Digital Commons Network^™

Racial And Ethnic Disparities In Clinical Characteristics And Outcomes In Adults With Encephalitis: A Retrospective Study, Sienna Wu, Rodrigo Hasbun, Ralph Habis, Jordan Benderoth, Ivany Patel, Ashutosh Gupta, Megan Goyal, Arun Venkatesan, John C Probasco, Paris Bean, Ashley Heck, Laya Rao, Rajesh K Gupta

Faculty, Staff and Student Publications

Background and objectives: This study aims to assess whether adult patients with encephalitis from different racial and ethnic backgrounds exhibit significant differences in clinical presentation, diagnostic findings, and outcomes.

Design and methods: A retrospective cohort study was conducted by utilizing the electronic health records of encephalitis patients in the greater Houston and Baltimore areas. Patients were categorized by race/ethnicity into White or ethnic minority (including Black, Hispanic, and Asian patients). Data was analyzed for the presence of significant differences in clinical characteristics between the two groups.

Results: Among 599 patients, 312 (52.1%) were White and 287 (47.9%) were of an …

Thoracolumbar Fractures: Historical Systems And Advancements With The Ao Spine Classification, Barry Ting Sheen Kweh, Alex R. Vaccaro, Gregory D. Schroeder, Jose A. Canseco, Maximilian Reinhold, Mohamed M. Aly, Sebastian Bigdon, Mohammad El-Skarkawi, Richard J. Bransford, Andrei Fernandes Joaquim, Harvinder Singh Chhabra, Emiliano Vialle, Rishi M. Kanna, Charlotte Dandurand, Cumhur Öner, Jin Wee Tee

Rothman Institute Papers

Study Design: Systematic Review. Objective: To describe the historical classifications of thoracolumbar injuries and their evolution into the AO Spine Thoracolumbar Injury Classification System. Methods: A systematic review of MEDLINE, EMBASE and Cochrane Databases was performed in keeping with Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Results: 445 articles were crystallized to 14 included studies. Simple categorization systems offered by Bohler or Watson-Jones merely identify fracture morphology. Holdsworth and Denis conveyed a sense of the stability of injuries by noting columns of stability, but still failed to take into consideration important factors such as neurological status or …

A New Frontier For An International Right With No Frontiers: Freedom Of Expression & Generative Ai Outputs, Evelyn Aswad

Faculty Articles

As people debate whether the First Amendment protects generative AI outputs, we should also reflect on what the global freedom of expression standard has to say on the matter. This standard will affect discussions around national and regional regulatory approaches to generative AI throughout the world. In addition, global corporate responsibility standards call on companies to respect international human rights in their operations, which may also impact how businesses that provide generative AI services approach their activities.

I argue that the global free expression standard protects the rights of individuals to seek and receive information of any kind, including gen …

Comparative Analysis Of M1 And M2 Macrophage Distribution And Localization In Chronic Wounds Of Metabolically Healthy And Diabetic Hosts Using A C57bl/6 Mouse Model, Bryan Liu, Ramiro Cisneros, Nathaniel Primous, Estephania Garcia, Bhuvana Lakkasetter Chandrashekar, Claudia Biguetti

School of Podiatric Medicine - Student Research

Introduction/Purpose: Type 2 diabetes and obesity are major risk factors for delayed wound healing in chronic foot ulcers. This study investigated whether a high-fat diet induces diabetes-like metabolic dysfunction in mice and characterized associated morphological changes and macrophage polarization during wound healing. Macrophages exist as pro-inflammatory M1 and anti-inflammatory M2 phenotypes that regulate tissue repair.

Methods: Ten male C57BL/6J mice (8 weeks old) were divided into high-fat diet (HFD) and regular diet (RD) (IACUC Protocol 22-33) groups.  After 12 weeks, body weight and intraperitoneal glucose tolerance test were measured to confirm metabolic phenotypes, after which a 6mm dorsal excision wound …

Expression Of 5-Lo In Chronic Wounds In A Preclinical Murine Model Of Obesity And Type 2 Diabetes, Joshua Wu, Ramiro Cisneros, Nathaniel Primous, Estephania Garcia, Bhuvana Lakkasetter, Claudia Biguetti

School of Podiatric Medicine - Student Research

Introduction: Diabetes is associated with impaired wound healing and a high incidence of chronic, non-healing ulcers, largely driven by persistent low-grade inflammation. Leukotriene B4 (LTB4), a product of the 5-lipoxygenase (5-LO) pathway, has emerged as a key mediator of this chronic inflammatory state. Hence, this study investigated the role of the 5-LO pathway in cutaneous wound healing under normoglycemic and diabetic conditions using a murine model.

Methods: Twelve 8-week-old male C57BL/6J mice were fed with high-fat diet (HFD; 60% kcal fat) or low-fat diet (LFD; 10% kcal fat) for 12 weeks (IACUC 22-33). Body weight (BW) and fasting blood glucose …

Making The Case For Open Dental Education, Casey D. Wright, Pamela P. Smalley, Fanny Eliza Bondah, Jennifer L. Lehto, Tonia Morley, Danelle Orange, Elisabeta Karl, Royce Kimmons

Library Faculty Research and Publications

Dental education as a field and dentistry as a profession are facing significant challenges, including workforce shortages, ever-rising costs, unmet student and community needs, as well as quality of pedagogical practices. Open educational resources are learning objects that are freely accessible and are able to be retained, reused, revised, remixed, and redistributed under the philosophy of more openness and sharing. While some efforts are being made to address the aforementioned concerns, the prospects of more readily welcoming and adopting open education have not been discussed as a potential means of alleviating these barriers. Here, we expound on some of the …

Crab And Lobster Shell Meal Taste Preferences Of Dairy Heifer Calves, Summer R. Pescinski, Peter S. Erickson

Honors Theses and Capstones

Objective: This preference study was conducted to evaluate the palatability of crab shell meal (CM) and lobster shell meal (LM) when added to calf starter for post-weaned dairy heifer calves.

Materials and methods: Six calves were used for a sequential elimination experiment to rank their taste preferences when offered control calf starter, calf starter mixed with 50 g of CM, and calf starter mixed with 50 g of LM.  The calves were kept on the study for a total of 5-d split into two feeding segments.  Preference was determined by calculating the total intake of each treatment …

Gendered Coverage In Sports Media: An Analysis Of Espn’S Representation Of Women’S Sports, Abigail C. Leonard

Honors Theses and Capstones

Despite growing participation in women’s sports, media coverage continues to reflect significant gender disparities. This thesis examines how ESPN, as a leading sports media network, contributes to the construction of gendered narratives through its coverage of women’s sports and female athletes. Drawing on framing theory, agenda-setting theory, and social identity theory, this study analyzes headlines, visuals, language, narratives, and broadcast patterns to explore how meaning is constructed in sports coverage.

The findings suggest that while coverage of women’s sports has increased, it often remains positioned as secondary to men’s sports. Female athletes are more frequently described using language that emphasizes …

When Does Sexual Image Exposure Constitute Child Sexual Abuse?: Definitional Inconsistencies, Paige B. Kenny

Honors Theses and Capstones

The following review examines how youth exposure to sexual images online is conceptualized and measured as abusive within epidemiological research on online child sexual abuse (OCSA). As digital environments reshape sexual socialization, scholars debate whether and when exposure to sexual content constitutes abuse. To address this issue, this study conducts a qualitative content analysis of 27 survey items drawn from 20 empirical studies of youth online experiences. Survey questions about sexual image exposure were coded across four dimensions: volition, personalization, image or text, and explicitness. Findings reveal significant definitional inconsistency. Many studies rely on ambiguous terms such as “sexual” or …

"That She May Bear On My Knees:" An Adoption Ritual In The Hebrew Bible, Claire Ellen Hobbs

Honors Theses and Capstones

No abstract provided.

The Effects Of Micro- And Nanoplastics On Human Monocytes, Caitlin G. Valerian

Honors Theses and Capstones

No abstract provided.

Exploring Biopsychosocial Influences On Hookup Culture And Disrupting Compulsory Behaviors In Emerging Adults: A Multidisciplinary Analysis Of A Contemporary Public Health Concern, Catherine Benjamin

Honors Theses and Capstones

Multidisciplinary analysis, including biology, psychology, and sociology, to better understand the compulsory Hookup Culture that exists as a contemporary public health concern among the age group defined as emerging adults. Sexually Transmitted Infections (STIs) diagnoses are steadily rising in the United States and disproportionately affecting college students. Early socialization and current educational resources that contribute to shame and stigma are discussed to explain how lifestyle and social conditions can act as risk factors for individual health outcomes.

Enhancing Nursing Education To Improve Care For Women Experiencing A Substance Use Disorder During Pregnancy, Sadie Caddell

Honors Theses and Capstones

Introduction: Nursing education prepares students to care for patient populations by enhancing knowledge of clinical pathophysiology and applying foundational nursing skills to tailor to the unique care requirements of each patient. When analyzing the nursing course curriculums as guides for what is included in nursing education, it is essential to consider relevant patient populations to ensure adequate representation in lectures. Inclusivity of relevant patient populations within curriculums equips students to encounter a variety of patients in a clinical setting. Perinatal substance use has prevalence in the local community of this university, with 6% of all births in New Hampshire in …

Ethical Considerations For Hospice Patients In Inpatient Settings: A Systematic Review And Thematic Analysis, Matthew D. Harry

Honors Theses and Capstones

Hospice care is intended to prioritize comfort, dignity, symptom management, and quality of life for individuals with life-limiting illness. However, when hospice-eligible patients are managed within inpatient hospital settings, significant ethical challenges frequently emerge due to the tension between comfort-focused care and the curative, intervention-driven structure of acute care medicine. This paper presents a systematic literature review and thematic analysis examining the ethical considerations surrounding hospice patients in inpatient settings, with particular attention to clinical decision-making, communication, prognostic uncertainty, moral distress among nurses, and conflicts involving patient autonomy and family wishes. A structured review of peer-reviewed literature was conducted using …

Surveillance Of A Novel Vesivirus Discovered In An Urban Mephitis Mephitis Population, Amanda E. Diggins

Honors Theses and Capstones

Caliciviridae is a family of non-enveloped, positive-sense, single stranded RNA viruses, including eleven defined genera that contain important pathogens of humans and animals. Within the Caliciviridae family, the genus Vesiviridae includes feline calicivirus, a leading cause of upper respiratory disease in cats, and vesicular exanthema of swine virus, a historical disease of domestic swine that has now been implicated in several marine mammal vesicular diseases, one of which has been confirmed zoonotic. Urban landscapes create a unique environment for rapid intra- and interspecies transmission of viruses. Clustered resources attract high-density populations of synanthropic wildlife species, increasing spatial overlap and heightening …

Guidelines For Enhancing Voter Accessibility, Anna Barrows

Honors Theses and Capstones

No abstract provided.

Metabarcoding Ixodes Scapularis To Characterize Feeding Behavior In Comparison To Pathogen Carriage And Geospatial Distribution, Adrianna Kate George

Honors Theses and Capstones

No abstract provided.

Program Notes On Haydn Sonata No. 31 In A Flat, Hob. Xvi. 46, Chopin Nocturne In F Sharp Minor, Op. 48, No. 2, And Prokofiev Visions Fugitives, Op. 22, Lucas Kamon

Honors Theses and Capstones

No abstract provided.

Political Media Hesitancy And Avoidance In College Students, Taylor Mandile

Honors Theses and Capstones

No abstract provided.

Effects Of Perching Behavior In Broilers On Welfare And Production Benefits, Natalie G. Bunn

Honors Theses and Capstones

Broiler chickens are bred for feed efficiency, rapid growth rate, and muscle development. Conventional broiler farms utilize fast-growing breeds that reach market weight rapidly and present welfare concerns. Primarily raised indoors with little enrichment, the genetics and husbandry practices of broilers encourage inactivity and perpetuate health problems such as skeletal deformities, lameness, and pododermatitis. Despite the commonness of these issues, there is little research on the reduction of such health complications through production management. This study investigated methods to promote perching behavior and the effects of riser perch and platform perch utilization in broilers. A mixed flock of slow-growing Gray …

How Historical Experiences Shaped The Italian Constitution: A Comparative Perspective With The United States, Kaitlin M. Rocca

Honors Theses and Capstones

No abstract provided.

Hey, Siri: How Companionate Ai Usage Affects Social Satisfaction And Personal Intelligence, Ryan E. Moran, Marley Ireland

Honors Theses and Capstones

Artificial intelligence is a field that is growing and changing faster than humanity can keep up. While part of the population is benefiting from its unmatched diagnostic power, increased productivity in school and in work, and even its surgical and therapeutic contributions, others are filing lawsuits based on claims that an AI chatbot was a key factor in the mental health crisis of someone they loved. Research has found that reliance on these AI-generated conversational agents can lead to social withdrawal, unrealistic relationship expectations, addictive tendencies, and, in the worst cases, increased or encouraged suicidal ideations, especially in vulnerable populations. …

Concord Public Transportation Improvement Project, Jacob Holt

Honors Theses and Capstones

The capital city of Concord, New Hampshire, has been served by Concord Area Transit (CAT) since 1989. Despite continued population growth and economic development within the city, CAT’s fixed route bus system has remained unaltered since 2011. The purpose of this project is to rework the CAT system to provide service that better aligns with Concord resident’s current needs. A public survey was conducted to gather data regarding Concord resident’s needs, habits, and perception of the existing system, which was used in the development of the revised system. The project includes suggestions for both system-wide and route-specific modifications. Key changes …

Restoring Tidal Function: Hydrologic And Erosion Controls, On Rare Plant Distribution In New Hampshire Salt Marshes, Nikhila B. Lampman

Honors Theses and Capstones

No abstract provided.

Differential Effects Of Growing-Season Climate Anomalies On New England Crop Yields: A 1990-2024 Comparative Analysis Of Heat-Tolerant And Heat-Sensitive Crops, Rhea Shirodkar

Honors Theses and Capstones

As rising temperatures and variable precipitation effects are becoming increasingly prevalent in New England, as does the need to consider how these climate change-induced weather patterns affect the region's agricultural productivity and food system stability. Using annual crop yield data from the United States Department of Agriculture’s National Agricultural Statistics Service (USDA NASS) and growing-season climate anomaly data from NOAA’s National Centers for Environmental Information (NCEI), this study examines how growing-season temperature and precipitation anomalies affect seven major New England crop yields (tomatoes, potatoes, sweet corn, cranberries, carrots, lettuce (head), and apples) over a 34-year period from 1990 to 2024. …

Investigating Microbe-Mediated Temperature Tolerance In Lemna Minor, Matthew Thomas Farbaniec

Honors Theses and Capstones

Temperature limits plant growth and survival more than many other environmental variables, and increases in the frequency of extreme hot or cold weather events pose significant challenges for plant growth and crop yields. Previous studies have shown that bacteria, fungi, and other microorganisms associated with plants ( i.e., the plant microbiome) can influence host response to temperature stress. These same microbes have their own temperature tolerances. We investigated whether microbial temperature tolerance correlates with plant resilience using an aquatic plant model, Lemna minor, and isolates derived from its microbiome. Microbial isolates were assessed at −10°C, 4°C, and 32°C for …

Stress And Reward Interactions In Substance Use Disorder: An Evolutionary Mismatch Framework, Nicholas L. Castrucci

Honors Theses and Capstones

Substance use disorder (SUD) is a major public health concern characterized by compulsive substance use despite adverse consequences. While contemporary models emphasize biological, psychological, and environmental contributors, stress- and reward-related systems are often examined in isolation. This review integrates these systems within an evolutionary mismatch framework to examine how chronic stress exposure and repeated substance use increase vulnerability to addiction. Stress and reward systems are evolutionarily conserved but may become chronically dysregulated under modern conditions characterized by persistent psychosocial stressors and highly potent rewarding stimuli. This is associated with converging neuroadaptations across stress and reward circuitry, resulting in altered affective …

Effects Of Volatile Organic Compounds Produced By Temperature-Adapted Microbes On Duckweed Growth, Phaedra Yael Stemp

Honors Theses and Capstones

As host-associated microbes adapt to their abiotic environment, these adaptations can affect their host species as well. Previous research showed that varying temperatures and volatile organic compound (VOC) production can affect microbial benefits to hosts. This experiment analyzed how 27 microbes pre-adapted to different temperature conditions affected growth of their host, common duckweed plants, comparing effects of direct contact with microbes, effects of microbe VOCs alone, or both. Each microbe was pre-adapted to one of three temperature regimes: “Northern” at 28 °C, “Southern” at 33 °C, and “Extreme” at 36 °C. We then grew duckweeds in I-plates with each microbe …

Examining The Effectiveness Of Housing First Models On Transitional-Aged Youth Experiencing Homelessness: A Systematized Review, Cadyn Golisano

Honors Theses and Capstones

Abstract

Purpose: The purpose of this review is to examine the outcomes of Housing First (HF) programs or models for transitional-age youth (TAY) experiencing homelessness. Specifically, this review aims to synthesize existing evidence on how Housing First influences housing stability and over-all wellbeing for young adults ages 18-25. By evaluating the effectiveness of these programs within this specific population, the review seeks to identify key benefits, limitations, and gaps in the current literature to inform future practice, policy, and research. The following research question was utilized to guide this paper: How do Housing First principals and interventions impact housing stability …

Does Volunteering Give An Extra Health Boost? Volunteering And Hypertension Risk Among Insured And Uninsured U.S. Adults In Late Midlife, Byeongju Ryu, Seoyoun Kim, Koichiro Shiba, Cal J. Halvorsen

Brown School Faculty Publications

Introduction: Hypertension is a major predictor of cardiovascular disease, a leading cause of death in the U.S. Growing evidence suggests that formal volunteering in later life may reduce hypertension risk; however, it remains unclear whether these benefits extend to adults in late midlife and whether they differ by health insurance status.

Methods: This prospective cohort study analyzed data from the 2012–2018 Health and Retirement Study. The analytic sample included 4,169 respondents between the ages of 50 and 64. Because blood pressure was measured in half the sample in alternating waves, data were pooled across waves. To address selection into volunteering, …