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Articles 13981 - 14010 of 18657
Full-Text Articles in Entire DC Network
Politics, An Illusion We Have Forgotten Is Such, Bradley Kaye
Politics, An Illusion We Have Forgotten Is Such, Bradley Kaye
Fast Capitalism
No abstract provided.
The Cracks In The Walls: Earthquakes, Patriarchy, And Transnational Capital In Haitian Free Trade Zones, Joshua E. Olsberg
The Cracks In The Walls: Earthquakes, Patriarchy, And Transnational Capital In Haitian Free Trade Zones, Joshua E. Olsberg
Fast Capitalism
No abstract provided.
Characteristics Of One Escherichia Coli Strain Isolated From The Sick Red Panda Excreting Mucus-Like Faeces, Dongjie Cai, Lanjing Ma, Xingxin Fu, Bin Tian, David Ranucci
Characteristics Of One Escherichia Coli Strain Isolated From The Sick Red Panda Excreting Mucus-Like Faeces, Dongjie Cai, Lanjing Ma, Xingxin Fu, Bin Tian, David Ranucci
The Thai Journal of Veterinary Medicine
The purpose of this study is to explore the main pathogens that caused one red panda to excrete mucus-containing faeces continuously. The anal swabs of sick red panda were collected for bacterial isolation, biochemical analysis, 16SrRNA sequencing identification, antimicrobial susceptibility testing, and research on pathogenicity in Mice. An Escherichia coli (E. coli) strain was isolated and determined. This strain was resistant to ampicillin, penicillin G, ceftiofur, and highly sensitive to levofloxacin, imipenem, azithromycin, kanamycin, and compound sulfamethoxazole. All mice died within 8-14 hours after injected intraperitoneally with 6×108 CFU/mL E. coli. Histopathology showed that the lungs, …
Understanding Gender Differences In Academic Achievement Among Engineering Students, Luai Al Labadi, Mohammad Saleh Bataineh, Lim Kyuson, Nida Siddiqui
Understanding Gender Differences In Academic Achievement Among Engineering Students, Luai Al Labadi, Mohammad Saleh Bataineh, Lim Kyuson, Nida Siddiqui
International Journal for Research in Education
In recent years, a noticeable shift has occurred in academic performance, with females consistently outperforming males in mathematical engineering courses. To investigate the factors contributing to this trend, we conducted a comprehensive survey at a main university in UAE. Analyzing data from 431 engineering students, we found that the time spent studying outside the classroom plays a pivotal role, evidenced by a statistically significant p-value of 0.04, contributing to the gender-based performance disparity. Building upon these findings, we propose short-term solutions that instructors and universities can implement promptly to address this issue. This study underscores the importance of ongoing institution-level, …
Concurrent And Longitudinal Predictions Of Math Anxiety, Science Anxiety, And Enrollment In Science And Art Tracks In Secondary Education, Ahmed Megreya, Ahmed Al-Emadi
Concurrent And Longitudinal Predictions Of Math Anxiety, Science Anxiety, And Enrollment In Science And Art Tracks In Secondary Education, Ahmed Megreya, Ahmed Al-Emadi
International Journal for Research in Education
The worldwide need for STEM (Science, Technology, Engineering, and Mathematics) expertise highlights the critical importance of examining education-related emotions that shape students’ educational pathways and career decisions. Using a sample of tenth-grade students from Qatari schools (N = 391) and a follow-up sample in eleventh grade (N = 350), after their enrollment in either the art or science track, the present study examined the concurrent and longitudinal predictions of math anxiety, science anxiety, and track enrollments in secondary education. The science track attracted a larger number of male students, whereas the art track drew a higher proportion of female students. …
How Does General Anesthesia Affect The Developing Brain Compared To The Adult, Yaroslav Sokolovskyi
How Does General Anesthesia Affect The Developing Brain Compared To The Adult, Yaroslav Sokolovskyi
Mentorship Program 2025-2026
No abstract provided.
Patient-Specific Lumped-Parameter Model For Quantifying Vessel-Specific Remodeling And Predicting Right Ventricular Function In Pulmonary Hypertension, Christopher G. Lechuga, Amirreza Kachabi, Mitchel J. Colebank, Claudia E. Korcarz, Farhan Raza
Patient-Specific Lumped-Parameter Model For Quantifying Vessel-Specific Remodeling And Predicting Right Ventricular Function In Pulmonary Hypertension, Christopher G. Lechuga, Amirreza Kachabi, Mitchel J. Colebank, Claudia E. Korcarz, Farhan Raza
Faculty Publications
Purpose: Pulmonary hypertension (PH) is a heterogeneous disease with patient-specific variability and vessel-specific remodeling, which eventually lead to right ventricular (RV) failure. The gold standard for RV assessment—pressure–volume (PV) loop acquisition—is invasive and limited to specialized settings. This study aims to develop a patient-specific lumped-parameter model that quantifies vessel-specific remodeling and simulates RV PV loops across PH phenotypes using routine clinical data.
Methods: A lumped-parameter model was calibrated using right heart catheterization and echocardiography data. Model agreement was assessed by R2 values for pressure and flow goodness-of-fit, and model-derived hemodynamic metrics were comparedwith clinical values. A dimensionality reduction approach was …
The Student Movement Volume 110 Issue 11: A Snowy Start To Spring Semester, Corinna Bevier, Audrey Lim, Addison Randall, Jj Nixon, Megan Constantine, Joey Carrion, Isa Demoraes, Caleb Chung, Aiko J. Ayala Rios, Reagan Westerman, Joseph Piresson Ii, Anna Rybachek, Maya Thomas
The Student Movement Volume 110 Issue 11: A Snowy Start To Spring Semester, Corinna Bevier, Audrey Lim, Addison Randall, Jj Nixon, Megan Constantine, Joey Carrion, Isa Demoraes, Caleb Chung, Aiko J. Ayala Rios, Reagan Westerman, Joseph Piresson Ii, Anna Rybachek, Maya Thomas
The Student Movement V. 110 (2025-2026)
ARTS & ENTERTAINMENT
In the Doghouse: Canine Awarded for Acting Performance, Corinna Bevier
On the Trump-Kennedy Center, Audrey Lim
Students Step Up as Wind Symphony Keeps Winter Concert Alive, Addison Randall
HUMANS
Senior Spotlight: Derek Wonenberg, JJ Nixon
Lessons From 2025, Goals For 2026, Megan Constantine
NEWS
Spring Convocation Offers Spiritual Exhortation and Academic Celebration, Joey Carrion
Andrews University Experiences GYC, Isa DeMoraes
IDEAS
Finding Balance between Grind and Chill, Caleb Chung
The Price of Being an International Student (and How to Address It), Aiko J. Ayala Rios
The Internet: Tool or Foe?, Reagan Westerman
Op-Ed: A Letter for Better …
Characterization Of Ru(Ii) Polypyridyl Photosensitizers Bound To Tio2 Supports Through A New Covalent Metal-Ester Bonding Motif, D. M. S. C. Dissanayake, Christopher T. Lebarron, Laura C. Maybach, Joseph J. Kuchta Iii, Seyyedamirhossein Hosseini, Aaron K. Vannucci
Characterization Of Ru(Ii) Polypyridyl Photosensitizers Bound To Tio2 Supports Through A New Covalent Metal-Ester Bonding Motif, D. M. S. C. Dissanayake, Christopher T. Lebarron, Laura C. Maybach, Joseph J. Kuchta Iii, Seyyedamirhossein Hosseini, Aaron K. Vannucci
Faculty Publications
The development of photoelectrochemical (PEC) devices involves the attachment of molecular photosensitizers onto solid supports. Particularly significant to this work are PECs that rely on ruthenium-based photosensitizers on high band gap metal oxide (MOx) supports. In this study, we have explored a new ester binding motif (MOx-ester) to covalently attach a ruthenium polypyridyl photosensitizer to TiO2. This new MOx-ester photoanode is compared to the traditional photoanodes that utilize acid/base binding groups to attach the molecular Ru sensitizers to TiO2. The new MOx-ester binding motif is characterized by cyclic voltammetry UV-Vis, solid state 13C NMR, and …
Reframing The At-Risk Discourse: From Victim Blaming To Nurturing Resilience, Romana Mathews
Reframing The At-Risk Discourse: From Victim Blaming To Nurturing Resilience, Romana Mathews
Electronic Theses and Dissertations Archive
Each year, approximately 1.2 million students drop out of high school in the United States—about one every 26 seconds (National Center for Education Statistics, 2023). This trend calls for a reexamination of how we understand and support students labeled “at-risk.” Traditional deficit-based models focus narrowly on challenges, often overlooking how students actively build resilience to navigate adversity. This study explores how successful high school graduates from rural Title I schools in the southern United States interpret the “at-risk” label and develop resilience. Guided by two research questions (1) How do these graduates interpret and make meaning of the “at-risk” label? …
From Latent Manifolds To Targeted Molecular Probes: An Interpretable, Kinome-Scale Generative Machine Learning Framework For Family-Based Kinase Ligand Design, Gennady M. Verkhivker, Ryan Kassab, Keerthi Krishnan
From Latent Manifolds To Targeted Molecular Probes: An Interpretable, Kinome-Scale Generative Machine Learning Framework For Family-Based Kinase Ligand Design, Gennady M. Verkhivker, Ryan Kassab, Keerthi Krishnan
Mathematics, Physics, and Computer Science Faculty Articles and Research
Scaffold-aware artificial intelligence (AI) models enable systematic exploration of chemical space conditioned on protein-interacting ligands, yet the representational principles governing their behavior remain poorly understood. The computational representation of structurally complex kinase small molecules remains a formidable challenge due to the high conservation of ATP active site architecture across the kinome and the topological complexity of structural scaffolds in current generative AI frameworks. In this study, we present a diagnostic, modular and chemistry-first generative framework for design of targeted SRC kinase ligands by integrating ChemVAE-based latent space modeling, a chemically interpretable structural similarity metric (Kinase Likelihood Score), Bayesian optimization, and …
Transforming Reproductive Health Through Education: A Menstrual Health Literacy And Empowerment Questionnaire To Support Psychological Well-Being, Francesca Dellamaggiore
Transforming Reproductive Health Through Education: A Menstrual Health Literacy And Empowerment Questionnaire To Support Psychological Well-Being, Francesca Dellamaggiore
Doctor of Psychology (PsyD)
Menstrual health remains an underexamined area within psychological and reproductive health research despite its relevance to emotional functioning, self-advocacy, health literacy, and overall well-being. Limited education about the menstrual cycle, combined with persistent stigma and misinformation, may leave many individuals unprepared to understand their bodies and communicate effectively with healthcare providers. The present study aimed to develop and provide a preliminary psychometric evaluation of the Menstrual Health Literacy and Empowerment (MHLE) Questionnaire, a novel measure designed to assess menstrual cycle knowledge, menstrual attitudes, and empowerment-related processes associated with psychological well-being. Participants were recruited through community and university-based sampling methods and …
Iron-Involved Orr Electrocatalysts Under The Lens Of In-Situ/Operando Mössbauer Spectroscopy, Sumbal Farid, Jun-Hu Wang
Iron-Involved Orr Electrocatalysts Under The Lens Of In-Situ/Operando Mössbauer Spectroscopy, Sumbal Farid, Jun-Hu Wang
Journal of Electrochemistry
Exploring cost-effective and efficient catalysts for oxygen reduction reaction (ORR) poses a significant challenge, especially in the pursuit of alternatives to precious metals like platinum. Significant advancements have driven electrochemists to develop efficient ORR catalysts using abundant materials, particularly iron (Fe)-based, known for their exceptional performance in ORR. While the crucial function of Fe in boosting ORR catalytic activity is recognized, the connection between material attributes and catalytic performance remains enigmatic. Understanding the dynamic processes involved in oxygen electrocatalysis is paramount for designing precious-metals-free ORR electrocatalysts. Mössbauer spectroscopy stands out as a powerful technique for deciphering the structural characteristics of …
The Effects Of Ovine-Derived Reinforced Tissue Matrix Surrounding Silicone-Based Implants In A Rat Prepectoral Reconstruction Model, Sai L Pinni, Cameron Martin, Nicholas Fadell, Xiaochao Xia, Evan Marsh, Lauren Schellhardt, Xiaowei Li, Matthew D Wood, Justin M Sacks
The Effects Of Ovine-Derived Reinforced Tissue Matrix Surrounding Silicone-Based Implants In A Rat Prepectoral Reconstruction Model, Sai L Pinni, Cameron Martin, Nicholas Fadell, Xiaochao Xia, Evan Marsh, Lauren Schellhardt, Xiaowei Li, Matthew D Wood, Justin M Sacks
2020-Current year OA Pubs
Silicone-based implants have been widely used in breast reconstruction but have also been associated with poorly understood complications, including pathologic foreign body responses such as capsular contracture. In this study, we leveraged 3D-printing technology to generate silicone-based implants in a novel, anatomically relevant, prepectoral rat model. We used this model to evaluate the response to an extracellular matrix-based product: ovine-derived reinforced tissue matrix (RTM). Two-piece negative molds were developed through computer-aided design and 3D-printed. The molds were filled with various polydimethylsiloxane mixtures and dip-coated to fabricate implants. Implant material characterization revealed that the implants retained the original 3D-printed mold shape …
Mast Cells Promote Pathology And Susceptibility In Tuberculosis, Ananya Gupta, Vibha Taneja, Javier Rangel-Moreno, Nilofer Naqvi, Abhimanyu, Yun Tao, Mushtaq Ahmed, Kuldeep Singh Chauhan, Daniela Trejo-Ponce De Leon, Gustavo Ramírez-Martínez, Luis Jiménez-Alvarez, Cesar Luna-Rivero, Joaquin Zuniga, Deepak Kaushal, Shabaana A Khader
Mast Cells Promote Pathology And Susceptibility In Tuberculosis, Ananya Gupta, Vibha Taneja, Javier Rangel-Moreno, Nilofer Naqvi, Abhimanyu, Yun Tao, Mushtaq Ahmed, Kuldeep Singh Chauhan, Daniela Trejo-Ponce De Leon, Gustavo Ramírez-Martínez, Luis Jiménez-Alvarez, Cesar Luna-Rivero, Joaquin Zuniga, Deepak Kaushal, Shabaana A Khader
2020-Current year OA Pubs
Tuberculosis (TB), caused by the bacterium
Can A Fish Serve As An Environmental Bellwether?, Mark Wanner
Can A Fish Serve As An Environmental Bellwether?, Mark Wanner
UNH Today Archive
No abstract provided.
Community Synchrony In Aquatic Macroinvertebrates Is Unrelated To Environmental Variability But Differs Among Functional Feeding Groups, Anthony J. Pignatelli, Tad Dallas
Community Synchrony In Aquatic Macroinvertebrates Is Unrelated To Environmental Variability But Differs Among Functional Feeding Groups, Anthony J. Pignatelli, Tad Dallas
Faculty Publications
Environments are becoming increasingly more variable, as a function of climate change. As this occurs, species may be exposed to conditions outside their preferred range. Such variability in the environment can influence community abundance as individual species respond either similarly (synchronous dynamics) or differently (asynchronous dynamics) to each other. These fluctuations in abundances are important for understanding the impact of environmental variability on species temporal fluctuations in aquatic macroinvertebrates. This group of organisms is species-rich and highly sensitive to environmental fluctuations. We analyzed 18 stream macroinvertebrate communities sampled by the National Ecological Observatory Network between 2014 and2022 to understand how …
Defining The Heterogeneous Molecular Landscape Of Lung Cancer Cell Responses To Epigenetic Inhibition, Chuwei Lin, Catherine M Sniezek, Christopher D Mcgann, Rashmi Karki, Ross M Giglio, Benjamin A Garcia, José L Mcfaline-Figueroa, Devin K Schweppe
Defining The Heterogeneous Molecular Landscape Of Lung Cancer Cell Responses To Epigenetic Inhibition, Chuwei Lin, Catherine M Sniezek, Christopher D Mcgann, Rashmi Karki, Ross M Giglio, Benjamin A Garcia, José L Mcfaline-Figueroa, Devin K Schweppe
2020-Current year OA Pubs
Epigenetic inhibitors exhibit powerful antiproliferative and anticancer activities. However, cellular responses to small-molecule epigenetic inhibition are heterogeneous and dependent on factors such as the genetic background and metabolic state of cells, as well as on-/off-target engagement of individual small-molecule compounds. The molecular study of the extent of this heterogeneity often measures changes in a single cell line. To more comprehensively profile the effects of small-molecule perturbations and their influence on heterogeneous cellular responses, we present a molecular resource based on the quantification of chromatin, proteome, and transcriptome remodeling due to histone deacetylase inhibitors (HDACi) in non-isogenic cell lines. Through quantitative …
Identification Of Slc3a2 As A Potential Therapeutic Target Of Ferroptosis In Bladder Cancer, Qi Yang, Dewang Zhou, Aaron Beasley, Yujun Liu, Zeqin Yan, Hu Fang, Yuqing Li, Elin S. Gray
Identification Of Slc3a2 As A Potential Therapeutic Target Of Ferroptosis In Bladder Cancer, Qi Yang, Dewang Zhou, Aaron Beasley, Yujun Liu, Zeqin Yan, Hu Fang, Yuqing Li, Elin S. Gray
Research outputs 2022 to 2026
Bladder cancer (BC) represents the most prevalent malignancy within the urinary system. Mounting evidence underscores the critical involvement of ferroptosis in cancer pathogenesis; Consequently, this study delves into its molecular underpinnings and therapeutic potential specifically in BC. Methods: We analyzed gene expression profiles from The Cancer Genome Atlas (TCGA) and the Gene Expression Om-nibus (GEO) repositories. Ferroptosis-related genes (FRGs) were selected from the FerrDb database. Utilizing systematic bioinformatics analyses, we identify differentially expressed and prognostic FRGs and construct an FRGs prognostic model. Combined with protein-protein interaction (PPI) analysis, solute carrier family 3 member 2 (SLC3A2) was selected for further study. …
Drought × Herbivory Induce Leaf Trichomes In Soybean With Differential Impact On Its Major Herbivore Soybean Looper Chrysodeixis Includens, Manish Gautam, Karen Alanis, Rupesh R. Kariyat
Drought × Herbivory Induce Leaf Trichomes In Soybean With Differential Impact On Its Major Herbivore Soybean Looper Chrysodeixis Includens, Manish Gautam, Karen Alanis, Rupesh R. Kariyat
School of Integrative Biological & Chemical Sciences Faculty Publications
Trichomes have been well studied as a physical defense against stress. With climate change, stressors like drought and/or herbivory can have exacerbated effects on crop morpho-physiology. However, the interactive effects of such stressors on physical defenses like trichomes and their effects on herbivores is poorly understood. To examine this, soybean plants were exposed to a major herbivore, soybean looper (SBL) (Chrysodeixis includens Walker), under simulated drought conditions to examine the interactive effects of drought and herbivory (D × H) on leaf trichomes. Additionally, SBL growth traits were monitored under different leaf diet concentrations (10% and 20%) and trichome enriched diets …
Editorial: Next-Generation Protacs In Oncology And Beyond: Exploring Therapeutic Targets And Their Degraders, Daiqing Liao, Debasish Bandyopadhyay
Editorial: Next-Generation Protacs In Oncology And Beyond: Exploring Therapeutic Targets And Their Degraders, Daiqing Liao, Debasish Bandyopadhyay
School of Integrative Biological & Chemical Sciences Faculty Publications
No abstract provided.
A Comparison Of The Effectiveness Of Salmonella-Shigella (Ss) Agar And Xylose Lysine Deoxycholate (Xld) Agar In Supporting The Growth Of Salmonella Sp. And Shigella Sp., Ika Ningsih, Kharisma Winnie Chryssantium Tiro
A Comparison Of The Effectiveness Of Salmonella-Shigella (Ss) Agar And Xylose Lysine Deoxycholate (Xld) Agar In Supporting The Growth Of Salmonella Sp. And Shigella Sp., Ika Ningsih, Kharisma Winnie Chryssantium Tiro
Indonesian Journal of Medical Chemistry and Bioinformatics
Diarrheal diseases caused by Salmonella sp. and Shigella sp. are among the most significant public health challenges worldwide, especially among children. To identify these bacteria, Salmonella-Shigella (SS) and Xylose Lysine Deoxycholate (XLD) agar media are used, which are selective and differential for Salmonella sp. and Shigella sp. Although these media share similar properties and functions for growing Salmonella sp. and Shigella sp., results from previous studies differ from those obtained in tests conducted by the Department of Microbiology, Faculty of Medicine, University of Indonesia. This laboratory-based experimental study used serial dilution with three replicates (triplicate). Based on SNI 2897 of …
What's New With Journal Subscriptions And Open Access Fee Waivers (2026), Rebecca Bealer Mlis, Lsu Health Libraries
What's New With Journal Subscriptions And Open Access Fee Waivers (2026), Rebecca Bealer Mlis, Lsu Health Libraries
Library Instruction
2026 brings a few changes to journals and fee waivers offered by the Library. We will cover journals added and cancelled, as well as continuing and new open access and fee waiver agreements. Recorded session from the information session that took place on January 28, 2026.
Kdm4a Promotes Nepc Progression Through Regulation Of Myc Expression, Celia Sze Ling Mak, Ming Zhu, Jie Fu, Xin Liang, Xiaoxuan Wang, Fei Yuan, Feng Wang, Anh G Hoang, Xingzhi Song, Peter Shepherd, Derek Liang, Jessica Suh, Jordan Contreras, Thisawin Dang, Cindy Yan, Brandon Figueroa, Mathias Mazzocco, Athena Luo, Bijeta Pradhan, Jiwon Park, Mirrah Bashir, Miao Zhang, Eric Metzger, Roland Schüle, Abhinav K Jain, Ellen Karasik, Daniel Frigo, Barbara A Foster, Min Gyu Lee, Paul Corn, Christopher J Logothetis, Ana Aparicio, Nora Navone, Patricia Troncoso, Zhi Tan, Jianhua Zhang, Sue-Hwa Lin, Guocan Wang
Kdm4a Promotes Nepc Progression Through Regulation Of Myc Expression, Celia Sze Ling Mak, Ming Zhu, Jie Fu, Xin Liang, Xiaoxuan Wang, Fei Yuan, Feng Wang, Anh G Hoang, Xingzhi Song, Peter Shepherd, Derek Liang, Jessica Suh, Jordan Contreras, Thisawin Dang, Cindy Yan, Brandon Figueroa, Mathias Mazzocco, Athena Luo, Bijeta Pradhan, Jiwon Park, Mirrah Bashir, Miao Zhang, Eric Metzger, Roland Schüle, Abhinav K Jain, Ellen Karasik, Daniel Frigo, Barbara A Foster, Min Gyu Lee, Paul Corn, Christopher J Logothetis, Ana Aparicio, Nora Navone, Patricia Troncoso, Zhi Tan, Jianhua Zhang, Sue-Hwa Lin, Guocan Wang
Faculty, Staff and Students Publications
Neuroendocrine prostate cancer (NEPC) is a highly aggressive and lethal subtype of prostate cancer (PCa) that often emerges in response to androgen receptor pathway inhibitors (ARPIs), which are widely used in treating metastatic castration-resistant and hormone-sensitive prostate cancer. The incidence of NEPC is increasing, yet effective therapeutic strategies remain limited due to an incomplete understanding of its molecular drivers. Through transcriptomic analyses of human prostate tumor samples, we identified the histone lysine demethylase KDM4A as uniquely overexpressed in human and mouse NEPC compared to prostate adenocarcinoma. Functional validation demonstrated that KDM4A is a key regulator of NEPC progression and a …
Translating Cardiovascular Ion Channel And Ca2+ Signalling Mechanisms Into Therapeutic Insights, Silvia Marchianò, Miguel Martín-Aragón Baudel, Charlotte E R Smith, Gonzalo Hernandez Hernandez, Donald M Bers, Patrick M Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F Harraz, Na Li, Thomas A Longden, William E Louch, Madeline Nieves-Cintron, Matthew A Nystoriak, Walter Lee Murfee, Przemysław B Radwański, Swapnil K Sonkusare, Manuel F Navedo, Eleonora Grandi
Translating Cardiovascular Ion Channel And Ca2+ Signalling Mechanisms Into Therapeutic Insights, Silvia Marchianò, Miguel Martín-Aragón Baudel, Charlotte E R Smith, Gonzalo Hernandez Hernandez, Donald M Bers, Patrick M Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F Harraz, Na Li, Thomas A Longden, William E Louch, Madeline Nieves-Cintron, Matthew A Nystoriak, Walter Lee Murfee, Przemysław B Radwański, Swapnil K Sonkusare, Manuel F Navedo, Eleonora Grandi
Faculty, Staff and Students Publications
Cardiovascular diseases remain the leading cause of mortality worldwide, driven by complex, multi-scale mechanisms that span molecular, cellular, and organ-level dysfunction. Effective therapeutic strategies therefore require integrative approaches that link fundamental biology to translational applications. The 8th UC Davis CardioVascular Symposium gathered experts in ion channel biophysics, Ca2+ signaling, arrhythmia mechanisms, and cardiovascular physiology to discuss recent advances and define emerging priorities. This white paper synthesizes the key themes and consensus points that emerged, highlighting progress in two core domains: (1) advances in cardiovascular electrophysiology and arrhythmia mechanisms, and (2) spatiotemporal dynamics of Ca2+ signaling in cardiac and vascular function …
Crispr Screens In Ipsc-Derived Neurons Reveal Principles Of Tau Proteostasis, Avi J. Samelson, Nabeela Ariqat, Justin Mcketney, Gita Rohanitazangi, Celeste Parra Bravo, Rudra S. Bose, Kyle J. Travaglini, Victor L. Lam, Darrin Goodness, Thomas Ta, Gary Dixon, Emily Marzette, Julianne Jin, Ruilin Tian, Eric Tse, Romany Abskharon, Henry S. Pan, Emma C. Carroll, Rosalie E. Lawrence, For Full Author List, See Comments Below
Crispr Screens In Ipsc-Derived Neurons Reveal Principles Of Tau Proteostasis, Avi J. Samelson, Nabeela Ariqat, Justin Mcketney, Gita Rohanitazangi, Celeste Parra Bravo, Rudra S. Bose, Kyle J. Travaglini, Victor L. Lam, Darrin Goodness, Thomas Ta, Gary Dixon, Emily Marzette, Julianne Jin, Ruilin Tian, Eric Tse, Romany Abskharon, Henry S. Pan, Emma C. Carroll, Rosalie E. Lawrence, For Full Author List, See Comments Below
Faculty Research, Scholarly, and Creative Activity
Aggregation of the protein tau defines tauopathies, the most common age-related neurodegenerative diseases, which include Alzheimer’s disease and frontotemporal dementia. Specific neuronal subtypes are selectively vulnerable to tau aggregation, dysfunction, and death. However, molecular mechanisms underlying cell-type-selective vulnerability are unknown. To systematically uncover the cellular factors controlling the accumulation of tau aggregates in human neurons, we conducted a genome-wide CRISPRi screen in induced pluripotent stem cell (iPSC)-derived neurons. The screen uncovered both known and unexpected pathways, including UFMylation and GPI anchor biosynthesis, which control tau oligomer levels. We discovered that the E3 ubiquitin ligase CRL5SOCS4 controls tau levels in …
Wmd Transformations: When Did An Rpg Become A Wmd?, Binoy Kampmark
Wmd Transformations: When Did An Rpg Become A Wmd?, Binoy Kampmark
Fast Capitalism
No abstract provided.
The Role Of Marketing In The Infantilization Of The Postmodern Adult, Jacopo Bernardini
The Role Of Marketing In The Infantilization Of The Postmodern Adult, Jacopo Bernardini
Fast Capitalism
No abstract provided.
Mondialisation And Critiques Of Capitalism, Bregham Dalgliesh
Mondialisation And Critiques Of Capitalism, Bregham Dalgliesh
Fast Capitalism
No abstract provided.
The Spirit Of The Trail: Culture, Popularity And Prize Money In Ultramarathoning, Gary C. David
The Spirit Of The Trail: Culture, Popularity And Prize Money In Ultramarathoning, Gary C. David
Fast Capitalism
No abstract provided.