Digital Commons Network^™

Freeze-Dried, Not Frozen: Lyophilized Mesenchymal Stromal Cell-Derived Extracellular Vesicles And Therapeutic Function In Neuroinflammatory Models, Janet R Ashley, Aidan M Collier, Scott D Olson, Charles S Cox

Faculty, Staff and Student Publications

Background: Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) offer a promising acellular therapy for immune modulation, but clinical translation is hindered by variability and storage constraints. Lyophilization (freeze-drying) could enable shelf-stable EV therapeutics, although its effects on biological activity remain incompletely defined.

Study design: We compared the immunomodulatory effects of frozen and lyophilized EVs from bone marrow (BM), adipose tissue (AD), and umbilical cord (UC) MSCs using lipopolysaccharide-stimulated rodent splenocytes and microglial models and human peripheral blood mononuclear cells (PBMCs). Variables included batch scale (small vs large), cytokine priming, and MSC source. Tumor necrosis factor alpha (TNF-α) secretion was measured …

Digital Communication Strategies For Culinary Medicine In Cancer Prevention And Survivorship: Information-Seeking Habits And Content Preferences Of Online Cooking Media Among Adults Participating In Four Cancer Prevention And Control Cohort Studies, Margaret Raber, Sara Fares, Maria Vazquez, Larkin Strong, Carrie Daniel-Macdougall, Lorna Mcneill, Karen Basen-Engquist

Faculty, Staff and Student Publications

Introduction

Poor diet and excess weight have been linked to increased risk for at least 13 types of cancer. Culinary medicine utilizes experiential cooking skill development to improve individuals’ capacity for healthy eating. Digital communication strategies offer pathways for scalable culinary medicine interventions, but little research has explored how online cooking tools could be leveraged for cancer prevention messaging. We conducted a cross-sectional survey study exploring online cooking information-seeking habits and content preferences among participants in four cancer prevention and control cohorts to inform future digital culinary medicine interventions.

Methods

A cross-sectional survey study was conducted with a convenience sample …

Supporting Financial Well-Being Through Habits And Routines: An Occupational Therapy Online Toolkit For College Students, Diana Cadena

OT Doctoral Capstones

Purpose: This doctoral capstone project aimed to support financial well-being among UTEP students by providing accessible, occupation-based resources to promote healthy financial habits and routines.

Methods: An occupational therapy-informed financial wellness toolkit, Miner Money Matters, was developed as a website for UTEP students. The website included resources related to budgeting, financial habits and routines, saving money, financial aid, credit and debt, financial stress, family financial responsibilities, and campus support services. The toolkit was disseminated through campus presentations, stakeholder engagement, organizational outreach, and SGA social media.

Results: The website received 155 visitors during implementation. Among 13 students with complete evaluation responses, …

T Cells Modulate The Development And Maintenance Of Painful Paclitaxel-Induced Peripheral Neuropathy In Rnu Rats, Ahmed Olalekan Bakare, Gerard Limerick, Vasudha Goel, Ratan K Banik, Lei Zheng, Andrew J Shepherd, Kristine Glunde, Qin Zheng, Eellan Sivanesan

Faculty, Staff and Student Publications

The role of T cells in chemotherapy-induced peripheral neuropathy (CIPN) is complex and shaped by biological and experimental factors, including sex, hormonal status, genetic background, and cancer model. This complexity has contributed to inconsistent findings among studies, limiting therapeutic progress. In this study, we investigate how T cells contribute to painful paclitaxel (PTX)-induced peripheral neuropathy (PIPN). Adult male T cell-competent (RNU+/−) and T cell-deficient (RNU−/−) rats were subcutaneously inoculated with tumor cells and subsequently treated with intraperitoneal PTX (8 mg/kg total dose). Reflexive (mechanical, heat, cold) and non-reflexive (burrowing, gait) pain behaviors were assessed from baseline through week 6. Immunohistochemistry …

The Lysine Demethylase Kdm4c Is An Oncogenic Driver And Regulates Erk Activity In Kras-Mutant Pancreatic Ductal Adenocarcinoma, Menna-T-Allah Shaheen, Sarah Dhebat, Kimal I Rajapakshe, Bidyut Ghosh, Benson Chellakkan Selvanesan, Shariq S Ansari, Cara L Haymaker, Dorsay Sadeghian, Huamin Wang, Ching-Fei Li, Haoqiang Ying, Anirban Maitra

Faculty, Staff and Student Publications

Deregulation of proteins involved in chromatin regulation is common in pancreatic ductal adenocarcinoma (PDAC). Lysine demethylase 4C (KDM4C) is one of the chromatin-modifying proteins frequently overexpressed across multiple solid cancers and is linked to chromatin instability, increased cell proliferation, and enhanced stem cell–like behavior. We observed upregulation of KDM4C protein in a panel of human PDAC cell lines and patient samples compared with nonneoplastic controls. CRISPR/Cas9-mediated deletion of KDM4C in human and murine PDAC cells reduced proliferation, clonogenicity, and increased survival of orthotopically implanted murine PDAC allografts. Transcriptomic and proteomic analyses revealed that loss of KDM4C in both human and …

Prickle4 Drives Microenvironmental Remodeling And Resistance To Parp Inhibition In Idh-Mutant Glioma, Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T Huse, Bo Chen, Timothy A Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang

Faculty, Staff and Student Publications

Mutations in isocitrate dehydrogenase (IDH) genes sensitize gliomas to PARP inhibition (PARPi) by inducing epigenetic reprogramming of DNA damage repair circuits. However, tumors treated with PARPi eventually relapse despite initial responsiveness. In this study, it is demonstrated that the anti-angiogenic agent lenvatinib synergizes effectively with PARPi, resulting in substantial tumor regression and significantly extended survival. Genomic analysis of tumors reveals that PARPi induces widespread transcriptomic changes that are predominantly pro-inflammatory, thereby promoting tumor angiogenesis. Prickle4, a planar cell polarity protein, is identified as a critical mediator of PARPi-induced neovascularization. Targeting Prickle4 effectively overcomes PARPi resistance in these tumors. Collectively, these …

Indicators Of Mid-Career Teacher Quality Through Perspectives Of Key Stakeholders, Maria Azfar Karimullah, Wayne G. Cotton, Louisa Peralta

Australian Journal of Teacher Education

The ongoing quest of quality education has focused on teaching quality in K-12 classrooms globally, as evidenced by recent research, reviews, and media coverage. Yet, identifying, defining, and measuring ‘teacher quality’ remains a complex challenge, particularly during the crucial mid-career stage. The focus on mid-career teachers in educational research is often neglected, when compared with early career teachers or teachers in leadership. This qualitative study explores the characteristics that mid-career teachers, teacher leaders and accreditation personnel perceive as the indicators of a quality mid-career teacher. Drawing on semi-structured interviews with 29 participants including 23 mid-career teachers, five school principals, and …

Exploring Technology Supporting Explicit Teaching And Learning Of Educator Skills And Knowledge: An Ipa Study, Renee Crawford

Australian Journal of Teacher Education

Teacher shortages and increasing accountability measures have placed pressure on initial teacher education (ITE) programs to demonstrate their impact on graduate readiness. This study aimed to explore how technology can support explicit teaching and learning of educator skills and knowledge within a constructivist blended learning framework. Using an interpretative phenomenological analysis (IPA) approach, the research examined preservice teachers’ (PSTs) perceptions and experiences during and after completing an ITE secondary music methods unit where the approach was implemented and modelled. Results indicate that making pedagogy visible through technology enhanced strategies provided PSTs with opportunities to develop critical skills and knowledge aligned …

Lied Center For Performing Arts Strategic Analysis, Daniel Cutler

Honors Program: Senior Projects (Public)

This video essay develops a strategic analysis of the Lied Center for Performing Arts through an interview with an associate director at the Center, personal experiences working for the Center, and other external research. It starts with an introduction to the Lied Center, including its mission, vision, and activities. Using strategic frameworks, namely PESTEL analysis and Porter’s Five Framework, a general analysis of the Center’s industry is conducted. These frameworks demonstrate the difficult landscape the Center finds itself in, with some of the more notable struggles stemming from economic factors and competition from other entertainment venues. From there, suggestions and …

Provoking Generative Ai Futures: Merging Theory And Praxis, Regina M. Luttrell Ph.D., Nick Bowman

Media Studies - All Scholarship

An accessible exploration of the myriad applications and challenges of generative AI for media and communication students, scholars, and practitioners alike.

The latest emergence of increasingly low-cost and scalable AI technologies presents a point of both celebration and concern for the contemporary media and information ecosystem. To this end, this edited volume gathers media and communications scholars and practitioners to engage in discussions and exchange ideas about current trends and developments in the field. Questions this volume asks include: What are the essentials of generative AI from a media and communication perspective? How has generative AI influenced research and scholarship? …

The Professional Constructor, Full Issue

The Professional Constructor

Full Issue, Winter 2026

Volume 50, Number 01

Excluded At The Root: Health Insurance Discrimination Against Hair Loss Conditions, Stacey A. Tovino, Tracy Hresko Pearl

Faculty Articles

No abstract provided.

The Unconstitutional Attempt To Criminalize Naming Ice Agents, Noah C. Chauvin

Faculty Articles

Some members of Congress propose to make it a crime to publish the name of a federal official with the intent of obstructing that official’s law or immigration enforcement duties. This Essay considers whether the lawmakers’ bill, the Protecting Law Enforcement from Doxxing Act, is consistent with the First Amendment. It is not.

Generative Ai And The Purpose Of Legal Scholarship, Michael L. Smith

Faculty Articles

What does generative artificial intelligence mean for the future of legal scholarship? The topic has been the talk of the town around academic watercoolers. Some legal scholars have tried their hand at producing legal scholarship using generative Al. The accompanying commentary is varied, but advocates for the technology suggest that generative Al may become a common tool for legal scholars, leaving those who refuse to adapt at a severe disadvantage.

In this article, I contemplate a world in which legal scholars routinely use generative Al to produce academic writing. I argue that an instrumental view of legal scholarship's value-a view …

Meat Is Dead, Melissa D. Mortazavi

Faculty Articles

The legal and cultural landscape surrounding meat in the United States is evolving as plant-based alternatives, GMO farm animals, and cell-cultivated meat move from test tube to table. While global demand for meat rises amid environmental, ethical, and resource challenges, cell-cultivated meat emerges as a scientifically viable alternative, offering identical nutritional value without the drawbacks of conventional livestock production. Despite federal regulatory approval from USDA and FDA, multiple states have enacted unusually restrictive laws—including bans— targeting cell-cultivated meat. These are motivated largely by economic protectionism, but also deeper cultural anxieties tied to tradition and identity. This Article argues that food …

What Is Terrorism?, Karl T. Muth, Alice Locatelli

Journal of Air Law and Commerce

Is Gotham's Joker a terrorist? What about a school shooter? As we approach the twenty-fifth anniversary of the 9/11 attacks, the United States still lacks a monolithic legal definition of 'terrorism,' creating a dangerous 'motive gap' between federal statutes. This Article analyzes the friction between the motive-heavy definition of 'domestic terrorism' in Title 18 (which includes a mens rea aspect) and the conduct-focused definition of 'terrorist activity' in Title 8 (which focuses on overt acts). Using the hijacking of Flight 93 and the Columbine shootings as case studies, we demonstrate how Title 18's political requirement creates a coverage void for …

Not Quite Fit To Fly: A Reflection On Due Process And Agency Rulemaking In The Faa’S Approach To Pilot Certification, Emily Ryter

Journal of Air Law and Commerce

Judicial and legislative involvement in agency rulemaking is a relevant and particularly salient topic. The authority of an agency to make sound policy with flexibility and discretion often comes into conflict with the judiciary’s duty to prevent arbitrary regulations, which lack solid evidence or convincing rationale. Considering that more than three million passengers fly every day, it is no surprise that establishing a robust certification process for pilots is among the Federal Aviation Administration’s top priorities. The courts and the Legislature have also recently made notable strides to exert more control over the standards for medical certification. In July, the …

Decluttering The Orbital Commons: A Proposal For The Regulation Of Privately Created Space Debris, Rose W. Cobey

Journal of Air Law and Commerce

Space is one of the only resources shared by every person in every country at all times. The problem of space debris is therefore one that affects everyone living on our planet. Scientists and politicians have warned about crowding, collisions, and murky liability for decades, and each of these issues will only worsen without intervention. Space debris has caused damage on Earth since the Space Race, and it now endangers people and property in orbit. We are at an ever-increasing risk of building a wall around our planet and locking ourselves inside. In the last ten years, a new wrinkle …

Critical Feminist Editorial Praxis: My Tenure As The First Journal Editor Of Color Of Communication Monographs, Srivi Ramasubramanian

Media Studies - All Scholarship

In this essay I theorize about Critical Feminist Editorial Praxis, which envisions journal editing as a site for scholar-activism. I use the term activism because to counter the hegemonic whiteness and coloniality of Communication knowledge requires active efforts to go against the taken-for-granted processes and practices. Journal editing is a significant location for interventions because this is often where we learn what is considered cutting-edge scholarship within our discipline. This significance is especially clear when the journal in question is a flagship publication of a leading professional organization. As I end my tenure as the first editor of color of …

The Role Of Media Literacy In Shaping Campus Student Leaders’ Perceptions Of Media Activism, Online Risks, And Social Support, Srivi Ramasubramanian, Minnie Mcmillian, Shumaila Bhatti, Shannon Burth, Julius Matthew Riles, Elizabeth Behm-Morawitz, Melody Wilson

Media Studies - All Scholarship

Campus activism by student leaders has historically played a significant role in social movements. Within contemporary contexts, media is an important site through which campus student leaders raise awareness, share relevant information, distribute online petitions, and shape public discourses on various social issues. Media literacy is an essential skill for student leaders to be effective in their activist initiatives and be able to cope with the inevitable pushback through trolling and cyberbullying that such activism would likely bring up. This survey (N = 855) with college student leaders across three universities explores how they rate themselves on media literacy skills, …

Spa 309 - Spanish Advanced Grammar, Beatriz Lado, Evelyn Duran-Urrea, Tania Avilés

Open Educational Resources

This syllabus is a work in progress developed by Tania Avilés, Evelyn Durán Urrea, and Beatriz Lado. We adapt the traditional grammar-focused course to introduce the study of the Spanish language through a critical sociolinguistic and language-education lens. This approach responds more directly to the needs of our students, many of whom speak language varieties that have historically been stigmatized or marginalized and are training to become Spanish-language teachers.

Students will examine the structure and grammar of Spanish across key domains, including phonetics, morphology, syntax, semantics, pragmatics, discourse, and variation. At the same time, the course situates this structural knowledge …

Spa300 - Introducción A Los Estudios Literarios En Español, Marco Ramirez

Open Educational Resources

Este libro constituye una selección de textos que pueden utilizarse para un curso introductorio a los estudios literarios en español. Los textos seleccionados cubren obras y fragmentos de tres géneros literarios principales: poesía, narrativa y teatro. Este es un material OER y reúne textos de acceso abierto.

“He Will Always Love Me”: Authentic Romance And Reciprocal Love In Otome Games, Elena Yifei Zhao, Nick Bowman

Media Studies - All Scholarship

This study investigates how players construct and articulate emotionally meaningful relationships in otome games. Drawing from 293 open-ended responses from Chinese players, a thematic analysis identified six recurring themes: authentic romance, companionship, shared experience, integration into daily life, game features, and personal growth. The most dominant theme, authentic romance, reveals that players often describe otome boyfriends as emotionally responsive partners who provide validation, support, and affection. Functional descriptions of gameplay mechanics were notably disconnected from other themes (primarily emotional engagement themes). A follow-up analysis of the most popular otome games in the same …

Economic Value Of Agro-Meteorological Services: A Review Of The International Literature, Joseph Manzvera, Kwabena Asomanin Anaman

All Rsif Scholars' Publications

Introduction:

The increasing frequency and intensity of climate-induced extreme weather events, such as droughts, have significantly reduced agricultural productivity worldwide. Enhancing access to agro-meteorological services can mitigate these impacts by improving farmers’ decision-making and adaptive capacity. However, their economic value remains poorly understood, especially in African countries where meteorological services are provided as public goods. Demonstrating their value is critical to stimulate investment and strengthen climate-resilient agriculture.

Methods:

This study reviews and synthesises empirical evidence on the economic value of agro-meteorological services through a systematic literature review and meta-analysis of international studies. Both peer-reviewed and grey literature were analysed to …

Occurrence And Levels Of Multiple Veterinary Antibiotics In Broiler Chicken Processed And Sold In Southern Mozambique, Noemia Andre Mugabe, Jamal Kussaga, Abdulsudi Issa-Zacharia

All Rsif Scholars' Publications

Antibiotic residues in chicken meat pose a health risk to the general public, particularly to sensitive consumers. The aim of this study was to determine the level of antibiotic residues in on-the-market dressed chicken in the Southern Region of Mozambique. A total of 160 samples were randomly collected from eight markets located in five districts in the provinces of Maputo, Gaza, and Inhambane. The residues of β-lactams, quinolones, tetracyclines, and sulfonamides in chicken breast muscle were separated, identified, and quantified using high-performance liquid chromatography (HPLC), coupled with ultraviolet light (UV–VIS). Results revealed that 26.9% of the analyzed samples displayed detectable …

Osteogenic Differentiation Properties Of Blgfs/Odex Hydrogel Doped With Collagen Derived From Chambo Tilapia Fish Skin, Bhahat Lawlley Zimba, Xiaohan Yang, Mwemezi Rwiza, Elingarami Sauli, Shenqi Wang

All Rsif Scholars' Publications

Background

Bone defects caused by trauma, congenital disorders and degenerative diseases such as osteoporosis remain a major clinical challenge, especially in developing regions. Although bone grafting is the current gold standard for treating bone defects, it faces limitations, including donor site morbidity, limited availability and immune rejection. This study developed and evaluated a novel hybrid biomaterial composed of bovine β-lactoglobulin fibrils (BLGFs), oxidized dextran (ODEX) and collagen (COL) extracted from Chambo tilapia fish skin for bone tissue engineering applications.

Methods

BLGFs were synthesized from whey protein, while ODEX was produced by oxidizing dextran. Three biomaterials–COL, BLGFs/ODEX and BLGFs/ODEX/COL–were synthesized and …

Functionalized Blgfs/Odex Hydrogel Scaffold Incorporating Oreochromis Lidole Skin Collagen For Bone Tissue Regeneration, Bhahat Lawlley Zimba, Xiaohan Yang, Mwemezi Rwiza, Elingarami Sauli, Shenqi Wang

All Rsif Scholars' Publications

Background: Bones provide support to the body and protect vital internal organs. Bones have the capacity to repair minor defects, but this ability is substantially impaired in large defects. Mineralization, which is an essential stage of osteogenesis during bone defect repair, occurs through the deposition of calcium phosphate crystals to form the structural framework of bone tissue. In the present study, BLGFs/ODEX/COL hydrogel scaffolds were synthesized and characterized to determine their osteogenic differentiation capabilities. The hydrogel scaffolds were also applied to bone defect in SD rats and the regeneration of bone tissue was assessed. Methods: Whey protein was used to …

Tempering Trademark Tactics: Alloying Anti-Slapp Laws With Massachusetts’ Proven Petition Principles, Brian A. Pattengale

Western New England Law Review

Legitimate criticism of corporate actions or rights creates a free speech dilemma. When speech implicates or even indirectly relates to a trademark, costly litigation can arise where a plaintiff trademark holder is positioned to, or even obliged to, bury a defendant with numerous attendant claims only tangentially related to substantive trademark issues. If those claims are well-pled, the trademark holder succeeds in defeating constitutional speech rights unless the defendant mounts First Amendment defenses against the attendant claims at great cost.

Where a defendant’s speech—trademark or otherwise—is of public value, such lawsuits have been termed strategic lawsuits against public participation (SLAPPs). …

A Prison Of Poverty: How The Current State Of Supplemental Security Income (Ssi) Disincentivizes Saving And Entering The Workforce, Conor Mccormick

Western New England Law Review

Our current Social Security structure provides disability benefits through two programs: Title II Social Security Disability Insurance (SSDI) and Title XVI Supplemental Security Income (SSI). This Note will argue that the current structure of the SSI program actually disincentivizes disabled folk whom are able to work from returning to or entering the work force. A number of factors adversely affect an SSI recipient: (i) the strict definition of “disabled” to mean an inability to engage in a “substantial gainful activity level”; (ii) a cap on the total assets one can hold earn before losing benefits; (iii) poorly framed work incentive …

Evolving Execution Methods: The Constitutionality Of Nitrogen Hypoxia Through Pain, Precedent, And Practicality, Reem Haikal

Western New England Law Review

Method-of-execution challenges have intensified as lethal injection protocols face chronic instability. This Article evaluates whether execution by nitrogen hypoxia violates the Eighth Amendment and argues that it does not. The analysis applies Baze and Glossip to two questions: whether nitrogen hypoxia presents a substantial risk of severe pain and whether a feasible and readily implemented alternative would materially reduce that risk. This Article synthesizes historical Eighth Amendment principles with the contemporary record from executions by nitrogen hypoxia, related litigation materials, medical testimony, and physiological literature on inert-gas hypoxia.

The evidence indicates that nitrogen hypoxia typically produces rapid loss of consciousness …