Digital Commons Network^™

Data-Driven Thresholds For Standardized Classification Of Severe Alzheimer’S Disease Neuropathology Using Digital Neuropathology, Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

Alzheimer's disease neuropathological changes (ADNC)—operationalized with semi-quantitative parameters—represent the consensus-based gold standard for diagnostic evaluation of disease severity. Although useful, ADNC diagnostic frameworks have limitations, particularly in advanced disease stages where pathological severity varies widely within a given diagnostic category. Further, some individuals lacking cognitive impairment are inappropriately categorized as having severe ADNC. In this study, quantitative pathology metrics and alternative tissue sampling schemes were integrated with data about premortem cognitive status, in order to derive clinically informed neuropathologic diagnostic thresholds. Specific goals of the current study were to generate data-driven, standardized diagnostic cut-points, with the most severe stages of …

Clonal Expansion Of Cytotoxic Cd8⁺ T Cells In Lecanemab-Associated Aria, Lance A. Johnson, Kai Saito, Akhil V. Pallerla, Jessica L. Funnell, Ashley R. Ezzo, Chelsea M. Song, Douglas A. Harrison, Noah J. Norton, Lauren C. Moore, Linda J. Van Eldik, David W. Fardo, Greg E. Cooper, Josh M. Morganti

Sanders-Brown Center on Aging Faculty Publications

Amyloid-related imaging abnormalities (ARIA) are the principal safety concern limiting anti-amyloid therapies for Alzheimer’s disease, yet their biology remains unclear. Here we show, through multi-omic profiling of peripheral blood from three ARIA+ patients and matched controls, that ARIA is associated with coordinated reprogramming of CD8 + T cells. CD8+ effector memory (TEM) and terminally differentiated (TEMRA) subsets were expanded, clonally enriched, and transcriptionally primed for cytotoxicity and vascular trafficking. Transcription factor inference and metabolomics converged on glycolytic reprogramming favoring short-lived effector function. Ligand-receptor modeling revealed enhanced monocyte-to-T cell signaling through antigen presentation, adhesion, and chemokine axes, while integration with a …

Developing A Community-Driven, Locally Sourced Medically Tailored Meal Model: A Pilot Linking Healthcare, Farmers, And Patients, Julie Brown, Ashton Potter, Leandra Forman, Jairus J. Rossi, Anna Cason, Christa Mayfield, Alison Gustafson

Dietetics and Human Nutrition Faculty Publications

Background: Food is Medicine (FIM) programs improve health outcomes by integrating nutrition interventions into healthcare delivery, yet gaps remain in community partner capacity and local food system integration. This program aimed to build community capacity to develop a locally sourced, medically tailored meal (MTM) model connecting farmers, healthcare providers, and patients. Methods: Meals were developed by a registered dietitian following American Heart Association (AHA) Heart-Check and MyPlate nutrition standards. Recipes were adapted for freezing, scaled for production, and sourced from 26 central Kentucky farms. Eligible participants with hypertension or type 2 diabetes (T2D) were referred through the Food as Health …

Library Advisory Council 2025-2026 End Of Academic Year Report, Central Washington University

Library Advisory Council for CWU Libraries

Library Advisory Council 

2025-2026 

End of Academic Year Report 

Infringement Through Imitation: Ai Chatbots And The Characters They Infringe, Isabella Herrera

Fordham Intellectual Property, Media and Entertainment Law Journal

Chatbots that purport to embody the personas of copyrighted characters are poised to be a central issue for the IP legal field and the entertainment industry. In September of 2025, Disney sent a cease-and-desist letter to Character.AI, a leader in the “character” chatbots market, demanding removal of numerous chatbots that were reportedly based on characters from Disney franchises like Star Wars, Marvel, and the Pixar films. Character.AI allegedly removed all infringing characters, however it remains unclear whether character chatbots platforms are required to do so under IP law. This Note addresses the issue of copyright infringement for character chatbots and …

Knowledge Based Automated Planning For Non-Coplanar Vmat Stereotactic Radiosurgery In Ocular Malignancies, Chase Cochran, Shane Mccarthy, William St. Clair, Damodar Pokhrel

Radiation Medicine Faculty Publications

Background and Purpose: Stereotactic radiosurgery/radiotherapy (SRS/SRT) has emerged as a less invasive alternative to enucleation in the management of ocular malignancies. SRS/SRT planning is time-consuming, complex, and the plan quality depends on the experience of the treatment planner. We demonstrate the use of RapidPlan modeling in conjunction with HyperArc for the treatment of ocular diseases to improve planning efficiency, consistency, and quality.

Materials and Methods: A HyperArc-based RapidPlan (HARP) model was iteratively trained on 80 patient datasets that simulated ocular malignancies. Twenty additional patient datasets were reserved for model testing and comparison with manual plans. Each testing dataset was both …

Designing Theranostic Radiopharmaceutical Trials For Uterine Cervix Cancer, Denise Fabian, Molly E. Buffington, Brianna S. Cagle, Steve M. Keefe, Michael K. Schultz, Charles A. Kunos

Radiation Medicine Faculty Publications

Designing and interpreting early phase trials of theranostic radiopharmaceuticals remains challenging because it is difficult to isolate effective levels of activity in enriched patient populations that would be worth following up in later-phase development. This study explores the known challenges and emerging opportunities for clinical research on patients with uterine cervical cancer. We identified eight randomized combination trials for advanced-stage uterine cervix cancer that were activated between 2011 and 2022 and tabulated their results to determine whether combinations were better than individual constituents and which suitable study population is best situated for the study of a new theranostic agent. In …

Broadening The Fetal Alcohol Paradigm: Bdnf Methylation As A Link Between Paternal Alcohol Use And Offspring Neurodevelopmental Deficits, Caitlin E. Muñoz

Scripps Senior Theses

Developmental effects of fetal alcohol exposure are extensively documented as a consequence of maternal gestational alcohol consumption. However, similar consequences of paternal alcohol consumption remain understudied. This proposed pilot study will examine preconception paternal alcohol consumption within its capacity to induce heritable epigenetic modifications in sperm, such that offspring are susceptible to adverse in utero neurodevelopment and neonatal neurobehavioral outcomes. Specifically, it will examine DNA methylation patterns along the brain-derived neurotrophic factor (BDNF) exon IV promoter in paternal spermatozoa. BDNF exon IV is considered a key locus in neurogenesis regulation, synaptic plasticity, and cortical development. It is hypothesized that BDNF …

Ghostwriting The Government, Bridget C.E. Dooling

Marquette Law Review

Ghostwriting is when a writer prepares materials to be issued under someone else’s name. The word describes a politician’s use of a speechwriter, a student’s purchase of a term paper, or a tongue-twisted admirer asking a poet to craft a love letter on his behalf. It also happens inside organizations every day: staff draft documents for others “up the chain” to sign. But when legislators rely on staff and lobbyists to draft bills, when an agency head relies on staff or contractors to write a rule, and when a judge relies on her clerk for a draft opinion, the benefits …

Public Rights, Democracy, And The Separation Of Powers, James L. Huffman

Marquette Law Review

This Article examines the concept of public rights in the contexts of democratic governance and the constitutional separation of powers. While the concept of public rights has a long history in Anglo-American law, over the last several decades, the term is often employed with only vague reference to its historic meanings and with little or no definition. With reliance on the centrality of the concept of rights in American constitutional government, it is commonly claimed that public rights, like private rights, can be enforced in the courts as constraints on legislative and executive actions.

In American caselaw public rights have …

Collegial Support As A Key Component Of Beginning Special Education Teacher Retention, Olivia A. Brammer

All Electronic Theses and Dissertations

This thesis reviews current studies to examine how collegial support is a key component of beginning special education teacher retention through classroom and instructional support, observations and coaching, and emotional and mental health support. The literature shows that across rural and urban school districts in the United States, colleagues and their support play an important role in the retention of beginning special education teachers. The thesis also points to the need for further research on mentorship and induction programs for beginning special education teachers as they navigate their unique roles. While the results show the impact of collegial support on …

Finding Meaning And Value In Old Age, Jane Nell Morgan

All Electronic Theses and Dissertations

This project addressed finding meaning and value in old age. The research conducted explored barriers to achieving meaning and value and how to overcome those obstacles. The research specifically focused on senior adults who reside in a Christian-based assisted living home located in the Twin Cities, Minnesota. In response to this problem, the researcher studied the lives of three older biblical characters, Jacob, the author of Psalm 71, and Anna, and reviewed relevant literature on barriers senior citizens face today. In addition, research included the damaging effects older adults face when they fail to find meaning in their lives and …

The Presence Of Predators Moderates Evolutionary Responses Of Trinidadian Killifish To A Novel Parasite, Anne E. Christian

Biology Dissertations

The Healthy Herds Hypothesis suggests the idea that prey populations derive a benefit from their predators: predators reduce the exposure of their prey to infectious disease, both by limiting prey population densities and by eliminating sick individuals. Much research has focused on the balancing effect that predators have on ecosystems. There is a current need for research into whether these effects cause evolutionary shifts in prey populations, where strong predation pressure prevents prey species from evolving physiological tolerance or resistance to infectious agents. Parasites especially often have rapid effects on host evolution, due to exploitative interactions.

I seek to address …

Work In Progress: The Impact Of Classroom Interventions On Student Success And Retention In Electric Circuits, Cherian Mathews

All Faculty Articles - School of Engineering and Computer Science

University of the Pacific has embarked on a university-wide endeavor to improve student success and retention. This effort involves academic coaches being placed in each unit, early grade reporting in the fifth week of the semester, follow-ups by faculty advisors and academic coaches for struggling students, and documentation of interactions with such students in the university CRM system. These follow-ups with students typically involve conversations to explore factors contributing to poor performance (e.g., health issues, excessive work hours, study skills), suggesting approaches to improve performance, and making referrals to care teams and supplemental instruction. Despite all these efforts, DFW rates …

Lived Experiences Of Men Working In Both White-Collar And Blue-Collar Jobs: A Systematic Literature Review, Pius Omolewa, John Bressan, Nassrine Noureddine, Adekemi Adedipe

All Faculty Scholarship

The objective of this systematic review was to identify, appraise, and meta-synthesize qualitative evidence regarding the experiences and perceptions of men in both white-collar and blue-collar jobs. The systematic review of qualitative studies searches was conducted in MEDLINE, Scopus, EBSCohost, ProQuest, CINAHL, and PsycINFO of articles published between 2005 and 2025 to ensure information is current and relevant to modern practices and to analyze trends and the evolution of a research field over a significant period of 20 years. In total, 2,074 articles were identified, and after screening using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, …

Personal Strength As A Core Dimension Of Posttraumatic Growth: A Multi-Method Study Of U.S. Military Veterans, Steven Moore

Social Work Dissertations

U.S. military veterans are frequently exposed to traumatic and morally challenging experiences that can disrupt core assumptions about identity, purpose, and control. While much of the veteran mental health literature has emphasized psychological distress and functional impairment, growing attention has been directed toward posttraumatic growth and strengths-based outcomes. This dissertation examined posttraumatic growth among U.S. military veterans with a specific focus on personal strength as a central dimension of growth following trauma.

Using a multi-method design, this dissertation integrated findings from three complementary studies. First, a scoping review mapped how posttraumatic growth, personal strength, and related constructs have been conceptualized, …

Que Ondee Sola - Winter 2026, Xavier Morales-Greene

Que Ondee Sola

Student publication founded in 1972, articles include:

Wear Your Crown Freely, Boricua Feminism and the Fight for Decolonization, Envision Community Services Provides 14 Years of Restorative Justice in Pilsen, If You Loved Me- Intimate Partner Violence in Latin Communities, Cosas and Linda from Guarida de Cosas, No Kings Protest 2025, We Won! HITN Takes Home Three Emmys at 68th New York Awards, Our History is a History of Solidarity, Ramon Lopez- The Ethnographer of Paseo Boricua, The United Shits of Amerikkka, Stop the Deportation of 340,000 Haitians with Temporary Protected Status, The Journey of South American Immigrants, Austin, Acostumbrando el …

Determinants Of Forward-Looking Information Disclosures Among Nonfinancial Firms In An Emerging Economy, Ikponmwosa Michael Igbinovia, Oluwaseun Joy Rapheal

Journal of Accounting Auditing and Business

The disclosure of Forward-looking information (FLI) is non-mandatory. The study investigates the determinants of FLI by examining specific corporate governance and firm-level variables known from disclosures literature to be core determinants of voluntary disclosures. The investigation relied on data from 29 non-financial listed companies in a developing country over the period 2018 to 2023. From a positivist philosophy, the study adopted a quantitative approach. The authors employed a comprehensive methodological approach, involving the use of Descriptive Statistics, Panel Correlation, Panel Hausman Test, and the Panel Random Effects Model (REM). A balanced panel of 174 firm year observations was used to …

Confessions From The Barre: Embodying The Impossible Ideal Body Worker, Jessica M. Rick

Faculty Publications - Communications

This autoethnographic manuscript examines how ideal worker norms operate through embodied discipline within commercial fitness culture by tracing my experiences as a plus-size barre instructor. Drawing on feminist autoethnography and organizational communication scholarship, I introduce the concept of the impossible ideal body worker to describe how instructors are simultaneously required as labor yet persistently misaligned with aspirational aesthetics. I analyze how fitness labor demands not only physical competence but aesthetic compliance, emotional regulation, and continual bodily self-surveillance. Structured to mirror the arc of a barre class – from Warmup to Cool Down – the manuscript reveals how organizational power circulates …

Artificial Intelligence Methods For Circadian Rhythm Recovery And Disease Identification From High-Dimensional Omics Data, Aram Ansary Ogholbake

Theses and Dissertations--Computer Science

High-throughput transcriptomic and proteomic technologies have enabled opportunities for studying biological processes and disease mechanisms. However, extracting meaningful biological information from these high-dimensional datasets remains challenging due to limited sample sizes, biological heterogeneity, measurement noise, and the absence of biological annotations. In particular, many molecular datasets lack temporal information required for circadian analysis, making the study of circadian rhythms difficult. Moreover, disease diagnosis and biomarker discovery from transcriptomic data often rely on complex machine learning models whose predictions are difficult to interpret and may not generalize well across independent datasets and experimental platforms. These limitations motivate the development of artificial …

The Cost Of Care: A Mixed Methods Study Of Social Work Student Well-Being, Practicum Pay, And The Future Of Feminized Care In The Health Workforce, Christian Adeleke

Social Work Dissertations

Social work field education, commonly enacted as the practicum, is widely regarded as the profession’s signature pedagogy, yet its material conditions—particularly the prevalence of unpaid or minimally compensated placements—are rarely problematized. This dissertation examined the financial, academic, and well-being consequences of practicum participation among social work students and the mechanisms through which these consequences arise. Using an embedded mixed methods design, the study analyzed secondary data from the Payment for Placements (P4P) survey (N = 618), combining a moderated-mediation structural equation model with a reflexive thematic analysis of open-ended narrative responses. Drawing on feminist political economy and social reproduction …

Editorial For Issue 20(1), Jeff Moe, Peighton Corley, Aaron Albright

Counseling & Human Services Faculty Publications

[Introduction] Hello and welcome to the community of counselors, advocates, and scholars who read the Journal of LGBTQ Issues in Counseling. In our era of continued political attacks and undermining of gender diverse and sexual orientation diverse people, our editorial board remains committed to creating knowledge that speaks to the inherent worth of LGBTQIQA+ people and related groups. Our histories and communities are dynamic, and we continue to shape standards of care and best practice that not only improve the mental health and well-being of gender diverse and sexual orientation diverse people but help improve the lives of all people …

Counseling And The Neurodiversity Paradigm: A Call To Action, Emily Goodman-Scott, Rawn Boulden, Aaron Albright, Jenna Alvarez, Betsy M. Perez

Counseling & Human Services Faculty Publications

The counseling profession is rooted in prevention, wellness, mental health, and a critical social justice approach to serving historically marginalized communities, including people with disabilities. The overarching construct of disability comprises subtypes, such as neurodivergence. Given the prevalence of neurodivergent individuals worldwide (approximately 15%-20%), the counseling profession must be prepared to support this community. At the same time, there is a dearth of peer-reviewed literature on neurodiversity specifically for the counseling profession. In this article, we address a timely topic in the profession. We discuss utilizing a critical counseling lens and centering marginalized identities, such as people with disabilities; prominent …

Spirituality And Psychological Well-Being In College Students: Does Resilience Mediate This Relationship, Kevin C. Snow, Jessica Starken, Lindsay A. Phillips

Counseling & Human Services Faculty Publications

Given continued challenges of college transition and recent changes (e.g., COVID) leading to increased use of college counseling services and past studies exploring spiritualty/religion and resilience pertaining to psychological well-being (PWB), this study explored the relationship between spirituality, resilience, and PWB in college students. Three scales, the Connor-Davidson Resilience Scale, Daily Spiritual Experience Scale, and the Ryff Psychological Well-Being Scale, were used to measure the relationship between spirituality, resilience, and PWB. Results of this study showed support for the relationship between spirituality, resilience, and PWB in college students. Results also lend support for future research exploring therapeutic incorporation of spirituality …

Back To The Drawing Board? Overdraft Fees, The Congressional Review Act, And The Cfpb's Path Back To Consumer Protection, Kaitlin A. Caruso

Faculty Publications

In late 2024, the Consumer Financial Protection Bureau adopted a rule aimed at addressing a longtime pain point for consumers: high, sometimes unpredictable, overdraft fees. The CFPB predicted that the rule would save consumers billions of dollars per year. But it was not to be. The second Trump Administration has taken unprecedented, sometimes unlawful, action to incapacitate and dismantle the CFPB. The President and Congress have also worked together to use an unusual statutory tool, the Congressional Review Act, to not only to kill the overdraft rule but also keep the CFPB from adopting any regulation that is “substantially the …

Reverse Koebner Phenomenon In Linear Scalp Morphea Following Punch Biopsy: A Rare Therapeutic Response, Suhas C. Gowda, Akshay Samagani, Shreyas C. Gowda

Digital Journal of Clinical Medicine

Morphea is a chronic immune-mediated fibrosing disorder characterized by excessive collagen deposition in the skin. Linear morphea of the scalp (en coup de sabre) commonly demonstrates the Koebner phenomenon, wherein lesions develop at sites of trauma; however, the reverse Koebner phenomenon—trauma-induced regression—is exceptionally rare. We report an unusual case of linear scalp morphea showing early regression following a diagnostic punch biopsy. A 71-year-old male presented with an asymptomatic, indurated linear plaque on the scalp of two months’ duration. Histopathology from a 3.5-mm punch biopsy confirmed morphea, demonstrating dense collagen bundles with lymphoplasmacytic infiltrate. At follow-up eight days after …

Humanizing The Base Of The Pyramid: Exploring The Influence Of Resource (Dis)Advantages On Value Creation, Ted London, Lisa Jones Christensen, Tyson Mackey, Alison Mackey, Heather Esper, Andrew Grogan-Kaylor

Faculty Publications

Base of the pyramid (BoP) scholarship emphasizes the potential for enterprises to generate profits by enhancing the wellbeing of the impoverished, often by selling socially-beneficial products (SBPs). Yet, many such BoP enterprises have experienced mixed results. We argue that this may stem from insufficient attention to how BoP consumers value SBPs and other products. We frame SBPs as a type of human capital investment and thus use human capital theory to study how the consumption of SBPs does or does not create value for consumers. Specifically, we use a novel data set from rural India to measure value creation in …

2026 Acropolis, Whittier College

Acropolis (Yearbook)

No abstract provided.

Experiencing Objectification In Platform Work: Food Delivery Riders’ Accounts Of Organizational Absence And Self-Valuation, Emerald Jay D. Ilac, Ma. Tonirose D. Mactal, Clarisse Aeaea M. Kilboy

Leadership and Strategy Faculty Publications

This study aimed to explain how food delivery platform riders experience objectification in the context of platform-based work, with particular attention to how organizational practices and leadership shape experiences of marginalization, dignity, and voice. A qualitative design was employed using Descriptive Phenomenological Analysis. In-depth interviews were conducted with nine food delivery platform riders to describe the essential structures of their lived experiences of objectification. Subaltern Theory was used as an interpretive lens in making sense of the findings. Five experiential themes were identified: (1) leaders’ non-presence resulting in perceived abandonment, (2) leaders’ devaluing of food delivery riders, (3) social devaluation …

Removing Of Erroneous Penicillin Allergy Labels (Repeal), Neil Powell

School of Biomedical Sciences Theses

BackgroundPenicillin allergy records are common; 15% of hospital inpatients report a penicillin allergy record, but the majority, estimated to be >95%, can take penicillin after formal testing. Penicillin allergy records are associated with several patient, healthcare-system and wider societal harms thought to be due to the avoidance of non-penicillin antibiotics, which are often first line for common infections. Testing patients with penicillin allergy records and removing them if they test negative is called penicillin allergy de-labelling and is traditionally the role of allergists. More recently, non-allergy healthcare workers have been shown to be able to safely remove low risk penicillin …