Digital Commons Network^™

Investigating Metabolic Heterogeneity In Engineered Isogenic Microorganisms, Xinyue Mu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Engineered microorganisms play an increasingly important role in the sustainable production of fuels, bioplastics, and other valuable biomaterials. Successful industrial deployment depends on maximizing product titers and ensuring process robustness at large scale. However, one of the major obstacles is non-genetic cell-to-cell heterogeneity arising from stochastic intracellular processes. Such heterogeneity can result in subpopulations that divert substrates toward growth rather than product biosynthesis, ultimately reducing yield and contributing to batch-to-batch inconsistency. To better understand the mechanisms by which cell-to-cell variation emerges, propagates, and impacts bioproduction, this dissertation investigated how intracellular energetic dynamics and stochastic biosynthetic noise contributed to metabolic heterogeneity …

Learning From Images And Text (Clinical) Data: Toward Putting Ai In Radiology Workflows, Pan Xiao

McKelvey School of Engineering Graduate Student Theses & Dissertations

The rapid growth of medical imaging data highlights the need for intelligent systems that can understand both radiological language and image content. This dissertation presents two complementary research directions that advance machine learning in radiology through large-scale natural language understanding and unsupervised image representation learning. The first part develops and benchmarks machine learning models for identifying follow-up recommendations in radiology reports—a task essential for improving patient care and reducing missed follow-ups. Using 49,769 reports across multiple modalities and three institutional datasets, along with external and temporal test sets, thirty-two classification methods were systematically evaluated on both findings and impression sections. …

The Effects Of Kyphosis Angle Reduction On Balance, Fall Risk, And Quality Of Life, Karen Buckley

Doctorate in Kinesiology

Purpose: Hyperkyphosis is an abnormal sagittal plane curvature of the spine. The kyphosis angle (KA) increases as age increases, leading to fractures, falls, and potential mortality. This study aims to determine if reducing the KA improves balance, stability, and quality of life in the elderly. Methods: Thirty-one participants, including males and females, aged 63.03±9.61, participated in this study. This study used the kyphosis index (KI), which is a measurement of the distance between the occiput and the wall. Elderly individuals with an occiput wall distance (OWD) of > 4cm participated in this study. The Ferrans and Powers Quality of Life questionnaire, …

Fort Hays State University Tiger Weekly, December 19, 2025, University Relations

Tiger Weekly Newsletters

No abstract provided.

Consciousness Studies In Community: Allan Leslie Combs’S Enduring Vision, Debby Flickinger Phd, Rebecca A. Damien Phd

Journal of Conscious Evolution

Consciousness studies can be found in many different disciplines. Allan Leslie Combs held an inclusive view of consciousness that was not limited to any one branch, and he inspired us to explore consciousness through many doorways. Together the authors share narratives about teaching and learning with Combs while reviewing key areas shaped by his legacy, including gatherings, archetypes, psychology, and synchronicity. Our shared intention is to honor Leslie’s legacy through a narrative that comes from the heart as well as the mind.

Keywords: consciousness studies, gatherings, archetypes, synchronicity, Allan Leslie Combs

Single-Nucleus Multiomics Reveals The Disrupted Regulatory Programs In Three Brain Regions Of Sporadic Early-Onset Alzheimer’S Disease, Andi Liu, Citu Citu, Nitesh Enduru, Xian Chen, Chia-Hao Tung, Tirthankar Sinha, Sofia E Sepulveda, Astrid M Manuel, Damian Gorski, Brisa S Fernandes, Meifang Yu, Paul E Schulz, Lukas M Simon, Claudio Soto, Zhongming Zhao

Faculty, Staff and Student Publications

Sporadic early-onset Alzheimer’s disease (sEOAD) represents a substantial but less-studied subtype of Alzheimer’s disease (AD). Here, we generated a single-nucleus multiome atlas derived from the postmortem prefrontal cortex, entorhinal cortex, and hippocampus of nine individuals with or without sEOAD. Comprehensive analyses were conducted to delineate cell type–specific transcriptomic changes and linked candidate cis-regulatory elements (cCREs) across brain regions. We prioritized eight conservative transcription factors in glial cells in multiple brain regions, including RFX4 in astrocytes and IKZF1 in microglia, which are implicated in regulating sEOAD-associated genes. Moreover, we identified the top 25 altered intercellular signaling between glial cells …

Artificial Intelligence And Consumer Trust, Privacy, And Protection On Digital Platforms, Alheri Gajere Adams

Walden Dissertations and Doctoral Studies

Academic scholars have researched the impact of artificial intelligence (AI) on privacy, trust, and data governance; however, substantial gaps remain—particularly regarding how AI influences consumer trust and privacy among Texas consumers subscribed to digital platforms. The purpose of this generic qualitative study was to explore how Texas consumers experience and perceive online platforms for personal and private use regarding online data privacy and trust, underscoring the gap in prior research on how state-level consumer protection laws, such as the Texas Deceptive Trade Practices Act (DTPA), address concerns relative to data trust, privacy, and digital protection. The conceptual framework that guided …

The Impact Of Patient-Generated Health Data From Mobile Health Technologies On Health Care Management And Clinical Decision-Making: Narrative Scoping Review, Ava Keeling, John Downey, Matthew Halkes, Yinghui Wei

School of Nursing and Midwifery

Background: Long-term health conditions and multimorbidity are increasing globally, placing an unsustainable pressure on health care systems. Mobile health (mHealth) technologies enable the collection of patient-generated health data outside clinical settings, offering the potential to support personalized care and inform clinical decision-making. However, the ways in which mHealth patient data are being used in clinical practice remain unclear. Objective: This study aimed to map and synthesize the existing literature on how patient-generated mHealth data are reportedly being used and influencing clinical decision-making for adults with long-term conditions in an outpatient care setting. Methods: A narrative scoping review was conducted on …

Leveraging Transcranial Ultrasound Stimulation To Enhance Self-Regulation In Emotion And Sleep, Suraya Dunsford, Mica Komarnyckyj, Elsa Fouragnan

School of Psychology

This Perspective article discusses the emerging potential of transcranial ultrasound stimulation (TUS) as a non-invasive neuromodulatory technique for enhancing self-regulatory processes, particularly emotion and sleep regulation, in healthy individuals. Offering high spatial precision and the ability to target both cortical and deep brain regions, TUS uses focused ultrasound waves to induce acute and delayed effects on brain activity. We propose that combining TUS with neurofeedback methods and/or specific cognitive training exercises may capitalise on these neuroplastic effects, thereby augmenting and prolonging their impact to support lasting improvements in self-regulation. We focus on the domains of sleep and emotion regulation, where …

Exploring The Medicinal Properties Of Indigenous Plants Within An Enabling Program: Bridging The Gap Between School, Aboriginal And Torres Strait Islander Knowledge And Science, Sharon L. Gough, Julie Sartori, Angela Jones

Research outputs 2022 to 2026

In 2021, less than half of Australian universities considered Indigenous perspectives in curriculum development, with only 15% ensuring Indigenous content in all courses. Literature acknowledges that a strengths-based approach to the inclusion of Aboriginal and Torres Strait Islander knowledge and perspectives, enhances representation and decolonises curriculum. In 2020, Noongar elder Vivienne Hansen, and John Horsfall created Noongar Bush Medicine, detailing the medicinal use of Indigenous plants. Yeshi, Turpin, Jamtsho, and Wangchuk noted that many Aboriginal and Torres Strait Islander communities use native plants for health purposes. However, there is limited data on the therapeutic efficacy of these plants. In 2024, …

A System And Method For Validating Payee Identity In Unified Payments Interface (Upi) Based Payment Transactions, Alok Roy

Defensive Publications Series

The present disclosure relates to a system and method for validating payee identity in unified payments interface (UPI) based payment transactions. The method prevents misrouted payments in a digital payment environment, specifically addresses risks associated with mobile number reassignment. The system includes a mobile number re-authentication module designed to detect re-linking of mobile numbers to new accounts and an identity-change ledger that records historical mappings of mobile numbers to account holder identities. The method initiates by receiving a mobile number entry from a payor, performing a validation step that cross-references the entered number against the identity-change ledger, and generating a …

The Aesthetics Of Endings, Mary Imbong

Budhi: A Journal of Ideas and Culture

What does it mean for an experience to end? Guided by this question, I offer an interpretation of John Dewey’s notion of endings in Art as Experience and propose a perspective on the role of endings in aesthetic experiences. We often instinctively view endings as the final note in a sequence of events—disconnected from the moments that come before it. Dewey, however, sees them not as an isolated fragment but as part of the unity of an experience. His themes of doing and undergoing, as well as unity and wholeness, challenge conventional views of experience and encourage reflection on how …

Socrates And Early Buddhist Medical Ethics: Foundations Of Moral Reasoning In The Care Of Body And Mind, Chandima Gangodawila

Budhi: A Journal of Ideas and Culture

While Buddhist traditions articulate a parallel moral vision in the early discourses of the Pāli Canon, Western traditions usually locate the roots of ethical reasoning in Socratic inquiry. Especially in their approaches to bodily care, spiritual well - being, and moral responsibility, this article contends that both Socratic and Early Buddhist ideas converge on fundamental principles in medical ethics. Through a comparative textual and philosophical study, the paper examines how Socratic dialectics and the Buddha's diagnostic approach to dissatisfa ction/ suffering (dukkha) both produce frameworks for ethical healthcare anchored in the development of virtue, wisdom, and care for the integrity …

Lessons Learned: Paul Tucker, Salil Gupta

Journal of Financial Crises

After joining the Bank of England (BoE) in 1980, Sir Paul Tucker held a number of positions of increasing responsibility including serving as a member of several key committees. Tucker played a crucial role in the BoE’s response to the Global Financial Crisis (GFC) as director for markets, through March 2009, then as deputy governor of the bank until November 2013. Post-crisis, he has been instrumental in constructing the international regulatory framework on financial stability. From 2016 to 2021, Tucker also chaired the Systemic Risk Council.

Currently, Tucker is a research fellow at Harvard Kennedy School, Mossavar-Rahmani Center for Business …

Central Bank Crisis Interventions: A Review Of The Recent Literature On Potential Costs, Patrick Aldridge, David A. Cimon, Rishi Vala

Journal of Financial Crises

Central banks may engage in large-scale lending and asset purchases to stabilize financial markets and implement monetary policy during crises. The ability of these actions to restore financial market functioning is well documented; however, they come with costs. We provide a literature review of the costs associated with these post-Global Financial Crisis central bank actions, without commenting on the net benefits they provide. We find support for the premise that crisis actions may negatively impact market liquidity, distort asset prices, increase rent-seeking and inefficient uses of the liquidity provided by the central bank, create international spillovers, and create distortions in …

Proposing Augmented Reality Game-Based Learning For Higher Education, Anna C. Zaldivar

The Scholarship Without Borders Journal

Simulating the role of an instructional technologist, negotiation takes place to implement the AR technology for use in a higher education institution. There are arguments both for and against the use of augmented reality for higher education. Overall, examining and highlighting these arguments to make an important decision that will shape learners' future. Using BATNA and examining arguments during the negotiation process.

Understanding Generation Z Polarization: Findings From A Preliminary Replication Study, Liane Weintraub

The Scholarship Without Borders Journal

Amid rising polarization and declining trust in democratic institutions, Generation Z (Gen Z) faces unique challenges in navigating civic discourse. This study presents comparative findings from two survey cohorts (2023, n = 56; 2025, n = 25) examining Gen Z students’ political identity, discourse habits, interpersonal trust, and civic attitudes. Framed by Social Identity Theory (SIT), Cultural Intelligence (CQ), and discourse theory, the study explores how ideological difference and identity signaling shape students’ willingness to engage across divides. Findings indicate continuity in partisan skepticism and discourse openness, but also growing fatigue, reduced trust, and ambivalence toward equity. While affective polarization …

Marooned: A Western Frontier Dismal Swamp Narrative, Professor Meya E. Hargett

The Scholarship Without Borders Journal

Marooned: A Western Frontier Dismal Swamp Narrative centers the erased figure of Samuel Mars, a lost Black station master whose movements through the Great Dismal Swamp have been excluded from dominant Underground Railroad cartographies. Here, the term “Marooned” refers not to abandonment, but to the maroon geographies of Black and Indigenous resistance encoded in land, lineage, and fugitive infrastructure.

Guided by Diasporic Maroon Memory Theory, Lineage as Method, and the Maroon Geographies Framework, this research reconstructs Mars’s trajectory through oral testimony, spatial patterning, and ancestral land memory. Rather than casting the Dismal Swamp merely as a site of refuge, this …

Extending The Emotional And Multiple Intelligence Theories: Integrating Cultural And Spiritual Intelligence Constructs To Fill Research Gaps, Kimberly J. Mcdonald

The Scholarship Without Borders Journal

This proposed mixed-methods convergent research study aims to explore extending the Emotional Intelligence (EI) and Multiple Intelligences Theories by integrating Spiritual Intelligence (SI) and Cultural Intelligence (CQ) constructs. The goal is to explore the interconnectedness of these intelligences to bridge existing research gaps concerning leadership, EI, SI, and CQ. By employing both quantitative and qualitative data collection methods from organizational leaders, this study seeks to develop a more comprehensive and holistic understanding of leadership efficacy across various organizational contexts. The anticipated outcomes aim to contribute to the body of knowledge and potentially impact leadership development in business, education, and other …

Article Title: Deconstructing Power And Gender: A Foucauldian Discourse Analysis Of Biopolitics, Necropolitics, And Sexual Scripts In Feminicide In Puerto Rico., Migdalia Marrero-Lafontaine

The Scholarship Without Borders Journal

Feminicide and gender violence cases in the last several decades in Puerto Rico have continuously increased, suggesting that this problem becomes worse as time passes. This study, therefore, focuses on identifying actionable insights that paint a picture of the impact it has on women over the age of 18 in Puerto Rico. In order to achieve this objective, the study relies on a strong theoretical framework that is made up of Foucauldian discourse analysis, necropolitics, and sexual scripts theories. One of the core findings of this research is that Puerto Rico’s colonial history and cultural norms sustain a cycle of …

The Detrimental Impact Of Early Childhood Exposure To Pornography, Leica Marie Estomo

The Scholarship Without Borders Journal

As pornography continues to become more easily and readily accessible, children are at higher risk of viewing it. This work aims to investigate the destructive impact of premature exposure to pornography, and the negative perceptions of sex and decision-making towards it as a result. The operational definition used defines “early exposure” as prepubescents (children of elementary-grade school ages) viewing explicit material through involuntary and accidental initial engagement, and “decision-making” as moral agency and choice of response and action. The populations searched focused more on American culture and its lens on sex and pornography, with the incorporation of other cultural frameworks …

Abc Pharmaceutical Company Change Model: Implementing J.P. Kotter's 8-Step And Adkar Change Models For Ethical Alignment, Shelbi B. Chandler, Amalfi Gayosso, Alison Lawton, Ali Holness-Roland

The Scholarship Without Borders Journal

In this paper, we use the pseudonym ABC Pharmaceuticals (ABC) to refer to the company under examination, GlaxoSmithKline (GSK). ABC Pharmaceutical (ABC) must assess, adapt, and change to ensure regulatory compliance, maintain and attract employees, and remain competitive. ABC has a history of erroneous practices and is at risk internally with employees, and externally with regulators and the public sectors. The authors applied J.P. Kotter’s (1996) 8-step and the ADKAR (Hiatt, 2006) models for change management. J.P. Kotter’s top-down model addresses leadership’s role in creating a compelling vision aligned with its actions, and the ADKAR bottom-up model assesses employees’ readiness …

Review Of Acts Of Conscience: Christian Nonviolence And Modem American Democracy, Dan Mckanan

Communal Societies

No abstract provided.

The Ongoing Shaker Covenant, Stephen J. Paterwic

Communal Societies

No abstract provided.

Seeing The Faces, Laura Kohl Johnston

Communal Societies

No abstract provided.

Internet Technology's Impact On Intentional Communities: A Case Study Of Acorn Community, Jade Aguilar

Communal Societies

No abstract provided.

Marie Ogden And The Home Of Truth: A Millennial Prophet And The Life And Decline Of Her Community, Bradley C. Whitsel

Communal Societies

No abstract provided.

New Harmony, The Owen Brothers, And The Origin Of The Smithsonian, Lucy Jayne Kamau

Communal Societies

No abstract provided.

Front Matter

Communal Societies

No abstract provided.

The Communal Wanderings Of August Jacobi, Peter Hoehnle

Communal Societies

No abstract provided.