Digital Commons Network^™

A Descriptive Survey Of Reef Fish Biodiversity At The Erojacks Artificial Reef, Dania Beach, Florida, Daniella Michelle Acosta Reyes

Undergraduate Student Symposium

South Florida has one of the highest biodiversity's of reef-associated fish species in the United States. Reef systems play a crucial role in sustaining regional biodiversity. Ongoing declines in natural coral reef systems caused by climate change, coastal development, and other anthropogenic factors have increased the reliance on artificial reefs as alternative structures for coral and fish communities to aggregate. Artificial reefs play an important role in maintaining marine biodiversity and provide habitat for reef-associated fishes. The Erojacks Reef, an artificial reef system located off the coast of Dania Beach, South Florida acts as a gathering site for reef fishes. …

A Review Of Reproductive Cycling In Batoid Dentition Morphology With New Data On Two Dasyatid Stingrays From The Western North Atlantic, Lacey Adamik

Undergraduate Student Symposium

Elasmobranchs continuously replace their teeth throughout their lifespan, allowing changes in tooth morphology associated with feeding and reproduction to occur. In many batoid species, males will bite females during pre-copulatory behavior, placing male dentition under selective pressure to meet the demands of both diet and grasping of females. Previous research has documented sexual dimorphism and seasonal dentition changes in several species of batoids, suggesting that this phenomenon is widespread. Much of this research is observation-based, and quantitative studies of dentition are limited, particularly in pelagic species. Pelagic Stingray (Pteroplatytrygon violacea) specimens were previously collected by commercial fishermen, and …

Modeling The Extracellular Matrix-Like Retinal Protein Pikachurin And Its Binding To Α-Dystroglycan And Gpcr (Gpr179), Mohit Belur, Khushi Raval, Riya Chelagiri, Rani Mehta

Undergraduate Student Symposium

Pikachurin is an extracellular matrix scaffold protein that links photoreceptor and ON-bipolar cell synapses by bridging the presynaptic dystroglycan complex and the postsynaptic receptor GPR179, ensuring precise synaptic alignment required for vision. Although its role in dystroglycanopathy associated visual phenotypes is well recognized, there is no published structural model showing how pikachurin engages α-dystroglycan or how this may influence GPCR linked synaptic signaling. This study computationally modeled full length Pikachurin using the complete nucleic acid sequence and available Protein Data Bank structures, integrating Jmol, AlphaFold, and literature-based analysis to predict domain organization, Ca²⁺-binding motifs, and glycan interaction sites …

The Role Of Hip Internal Rotation And Ground Reaction Forces On Lower Back Pain In Amateur Golfers, Katrina Arndt

Undergraduate Student Symposium

Lower back pain (LBP) is the most common musculoskeletal injury amongst golfers; the high velocity and repetitive motion of the golf swing on the lumbar spine leads to substantial compressive and torsional forces, making LBP primarily and overuse injury. An additional risk factor for LBP is limited lead hip internal rotation (LHIR), which forces the lumbar spine to compensate through excessive rotation. The golf swing also relies heavily on the efficient transfer of energy generated from the ground through the lower body, a process quantified by ground reaction forces (GRFs). While existing research has separately examined LBP and GRFs, there …

Disease-Modifying Therapies Targeting Neuroinflammation In Alzheimer's Disease: Evaluation Of Ongoing Clinical Trials, Shree Diora, Reagan Colavita, Christa Torchia

Undergraduate Student Symposium

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and behavioral changes. While traditionally associated with amyloid-β plaques and tau tangles, growing evidence implicates neuroinflammation as a key driver of disease progression. Microglial, astrocytic, and mast cell activation, along with elevated pro-inflammatory mediators, contribute to synaptic dysfunction and neuronal loss. Targeting these pathways offers promising therapeutic avenues beyond amyloid and tau-centric strategies. This study evaluates the emerging disease-modifying therapies in clinical trials that target neuroinflammation in AD, focusing on mechanisms, trial phases, and emerging clinical findings. The clinical trial website was accessed to find drug therapies under …

Transcranial Magnetic Stimulation For Substance Use Disorder, Sarah Defrant

Undergraduate Student Symposium

This review evaluates transcranial magnetic stimulation (TMS) as a supplemental intervention for decreasing substance use disorder (SUD) relapse rates by synthesizing understandings of neurobiological mechanisms and clinical outcomes. TMS stimulates the activity of neural cells in the dorsolateral prefrontal cortex (DLPFC), a small portion of the prefrontal cortex that houses impulse control and decision-making skills. This leads to improved neuroplasticity and dopamine regulation, both of which are disrupted by unregulated substance use. Although TMS is not FDA-approved for substance use disorder, the neurobiological similarities between SUD and its comorbidities like major depressive disorder or anxiety highlight TMS's theoretical potential to …

Bone Mineral Density, Mechanical Loading, And Mediterranean Diet Adherence In University Runners: A Pilot Study, Sathvi Gandra, Kiana Medina, Auston Hsieh

Undergraduate Student Symposium

Bone mineral density (BMD) is influenced by both mechanical loading and dietary patterns and is a determinant of skeletal health in distance runners. This exploratory study examined descriptive relationships among Mediterranean diet adherence, running biomechanics, and BMD in a pilot sample of competitive distance runners. Seven university runners, (18-21 years; 5 female, 2 male) completed dual-energy X-ray absorptiometry to assess total and segmental BMD, and a running biomechanical analysis on an instrumented treadmill. Biomechanical variables included peak vertical ground reaction force (vGRF), hip and knee joint reaction forces (JRF), ground contact time (GCT), and vertical stiffness(kvert). Dietary patterns …

Temperature-Driven Changes In Lysis Kinetics Of Bacteriophages Infecting Gordonia Rubripertincta, Bianca Gonzalez, Jyothi Vivekananda

Undergraduate Student Symposium

Antibiotic resistance represents a significant global health crisis creating a necessity for alternative treatments to combat drug-resistant pathogens. One alternative treatment is bacteriophages, such as those targeting Gordonia rubripertincta, a gram-positive, aerobic actinomycete bacterium which has shown intrinsic resistance to some antibiotics. Furthermore, G. rubripertincta can cause endocarditis and CNS infections in immunocompromised individuals. Phages that successfully target G. rubripertincta (Alyssamiracle, Fribs8, Genamy16, and NovaSharks) have been discovered by NSU students. The phages work in a lytic manner, bursting the bacteria and releasing its viral progeny. The goal of this research was to evaluate the lysis kinetics of these …

Epigenetic Upregulation Of P21 Via Mdm2 And Dnmt Inhibition Induces Cell Death In Neuroblastoma Cells, Helen Le, Sruthika Talanki, Shyam Jaganathan, Umamaheswari Natarajan

Undergraduate Student Symposium

Neuroblastoma is a childhood cancer that primarily impacts children, mostly under five years of age, that originates from neuroblast cells. It's located in the adrenal glands, neck, or thorax. Experimental evidence indicates that epigenetic modifications influencing cell cycle arrest and programmed cell death (PCD), including apoptosis, may provide an effective treatment strategy for enhancing neuroblastoma that is resistant to conventional therapies. This study explored MDM2 and DNMT pathways that might suppress DNA methylation leading to the upregulation of TET enzymes and p21, which trigger cell cycle arrest and apoptotic in IMR-32 cells were treated with RG-7388, CM-272, and SGI-1027 for …

Does A Competitive Season Alter Elastic Bounce Mechanics In University Distance Runners?, Marcus Marek Tortorella

Undergraduate Student Symposium

The spring-mass model (SMM) describes the body's center of mass oscillation during running as a bouncing system, where energy is absorbed and released, producing two asymmetries that represent muscle-tendon elastic function: (1) landing-takeoff (LTO; % relative difference propulsion to braking time), and (2) rebound (REB; % relative difference effective aerial to contact time). Additional SMM-derived variables, such as vertical stiffness(kvert) and step frequency (SF) may provide insight into the influence of a competitive season on running elastic bounce mechanics in university distance runners. The purpose of this study was to examine the impact of a competitive cross-country season …

Genetic Diversity Of Invasive Grey-Headed Swamphens In Florida Compared To Native Gallinules, Monica Maurer

Undergraduate Student Symposium

Invasive species outcompete native ones and threaten ecosystem stability. The grey-headed swamphen (Porphyrio poliocephalus), established in southeast Florida since 1996, continues to expand into the northern Everglades and Lake Okeechobee despite prior eradication attempts. This study is comparing the genetic diversity of invasive grey-headed swamphens to the genetic diversity of native purple (P. martinica) and common (Gallinula galeata) gallinules to better understand invasion history, competitive potential, and ecosystem impacts. Muscle tissue samples of P. porphyrio collected by the Florida Museum of Natural History from 1999-2023 and the Florida Fish and Wildlife Conservation Commission (FWC) …

Implementing Video Analysis And Titleist Performance Institute Level 1 Screening To Assess Sway In Collegiate Golfers, Sydney Mazur

Undergraduate Student Symposium

Golf swing mechanics are fundamental for proper performance and sustainability in the sport. Understanding the complexities of the golf swing as well are crucial in proper performance and prevent injury. Sway is a common swing fault that occurs in golfers because of improper swing fundamental mechanics. The Titleist Performance Institute (TPI) Level 1 screen is used in conjunction with video analyses to better understand swing mechanics. The purpose of this study is to better understand these specific components of the golf swing mechanics to prevent injury and improve performance for collegiate golfers. A total of 16 National Collegiate Athletic Association …

What Genograms Can Tell Us About Family Dynamics That Quantitative Data Cannot, Connor Mccarville, Jessica Frye, Maegan Mcdonough

Undergraduate Student Symposium

Genograms are an important clinical tool that is used to visually represent family relationships and their dynamics, but their effectiveness in empirical research remains limited. This mix-methods study examined the alignment between qualitative genogram visualizations and quantitative assessments of family dysfunctionality among individuals who exhibited high levels of risky sexual behavior. Based on preliminary data, currently with seven individuals with a high level of risky sexual behavior, we created genograms through interviews with young adult participants who described the emotional quality of each family relationship. Quantitative data on risky sexual behavior and whole family functioning were collected using the Family …

Time-Lapse Microscopy To Characterize Astrocyte Precursor Cells Migration Using A Double Reporter Mouse Line, Megan Hilliard, Sravika Chirla, Maria Ramirez

Undergraduate Student Symposium

Astrocytes, the most abundant non-neuronal cell type in the brain, are a diverse population of cells that play a central role in regulating synaptic activity, supporting neuronal energy demands, and modulating interactions among neurons, glia, and blood vessels. Astrocytes originate from astrocyte precursor cells (APCs) in the subventricular zone, from where they migrate to the cortex postnatally. Once in the cortex, APCs continue to proliferate and then undergo morphological and functional maturation. Using a double reporter mouse line engineered to express enhanced green fluorescent protein (eGFP) under the control of the entire glutamate transporter 1 (GLT1) gene and tdTomato (tdT) …

Dft Modeling Of Steroid–Phospholipid Noncovalent Interactions: Conformations, Binding Energy, And Solvation Effects, Sohan Mothkur

Undergraduate Student Symposium

Steroids (STRs) have essential roles in human physiology and disease, regulating processes such as metabolism and immunity. STRs exert their effects through receptor-mediated pathways and by modulating cell membrane properties. STRs can intercalate into phospholipid (PL) bilayers, altering membrane properties that can influence downstream biological processes. While STR-protein interactions have been widely studied, little is known about how STR-PL interactions influence membrane properties. In this study, we used density functional theory (DFT) to investigate the interactions between testosterone (TST) and cholesterol (CHOL) with three representative PLs: phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylglycerol (PG). STR-PL complexes were modeled using an aqueous …

Comparative Genomics Across Ganoderma Species To Identify Secondary Metabolite Clusters With Cytotoxic Properties, Fatima Muhammad, Maya Pasapuleti, Emily Abraham, Navya Mysore

Undergraduate Student Symposium

Fungi in the genus Ganoderma have been widely studied in Chinese culture for their medicinal properties and promoting overall health and longevity. Our prior work on eight Ganoderma species showed that they contain Secondary Metabolite Clusters (SMCs) that code for multiple terpenes, betalactones, and ribosomally synthesized and post-translationally modified peptides (RiPPs). These compounds are well known for their cytotoxic and anticancer potential. Using the bioinformatics platform antiSMASH, we previously identified and annotated the specific SMCs within these genomes that are predicted to produce such bioactive metabolites. To test the results obtained from the bioinformatics analysis, fungal extracts were prepared from …

Is Left Ventricular Dysfunction Associated With Increased Risk Of Alzheimer's Disease Independent Of Classical Vascular Dementia Pathways?, Priyanshi Patel

Undergraduate Student Symposium

This poster examines the potential connection between left ventricular dysfunction and the risk of Alzheimer's disease in older adults. Studies suggest that reduced heart function may affect brain health by limiting blood flow to the brain, increasing inflammation, and interfering with the brain's ability to clear harmful proteins such as amyloid-β and tau. These processes resemble changes commonly seen in Alzheimer's disease. In population-based studies, individuals with heart failure or structural abnormalities of the left ventricle appear to have a higher risk of developing dementia, including Alzheimer's disease, even after accounting for major risk factors such as hypertension and clinical …

Comparison Of Bacteria From Varied Soils With Potential Antimicrobial Activity, Nicole Nesterovitch, Nyobi Fleming, Andrew Sourial

Undergraduate Student Symposium

Antibiotic resistance is increasing at a rate that surpasses the discovery and development of new antimicrobial compounds, creating a widening resistance-innovation gap that poses a global public health concern. To address this need for new antibiotic-producing organisms, we partnered with Tiny Earth, a global initiative that engages students in antibiotic discovery through soil sample collection, bacterial isolation, and antimicrobial screening. We isolated bacteria from local soil in Davie, Florida as well as soil from the White River Badlands, South Dakota with the hypothesis that distinct soil conditions may yield different antimicrobial producers with varied activity and chemical profiles. 42 unique …

Analysis Of Conserved Domains In Promoters Of Differentially Expressed Genes In Rice, Mahalaxmi Some, Eimaan Ahmad, Emalynn Tobias

Undergraduate Student Symposium

Plant responses to stress involve changes in gene expression, and understanding these changes is key to improving crop resilience. A critical step in this process is identifying "conserved domains" in the promoters of Differentially Expressed Genes (DEGs), as these domains often provide binding sites for transcription factors. In this study, we aim to identify the Cis-Regulatory Elements (CREs) in the promoters of DEGs associated with heat stress. Previously, we identified 149 DEGs from transcriptomic analyses of two rice varieties, Cypress (heat-tolerant) and LaGrue (heat-sensitive), both exposed to high night temperatures (HNT; 82.4 ± 1°F or 28 ± 1°C). We hypothesize …

From Resume To Risk Factor: The Connections Between Occupation, Chronic Disease, And Mental Health In The United States, Nemo Thomas, Joshua Dumond, Nicole Real

Undergraduate Student Symposium

Mental health affects various aspects of overall health, including physical, emotional, and social well-being, which influences behavior and management of disease. Furthermore, occupational types (blue-collar, white-collar, and grey-collar) can influence how individuals manage stress. This can be due to the various responsibilities an individual has or the work environment that one is consistently exposed to, which can lead to detrimental mental health outcomes. This study examined the relationship between occupational type and the occurrence of individuals' self-reported levels of distress, anxiety, hopelessness, restlessness, sadness, and worthlessness. The data from this study was obtained from the IPUMS NHIS 2024 surveys, a …

Refining Potent Stat3 Inhibitor Structure Through Molecular Docking, Dev Patel, Dev Patel

Undergraduate Student Symposium

Signal Transducer and Activator of Transcription 3 (STAT3) plays a central role in signaling regulation in many cancers including glioblastoma. Normally, STAT3 is activated by the presence of ligand. In cancer cells, STAT3 is constitutively activated, making it a therapeutic target. STAT3 inhibitors currently used in clinical trials act by targeting upstream activators of STAT3. However, cancer cells bypass these pathways, activating STAT3 through receptor-pathway independent mechanism. Therefore, there is a need for inhibitors to directly target and inhibit STAT3, therefore blocking its function. Nitro groups (-NO₂) are being investigated as potential anti-cancer compounds. In cellular studies, IX-11 …

Biomechanical Stress And Asymmetrical Loading: Comparing Unilateral Landings Across Volleyball Hitter Positions, Nihar Patel

Undergraduate Student Symposium

Jump-based movements in volleyball, particularly unilateral landings, generate substantial injury risk to the anterior cruciate ligament (ACL). These landings create asymmetrical ground reaction forces and patellar joint instability, with outside and right-side hitters most affected since they often land on a single leg after spiking. Prior studies show that unilateral landings produce higher peak forces and reduced knee flexion compared to bilateral landings, increasing biomechanical stress. Lead-limb dominance and player position further influence landing mechanics and loading patterns. Using VERT, a wearable sensor that records jump height, frequency, and landing impact, along with synchronized video analysis, this study compares landing …

Colon Cancer Findings And A Community Solution, Brintia Wright

Undergraduate Student Symposium

Colorectal cancer remains a significant public health concern due to its high incidence, mortality, and persistent demographic disparities. The primary goal of this project was to develop an evidence-based community resource guide for the South Florida region to support early detection and equitable screening for colon cancer. The resource guide was informed by a structured review of current screening guidelines, peer-reviewed literature, and population-level data from the Surveillance, Epidemiology, and End Results (SEER) program. SEER incidence, stage at diagnosis, and survival data for individuals aged 25-84 years diagnosed with colon cancer between 2000 and 2022 were synthesized to identify high-risk …

Effects Of Renin-Angiotensin System Targeting Drugs On Cerebral Amyloid Angiopathy And Related Neuropathology, Anna Maria Weber, Ariana Hernandez, Chana Vogel, Victoria Pulido-Correa, Maria Agustina Paiz, Shaina Binu, Sonakshi Kose, Aayush Doshi, Dylan Kuni, Sylvia Yousef

Undergraduate Student Symposium

Cerebral amyloid angiopathy (CAA) is a common cerebrovascular disease characterized by beta-amyloid (Aβ) accumulation in the cerebral vasculature, resulting in vascular cognitive impairment and dementia (VCID) along with other neuropathologies such as inflammation. Given that medications approved to treat CAA currently do not exist, this highlights that there is a pressing need for more innovative approaches to drug discovery. In this study, classical renin-angiotensin system (RAS)-inhibiting antihypertensive drugs were repurposed to investigate their efficacy for mitigating CAA-associated neuropathology and cognitive decline, while additionally evaluating for sex-specific outcomes. Male and female Tg-SwDI mice were treated for 4 months with non-hypotensive doses …

Evaluting Practical Limitations Of Signal Detection Theory In Clinical Behavioral Research, Xinlei Zhang, Prarthana Harikrishnan

Undergraduate Student Symposium

Deficits in inhibitory control - the ability to suppress automatic, impulsive responses - has been widely considered as a potential biomarker for mental health disorders. Signal Detection Theory (SDT) has provided a systematic measurement method for inhibitory control in clinical behavioral assessment. To evaluate the feasibility of inhibitory control as a biomarker, researchers have used meta-analysis to examine its effect size (Hedge's g) in differentiating between individuals with mental health disorders and healthy controls. Values of g>0.8 indicate that inhibitory control may serve as a clinically useful biomarker for distinguishing patients from healthy individuals, whereas g<0.8 suggests limited clinical utility. However, our study found that a limitation of SDT - its lack of reliability when participants show perfect performance - would lead to distorted and misleading results when evaluating the efficacy of inhibitory control as a biomarker. In our computational simulation, we found that when applying SDT to a clinically useful biomarker (for example, true effect size g = …

Adapting The Alternative Program At Panther Community High School To Meet The Needs Of Its Students, Citlali J. Flores Hernandez

Dissertations

This study presents a comprehensive program evaluation of the PAGD alternative education program (a pseudonym) at Panther Community High School, a program that had not undergone formal revision since approximately 2015. The purpose of the study was to examine the effectiveness of the PAGD program in addressing students’ academic, behavioral, and social-emotional needs, and to identify areas in need of improvement to support both student success and long-term program sustainability. The evaluation was guided by four primary research questions: To what extent is the PAGD program meeting students’ needs? To what extent are PAGD program teachers receiving the necessary support? …

Factors Associated With Child Protective Services Referrals In Young Children With Isolated Skull Fractures., Karli Breeden-Carino, Joanne N. Wood, Cindy W. Christian, Tagrid M. Ruiz-Maldonado, Daniel M. Lindberg, Angela Bachim, Lori Frasier, Terra N. Frazier, Nancy S. Harper, Sara E. Kruczek, Farah Brink, Jennifer E. Wolford, Jan Leonard, M Katherine Henry

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Many young children with isolated skull fractures are referred to child protective services (CPS) despite being assessed to have a low likelihood of abuse. We sought to identify factors associated with CPS referrals in this population and to quantify hospital-level variation.

METHODS: We performed a multicenter retrospective cross-sectional study of children < 2 years with skull fractures with or without a small underlying intracranial hemorrhage (ICH) and no additional injuries undergoing a child abuse pediatrics (CAP) subspecialty evaluation. We explored associations between demographic factors, clinical characteristics, psychosocial risk factors, and hospital site with CPS referral status. We performed multivariable logistic regression, adjusting for transfer status and all significant covariates from unadjusted analyses. We utilized marginal standardization to calculate the estimated probability of CPS referrals at each site, adjusting for all factors in the final model.

RESULTS: Of 528 children, 303 (57.4%) were referred to CPS, with 86.5% referred before CAP consultation. In multivariable logistic regression, presence of psychosocial risk factors (OR 4.00; 95% CI 2.25, 7.11), in-person CAP consult (OR 3.93; 1.61, 9.62), inflicted or no trauma history provided (OR 6.15; 3.30, 11.45), …

Caregiver Challenges And Health Access For Individuals With Developmental Disabilities In Mississippi, Kirsten Cunningham

Honors Theses

Current literature has highlighted the health disparities faced by individuals within the disability community and how it affects the care they receive. However, for many individuals with developmental disabilities, they require caregivers to make medical decisions for them. The purpose of this study is to focus on the caregiver’s perspective of caregiver stress, physical access to care, and health literacy to combat the challenges faced when getting access to healthcare resources for individuals with developmental disabilities in Mississippi. The researcher hypothesized, based on the literature review, that caregivers with higher levels of educational attainment would have less caregiver stress, more …

Physical And Behavioral Health Diagnoses And Comorbidities Associated With Transition From Military Health System To Veterans Health Care Among Post-9/11 Veterans, Nikki R. Wooten, Megan E. Amaun, Madeleine Myers, Price N.O. Addo, Jeffrey Bowers, Felicia R. Carey, Rudolph P. Rull, Edward J. Boyko, Nathaniel Bell Ph.D., Ana Defede-Lopéz, Mary Jo V. Pugh

Publications

Objective

To identify factors associated with transitioning from Military Health System (MHS) to Veterans Health Administration (VHA) care in post-9/11 veterans.

Study Setting and Design

Retrospective cohort study from the Long-Term Impact of Military-Relevant Brain Injury Consortium Phenotype Study.

Data Sources and Analytic Sample

Population-level data were analyzed from MHS and VHA electronic health data (FY2000-2020). Participants received ≥ 3 years of MHS care and separated from the military before October 1, 2016. The primary outcome was transition from MHS to VHA care after military separation. Covariates included demographic, military, and deployment characteristics at military separation; physical, mental, and substance …

The Roddey Mcmillan Record - April 2026, Winthrop University

The RMR 2020-2029

The Roddey McMillan Record (RMR) is Winthrop’s monthly multicultural student publication. The RMR has been a significant voice of the minority population of the Winthrop community since its creation by Gail Harris in April 1986. It promotes awareness and understanding of issues concerning minorities for the prosperity of the entire Winthrop community. The purpose of the RMR is to shine light on the many diverse cultures at Winthrop, focusing on issues, concerns and happenings of those who represent the multicultural community on campus. The Roddey McMillan Record is named after Dr. Cynthia Roddey and Atty, Sheila McMillan. Cynthia Roddey was …