Digital Commons Network^™

Tribological Properties Evaluation Of Powdered Pentaclethra Macrophylla Pod And Gum-Arabic For Brake Pad, I. Iloabachie, A. Nwankwo, C. Ogbu

Engineering and Technology Journal

This study evaluated the tribological properties of an eco-friendly brake pad. Pentaclethra macrophylla pod was pulverized into powder form and sieved. Two particle sizes of 150 μm and 210 μm were obtained after sieving, and the sieved particles were divided into two portions, with one portion carbonized and the other uncarbonized. The brake pad composite was produced by varying the composition of powdered reinforcement in the order of 10, 20, 30, 40, and 50 wt.%. The formulation was poured into a metal mould 50 × 50 × 8 mm3, placed in a hot platen press at a temperature of about …

Effect Of Pistacia Khinjuk Shell And Rapeseed Straw Particles On Mechanical Properties And Thermal Properties Of Polyester-Based Composites, Sana Muhamadali, Rzgar Abdalrahman

Engineering and Technology Journal

Composite materials are widely employed across various industries due to their superior mechanical and thermal properties compared to metals, offering improved performance with reduced weight. Polyester-based composites, in particular, have gained attention for their versatility and ease of processing, and their properties can be further enhanced by incorporating suitable fillers. In response to increasing environmental concerns, recent research has focused on natural fillers as sustainable alternatives, owing to their biodegradability, low cost, and minimal ecological impact. Despite growing interest, the combined application of underutilized bio-based materials, specifically Pistacia khinjuk (PK) shell particles and Rapeseed straw (RS) fibers within polyester matrices, …

Treatment For Dairy Waste Water Using A Photoreactor (Uv And Hydrogen Peroxide) As An Alternative Treatment Technique, Anwar Hashim, Hala Abdulkareem, Mohammed Salman

Engineering and Technology Journal

The contamination of vital life supplies by industrial waste, especially dairy effluent, is a growing global concern. This study investigates the impact of advanced oxidation processes (AOP) on treating dairy wastewater utilizing UV/H2O2 AOP. Utilized ultraviolet lamps in conjunction with hydrogen peroxide oxidant reagent (0.6, 1.2, 1.8, and 2.4 ml/L) in batch experiments under varying parameters to optimize the treatment of dairy wastewater before and following its introduction to the advanced oxidation process (AOP) system, by measuring Biological Oxygen Demand (BOD) and Chemical Oxygen Demand (COD). The impacts of varying circulation durations in a photocatalytic system (60-360 minutes), flow rates …

Mapping Agricultural Lands At Risk Of Meteorological Drought In Iraq Using Geostatistics, Mohammed Azeez, Hisham Al Sharaa, Abdul Razzak Ziboon

Engineering and Technology Journal

Identifying vulnerable agricultural lands at risk of meteorological drought is challenging for researchers. Its complexity lies in the fact that agricultural lands are irrigated by two sources: rain and rivers. In this research, we have developed a geostatistical model to separate river-dependent lands unaffected by meteorological drought waves and land vulnerable to the risk of meteorological drought. The inputs of this geostatistical model are the vegetation index and the humidity index extracted from Landsat 8, the rainfall from CHIRPS, and the LULC from ESA. The correlation between the Normalized Difference Vegetation Index (NDVI), the Normalized Difference Moisture Index (NDMI), and …

A Review Of A Study On Improving The Performance Of Spherical Solar Stills, Faiz Jodah, Wissam ِAlawee, Hayder Dhahad, Z.M. Omara

Engineering and Technology Journal

The urgent need for potable water has increased despite water covering much of the Earth's surface. Solar desalination, which uses solar energy to produce fresh water, is an eco-friendly and cost-effective solution, especially for remote areas lacking clean drinking water. This technology is valuable even in deserts with no other freshwater sources. However, conventional solar stills have low efficiency. To address this, various experiments have been conducted to enhance the daily output of solar stills by improving evaporation and condensation rates, which standard distillers cannot achieve. This innovation in using solar power thus finds its place even on desert sands …

The Physical World Of The Greeks, Samuel Sambursky

Hannah Arendt Marginalia - All

London : Routledge and Paul, 1956.

Call#: Q127.G7 S313 1956

Contains underlining and marginalia

PDF information: 17 pages - 5.7MB

Documents On German Foreign Policy, 1918-1945, From The Archives Of The German Foreign Ministry., AuswäRtiges Amt Germany

Hannah Arendt Marginalia - All

Washington : U.S. Govt. Print. Off., 1949-< 1983>

Call #: JX691 .A45

Contains underlining and marginal lining

PDF information: 31 Pages - 12MB

Between Peaks And Traditions: Indigenous Andean Women Mountaineers, Hybrid Identities, And Decolonial Resistance Through Sport, Ilina Arsova, Lars Dzikus

Journal of Global South Sport Studies

This paper explores the hybrid identities of Indigenous Bolivian women mountaineers, focusing on how they embrace and resist elements of both Indigenous and Western traditions through sports. Challenging dominant Western narratives of mountaineering (Rak, 2021), these women engage in climbing as an act of cultural preservation (Haynes, 2013; Rak, 2021) and gender advocacy (U.N. Women, 2021). Informed by Indigenous feminism (Caravajal, 2019; Green, 2020) and social identity theory (Tajfel & Turner, 1979), the study explores the intersections of gender, culture, and mountain sports in the South American Andes. Through an interpretivist lens, this study uses narrative inquiry (Clandinin & Connelly, …

Ifn Signaling Is Associated With Radiotherapy Response In Malignant Peripheral Nerve Sheath Tumors., Iowis Zhu, Julian Chien, Gabriel E Rech, Kanish Mirchia, Sixuan Pan, Kaeli Miller, Joanna Pak, Rosanna Wustrack, Varun Monga, Steve E Braunstein, Mark D Adams, Line Jacques, Melike Pekmezci, S John Liu, Harish N Vasudevan

Faculty Research 2026

Patients with malignant peripheral nerve sheath tumors (MPNSTs) have poor outcomes despite multimodal treatment with surgery, radiation, and systemic therapy. The responses to radiotherapy (RT) are mixed, and the biologic mechanisms underlying this heterogeneity in the radiation response of MPNSTs are not understood. Here, we combined bulk and single-cell transcriptomics, genome-wide CRISPR interference screens, and multiplatform molecular analysis across MPNST cells, mouse allograft models, and patients' samples to understand the mediators of the radiation response. Our data revealed that MPNSTs, but not benign plexiform neurofibromas, induced a type I IFN signature that functionally mediated the radiation response. Moreover, irradiation of …

Ifn Signaling Is Associated With Radiotherapy Response In Malignant Peripheral Nerve Sheath Tumors., Iowis Zhu, Julian Chien, Gabriel E Rech, Kanish Mirchia, Sixuan Pan, Kaeli Miller, Joanna Pak, Rosanna Wustrack, Varun Monga, Steve E Braunstein, Mark D Adams, Line Jacques, Melike Pekmezci, S John Liu, Harish N Vasudevan

Faculty Research 2026

Patients with malignant peripheral nerve sheath tumors (MPNSTs) have poor outcomes despite multimodal treatment with surgery, radiation, and systemic therapy. The responses to radiotherapy (RT) are mixed, and the biologic mechanisms underlying this heterogeneity in the radiation response of MPNSTs are not understood. Here, we combined bulk and single-cell transcriptomics, genome-wide CRISPR interference screens, and multiplatform molecular analysis across MPNST cells, mouse allograft models, and patients' samples to understand the mediators of the radiation response. Our data revealed that MPNSTs, but not benign plexiform neurofibromas, induced a type I IFN signature that functionally mediated the radiation response. Moreover, irradiation of …

Jax Animal Behavior System (Jabs), A Genetics-Informed, End-To-End Advanced Behavioral Phenotyping Platform For The Laboratory Mouse., Anshul Choudhary, Brian Q Geuther, Thomas J. Sproule, Glen L Beane, Vivek Kohar, Jarek Trapszo, Vivek Kumar

Faculty Research 2026

Automated detection of complex animal behavior remains a challenge in neuroscience. Developments in computer vision have greatly advanced automated behavior detection and allow high-throughput preclinical and mechanistic studies. An integrated hardware and software solution is necessary to facilitate the adoption of these advances in the field of behavioral neurogenetics, particularly for non-computational laboratories. We have published a series of papers using an open field arena to annotate complex behaviors such as grooming, posture, and gait as well as higher-level constructs such as biological age and pain. Here, we present our integrated rodent phenotyping platform, JAX Animal Behavior System (JABS), to …

Jax Animal Behavior System (Jabs), A Genetics-Informed, End-To-End Advanced Behavioral Phenotyping Platform For The Laboratory Mouse., Anshul Choudhary, Brian Q Geuther, Thomas J. Sproule, Glen L Beane, Vivek Kohar, Jarek Trapszo, Vivek Kumar

Faculty Research 2026

Automated detection of complex animal behavior remains a challenge in neuroscience. Developments in computer vision have greatly advanced automated behavior detection and allow high-throughput preclinical and mechanistic studies. An integrated hardware and software solution is necessary to facilitate the adoption of these advances in the field of behavioral neurogenetics, particularly for non-computational laboratories. We have published a series of papers using an open field arena to annotate complex behaviors such as grooming, posture, and gait as well as higher-level constructs such as biological age and pain. Here, we present our integrated rodent phenotyping platform, JAX Animal Behavior System (JABS), to …

Surgical Removal Of Visceral Adipose Tissue Has Therapeutic Benefit In Male Appnl-F Mice, Samuel A. Mcfadden, Yimin Fang, Kathleen Quinn, Mackenzie R. Peck, Jenelle E. Chapman, Tiarra Hill, Andrzej Bartke, Erin R. Hascup, Kevin Hascup

Articles

Purpose:  Visceral white adipose tissue (vWAT) accumulation causes systemic inflammation, insulin resistance, metabolic syndrome, and senescent cell accumulation that are risk factors for Alzheimer’s disease (AD). Visceral fat removal (VFR) improves metabolism and reduces pro-inflammatory cytokines.  We hypothesized that VFR removal in AD mice would improve metabolism and cognition.

Methods:  Male and female APP^NL-F mice underwent sham or vWAT surgical resection (periovarian or epididymal and perirenal) at 4 (pre-symptomatic) and 16 (symptomatic) months of age to understand interventional and therapeutic effects, respectively.  At 18 months of age, glucose metabolism and novel object recognition (NOR) memory were assayed followed by …

Du Journal De Deuil À L’Œuvre De Sépulture : « Lo » (Thanassis Vassiliou, 2021-2025), Marie Martin

Regards

After his mother’s death in 2017, Thanassis Vassiliou returned to Greece and began filming. The instinctive act of recording aimed both to come to terms with the now definitive absence in places still filled with memories, and to document his own reactions, attempting to preserve them even if he could not fully understand them. These filmic notes could perhaps, later on, allow another perspective, according to the dynamic that Antoine Compagnon aptly analyzed as paradoxical in relation to Barthes’s Mourning Diary: “mourning and narrative are antinomic, but [...] only narrative [...] is capable of expressing the experience of mourning, …

A Review Of Interaction Between Sleep Apnea And Apoe E4 On The Risk Of Dementia, Xiuhua Ding, Carol Watwood, Amit Patel, Krupa Hegde, Brooke Mahanna, Lindsey Escudero, Jean Neils-Strunjas Ph.D, Ccc-Slp

Faculty Publications

Dementia has a significant impact on individuals, families, communities, and the economy. Alzheimer’s disease (AD) accounts for 60–80% of dementia cases. The APOE e4 allele is well known as the primary genetic risk factor for AD and dementia. Studies have also shown that sleep apnea increases the risk of dementia. Some research further suggests a possible interaction between sleep apnea and the APOE in dementia development; however, this relationship remains unclear. The purpose of this study is to synthesize evidence from the existing literature and report findings on the relationship between APOE, sleep apnea, and dementia. A systematic search of …

Jackfruit Peel Valorization Through An Integrated Biorefinery Approach, Rohil Kumar K Mr

Theses and Dissertations

Jackfruit (Artocarpus heterophyllus) peel (JFP), an abundantly available lignocellulosic biomass, remains largely underutilized despite being rich in cellulose, hemicellulose, lignin, and pectin. In India, approximately 13,460 hectares are under jackfruit cultivation, with Panruti in Tamil Nadu as a major production zone. The discarded peel often contributes to environmental pollution and greenhouse gas emissions. The present study emphasizes sustainable valorization of JFP through an integrated biorefinery framework for generating value-added bioproducts.

Major biopolymers, cellulose, hemicellulose, lignin, and pectin were extracted and fractionated, followed by detailed physicochemical characterization using FTIR, NMR, XRD, SEM, TGA, DSC, GPC, and BET analyses. Pectin extraction with …

Biomechanical Characterization Of Porcine Lower Limb Arteries For Preclinical Evaluation Of Peripheral Vascular Devices, Barbara Batista De Oliveira, Frazer Heinis, Anastasia Desyatova, Jason Mactaggart, Alexey Kamenskiy

Journal Articles

Purpose Peripheral artery disease (PAD) predominantly affects the lower extremities, where complex biomechanical deformations during limb flexion contribute to disease progression and treatment failure. While human and cadaver studies have characterized these deformations, preclinical device testing requires large-animal models that replicate human arterial anatomy and biomechanics. Swine are commonly used, yet their biomechanical comparability to humans remains poorly defined. Methods We performed a detailed morphometric and biomechanical analysis of the external iliac (EIA), superficial femoral (SFA), and popliteal (PA) arteries in 20 Yucatan and 16 domestic swine using computed tomography angiography. Arteries were evaluated in straight and flexed limb postures …

The Rider (2026-03-02), Daniela Chapa-Reyes

The Rider Archives

Vol. 11, No. 21

The U Visa At 25: Legislative Missteps, Bureaucratic Neglect, And Geographic Roulette, Jason A. Cade

Scholarly Works

A quarter century ago, Congress created the U visa with dual goals: protecting immigrant crime victims and facilitating law enforcement cooperation by removing deportation barriers to crime reporting. Yet the program as implemented has fallen dramatically short of these aims. This Essay provides the first comprehensive analysis of the U visa's structural failures at its twenty-fifth anniversary. Two fundamental design flaws plague the program. First, Congress capped U visas at 10,000 annually-far below actual need-while the immigration agency has consistently failed to implement congressionally-authorized interim protections. The result is that, as of 2025, applicants wait five years for work authorization …

Poly(Adp-Ribose) Glycohydrolase Enforces P21 Degradation Via Deparylation To Promote Gastric Cancer Progression, Yangchan Hu, Qimei Bao, Yixing Huang, Yan Wang, Xin Zhao, Junjun Nan, Yuxin Meng, Mingcong Deng, Yuancong Li, Zirui Zhuang, Hanyi He, Dan Zu, Yuke Zhong, Chunkai Zhang, Bing Wang, Ran Li, Yanhua He, Qihan Wang, Min Liu, John A Tainer, Yin Shi, Xiangdong Cheng, Ji Jing, Zu Ye

Faculty, Staff and Student Publications

Dysregulation of cell cycle checkpoints is a cancer hallmark, with ubiquitination-controlled protein stability playing a pivotal role. Although p21, a key cyclin-dependent kinase inhibitor, is tightly regulated by ubiquitin-mediated degradation, the key upstream modulators of its ubiquitination remain incompletely defined. Here, we identify poly(ADP-ribose) glycohydrolase (PARG) as a regulator of p21 stability in gastric cancer (GC) cells. We show that PARG expression is markedly upregulated in GC tissues and correlates with poor patient prognosis. Functional assays revealed that genetic depletion of PARG triggers G2/M phase arrest and impairs GC cell proliferation. Mechanistically, we demonstrate that PARG loss enhances p21 PARylation, …

Mechanometabolism Instructs Hematopoietic Stem Cell Specification, Paulina D Horton, Alina Syed, Michelle Winkler, Abishek B Vaidya, Michael Rariden, Neha Arora, Yong Zhou, Michihiro Kobayashi, Momoko Yoshimoto, Hyun Jung Lee, Hyun-Eui Kim, John P Hagan, Catherine Denicourt, Travis I Moore, Pamela L Wenzel

Faculty, Staff and Student Publications

Mechanical force generated by blood flow stimulates emergence of the first hematopoietic stem cells (HSCs) that populate the blood system. Force drives the transition of HSC precursors from an endothelial to hematopoietic identity, yet the molecular regulation of this fate switch remains poorly understood. We report that shear stress triggers adaptation in mitochondrial composition, ultrastructure, and function, which are essential for hematopoietic fate and engraftment potential. Shear stress remodels mitochondria in hemogenic endothelium by promoting mitochondrial gene transcription and protein synthesis. Laminar flow selectively initiates translation of 5' terminal polypyrimidine (5'TOP) motif-containing transcripts, which commonly encode ribosome and translation machinery. …

Rooted Wisdom Ecofeminist Tarot, Daniella Orias

Electronic Theses and Dissertations 2020 - Present

This dissertation explores the potential of applying tarot as a pedagogical tool in connection with ecofeminist theories in order to assess if tarot can be a meaningful pedagogical modality to improve learner comprehension. The dissertation is guided by six research questions, explored in the introduction section, in order to examine how tarot embodies ecofeminist critiques of dualistic Western thought. In Chapter 1, the dissertation begins by providing a foundational understanding of ecofeminism, tarot, and pedagogy in order to provide key background information and assess the current conversations around ecofeminism, queer and nature-based tarot decks, and the basis of critical pedagogy. …

Ectopic B Lymphocyte Follicles Exacerbate Ischemic Brain Damage Via Mif-Cd74/Cxcr4 And Interferon Signaling, Sheng Yang, Hang Zhang, Lu-Lu Xu, Luo-Qi Zhou, Yun-Hui Chu, Lian Chen, Xiao-Wei Pang, Lu-Yang Zhang, Li-Fang Zhu, Ming-Hao Dong, Ke Shang, Jun Xiao, Long-Jun Wu, Wei Wang, Dai-Shi Tian, Chuan Qin

Faculty, Staff and Student Publications

Neuroinflammation, encompassing both innate and adaptive immune responses, plays a crucial role in ischemic stroke. Although B lymphocytes are central to adaptive immunity, their contributions to ischemic stroke remain poorly understood. Here, we demonstrated that B lymphocytes accumulate in ischemic lesions, forming germinal center-like structures at the later stage after stroke, which mainly depended on in situ proliferation. This accumulation correlated with worsened neuroinflammation and ischemic injury, whereas B cell depletion reduced chronic brain damage during stroke. Mechanistically, microglia recruited B cells into ischemic lesions through MIF-CD74/CXCR4 signaling during the early phase of stroke, while IFN-related pathways in B cells …

Activin A Secretion By Muscle-Repairing Macrophages Induces Heterotopic Ossification In Mice, Wenqiang Yin, Kazuo Okamoto, Asuka Terashima, Warunee Pluemsakunthai, Takehito Ono, Taku Ito-Kureha, Shizuo Akira, Yoshinobu Hashizume, Roland Baron, Satoshi Ueha, Kouji Matsushima, Martin M Matzuk, Yuji Mishina, Hiroshi Takayanagi

Faculty, Staff and Students Publications

The immune system is not only essential for host defense, but it is also involved in tissue maintenance and disease pathogenesis. Macrophages play a key role in tissue repair, fibrosis, and tumorigenesis, but the mechanisms underlying their multifunctionality have not been fully explored. Here, we identified Mrep (Ly6ChiCX3CR1loPDPN+CD9+) as a crucial subset of macrophages for muscle regeneration after muscle injury. Muscle regeneration required Mrep-derived activin A, which was produced via the TLR4/TIR domain-containing adapter-inducing interferon-β/TANK-binding kinase 1/interferon regulatory factor 3/7 signaling pathway in response to muscle injury. Mrep exerted pathological effects by secreting activin A in a model of genetically …

Co-Electrospinning Polyacrylonitrile (Pan) / Polymer Of Intrinsic Microporosity-1 (Pim-1) For Electrochemical-Based Sensor For Pyridine Detection And Absorption, Samar A. Salim

Nanotechnology Research Centre

The electrospinning of the polymer of intrinsic microporosity-1 (PIM-1) poses challenges due to its limited solubility and tendency to form bead-like structures at high concentrations. This work details the synthesis and analysis of electrospun composite fibers made from polyacrylonitrile (PAN) and PIM-1 for electrochemical applications. The data analysis confirmed the successful incorporation of PIM-1 into the PAN matrix. The fiber characteristics were significantly influenced by PIM-1 loading (1–10%), resulting in fiber diameters ranging from 0.8 to 1.7 μm. A 10% concentration of PIM-1 results in the formation of macropores with diameters ranging from 0.5 to 1.7 μm. Optical analysis using …

Intouch Week Of March 2, 2026, New York Medical College

InTouch

• Kartik Prabhakaran, M.D., to Lead Department of Surgery
• Uncovering an Early Driver of Pulmonary Arterial Hypertension
• What if Banana Bags Came Ready to Use?
• NYMC and TU Host "Ninety Minutes: The Medical Magazine of the Web"
• Pet the Stress Away Brings Comfort to NYMC 
• Free Shipping on NYMC Gear
• Student Spotlight: Building an Orthopedic Future

Designing Novel Bisquinoline Antimalarials From Historical 4-Aminoquinolines To Combat Drug-Resistant Malaria, Mason J. Handford, Yuexin Li, Terry Riscoe, Xiaowei Zhang, Jane X. Kelly, Michael K. Riscoe

Chemistry Faculty Publications and Presentations

Plasmodium falciparum, the deadliest causative agent of malaria, continues to evade eradication efforts through widespread drug resistance. The recent development of ADC-028, a 4-aminoquinoline antimalarial with excellent activity and pharmacokinetic properties, prompted the investigation of bisquinoline analogs featuring similar structural motifs. Here, we describe a structure-activity relationship study that guided the optimization of compounds with key features, including the 4-anilinoquinoline core and diverse bridging linkers. Several analogs exhibited potent in vitro activity (IC50 < 20 nM) against both drug-sensitive and multidrug-resistant P. falciparum strains, while maintaining favorable cytotoxicity profiles. Among them, 25 demonstrated improved intrinsic metabolic stability (t1/2 = 121 min) and potent in vivo efficacy (ED50 = 0.32 mg/kg/day), achieving complete curative protection at a reduced dose compared to ADC-028. While 25 showed moderately reduced oral bioavailability (F = 43%) and a shorter half-life (T1/2 = 27.2 h) relative to ADC-028, its enhanced in vivo efficacy underscores its therapeutic potential. This work highlights a promising path forward in developing antimalarials that retain the efficacy of legacy compounds while overcoming modern resistance mechanisms.

Targeting Cancer With T Cells: Preclinical And In Silico Insights To Improve Immunotherapies, Nina Obertopp

USF Tampa Graduate Theses and Dissertations

T-cell–based immunotherapies are often constrained by limited trafficking and persistence in tumors and by functional exhaustion under chronic antigen exposure. This dissertation addresses these barriers through two distinct strategies: (i) preclinical studies testing how radiation therapy modulates tumor-infiltrating lymphocytes (TIL) therapy, and (ii) agent based modeling (ABM) to optimize treatment day treatment-free intervals (TFI) in T-cell engager (TCE) therapy. (i) In a human papillomavirus–positive (HPV⁺) head-and-neck cancer (HNC) model, a single local-dose of RT (8 Gy) delivered five days before tumor harvest increased the success and functional quality of ex vivo TIL outgrowth from tumor fragments, enriching polyfunctional CD8⁺ subsets. …

Cell Type-Specific Gene Regulatory Atlas Prioritizes Drug Targets And Repurposable Medicines In Alzheimer's Disease, Yunxiao Ren, Ming Hu, Yang E Li, Andrew A Pieper, Jeffrey Cummings, Feixiong Cheng

2020-Current year OA Pubs

Alzheimer's disease (AD) is a complex and poorly understood neurodegenerative disorder that lacks sufficiently effective treatments. Computational and integrative analyses that leverage multiomic data provide a promising strategy to uncover disease mechanisms and identify therapeutic opportunities. Here, we develop a cell type-specific regulatory atlas of the human middle temporal gyrus via leveraging single-nucleus RNA-seq (1,197,032 nuclei) and ATAC-seq (740,875 nuclei) data sets from 84 donors across four stages of AD neuropathological change (ADNC). We observe differential gene expression for six major cell types intensified at severe ADNC. Integrating peak-to-gene linkages and motif enrichment analyses, we reconstruct transcription factor (TF)-target gene …

The Relationship Between Apparent Potentiation And The Magnitude Of The Control Response, Joe Henry Steinbach, Gustav Akk

2020-Current year OA Pubs

The effect of a potentiating drug on ion channel function is typically evaluated by comparing current responses to the control agonist in the presence and absence of the potentiator. Differences in ratios of responses are then taken as proof of distinct potentiation properties when comparing modulation by different compounds. In these experiments, the concentration of the agonist is typically kept low to generate a small fractional control response. The precise relative magnitude of the control response is, however, not standardized among labs and can range from a concentration producing a response equal to just 2% of maximal (EC2) to over …