Digital Commons Network^™

Gregor Samsa’S Pagkagimata (Awakening) In Bikol: A Becoming-Minor In Translation, Victor John M. Loquias

Akda: The Asian Journal of Literature, Culture, Performance

Kristian Cordero’s translation of Franz Kafka’s Metamorphosis instantiates what the philosophers Gilles Deleuze and Felix Guattari call minor literature. Preferring the Bikol term Pagkagimata—the literal event of Gregor Sama’s becoming-animal in the novel as title of the translation and the utilization of the Rinconada Bikol language for the transformed Samsa—Cordero has typified a perspective of translation that challenges the popular view of fluent translation from the source text to the target language. Exemplifying the concept of becoming-minor of Deleuze and Guattari and deploying Lawrence Venuti’s notion of the “remainder,” An Pagkagimata ni Gregor Samsa exhibits a deterritorialization of Bikol …

Narratives Of Dis-Ease: A Genre Study Of Pathography, Sylvelyn Jo A. Almanzor

Akda: The Asian Journal of Literature, Culture, Performance

This essay establishes pathography as a distinct genre of creative nonfiction, tracing the development, form, and cultural significance of this body of literature. I have broadly defined it as narratives on personal experiences of Gabriel Marcel's "dis-ease"—covering and critiquing the human understanding and experience of sickness, pain, and grief—which has evolved from autobiographical narratives and life-writing of patients and medical professionals to a recognized form of creative nonfiction. This study will analyze the genre's structure, themes, and rhetorical strategies with consideration to cultural significance and how it negotiates the human understanding of suffering, healing, and societal attitudes toward existence and …

Advancing Fish Tissue Reference Material Development For Ag Nanoparticles Through A Perfusion Approach, Nathaniel J. Clark, Robert Clough, Adam Laycock, Rachel Smith, Richard D. Handy

School of Biological and Marine Sciences

There is a regulatory need for reliable methods to quantify nanoparticles in biological samples for the hazard assessment and bioaccumulation potential of engineered nanomaterials (ENMs). Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) is a promising technique, but its application is hindered by the lack of validated sample preparation procedures (e.g., solubilisation) and suitable biological reference materials. This study aimed to develop an in-house biological reference material for ENMs to support analytical method validation. Silver nanoparticles (Ag NPs) were introduced into rainbow trout via cardiac perfusion, with the gills and liver collected as target tissues. Tissues were homogenised using a …

Sapientia Ex Machina: Engaging Ai As A Meaning-Making Tool For Philosophical Practice, Austin M. Pritchett

SPARK Symposium Presentations

This paper sets out to examine whether a Large Language Model can serve as a genuine interlocutor in philosophical inquiry. With a grounding in the phenomenology of Maurice Merleau-Ponty, and in conversation with other works in philosophy on AI, language, and the mind, the author determines the extent to which an AI's contributions to conversation can be said to participate in understanding and meaning-making rather than merely simulate it, thereby making evident the extent to which it is useful in philosophical practice.

Dark Wave - Comics And Transgender Studies In Practice, Mieke Vanderveen

Dartmouth College Master’s Theses

This is a thesis in two parts. Its goal is to provoke the intersection of superhero comics and transgender studies in order to interrogate the parallels between those two identities and explore ways in which pairing them together can strengthen each other narratively and academically. Rather than seeking an answer to a question, the project as a whole serves as a way of communicating trans internalities from a transfeminine perspective in a format that brings the issues to the forefront of the narrative in an in-depth and entertaining way. The result is hopefully a coherent artistic work that achieves those …

Detection And Quantification Of Allergen Cross-Contact In Shared Frying Oil Using Targeted Mass Spectrometry, Francisca Asigri

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Cow’s milk and egg allergies are prevalent IgE-mediated food allergies that pose significant public health concerns worldwide. Although strict avoidance remains the primary management strategy, unintended exposure can still occur through allergen cross-contact, particularly in commercial and industrial food operations that utilize shared frying oils. The objective of this study was to identify and quantify allergen transfer in shared frying oil and assess the robustness of existing targeted mass spectrometry methods (LC-MS/MS) for detecting milk and egg proteins in heated oil matrices.

Heated oil spikes were developed by incorporating non-fat dry milk (NFDM) and whole egg powder (WEP) into oil …

Assessment Of Precision Rangeland Management Tools In The Nebraska Sandhills, Hannah K. Allen

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

The objective of this thesis is to evaluate tools and management strategies that contribute to rangeland monitoring and livestock distribution in heterogeneous grassland systems of the Nebraska Sandhills. Chapter one reviews relevant literature related to precision livestock management, the Nebraska Sandhills, biomass estimation, and pyric herbivory. The second chapter evaluates the use of fractional green canopy cover (FGCC) derived from the Canopeo mobile application as a rapid method for estimating aboveground biomass in Sandhills rangelands. Biomass samples were collected across topographic positions in both early and late growing season, and relationships between FGCC and clipped biomass were assessed using generalized …

Comprehensive Profiling Of The Human Tear Fluid Mirnome Using Small Rna Sequencing, Garrett Jones, Drew Mayernik, Saleh Ahmed, Eliza Williams, Jeremy Altman, Tae Jin Lee, Amy Estes, Cintia S De Paiva, Pamela Martin, Shruti Sharma, Ashok Sharma

Faculty, Staff and Students Publications

Purpose: To generate a comprehensive profile of microRNAs (miRNAs) present in human tear fluid using next-generation sequencing (NGS), establish a reference miRNome for healthy human tear fluid, and investigate whether miRNA expression varies by sex, race, or age.

Methods: Tear samples were collected from 32 adults using Schirmer strips. RNA was isolated using the miRNeasy Serum/Plasma Kit, and cDNA libraries were prepared using the QIAseq miRNA Library Kit. Barcoded libraries were sequenced on the NovaSeq 6000 platform. Bioinformatic analyses included adapter trimming, alignment to miRBase, normalization with DESeq2, and functional annotation using multiMiR and clusterProfiler. Differential expression analysis was performed …

Effects Of Ethanol On Opg Expression, Osteoclasts, And Osteoblasts During Orthodontic Tooth Movement In Wistar Rats: An Experimental Study, Nadia Setiawati Widjaja, Ardiansyah S. Pawinru, Nasyrah Hidayati, Eddy Heriyanto Habar, Eka Erwansyah, Baharuddin M. Ranggang, Ita Purnama Alwi

Journal of Dentomaxillofacial Science

Objective: This research sought to assess how ethanol influences the expression of osteoprotegerin (OPG) and the number of osteoclasts and osteoblasts during alveolar bone remodeling associated with orthodontic tooth movement.

Materials and Methods: A laboratory-based experimental study was conducted using 30 male Wistar rats. Palatal movement of the maxillary incisors was induced using a nickel–titanium (NiTi) closed coil spring applied to the maxillary arch. Rats were randomly divided into two groups: a control group (CG) receiving orthodontic force only, and an experimental group (EG) receiving both orthodontic force and ethanol administration. Observations were conducted on days 0, 3, and 14. …

Semat: Semantic Enhanced Natural Image Interactive Matting, Ruihao Xia, Yu Liang, Peng-Tao Jiang, Hao Zhang, Qianru Sun, Yang Tang, Bo Li, Pan Zhou

Research Collection School Of Computing and Information Systems

Recent approaches attempt to adapt powerful interactive segmentation models, such as SAM, to interactive matting and fine-tune the models based on synthetic matting datasets. However, models trained on synthetic data fail to generalize to complex and occlusion scenes. We address this challenge by proposing a new matting dataset based on the COCO dataset, namely COCO-Matting. It selects real-world complex images from COCO and converts semantic segmentation masks to matting labels. The built COCO-Matting comprises an extensive collection of 36,980 human instance-level alpha mattes in complex natural scenarios. Furthermore, existing SAM-based matting methods extract intermediate features and masks from a frozen …

Electron Microburst Precipitation In Earth's Upper Atmosphere, Kelly Cantwell

Dartmouth College Ph.D Dissertations

Electron microburst precipitation can be a significant and prevalent source of electron loss from Earth's radiation belts into the upper atmosphere. This precipitation has been of interest since its discovery in the 1960's, and the continued progression of experimental capabilities has allowed for new and comprehensive analysis to be conducted on this phenomenon. The \af{barrel} mission was able to remotely sense microburst precipitation in both Northern and Southern hemispheres. In this thesis, I have written an automated detection algorithm with which 38 microburst events (with each event containing tens to tens of thousands of individual microbursts) were detected in the …

Mitochondria Dynamics In Microglia During Health, Inflammation, And Aging, Alicia Nicole Pietramale

Dartmouth College Ph.D Dissertations

Microglia continually surveil the brain, allowing for rapid detection of tissue damage or infection. Microglial metabolism is linked to tissue homeostasis, yet how mitochondria are subcellularly partitioned in microglia and dynamically reorganize during surveillance, injury responses, and phagocytic engulfment in the intact brain has remained unclear. In this dissertation, I combine intravital imaging, ultrastructural analyses, and metabolic and cytoskeletal markers to investigate how mitochondrial organization relates to microglial function across health, inflammation, and aging.

I first show that microglial processes diverge in their mitochondrial content, with some containing multiple mitochondria while others are completely void. This heterogeneous partitioning is conserved …

Lru Caching Policy Based On Naïve Bayes Ml Algorithm In Collaborative Peer-To-Peer Systems For Network Bandwidth Utilization, Waheed Yasin

Malaysian Journal of Computing (MJoC)

Web caching offers several advantages, such as increasing cache hit rates, lowering the workload on origin servers, and minimizing network traffic. Nevertheless, limited cache capacity poses a major challenge in web caching systems. Moreover, repeatedly fetching same media objects from origin servers leads to unnecessary bandwidth consumption. Furthermore, traditional caching policies, including Least Recently Used (LRU), are vulnerable to cache pollution. This study introduces a collaborative caching policy based on the Naïve Bayes (NB) Machine Learning (ML) algorithm. The proposed policy exploits structured peer-to-peer architectures, allowing cache contents to be shared among peers to improve the efficiency of LRU web …

Rates Of Aki And Evaluation Of Estimated Gfr In Covid-19 Patients, Jafar Alsalamy, Arif Malik

Iraqi Postgraduate Medical Journal

BackgroundCovid 19 was reported in Wuhan China in 2019, it is the third coronavirus infecting people from animals, increasing evidence indicate that coronavirus disease 2019 (COVID-19) is companied by renal dysfunction.ObjectiveTo evaluate the rate of acute kidney injury in patient diagnosed with covid 19 through serial evaluation of EGFR using the most accurate equation and serial changes in urine output and serum creatinine in order to elicit the diagnosis of acute kidney injury.Patients and MethodsOne hundred patients were randomly selected from isolation centers and consultation clinic and were followed in a period of 2 weeks and evaluated for the occurrence …

Mechano Responsiveness Of Neuroimmune Cross-Talk In Bone And Joints: A Narrative Review With Implications For Force-Based Manipulations, Karl J Lewis, Jennifer Bent, Per Gunnar Brolinson, Damian Keter, Ellen Lumpkin, Jan Mundo, Vitaly Napadow, William R Reed, Brent S Russell, Simon Y Tang, Mary F Barbe

2020-Current year OA Pubs

INTRODUCTION: Recent advances in osteoimmunology have illuminated the significant role of neuroimmune interactions in bone and joint health. The neuroimmune system critically regulates bone cell function through a complex network of molecular mediators - including signals from the sympathetic and parasympathetic nervous systems, pro- and anti-inflammatory cytokines, cortisol and other hormones, and growth factors. These mediators interact within a nonlinear network where each component can influence others reciprocally, with the brain serving as a central coordinator.

AIM: Our goal in this narrative review is to: 1) Provide an overview of roles the neuroimmune system is involved in bone and joint …

Leadership Communication Newsletter Spring 2026, Leadership Communication-Winona State University, Andrew Peine, Russell Zwiers, Miah Graczyk, Dorothy Moore, Robert Whisler

Leadership Education Newsletters

This is the newsletter created by the graduate students in the Leadership Communication 615 spring 2026 course.

Global Epidemiology Of Cephalopina Titillator Infestation In Camels: A Systematic Review And Meta-Analysis (1980–2025), Temesgen Mohammed, Aboma Zewude, Tsegaye Shamebo, Layaly Hamdan, Atef Oreiby, Hazim O. Khalifa, Gobena Ameni, Bojan Gajic

All Works

Background – Cephalopina titillator (C. titillator) is the causative agent of camel nasopharyngeal myiasis and is widespread in camel-rearing regions worldwide, causing impaired health, reduced productivity, and economic losses. However, despite the veterinary importance of C. titillator, global epidemiological evidence remains limited and fragmented, and no comprehensive synthesis of prevalence data across camel-rearing regions has previously been conducted. The objective of this review was to estimate the global pooled prevalence of C. titillator infestation in camels. In addition, subgroup analyses were made to assess the effect of camel species, geographic region, and study period on the pooled prevalence of C. …

A Critical Narrative Review Appraisal Of The 2025–2030 Dietary Guidelines: Scientific Strengths, Conceptual Gaps, And Overlooked Dimensions Of Sustainability And Health Equity, Dimitrios Papandreou, Azza Alsuwaidi, Zainab Taha, Constantinos Giaginis, Georgios K. Vasios, Eleni P. Andreou

All Works

The 2025–2030 Dietary Guidelines introduce an important shift in public health nutrition, emphasizing minimally processed foods, higher protein intake, greater inclusion of full-fat dairy, and a food-based advice centered on “real food” consumption. While several of these recommendations align with accumulating evidence, particularly the discouragement of ultra-processed foods and added sugars, substantial concerns remain regarding their internal coherence, population-level applicability, risk of misinterpretation, as well as environmental footprint. This critical narrative review evaluates whether the scope, emphasis, and framing of the new guideline components are proportionate to the strength, consistency, and context of the underlying evidence. Using a novel framework …

Metabolically Reprogrammed Eosinophils Impair T Cell Immunity And Cause Chronic Skin Infection, David Barinberg, Heidi Sebald, Tobias Gold, Baplu Rai, Daniel Radtke, Dominik Lerm, David Voehringer, Jonathan Jantsch, Stefan Wirtz, Alina Ulezko Antonova, Marco Colonna, Christian Bogdan, Ulrike Schleicher

2020-Current year OA Pubs

Eosinophils exhibit antimicrobial, cytotoxic and immunoregulatory effects, but our knowledge of their transcriptional and functional heterogeneity is still limited, especially in non-intestinal tissues. Here, we used a mouse model of chronic cutaneous inflammation elicited by the protozoan pathogen Leishmania mexicana to investigate the function and transcriptional dynamics of skin eosinophils. Infection of C57BL/6 mice triggered local and systemic eosinophilia that was driven by type 2 innate lymphoid cells and interleukin-5. Genetic and pharmacological eosinophil depletion led to an enhanced Th1 response, polarization towards M1-like macrophages and resolution of clinical disease, despite an unexpected simultaneous upregulation of IL-4. Single-cell transcriptomics revealed …

2026 All About The Dogs Packet, Carrie A. Finke

UNH Cooperative Extension

Join NH 4-H at the 28th annual “All About The Dogs” 4-H Dog Weekend Clinic, organized and run by the Rolling Bones 4-H Club. The goal is to provide a great fun-filled, canine training/themed weekend for youth enrolled in the 4-H Dog Program, or youth interested in joining. Youth will have the opportunity to learn new things, meet new people, visit old friends, get ready for the upcoming 4-H show season, and of course, have FUN with their dogs. Participants will get to experience activities and training seminars that they might not have the opportunity to see and experience through …

Nh Guide To 4-H Dog Shows, Extension

UNH Cooperative Extension

No abstract provided.

4-H State Horse Show Supporter Information, Extension

UNH Cooperative Extension

No abstract provided.

Tfeb Degradation Is Regulated By An Ikk/Β-Trcp2 Phosphorylation-Ubiquitination Cascade, Yan Xiong, Jaiprakash Sharma, Meggie N Young, Wen Xiong, Ali Jazayeri, Karl F Poncha, Ma Xenia G Ilagan, Qing Wang, Bei Gao, Hui Zheng, Nicolas L Young, Marco Sardiello

Center on Aging Staff Publications

Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and cellular clearance pathways. TFEB activity is tightly controlled by multiple post-translational mechanisms, but the exact molecular mechanism controlling its stability has remained elusive. Here, we identify the IκB kinase (IKK) complex as a key regulator of TFEB protein stability through a phosphorylation-ubiquitination cascade. A high-content kinase inhibitor screen reveals that IKK inhibition increases TFEB protein levels, and genetic ablation of IKK components increases TFEB stability, upregulates lysosomal genes, and enhances lysosomal biogenesis and degradative capacity. Mechanistically, we show that IKK phosphorylates TFEB on a cluster of serine residues …

Dietary Β-Hydroxybutyrate Sodium Alters Rumen Microbiome And Nutrient Metabolism In The Rumen Epithelium Of Young Goats, Yimin Zhuang, Guanglei Liu, Chuyun Jiang, Mahmoud M. Abdelsattar, Yuze Fu, Ying Li, Naifeng Zhang, Jianmin Chai

Animal Science Faculty Publications and Presentations

The role of β-hydroxybutyric acid (BHBA) includes providing energy, regulating signaling pathways, and ameliorating the gut microbiota in the host, while its nutrient mechanism to improve rumen epithelium development in young ruminants is still unclear. In this study, a total of 12 female Haimen goats with 30 d of age were chosen and divided into two groups. One group was fed with basic diet (CON), and the other group was fed a basal diet supplemented with 6 g d^–1 dietary β-hydroxybutyrate sodium (BHBA-Na). The experimental period was 30 d, and all goats were slaughtered at 60 d of age. …

Exchanging Genes Within A City: Analysis Of Pollen Flow Patterns In A Narrow Endemic Plant Species Threatened By Urbanisation, Nicola Delnevo, Andrea Piotti, Eddie J. Van Etten, William D. Stock, David L. Field, Margaret Byrne

Research outputs 2022 to 2026

Human-driven habitat fragmentation is known to disrupt gene flow in a wide range of species. However, its consequences for endemic plant species that depend on specialised invertebrate pollinators remain poorly understood. Although honeybees are capable of travelling considerable distances while foraging, many small-bodied native bee species lack the capacity to expand their foraging ranges or cross anthropogenic barriers, rendering habitat fragmentation the most significant threat to these ecological interactions. In many long-lived plants, the time since fragmentation has not been long enough for detectable changes in the genetic composition of standing populations. Changes in dispersal patterns observed in seedlings may …

April 2026, Office Of Research

Research Update

No abstract provided.

Visual Recognition Of The Anteroposterior Female Body Axis Drives Spatial Elements Of Male Courtship In Drosophila, Ross M Mckinney, Christian Monroy Hernandez, Yehuda Ben-Shahar

2020-Current year OA Pubs

Drosophila males exhibit a highly stereotypic courtship ritual toward virgin females, which is comprised of a sequence of specific behavioral elements that depend on inputs from diverse sensory modalities. Particularly, the visual system of the male plays an important role in detecting salient patterns, colors, and motion cues from conspecifics, which can promote or inhibit specific aspects of male courtship such as chase and song production. Here, we use a computer vision and machine learning-based approach, with a simplified courtship paradigm, to show that males also depend on visual cues to determine the anterior-posterior body axis of females, which drives …

Mda5-Mavs And Interferon-Lambda Signaling In The Intestinal Epithelium Limit Murine Astrovirus Infection, Heyde Makimaa, Harshad Ingle, Leran Wang, Somya Aggarwal, Hongju Deng, Elizabeth A Kennedy, Lynne Foster, Yuhao Li, Megan T Baldridge

2020-Current year OA Pubs

Human astroviruses (HAstVs) are a global cause of pediatric gastroenteritis and can cause disseminated infection in immunocompromised hosts. Murine astrovirus (muAstV) causes acute asymptomatic infections in immunocompetent mice and chronic infection in immunodeficient models and has provided important insights into AstV pathogenesis in vivo. MuAstV can protect immunodeficient mice from other enteric viruses via robust induction of antiviral cytokine interferon-lambda (IFN-λ), with recent findings implicating goblet cells and enterocytes as both cell types infected by muAstV as well as potential sources of IFN-λ in vivo. However, the viral sensing pathways that regulate induction of IFN-λ, as well as the specific …

Tfeb Degradation Is Regulated By An Ikk/Β-Trcp2 Phosphorylation-Ubiquitination Cascade, Yan Xiong, Jaiprakash Sharma, Meggie N Young, Wen Xiong, Ali Jazayeri, Karl F Poncha, Ma Xenia G Ilagan, Qing Wang, Bei Gao, Hui Zheng, Nicolas L Young, Marco Sardiello

2020-Current year OA Pubs

Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and cellular clearance pathways. TFEB activity is tightly controlled by multiple post-translational mechanisms, but the exact molecular mechanism controlling its stability has remained elusive. Here, we identify the IκB kinase (IKK) complex as a key regulator of TFEB protein stability through a phosphorylation-ubiquitination cascade. A high-content kinase inhibitor screen reveals that IKK inhibition increases TFEB protein levels, and genetic ablation of IKK components increases TFEB stability, upregulates lysosomal genes, and enhances lysosomal biogenesis and degradative capacity. Mechanistically, we show that IKK phosphorylates TFEB on a cluster of serine residues …

Preoperative Imaging For Cochlear Implantation: A Global Consensus, Farid Alzhrani, Craig Buchman, Et Al.

2020-Current year OA Pubs

OBJECTIVE: Preoperative imaging is vital for cochlear implant surgeries, aiding diagnosis, and surgical planning. This study evaluated global practices and the value of preoperative imaging through an international survey.

METHODS: A cross-sectional survey was conducted among international cochlear implantation experts using a 112-item questionnaire. The study explored imaging modalities, anatomical targets, evaluated parameters, and different imaging approaches' perceived value and risks. Participants were recruited from a global consortium of otolaryngology, otology, neurotology, and cochlear implant surgery professionals.

RESULTS: Thirty-nine practitioners from 36 centers in 16 countries completed the survey (95.1% response rate). All used computed tomography (CT) and magnetic resonance …