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2026

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Reclaimed Futures: Cultivating Design Thinking Through Waste Mapping And Material Reuse, Laura Del Pino, Darion Washington Feb 2026

Reclaimed Futures: Cultivating Design Thinking Through Waste Mapping And Material Reuse, Laura Del Pino, Darion Washington

SoTL Commons Conference

No abstract provided.


Impella 5.5 Versus Heartmate 3 In Left Ventricular Unloading, Hannah Frederick, Douglas Tran, Erik Sorenson, H. Todd Massey, Albert Hicks, Manjula Ananthram, Bartley P. Griffith, Aakash Shah Feb 2026

Impella 5.5 Versus Heartmate 3 In Left Ventricular Unloading, Hannah Frederick, Douglas Tran, Erik Sorenson, H. Todd Massey, Albert Hicks, Manjula Ananthram, Bartley P. Griffith, Aakash Shah

The VAD Journal

The Impella 5.5 (Abiomed) is increasingly used as a bridge to durable left ventricular assist device (LVAD) implantation in advanced heart failure, yet most studies focus on survival and transition success rather than left ventricular (LV) unloading or valvular effects. This study addresses this gap by comparing Impella 5.5 and HeartMate 3 (HM3, Abbott) in terms of unloading and cardiac support at similar flow rates. We conducted a retrospective study of nine patients who received Impella 5.5 before HM3 implantation. The primary outcome was the degree of LV unloading, as assessed by changes in left ventricular end-diastolic diameter (LVEDD). There …


Improving The Uv Resistance And Service Life Of Polystyrene-Based Building Materials Via Low-Concentration Metal Complex Modifiers, Dina S. Ahmed, Marwa Fadhil, Raghda Alsayed, Mohammed Kadhom, Muna Bufaroosha, Amani Husain, Thura Alyasiri, Hanan Ibraheem, Alaa A. Rashad, Bassam M. Abood, Riyadh Noaman, Ahmed Ahmed, Ruqaya Raad, Ala'a Shaker, Abeer Erfan, Hassan Hashim, Saba Hamza, Rahimi M. Yusop, Emad Yousif Feb 2026

Improving The Uv Resistance And Service Life Of Polystyrene-Based Building Materials Via Low-Concentration Metal Complex Modifiers, Dina S. Ahmed, Marwa Fadhil, Raghda Alsayed, Mohammed Kadhom, Muna Bufaroosha, Amani Husain, Thura Alyasiri, Hanan Ibraheem, Alaa A. Rashad, Bassam M. Abood, Riyadh Noaman, Ahmed Ahmed, Ruqaya Raad, Ala'a Shaker, Abeer Erfan, Hassan Hashim, Saba Hamza, Rahimi M. Yusop, Emad Yousif

AUIQ Technical Engineering Science

PS is highly susceptible to UV-induced photodegradation, which results in deterioration of its mechanical and aesthetic properties. In the present study, four novel and highly aromatic levofloxacin metal complexes, synthesized from Zn, Sn, Cu, and Ni, were investigated as low-concentration (0.5% w/w) photostabilizer additives for PS. Composite films were prepared by solution casting and subjected to accelerated UV irradiation up to 300 hours. Photostabilizing performance was systematically followed by monitoring changes in the carbonyl index via FT-IR spectroscopy, mass loss measurements, and surface morphology analyses using SEM and AFM. Results showed that all levofloxacin metal complexes had a pronounced inhibition …


February 26, 2026, James Madison University Feb 2026

February 26, 2026, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.


Dairy And Food Science Student Newsletter, February 26, 2026, Department Of Dairy And Food Science Feb 2026

Dairy And Food Science Student Newsletter, February 26, 2026, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.


Exploring Molecular And Morphological Diversity Of Ostracoda: A Combined Approach Based On Coi Sequences And Morphological Characters, Serdar Di̇nç, Serap Mutun, Okan Külköylüoğlu Feb 2026

Exploring Molecular And Morphological Diversity Of Ostracoda: A Combined Approach Based On Coi Sequences And Morphological Characters, Serdar Di̇nç, Serap Mutun, Okan Külköylüoğlu

Turkish Journal of Zoology

Ostracods are diminutive aquatic invertebrates with a broad geographical distribution  across a diverse range of aquatic habitats, including lentic and lotic freshwater  environments as well as marine waters. Due to their sensitivity to environmental  changes, ostracods are valuable tools in biodiversity monitoring, providing a link to  past, present, and future ecological conditions. Despite the significance of classical  taxonomic studies in species identification, molecular approaches remain  underutilized in ostracod research, representing an area of potential growth for  advancing our understanding of this diverse group. Thus, molecular studies in  ostracods have the potential to greatly enhance our understanding of morphology,  ecological variation …


Spatial And Temporal Variability Of Mayfly Communities (Insecta: Ephemeroptera) In Mountainous And Semimountainous Rivers Of The Western Aegean Basin, Biljana Rimcheska, Yanka Vidinova Feb 2026

Spatial And Temporal Variability Of Mayfly Communities (Insecta: Ephemeroptera) In Mountainous And Semimountainous Rivers Of The Western Aegean Basin, Biljana Rimcheska, Yanka Vidinova

Turkish Journal of Zoology

Mayflies are among the most abundant benthic invertebrates inhabiting natural lotic  freshwater systems. Their assemblages vary with environmental, geographical, and  hydrological conditions along altitudinal gradients and under different types of  watershed disturbance. The main objective of this study was to analyze the  composition and β-diversity of mayflies across three river watersheds and to assess  how these assemblages differ among them. We collected biological and  environmental data from 38 sampling sites distributed across the three river  watersheds. We hypothesized that mayfly assemblages would vary with  environmental gradients on both spatial and temporal scales; specifically, we  expected pristine streams to exhibit higher …


Cover And Contents Feb 2026

Cover And Contents

Turkish Journal of Zoology

No abstract provided.


Towards The Assessment Of E-Flows: A Fish-Based Approach For The Tiber River Basin (Central Italy), Antonella Carosi, Francesca Lorenzoni, Fatemeh Zarei, Rachele Brustenga, Lucio Di Matteo, Daniela Valigi, Corrado Cencetti, Carlo Cardellini, Stefano Casadei, David Cappelletti, Massimo Lorenzoni Feb 2026

Towards The Assessment Of E-Flows: A Fish-Based Approach For The Tiber River Basin (Central Italy), Antonella Carosi, Francesca Lorenzoni, Fatemeh Zarei, Rachele Brustenga, Lucio Di Matteo, Daniela Valigi, Corrado Cencetti, Carlo Cardellini, Stefano Casadei, David Cappelletti, Massimo Lorenzoni

Turkish Journal of Zoology

Estimating ecological flows (EFs) in rivers is crucial for meeting the Water Framework  Directive (WFD) 2000/60/EC goals. To develop an EF model, it is  essential to use biological indicators to reliably record the impacts of human-induced  alterations on aquatic ecosystems. The adaptability of fish to annual flow variability  makes them a significant biological quality element (BQE). Consequently, using fish  as bioindicators is a powerful tool for assessing the impact of changes in the  hydrological regime on the natural communities within a river system. The new index  of the ecological status of fish communities (NISECI) is a methodology developed in  Italy …


Chlorella Vulgaris Measurements Using Full-Spectrum Goniometer For Optically Complex Inland Water Monitoring, Pinar Gürbüzer, Uğur Murat Leloğlu Feb 2026

Chlorella Vulgaris Measurements Using Full-Spectrum Goniometer For Optically Complex Inland Water Monitoring, Pinar Gürbüzer, Uğur Murat Leloğlu

Turkish Journal of Zoology

Rising environmental stressors, including climate change, nutrient loading, pollution,  and anthropogenic impacts, have made the continuous monitoring of lake water  quality increasingly essential. While in situ methods offer high precision, satellite-based remote sensing is essential for capturing large-scale, long-term changes and  accessing remote or extreme environments. To complement these approaches, we  developed a cost-effective in situ optical measurement system specifically designed  for optically complex inland waters. T he instrument enables detailed optical  characterization across scattering angles from 0° to 160° and wavelengths between  423 and 728 nm, covering both visible and near-infrared regions. Initial validation was  performed using monocultures of …


Introduction: Rethinking Circulation In Italian Film And Media, Simone Brioni Dr., Rachel Johnson, Shelleen Greene Feb 2026

Introduction: Rethinking Circulation In Italian Film And Media, Simone Brioni Dr., Rachel Johnson, Shelleen Greene

Department of English Faculty Publications

This introduction to the special issue ‘Rethinking Circulation in

Italian Film and Media’ reconsiders how Italian audiovisual culture

moves across borders – industrially, geographically, linguistically,

and digitally. By focusing on the complex dynamics of circulation,

the essays gathered here trace the evolving connections between

production and distribution, exploring how contemporary modes

of localization, translation, and platform curation shape the

visibility and cultural capital of Italian cinema in global contexts.

From streaming giants such as Netflix to curated services like

MUBI, and from film festival circuits to independent film-making

networks, the issue interrogates how transnational infrastructures

of distribution redefine what counts …


Energy Drinks Maintain High Motivational Value Even When Access Becomes Costly, Tyler Hansen Feb 2026

Energy Drinks Maintain High Motivational Value Even When Access Becomes Costly, Tyler Hansen

Research on Capitol Hill

Energy drinks are extremely popular among adolescents and young adults in the United States. These beverages contain high amounts of caffeine and sugar. Consuming energy drinks, especially in large quantities, has been shown to pose health risks.


Ant Queens Divide Tasks Among Themselves To Maximize Efficiency In Multi-Queen Colonies, Ian Brush Feb 2026

Ant Queens Divide Tasks Among Themselves To Maximize Efficiency In Multi-Queen Colonies, Ian Brush

Research on Capitol Hill

Before workers arrive, founding queens must sustain the colony on their own. In single-queen colonies, one queen performs all necessary tasks. In contrast, when several queens co-found a colony, their contributions often differ: some queens invest more in egg-laying, while others devote more effort to brood care or nest maintenance.


Oxytocin May Shape How Reward Is Perceived And Increase Self-Control, K.A. Wachtel Feb 2026

Oxytocin May Shape How Reward Is Perceived And Increase Self-Control, K.A. Wachtel

Research on Capitol Hill

Social contact, driven by oxytocin, is inherently rewarding. However, less is known about how oxytocin impacts the perception of nonsocial rewards, like food or drugs.


We Can Use Coyotes As A Model To Understand How Social Loss Alters The Brain, Rebekah Rowe Feb 2026

We Can Use Coyotes As A Model To Understand How Social Loss Alters The Brain, Rebekah Rowe

Research on Capitol Hill

While we understand some factors that increase psychological distress for grieving individuals, little is known about this biological basis.


In Conservation Efforts People Prioritize Smart, Friendly Animals, And Focus On Their Faces, Jacey Hopkin Feb 2026

In Conservation Efforts People Prioritize Smart, Friendly Animals, And Focus On Their Faces, Jacey Hopkin

Research on Capitol Hill

Conservation programs are often inefficient. They provide the public logical information in hopes they will act logically, but people's actions instead rely on their pre-held beliefs, attitudes, and biases.


Could Gene Editing Increase Chicken Resistance To Avian Influenza?, Alta Crane Feb 2026

Could Gene Editing Increase Chicken Resistance To Avian Influenza?, Alta Crane

Research on Capitol Hill

Avian Influenza is a viral infection that causes outbreaks of "bird flu," greatly affecting avian health. Influenza A virus (IAV) relies on various host factors for efficient replication. Previous studies in human cells have identified four genes as critical host factors required for IAV infection. To investigate whether similar host– virus interactions exist in avian species, we utilized gene editing systems to generate knockout fibroblast cell lines targeting those four genes and then applied these techniques to germ cells.


Accumulation Of Polyphenolic Compounds In Amelanchier × Lamarckii Fruit In Conditions Of Southwestern Slovakia, Luba Durisova, Tunde Jurikova, Monika Ondrasova, Pavol Elias Jr., Deni̇z Hazar, Jiri Mlcek Feb 2026

Accumulation Of Polyphenolic Compounds In Amelanchier × Lamarckii Fruit In Conditions Of Southwestern Slovakia, Luba Durisova, Tunde Jurikova, Monika Ondrasova, Pavol Elias Jr., Deni̇z Hazar, Jiri Mlcek

Turkish Journal of Agriculture and Forestry

In Slovakia, snowy mespilus (Amelanchier × lamarckii F. G. Schroed.) is recognized both as an ornamental plant and alesser-known fruit species, prized for its high levels of bioactive compounds, particularly polyphenols. The aim of this study was todetect the polyphenolic profile of snowy mespilus and to assess polyphenol accumulation in cells. The total polyphenol content wasdetermined by the Folin–Ciocalteu method, antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assayand the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, and individual polyphenolic compounds by the highperformanceliquid chromatography (HPLC) method. The results of analyses revealed that among the phenolic acids, chlorogenicacid was the most prevalent [44.24 …


A Free Black Farming Community In White Clay Creek Hundred, James Jones Feb 2026

A Free Black Farming Community In White Clay Creek Hundred, James Jones

History Faculty Publications

Although Delaware remained a slave state until the end of the Civil War, free Blacks were able to acquire land before that.  A small group settled along Delaware’s northern border with Chester County, even though Pennsylvania offered greater legal protection against enslavement.  This article describes what is known about the four families that settled along Hopkins Road in White Clay Creek Hundred, and the factors that affected their decision to remain in Delaware.


Pro-Environmental Behavior: Its Moderating Role On The Relationship Between Environmental Identity And Climate Change Anxiety Among Gen Z Filipinos, Marc Eric S. Reyes, Alvin Joseph D. Mapoy, Victoria Ann Louis N. Aranzanso, Francheska Ysabel A. Avera, Beatrice O. Martinez, Mariah Michaela T. Ramos, Ryan Francis O. Cayubit Feb 2026

Pro-Environmental Behavior: Its Moderating Role On The Relationship Between Environmental Identity And Climate Change Anxiety Among Gen Z Filipinos, Marc Eric S. Reyes, Alvin Joseph D. Mapoy, Victoria Ann Louis N. Aranzanso, Francheska Ysabel A. Avera, Beatrice O. Martinez, Mariah Michaela T. Ramos, Ryan Francis O. Cayubit

Makara Human Behavior Studies in Asia

Environmental identity refers to an individual’s understanding of how their environment shapes their identity and relationships. This connection may cause climate change anxiety and motivate pro-environmental behavior. Using an explanatory, cross-sectional design, we examined whether environmental identity (EI) predicts climate change anxiety (CCA) and whether pro-environmental behavior (PEB) moderates their relationship. Seven hundred sixty-one Filipinos aged 18–25 completed the Revised Environmental Identity Scale, Climate Change Anxiety Scale, and Pro-Environmental Behavior Scale. Our findings revealed a significant positive relationship between environmental identity and anxiety about climate change. However, moderation analysis indicated that environmental identity is only associated with climate change anxiety …


Chrysin Alleviates Salt Stress By Enhancing Antioxidant Enzymes, Nutrient Balance, And Phytohormone Contents In Forage Pea, Sedat Severoğlu Feb 2026

Chrysin Alleviates Salt Stress By Enhancing Antioxidant Enzymes, Nutrient Balance, And Phytohormone Contents In Forage Pea, Sedat Severoğlu

Turkish Journal of Agriculture and Forestry

This study aimed to evaluate the potential protective effects of chrysin (Chr), a flavonoid compound, on growth, biochemical,hormonal, and nutrient levels in forage pea (Pisum sativum ssp. arvense L.) seedlings under NaCl-induced salt stress. The experimentwas conducted under controlled greenhouse conditions in a completely randomized design with three different concentrations of Chr(Chr0: 0 mM, Chr1: 0.1 mM, and Chr2: 0.5 mM Chr) and three levels of salt stress (S0: 0 mM, S1: 100 mM, and S2: 200 mM NaCl),resulting in nine treatment combinations (T0: Chr0S0, T1: Chr0S1, T2: Chr0S2, T3: Chr1S0, T4: Chr1S1, T5: Chr1S2, T6: Chr2S0, T7: Chr2S1, andT8: …


Effects Of Gamma Irradiation On Antioxidant Enzyme Activities In Black Carrot Callus Under Drought Stress, Damla Turan Büyükdi̇nç, Di̇lruba Tabay Sümbül, Sheikh Mansoor Feb 2026

Effects Of Gamma Irradiation On Antioxidant Enzyme Activities In Black Carrot Callus Under Drought Stress, Damla Turan Büyükdi̇nç, Di̇lruba Tabay Sümbül, Sheikh Mansoor

Turkish Journal of Agriculture and Forestry

Daucus carota L. (carrot) is a commercially significant root vegetable widely cultivated in temperate regions for its edible taproot and valued for its high nutritional content. This study aimed to investigate the effects of drought stress on callus tissues of the Hatay black carrot (Daucus carota L. ssp. sativus var. atrorubens Alef.) genotype and to determine the impact of different gamma radiation doses on antioxidant enzyme activities. Black carrot callus tissues were exposed to gamma irradiation at doses of 0, 7, 8, and 9 Gy to evaluate their responses to drought stress. Antioxidant enzyme activities, including superoxide dismutase (SOD), …


Bioactive Profile And Mineral Composition Of Fruit Extracts From Four Wild Hawthorn (Crataegus Spp.) Species, Özlem Çakir, Kübra Çinar Topçu, Abdurrahman Sefali, İshak Bayyi̇ği̇t, Gülçe İlhan, Jyoti̇ Singh Feb 2026

Bioactive Profile And Mineral Composition Of Fruit Extracts From Four Wild Hawthorn (Crataegus Spp.) Species, Özlem Çakir, Kübra Çinar Topçu, Abdurrahman Sefali, İshak Bayyi̇ği̇t, Gülçe İlhan, Jyoti̇ Singh

Turkish Journal of Agriculture and Forestry

This study compared the antioxidant capacity, total phenolic content (TPC), phenolic composition, lipid oxidation level, andmineral profiles of extracts obtained from four wild hawthorn species (Crataegus tanacetifolia, C. orientalis subsp. orientalis, C. orientalissubsp. szovitsii, and C. monogyna) collected from northeastern Türkiye. Significant interspecific variations were observed in DPPH,FRAP, and CUPRAC assays. While C. monogyna had the highest reducing capacity and TPC, C. orientalis subsp. szovitsii had the highestDPPH activity. Ultra-high performance liquid chromatography coupled to tandem mass spectrometry analysis showed that catechin,epicatechin, chlorogenic acid, and quinic acid were the major phenolics, and were particularly abundant in C. monogyna. Despitehaving a …


Production Of The Antitumor Compound Deoxyharringtonine By Suspension-Culturedcells Of Cephalotaxus Hainanensis, Liang Wang, Muhammad Mubashar Zafar, Chongyu Wu, Zhiqiang Xiong, Jingyi Sun, Huapeng Sun, Hanqing Cong, Xuefei Jiang, Mahmoud F. Seleiman, Fei Qiao, Peter Nick Feb 2026

Production Of The Antitumor Compound Deoxyharringtonine By Suspension-Culturedcells Of Cephalotaxus Hainanensis, Liang Wang, Muhammad Mubashar Zafar, Chongyu Wu, Zhiqiang Xiong, Jingyi Sun, Huapeng Sun, Hanqing Cong, Xuefei Jiang, Mahmoud F. Seleiman, Fei Qiao, Peter Nick

Turkish Journal of Agriculture and Forestry

Plant cell fermentation can be a sustainable biotechnological alternative to the wild collection of medicinal plants. As aparadigm, we explored the potential of using the highly endangered endemic tree Cephalotaxus hainanensis, which accumulatescephalotaxine esters—potent anticancer compounds. We successfully established a suspension cell line able to convert cephalotaxineinto its esters, including deoxyharringtonine, harringtonine, isoharringtonine and homoharringtonine at a remarkable maximalconversion rate of up to 86%, when supplemented with L-homoleucine, a precursor for the side chains of these esters. Furthermore, byadding elicitors, we were able to enhance the yield significantly beyond the values expected from the complete conversion of the addedcephalotaxine. In …


Merritt-Putnam Symposium | Tumor-Associated Epilepsy And Epilepsy-Associated Tumors: Exploring The Bidirectional Crosstalk Between Tumors And Seizures, Tracy A Bedrosian, Michael Wong, Erin L Heinzen, Benjamin Deneen, Catherine A Christian-Hinman Feb 2026

Merritt-Putnam Symposium | Tumor-Associated Epilepsy And Epilepsy-Associated Tumors: Exploring The Bidirectional Crosstalk Between Tumors And Seizures, Tracy A Bedrosian, Michael Wong, Erin L Heinzen, Benjamin Deneen, Catherine A Christian-Hinman

Faculty, Staff and Students Publications

Links between cancerous and noncancerous brain tumors and epilepsy have long been recognized. However, recent clinical and preclinical studies emphasize that not only do tumors impinge on surrounding brain tissue in ways that promote hyperexcitability and epileptogenesis, but that neural activity also influences tumor progression. In this review, inspired by the Merritt-Putnam Symposium of the 2025 meeting of the American Epilepsy Society, we present a cross-disciplinary dialog between cancer and epilepsy research, including discussion of tumors and epilepsies that are more prominent in pediatric versus adult populations. First, we discuss the neuropathology, genetics, and surgical outcomes of epileptogenic brain tumors, …


Association Between Dietary Folate And Prostate Cancer Aggressiveness Among African Americans And European Americans, Lihchyun Joseph Su, Sarah O'Connor, Daniela Ramirez Aguilar, Minjae Lee, Harrison Wong, Hui-Yi Lin, Jeannette T. Bensen, James L. Mohler, Lenore Arab, Longgang Zhao, Ebonee N. Butler, Laura Farnan, Susan E. Steck Phd, Mph, Rd Feb 2026

Association Between Dietary Folate And Prostate Cancer Aggressiveness Among African Americans And European Americans, Lihchyun Joseph Su, Sarah O'Connor, Daniela Ramirez Aguilar, Minjae Lee, Harrison Wong, Hui-Yi Lin, Jeannette T. Bensen, James L. Mohler, Lenore Arab, Longgang Zhao, Ebonee N. Butler, Laura Farnan, Susan E. Steck Phd, Mph, Rd

Faculty Publications

Background: Despite the confirmed beneficial effects on preventing neural tube defects, concerns about high intakes of synthetic folate, or folic acid, in promoting cancer progression have been raised. This study evaluated the association between folate intake and prostate cancer (PCa) aggressiveness among African-American (AA) and European-American (EA) males. Methods: This study included 722 AA and 775 EA men with prostate cancer. Folate intake (dietary folate equivalent (DFE), synthetic folate, natural folate) was estimated using the National Cancer Institute Dietary History Questionnaire and detailed dietary supplement use questionnaire. Analyses included univariable comparisons of demographic and clinical characteristics of the two racial …


Montana Kaimin, February 26, 2026, Students Of The University Of Montana, Missoula Feb 2026

Montana Kaimin, February 26, 2026, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.


Turning Zwitterions Into Toughening Agents: Salt-Activated Microdomains In Poly(Vinyl Alcohol) Double-Network Hydrogels, Louis D. Zhang, Jintao Yang, Si Yu Zheng Feb 2026

Turning Zwitterions Into Toughening Agents: Salt-Activated Microdomains In Poly(Vinyl Alcohol) Double-Network Hydrogels, Louis D. Zhang, Jintao Yang, Si Yu Zheng

University Research

Zwitterionic hydrogels, although highly biocompatible, are widely regarded as mechanically fragile, with typical tensile strengths below 0.1 MPa, which restricts their use in load-bearing applications. Here, we address this limitation by integrating a polyzwitterionic network with a poly(vinyl alcohol) (PVA) network through high-speed pregelation agitation that enhances chain entanglement and induces flow orientation. By exploiting the salt-driven conformational transition of zwitterionic chains, a controlled salting-out step generates uniformly dispersed nanoscale microdomains that act as reversible energy-dissipating units. At the same time, balanced hydrogen bonding between the two networks moderates PVA crystallinity, limiting embrittlement while preserving elasticity. The resulting double-network hydrogel …


Quaker Campus, February 26, 2026 (Vol. 24, Issue 9), Whittier College Feb 2026

Quaker Campus, February 26, 2026 (Vol. 24, Issue 9), Whittier College

Quaker Campus

No abstract provided.


Computational Repurposing And Experimental Validation Of Ybx1 Inhibitors In Hepatocellular Carcinoma, Omar Karkoutly, Veerababu Nagati, Subhash Chauhan, Manish Tripathi Feb 2026

Computational Repurposing And Experimental Validation Of Ybx1 Inhibitors In Hepatocellular Carcinoma, Omar Karkoutly, Veerababu Nagati, Subhash Chauhan, Manish Tripathi

School of Medicine Publications

Background/Objectives: Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. While early-stage HCC can often be treated with surgical resection, ablation, or liver transplantation, advanced disease typically relies on systemic chemotherapy. Sorafenib is the standard first-line therapy for advanced and unresectable HCC; however, both intrinsic and acquired resistance remain major clinical challenges. The Y-box binding protein-1 (YBX1), a transcription factor implicated in drug resistance across multiple cancers, is highly expressed in HCC and represents a potential therapeutic target. This study aimed to identify novel YBX1 inhibitors using a drug repurposing strategy to overcome sorafenib resistance. Methods: A …