Digital Commons Network^™

Placental Clues To Congenital Heart Disease: A Modeling Approach, Ashley S. Howard, Selina M. Tucker, Kaela Varberg

Manuscripts, Articles, Book Chapters and Other Papers

Congenital heart disease (CHD) remains the most common birth defect and a leading contributor to global infant morbidity and mortality. Early diagnosis improves outcomes, yet current screening methods frequently miss CHD during routine prenatal screening. The placenta, which develops in parallel with the fetal heart and shares critical molecular pathways, represents an underexplored diagnostic tissue. We highlight clinical, epidemiological, and mechanistic insights that link placental abnormalities to CHD and explore how imaging, in vitro models, and multiomics can improve our understanding of the placenta–heart axis. Leveraging these tools will offer opportunities for earlier CHD detection and illuminate avenues for intervention …

Childhood Maltreatment And Deviations From Normative Brain Structure: A Mega-Analysis Of 3711 Individuals From The Enigma Major Depressive Disorder And Enigma Posttraumatic Stress Disorder Working Groups, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Background. Childhood maltreatment (CM), encompassing abuse and neglect, is highly prevalent and associated with elevated risk for major depressive disorder (MDD), posttraumatic stress disorder (PTSD), and other related conditions. However, the extent to which neuroanatomical alterations in MDD and PTSD are attributable to CM is uncertain.

Methods. Here, we analyzed CM and whole-brain magnetic resonance imaging (MRI) data from 3711 participants in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) MDD and PTSD Working Groups (25 sites; mean age = 33.3 ± 13.0 years; 59.9% female). Normative modeling estimated deviation z scores for 14 subcortical volume, 68 cortical thickness …

Defining The Society Of Pediatric Liver Transplantation (Split) Research Agenda: A Delphi Consensus Project., Sharad I. Wadhwani, Pooja Reddy Spector, Amy G. Feldman, Katryn N. Furuya, Kayla Hartjes, Chaowapong Jarasvaraparn, Beau Kelly, Stacee M. Lerret, Krupa Mysore, Arti Pawaria, Philip Rosenthal, Amy Shui, Voytek Slowik, Sarah Taylor, Jennifer Vittorio, Pamela L. Valentino, Society Of Pediatric Liver Transplantation (Split)

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Despite major advances in surgical and medical management, only one-third of pediatric liver transplant (LT) recipients remain morbidity-free at 10 years. The Society of Pediatric Liver Transplantation (SPLIT) published a research agenda over 10 years ago, and much progress has been made since then. An updated consensus-driven SPLIT research agenda could guide future research and funding priorities. We aimed to identify and prioritize key research needs across the continuum of pediatric LT care using a modified Delphi consensus approach.

METHODS: We conducted a three-round modified Delphi process among SPLIT members. In round 1, participants submitted open-ended research priorities. In …

Use Of A Cystatin C-Based Gfr Equation In A Population Pharmacokinetic Model Of Methotrexate Clearance In Adult Patients With Lymphoma., Zachary L. Taylor, Erin F. Barreto, Kristin C. Cole, Andrew D. Rule, Kianoush B. Kashani, Nelson Leung, Carrie A. Thompson, Thomas E. Witzig, Laura Ramsey, Jason N. Barreto

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: High-dose methotrexate (HDMTX) is a key treatment for lymphoma with central nervous system involvement. Whether incorporating cystatin C into glomerular filtration rate estimation improves methotrexate (MTX) clearance prediction remains unclear.

OBJECTIVES: We aimed to evaluate whether cystatin C-inclusive glomerular filtration rate equations improve MTX clearance prediction and to explore the relationship between MTX exposure and acute kidney injury (AKI) in adult patients with lymphoma receiving HDMTX.

METHODS: This was a prospective single-center study performed on 80 adult patients with lymphoma receiving HDMTX (1.5-8 g/m²) over a 4-h infusion. A population pharmacokinetic model was constructed using data from …

Impact Of Cyp2d6 Genotype And Inhibitor Use On Risperidone Metabolism In Children: Functional Insights Into The *17 And *29 Alleles., Matthew H. Bennett, Ethan A. Poweleit, Samuel E. Vaughn, Brandon Retke, Paul C. Toren, Jeffrey R. Strawn, Laura Ramsey

Manuscripts, Articles, Book Chapters and Other Papers

Risperidone, an atypical antipsychotic, is increasingly prescribed in pediatric patients with psychiatric disorders. It is primarily metabolized by CYP2D6 to 9-hydroxyrisperidone, an active metabolite associated with a higher risk of adverse effects. The CYP2D6*17 and *29 alleles are prevalent in individuals of African ancestry and less studied than variants found in European ancestry individuals. This knowledge gap contributes to differences in health outcomes in individuals of non-European origin. The primary objective of this study is to replicate recently identified risperidone-specific activity for the CYP2D6*17 and *29 alleles. During psychiatric hospitalization, CYP2D6 was genotyped as part of routine care. Remnant plasma …

Molecular And Regional Characterization Of Colorectal Polyps: Insights From Proteomics, Phosphoproteomics, And Immune Profiling., Thomas M. Attard, Shawn D. St Peter, Alexander Kats, Doug R. Lagemann, Caitlin E. Lawson, Badal C. Roy, Kafayat Yusuf, Lisa Harvey, Payel Bhanja, Rishi Man Chugh, Subhrajit Saha, Michael P. Washburn, Shahid Umar

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Familial adenomatous polyposis (FAP) is an inherited predisposition to colorectal cancer and characterized by profuse colorectal adenomas starting from the second decade of life. Regional (left vs. right) differences in the colonic microbiologic and immunologic microenvironment may impact adenoma evolution but are poorly understood. We aimed to characterize regional molecular, microbial, DNA damage, and immune differences in pediatric FAP polyps to test the hypothesis that polyps in pediatric FAP exhibit distinct regional and molecular features that contribute to differential growth and genomic instability.

METHODS: Colonic polyps and adjacent non-polyp mucosa were harvested from pediatric FAP patients undergoing colonoscopy. Tandem …

Stroke Increases Motor Output Variability During Maximal Voluntary Isometric Contractions Of Knee Extensor Muscles In Adults, Zhilun Zhou, Stephanie Christine Wolfe, Brian Schmit, Matthew J. Durand, Sandra Hunter, Allison Hyngstrom

Physical Therapy Faculty Research and Publications

Greater motor output variability (MOV, inconsistency and unsteadiness) during submaximal tasks post stroke is associated with poorer motor performance. However, little is known about MOV during maximal tasks and relationships with clinical measures of motor performance among stroke survivors. This study determined inconsistency (across discrete attempts) and unsteadiness (within a single attempt) during knee extension maximal voluntary isometric contractions (MVICs) in stroke survivors and neurotypical controls. Forty-three stroke survivors (28 female) and 31 age-matched neurotypical controls (15 female) performed a minimum of five knee extension MVICs with paretic and non-paretic legs (stroke) or dominant leg (controls). Inconsistency was calculated as …

Asset: Scaling Authentic Science Education, Alexandra Forgerson, Carol Colaninno, Rachel Ruggirello, Doug Chalker

Institute for School Partnership: Research & Publications

The Washington University in St. Louis (WashU) Advancing Secondary Science Education through Tetrahymena (ASSET) program is a long-standing science education program that was initially developed at Cornell University and transferred to WashU in 2023. Funded through the National Institutes of Health (NIH) Science Education Partnership Award (SEPA), the ASSET program enhances STEM education by providing research-based, inquiry-driven learning experiences for K-12 students. The program integrates phenomenon-based storylines aligned with the Next Generation Science Standards (NGSS) to promote critical thinking and engagement among students. All ASSET learning experiences feature a living model organism, Tetrahymena, a single-celled protozoan that is safe and …

Adapting Lessons From The Indian Subcontinent To Accelerate Elimination Of Visceral Leishmaniasis As A Public Health Problem In East Africa, Eva Iniguez, Daniel Masiga, Caryn Bern, Sridhar Srikantiah

All Peer-Reviewed Publications

This viewpoint draws lessons from the elimination of visceral leishmaniasis (VL) as a public health problem in the Southeast Asia region (SEAR) to inform efforts in East Africa (EA), now the global epicenter of Leishmania donovani transmission. VL is fatal and there is no licensed vaccine. Success in India relied on robust surveillance, rapid diagnosis, single-dose treatment, vector control, and multi-partner coordination. EA faces additional challenges than SEAR with multiple sand fly vectors, sensitive diagnostics and longer treatment regimens, high population mobility, and gaps in ecological and epidemiological knowledge. We highlight how strategies from South Asia could be adapted while …

Postcolonial Ecocriticism And The Recovery Of Hope: Okri, Dangarembga, And The Spiritual, John C. Hawley

English

This essay stages a comparative ecocritical reading of African and transnational texts—Cajetan Iheka’s Naturalizing Africa, Ben Okri’s Every Leaf a Hallelujah, Tsitsi Dangarembga’s This Mournable Body, Greg Sarris’s Becoming Story, and Karen Armstrong’s Sacred Nature—to examine how narrative re-situates the human within more-than-human worlds. Drawing on Iheka’s “aesthetics of proximity,” postcolonial theory, and critical posthumanism, it contrasts Okri’s hopeful, child-centered fable of multispecies reciprocity with Dangarembga’s portrayal of “slow violence,” psychic dispossession, and eco-touristic commodification in neoliberal Zimbabwe. Indigenous and spiritual frameworks in Sarris and Armstrong further disclose ancient precedents for posthuman ethics, foregrounding humility, …

Unhsc Scm Performance Fact Sheets, Unh Stormwater Center

UNH Stormwater Center

No abstract provided.

March 2026, Office Of Research

Research Update

No abstract provided.

Uab Libraries News, 03 2026, Uab Libraries

UAB Libraries News

No abstract provided.

Towards Socially Legitimized Trust In Ai-Learning Systems, Sanket Patole, Rob E. Carpenter, Reed M. Milewicz, Rose M. Baker, John R. Turner

Human Resource Development Faculty Publications and Presentations

AI-enabled learning technologies are rapidly becoming institutional infrastructure. In this context, “trust” cannot be treated as a simple user attitude or a byproduct of technical performance. We argue that durable trust in AI-enabled learning systems is fundamentally a legitimacy outcome: stakeholders must judge AI-mediated practices as appropriate, credible, and defensible within the normative and governance structures of learning environments. Building on socio-technical systems scholarship and institutional legitimacy theory, we introduce Socially Legitimized Trust (SLT), a framework that helps us understand adoption stability and contestation through alignment among three foundations: technocratic validation (credible evidence of capability, limits, and reliability), social validation …

Development And Evaluation Of The Interdisciplinary Graduate-Level Experiential Global Aging Education Program In The United States: A Case Of The Gerontology In Japan Course, Takashi Yamashita, Flavius R W Lilly, Diane B. Martin, Mio Kamijo

Journal of Global Education and Research

The cultural competence of the workforce is increasingly important due to global population aging and the growing diversity of the older population. Experiential learning, particularly through study abroad programs, is a known strategy to enhance these competencies; yet such training remains uncommon in higher education, especially at the graduate level. While the United States is currently a relatively young country with 17% of its population aged 65 years and older, the percentage is projected to increase to more than 21% by the end of this decade. Recognizing the value of learning from a super-aged society, a two-week study abroad course …

Bullying And Discrimination Experiences Of Bhutanese College Students: Prevalence, Impacts, And Responses, Kezang Sherab, John Howard

Journal of Global Education and Research

Prior studies as well as media reports have identified bullying and discrimination amongst Bhutanese school and college students as a cause of concern, especially so for a nation with Gross National Happiness as its goal. Bullying and discrimination are associated with negative outcomes and can impact overall well-being. This quantitative study examined bullying and discrimination amongst college students (n = 16) in Bhutan through a self-administered online survey to a representative sample of 2043 (male = 40.8%; female = 55.8%). There was a non-significant decline from the 2016 survey in the reported prevalence of being bullied (from 45.2% to …

Neutrophil-To-Lymphocyte Ratio As A Prognostic Factor Of Survival Outcomes In Head And Neck Squamous Cell Carcinoma Receiving Neoadjuvant Immunotherapy, Pablo Llerena, Praneet C. Kaki, Kathryn Nunes, Eric Mastrolonardo, Kelly Bridgham, Annie Moroco, Hani Samarah, Mouadh Barbirou, David Baek, Chun Wang, Voichita Bar-Ad, David Cognetti, Joseph Curry, Jennifer M. Johnson, Hushan Yang, Larry A. Harshyne, Adam J. Luginbuhl

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

PURPOSE: The neutrophil-to-lymphocyte ratio (NLR) is a prognostic marker in cancers treated with immune checkpoint inhibitors (ICI), reflecting the link between inflammation and cancer immune response. This study examines NLR's prognostic value in head and neck squamous cell carcinoma (HNSCC) patients receiving neoadjuvant ICI therapy, focusing on its potential as an independent predictor of overall survival (OS) and disease-free survival (DFS).

METHODS: We conducted a retrospective cohort study including three neoadjuvant trials: durvalumab ± metformin, nivolumab ± tadalafil, or nivolumab ± BMS-986205 from 2017 to 2022. Pre-treatment NLR was calculated using absolute neutrophil and absolute lymphocyte counts obtained before neoadjuvant …

Building Connections With Graduate Students Through Credit-Bearing Instruction, Michelle Desilets, Kimberly Pendell

Library Faculty and Staff Publications and Presentations

Graduate students often need support with research skills and other professional development that is under-recognized by their programs. Librarians play a key role in helping students fill in these gaps. This case study reviews student feedback on a librarian-developed and -delivered credit-bearing course. The course, Library Research and Scholarly Communication Fundamentals, is offered to graduate students across all disciplines. The curriculum is flexible and applicable to each student’s research, covering topics such as researching literature, citation and data management, and publishing in scholarly journals. The course has generated positive and constructive feedback from students, encompassing themes of self-efficacy, improved research …

Moving Forward: Teachers Managing Challenges And Change, Victoria A. Oglan, Lauren Gehr

South Carolina Association for Middle Level Education Journal

Teaching requires adapting to ongoing changes in pedagogy and technology, a reality intensified by the COVID-19 pandemic. This article situates pandemic-era instructional shifts within a broader history of educational change and reviews contemporary professional texts addressing technology integration, artificial intelligence, literacy instruction, teacher clarity, and deep learning.

Middle School Magic: Building Belonging And Brain-Aligned Classrooms, Christopher S. Culver, Katie Kinder

South Carolina Association for Middle Level Education Journal

Middle school represents a critical developmental period when belonging, identity, and emotional regulation converge to shape academic and social outcomes. This article explores how belonging and brain-aligned kindness transform classroom culture through connection, collaboration, compassion, and the Science of Kindness. Drawing from recent neuroscience, educational psychology, and classroom practice, the authors demonstrate how these principles activate neural pathways of safety, motivation, and empathy that enhance learning and well- being. Integrating research with actionable classroom strategies, this article illustrates how small, consistent acts of care, such as greeting students by name, fostering collaborative learning, building relationships in trust, and practicing restorative …

Scamle Journal 2026 Full Volume

South Carolina Association for Middle Level Education Journal

No abstract provided.

Histologic Analysis Of Peri-Implant Soft Tissue Around External Hexagon And Morse Taper Implant Connections, Daniel Sartorelli Marques De Castro, Jefferson David Melo De Matos, Jozely Francisca Mello Lima, Guilherme Da Rocha Scalzer Lopes, Mário Alexandre Coelho Sinhoreti, Daher Antonio Queiroz, Carlos Do Reis Pereira De Araújo

Faculty, Staff and Student Publications

Background: Twenty patients rehabilitated with screw-retained full-arch implant-supported prostheses functioning for at least one year were included.

Material and methods: This clinical study included 20 patients rehabilitated with screw-retained full-arch implant-supported prostheses in function for at least 1 year. Participants were allocated into two groups according to the implant-abutment connection design: external hexagon (EH; n = 10) and Morse taper (MT; n = 10). One peri-implant soft tissue biopsy specimen was obtained from each patient and processed for hematoxylin-eosin staining. Histological evaluation assessed epithelial hyperplasia, epithelial organization, inflammatory infiltrate intensity, and connective tissue fibrosis. Data normality was assessed using the …

Key Predictors Of Postpartum Depression And Anxiety Symptoms Among Mothers In Kilifi, Kenya: A Machine Learning Approach, Faith Benson, Rachel Odhiambo, Willie Brink, Anthony Ngugi, Akbar Waljee, Eileen Weinheimer-Haus, Cheryl Moyer, Ji Zhu, Amina Abubakar

Institute for Human Development, East Africa

Background:

The burden of maternal postpartum depression and anxiety is disproportionately high in sub-Saharan Africa (SSA), yet the use of advanced analytical methods to capture the complex interplay of variables influencing these conditions remains underexplored.

Objective:

To apply machine learning (ML) methods to predict depressive and anxiety symptoms in postpartum mothers and to identify key and actionable predictors.

Methods:

This cross-sectional study included 1,995 biological mothers of singleton infants aged 0–6 months, using survey data collected between March 2023 and March 2024 in Kaloleni and Rabai sub-counties, Kilifi County, Kenya, within the Kaloleni–Rabai Health and Demographic Surveillance …

Emerging Options And Future Strategies In Immunotherapy For Advanced Lung Squamous-Cell Carcinoma, Y Wang, R Rosell, F R Hirsch, S Lu, R Govindan, K Park, S Peters, J J Zhang

2020-Current year OA Pubs

Advanced-stage lung squamous-cell carcinoma (LUSC) remains a therapeutic challenge. Although immune checkpoint inhibitors (ICIs) have revolutionized LUSC treatment, only a small subset of LUSC patients can achieve durable clinical benefits, underscoring the need for novel strategies. Emerging immunotherapy strategies have demonstrated early evidence of promise for LUSC patients, particularly multi-specific antibodies and fusion proteins, antibody-drug conjugates, adoptive cell therapies, and cancer vaccines. Additionally, advances in multi-omics and artificial intelligence offer potential for precise immunotherapy by deciphering the complex tumor-immune microenvironment and predicting therapeutic responses. The future of LUSC treatment lies in rational multi-target and biological therapies to boost immune cytotoxicity, …

Single-Cell Multi-Omic Techniques Highlight The Diverse Composition And Intercellular Interactions Of The Vestibular Schwannoma Tumor Microenvironment, Shree S Pari, Sangami Pugazenthi, Albert H Kim, Bhuvic Patel

2020-Current year OA Pubs

Vestibular schwannomas (VS) are tumors arising from Schwann cells of the vestibulocochlear nerve, often leading to hearing loss, gait imbalance, and other neurological complications. Recently, molecular profiling of VS using bulk and single-cell transcriptional and epigenetic approaches has reshaped our understanding of VS pathogenesis and challenged the long-standing view of VS being molecularly homogeneous. These integrative, multi-omic approaches reveal significant differences within VS and highlight diverse Schwann cell subpopulations and their interactions with the tumor microenvironment. Interestingly, these analyses also uncover 2 molecularly distinct groups of VS, one containing Schwann cells with an "Injury-like" phenotype that drives VS progression through …

Finding Significant Hits In Networks: A Network-Based Tool For Analyzing Gene-Level P-Values To Identify Significant Genes Missed By Standard Methods, Sandeep Acharya, Vaha Akbary Moghaddam, Wooseok J Jung, Yu S Kang, Shu Liao, Michael A Province, Michael R Brent

2020-Current year OA Pubs

Finding Significant Hits in Networks (FISHNET) uses prior biological knowledge, represented as gene interaction networks and gene function annotations, to identify genes that do not meet the genome-wide significance threshold but replicate, nonetheless. Its input is gene-level P-values from any source, including omicsWAS, aggregation of genome-wide association studies P-values, CRISPR screens, or differential expression analysis. It is based on the idea that genes whose P-values are low purely by chance are distributed randomly across networks and functions, so genes with suggestive P-values that cluster in densely connected subnetworks and share common functions are less likely to reflect chance and more …

Accuracy And Reliability Of Artery-Vein Differentiation In Small-Field Macular Oct Angiography, Haneen Alfauri, Tugce Ilayda Turer, Cyriac Manjaly, Aditya Santoki, Senyue Hao, Marin Woronets, Chao Zhou, Rithwick Rajagopal

2020-Current year OA Pubs

PURPOSE: Accurate artery-vein (AV) differentiation in small-field macular optical coherence tomography angiography (OCTA) remains challenging due to a lack of standardized guidelines. We propose and validate criteria for

APPROACH: Small field-of-view (FOV) OCTA scans were analyzed using established AV criteria for large-field (

RESULTS: A total of 465 vessels from 20 healthy eyes were evaluated across 3 pseudo-branching orders using the criteria for OCTA. Annotators achieved high accuracy (95.1%, 92.3%) and strong intra/inter-rater reliability (

CONCLUSIONS: Accurate and reproducible AV labeling is feasible in

Mapping Charge Interactions In Intrinsically Disordered Proteins, Michael Phillips, Andrea Holla, Magdalena Wojtas, Aritra Chowdhury, Andrea Sottini, Sebastian L B König, Natalie Mutter, Nick Lamb, Jonathan Huihui, Monika Lopko, Andrea Soranno, Daniel Nettels, Andrzej Ożyhar, Benjamin Schuler, Kingshuk Ghosh

2020-Current year OA Pubs

Intrinsically disordered proteins (IDPs) are often rich in charged residues, and electrostatic interactions have a pronounced effect on their conformational distributions, interactions and functions. However, attaining quantitative understanding of electrostatics is challenging because of the sequence-specific arrangement of charges in the chain, the long-range nature of electrostatic interactions, charge screening, and the condensation of counterions-effects that all need to be taken into account self-consistently. Here, analytically tractable quantitative models are developed to predict ensemble average distances between any pair of residues in IDPs as a function of sequence and salt concentration, explicitly considering charge patterning. These models are tested systematically …

Rooted And Rising: A Case Study Of Chinese American Undergraduates' Career Pathways At A Pwi Post-Covid, Rebecca Yin-Chow Martinez

Theses & Dissertations

In the wake of the COVID-19 pandemic, Chinese American undergraduate students have navigated complex intersections of intergenerational expectations, racialized experiences, and evolving career aspirations within higher education. This qualitative case study explores how Chinese American undergraduate students at a predominantly white institution (PWI) choose their educational and career goals in a post-COVID climate. Guided by the Asian American Intergenerational Model of the Psychology of Working (AAIM), this study examines the influence of familial expectations, personal interests, institutional supports and barriers, and experiences of racism on students’ career decision-making processes. Data was collected through semi-structured interviews, a focus group, observations, Career …

Devaluation Insensitivity Of Event Related Potentials Associated With Food Cues, Thomas D. Sambrook, Andy J. Wills, Ben Hardwick, Jeremy Goslin

School of Psychology

Eating in the absence of hunger represents a failure of homeostatic mechanisms responsible for energy balance and is a cause of obesity. The pervasive presence of food cues in the modern environment may play a role in this phenomenon. The present study used the technique of satiety-specific selective devaluation to investigate eating in the absence of hunger in the context of a reinforcement learning task. While participants’ performance on the task suggested that food on which they had sated no longer held value for them, event related potentials following images of the food were unaffected by the devaluation. Food cues …