonary Embolism Among Those With A Deep Vein Thrombosis: The International Network Against Venous Thrombosis Consortium, Susana Lozano-Esparza, Gabrielle E Shakt, Jennifer A Brody, Angel Martinez-Perez, Matthew P Conomos, Marine Germain, Katharine R Clapham, Maris Teder-Laving, Astrid Van Hylckama Vlieg, Anni Kauko, Florian Thibord, Ohanna C L Bezerra, Girish N Nadkarni, Gaëlle Munsch, Therese Haugdahl Nøst, Ellen L Goode, Yuekai Ji, Daniel I Chasman, Alexander P Reiner, Constance Turman, Kerri L Wiggins, Colleen M Sitlani, Juan Carlos Souto, Pamela L Lutsey, Tiffany Bellomo, Estonian Biobank, Million Veteran Program, Ruifang Li-Gao, Aleksi Kristian Winstén, Ming-Huei Chen, Ron Do, Lénaick Gourhant, Kristian Hveem, Sebastian M Armasu, Noémie Saut, Nathan Pankratz, Franco Giulianini, Jeffrey Haessler, Mingyang Song, Robert Olaso, Eric Boerwinkle, Daniel Dochtermann, Jose Manuel Soria, Stephen S Rich, David Smadja, Satoshi Koyama, Frits R Rosendaal, Teemu Niiranen, France Gagnon, Ha My T Vy, Neil Zakai, Catherine Lemarie, Anne Heidi Skogholt, Jean-François Deleuze, James S Pankow, Paul M Ridker, Yuxi Liu, Kenneth M Rice, Saiju Pyarajan, Mary Cushman, Jospeh Emmerich, Bruce M Psaty, Pradeep Natarajan, Andrew D Johnson, Marc A Rodger, Pierre Suchon, Francis Couturaud, Pierre-Emmanuel Morange, Weihong Tang, Charles Kooperberg, Christopher Kabrhel, Maria Sabater-Lleal, David-Alexandre Trégouët, Alisa S Wolberg, Scott M Damrauer, Nicholas L Smith

Children’s Nutrition Research Center Staff Publications

Background: Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE), the latter of which often originates from DVT and can be fatal.

Objectives: The aim of this study was to identify causal genetic factors that alter risk of PE among those with a presumed DVT.

Methods: Using a case-only design of VTE, we conducted meta-analyses of genome-wide association studies (GWASs) in the International Network Against Venous Thrombosis Consortium. Among participants diagnosed with VTE, each study identified those who had a clinically reported PE, with or without a clinically reported DVT; those remaining had isolated DVT. Logistic regression …