Digital Commons Network^™

Formulation Strategies For Next-Generation Bispecific Antibodies: Design Considerations And Stability Implications, Priya Patel, Vaibhav D Bhatt, Nirav Patel

Bulletin of Faculty of Pharmacy Cairo University

Bispecific antibodies (BsAbs) represent a transformative class of next-generation biologics, enabling simultaneous binding to two targets and offering mechanisms of action beyond conventional monoclonal antibodies. Their growing clinical success, particularly in T-cell–redirecting therapies, has increased the need for robust formulation and Chemistry, Manufacturing, and Controls (CMC) strategies to support complex molecular designs, high potency, and multiple delivery routes. However, BsAbs present unique challenges due to structural heterogeneity, asymmetric domain interfaces, aggregation propensity, and sensitivity to physical and chemical stresses. This review provides a structured overview of formulation strategies for BsAbs, integrating molecular design considerations, developability assessment, and Quality by Design …

Usa V. Race Miner

2026 Decisions

USDC for the Middle District of Pennsylvania

The Indiana Statesman, August 27, 2026, Indiana State University

Student Newspaper

What to know about Emotional Support Animals; Annual street fair hits campus

Japanese Public Health Nurses' Culturally Sensitive Disaster Nursing In Islands - Focusing On Soc, Miki Marutani, Sagiri Aoki, Yukiko Anzai, Hiroko Okuda, Mayumi Kako, Susumu Fukita

International Nursing Research Congress (INRC)

Objective: Natural disasters are intensifying due to climate change. Sense of Coherence (SOC) enhances a community's resilience to disasters (Sutton et al., 2020). Public health nurses (PHNs) are required to enhance people's SOC to prevent health crises(Sofyana et al., 2022).Previous studies found that PHNs in islands recognized that while islands are vulnerable to disasters, they also possess a culture regarding disaster preparedness(Marutani et al., 2020) .This study identifies elements within the culture of remote islands, as understood by public health nurses, that align with SOC.

Methods：In 2023–2024, we conducted semi-structured interviews with seven PHNs on five islands regarding disaster-related culture. …

Economic Policies And Their Role In Enhancing Innovation: An Econometric Study Of South Korea (1996–2024), Ahmad M. Habeeb, Mahdi Saleh Sulaiman Al-Rikani

Muthanna Journal of Administrative and Economics Sciences

This research aims to study and analyze the impact of macroeconomic policies (fiscal, monetary, and trade) on promoting innovation in South Korea during the period 1996-2024 using the ARDL model. The results of estimating the model’s parameters in the short and long run showed a stable equilibrium relationship, with an error correction coefficient of –0.173. This indicates that the Korean economic system possesses a self-correcting mechanism that restores equilibrium shocks within approximately 5 years and 9 months. The results also demonstrated the importance of education spending and the money supply in stimulating and promoting innovation, while trade liberalization had a …

A Language We Built Together: A Physician Assistant’S Reflection On A Renal Transplant, Oviya Mahendran, Sampathkumar Sakthi Selvakumar

Journal of Wellness

This is not just a story of kidney transplantation in a tertiary care hospital in a tier-2 city of South India. It is all about a true clinical journey of resilience, where a young woman with congenital hearing loss, battling chronic kidney disease, discovered hope, understanding, and companionship through a physician assistant's compassionate communication.

Utah Vegetable Production Guide (5th Edition), Nick Volesky, Marion Murray, Amelia Olds, Bridger Carey

All Current Publications

This guide, written by a collection of Utah State University (USU) Extension faculty and specialists, provides information on general Utah vegetable production, soil, nutrient, and water management, integrated pest management practices, and pesticides. The included chapters cover various vegetable crops, including brassicas, cucurbits, leafy greens, potatoes, legumes, onions, root crops, sweet corn, and solanaceous crops.

Spartan Daily, August 27, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 167, Issue 04

Guided Tissue Regeneration Of Localized Deep Combined 2-To-3- Wall Angular Defects: A Clinical Case Report With 15-Month Follow-Up

Journal IDA

Periodontitis is a chronic inflammatory disease affecting nearly 50 percent of U.S. adults. It is characterized by the irreversible destruction of the alveolar bone, periodontal ligament, and gingival tissues supporting the teeth. Periodontal breakdown results from a dysbiotic relationship between the plaque bacteria and host-immune response. Initiated by the bacterial plaque biofilm, the once normal and homeostatic host defenses intended to contain the subgingival inflammation become dysregulated and hyperactive. A diagnosis of an infrabony defect, also known as intrabony, vertical, or angular defects, is made when the base of the pocket is apical to the alveolar crest. It has been …

Role Of Microsurgery In The Evolution Of Periodontal Surgery

Journal IDA

Microscopes and microsurgery techniques have revolutionized the field of periodontology, offering enhanced visualization, precision, and improved clinical outcomes. This review explores the role of magnification in periodontal treatments, the benefits of microsurgical techniques, and their impact on patient recovery and procedural success. It examines how these advancements align with evolving surgical principles and addresses their implications for clinical practice and patient outcomes. By integrating microsurgery into periodontics, clinicians can achieve minimally invasive procedures with superior aesthetic and functional results. This paper also discusses the challenges and future directions of microsurgical applications in periodontics, emphasizing the importance of continual advancements and …

Dental Sticky Situations

Journal IDA

Dentists dace ethical dilemmas in their clinical practice and in the daily running of their offices. These ethical situations are not always black and white or a choice between right and wrong. The truth is that most ethical situations facing dentistry are somewhere between the 256 shades of grey or differences between bad or worse and perhaps better and best.

Journal Ida 2025 104 3

Journal IDA

In the Summer 2025 issue, the reader will find the following feature articles:

• Dental Sticky Situations
• Defining Prescriptive Supervision and Delegation in Indiana: The Essential Roles of the Dental Hygienist and the Dental Assistant on the Dental Team
• Safeguarding Ethics: The Work of the Indiana State Board of Dentistry
• Dental Treatment: Who Has the Final Say on Oral Health Care?
• Overview of Indiana Health Records Law
• Ethical Considerations in Cosmetic Dentistry
• Protecting Dentistry’s Ethics: IDA’s Peer Review Program
• An Annotated Walkthrough of Dental and Dental Hygiene Professional Oaths Using AI Search Engines
• Radiation Safety in Dental Offices: Where Do We …

Journal Ida 2022 101 3

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2022 101 1

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2021 100 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2020 99 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2020 99 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2019 98 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2019 98 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Distribution Of Urinary Calculi And Its Association With Clinical And Laboratory Findings In Dogs And Cats With Stone Analysis At Chulalongkorn Animal Teaching Hospital, Thailand (2020-2024), Tanattha Ladabornvidhaya, Natkrita Baikloy, Theaparak Thipjaroen, Parapond Kongrakchang, Warisara Kaechaiya, Sumonwan Chamsuwan, Monkon Trisiriroj, Chollada Buranakarl

The Thai Journal of Veterinary Medicine

Urinary calculi are commonly encountered in veterinary practice; however, information regarding their distribution of stone that underwent analysis and associated clinical findings remains limited. This study investigated the distribution of urolithiasis and the associations between stone types and clinical and laboratory findings in dogs and cats presented to the Chulalongkorn Small Animal Teaching Hospital between 2020 and 2024. The three most common stone types in both species were calcium oxalate (CaOx), struvite, and urate, with relatively stable trends over the 5-year period. Small-breed dogs had a higher risk of developing CaOx urolithiasis than medium-breed dogs (OR = 10.4, 95% CI …

A Review On Traditional And Modern Aspects Of Vitex Negundo L.: Ethnomedicine, Phytochemistry, And Pharmacology, Tathagata Khanra, Suvasish Mitra, Subham Saha, Maitryee Mondal, Subhash C. Mandal

International Journal of Traditional Knowledge

Vitex negundo L., or five-leaved chaste tree, is a medicinally significant plant widely distributed in Asia and other tropical regions, frequently utilized in traditional healing systems for a spectrum of ailments. This comprehensive review consolidates current knowledge on the botany, traditional uses, phytochemical constituents, and pharmacological potentials of Vitex negundo L. The plant is rich in diverse bioactive compounds such as flavonoids, alkaloids, glycosides, and terpenoids, which are primarily responsible for its multidimensional therapeutic actions. Scientific investigations have substantiated its role in exerting anti-inflammatory, analgesic, antimicrobial, antioxidant, hepatoprotective, nephroprotective, insecticidal, anticancer, and antidiabetic effects, among others. Research reveals promising enzyme-inhibitory, …

Siddha Formulations: A Traditional Reservoir Of Valuable Medicines For The Contemporary World, Agnes Preethy

International Journal of Traditional Knowledge

Traditional Medicine had been practised for many centuries in different parts of the world. However, the deep insights drawn from the traditional knowledge have remained highly localized as it had been privy only to the generations of traditional medicine practitioners. This, combined with lack of scientific evidence of their therapeutic action, had limited access, acceptance and awareness of these preparations to the larger segment of the community. The emergence of new lifestyle disorders and drug-resistant diseases in recent years has fuelled the search for alternate treatment strategies and has revived interest in traditional medicines. Concerted efforts to decipher the molecular …

Ayurvedic Herbs In The Management Of Benign Prostatic Hyperplasia: A Comprehensive Narrative Review, Latha Damle, Chandrasekhar C

International Journal of Traditional Knowledge

Benign Prostatic Hyperplasia (BPH) is a common, non-cancerous enlargement of the prostate gland, primarily affecting older men. It frequently leads to lower urinary tract symptoms (LUTS) such as increased urinary frequency, urgency, nocturia, and weak urine flow, which can significantly impair quality of life. Standard treatments for BPH include alpha-blockers, 5-alpha reductase inhibitors, and surgical interventions. However, limitations in efficacy and potential adverse effects have driven interest in complementary and traditional therapies, including Ayurveda. In Ayurvedic medicine, BPH is described as Mutraghata and Vatashthila, conditions attributed to an imbalance of Vata and Kapha doshas that disrupt normal prostate and …

Unveiling The Night-Flowering Jasmine: A Comprehensive Review Of Nyctanthes Arbor-Tristis’ (Oleaceae) Phytochemistry, Ethnomedicine, And Therapeutic Potential, Subham Saha, Soumya Mitra, Tathagata Khanra, Saban Karmakar, Tamalica Hore, Subhash C. Mandal

International Journal of Traditional Knowledge

Nyctanthes arbor-tristis (NAT), typically known as Night-flowering Jasmine or Harsingar or Parijat, is one of the prominent medicinal plants indigenous to the Indian subcontinent. Its application dates back to ancient times, with substantial documentation in former religious texts. Native communities have traditionally used this for various human ailments and as an ornamental plant. Leaves, flowers, seeds and stems of this plant are rich in various primary and secondary metabolites, providing a wide range of pharmacological effects. The most abundantly found phytoconstituents belong to iridoid glycosides, such as arbortristosides. Comprehensive research has investigated its potential in anticancer, antiviral, and anti-inflammatory activities, …

Addressing Sustainability Challenges: Perspectives From Bhagavad Gītā, B Mahadevan, Dhrithi Mahadevan

International Journal of Traditional Knowledge

The industrialization-driven growth has ushered in economic progress over the past few centuries. However, it has also raised serious concerns about the sustainability of life on this planet. Despite considerable attempts to address sustainability issues using newer frameworks and efforts by corporates as well as governmental, and non-governmental institutions, we have remained ineffective in implementing sustainable solutions. The “last mile” to successfully implementing sustainable solutions is the individual. This calls for addressing individual values and aligning them to sustainability. This paper presents a fresh perspective on the problem by drawing some insights from the Bhagavad Gītā. We introduce the basic …

Agrarian Festivals Of India- Embedded Traditional Knowledge About Environment And Ecology Preserved Across Millennia, Lopamudra Maitra

International Journal of Traditional Knowledge

With a prominent agrarian economy, it is important to note the many agrarian festivals from across the nation. These festivals also help to highlight many rites, rituals and folklore, which forms the basic ethos of the celebrations and within the many layers of these are embedded knowledge about environment and ecology, which has been passed down through thousands of centuries. These have also been variously corroborated through archaeological, historical and epigraphical records of ancient India. This paper is an attempt to highlight this historicity of the agrarian festivals of India, which also corresponds to the mainstream festivals from across India, …

Gaining From Captured Indian Traditional Knowledge Systems: Paths Taken And Way Forward, Ramasami T

International Journal of Traditional Knowledge

India’s scientific heritage is deeply reflected in Ayurveda, a tradition of integrative medicine documented for over two millennia. P.C. Ray, the father of modern chemistry in India, highlighted the depth of ancient chemical knowledge and early use of mercury compounds, while M.S. Valiathan later revived and analyzed the classical texts of Charaka, Sushruta, and Vagbhata to bridge Ayurveda with modern science. Building on this foundation, the Government of India launched initiatives linking Ayurveda with genomics, personalized medicine, and rasayana therapies, yielding promising insights such as the genetic basis of prakriti classifications and protective effects of Amalaki Rasayana. Efforts like the …

Getting Money Out Of Politics By Putting Money Into Politics: A Few Modest Proposals To Reform Seattle’S Democracy Voucher Program, Decker O’Donnell

Seattle University Law Review

Seattle’s Democracy Voucher Program offers an unconventional response to the growing influence of money in American elections: rather than restricting political spending, it seeks to amplify the participation of ordinary voters by providing publicly funded vouchers that residents may assign to participating candidates. This Article examines the program’s development, operation, and constitutional foundation within the modern campaign-finance framework established by Buckley v. Valeo and subsequent Supreme Court decisions. It argues that democracy vouchers provide a constitutionally viable means of broadening participation in campaign financing while mitigating the influence of wealthy donors. The Article identifies two weaknesses in the current system: …

Retrieval Strategies For Embolized Left Atrial Appendage Closure Devices, Usama Sadiq, Muneeba Ali, Stacey Damito, Maxwell Ambrosino, Muhammad Sabri, Muhammad Ahmad Sadiq, Muhammad Hamza Sadiq, Richard Kovach, Sheena Rastogi, Muhammad Raza

Abington Jefferson Health Papers

BACKGROUND: Device embolization (DE) is a rare but potentially life-threatening complication of left atrial appendage occlusion (LAAO). As landmark trials broaden the eligible population for LAAO, operator preparedness for DE management becomes increasingly critical.

CASE SUMMARY: We present 4 cases of LAAO DE managed with distinct retrieval strategies: 1) open surgical retrieval with concurrent AtriClip ligation for an endothelialized left atrial device; 2) sequential transseptal then retrograde arterial snaring for intraprocedural migration to the abdominal aorta; 3) transseptal retrieval using a dedicated ONO system with cerebral embolic protection for partial left atrial dislodgment; and 4) retrograde large-bore arterial retrieval for …

Presence And Impact Of Herbicides On Intertidal Benthic Communities, Marco Sanderson

Electronic Theses and Dissertations

The growing reliance and widespread use of herbicides on a global scale is negatively affecting non-targeted biota and, consequently, their ecosystems. Herbicide levels and their impacts have been extensively researched around the world in riverine and lacustrine ecosystems. However, studies of the levels and effects of herbicides on coastal intertidal benthic communities have been lacking. This study focused on testing spectrophotometric methodologies for herbicides (atrazine and glyphosate) and documenting their presence and levels in sediment, water, and biotic tissue of intertidal coastal beaches and marshes of Waties Island and Singleton Swash, Horry County, South Carolina. A laboratory microcosm was employed …