Digital Commons Network^™

How Educational Leaders At A Type C International School In China Understand Educational Leadership, Peter Pagett

Theses: Doctorates and Masters

This study examined how educational leaders at a Type C international school in China understand educational leadership. The extensive knowledge on educational leaders identifies many important facets of this phenomenon, such as the importance of leaders focussing on mission and vision and building relationships. Current understanding also highlights the role of personal identity in influencing a leaders’ work and understandings. However, literature on educational leadership in the context of international schools is scant. Given the challenges specific to international education such as culture shock, transience and isolation there is a need to conduct more research into these types of schools. …

Hypoxic Stem Cells From Apical Papilla-Derived Exosomes Enhance Dental Pulp Stem Cells Migration And Differentiation Via Mitochondrial Activation, Deyan Yuan, Rui Tao, Bi Yin, Meng Gu

Journal of Dental Sciences

Background/purpose Stem cells from apical papilla (SCAPs) and dental pulp stem cells (DPSCs) play critical roles in dental tissue regeneration. Although intercellular communication through exosomes is known to influence stem cell regulation, the effects of exosomes derived from hypoxic SCAPs on the migration and odontogenic differentiation of DPSCs have not been elucidated. This study aimed to investigate SCAPs derived exosomes mediated modulation of DPSCs biological functions under hypoxic conditions. Materials and methods Exosomes were obtained from SCAPs cultured under normoxic or hypoxic conditions. DPSCs were treated with these exosomes, and their migration capacity was evaluated using scratch and transwell assays. …

A Scientometric And Comparative Study Of Rhabdomyosarcoma Research By Pediatricians And Stomatologists, Wenke Chen, Hui Li, Zhenhu Ren, Chongfang Zhang

Journal of Dental Sciences

Background/purpose Rhabdomyosarcoma (RMS) frequently affects pediatric patients and common occurs in the head and neck region. The purpose of this study was to compare the scientometric characteristics of RMS publications by pediatricians and stomatologists. Materials and methods All the papers on RMS were comprehensively retrieved from the Scopus database, and divided into pediatricians and stomatologists groups. Results There were 2211 and 234 papers on RMS were published by rheumatologists and stomatologists, respectively. The total citation count was 63,868 and the h index was 111 for RMS publications by pediatricians, while the respective values for stomatologists were 2952 and 29. The …

Synergistic Effects Of Biodegradable Magnesium Alloy And Erythromycin On Osteogenic Activity, Kridtapat Sirisereephap, Kitipong Pasanaphong, Thanaphum Osathanon, Patcharapit Promoppatum, Tomoki Maekawa, Viritpon Srimaneepong, Meircurius Dwi Condro Surboyo, Kamolporn Wattanasirmkit

Journal of Dental Sciences

Background/purpose: Biodegradable magnesium (Mg)–based alloys are emerging as promising alternatives to non-resorbable titanium for bone regeneration because of their favorable mechanical properties and biodegradability. However, the interaction between Mg alloys and immunomodulatory agents in promoting osteogenesis remains poorly understood. This study aimed to evaluate the osteogenic effects of an Mg alloy on pre-osteoblasts and to investigate whether erythromycin enhances Mg-induced osteogenic differentiation through regulation of developmental endothelial locus-1 (DEL-1).

Materials and methods: WE43 Mg alloy disks were immersed in culture medium to produce Mg alloy-conditioned medium at concentrations of 25%, 50%, 75%, and 100%. MC3T3-E1 cells were treated with conditioned …

Integrated Analysis Of Single-Cell And Bulk Rna-Sequence Data Reveal Plasma Dendritic Cell-Related Diagnostic Model For Sjögren's Syndrome Based On Machine Learning,, Jinhao Zhang, Chunye Zhang

Journal of Dental Sciences

No abstract provided.

Risk Of Pneumonia And Mortality After Routine Dental Scaling In Patients With Moderate-To-Severe Cerebral Palsy: A Nationwide Cohort Study, Li-Wei Ou-Yang, Ya-Ting Chang

Journal of Dental Sciences

No abstract provided.

A Visualized Ai-Assisted Framework For Pre-Surgical Evaluation Of Implant Pathways On Periapical Radiographs, Yuan-Jin Lin, Chiung-An Chen

Journal of Dental Sciences

No abstract provided.

Sleep Restriction Exacerbates Pulpal Inflammation And Impairs Tissue Repair Following Dental Pulp Capping: An In Vivo Animal Study, Siqi Huang, Qian Wang, Ziyu Chen, Guomiao Zhang, Ying Zheng

Journal of Dental Sciences

As a fundamental physiological process, sleep is essential for maintaining systemic homeostasis. Although sleep restriction (SR) has been shown to trigger a systemic inflammatory response, its specific impact on local pulpal inflammation remains poorly understood. In this preliminary study, we investigated the effects of SR on the inflammatory response and reparative capacity of dental pulp in a rat model. Immunohistochemistry and western blotting revealed that, even in intact pulp tissue, SR upregulated the expression of interleukin-6, increased the infiltration of neutrophils, and activated the nuclear factor-kappa B signaling pathway. Subsequent investigations demonstrated that following dental pulp capping, SR provoked an …

Herbal Medicine For Oral Ulcer Treatment: Mechanisms, Efficacy, And Therapeutic Potential, Shinn-Zong Lin, Tsung-Hsien Chuang, Chih-Yang Huang, Tsung-Jung Ho, Yi-Pang Lee

Journal of Dental Sciences

Oral ulcers are common inflammatory lesions of the oral mucosa that significantly affect patients’ quality of life through pain, eating difficulties, and psychological stress. Their development is multifactorial, involving mechanical trauma, infection, nutritional deficiencies, immune dysregulation, and oxidative stress. Conventional treatments including antiseptics, corticosteroids, and immunomodulators, provide symptomatic relief but are often limited by side effects, recurrence, and poor patient adherence. Increasing interest has therefore focused on herbal medicines as complementary or alternative therapies. Numerous single herbs such as Aloe vera, licorice, curcumin, chamomile, berberine, neem, sage, myrrh, and guava and traditional formulations have demonstrated anti-inflammatory, antioxidant, immunomodulatory, antimicrobial, and …

The Bridge To Practice: A Regulatory Analysis Of Pre-Licensure Dental Training In Taiwan, Wei-Chia Su, Hsin-Hu Chen, Ching-Yu Yen, Hsun-Yu Liu, Yuan-Der Huang, Jian-Hong Yu

Journal of Dental Sciences

Background/purpose: Pre-licensure dental clinical training in Taiwan is commonly viewed as an educational issue, yet it is also shaped by regulation. Eligibility for the dentist licensing examination still requires graduation, completion of internship, and possession of a diploma, whereas lawful practice requires separate practice registration and a practice license. This study examined whether the current training framework is aligned with the legal status and clinical responsibility assigned to dental students.

Materials and methods: A qualitative regulatory analysis was conducted using current official legal and policy documents in Taiwan, including the Physicians Act, the Medical Care Act, staged examination rules, the …

Very Early Interceptive Management Of Class Iii Malocclusion In Primary Dentition Using A Prefabricated Functional Education Appliance: Preliminary Clinical Observations, Thi Ngoc Anh Do, Thi Huong Le, I-Ta Lee, Tong-Hsien Chow, Pao-Chang Chiang, Thi Thuy Tien Vo

Journal of Dental Sciences

Background/purpose: Class III malocclusion with anterior crossbite in primary dentition may progress and complicate future orthodontic treatment. This short communication presents preliminary clinical observations of very early interception using a prefabricated functional education appliance.

Materials and methods: Three children aged 4 to 6 years with dental, functional, or mild skeletal class III malocclusion were treated using a prefabricated removable functional education appliance worn at night, with regular follow-up.

Results: In the dental class III case, anterior crossbite was corrected within 9 months and remained stable at the 2-year follow-up. In the functional class III case, anterior crossbite and mandibular shift …

Digital Impression Workflows And Mucosal Considerations In Removable Complete Dentures, Fu-Chuan Tsai, Hsin-Hua Chou, Takashi Saito, Wei-Chun Lin

Journal of Dental Sciences

No abstract provided.

Characteristics Of Cerebral Palsy In The Midwestern Us, Susie Kim, Kelsey Steffen, Lauren Gottschalk-Henneberry, Jennifer Miros, Amy Robichaux-Viehoever, Karen Taca, Bhooma R Aravamuthan

2020-Current year OA Pubs

OBJECTIVE: Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.

METHODS: We integrated caregiver and clinician-facing standardized data entry into routine clinical care at a tertiary care CP center (https://bit.ly/CP-Intake-Methodology). We extracted this data for people with an ICD10 diagnosis of CP seen between March 22, 2023 and December 28, 2023 and used it to describe CP characteristics and determine factors affecting the …

Novel Insights Into Early Alzheimer's Disease: Quantitative Gradient Recalled Echo Mri Reveals Preatrophic Neuronal And Myelin Injury Concurrent With Emerging Amyloid Pathology, Satya V V N Kothapalli, Tammie L S Benzinger, Randall J Bateman, Melody Li, Cihat Eldeniz, John C Morris, Dmitriy A Yablonskiy

2020-Current year OA Pubs

BACKGROUND: Brain amyloid accumulation is considered an early sign of Alzheimer's disease (AD) pathology, appearing decades before manifestation of clinical symptoms. However, very little is known about neurodegeneration during this early AD stage. Herein we use quantitative gradient recalled echo (qGRE) magnetic resonance imaging (MRI) to reveal preatrophic microstructural neuronal and myelin damage concurrent with amyloid pathology.

METHODS: qGRE MRI and positron emission tomography (PET) amyloid [

RESULTS: qGRE detected significantly lower gray matter neuronal density and white matter myelination in the group of participants with amyloid level below the conventional amyloid-positive threshold (mean cortical standardized uptake value ratio of …

Biological Aging Acceleration In Major Depressive Disorder: A Multi-Omics Analysis, Breno Satler Diniz, Shangshu Zhao, Gabin Drouard, Eero Vuoksimaa, Miina Ollikainen, Eric J Lenze, Ming Xu, Richard H Fortinsky, George A Kuchel, Jaakko Kaprio, Chia-Ling Kuo

2020-Current year OA Pubs

Major depressive disorder (MDD) is linked to a higher risk of premature aging, but the mechanisms underlying this association remain unclear. Using data from two population cohorts (UK Biobank and Finnish Twin Cohort), we evaluate the relationship between systemic and organ-specific proteomic and epigenetic aging acceleration and MDD. A lifetime history of MDD was associated with accelerated proteomic aging at both systemic and organ-specific levels-including the brain-in both cohorts, with stronger associations than those observed with systemic epigenetic aging. Systemic and brain-specific proteomic aging acceleration were linked to higher risks of incident MDD and a greater risk of Alzheimer's disease, …

Alzheimer's Disease Stage 1 And 2: Biology, Diagnostics, And Treatment, Suzanne E. Schindler, Sarah M. Hartz, Et Al.

2020-Current year OA Pubs

No abstract provided.

Participatory Systems Modeling In Implementation Research: Exploring Benefits, Facilitators, And Future Needs, Natalie Riva Smith, Jennifer L Cruz, Jessica Gannon, Stephanie Mazzucca-Ragan

2020-Current year OA Pubs

BACKGROUND: Implementation science increasingly uses participatory systems modeling (PSM) approaches to handle the complexity inherent to implementation science issues. To support the process of integrating PSM with implementation science, we aimed to understand and explicate the benefits, facilitators, and future needs of applying PSM to implementation research.

METHODS: We conducted semi-structured qualitative interviews with 23 researchers (n = 18) and practitioners (n = 5). We purposively sampled participants and identified additional participants through recommendations. Interviews were inductively analyzed. Key concepts were identified via iterative description, comparison, and conceptualization.

RESULTS: Engagement with people in the system was typically focused in earlier …

Concordance Of Fluorescence In Situ Hybridization, Whole-Exome Sequencing, And Chromosomal Microarray For Evaluating High-Risk Molecular Features In Meningiomas, Brenndan Crumley, Emilie Russler-Germain, Sonika Dahiya

2020-Current year OA Pubs

BACKGROUND: Meningiomas are the most common primary intracranial tumors, classified into three WHO grades based on histologic and/or molecular criteria. cIMPACT-NOW Update 8 underscores the increasing importance of molecular testing in grading and risk stratification, noting that morphologically WHO grade 1 tumors with concurrent 1p and 22q losses demonstrate clinical behavior comparable to WHO grade 2 meningiomas. This study aimed to assess the concordance of fluorescence in situ hybridization (FISH), chromosomal microarray analysis (CMA), and whole-exome sequencing (WES) in defining the molecular risk profile of meningiomas.

METHODS: A total of 113 meningiomas were analyzed by WHO grade to assess the …

Epithelial-Mesenchymal Transition And Stress Adaptations Underlie Yttrium-90 Resistance In Liver Cancer Cell Lines, Alexander Zheleznyak, Dhanusha Duraiyan, Prasanth Thunuguntla, Jessica Camacho, Shuang Wu, Jingxia Liu, Jason D Weber, Daniel L J Thorek, Benjamin S Strnad, Ryan C Fields, Matthew A Ciorba, Christine Yoon, Valerie Blanc, Nicholas Davidson, Jessica Silva-Fisher, Christopher D Malone

2020-Current year OA Pubs

UNLABELLED: Molecular signatures predict prognosis in hepatocellular carcinoma, but their relevance to transarterial radioembolization (TARE) with yttrium-90 (90Y) is unknown. We aimed to identify baseline and treatment-induced pathways associated with response and nominate biomarkers. Ten transcriptomically diverse human liver cancer cell lines were exposed to escalating activities of glass 90Y microspheres for 10 days. Normalized AUC values quantified sensitivity. Whole-transcriptome RNA sequencing at baseline and after treatment was analyzed with elastic net regression and gene set enrichment. Findings were corroborated by qRT-qPCR and exploratory analysis of pretreatment tumor samples from patients undergoing TARE. Liver cancer cell line responses to 90Y …

Airway Management In Emergency Department Thoracotomy: A Narrative Review, Aaron J Lacy, Adam Liebendorfer, Sarah M Guess, Rami S Al-Aref, Anthony P Kronfli, Rachel E Armstrong, Amelia W Maiga, Alexander Bracey, Ryan N Barnicle

2020-Current year OA Pubs

INTRODUCTION: Emergency department thoracotomy (EDT) is a high-risk, life-saving intervention for patients in traumatic cardiac arrest. A critical component of EDT is airway management, typically performed by emergency physicians, yet formal guidance regarding optimal strategies remains limited. Airway management in this setting is uniquely complex due to concurrent anatomic injury, physiologic instability, and the procedural demands of thoracotomy.

DISCUSSION: Endotracheal intubation (ETI) during EDT presents multiple challenges. Anatomic difficulties may arise from facial or cervical trauma, restricted positioning, and the presence of cervical collars. Cognitive load is heightened by the chaotic, multidisciplinary environment, requiring strategies such as pre-briefing, checklists, and …

A Single-Cell Atlas Characterizes Dysregulation Of The Bone Marrow Immune Microenvironment Associated With Outcomes In Multiple Myeloma, William C Pilcher, Lijun Yao, Yizhe Song, Kazuhito Sato, Julia T Wang, Reyka G Jayasinghe, Jennifer A Foltz, Mark A Fiala, Chiang I-Ling, Julie Fortier, Michael Slade, Stephen T Oh, Michael P Rettig, John F Dipersio, Shaji Kumar, Ravi Vij, Li Ding, Et Al.

2020-Current year OA Pubs

Multiple myeloma (MM) remains incurable despite advances in treatment options. Although tumor subtypes and specific DNA abnormalities are linked to worse prognosis, the impact of immune dysfunction on disease emergence and/or treatment sensitivity remains unclear. We developed an Immune Atlas of MM by generating profiles of 1,397,272 single cells from the bone marrow (BM) of 337 newly diagnosed participants and characterized immune and hematopoietic cell populations. Cytogenetic risk-based analysis revealed heterogeneous associations with T cells of BM, with 17p13 deletion showing distinct enrichment of a type 1 interferon signature. The disease progression-based analysis revealed the presence of a proinflammatory immune …

Assessment Of Carbon Capture Potential In Rubber Plantations Via Landsat 9 Imagery Analysis, Ade Fitria, Rahmawaty Rahmawaty, Razali Razali, Jamin Saputra, Seca Gandaseca

Baghdad Science Journal

Indonesia is a significant greenhouse gas (GHG) emitter, contributing 12.3% of carbon dioxide (CO₂) of total emissions. Carbon dioxide (CO₂), a major GHG, is increasing in the Earth’s atmosphere. The CO₂ absorption can be increased through rubber plantations because rubber plants, such as forest plants, can process CO₂ as a carbon source for photosynthesis. This research aims to analyze carbon uptake in relation to tree density, biomass of rubber vegetation, and soil organic carbon (SOC) content, as well as to map the distribution of carbon potential using remote sensing. This research was conducted in …