Digital Commons Network^™

Losing, Yet Winning, In Life’S Genetic Lottery, Jill Sisson Quinn, Ramya Rajagopalan

Creative Nonfiction Magazine

No abstract provided.

What Fish Oil Pills Are Hiding, David Schleifer, Alison Fairbrother

Creative Nonfiction Magazine

No abstract provided.

Collective Forgetting, Allison Marsh, Lizzie Wade

Creative Nonfiction Magazine

No abstract provided.

All Images Are Limited To Light & Dark, Marcy Miranda Janes

Creative Nonfiction Magazine

No abstract provided.

What Happened In Humbug Valley, Ana Maria Spagna

Creative Nonfiction Magazine

No abstract provided.

Seep, Mieke Eerkens

Creative Nonfiction Magazine

No abstract provided.

Regeneration, Nicole Walker

Creative Nonfiction Magazine

No abstract provided.

No Thirst, Michelle Lanzoni

Creative Nonfiction Magazine

No abstract provided.

Iyabo Is Yoruba For “The Mother Has Returned”, Amy Hassinger

Creative Nonfiction Magazine

No abstract provided.

Depredation, Matthew Ferrence

Creative Nonfiction Magazine

No abstract provided.

Turning Out The Lights, Donna Seaman

Creative Nonfiction Magazine

No abstract provided.

Evaluating The Efficacy Of A Mobile Epilepsy Education Package (Meep) Application Developed For The Parents/Caregivers Of Children With Epilepsy In Canada: Protocol For A Unicentre Parallel Open Randomized Trial, Dilek Sayik, Ayfer Acikgoz, Argerie Tsimicalis, Kenneth A. Myers

Journal of Pediatric Epilepsy

Epilepsy education can help address a multitude of concerns encountered by families of children with seizures. The Mobile Epilepsy Education Package (MEEP) was developed, tested and integrated into practice in Turkey to manage epilepsy and increase treatment compliance. This study aims to develop English and French versions of MEEP, adapt it culturally, and evaluate its effectiveness. A two-group, single-center, randomized controlled intervention trial with 1:1 allocation ratio will be conducted in the Pediatric Neurology Clinic of the Montreal Children’s Hospital. Seventy-two caregivers of children with epilepsy (intervention=36, control= 36), aged 1-17 years, will be recruited. Family Introduction Form, Epilepsy Information …

Collaborative Learning In Clinical Education As A Catalyst To Support Foundational Professional Competencies In Speech-Language Pathology: A Theoretical Framework, Lori-Ann Ferraro

Teaching and Learning in Communication Sciences & Disorders

As a part of every speech-language pathology graduate program in the US, clinical education is an integral and required element for both academic accreditation and the eventual clinical certification for students. Clinical education is significantly important when considering overall educational models because it is an aspect of a student’s education that contributes to their ability to make connections between what is learned in the classroom and its real-world clinical application while contributing to the acquisition of competencies. The 2:1 collaborative learning model is supported by sound learning theories and evidence from the literature. A theoretical framework was created to demonstrate …

Recent Advances In The Pharmacological Properties Of Scutellarin: Mechanistic Insights And Therapeutic Potential, Hind A. Satar, Emad Yousif, Ahmed Ahmed, Muna Bufaroosha

AUIQ Complementary Biological System

Scutellarin, a flavonoid glycoside primarily derived from Scutellaria baicalensis, has garnered increasing scientific interest for its multifaceted pharmacological properties. This review summarizes recent advances in our understanding of scutellarin's therapeutic effects, including its antioxidant, anti-inflammatory, neuroprotective, cardioprotective and anticancer activities. Emphasis is placed on elucidating its molecular mechanisms of action, such as modulation of the NF-κB, Nrf2, and PI3K/Akt pathways, and its role in regulating oxidative stress, inflammation, and apoptosis. Additionally, we discuss formulation innovations, including nanoparticle and liposomal delivery systems, aimed at overcoming scutellarin's poor oral bioavailability and enhancing therapeutic performance. Key limitations in current research …

George Sturgeon, Metal Fluorides & Vice Chair, Mark A. Griep, George D. Sturgeon

Department of Chemistry: Faculty Interviews

Dr. George Sturgeon was a chemistry professor at the University of Nebraska -Lincoln for 39 years, from 1964 to 2003. During his time at UNL, he spent 15 years as the vice chair. Something in his youth must have sparked an interest in chemistry because he earned a bachelor’s in that subject from the University of North Dakota in Grand Forks. Then, he traveled 870 miles east to Michigan State University in East Lansing where he earned his doctorate. Immediately after graduating, he joined the University of Nebraska-Lincoln in 1964 as an assistant professor but was soon promoted to associate …

Susceptibility Profile And Multiple Antibiotics Resistance Of Escherichia Coli, Klebsiella Spp., And Enterococci From Small-Scale Cattle Farms In Tennessee, Goodness Olakanmi, Maureen Nzomo, Bharat Pokharel, Abdullah Mafiz, Agnes Kilonzo-Nthenge

Food and Animal Sciences Faculty Research

Antimicrobial resistance in food–animal environments threatens sustainable production and public health, yet small farms remain poorly characterized as potential reservoirs of antimicrobial resistant bacteria. To address this, we investigated the prevalence and antimicrobial resistance profiles of Escherichia coli, Klebsiella spp., and Enterococcus spp. from small-scale cattle farms in Tennessee, USA. Methods: Over one year, 153 environmental samples (soil, manure, water) were collected from 17 farms. Target bacteria were isolated and confirmed using selective agar, biochemical tests, and PCR, and tested against 12 antibiotics using the Kirby–Bauer disk diffusion test. Multiple Antibiotic Resistance Index (MARI) and multidrug resistance (MDR) profiles …

Ns5-Targeting Nucleoside Analogs Inhibit Dengue Virus And Other Flaviviruses, Priyanka Bhakt, Swechha Pokharel, Yue Li, Tamanna Srivastava, Jesse Miller, Mark Dittmar, Yongqing Zhu, David Nguyen, Zachary Walter, Kasirajan Ayyanathan, Matthew Tudor, Chenguang Yu, Arnab Chatterjee, Holly Ramage, David Schultz, Sara Cherry

Department of Microbiology and Immunology Faculty Papers

Dengue virus (DENV) is a mosquito-transmitted flavivirus that circulates globally as four distinct serotypes and poses a substantial threat to public health. There are an estimated ~96 million symptomatic infections yearly, including severe cases of dengue fever, underscoring the urgency of identifying effective therapeutics targeting all four serotypes. Nucleoside analogs, which mimic endogenous nucleosides to inhibit viral RNA replication, offer a promising strategy for broad-spectrum antiviral development. Here, we conducted a high-throughput screen of 1,101 nucleoside analogs against DENV serotype 2 (DENV2) in a panel of human cell models, including human epithelial cells, hepatocytes, and fibroblasts. Candidates that were active …

Outsourcing Legal Modernity: Late Colonial Constitutionalism In Muslim Northern Nigeria, Rabiat Akande

Articles & Book Chapters

The final years of British imperial rule in Northern Nigeria witnessed efforts to source appropriate models of legal modernization from the Muslim world. The models afloat in constitutional discourse, those of Libya, Sudan, Pakistan, and Egypt, were held up by respective proponents as ideal for resolving the long-fraught question of the relationship between Islam and public law in a modern state. Yet, the evocations of these foreign models were idealized imaginaries; by framing these models as settled facts, the Northern Nigerian evocations flattened the constitutional experience of these states and obscured unfolding struggles over the nature of legal modernity. Against …

Accurate Interpretation Of Within-Host Dissemination Using Barcoded Bacteria, Rachel T Giorgio, My T Le, Ting Zhang, Caitlyn L Holmes, Karthik Hullahalli

2020-Current year OA Pubs

Bacterial dissemination across tissues is a critically important process influencing infection outcomes. Monitoring within-host dissemination is challenging because conventional measures of bulk bacterial burden cannot distinguish between lineages that are shared between tissues and those that replicate locally. This limitation can be overcome using barcoded bacteria, where deep sequencing of the barcode locus and comparisons of barcodes between tissues define which lineages spread within the host. Numerous studies have used barcoded bacteria to generate high-resolution maps of dissemination. However, since multiple cells in the infectious inoculum can contain identical barcodes, inferences about dissemination can be confounded when distinct lineages from …

Variable And Conserved Features Of Copy-Back Viral Genome Populations Generated De Novo During Sendai Virus Infection, Yanling Yang, Yuchen Wang, Carolina B López

2020-Current year OA Pubs

Copy-back viral genomes (cbVGs) are generated during the replication of negative-sense RNA viruses when the polymerase drops off from the genome and reattaches to the nascent strand. cbVGs have strong immunostimulatory properties and impact infection outcomes. Despite their importance, the composition and mechanisms of

Engineering Chimeric Antigen Receptor Cd4 T Cells For Alzheimer's Disease, Pavle Boskovic, Rotem Shalita, Wenqing Gao, Hailey Vernon, Yu Lin Deng, Marco Colonna, Robbie G Majzner, Ido Amit, Jonathan Kipnis

2020-Current year OA Pubs

Alzheimer's disease (AD) is the prevailing cause of age-associated dementia worldwide. Current standard of care relies on antibody-based immunotherapy. However, antibody-based approaches carry risks for patients, and their effects on cognition are marginal. Increasing evidence suggests that T cells contribute to AD onset and progression. Unlike the cytotoxic effects of CD8

Larval Zebrafish Minimize Energy Consumption During Hunting Via Adaptive Movement Selection, Thomas Darveniza, Robert Wong, Shuyu I Zhu, Zac Pujic, Biao Sun, Matthew Levendosky, Ramesh Agarwal, Michael H Mccullough, Geoffrey J Goodhill

2020-Current year OA Pubs

Animals must balance behavioral goals with the energetic costs of movement. How such trade-offs are implemented algorithmically during natural behavior, and how they adapt to changing energetic constraints, remains poorly understood. Here we show that larval zebrafish adjust their motor strategies during prey hunting to minimize energy expenditure. Using high-speed video tracking and 3D computational fluid dynamics simulations, we quantified the energy costs (in Joules) of different movement types across three developmental stages. While the structure of discrete movement types ("bouts") remained stable with age, their selection probabilities changed depending on their energetic cost, such that more expensive bouts were …

State Siting Of Renewable Energy – Preemptive Power Grab Or Power Play?, Sarah Everhart

Duke Environmental Law & Policy Forum

The United States needs more—and cleaner—energy. Experts project that in the near future, the United States will need to significantly increase its electricity generation. Currently, the burning of fossil fuels remains a significant source of power generation in the United States. However, these fossil fuels produce greenhouse gases that are one of the main drivers of the impending and likely disastrous, climate change. Therefore, it has never been more vital to decarbonize the energy sector. However, there are two significant impediments to the deployment of renewable energy: restrictive local siting laws and community opposition.

According to the Sabin Center for …

Environmental Law’S Missing Piece: The Right To Nature, Ori Sharon

Duke Environmental Law & Policy Forum

For decades, environmental law has been trapped in a binary value system: it either treats nature instrumentally, as property to be used for human benefit, or views it as intrinsically valuable, deserving protection for its own sake. Both approaches, though ethically powerful, have struggled to deliver consistent and enforceable protections. As ecological crises deepen, this conceptual stalemate is no longer just inadequate—it is dangerous.

This article argues that environmental law remains structurally incomplete. It has overlooked a third category of value—relational value—long recognized in ethics and conservation science but largely absent from legal doctrine. Relational values arise from the lived, …

Long-Acting Interleukin-7 Improves The Efficacy Of Oncolytic Viral Therapy In Glioblastoma, Yuping Derek Li, David A Giles, Yi Huang, Ashwani Kesarwani, Tong Hu, Logan Page, Amanda De Andrade Costa, Jingqin Luo, Mai T Dang, Albert H Kim, John F Dipersio, David T Curiel, Michael S Diamond, Milan G Chheda, Et Al.

2020-Current year OA Pubs

Despite advances in immunotherapy, the prognosis for patients with glioblastoma (GBM) remains poor. The efficacy of GBM-targeted immunotherapies is limited by the paucity of functional T cells in the tumor microenvironment, a consequence of the local and systemic immunosuppression prevalent in patients with GBM. To overcome these challenges, here we develop a treatment strategy we term "expand and pull," which uses systemic administration of rhIL-7-hyFc, a long-acting recombinant human interleukin-7, to increase peripheral T cell abundance ("expand"), followed by intratumoral oncolytic virus treatment to recruit these cells to the tumor microenvironment ("pull"). We show that rhIL-7-hyFc improves the efficacy of …

S6k1 Modulates Stat3 Activation To Promote Resistance To Radiotherapy In Lung Cancer, Ali Calderon-Aparicio, Noelle Francois, Tyler Grenda, Shan Xu, Olugbenga Okusanya, Jun He, Nicole L Simone

Department of Radiation Oncology Faculty Papers

Radiotherapy is a mainstay in the management of locally advanced lung cancer; however, intrinsic and acquired radioresistance contribute to poor prognosis. S6K1, a serine/threonine kinase, regulates cell growth, protein synthesis, and survival, and is increased in tumors, which is linked to enhanced survival under therapeutic stress, including radiation. The mechanisms, however, are not fully understood. This study investigates the role of S6K1 in lung cancer radioresistance and the mechanisms involved. Intrinsic radioresistance in lung cancer cells was associated with increased S6K1 activation. Pharmacologic inhibition or genetic deletion of S6K1 enhanced radiosensitivity both in vitro and in vivo, highlighting the therapeutic …

Syndecan-1-Targeted Therapeutic Antibody Impairs Macropinocytosis And Elicits Antitumor Immunity In Pancreatic Cancer, Zecheng Yang, Madelaine S Theardy, Shuaitong Chen, Yongkun Wei, Mitsunobu Takeda, Yue Zeng, Xiaofei Wang, Jun Yao, Jennifer Li, Prapassorn Thirasastr, Jangho Park, Yangxi Zheng, Long T Vien, Khalida M Wani, Huamin Wang, Sisi Gao, Tim Heffernan, Lawrence Kwong, Ignacio I Wistuba, Laura Bover, Giulio F Draetta, Haoqiang Ying, Wantong Yao

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with a 5-year survival rate of just 13%. While the development and early clinical use of small molecules targeting oncogenic KRAS mutations, key drivers of PDAC, have shown promise, resistance to these targeted therapies remains a significant challenge. We recently identified Syndecan-1 (SDC1), a highly expressed heparan sulfate proteoglycan, as a critical KRAS effector protein that promotes nutrient salvage and tumor growth. Here, we report the development of a human-specific monoclonal antibody (anti-SDC1 mAb) that inhibits PDAC cell proliferation in vitro and suppresses PDAC tumor growth in vivo. Mechanistically, …

Micro-Refuges Or Ecological Traps: Context-Dependent Effects Of Rock Pools On Intertidal Biodiversity Across Latitudes, Louise B. Firth, Andrea Desiderato, Antony M. Knights, J. David Aguirre, Juan C. Astudillo, Juan C. Azofeifa-Solano, David T. Bilton, Su Yin Chee, Hartvig C. Christie, Ronaldo A. Christofoletti, Amelia Curd, Katherine A. Dafforn, Megan N. Dethier, Yun Wei Dong, Gabin Droual, Stanislas F. Dubois, Free Espinosa, Ally J. Evans, Andy Foggo, Stephen J. Hawkins, Mick E. Hanley, Ben P. Harvey, Eliza Heery, Seokwoo Hong, Amanda R. Hsiung, Tommy T.Y. Hui, Mar Humet, Katrin Iken, Soniya B. Jethva

School of Biological and Marine Sciences

AimWe investigated how local-scale environmental heterogeneity influences biodiversity patterns across broad biogeographic gradients, using intertidal microhabitats as a model system within one of the most environmentally stressful ecosystems on Earth.LocationIntertidal habitats at 26 locations (two rocky shore sites per location) across six continents, spanning 98° of latitude (38°S to 60°N).Time Period2019–2022.Major Taxa StudiedAlgae, sessile and mobile invertebrates.MethodsWe compared biodiversity and thermal environments across contrasting microhabitats (rock pools and adjacent emergent rock) along a latitudinal gradient, sampling during environmentally ‘milder’ and ‘harsher’ periods. Biodiversity was quantified using multiple richness metrics (mean, total, unique taxa) and functional diversity.ResultsMicrohabitat differences strongly influenced biodiversity …

Spatiotemporal Histogenesis Of The Developing Human Cerebellum Reveals Dynamic Layering Of Bergmann Glia, Guanyi He, Simon Du, Henry Tan, Sri Yellampally, Anders W Erickson, Virginia Fernandez, Ferechte Encha-Razavi, Kimberley A Phillips, Christine Haberler, Nicole Amberg, Victor Borrell, Paul A Northcott, Michael D Taylor, Kathleen J Millen, Parthiv Haldipur

Faculty, Staff and Students Publications

Bergmann glia (BG) are a specialized glial population essential for cerebellar development, yet their developmental timeline and molecular identity in the human cerebellum remain poorly understood. Here, we combined detailed histopathological analysis with spatial transcriptomics and single-nucleus RNA sequencing to generate a developmental atlas of human cerebellar BG. Histology revealed that BG emerge around 11 post-conception weeks (PCW), initially serving as a scaffold for Purkinje cells (PCs) migrating into the PC layer of the cerebellar cortex. Following the establishment of a multilayered PC arrangement, BG form a distinct parallel layer separated from the PCs by the lamina dissecans (LD), with …

Research Note: John Dewey On Nationalism, Leonard J. Waks

Dewey Studies

No abstract provided.