Digital Commons Network^™

Impact Of Plasma Ptau181 Levels On Clinician Diagnostic Confidence And Management In Memory And Cognition Clinics: A Multi-Site Before-And-After Study, Johannes C. Michaelian, Azadeh Feizpour, James C. Vickers, Jane E. Alty, Jessica M. Collins, Vincent Doré, Catriona Ireland, Anna E. King, Ralph N. Martins, Michael Woodward, Sharon L. Naismith, Christopher C. Rowe

Research outputs 2022 to 2026

Introduction: Recent advances allow blood tests to detect key proteins linked to Alzheimer's disease (AD). Methods: In this before-and-after study across three Australian memory and cognition clinics, we evaluated the impact on clinicians' diagnostic confidence and management following disclosure of routine patients' AD probability, using predefined plasma phosphorylated tau 181 (pTau181) thresholds set at 90% sensitivity and 90% specificity for amyloid-beta (Aβ) positron emission tomography (PET) positivity. Results: One hundred thirteen participants (mean age: 71.2 ± 8.4; mean Mini-Mental State Examination score: 27.7 ± 2.5) with dementia (n = 17, 15.0%), mild cognitive impairment (n = 48, 42.5%), and subjective …

Redbird Scholar, Vol. 11, No. 2 (Spring 2026), Illinois State University, Office Of The Vice President For Research And Graduate Studies

Redbird Scholar

No abstract provided.

Non-Invasive Intracranial Pressure Estimation In The Intensive Care Unit: Narrative Review Of Methods And Clinical Applications, Edoardo Picetti, Daniele Guerino Biasucci, Elisa Gouvea Bogossian, Sérgio Brasil, Danilo Cardim, Marek Czosnyka, Daniel A Godoy, Gregory W J Hawryluk, Mohammad I Hirzallah, Frank A Rasulo, Carla Bittencourt Rynkowski, Andres M Rubiano, Fabio Silvio Taccone, Chiara Robba

Faculty, Staff and Students Publications

Despite invasive methods are the gold standard for intracranial pressure (ICP) measurement, several non-invasive techniques (nICP) have been proposed as surrogate, although their use remains insufficiently recognized in clinical practice. These include transcranial Doppler blood flow velocity  assessment (arterial or venous), optic nerve sheath diameter (ONSD), automated pupillometry, measurement of skull expansion and compliance, brain imaging, double-depth ophthalmic artery blood flow velocity, and ultrasound time-of-flight. The main limitations of all indirect methods are calibration and zeroing, which constrain the absolute accuracy of non-invasive ICP monitoring. For transcranial Doppler-based methods, the 95% limits of agreement are approximately ± 7-15 mmHg, while …

Qualitative And Quantitative Analysis Of The Sk-3 I398 Interval In Neurospora Crassa, Tapasvi Bhatt

Senior Theses – Biological Sciences

Spore killer-3 (Sk-3) is a selfish genetic element on Chromosome III of Neurospora that biases its own transmission by killing meiotic products that fail to inherit the element. Although the resistance component of Sk-3 is known, the killer has not been identified. Previous deletion mapping confined the candidate killer region to a small block of DNA near interval i350 and suggested that the nearby 178 bp interval i398 might show different behavior in qualitative versus quantitative assays. The goal of this thesis was to construct and analyze an Sk-3 i398Δ strain and determine whether deletion of i398 …

Characterising Soil Microbial Communities In Thinned And Unthinned Eucalyptus Forest In Southwestern Australia, Aaron J. Brace, Laurence Dugal, Josephine Hyde, Kristen Fernandes, Anna J.M. Hopkins, Emma Stevens, Gavan S. Mcgrath, Katinka X. Ruthrof

Research outputs 2022 to 2026

Climate change stress in forested ecosystems globally has led to die-off events, and management actions are needed to help mitigate these pressures. Forest thinning has been proposed to reduce competition for moisture between trees, however, the effects of forest thinning on lesser-studied organisms, such as soil microbial communities, need quantification. Soil microbial communities are essential for processes such as nutrient cycling and can be used as indicators of below-ground health and as an overall proxy for biodiversity. This study examined soil microbial communities, and site and soil characteristics, directly at the base of trees and in inter-tree spaces in a …

Apoe-Stratified Proteomic And Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation And Lipid Dysregulation In Alzheimer's Disease, Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M Holtzman, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for Alzheimer's disease (AD). However, it is known that other pathways independent of APOE also play a role in AD. Disentangling APOE-dependent and independent effects is instrumental for understanding the biology of AD. We conducted an APOE-stratified multi-omic analysis in multiple large datasets to identify AD-associated plasma proteins and metabolites. More than 64% of the identified proteins were not found in non-APOE stratified studies, and 17% of the proteins showed APOE-specific trends. Mitochondrial dysfunction was associated in AD independently of APOE and was accompanied by disruptions in glucose and lipid …

Visual Recognition Of The Anteroposterior Female Body Axis Drives Spatial Elements Of Male Courtship In Drosophila, Ross M Mckinney, Christian Monroy Hernandez, Yehuda Ben-Shahar

2020-Current year OA Pubs

Drosophila males exhibit a highly stereotypic courtship ritual toward virgin females, which is comprised of a sequence of specific behavioral elements that depend on inputs from diverse sensory modalities. Particularly, the visual system of the male plays an important role in detecting salient patterns, colors, and motion cues from conspecifics, which can promote or inhibit specific aspects of male courtship such as chase and song production. Here, we use a computer vision and machine learning-based approach, with a simplified courtship paradigm, to show that males also depend on visual cues to determine the anterior-posterior body axis of females, which drives …

Multicenter Evaluation Of Ceftazidime/Avibactam In Pediatric Patients Across The United States: Real-World Insights Into The Management Of Drug-Resistant Gram-Negative Infections, Taylor Morrisette, Christine R Lockowitz, Valerie Yuenger, Evan E Facer, Et Al.

2020-Current year OA Pubs

BACKGROUND: Antimicrobial resistance among gram-negative pathogens is a global threat, with children particularly vulnerable due to limited treatment options and age-specific clinical outcomes data. Ceftazidime/avibactam (CZA) is effective against resistant gram-negative bacteria and demonstrates high success rates in adults; however, pediatric data remain limited. This study examined CZA use in children across United States medical centers.

METHODS: This multicenter, retrospective, observational cohort study included pediatric patients (< 18 years) who received ≥48 hours of CZA for suspected or confirmed gram-negative infections between February 2015 and October 2023. The primary outcome was clinical success, defined as occurrence of all 3 components: (1) absence of all-cause mortality within 30 days of CZA initiation, (2) absence of microbiologic and clinical recurrence within 30 days of CZA discontinuation, and (3) resolution or improvement of infection-related signs and symptoms during CZA therapy without modification of therapy due to clinical failure. Secondary outcomes included adverse events attributable to CZA and resistance development to CZA.

RESULTS: One-hundred patients were included, with most receiving CZA for targeted therapy (67%). The median (IQR) age and weight were 9.8 (1.9-15.9) years and 24.2 (12.2-49.9) kg, respectively. Nearly all patients (88%) had …

Neurofibromatosis Type 1-Plexiform Neurofibromas: Integrating Treatment Across Pediatric And Adult Populations, Amy E Armstrong, Andrea M Gross, Laura J Klesse, Steven D Rhodes, Shivani Ahlawat, Verena Staedtke, Camilo A Molina, Angela C Hirbe

2020-Current year OA Pubs

Plexiform neurofibromas (PNs) are a hallmark of neurofibromatosis type 1 (NF1), affecting ∼50% of individuals with the condition. Originating from Schwann cells and other peripheral nerve sheath components, these tumors can cause significant morbidity, including functional impairment, diminished health-related quality of life, chronic pain, and malignant transformation. Managing NF1-PNs is challenging because of disease variability, differing growth rates, and age-related differences in clinical presentation and treatment tolerability. This review examines current therapeutic strategies, including surgery, medical therapies, and emerging treatments, emphasizing individualized care. Highlighted here is the need for age-specific treatment planning, particularly as disease progression, comorbidities, and side-effect profiles …

Alterations In Ascending Aortic Hemodynamics And Aortic Length Correlate With Sex-Specific Thoracic Aortic Aneurysm Dilation And Lifespan In A Mouse Model Of Severe Marfan Syndrome, Krashn Kr Dwivedi, Yufan Wu, Marisa S Bazzi, Hadi Wiputra, Jacob Rother, James D Quirk, Victor H Barocas, Jessica E Wagenseil

2020-Current year OA Pubs

Thoracic aortic aneurysm (TAA) is a dilation of the aorta that may eventually dissect and/or rupture. It is associated with genetic disorders such as Marfan syndrome (MFS) and is a life-threatening cardiovascular condition if left untreated. Current clinical guidelines for TAA management are primarily based on maximum diameter thresholds that are often inadequate, particularly in MFS patients. Moreover, the diameter thresholds are not sex-specific, despite growing evidence that TAA outcomes in MFS are influenced by sex. The aim of this study was to identify non-invasive biomarkers for better management of TAA using male and female mice that are a genetic …

Accurate Predictions Of Disordered Protein Ensembles With Starling, Borna Novak, Jeffrey M Lotthammer, Ryan J Emenecker, Alex S Holehouse

2020-Current year OA Pubs

Intrinsically disordered proteins and regions (collectively IDRs) are found across all kingdoms of life and have critical roles in virtually every eukaryotic cellular process

Plant-Mediated Green Synthesis Of Zinc Ferrite Nanoparticles: Mechanisms, Properties, And Advanced Applications In Environmental And Biomedical Fields, Rihab Jabbar

Al-Bahir

Recently, plant-mediated green synthesis has emerged as a sustainable, eco-friendly, and cost-effective strategy for synthesizing zinc ferrite (ZnFe₂O₄) nanoparticles (NPs). This review critically examines the advancements in biosynthesizing ZnFe₂O₄ NPs using various plant extracts, including Aloe vera, Hibiscus rosa-sinensis, Aegle marmelos, Eucalyptus leaves, Tragacanth gum, Piper nigrum, and Moringa oleifera, among others. It emphasizes their dual role as reducing, capping, chelating, and stabilizing agents. The article extensively compares physicochemical properties of the green-synthesized NPs in terms of crystallite size, morphology, magnetic behavior, and band gap energy. Achieved through different synthesis routes such as sol-gel, hydrothermal, co-precipitation, and microwave-assisted methods. …

Stock Assessment Of The Dusky Spine Foot Siganus Luridus From The Gulf Of Aqaba, Egypt, Using A Length-Based Bayesian Biomass (Lbb) Method, Azza A. El-Ganainy, Abdel-Kader M. Hassan, Hussein A. El-Naggar, Hassan M. M. Khalaf-Allah, Ahmed M. El-Sadek

Blue Economy

The dusky spinefoot, Siganus luridus (Rüppel, 1829), stands as one of the most economically significant herbivorous species inhabiting the coral reefs of the Gulf of Aqaba, Egypt. Despite its prominence, our understanding of its biology and population structure remains limited. Thus, this study marks the first attempt to shed light on the demographic structure and stock assessment of S. luridus in the Aqaba Gulf. Over the span of January to December 2018, a total of 649 specimens were meticulously collected on a monthly basis from three landing sites (Nuwebaa, Dahab, and Abu Galum) within the Gulf of Aqaba, primarily utilizing …

Recombinant Gelonin: Purification And Functional Validation For Electroporation-Assisted Delivery, Eleni Zivla, Giedrė Šilkūnienė, Andrei G. Pakhomov, Mantas Šilkūnas, Olga N. Pakhomova

Knowledge and Creativity Expo

Type I ribosome-inactivating proteins, such as gelonin, are enzymatically potent toxins but are effectively non-toxic under physiological conditions because they are unable to cross the plasma membrane[1]. Pulsed electric fields (PEF) overcome this delivery barrier by transiently permeabilizing the plasma membrane, allowing direct cytosolic entry. This enhances gelonin cytotoxicity by several thousand-fold, highlighting gelonin’s potential as an electrochemotherapy candidate[2]. Here, we present a recombinant gelonin (rGel) expression platform in E. coli with HPLC-based purification that enables reproducible protein production and structure-guided engineering.

The mature gelonin sequence (residues 47–297) was cloned into pET-32a(+) with an N-terminally fused Trx-6×His tag and TEV …

A Renewed American Conservativism Or The End Of The American Republic?, Virgile Samba Moussinga

Helms School of Government Spring Public Policy Conference

No abstract provided.

The Tribal Energy Act: A Necessary Step Toward The Electrification Of The Navajo Nation, Carington Lowe, Michael Hamersky

Pepperdine Law Review

The Navajo Nation stands as a sovereign nation, yet many families still lack access to electricity because of enduring historical, structural, and regulatory barriers. This Article identifies the legal and technical barriers that have hindered meaningful progress and argues that supplementing the utility grid with distributed energy resources, such as biodigesters, offers a viable path toward electrification, particularly for remote and rural communities within the Navajo Nation. Biodigesters convert organic waste generated through community practices, such as sheep raising, into biogas through an anaerobic process. This form of energy reflects circular economy principles while also aligning with Diné cultural practices …

Telemedicine Kiosks: Can Technology Solve Rural Mississippi's Healthcare Crisis?, Babu George, Martha Ravola

Journal of Public Health in the Deep South

Background: Mississippi’s rural counties face hospital gaps, clinician shortages, and limited broadband/device access that collectively delay care and constrain telehealth uptake.

Purpose: This paper assesses whether telemedicine kiosks can improve rural healthcare access in Mississippi while also supporting viable local entrepreneurship and community development.

Methods: A conceptual, policy-and-market analysis integrated narrative literature synthesis, secondary data and policy review, and 5-year financial modeling under two cost-allocation scenarios: an Operator Model (subscription fees covered by partners/grants) and a Network Model (subscription fees borne by the kiosk operator).

Results: Kiosks with embedded connectivity and diagnostic peripherals can deliver device-independent virtual care and directly …

Advanced Manufacturing And Materials Of A Biomimetic Hoof For Space Robotics Applications, Benjamin Heckel

Student Research Symposium (SRS)

Planetary surfaces often feature steep, uneven, and unpredictable terrain conditions that resemble some of the most challenging natural environments on Earth. In these terrestrial settings, certain animals have evolved to navigate complex landscapes with remarkable agility. One such example is the mountain goat, an animal whose hooves have evolved for stable and precise movement across rocky, inclined surfaces. This biological adaptation provides a useful model for improving robotic mobility in planetary exploration. This study draws inspiration from that natural adaptation to develop a bio-mimetic robotic hoof designed to enhance traction, durability, and adaptability for extraterrestrial exploration. By replicating the mechanical …

Development Of A 3d Lung Epithelial Model To Study Pseudomonas Aeruginosa Infection Under Simulated Microgravity, Mariposa C. Magee

Student Research Symposium (SRS)

The human immune system is complex and highly responsive to physiological stress, especially when subjected to spaceflight conditions. Spaceflight conditions have shown to increase the risk of opportunistic infections such as Pseudomonas aeruginosa. This clinically relevant, gram-negative pathogen has been found in space flight-related environments such as on the International Space Station. Individuals in spaceflight environments are prone to experiencing immune dysfunction and altered cytokine profiles and could be at a greater risk for developing an opportunistic infection such as P. aeruginosa during the duration in spaceflight. P. aeruginosa poses a threat to individuals both on Earth and in spaceflight …

Hybrid Hierarchical Swarm Robots For Planetary Exploration, Eeman Abid

Student Research Symposium (SRS)

This project proposes a novel approach to planetary exploration utilizing a hybrid hierarchical swarm robotic system inspired by social insect colonies. The project will develop a centralized 'queen' robot that provides high-level direction to a team of semi-autonomous 'worker' robots, each capable of making local decisions while following the queen's strategic guidance. This structure aims to enhance adaptability and efficiency by balancing centralized coordination with decentralized execution. The approach aligns with NASA's CADRE mission, which uses coordinated rovers to map the lunar surface. By combining simulation in ROS2/Gazebo with physical testing on lunar regolith simulant, this research will evaluate how …

Investigating T-Cell Responses In Simulated Space Flight, Graema Grainger

Student Research Symposium (SRS)

In space flight, medication can be a large expense to take into space. Not only the weight but the conditions may cause some medication to expire on a long-term mission. This issue is compounded by how our immune systems decline in long term space exposure. It is important to understand in what ways the immune system is affected and why it’s happening. This study explores how space flight and gamma radiation cause inflammation and how neutrophil maturity and metabolic profile play a role in it. Space flight was simulated on 24-week-old mice, both male and female, in isolated, paired and …

Metabolomics In Precision Medicine: Application And Prospect In Cancer Research, Ming-Shi Shiao

Journal of Food and Drug Analysis

Metabolomics is the most recent and final discipline among the post-genomic, multiomics fields. It encompasses key technologies in systems biology, providing an overview of low-molecular-weight metabolites while examining disturbances to offer pathophysiological explanations. The two key analytical tools in metabolomics are nuclear magnetic resonance spectroscopy and mass spectrometry, which includes gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. Metabolomic research relies on a three-stage data generation process: the first stage involves precise analytical chemistry to produce data; the second stage employs multivariate statistical analysis; and the last stage uses big data as a reference for comparison to establish biochemical, metabolic, and …

Mass Spectrometry-Based Metabolomics For Studying Gut Microbiota-Derived Metabolites In Biological Samples, Ya-Ting Lin, Huai-Hsuan Chiu, Chih-Ning Cheng, Ching-Hua Kuo

Journal of Food and Drug Analysis

Gut microbiota produces a wide range of metabolites and plays a critical role in maintaining host health. Dysregulation of these metabolites can influence host metabolism through systemic circulation, contributing to the development of various diseases, including immunological, neurological and cancer-related disorders. Chromatography coupled with mass spectrometry (MS) has emerged as a powerful analytical approach, offering high sensitivity and resolution for studying gut microbiota-related metabolites. This review provides a comprehensive overview of chromatographic MS-based methods applied to the study of the gut microbial metabolome. We summarize strategies for sample collection, storage, and preparation of commonly analyzed sample types, including feces, plasma/serum, …

Special Issue: Analytical Technologies In Metabolomics: Applications And Future Prospects, Sung-Fang Chen

Journal of Food and Drug Analysis

No abstract for this article type.

Feather And Freedom: A Fabled Land In The Mind, Yuan Tao

Living in Languages

Set in the deceptively tranquil Honest Town, “The Feather of Sister Zandan” is narrated from the perspective of Zaan, a younger brother, revealing his complicated feelings toward his sister. Written in a fable-like style infused with magical realism, the story explores the tension between restraint and longing, culminating in an abrupt and poignant ending that evokes the emotional sting of an O. Henry-style twist. The short story won the Gemini Prize for Short Fiction of China in 2021. According to the award citation, Lan Du’s writing demonstrates emotional depth, dazzling imagination, and striking narrative tension. Her storytelling defies conventional …

Antibiotic Use And Resistance: Knowledge, Awareness, Attitudes, And Misconceptions Among Secondary School Students In Al Ain, Patil Arsen Maradian

Thesis/ Dissertation Defenses

This thesis explores students' knowledge, awareness, attitudes, and misconceptions regarding antibiotic use and resistance in secondary school. Since antibiotic resistance is both a biological threat and a general health problem influenced by educational and sociocultural factors, the objectives of the research are to determine the level of antibiotic-related knowledge and to assess how a particular pattern of intuitive reasoning can lead to entrenched misconceptions. The mixed-method design implemented in this study combined a survey based on the World Health Organization’s Antibiotic Resistance Multi-Country Public Awareness Survey, along with other validated instruments and qualitative research in the form of interviews in …

2023 Child Fatality Annual Report, Tennessee. Department Of Health.

Child Fatalities in Tennessee Report

No abstract provided.

On The Extreme Complexity Of Certain Nearly Regular Graphs, Gregory P. Constantine, Gregory C. Magda

Theory & Applications of Graphs

The complexity of a graph is the number of its labeled spanning trees. It is demonstrated that the seven known triangle-free strongly regular graphs are graphs of maximal complexity among all graphs of the same order and degree; their complements are shown to be of minimal complexity. A generalization to nearly regular graphs with two distinct eigenvalues of the Laplacian is presented. Conjectures and applications of these results to biological problems on neuronal activity are described.

Charter Schools Annual Report 2023, Tennessee. Department Of Education.

Charter Schools Annual Report

No abstract provided.

Perspective In Biomedical Sciences Field: Education And Career, Fitra Adi Prayogo, Mellyaning Oktaviani Sonya Kirana Sari, Isy Royhanaty, Poppy Fansisca Amelia, Heni Wijayanti, Ni Nyoman Maryaningtyas Adinatha, Dyah Wulandari, Anto Budiharjo

Chulalongkorn Medical Journal

Abstract

Background: The biomedical sciences represent a dynamic and multidisciplinary field pivotal to advancing human health through research, education, and innovation.

Objective(s): This review explores the evolving landscape of biomedical education and career pathways, driven by technological advancements, interdisciplinary integration, and global health demands.

Methods: We examine the distinctions between biomedical science, biomedicine, and biomedical engineering, highlighting their historical origins and contemporary roles. The education and career trajectories of biomedical laboratory scientists (BLS) are analysed, emphasising diverse competencies, core curricula, and the impact of regional policies on professional qualifications. Emerging trends and ethical/regulatory challenges are discussed.

Result(s): Key trends include …