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Mapping Coastal Vegetation To Evaluate Salt Marsh Decline From 2016 To 2025 In South Carolina, Usa, Zak Henry Bartholomew

Theses, Dissertations and Capstones

Accelerating sea-level rise and storm surge events pose a substantial threat to salt marsh ecosystems, which provide critical ecosystem services. Classification and mapping of coastal vegetation through remote sensing can identify marsh dieback events and provide spatial context for patterns of marsh vulnerability. We used a multi-sensor approach that incorporated LiDAR data, multispectral imagery, and field-derived cover estimates to classify Spartina alterniflora (smooth cordgrass) dominated marsh types on Marine Corps Recruit Depot Parris Island (MCRDPI), a sea island in South Carolina, USA. In summer 2025, surveys were conducted within marsh classes to collect training and validation data. We used random …

Do Magnesium Ions Have Similar Effects As Calcium Ions On Resting Membrane Potential?, Anthony Hana, Youngwoo Kim, Joy Bidros, Katie Neglia, Robin L. Cooper

Biology Faculty Publications

Maintaining a membrane electrical potential of biological cells is a dynamic process, as some cells have a continually changing potential, like pacemaker cells, while other cells may function with large or small changes in the membrane potential. Additionally, some cells may change their electrical potential when stimulated or inhibited by electrical signals, chemical compounds, or both—either simultaneously or episodically. The persistent leak of K⁺ through two-pore-domain potassium channels (K2P) and of Na⁺ through Na⁺ leak channels (NALCNs) and the action of pumps and exchangers are primarily responsible for maintaining a resting potential. Ca²⁺ ions are known …

An Evolving View Of Lineage Diversification, Pascal O. Title, L. Francisco Henao-Díaz, Rosana Zenil-Ferguson, Thais Vasconcelos

Biology Faculty Publications

Systematists have long been fascinated by the astounding variation in species diversity across the various branches of the tree of life, a net result of the uneven rates at which lineages undergo speciation and extinction over time. The past 30 years have seen the development and widespread application of tools that allow diversification to be quantified and characterized in empirical data sets. These advances have, in turn, enabled the statistical evaluation of hypotheses about the causes behind the uneven distribution of species richness among lineages, leading to a more nuanced understanding of diversification rate variation, as reflected in an ever-expanding …

Exogenous Estradiol Does Not Regulate Daily Metabolic Rhythms Underlying Diet-Induced Obesity In Male Mice, W. Brad Osborne, Oliver Vöcking, Victoria Alvord, Oluwabukola Omotola, Yuriko Katsumata, Julie S. Pendergast

Biology Faculty Publications

Male mice fed high-fat diet become obese, but female mice are resistant to diet-induced weight gain. We previously found that circulating estradiol in females protects their daily rhythms from disruption by high-fat feeding to prevent diet-induced obesity. The goal of this study was to determine the effects of estradiol on daily metabolic rhythms in male mice. Male C57BL/6J mice were treated with estradiol and fed high-fat diet for 2 weeks. We measured the effects of high-fat diet feeding on daily rhythms of eating behavior and locomotor activity, and on the phases, or timing, of circadian rhythms in central and peripheral …

Drinking Microstructure Analysis Of Direct Controls Of Water Intake In Male And Female Rats, Bo W. Sortman, Emalie L. Mullane, Kennedy L. Lamb, Andrea A. Edwards, Ann-Marie Torregrossa, Derek Daniels, Jessica Santollo

Biology Faculty Publications

Measures of rodent drinking (lick) patterns are used to test how various manipulations affect fluid intake. Decades of research indicate that manipulating the satiating potency of a stimulus affects the number of licking bursts whereas manipulating the hedonic value of the solution affects the size of the licking bursts or rate of licking. This type of analysis has been largely applied to manipulations that modulate drinking that is already occurring (i.e., indirect controls or modulators of intake), but there is a dearth of studies with detailed measures of licking due to stimuli that are primary drivers of intake which happen …

Expressing Experiences Of Being Gender Non-Conforming In The “Ladies” Restroom Through Autoethnography-Based Research Poetics, Ellen D.B. Riggle

Gender and Women's Studies Faculty Publications

Three research poems are created as an autoethnographic response to feedback on a research article on the author’s experiences as a gender non-conforming person in women’s public restrooms. The feedback loop includes the sharing of lived experiences by others and theoretical (why?) discussions in the context of the gendered policing and politicalization of women’s restrooms. The first found poem includes words, phrases, and descriptions of images used to label spaces designated as women’s restrooms. The second prose poem recounts the author's experiences through a reframing of risk to women’s health, understanding the cultural context of male entitlement and White supremacy, …

Unlocking The Power Of Cxcr2 Inhibition To Overcome Gemcitabine Resistance In Pancreatic Cancer, Caitlin Molczyk, Reegan Sturgeon, Sugandha Saxena, Esther Johnson, Rakesh Bhatia, Namita Bhyravbhatla, Sushil Kumar, Surinder K. Batra, Rakesh K. Singh

Journal Articles: Biochemistry & Molecular Biology

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality, characterized by intrinsic resistance to conventional therapies and limited effective treatment options. In this study, we investigated the role of the CXCR2 axis in PDAC therapy resistance. CXCR2, a chemokine receptor, is actively involved in inflammation, tumor angiogenesis, and metastasis. Our working hypothesis is that CXCR2 contributes to PDAC chemotherapy resistance. To test this, we generated gemcitabine-resistant (GemR) lines using T3M4 and CD18/HPAF (CD18) cell lines. Baseline expression of CXCL1, CXCL5, and CXCL8 ligands was higher in GemR cells compared to parental cells. Upon gemcitabine treatment, parental cells …

Midkine (Mdk) As A Central Regulator Of The Tumor Microenvironment: From Developmental Cytokine To Therapeutic Target, Hareesh B. Nair, Ajay Nair, Ya-Guang Liu, Dileep K. Vijayan, Ramadevi Subramani, Rajkumar Lakshmanaswamy, Suryavathi Viswanadhapalli, Gangadhara R. Sareddy, Surinder K. Batra, Ratna K. Vadlamudi

Journal Articles: Biochemistry & Molecular Biology

Midkine (MDK) is an oncofetal, heparin-binding cytokine that is re-expressed across diverse cancers and correlates with aggressive disease and treatment resistance. This review synthesizes current evidence on MDK as a coordinator of tumor-intrinsic signaling and microenvironmental remodeling. We summarize MDK structural features, extracellular matrix interactions, and receptor systems that mediate MDK signaling, highlighting LRP1 and PTPRZ1 with context-dependent participation of ALK, nucleolin and integrins. Downstream, MDK engages MAPK, PI3K-AKT, STAT3 and NF-κB pathways to promote tumor cell survival, epithelial-mesenchymal plasticity, and therapeutic stress tolerance. We then focus on tumor microenvironment (TME) programs shaped by MDK, including angiogenesis, fibroblast activation and …

Mucin 5ac Modulates Cancer-Associated Fibroblast Heterogeneity Through Epigenetic Reprogramming Of Precursor Cells, Rachel J. Kehrberg, Namita Bhyravbhatla, Zahraa Wajih Alsafwani, Xiaoqi Li, Gopalakrishnan Natarajan, Imran Khan, Randall E. Brand, Maneesh Jain, Surinder K. Batra, Sushil Kumar

Journal Articles: Biochemistry & Molecular Biology

Pancreatic cancer (PC) is characterized by extensive desmoplasia, with heterogeneous cancer-associated fibroblasts (CAFs) as a major component. However, the contribution of distinct precursor cells to CAF heterogeneity remains poorly defined. This study investigated the role of Muc5ac in modulating CAF heterogeneity by maturing precursor cells, including adipose-derived mesenchymal stem cells (AD-MSCs), bone marrow-derived MSCs (BM-MSCs), and pancreatic stellate cells (PSCs), into different CAF subsets. RNA sequencing of precursor cells treated with conditioned media from Muc5ac-proficient or -deficient cancer cells revealed distinct transcriptional profiles. Muc5ac significantly modulated the expression of Dnmts and Tets in AD-MSCs, promoting the acquisition of extracellular matrix …

Anchoring Roots And Spreading Branches: The Growth And Regulation Of Art Therapy In Singapore, Christine Phang

Art Therapy | Doctoral Dissertations

The development of art therapy in Singapore has advanced rapidly over the last two decades. Yet, to date, there has not been a comprehensive overview of art therapy in Singapore. Additionally, more research is needed to understand how the complex component of regulation can benefit the profession of art therapy. This study therefore set out to paint a picture of art therapy in Singapore, capture the art therapy community’s thoughts and opinions concerning regulation, and identify actionable ways to advance the profession. A mixed method design was employed which utilized a survey and interviews to gather quantitative, qualitative, and arts-informed …

Catching The Forgotten: Repairing The Safety Net For Cofa Migrants In The United States, Brian Aguilar

Lewis & Clark Law Review

Citizens of the Freely Associated States—the Republic of the Marshall Islands, the Federated States of Micronesia, and the Republic of Belau—are permitted to live and work in the United States without a visa under the Compacts of Free Association (COFA). Yet, for nearly three decades, COFA migrants were excluded from the federal public benefits safety net. This exclusion, a product of legislative oversight in the Personal Responsibility and Work Opportunity Reconciliation Act of 1996, devastated communities like the Marshallese in Springdale, Arkansas, who endured dangerous working conditions, poverty, and severe health vulnerabilities without access to critical federal benefits programs. While …

Law And The Moral Geography Of Urban Education, Rebecca Horwitz-Willis

Lewis & Clark Law Review

In contemporary discussions, urban schools are often labeled as “bad,” while suburban schools are generally regarded as “good.” These assessments are typically based on achievement metrics, resource allocations, and the demographics of student populations. However, this Article offers a new lens through which to analyze the valuation of urban schools: the relationship between local vice regulation and what I term “educational geographies” in urban areas. Specifically, it argues that the location of vice institutions in cities has disproportionately impacted Black neighborhoods, thereby devaluing the educational geographies within these communities. These distributions do not just impact market value, but rather, also …

A Chronic Pain Self-Management Quality Improvement Bundle For Veterans, Srijana D. Baniya

Doctor of Nursing Practice (DNP) Scholarly Projects

Introduction: Veterans often face challenges accessing care services due to limited awareness of available resources for support, Self-care, and mental health (Harding et al., 2019; Patel et al., 2024). Given the high prevalence of Chronic pain and opioid use in this population, Self-management (SM) education and non-pharmacologic interventions are required to address the biological, psychological, and social effects of pain (Bair et al., 2015; Mumba et al., 2024; Nahin, 2017; Higgins et al., 2020). This Quality improvement project aims to determine whether implementing an evidence-based SM bundle for chronic pain improved Pain severity scores and increased understanding of SM strategies. …

Serum Biomarker Trajectory Clusters Predict Functional Outcome And Quality Of Life For Traumatic Brain Injury, Thanh Son Do, Chantal Carnes, Zhihui Yang, Firas Kobeissy, Hamad Yadikar, Gayla R. Olbricht, Olli Tenovuo, Jussi P. Posti, Ewout W. Steyerberg, Lindsay Wilson, Nicole Von Steinbüchel, Endre Czeiter, Andras Buki, David K. Menon

Mathematics and Statistics Faculty Research & Creative Works

Serum brain-enriched biomarkers are increasingly employed in the clinical evaluation of traumatic brain injury (TBI) to assist with triage, neuroimaging decisions, and prognostication. However, the potential of temporal biomarker trajectories to inform disease monitoring and long-term outcomes remains underexplored. We aim to identify distinct biomarker trajectory (TRAJ) profiles in traumatic brain injury patients and to examine their associations with long-term clinical outcomes. The study included 373, CT-positive Intensive Care Unit (ICU) traumatic brain injury patients (256 with initial Glasgow Coma Scale 3–12) from the Collaborative European Neurotrauma Effectiveness Research in TBI (CENTER-TBI) core study who had at least two serum …

Evolution Of A Novel Neuronal Sex-Specifically Spliced Gene In Mosquitoes, Yael Norohasimbola Tsitohay

Student Theses and Dissertations

Female mosquitoes from many species require a blood meal from an animal host as a protein source for egg development and successful reproduction. The majority of mosquito species are generalists in their host preference, feeding on a range of animals including mammals, birds, and amphibians. However, a small fraction of mosquito species have evolved a preference for human hosts. These species are mainly found in the genera Aedes, Culex, and Anopheles, and they have created a global health crisis due to their ability to transmit deadly human pathogens including dengue virus, Zika virus, West Nile Virus, and …

Reproductive Success Is Secured By A Rapidly-Evolving Short Peptide In Female Aedes Aegypti Mosquitoes, Priyanka Lakhiani

Student Theses and Dissertations

The mosquito lineage spans hundreds of millions of years of evolution, and this period has honed the yellow fever mosquito, Aedes aegypti, into a precise and expert predator. While nectar and plant-derived carbohydrates are sufficient sources of nutrition to maintain energy and metabolism, female mosquitoes must acquire multiple ingredients to successfully reproduce and produce offspring. Healthy, motile sperm from a conspecific male and a complete blood meal from a human host are required for females to develop viable eggs, and thus ensure species survival. What are the internal mechanisms that coordinate the acquisition of these key elements with the maturation, …

Ancient Immune Systems: Sensing And Signaling In Bacterial-Phage Conflict, Cameron Grace Roberts

Student Theses and Dissertations

Viruses are among the most significant selective pressures shaping the evolution of life on Earth. In the microbial world, bacteriophages (phage) are bacterial viruses and drive a continuous evolutionary arms race that has led to an extraordinary diversity of bacterial defense mechanisms [1]. These systems are thought to have provided the evolutionary foundation for numerous eukaryotic immune strategies [2]. Experimental studies have validated many of these anti-phage defense systems and revealed the mechanisms by which they disrupt phage infection [3]. Nonetheless, major gaps persist in our understanding of how bacterial immune systems recognize bacteriophage infection to trigger immunity. This dissertation …

The Influence Of Dna Methylation On Both H2a.Z Nucleosome Dynamics And The Zinc Finger And Homeoboxes Transcription Factor Family, Rochelle M. Shih

Student Theses and Dissertations

DNA methylation represents a widespread and heritable modification that exerts substantial influence on chromatin organization and function in many eukaryotic genomes. The presence of DNA methylation has been strongly linked to transcriptional regulation, in both activating as well as repressive ways, though exactly how a small chemical mark can enact such drastic and seemingly opposing effects on gene expression remains an open question. In my thesis work, I describe the influence DNA methylation has on two classes of chromatin proteins, the histone variant H2A.Z and the Zinc Finger and Homeoboxes (ZHX) family of transcription factors. DNA methylation and H2A.Z preferentially …

The Reinnervation Of Sensory Hair Cells Following Lesion Of The Lateral Line Cranial Nerve, Rohan S. Roy

Student Theses and Dissertations

Loss of hearing is a prevalent sensory pathology in the United States and worldwide. A significant proportion of deafness is attributed to sensorineural hearing loss, which often involves damage and retraction of the nerve fibers that relay auditory information between the mechanosensitive hair cells of the inner ear and the brain. The restoration of physiologic hearing would require the regeneration of nerve fibers back into the sensory epithelium of the cochlea, followed by the reinnervation of appropriate hair cell targets. Nerve regeneration studies in humans and other mammalian models are lacking due to the limited accessibility of the inner ear. …

Structural And Functional Studies Of The Sars-Cov-2 Niran Domain, Gabriel I. Small

Student Theses and Dissertations

The COVID-19 pandemic was a dramatically disruptive event, wreaking devastation across the globe and radically impacting nearly every facet of human life. For the first time, a significant amount of global money and attention was directed at coronavirus (CoV) research, propelling the field to the forefront of biomedical research. This allowed for the rapid development of a suite of vaccines and antivirals targeting SARS-CoV-2 that aided in ameliorating the effects of the pandemic. SARS-CoV-2 was the third CoV zoonosis of the 21st century and is now endemic. Global understanding of the threats posed by CoVs circulating among animals in the …

Dining In The Dark Atp Sensing In The Female Aedes Aegypti Mosquito, Katherine Adriana Rosas Villegas

Student Theses and Dissertations

Blood feeding is fundamental for female Aedes aegypti mosquitoes, which require this protein-rich meal for egg development. After being attracted to a human host by sensory cues such as body odor, body heat, and carbon dioxide exhaled in human breath, the mosquito lands and probes under the skin to feed on blood. Probing uses the stylet, a sharp appendage ensheathed in the mosquito labium that punctures the skin and is highly specialized for blood ingestion. Previous work from the lab with GCaMP calcium imaging of stylet neurons showed that approximately 50% of stylet neurons respond to blood, and that these …

Academic Affairs Records, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

Prior to 1960, the administration of academic programs at South Dakota State College was managed independently by departments and offices. As administrative responsibilities expanded, the position of Dean of Academic Affairs was established in 1960 to centralize oversight, later becoming the Vice President for Academic Affairs in 1973. This role, reporting directly to the university president, oversees college deans and plays a key role in curriculum development, faculty governance, accreditation, and institutional planning. The office has been instrumental in shaping academic policies, managing faculty development, and ensuring compliance with higher education standards.

The Academic Affairs Records Collection (1902–2018) documents the …

Larsen, Ronald, Papers, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

Ronald “Ron” Larsen (1946–2019) was a South Dakota resident, educator, agricultural advocate, and political candidate. A graduate of South Dakota State University, Larsen was active in civic and agricultural issues during the 1980s and later became the Democratic nominee for the South Dakota State Senate in District 6 in 2004.

This collection documents Larsen’s public activities from 1983 to 2004. Materials include correspondence, donation letters, newspaper clippings, legislative and campaign records, proclamations, and campaign ephemera. A significant portion relates to the “Give-A-Buck” initiative (1983–1991), as well as agricultural advocacy efforts such as “Faith in Farming” and participation in the 1985 …

South Dakota Resources Coalition Records, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

The South Dakota Resources Coalition was established in the early 1970s amid expanding federal environmental regulation and growing grassroots activism. In 1972, Governor Richard Kneip encouraged coordination among citizen environmental groups, and Esther R. Edie helped connect organizations statewide. This effort culminated in a South Dakota Environmental Symposium on September 28, 1972, which brought together state officials, specialists, and community representatives to address issues including water management, forestry practices, air quality, recycling, and the creation of a formal statewide organization. The South Dakota Environmental Coalition emerged from this meeting and soon engaged in state and national issues such as the …

Reifel Papers, Ben, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

The Ben Reifel Papers document the professional and public life of Ben Reifel, the first Lakota Sioux elected to the United States Congress, with particular emphasis on his service in federal Indian affairs, his congressional career, and his continued public service after leaving elected office. The collection includes correspondence, photographs, audiovisual recordings, memorabilia, scrapbooks, speeches, and writings that trace his work with the Bureau of Indian Affairs, his legislative activities in the U.S. House of Representatives, and his involvement with national, state, and tribal organizations. Materials also reflect his military service, educational background, campaign activities, and long-standing engagement with civic …

Cook-Lynn Papers, Elizabeth, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

The Elizabeth Cook-Lynn Papers document the life, career, and scholarship of Dakota author, editor, and educator Elizabeth Cook-Lynn (1930–2023), an enrolled member of the Crow Creek Sioux Tribe. Born in Fort Thompson, South Dakota, on the Crow Creek Indian Reservation, Cook-Lynn earned a B.A. in English and Journalism from South Dakota State College in 1952 and later completed an M.Ed. in Psychology and Counseling at the University of South Dakota. After beginning her career as a secondary school teacher, she joined the faculty of Eastern Washington University, where she taught English and Native American Studies from 1971 to 1990. During …

Protected And Conserved Areas In Canada: Advancing Conservation Policy, Practice & Indigenous Leadership, Christopher J. Lemieux, Don Carruthers Den Hoed, Eli Enns, Catherine E. Reining

Geography and Environmental Studies Faculty Publications

Protected and Conserved Areas in Canada: Advancing Conservation Policy, Practice, and Indigenous Leadership, is Canada’s first bilingual, interdisciplinary, open-access textbook dedicated to the evolving management and planning of protected and conserved areas. This resource addresses critical pressures and transitions in conservation, integrating Indigenous perspectives and case studies from across Canada to prepare the next generation of practitioners and researchers to become ethical, equitable, and effective decision-makers.

Over the past decade, Canada has experienced rapid expansion of protected and conserved areas, including the rise of Indigenous Protected and Conserved Areas (IPCAs), the expansion of marine protected and conserved areas, and …

Aires Protégées Et Conservées Au Canada: Faire Progresser Les Politiques, Les Pratiques, Et Le Leadership Autochtone En Matière De Conservation, Christopher J. Lemieux, Don Carruthers Den Hoed, Eli Enns, Catherine E. Reining

Geography and Environmental Studies Faculty Publications

Aires protégées et conservées au Canada : faire progresser les politiques, les pratiques et le leadership autochtone en matière de conservation est le premier manuel bilingue, interdisciplinaire et en libre accès au Canada consacré à la gestion et à la planification en pleine évolution des aires protégées et conservées. Cette ressource aborde les enjeux et transitions critiques qui marquent le domaine de la conservation, en intégrant les perspectives autochtones et des études de cas provenant de tout le pays, pour préparer la prochaine génération de praticiens et de chercheurs à devenir des décideurs éthiques, équitables et efficaces.

Au cours de …

Confronting Inequality: Three Eras Of Gender And Tax Scholarship, Bridget J. Crawford

Elisabeth Haub School of Law Faculty Publications

Tax law is not neutral--it encodes social values and reinforces certain longstanding hierarchies. For over fifty years, legal scholarship at the intersection of gender and tax has exposed how seemingly neutral tax laws perpetuate gender inequality. This Article uses the metaphor of quilting to trace the evolution of this scholarly field across three distinct eras.   Part I names and defines the designing era (1971-1986), which began with Grace Blumberg's writing on the gendered impact of tax laws on marriage, labor, and caregiving; she framed taxation as a tool of social control over women. Blumberg's work laid the foundation for other …

The Sleep, Inhibition, And Performance (Sip) Study: An Erp Investigation Of Sleep, Stress, And Response Inhibition In Early Childhood, Alivia Overbee

Master's Theses and Doctoral Dissertations

Background: Inhibitory control (IC) is fundamental to academic achievement and mental health, yet limited research examines how modifiable environmental factors influence neural substrates of IC in early childhood. Sleep regulation and adversity may shape IC development through experiential canalization processes. Objective: The Sleep, Inhibition, and Performance (SIP) study investigates how sleep characteristics, socioeconomic status (SES), and stress predict neural markers of inhibitory control in children aged 5-8 using event-related potentials (ERPs). Methods: Twenty children were enrolled in this study, which assessed sleep assessment via actigraphy, sleep diaries, and questionnaires. SES and stress were measured through caregiver reports. IC was assessed …