Digital Commons Network^™

Sickle Cell Visualization In Vivo In Humans: Microvascular Occlusion Formation And Hemorheological Indices, Marisa M Morakis, Luojie Huang, Gregory N. Mckay, Sophie Lanzkron, Lydia H. Pecker, Nicholas J. Durr

Cardeza Foundation for Hematologic Research

Vaso-occlusion is a signature pathology of sickle cell disease (SCD). However, the lack of in vivo methods to observe individual blood cell dynamics in humans limits our understanding of occlusion formation mechanisms. We present a novel in vivo, noninvasive, label-free, and high-resolution imaging technique to study blood flow and sickled cell behavior in affected individuals. We used oblique back-illumination microscopy (OBM) to capture videos of 91.0 ± 42.3 sublingual capillaries in each of 10 participants with SCD before and after red cell transfusions and compared the measurements to 10 unaffected controls. With direct observation of blood cell activity, we identified …

2026-03-04 [Review] ‘Son Of The White Mare’ Oozes Surrealism, Keagen Brooks-Torres

The Spectator Online

No abstract provided.

A Neural Circuit Framework For Economic Choice: From Building Blocks Of Valuation To Compositionality In Multitasking, Aldo Battista, Camillo Padoa-Schioppa, Xiao-Jing Wang

2020-Current year OA Pubs

Value-guided decisions are a cornerstone of cognition, yet the underlying circuit-level mechanisms remain elusive. We used reinforcement learning to train recurrent neural network models endowed with Dale's law on a battery of economic choice tasks, which revealed a two-stage computational framework. First, value estimation occurs at the input level, where learned weights store subjective preferences and approximate the non-linear multiplication of reward magnitude and probability to yield expected values. This feedforward mechanism enables generalization to novel choice options. Second, option values are compared within the recurrent network, where specific connectivity patterns mediate robust winner-take-all decisions, with both excitatory and inhibitory …

Artificial Sentience: The Other Side Of The Story, Amanda Sharkey

Animal Sentience

There is another side to the story of the account of artificial sentience — one that makes the possibility of artificial sentience unlikely: the fundamental difference between living bodies and artificial systems.  Sentience occurs in strongly embodied, living entities, and not in disembodied artificial systems, nor in robots. The appearance of sentience is exacerbated by deceptive behaviour and anthropomorphism. The risks of keeping an open mind about the required underlying substrate are in wasted efforts to protect systems that cannot suffer, and in placing inappropriate trust in their abilities.

Modulating Alternative Splicing Of Mecp2 Is A Potential Therapeutic Strategy For Rett Syndrome, Harini P Tirumala, Li Wang, Yan Li, Sameer S Bajikar, Ashley G Anderson, Wei Wang, Alexander J Trostle, Mahla Zahabiyon, Aleksandar Bajic, Jean J Kim, Hu Chen, Zhandong Liu, Huda Y Zoghbi

Faculty, Staff and Students Publications

Rett syndrome (RTT) is a neurological disorder caused by loss-of-function mutations in methyl CpG binding protein 2 (MECP2), a transcriptional regulator essential for maintenance of normal neuronal function. The current FDA-approved treatment for RTT, Trofinetide, mildly alleviates some symptoms. In contrast, re-introducing MeCP2 or increasing its amount through transgenesis in mouse RTT models improves most neurological phenotypes and enhances survival. Here, we devised a therapeutic strategy to moderately increase MeCP2 protein by modulating the alternative splicing of MECP2 to switch the less efficiently translated e2 to the more efficiently translated e1 isoform. We deleted Mecp2 exon 2 (unique …

Neuromodulating Mammals For Military Operations: Ethical Responsibility And Governance In Security Domains, Elise Annett, James Giordano

Strategic Insights

This commentary examines ethical and governance challenges associated with the potential use of neurotechnology to influence the behavior of marine mammals for military purposes. While the use of dolphins and sea lions in naval operations has historical precedent, reports suggesting that advanced neurotechnologies may be used to modulate or control the behavior of orcas represent a significant ethical and legal inflection point. Invasive neuromodulation techniques, such as implantable neural interfaces, pharmacological modulation, or remote stimulation raise serious concerns about animal welfare, agency, and the potential dual-use implications of neurotechnology. Stronger governance frameworks, including international dialogue, Department of War policy guidance, …

An Acetylation-Dependent Switch Underlies Host Disease Tolerance During Streptococcal Infection, Sumit Kumar Paudel, Sowmya Gannavaram, Michael G Caparon, Wei Xu

2020-Current year OA Pubs

Building on our finding that Streptococcus pyogenes pyruvate dehydrogenase (PDH) suppresses host disease tolerance (DT) via short-chain fatty acid (SCFA)-mediated modulation of host acetyl-CoA and IL-10 levels, we characterize the global transcriptomic and epigenetic mechanisms underlying this immunometabolic manipulation. Combining new histological and ultrastructural analyses with an in-depth re-analysis of single-cell and bulk RNA-seq datasets to more comprehensively characterize the DT response, we show that PDH deficiency is associated with broad immunologic rewiring, characterized by intracellular bacterial containment within phagocytes, expansion of pro-resolving myeloid cells, and altered cell-cell communication. Metabolic analysis of ΔPdh-infected tissues revealed a shift away from acetyl-CoA …

Glucagon-Like Peptide-1 Receptor Agonists And Risk Of Substance Use Disorders Among Us Veterans With Type 2 Diabetes: Cohort Study, Miao Cai, Taeyoung Choi, Yan Xie, Ziyad Al-Aly

2020-Current year OA Pubs

OBJECTIVES: To investigate whether initiation of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with both reduced risks of incident alcohol, cannabis, cocaine, nicotine, opioid, and other substance use disorders (SUDs) in people with no history of SUDs (protocol 1) and with reduced risk of SUD related adverse clinical outcomes among people with a pre-existing SUD (protocol 2).

DESIGN: Emulation of eight parallel, new user, active comparator target trials using electronic health records: seven trials for each incident SUD outcome (protocol 1) and one trial for adverse outcomes in people with pre-existing SUD (protocol 2).

SETTING: US Department of Veterans Affairs. …

Sodium Content Of Packaged Foods And Beverages In Nigeria: A Cross-Sectional Comparative Study With Who Global Sodium Benchmarks, Kenya, And South Africa, Adedayo E Ojo, Alexandra Jones, Kylie Howes, Vanessa Alfa, Anthony Orji, Oluwafemi A Stephen, Carla Pool, Alex Kibet, Fraser Taylor, Diederick E Grobbee, Bruce Neal, Mark D Huffman, Dike B Ojji, Sanne A E Peters

2020-Current year OA Pubs

High intake of processed foods, especially those with high sodium content, is a contributor to hypertension and cardiovascular disease. This study aimed to compare the sodium content of packaged foods and beverages in Nigeria to WHO Global Sodium Benchmarks and similar products in Kenya and South Africa. The study examined packaged foods from major retail stores in the capital cities of the Federal Capital Territory, Kano, and Ogun states in Nigeria from November 2020 to March 2021. Benchmark values were based on the 2021 WHO Global Sodium Benchmarks. We used secondary data from packaged food surveys conducted in South Africa …

An Ascendant In Scorpio: Dark Tourism In The Kingdom Of Cambodia, A Travelogue, Brenton Rossow

Research outputs 2022 to 2026

An eight-legged dark tourist with a freshly starched pith helmet, Sydney’s travels in Cambodia take him to the small town of Skuon, where people snack on fried tarantulas. The trip to Skuon, however, becomes more than just a tropical dark tourist tick box; instead, transforming into a sweaty pilgrimage into the crevices of Sydney’s ravaged psyche. During Syd’s journey, he must embrace his fears and ingest the beast within or forever wallow in the purgatory of his shadow self and its eternal torments. Caught in a web of vampiric arachnids, he must be careful not to become prey, tempted by …

Volume 12, 2025

James Madison Undergraduate Research Journal (JMURJ)

No abstract provided.

Nonfiction Runner-Up: Stuck In My Teeth, Grace M. Moore

Lindsay J. Cropper Creative Writing Contest

No abstract provided.

Nonfiction Winner: Shannon With Buckteeth, Annie With Dandelions, Annelise M. Klepper

Lindsay J. Cropper Creative Writing Contest

No abstract provided.

Michigan Tech’S Insect Collection: An Important Historical Resource In The Upper Peninsula, Thomas E. Panella, Tara L. Bal

The Great Lakes Entomologist

Regional insect collections can be valuable resources when covering under-represented areas, unique time periods, or unique collectors. Houghton and Baraga County Michigan are two predominantly forested counties in the Upper Peninsula (UP) of Michigan. The main campus for Michigan Technological University is based in Houghton, MI with a forestry field campus in Baraga County that was acquired in 1954. The university has had forest entomology research in some capacity at least since the 1930’s with faculty, students, and members of the community preserving and submitting various specimens in the decades since then, making it a unique collection demographically. The collection …

Dawn To Dusk Division Of Monarda Fistulosa Foraging Time By Bumble Bee Species (Bombus Spp.) And Likelihood To Return The Next Day, Elise Bernstein, Clara Costello, Mary Yang, Rosa Weinand, Noah Sullivan, Maya Cintorino, Charlie Vang, Miller Johnson, Ahmed Hussein, Gaochong Vang, Rashad Bowen, Kristen Gresl, Elaine Evans

The Great Lakes Entomologist

There is a growing public interest in increasing pollinator habitat in urban areas. Monarda fistulosa is a commonly planted perennial species chosen for pollinator habitats of various sizes, from residential gardens to large-scale prairie restoration projects. Previous research has confirmed a preference for M. fistulosa among various bee species. We monitored and marked bumble bees visiting M. fistulosa over a 14-hour period, seeking to understand the daily pattern of bee visitation. We also observed bumble bees on the following day to determine the probability of marked individual bumble bees continuing to forage on M. fistulosa or to switch to a …

Initial Changes In Ground Beetle (Coleoptera: Carabidae) Species Assemblages Near Seasonal Ponds Surrounded By Forests Under Different Harvesting Practices, Robert A. Haack, Toby Petrice, Robert E. Acciavatti, Robert L. Davidson, Brian J. Palik

The Great Lakes Entomologist

Seasonal ponds often form after spring snowmelt in forests of the Great Lakes region. Although such seasonal ponds are common, few US states set buffer-width guidelines to protect them when harvesting the adjacent upland forest. The objectives of this study were to determine if the carabid beetle assemblages near seasonal ponds differed from those in the adjacent upland forests prior to any logging, and then if these assemblages changed in response to various levels of tree harvesting within and adjacent to the 15-m-wide buffers that surrounded the seasonal ponds. The traps were placed within the buffers at about 7.6 m …

Biology, Phenology, And Host Range Of A Seed-Feeding Weevil, Ceutorhynchus Constrictus (Coleoptera: Curculionidae), A Biological Control Agent For Garlic Mustard, Alliaria Petiolata, In North America, Ghislaine Cortat, Hariet L. Hinz, Esther Gerber, Elizabeth J. Katovich, Mary E. Marek-Spartz, Roger L. Becker, Robert S. Bourchier, Danielle Fife

The Great Lakes Entomologist

Ceutorhynchus constrictus Marsham is a seed-feeding weevil and potential biocontrol agent of the invasive plant garlic mustard, Alliaria petiolata (Bieb.) Cavara & Grande (Brassicaceae), in North America. Ceutorhynchus constrictus is native to Europe, has a single generation per year and eggs are laid into developing seeds within the seedpods of bolting garlic mustard plants. Females use their prolonged rostrum to bore holes through seedpods into the developing seed, deposit a single egg and then cover the opening with secretion. Larvae feed on ripening seeds and progress through three instars before exiting seedpods in late June, to pupate and overwinter in …

Full Issue For Tgle Vol. 58 Nos. 3 & 4

The Great Lakes Entomologist

Full issue for TGLE Vol. 58 Nos. 3 & 4

The Authoritarian Semiotics Of The New Campus Mask Bans, Rob Kahn

St. John's Law Review

(Excerpt)

In 2024, students took part in protests for and against Israel’s military actions in Gaza. Some protests were disruptive and violent— most were not. In response, calls arose across the country to ban masks. In New York, a broad organization of civil rights groups called for a statewide mask ban under the hashtag #UnmaskHateNY, while New York Governor Kathy Hochul—with the support of New York City Mayor Eric Adams—called for a mask ban on the New York City subways. There were also calls in North Carolina and Los Angeles for new, or enhanced, mask bans. Meanwhile, Ohio’s Attorney General …

Freshwater Quality For Recreation, Heather Nix, Masha Bokar

Forestry and Natural Resources

South Carolina has many water resources that provide tremendous opportunities for people to enjoy water-based recreational activities, such as swimming, boating, and fishing. Participation in these activities produces significant economic benefits and supports many jobs throughout the state. However, at times, water quality may be unsafe for immersion or skin contact due to high levels of pollutants, such as bacteria or cyanotoxins. It is important for people to be aware of potential concerns and understand methods for determining if a waterbody’s current conditions are likely to be safe for primary or secondary recreation.

Combinatorial Therapeutic Strategies To Combat Multidrug-Resistant Acinetobacter Baumannii, Tope A. Aderibigbe

Theses and Dissertations

Acinetobacter baumannii is an opportunistic Gram-negative pathogen that poses a significant global health threat due to its remarkable ability to acquire multidrug (MDR) and extensively drug-resistant (XDR) phenotypes. Therapeutic failures are increasingly common as strains develop resistance to nearly all available antibiotics, including carbapenems, polymyxins, and tigecycline, leaving clinicians with limited treatment options. This study aimed to investigate combinatorial therapeutic approaches capable of revitalizing antibiotic efficacy against MDR/XDR A. baumannii clinical isolates. We evaluated the synergistic potential of durlobactam-sulbactam in combination with twelve commonly used antibiotics, including amikacin, rifampin, tobramycin, tigecycline, cefiderocol, and others. Initial screening using the disc diffusion …

March 2026 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate

Faculty Senate Packets

No abstract provided.

Rapid, Objective Verification Method For Convection Allowing Models Using Object-Based Storm Tracking, John David Goode

Research Horizons Day Posters

No abstract provided.

Counting The Recovery Of New Hampshire Bats, Mark Wanner

UNH Today Archive

No abstract provided.

Therapeutic Horsemanship For The Caregiver: Overview Of Results, Pinky Shani, Laura A. Espinosa, Rebecca Yarbrough

Creating Healthy Work Environments (CHWE)

Background: Healthcare professionals (HCPs) are prepared to care for illness and experience stressful situations including trauma and death. However, the overwhelming conditions during and after the pandemic can put many HCPs at risk of developing post-traumatic stress disorder (PTSD) and burnout. Previous research has reported a prevalence of PTSD among HCPs between 21.5% and 38% (Greene et al., 2021; Yan et al., 2021). In addition, 48% of ICU nurses experienced PTSD (Sanchez, Simon, & Ford, 2019). Furthermore, past research has indicated burnout levels of 55% to 86% among HCPs. It is essential that resources are provided for HCPs to cope …

Circulating Ketone Bodies And Incident Cardiovascular Outcomes And Mortality: Insights From The Uk Biobank, Parag Anilkumar Chevli, Saeid Mirzai, Richard Kazibwe, Jeff Kingsley, Alexis C Wood, Joseph Yeboah, Leandro Slipczuk, Anurag Mehta, Harpreet S Bhatia, Ambarish Pandey, Michael D Shapiro

Children’s Nutrition Research Center Staff Publications

Background: Ketone bodies (KB) are endogenous energy sources synthesized by the liver in response to metabolic stress. Their associations with atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), and mortality and their potential beneficial or harmful effects have yet to be determined. This study aimed to examine the association between KB and incident cardiovascular outcomes and mortality in a large general population cohort free from ASCVD and HF at baseline.

Methods: This analysis included 90 987 participants (mean age 56.4 ± 8.1 years; 54.7% women) from the UK Biobank without prevalent ASCVD or HF. KB were measured by nuclear magnetic resonance …

Vlx-1005, But Not Argatroban, Prevents Itam-Mediated Platelet Activation And Heparin-Induced Thrombocytopenia, Adriana Yamaguchi, Victoria Putzbach, Reheman Adili, Sophia Lazar, Livia Stanger, Devin Gilmore, David J. Maloney, Steven E. Mckenzie, James V. Michael, Michael Holinstat

Cardeza Foundation for Hematologic Research

Heparin-induced thrombocytopenia (HIT) is an immune prothrombotic disorder characterized by the binding of platelet-activating immunoglobulin G antibodies to platelet factor 4/heparin. In platelets, this leads to cross-linking of the immunoreceptor tyrosine-based activation motif (ITAM)-bearing receptor FcγRIIa, platelet activation, and thrombocytopenia, which in combination with extensive thrombin generation significantly increases the risk of thrombosis. Our laboratory has previously demonstrated that 12-lipoxygenase (12-LOX), an oxygenase primarily expressed in platelets, plays a critical role in platelet activation through FcγRIIa. In this study, we aimed to determine the effectiveness of VLX-1005, a potent and selective inhibitor of 12-LOX, alone or in combination with argatroban, …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Tubulin Transforms Tau And Α-Synuclein Condensates From Pathological To Physiological, Lathan Lucas, Phoebe S Tsoi, My Diem Quan, Kyoung-Jae Choi, Josephine C Ferreon, Allan Chris M Ferreon

Faculty, Staff and Students Publications

Proteins undergo phase separation to form membraneless condensates that spatially organize biomolecular interactions. These condensates can support cellular physiology or instigate pathological protein aggregation. Tau and α-synuclein (αSyn) are neuronal proteins that form heterotypic Tau:αSyn condensates associated with physiological and pathological processes. Tau and αSyn regulate microtubules, but also misfold and co-deposit in aggregates linked to neurodegenerative disease, highlighting the ambivalent impact of Tau:αSyn condensation in health and disease. Here, we show that Tubulin modulates Tau:αSyn condensates by promoting microtubule interactions and inhibiting homotypic and heterotypic pathological oligomers. In the absence of Tubulin, Tau-driven condensation accelerates formation of pathogenic Tau:αSyn …

Spartan Daily, March 3, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 17