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Prediction Of Outcome From Spatial Protein Profiling Of Triple-Negative Breast Cancers., Ali Foroughi Pour, Te-Chia Wu, Javad Noorbakhsh, Jan Martinek, Santhosh Sivajothi, Paul Robson, Karolina Palucka, Jeffrey Chuang

Faculty Research 2026

BACKGROUND: In tumors, reciprocal spatial interactions between immune cells, their mediators, the extracellular matrix, and mutated neoplastic cells impact all aspects of treatment resistance. The operational mechanisms of these interactions are foundational for developing insights and targets for cancer therapy and prevention. Spatial quantification of the tumor microenvironment system from image data has untapped potential for patient stratification.

METHODS: Here, we present SparTile, a powerful computational approach for the analysis of multiplex proteomics images to reveal clinically relevant structural organization in the tumor microenvironment. SparTile enables robust and unbiased identification and characterization of tumor microenvironments based on spatial relationships among …

Prediction Of Outcome From Spatial Protein Profiling Of Triple-Negative Breast Cancers., Ali Foroughi Pour, Te-Chia Wu, Javad Noorbakhsh, Jan Martinek, Santhosh Sivajothi, Paul Robson, Karolina Palucka, Jeffrey Chuang

Faculty Research 2026

BACKGROUND: In tumors, reciprocal spatial interactions between immune cells, their mediators, the extracellular matrix, and mutated neoplastic cells impact all aspects of treatment resistance. The operational mechanisms of these interactions are foundational for developing insights and targets for cancer therapy and prevention. Spatial quantification of the tumor microenvironment system from image data has untapped potential for patient stratification.

METHODS: Here, we present SparTile, a powerful computational approach for the analysis of multiplex proteomics images to reveal clinically relevant structural organization in the tumor microenvironment. SparTile enables robust and unbiased identification and characterization of tumor microenvironments based on spatial relationships among …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Effects Of Hydro- And Nano-Priming Treatments On Seed Germination And Metabolism In Sugar Beet (Beta Vulgaris L.), Sarah Jorjani, Ömer Can Ünüvar, Songül Gürel, Ekrem Gürel

Turkish Journal of Botany

This study examined the effects of hydropriming and nanopriming on the germination and physiological parameters of sugar beet seeds. Seeds were treated with distilled water as a traditional method and with TiO2 nanoparticle solutions at concentrations of 5, 10, and 15 ppm as an advanced method. Seeds were soaked for 3, 6, and 9 h, followed by postpriming maintenance for 10 and 45 days. T he results indicated no statistically significant differences in germination rates between the control and primed groups. Both priming methods markedly increased alpha-amylase activity and chlorophyll content, indicating improved metabolic and photosynthetic potential. Notably, nanopriming for …

Modeling Global Ecological Niche Shifts Of Osyris Spp. Under Climate Change Scenarios: Conservation Priorities For A Threatened Genus, Meng Ting-Yao, Han Shun-Long, He Xiang-Tian, Wu Ya-Ni, Fengjuan Mou

Turkish Journal of Botany

The genus Osyris L. comprises ecologically and economically important evergreen shrubs or small trees, with particular African species currently threatened by unsustainable exploitation. This study projected potential ecological niche shifts for Osyris under four Shared Socioeconomic Pathways (SSPs) using digitized herbarium specimen localities and 20 environmental variables. The genus currently occupies a broad range between 41.32°N–34.85°S latitude and 9.27°W–109.03°E longitude, at elevations from 0 to 3900 m. High-suitability areas cluster primarily in the European-Mediterranean region, eastern/southern Africa, western South America, and Southeast Asia. Projections indicate a significant decline in high-suitability area under all SSP scenarios (SSP126, SSP245, SSP370, SSP585) compared …

Combined Glycoprotein Mutations In Rabies Virus Promote Astrocyte Tropism And Protective Cns Immunity In Mice, Mirjam Anna Rita Bertoune, Corinna Kolbe, Ann-Cathrin Werner, Maren Steinmetz, Bernhard Dietzschold, Eberhard Weihe

Department of Microbiology and Immunology Faculty Papers

Rabies virus (RABV) causes fatal encephalitis once it invades the central nervous system (CNS), and treatment options are extremely limited at this stage. We investigated the recombinant RABV variants SPBN, SPBNGA (glycoprotein substitution R333E), SPBNGAK (R333E plus N194K), SPBNGAS (R333E plus N194S), and TriGAS (three copies of the R333E/N194S glycoprotein). We evaluated their cellular tropism and immune activation in an intracerebral mouse infection model using immunohistochemistry and confocal immunofluorescence. SPBNGAK (R333E/N194K) resulted in mixed neuronal and astrocytic infection and lethal disease. In contrast, the R333E/N194S mutations in the GAS variants were associated with reduced neuronal infection and apparent astrocyte-restricted infection …

A Novel Strategy Of Mycorrhizal Fungi Usage To Enhance Crop Resilience In Saline Environments: Biopriming With Serendipita Indica, Tuğba Özteki̇n, Meli̇sa Ayişiği, Lale Yildiz Aktaş

Turkish Journal of Botany

Soil salinization is a critical global challenge, threatening agricultural productivity by imposing osmotic stress, ionic toxicity, and oxidative imbalance in plants. This study investigated the potential of Serendipita indica biopriming to enhance salt stress tolerance in maize (Zea mays L. cv. Simon) seedlings through comprehensive physiological and biochemical analyses under controlled conditions. Maize seeds were bioprimed with different concentrations of mycorrhizal fungi S. indica spores and exposed to varying NaCl concentrations (0, 50, 100, and 200 mM). Nonprimed maize seedlings had a gradual reduction in seed vigor index, reaching about 93.56% in 200 mM NaCl treatment. Under nonsaline conditions, S. …

Taxonomic Significance Of Stem And Leaf Anatomy And Pollen And Seed Micromorphological Characters In The Papaver (Poppy) Sect. Rhoeadium From Türkiye, Esengül Özkaymakoğlu, Osman Tugay, Yavuz Bülent Köse, Deni̇z Ulukuş, Bayram Atasagun, Meti̇n Armağan, Ferhat Celep

Turkish Journal of Botany

The poppy (Papaver) has beautiful flowers that attract the attention of not only taxonomists but also the public. However, it also presents several taxonomic problems. This study examines 13 taxa of Papaver sect. Rhoeadium, including the following species native to Türkiye: P. purpureomarginatum, P. dubium subsp. dubium, P. dubium subsp. laevigatum, P. arachnoideum, P. arenarium, P. commutatum subsp. euxinum, P. guerlekense, P. rhopalothece, P. stylatum, P. clavatum, P. syriacum, P. rhoeas, and P. postii. Plant specimens were collected from natural populations, and anatomical investigations were carried out on stem and leaf cross-sections. Pollen and seed features were examined using both …

Complete Genome Characterization Of A New Alphapartitivirus Identified In The Ectomycorrhizal Fungus Lactarius Mediterraneensis, Aigul Kali̇yeva, Ergi̇n Şahi̇n, Gülce Edi̇ş, Ilgaz Akata

Turkish Journal of Botany

Viruses that naturally infect fungi capable of forming mycorrhizal symbioses remain poorly studied. In the present study, a new partitivirus associated with the basidiomycete mycorrhizal fungus Lactarius mediterraneensis was identified and characterized, and it was designated as Lactarius mediterraneensis partitivirus 1 (LmPV1). The complete genome of LmPV1 was determined through high throughput sequencing of double-stranded RNA (dsRNA) extracts and confirmed by Sanger sequencing of RLM-RACE PCR amplicons. T he genome comprises two dsRNA segments, 1899 bp and 1957 bp, each containing a single open reading frame (ORF) a putative RNA-dependent RNA polymerase (RdRp) and a capsid protein (CP). Comparative analysis …

Partial Versus Full Revision In Cementless Single-Stage Exchange For Hip Periprosthetic Joint Infection: A Multicenter Comparative Study With 10-Year Survivorship Analysis, Wenbo Mu, Atthakorn Jarusriwanna, Boyong Xu, Scot A. Brown, Xiaogang Zhang, Alexander Dawes, Javad Parvizi Md, Li Cao

Rothman Institute Papers

BACKGROUND: Periprosthetic joint infection (PJI) is one of the most challenging complications following total hip arthroplasty (THA). Traditional management typically involves full revision to ensure comprehensive infection eradication. However, for patients with well-fixed implants, partial revision in a single-stage cementless approach may provide a viable alternative, potentially preserving bone stock and reducing operative time. The relative efficacy of this approach compared with full revision remains to be fully explored. This multicenter study aims to determine whether partial revision in cementless single-stage exchange surgery offers comparable infection control outcomes to full revision for select patients with well-fixed implants.

METHODS: We conducted …

Hormetic Doses Of Lead Metal Ion Stimulated Photosynthetic Attributes In Brassica Juncea  During Various Stages Of Growth, Shalini Dhiman, Arun Dev Singh, Nitika Kapoor, Renu Bhardwaj

Turkish Journal of Botany

Low doses of lead (Pb) ions were used in the present study to investigate their effects on photosynthetic efficiency in Brassica juncea. Plants of B. juncea grown for 30, 45, and 60 days were analysed for root and shoot length, pigment content, gas exchange, chlorophyll fluorescence, primary and secondary metabolites, and nonenzymatic antioxidant responses under exposure to hormetic doses of Pb2+. The findings show that low levels of Pb2+ (especially 18- and 36-µM Pb treatments) improve gas exchange metrics, chlorophyll fluorescence parameters, root and shoot growth, and increased amounts of chlorophyll, carotenoid, xanthophyll and low amounts of pheophytin as compared …

Mycorrhiza-Mediated Physiological Responses Of Shallot Against Twisted Disease And Drought Stress, Krisnanda Surya Dharma, Ani Widiastuti, Suryanti Suryanti

Turkish Journal of Botany

Shallot, a strategic horticultural commodity in Indonesia, is susceptible to biotic stress (e.g., twisted disease) and abiotic stress (e.g., drought). Mycorrhizal fungi offer an environmentally friendly solution to enhance plant resilience. This study evaluated the effects of mycorrhizal application on shallot plants against twisted disease (Fusarium acutatum) and drought stress. Using a randomized complete block design, we assessed growth, disease resistance, and physiological responses. Data were analyzed using analysis of variance followed by Tukey’s honestly significant difference test at a 95% confidence level. Results indicated that mycorrhizal application reduced both the severity and rate of twisted disease development in shallots. …

Unpacking A Health Paradox Among Preterm Infants: Insights From A Providers' Perception, Brittany Nicole Stewart

ETDs from 2020-2029

The goal of this dissertation is to examine the varying perspectives, or frames, of providers regarding decision-making in the NICU, which includes how they view neonates and their families, their roles as providers, and the way their frames possibly impact the care they give to the infants. In this dissertation, I conduct in-depth interviews with 34 NICU providers and professionals that provide their services in the NICU, including doctors, nurse practitioners, nurses, various therapists (i.e. respiratory, physical, occupational), and two other providers from two other professions. Within the NICU, a common stereotype exists that is a belief that White boy …

Oncofetal Reprogramming: A New Frontier In Cancer Therapy Resistance, Anh Nguyen, Molly Lausten, Bruce M. Boman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Oncofetal reprogramming has recently emerged as a critical concept in translational cancer research, particularly for its role in driving therapeutic resistance across a variety of malignancies. This biological process refers to a pattern of gene expression that is restricted to embryogenesis, but becomes expressed again in a subpopulation of cancer cells. These genes are typically suppressed after embryogenesis, and their aberrant re-expression in tumors endows cancer cells with stem-like properties and enhanced adaptability. The goal of this review is the following: (i) comprehensively examine the multifaceted nature of oncofetal reprogramming; (ii) elucidate its underlying molecular mechanisms, including its regulators and …

Updating Misev: When, What, How, And Why?, Naveed Akbar, Dylan Burger, Benedetta Bussolati, Edit Buzás, Randy Carney, Young-Eun Cho, Tom Driedonks, Juan Manuel Falcon-Perez, Yu Fujita, Deborah Goberdhan, An Hendrix, Yiyao Huang, Suresh Mathivanan, Mỹ Mahoney, Sujata Mohanty, Andreas Möller, Nicole Noren Hooten, Stefano Pluchino, Carlos Salomon, Ana Claudia Torrecilhas, Sara Veiga, Kenneth Witwer

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

No abstract provided.

Trapped And Traumatised: A Scoping Review Of The Psychological Sequelae Of Entrapment Following Motor Vehicle Collision, Thomas A.M. Dixon, Kara Hole, Louise Johnson, Tim Nutbeam

Peninsula Medical School

Background: Motor vehicle collisions (MVCs) are a significant public health challenge, resulting in substantial mortality and morbidity. Entrapment occurs in 12–33% of all MVCs and is associated with greater injury severity, longer on-scene time, and increased mortality. However, the psychological consequences of entrapment remain poorly characterised. Objectives: This scoping review seeks to establish the current understanding of the psychological sequelae of entrapment following MVCs and draws on insights from related fields of study in order to inform future research and clinical practice. Methods: A scoping review was undertaken following established methodological guidance. Searches were completed on NHS Knowledge and Library …

Conserved Chromatin Programs Orchestrate Cardiac Cell States In Health And Disease And Drive Cardiomyocyte Proliferation After Injury, Xiaoxiao Geng

ETDs from 2020-2029

Chromatin structure is a central regulator of gene expression and cellular identity, yet the chromatin structural factors driving cardiac disease and regeneration remain incompletely defined. This dissertation investigates how modulation of chromatin architecture shapes pathological and regenerative cardiac phenotypes through integrated single-cell transcriptomic, epigenomic, and functional analyses. To determine whether chromatin structural regulators distinguish healthy from diseased cardiac states, we curated a comprehensive list of chromatin structural genes and applied it to single-nuclei RNA sequencing datasets from human hearts with and without dilated cardiomyopathy (DCM). Chromatin structural gene expression effectively stratified cardiomyocyte and fibroblast populations by disease status. Diseased cardiomyocytes …

A Prevention Model For Delaware: Reducing Opioid Relapse After Release From Incarceration, Jaime Basara

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement

The goal of this Social Change Portfolio is to reduce relapse risk among individuals with opioid use disorder who are reentering society after their release from a Delaware correctional facility, by enhancing clinical continuity of care, including counseling, relapse-prevention planning, and linkage to community-based treatment programs.

Significant Findings

This portfolio aims to raise the awareness that justice-involved individuals with opioid use disorder in Delaware face extremely high rates of relapse, overdose, and death during the post-release period, particularly within the first few weeks and months after reentering society. This is often due to abrupt discontinuation of treatment, reduced …

An Application-Based Ontological Knowledge Base Of Medications To Support Health Literacy And Adherence For The Consumer Population: An Aging Population Use Case, Clifford Chen, Muhammad Amith, Kirk Roberts, Rebecca Mauldin, Renata Komalasari, Cui Tao

Faculty, Staff and Student Publications

No abstract provided.

Spartan Daily, January 29, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 4

Analysis Of Active Ingredients In Medicinal Herbs With High-Performance Liquid Chromatography And Related Technologies: A Review, T.-H. Tsai, C.-Y. Hong, C.-F. Chen

Journal of Food and Drug Analysis

An increasing number of analytical techniques have been brought to bear on the herbal drugs used in traditional Chinese medicine. This in turn has led to improved quality control of medicinal herbs, ingredient stability and shelf-life tests, ensurement of the concentrations of herbal drug ingredients in biological fluids, and pharmacokinetic studies. In the past decades, gas chromatography has been the method of choice for the analysis of volatile compounds, while liquid chromatography is a highly successful separation technique for nonvolatile molecules. Recently, high-performance liquid chromatography coupled with various column and detection systems have become some of the most important techniques …

A Strengths, Weaknesses, Opportunities, And Threats (Swot) Analysis Of Chatgpt In Academic Help-Seeking, Fan Yang

International Journal of Teaching and Learning in Higher Education

This study explores the use of ChatGPT as a help-seeking tool in educational contexts, examining both its potential benefits and costs through a SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis. The purpose is to provide a comprehensive understanding of the various internal and external factors that either promote or hinder the use of ChatGPT for academic help-seeking. The strengths of ChatGPT, such as its 24/7 availability to provide immediate responses, non-judgmental tone, and the ability to provide personalized help based on specific prompts, position itself as a valuable resource for help-seekers. However, the low quality of the responses generated by …

Seizing The "Organic" Moment: Cuba's Agricultural Crossroads And Certified Organic Export Potential, Wesley J. Hevia, Michael T. Olexa, Thomas T. Ankersen, William A. Messina Jr.

Florida Journal of International Law

Cuba has been referred to as "the world's first national experiment in sustainable agriculture." Given the critical shortages in chemical inputs to Cuba's agricultural sector following the loss of Soviet economic support and subsidization, this may well be a fitting description. Cuba's use of the term "organic" to describe some of its agricultural production can be misleading. Not all of Cuba's "organic" products would satisfy the organic certification requirements for most developed countries. That being said, Cuba is shipping certified organic fresh citrus and citrus juices into EU markets. With proper investments and implementation of the appropriate procedures and protocols, …

Environmental Legislation And Institutional Framework In Cuba, Daimar Cánovas González

Florida Journal of International Law

No abstract provided.

General Overview Of Cuban Family Law Legislation, Ana María Álvarez-Tabío Albo

Florida Journal of International Law

This Essay will take four routes that converge at multiple points. First, we will review the social context prevailing when the Family Code (Código de Familia) was promulgated on March 8, 1975, coinciding with International Women's Day. Afterwards, we will briefly refer to other pieces of legislation that complete the universe of judicial ordinances protecting the family. Next, we will dedicate more time to examining the fundamental characteristics of the principal institutions of Cuban Family Law. Finally, we will see the challenges that must be confronted in the prevailing reality in the Cuban family and society.

Instruments Of Environmental Governance: A Guarantee Of Substainability In Cuba, Dagniselys Toledano Cordero

Florida Journal of International Law

No abstract provided.

Pillars Of The Postgraduate Formation Of The Jurist In Cuba, Mayda N. Goite Pierre, Marta Fernández Martínez

Florida Journal of International Law

No abstract provided.

Review Of ““O Sisters Ain’T You Happy?” Gender, Family, And Community Among The Harvard And Shirley Shakers, 1781-1918”, Etta M. Madden

Communal Societies

No abstract provided.

Between Zion And Babylon. The Application Of The Total Institution Model To A Christian Charismatic Community: The Case Of The Jesus Fellowship, Stephen Hunt

Communal Societies

No abstract provided.

Families In Contemporary Intentional Communities: Diversity And Purpose, William L. Smith

Communal Societies

No abstract provided.