Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (5125)
- Arts and Humanities (3856)
- Education (2721)
- Medicine and Health Sciences (2566)
- Law (2533)
-
- Physical Sciences and Mathematics (1458)
- Business (1364)
- Life Sciences (1211)
- Psychology (1070)
- Engineering (946)
- Art and Design (943)
- Sociology (909)
- Communication (868)
- Higher Education (683)
- Political Science (649)
- Public Affairs, Public Policy and Public Administration (627)
- History (599)
- Medical Sciences (535)
- Computer Sciences (528)
- Film and Media Studies (508)
- Public Health (476)
- Feminist, Gender, and Sexuality Studies (455)
- Medical Specialties (430)
- Religion (427)
- Constitutional Law (400)
- Teacher Education and Professional Development (383)
- Marketing (379)
- Economics (374)
- Curriculum and Instruction (371)
- Library and Information Science (368)
- Institution
-
- University of Texas at Arlington (953)
- Universitas Indonesia (692)
- Liberty University (594)
- Universitas Negeri Malang (497)
- Technical Disclosure Commons (489)
-
- TÜBİTAK (479)
- Walden University (476)
- Design Research Society (405)
- Arkansas State University (384)
- Brigham Young University (341)
- University of Montana (326)
- California Polytechnic State University, San Luis Obispo (312)
- City University of New York (CUNY) (304)
- Kennesaw State University (286)
- University of Central Florida (286)
- The Texas Medical Center Library (276)
- American Dental Association (273)
- Georgia Southern University (255)
- Edith Cowan University (252)
- Clemson University (243)
- Duquesne University (237)
- San Jose State University (224)
- University of Arkansas, Fayetteville (218)
- University of Kentucky (216)
- University of Technology (209)
- University of Mississippi (207)
- University of New Hampshire (207)
- University of South Florida (204)
- Universitas Padjadjaran (200)
- Old Dominion University (198)
- Keyword
-
- Humans (298)
- Artificial intelligence (248)
- Social media (210)
- Female (174)
- Education (168)
-
- Mental health (150)
- Artificial Intelligence (149)
- AI (140)
- Male (138)
- Higher education (136)
- Virginia Dental Association (121)
- Animals (118)
- Gender (107)
- Generative AI (100)
- Communication (99)
- Mice (93)
- Newsletter (93)
- Social Media (92)
- Engineering (90)
- Identity (90)
- Hospital newsletter (86)
- ASMC (84)
- Employee newsletter (84)
- Leadership (84)
- Sustainability (82)
- Technology (77)
- Adult (75)
- United States (74)
- COVID-19 (73)
- History (73)
- Publication
-
- Theses and Dissertations (638)
- The Shorthorn Newspaper Collection: 1980s (496)
- Defensive Publications Series (489)
- Walden Dissertations and Doctoral Studies (431)
- Doctoral Dissertations and Projects (413)
-
- DRS Biennial Conference Series (387)
- All Approved Curriculum (342)
- Fast Capitalism (328)
- Jurnal Hukum & Pembangunan (263)
- Honors Theses (253)
- Jurnal Pendidikan Humaniora (235)
- Research outputs 2022 to 2026 (229)
- Engineering and Technology Journal (209)
- Creative Nonfiction Magazine (198)
- Masters Theses (180)
- Theses & ETDs (177)
- University of Montana Course Syllabi, 2026-2030 (172)
- Electronic Theses and Dissertations (148)
- Theses (148)
- Virginia Dental Journal (147)
- Jurnal Ilmu Ternak Universitas Padjadjaran (144)
- Dissertations (142)
- Turkish Journal of Medical Sciences (138)
- Atlantic Marketing Association Proceedings (133)
- Historical Documents - Combined (126)
- Fresh Voices: Composition at Cal Poly (124)
- Faculty, Staff and Student Publications (120)
- Faculty Scholarship (117)
- Faculty, Staff and Students Publications (114)
- Silver Bow Creek/Butte Area Superfund Site (113)
- Publication Type
Articles 24751 - 24780 of 25716
Full-Text Articles in Entire DC Network
Standards For Leadership In Oral Health Care. A Project Of The Board Of Regents Of The American College Of Dentists, Robert A. Faiella Dmd, Mmsc., Mba, Teresa A. Dolan Dds, Mph, Facd, N. Karl Haden Phd, Facd, Sreenivas Koka Dds, Ms, Phd, Mba, Mas, Facd, Sir Nairn H.F. Wilson Cbe Dsc(H.C.) Ddent(H.C.) Phd Msc Bds Fcgdent Fds Rcs Edin, Eng(Hon) & Rcps Glasg(Hon) Ffd Rcsi(Hon) Fcdshk(Hon) Fracds(Hon) Drd Fhea Facd Ficd Fadm Fpfa Frsm Fkc
Standards For Leadership In Oral Health Care. A Project Of The Board Of Regents Of The American College Of Dentists, Robert A. Faiella Dmd, Mmsc., Mba, Teresa A. Dolan Dds, Mph, Facd, N. Karl Haden Phd, Facd, Sreenivas Koka Dds, Ms, Phd, Mba, Mas, Facd, Sir Nairn H.F. Wilson Cbe Dsc(H.C.) Ddent(H.C.) Phd Msc Bds Fcgdent Fds Rcs Edin, Eng(Hon) & Rcps Glasg(Hon) Ffd Rcsi(Hon) Fcdshk(Hon) Fracds(Hon) Drd Fhea Facd Ficd Fadm Fpfa Frsm Fkc
Journal of the American College of Dentists
This section of the Journal of the American College of Dentists presents professional conference proceedings and/or published guidelines relevant to dentistry, ethics, education, leadership, policy, or clinical care. Conference proceedings may also include documents from affiliate organizations in dentistry.
Empathy And Human-Centered Leadership In Community Health Center Dental Clinics, Pamela S. Alston Dds, Mpp, Facd
Empathy And Human-Centered Leadership In Community Health Center Dental Clinics, Pamela S. Alston Dds, Mpp, Facd
Journal of the American College of Dentists
A person-centered approach, with empathy toward patients, can improve satisfaction among both patients and dental health professionals. A dental director with a human-centered leadership style can improve the well-being of oral health team members. This article describes the role that empathy, a core value of humanism and professionalism, plays in accomplishing these improvements in community health center dental clinics. This article also describes the risks of empathy, as experienced by the author in her role as a dental director and practitioner, as well as documented in the literature. It further focuses on dental directors’ human-centered approaches to supporting oral health …
The Personal, Professional, And Practice: Integrating Health Humanities Into Dental Education, Margie Hodges Shaw Jd, Ma, Phd, Michael Yunker Dds, Nicholas Mercado Drph, Ms
The Personal, Professional, And Practice: Integrating Health Humanities Into Dental Education, Margie Hodges Shaw Jd, Ma, Phd, Michael Yunker Dds, Nicholas Mercado Drph, Ms
Journal of the American College of Dentists
Dentistry’s evolution as a profession reflects both scientific progress and enduring tensions between commercial and service-oriented models of care. Despite long-standing commitments to ethical education, dental training continues to privilege technical mastery over professional identity formation, leaving some future practitioners underprepared for the ethical and relational complexities of clinical practice. This paper situates these challenges within the historical separation of dentistry and medicine and argues that integrating the health humanities into dental education can strengthen professional identity formation and clinical ethics competency. Using a case study, we demonstrate how biases, professional obligations, and patient trust intersect in practice. We introduce …
Building A Cell Specific System For In Vivo Rna Imaging Of The Endogenous Actin Gene In C. Elegans, Jasmine A. Huerta Canete
Building A Cell Specific System For In Vivo Rna Imaging Of The Endogenous Actin Gene In C. Elegans, Jasmine A. Huerta Canete
Theses and Dissertations
Messenger RNA (mRNA) plays a crucial role in protein synthesis and cellular processes, important for the development of cells such as neurons. When dysregulation occurs, it can lead to outcomes such as aberrant translation, causing neurodegenerative conditions to arise. Unfortunately, the localization of mRNA in an in vivo cell specific manner is still not understood. To address this, we decided to develop a cell-specific system to image RNA in vivo, within the organism known as C. elegans with a focus on the actin gene. The Actin gene encodes for an important cytoskeleton protein expressed ubiquitously, vital for the cell …
The Persistent Shock Of The Old: Making The Case For The Responsive Development Of Artwork Deploying Historical Museological Display Techniques., Duncan Cameron
The Persistent Shock Of The Old: Making The Case For The Responsive Development Of Artwork Deploying Historical Museological Display Techniques., Duncan Cameron
School of Art, Design and Architecture Theses
My sculpture work and thesis investigate the potential of historical museological practices—particularly Victorian and Edwardian display technologies—in contemporary art-making and sculptural practice. I ask three central questions: how can the collection and display of natural history materials be ethically defended in the present day; how might traditional exhibition orthodoxies be reconfigured to privilege the prosaic, domestic, and handmade over the novel and precious; and what role does the idiosyncratic and beautiful play in narrating material stories within an ethical, Anthropocene-aware framework?The study employs a practice-led methodology combining iterative art-making, critical reflection, and active fieldwork. Working from a studio in Somerset, …
All Life As Witness: Developing A Mode Of Investigation Into Political Disappearance In 1960s Venezuela Reframed By Skinner Releasing Technique And Indigenous Knowledge, Livia Daza-Paris
School of Art, Design and Architecture Theses
This practice-based research develops Ecologies of Poetic Forensics, an investigative mode for approaching political disappearance as a felt, ongoing condition that also reverberates across worlds beyond the human. Focused on my father's disappearance during Venezuela's 1960s revolutionary movement, the research follows relational dynamics within the personal, political, ecological ‘many worlds’ (Indígena Zapatistas 1996) shaped by state violence, including those of campesinos (land-based workers) in Cocorote, Lara State. The inquiry unfolds across Venezuela, Canada, and the United States, tracing territory that exceeds state borders.
The research brings the Skinner Releasing Technique, a movement practice oriented by poetic imagery and embodied …
A Balm For The Broken: Bearing The Scars And Songs Of Generational Survival In A World That Denies Our Humanity, Desmond Beach
A Balm For The Broken: Bearing The Scars And Songs Of Generational Survival In A World That Denies Our Humanity, Desmond Beach
School of Art, Design and Architecture Theses
“We survived to tell the tale.” This dissertation explores the intersections of visual art, Black cultural memory, and spiritual labor through a body of creative and scholarly work rooted in Black textile traditions. Informed by the artist’s upbringing in West Baltimore and shaped by the spiritual and communal practices of the Black church, the research considers artmaking as a form of ritual, resistance, and remembrance. Patchwork, performance, and mixed media installations become not only expressive gestures but also repositories of intergenerational memory, sites of ancestral presence, and acts of survival that exceed mere endurance.The dissertation integrates creative production with critical …
Planetarity And Relation: Ecology As Method, Ashish Ghadiali
Planetarity And Relation: Ecology As Method, Ashish Ghadiali
School of Art, Design and Architecture Theses
The List of Works submitted comprises research through film, text, exhibition, performance and policy engagement, developed during a three-year period from 2021 to 2024 in the site-specific location of Southwest England. This multi-modal and interdisciplinary practice is framed in response to the question of how art and cultural strategy can, in the contexts of climate breakdown and global racial inequity, be conceived of as agency for environmental justice. In this integrative summary, I present a theoretical framework where ecology, in response to conditions of environmental crisis, is understood not only as a subject of inquiry but also as method. In …
The Influence Of Historical Technological Constraints On Contemporary Music Practice, Clive Mead
The Influence Of Historical Technological Constraints On Contemporary Music Practice, Clive Mead
School of Art, Design and Architecture Theses
This practice-based research project explores the creative implications of working within historically constrained music production environments. By composing and producing original music using only emulated instruments, effects, and recording technologies from four key eras—1955, 1965, 1975, and 1985—the study examines how technological limitations affect contemporary compositional practice. The project is situated at the intersection of music production, creative practice research, and is conducted by a composer-producer with extensive experience across diverse musical genres.The research addresses three central questions: What occurs when a proficient modern producer is restricted to using tools from earlier periods of recorded music history? In what ways …
Music And Mecha: An Analysis Of Mobile Suit Zeta Gundam, Jackson Grey Baker
Music And Mecha: An Analysis Of Mobile Suit Zeta Gundam, Jackson Grey Baker
Research Honors
Music within anime is a topic that has only recently gained traction in terms of academic study in the west. Consequently, there is not a particularly great body of literature yet. Much work has been done regarding the music that introduces the anime and accompanies the closing credits of the show, as these songs often become very popular, sometimes even outside of the anime sphere. But the soundtrack to the show itself is also very important. Within the show there is a large amount of music that connects to the plot, themes, characters, moods and more which greatly affect the …
“We Only Care For White Germs”: How Black Chicagoans Used Community Care To Overcome Medical Discrimination, Kylie Power
“We Only Care For White Germs”: How Black Chicagoans Used Community Care To Overcome Medical Discrimination, Kylie Power
Research Honors
This project examines the use of Community Care as a means of healthcare within Black American populations, specifically in Chicago. Background information is provided on the evolution of Community Care, from slavery, to post-emancipation, to the early 20th century. Provident Hospital of Chicago in particular is examined during the early 20th century section, with a look at how the 1918 Spanish Influenza affected the Hospital, it's patrons, and Chicago. Important pieces of literature from the time period are combined with newspaper articles and other reports, as well as secondary literature, to construct this social history.
Examining The Nexus Between Social Capital, Value Co-Creation And Entrepreneurship In Nigeria: Assessing The Moderating Role Of Social Media In A Resource-Constrained Context, Ben Omoruyi
Plymouth Business School Theses
This research provides a transformative perspective on how Social Capital (SC), Value Co creation (VCC), and Social Media (SM) interact to shape Entrepreneurial Outcomes (EOs) in institutionally weak, resource-constrained contexts. Positioned within a positivist ontology and grounded in Social Capital Theory, the research reconceptualises SC not as a passive stock of relationships but as a dynamic entrepreneurial capability, strategically mobilised to access resources, legitimacy, and opportunities. Focusing on Nigeria’s fashion industry, a sector characterised by informality, weak institutions, and heavy network reliance, the study adopts a quantitative, deductive design. Data from a cross-sectional survey of 580 entrepreneurs aged 18–55, in …
Driving Venture Success: A Collaborative Framework For The Consumer Goods Industry, Mohammad Alhusaeini Mohammad
Driving Venture Success: A Collaborative Framework For The Consumer Goods Industry, Mohammad Alhusaeini Mohammad
Plymouth Business School Theses
This thesis addresses the persistent gap between the strategic promise of external corporate venturing (ECV) and its frequently disappointing outcomes in the global consumer goods industry, with a specific focus on the non-durable consumer goods sub‑sector. Despite ECV’s recognised importance for innovation—particularly in a sector characterised by rapid consumer preference shifts, tight margins, and complex supply chains—collaborations with external start-ups are often undermined by cultural misalignment, strategic ambiguity, and ineffective performance measurement. Through an abductive, mixed-methods research design within an interpretivist paradigm—integrating archival analysis, six in-depth corporate case studies (P&G, PepsiCo, Unilever, Danone, Henkel, and L’Oréal), and 32 interviews with …
The Epidemiology Of Catastrophic Head And Neck Injuries In High School And College Non-Football Sports: A 4-Decade Review, Courtney M. Meyer, Kristen L. Kucera, Samantha E. Scarneo-Miller, Zachary K. Winkelmann, Susan W. Yeargin
The Epidemiology Of Catastrophic Head And Neck Injuries In High School And College Non-Football Sports: A 4-Decade Review, Courtney M. Meyer, Kristen L. Kucera, Samantha E. Scarneo-Miller, Zachary K. Winkelmann, Susan W. Yeargin
Rehabilitation Sciences Faculty Publications
Background:
Catastrophic head and neck injuries (CHNIs) in sport are rare but can have disabling or fatal outcomes. Prior studies have focused on football, equipment-laden sports, or different injury severities, not CHNI in nonfootball sports.
Purpose:
To describe the epidemiology of CHNI across levels (high school vs collegiate) in nonfootball sports and evaluate differences in injury rates (IRs) by sport, sex, and decade.
Study Design
Descriptive epidemiological study.
Methods:
This study utilized 40 academic years (1982-1983 to 2021-2022) of surveillance data from the National Center for Catastrophic Sports Injury Research. Descriptive statistics summarized athlete, event, and injury characteristics. IRs were …
Graduate Catalog 2026-2027, Southwestern Oklahoma State University
Graduate Catalog 2026-2027, Southwestern Oklahoma State University
Graduate Catalogs
No abstract provided.
Dampak Program Pembangkit Listrik 35.000 Mw Terhadap Tingkat Pekerjaan Dan Kemiskinan Di Indonesia, Yohanes Dwi Anggoro, Jahen Fachrul Rezki
Dampak Program Pembangkit Listrik 35.000 Mw Terhadap Tingkat Pekerjaan Dan Kemiskinan Di Indonesia, Yohanes Dwi Anggoro, Jahen Fachrul Rezki
Jurnal Ekonomi dan Pembangunan Indonesia
This research analyzes the 35,000 MW Program’s impact on employment and poverty levels in Indonesia using the Callaway and Sant’Anna Difference-in-Differences (CSDID) method. The research uses panel data at the district/city level from 2007 to 2022. The analysis shows the program has a significant impact on reducing poverty, with an average reduction of 5,208 poor people in Model 1; 4,277 people in Model 2; and 4,284 people in Model 3. Based on a subset of regions, the analysis shows the program had a significant impact on increasing the employment rate by 1.2 percent, reducing 16,034 poor people in the Java-Madura-Bali.
Inside, Outside, And In Between: Black Homeplace As A Blueprint For Privacy Law, Nina-Simone Edwards
Inside, Outside, And In Between: Black Homeplace As A Blueprint For Privacy Law, Nina-Simone Edwards
Library Scholarship
This essay reimagines the meaning of home and privacy for Black Americans by interrogating the legal and technological systems that routinely collapse the sanctity of the homeplace. Using the no-knock warrant as a central case study, this essay illustrates how state-sanctioned intrusions transform a space of rest, memory, and self-making into a site of violence. Although Fourth Amendment doctrine purports to guard against unreasonable searches, its prevailing binary framework–distinguishing only between “inside” and “outside” the home–renders Black domestic spaces uniquely vulnerable. Drawing from Critical Race Theory, particularly its social construction thesis, this essay shows how race, law, and technology co-produce …
Timing Whistleblowing, Andrew K. Jennings
Timing Whistleblowing, Andrew K. Jennings
Faculty Articles
Whistleblower programs (WBPs) expose hidden corporate wrongdoing. They do so by offering retaliation protection and financial bounties to those who bring original information to law enforcement about unseen, and often complex, misconduct. Under a standard account, whistleblowing serves the public interest by increasing the ex post detection of illegal activity and the ex ante risk of its exposure. That standard view—which centers whistleblowing on detecting wrongdoing—is incomplete, however. To present a fuller view, this Article introduces a complementary model that refocuses whistleblowing as preventing wrongdoing. Working together, these models show that a WBP can do more than enable detection at …
Catholic Solidarity In American Jesuit Education Through The Radical Kinship Of Fr. Greg Boyle: A Conceptual Analysis, Sajit U. Kabadi
Catholic Solidarity In American Jesuit Education Through The Radical Kinship Of Fr. Greg Boyle: A Conceptual Analysis, Sajit U. Kabadi
Journal of Catholic Education
This is a conceptual analysis that examines how American Jesuit secondary education can pursue greater Catholic solidarity in a polarized world through a framework of radical kinship, as espoused by Fr. Greg Boyle. Boyle is the founder of Homeboy Industries, the world’s largest gang rehabilitation program, in the city of Los Angeles. The purpose of this conceptual analysis is to delve deeper into Boyle’s conceptual framework of radical kinship in the context of American Jesuit secondary education. This conceptual analysis will use Catholic Social Teaching, Biblical references, and the values of the Jesuit mission.
At The Crossroads Of Law And Society: Understanding The World Of Immigration Attorneys., Elvis Ariri
At The Crossroads Of Law And Society: Understanding The World Of Immigration Attorneys., Elvis Ariri
Senior Independent Study Theses
This independent study examines the professional experiences of immigration attorneys working with immigrant clients in the United States. Through qualitative, semi-structured interviews, the research explores how immigration law operates in practice, emphasizing systemic complexity, administrative delay, and discretionary decision-making. Findings reveal that attorneys navigate a fragmented legal framework shaped by shifting policies, inconsistent adjudication, and high emotional stakes. Beyond technical expertise, immigration practice requires emotional resilience, ethical judgment, and strategic adaptability. By centering attorneys’ perspectives, this study highlights immigration law as a lived social system that structures belonging, exclusion, and stability, illuminating the gap between statutory intent and human consequence.
A User-Friendly Graphical User Interface For Paw Touch Classification In Rodent Cylinder Testing, Tyler R Johnson, Katherine D Zerefos, Dawn M Taylor
A User-Friendly Graphical User Interface For Paw Touch Classification In Rodent Cylinder Testing, Tyler R Johnson, Katherine D Zerefos, Dawn M Taylor
Faculty, Staff and Student Publications
In unilateral rodent models of disease or injury, deficits are induced in only one side of the body, allowing the difference in right versus left limb usage to serve as a metric of disease/injury severity and recovery with various treatments. Unilateral rat models are commonly used for conditions such as Parkinson’s disease (via the neurotoxin 6-hydroxydopamine, 6-OHDA), stroke, and traumatic brain injury, as well as cervical spinal cord injury and peripheral nerve damage. The ‘cylinder test’ has been used for over two decades as a reliable metric of asymmetry in forelimb usage. In this test, videos are taken of the …
Enhancing Inter-Institutional Ai Research Collaboration Across Multidisciplinary Teams To Increase The National Ai Workforce In Healthcare, Toufeeq Ahmed Syed, Sarah Popal, D'Laney Kernan, Deevakar Rogith, Zulfiia Ditto, Paul Warhurst, Jay Johnson, Jamboor K Vishwanatha
Enhancing Inter-Institutional Ai Research Collaboration Across Multidisciplinary Teams To Increase The National Ai Workforce In Healthcare, Toufeeq Ahmed Syed, Sarah Popal, D'Laney Kernan, Deevakar Rogith, Zulfiia Ditto, Paul Warhurst, Jay Johnson, Jamboor K Vishwanatha
Faculty, Staff and Student Publications
Inter-institutional team collaboration is critical for impactful multidisciplinary AI research in healthcare. The goal of our project (AIM-AHEAD Connect) is to increase multidisciplinary collaborations by connecting AI/ML experts and healthcare researchers, trainees and professionals to enhance research and improve health for all Americans. As of February 2026, AIM-AHEAD Connect has over 10,100 AI/ML and healthcare experts from across 2,400 institutions, has made more than 7,800 connections and facilitated 194 collaborative online groups. We conducted a unique study to understand collaboration, and analyzed profile, connection, and platform engagement metrics to determine if AI experts and healthcare researchers with more inter-institutional connections …
Rewiring The Immune Response In Lung Cancer: Current Progress In Bispecific Antibodies, Car-T Therapy, And The Rise Of In Vivo Car-T Platforms, Lei He, Yi Sun, Bowen Ma, Guojun Lang, Jianguo Wen, George R Blumenschein, Hong Ma
Rewiring The Immune Response In Lung Cancer: Current Progress In Bispecific Antibodies, Car-T Therapy, And The Rise Of In Vivo Car-T Platforms, Lei He, Yi Sun, Bowen Ma, Guojun Lang, Jianguo Wen, George R Blumenschein, Hong Ma
Faculty, Staff and Student Publications
Lung cancer remains the leading cause of cancer mortality worldwide and continues to impose a major clinical burden, particularly in advanced non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). Although targeted therapies, antiangiogenic agents, immune checkpoint inhibitors, and antibody-drug conjugates have improved outcomes in selected patients, durable responses remain limited by primary and acquired resistance. Here, we comprehensively review recent progress in immunologically oriented therapeutic strategies for lung cancer, focusing on bispecific antibodies, chimeric antigen receptor (CAR) T-cell therapy, and emerging in vivo CAR-engineering modalities. We further elaborate on the clinical rationale, latest translational and early clinical evidence, …
Deep Learning To Predict Future Cognitive Decline: A Multimodal Approach Using Brain Mri And Clinical Data, Tamoghna Chattopadhyay, Pavithra Senthilkumar, Rahul H Ankarath, Christopher Patterson, Emma J Gleave, Sophia I Thomopoulos, Heng Huang, Li Shen, Lei You, Degui Zhi, Paul M Thompson
Deep Learning To Predict Future Cognitive Decline: A Multimodal Approach Using Brain Mri And Clinical Data, Tamoghna Chattopadhyay, Pavithra Senthilkumar, Rahul H Ankarath, Christopher Patterson, Emma J Gleave, Sophia I Thomopoulos, Heng Huang, Li Shen, Lei You, Degui Zhi, Paul M Thompson
Faculty, Staff and Student Publications
Predicting the trajectory of clinical decline in aging individuals is a pressing challenge, especially for people with mild cognitive impairment, Alzheimer's disease, Parkinson's disease, or vascular dementia. Accurate predictions can guide treatment decisions, identify risk factors, and optimize clinical trials. In this study, we compared two deep learning approaches for forecasting changes, over a 2-year interval, in the Clinical Dementia Rating scale 'sum of boxes' score (sobCDR), as a continuous outcome (regression). This is a key metric in dementia research and clinical trials, and scores range from 0 (no impairment) to 18 (severe impairment). To predict decline, we trained a …
Bop2-Comb: Bayesian Optimal Phase Ii Design For Optimizing Doses And Assessing Contribution Of Components In Drug Combinations, Xiaohan Chi, Ying Yuan, Ruitao Lin
Bop2-Comb: Bayesian Optimal Phase Ii Design For Optimizing Doses And Assessing Contribution Of Components In Drug Combinations, Xiaohan Chi, Ying Yuan, Ruitao Lin
Faculty, Staff and Student Publications
Background: Personalized cancer treatment using combination therapies offers substantial therapeutic benefits over single-agent treatments in most cancers. However, unmet clinical needs and increasing market competition pressure drug developers to quickly optimize combination doses and clearly demonstrate the contribution of each component when developing and evaluating new combination treatments.
Methods: We propose a Bayesian optimal phase II drug-combination (BOP2-Comb) design that optimizes the combination dose and evaluates the proof-of-concept as well as the contribution of each component in two seamless stages. Our optimal calibration scheme minimizes the total trial sample size while controlling incorrect decision rates at nominal levels. This calibration …
Mathematical Modeling Predicts Novel Mechanisms Of Stream Confinement From Trail/Colec12/Dan In The Collective Migration Of Cranial Neural Crest Cells., Samuel W S Johnson, Paul M. Kulesa, Ruth E. Baker, Philip K. Maini
Mathematical Modeling Predicts Novel Mechanisms Of Stream Confinement From Trail/Colec12/Dan In The Collective Migration Of Cranial Neural Crest Cells., Samuel W S Johnson, Paul M. Kulesa, Ruth E. Baker, Philip K. Maini
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: In vertebrate embryogenesis, cranial neural crest cells (CNCCs) migrate along discrete pathways. Analyses in the chick have identified key molecular candidates for the confinement of CNCC migration to stereotypical pathways as Colec12, Trail, and Dan. The effects of these factors on CNCCs in vitro are known, but how they confine migration to discrete streams in vivo remains poorly understood. Here, we propose and test several hypothetical mechanisms by which these factors confine cell streams and maintain coherent migration, simulating an expanded agent-based model for collective CNCC migration.
RESULTS: Model simulations suggest that Trail enhances adhesion between CNCCs, facilitating movement …
Freeze-Dried, Not Frozen: Lyophilized Mesenchymal Stromal Cell-Derived Extracellular Vesicles And Therapeutic Function In Neuroinflammatory Models, Janet R Ashley, Aidan M Collier, Scott D Olson, Charles S Cox
Freeze-Dried, Not Frozen: Lyophilized Mesenchymal Stromal Cell-Derived Extracellular Vesicles And Therapeutic Function In Neuroinflammatory Models, Janet R Ashley, Aidan M Collier, Scott D Olson, Charles S Cox
Faculty, Staff and Student Publications
Background: Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) offer a promising acellular therapy for immune modulation, but clinical translation is hindered by variability and storage constraints. Lyophilization (freeze-drying) could enable shelf-stable EV therapeutics, although its effects on biological activity remain incompletely defined.
Study design: We compared the immunomodulatory effects of frozen and lyophilized EVs from bone marrow (BM), adipose tissue (AD), and umbilical cord (UC) MSCs using lipopolysaccharide-stimulated rodent splenocytes and microglial models and human peripheral blood mononuclear cells (PBMCs). Variables included batch scale (small vs large), cytokine priming, and MSC source. Tumor necrosis factor alpha (TNF-α) secretion was measured …
Digital Communication Strategies For Culinary Medicine In Cancer Prevention And Survivorship: Information-Seeking Habits And Content Preferences Of Online Cooking Media Among Adults Participating In Four Cancer Prevention And Control Cohort Studies, Margaret Raber, Sara Fares, Maria Vazquez, Larkin Strong, Carrie Daniel-Macdougall, Lorna Mcneill, Karen Basen-Engquist
Digital Communication Strategies For Culinary Medicine In Cancer Prevention And Survivorship: Information-Seeking Habits And Content Preferences Of Online Cooking Media Among Adults Participating In Four Cancer Prevention And Control Cohort Studies, Margaret Raber, Sara Fares, Maria Vazquez, Larkin Strong, Carrie Daniel-Macdougall, Lorna Mcneill, Karen Basen-Engquist
Faculty, Staff and Student Publications
Introduction
Poor diet and excess weight have been linked to increased risk for at least 13 types of cancer. Culinary medicine utilizes experiential cooking skill development to improve individuals’ capacity for healthy eating. Digital communication strategies offer pathways for scalable culinary medicine interventions, but little research has explored how online cooking tools could be leveraged for cancer prevention messaging. We conducted a cross-sectional survey study exploring online cooking information-seeking habits and content preferences among participants in four cancer prevention and control cohorts to inform future digital culinary medicine interventions.
Methods
A cross-sectional survey study was conducted with a convenience sample …
Supporting Financial Well-Being Through Habits And Routines: An Occupational Therapy Online Toolkit For College Students, Diana Cadena
Supporting Financial Well-Being Through Habits And Routines: An Occupational Therapy Online Toolkit For College Students, Diana Cadena
OT Doctoral Capstones
Purpose: This doctoral capstone project aimed to support financial well-being among UTEP students by providing accessible, occupation-based resources to promote healthy financial habits and routines.
Methods: An occupational therapy-informed financial wellness toolkit, Miner Money Matters, was developed as a website for UTEP students. The website included resources related to budgeting, financial habits and routines, saving money, financial aid, credit and debt, financial stress, family financial responsibilities, and campus support services. The toolkit was disseminated through campus presentations, stakeholder engagement, organizational outreach, and SGA social media.
Results: The website received 155 visitors during implementation. Among 13 students with complete evaluation responses, …
T Cells Modulate The Development And Maintenance Of Painful Paclitaxel-Induced Peripheral Neuropathy In Rnu Rats, Ahmed Olalekan Bakare, Gerard Limerick, Vasudha Goel, Ratan K Banik, Lei Zheng, Andrew J Shepherd, Kristine Glunde, Qin Zheng, Eellan Sivanesan
T Cells Modulate The Development And Maintenance Of Painful Paclitaxel-Induced Peripheral Neuropathy In Rnu Rats, Ahmed Olalekan Bakare, Gerard Limerick, Vasudha Goel, Ratan K Banik, Lei Zheng, Andrew J Shepherd, Kristine Glunde, Qin Zheng, Eellan Sivanesan
Faculty, Staff and Student Publications
The role of T cells in chemotherapy-induced peripheral neuropathy (CIPN) is complex and shaped by biological and experimental factors, including sex, hormonal status, genetic background, and cancer model. This complexity has contributed to inconsistent findings among studies, limiting therapeutic progress. In this study, we investigate how T cells contribute to painful paclitaxel (PTX)-induced peripheral neuropathy (PIPN). Adult male T cell-competent (RNU+/−) and T cell-deficient (RNU−/−) rats were subcutaneously inoculated with tumor cells and subsequently treated with intraperitoneal PTX (8 mg/kg total dose). Reflexive (mechanical, heat, cold) and non-reflexive (burrowing, gait) pain behaviors were assessed from baseline through week 6. Immunohistochemistry …