Digital Commons Network^™

Analyzing Antibody Immune Response In Α1,3galt-Ko Mice After Intranasal Vaccination Of Α-Gal Virus-Like Particle, Faith Brown

Honors Theses

In this study, we evaluated the immunogenicity of intranasal immunization with α-Gal-conjugated virus-like particles (VLPs) in an α1,3-galactosyltransferase-knockout (α1,3GalT-KO) mouse model that mimics the human immune response to the α-Gal epitope. The carbohydrate epitope galactose-α-1,3-galactose (α-Gal) is expressed on the cell surface of several pathogens, including Leishmania species. This molecule is absent in humans and has emerged as a promising immunogenic vaccine target. α1,3GalT-KO mice were intranasally immunized with 10 μg either Qβ-α-Gal or Qβ per nostril and boosted twice prior to sample collection. Blood and lung lavage samples were used to evaluate the antibody response. The Qβ-α-Gal group developed …

Effects Of “Zero Sugar” Energy Drinks On Microbial Proliferation In Relation To The Gastrointestinal Microbiome, Madison Hines

Honors Theses

Energy drinks have rapidly increased in popularity and availability in recent years. With the rise of high-caffeine beverages, complications due to caffeine consumption have become more common in younger populations. The aim of this study was to use controlled laboratory methods to determine the effect of energy drinks on a variety of organisms commonly found in the gastrointestinal (GI) tract. The diverse and dynamic nature of microbes in the gut makes conditions of the GI tract difficult to replicate in a laboratory setting. As an alternative, isolates of bacteria commonly found as normal flora in the GI tract were plated …

Evaluating The Environmental Parameters Impacting Spawning Movement Of Gulf Sturgeon (Acipenser Desotoi) In The Bouie River System., Olivia St. Germain

Honors Theses

The anadromous Gulf Sturgeon (Acipenser desotoi) is federally listed as “threatened” and is natal to seven rivers from Louisiana to Florida. Only one spawning reach for Gulf Sturgeon natal to the Pascagoula River has been verified via the collection of eggs and larvae; a reach of the lower Bouie River. This reach is anthropogenically modified by four gravel mining formations, hereafter referred to as pits. The greater depths associated with this area have prompted previous researchers to suggest that Gulf Sturgeon may over-summer in pit formations instead of migrating to downstream holding areas in the Pascagoula River after spawning. The …

Icarus’S Fall: Villainization In Wicked, Star Wars, And The Untamed, Laura Renfroe

Honors Theses

When looking back on the most beloved, yet infamous, villains of popular culture, one can note an abundant rise of prequels and backstory-driven media exploring the paths that villain characters take that lead them to their tragic fall. Some of those stories include John M. Chu’s Wicked, George Lucas’s Star Wars: Episode III: Revenge of the Sith, and Chen Jialin and Zheng Weiwin’s The Untamed, each of which explores protagonists who are labeled as “wicked” and depicted as fallen to the “dark side.” While these characters are often studied in existing literary research, there have yet to be explicit ties …

Bodies As Vessels: (Re)Production, Consumption, And Female Identity In The Handmaid’S Tale And Dawn, Shelby Clark

Honors Theses

This honors thesis examines how reproduction and food are used to signify power and impact female identity in Margaret Atwood’s The Handmaid's Tale and Octavia Butler’s Dawn. Both feminist dystopian novels portray societies that secure futurity through the commodification and management of women's domestic labor. The protagonist of each novel, Offred in The Handmaid's Tale and Lilith in Dawn, is responsible for ensuring the survival of humanity through forced reproduction and is additionally expected to produce or manage food. In this thesis, I argue that in both novels, female identity is reclaimed and affirmed as separate from a commodified state …

Subaltern Women, State Neglect, And Climate Precarity: Rethinking Forest Landscape Governance In Indonesia, Titiek Kartika Hendrastiti, Siti Kusujiarti

The Indonesian Journal of Socio-Legal Studies

This article examines the social positioning and struggles of subaltern women in East Java, Indonesia, within the intersecting conditions of state neglect and climate precarity in Forest Landscape Governance (FLG). Drawing on field research conducted between 2022 and 2023, it employs Postcolonial Feminist Political Ecology (PFPE) and Postcolonial Feminist Participatory Action Research (PFPAR) to analyze how governance regimes simultaneously depend upon yet marginalize women’s ecological labor. Based on field conversations, storytelling, focus group discussions, participatory drawing, and community dialogues in Banyuwangi and Trenggalek, the study shows that subaltern women remain largely invisible within formal governance frameworks, despite their central role …

Serological Evidence Of Borrelia Turicatae In Raccoons (Procyon Lotor) From An Endemic Focus Of Tick-Borne Relapsing Fever In Mexico, Jose A Hernández Martínez, Valeria Leal-Sepúlveda, Alan A Zavala-Norzagaray, Emilio Rendón-Franco, César P Ley-Quiñonez, Patricio Pellegrini-Hernández, Job E Lopez, J Antonio Ibarra

Faculty, Staff and Students Publications

Tick-borne relapsing fever is a neglected and overlooked disease. In Mexico, numerous historical reports document the distribution of Ornithodoros turicata, the vector of Borrelia turicatae, as well as human cases of infection. However, the enzootic cycle and reservoir hosts in Mexico remain unknown. Here, to detect previous infections with relapsing fever Borreliae in wild fauna a retrospective serological analysis was conducted with serum samples collected from raccoons trapped from 2022 to 2025 in the Navachiste region of Sinaloa, Mexico. Using a species-specific antigen, BipA from B. turicatae, and bacterial lysates of this spirochete, we found high exposure among this cohort …

Generative Artificial Intelligence With A Human Touch: Building Hana, Conrad Johnson

Faculty Scholarship

This Essay examines how generative artificial intelligence (GenAI) can be integrated into legal education and public interest law practice in a way that meaningfully enhances — rather than diminishes — human judgment, professional responsibility, and access to justice. Drawing on the experience of Columbia Law School’s Lawyering in the Digital Age Clinic, the Essay situates GenAI within an experiential pedagogy that emphasizes competence, ethical awareness, and collaborative problem-solving. It argues that law students and lawyers must move beyond a passive or uncritical use of GenAI tools; toward a deeper understanding of how these systems operate, the risks they pose, and …

Rexinoid Net-3ib Promotes Resident Macrophage Gene Expression And Mitigates Desiccation-Induced Ocular Surface Disease, Jehan Alam, Yangluowa Qu, Jianming Shao, Ebru Yaman, Karen Zheng, Hiroki Kakuta, Stephen C Pflugfelder

Faculty, Staff and Students Publications

Purpose: To evaluate the effects of rexinoid NEt-3IB on desiccating stress-induced dry eye, as well as monocyte/macrophage gene expression and cellular trajectory.

Methods: Eyes were topically treated with rexinoid NEt-3IB (5 µM) or vehicle three times a day for 5 days of desiccating stress-induced dry eye. Single-cell RNA sequencing (RNA-seq) profiled gene expression in conjunctival immune cells. RNA-seq was also used to evaluate gene expression in lipopolysaccharide (LPS)-stimulated, dexamethasone-treated (Dex, 1 µM), or NEt-3IB-treated (1-1000 nM) cultured monocytes. Cellular state trajectory and latent time were inferred with scVelo, and latent-time-associated genes were identified using Monocle 3. Permeability to Oregon Green-labeled …

Yield Of Injury Testing For Contacts Of Children Evaluated For Physical Abuse, Lígia Batista, Joanne N Wood, Tagrid M Ruiz-Maldonado, M Katherine Henry, Jan Leonard, Angela Bachim, James D Anderst, Farah W Brink, Hannah B Sahud, Lori D Frasier, Nancy S Harper, Natalie Laub, Colleen J Bressler, Daniel M Lindberg

Faculty, Staff and Students Publications

Background: Siblings and household contacts of physically abused children are at increased risk for physical abuse and may have injuries that are not clinically apparent. However, injury testing recommendations for contact children remain debated.

Objective: Our objective was to describe testing practices and yield for contacts of physically abused children.

Participants and settings: This is a cross-sectional study of children < 10 years old evaluated for physical abuse at 10 US pediatric referral centers in the CAPNET research network.

Methods: We report the proportion of contact children who had a skeletal survey (SS) or neuroimaging and describe the proportion of tests that identified injuries.

Results: Among 6256 index evaluations, 4863 contacts were identified. Among 794 contacts with physical examinations, …

Polyhydroxybutyrate (Phb) From Biofloc Systems Enhances The Growth And Immune Performance Of Genetically Improved Farmed Tilapia, Menaga Meenakshisundaram, Jimmy B. Mboya, Felix Sugantham

All Peer-Reviewed Publications

This study characterised polyhydroxybutyrate (PHB)-producing bacteria from the culture water of genetically improved farmed tilapia (GIFT) in biofloc ponds and investigated the influence of PHB on the growth and immune performance of GIFT. Out of 40 bacterial isolates, Bacillus infantis, Exiguobacterium profundum, Bacillus subtilis, Bacillus megaterium, Klebsiella pneumoniae and Enterococcus hirae showed positive results for PHB against fluorescent stains. The PHB yield in the range of 5%–95.45% (w/w) was recorded, with the highest from K. pneumoniae (95.45% w/w). The experimental treatments included a basal diet as a control (C), a basal diet with PHB (5 g kg⁻¹) from …

Croup: Dexamethasone Dosing, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

Film And Digital Arts Apr 2025 Self-Study Report & Documents, Unm Academic Program Review

UNM Academic Program Review

NM Film and Digital Arts APR self-study report, review team report, response report, and initial action plan for AY2025, fulfilling requirements of the Higher Learning Commission.

How Do Social Network Models Compare To All-To-All Models For Forecasting Tuberculosis Epidemics? A Mathematical Modeling Study, Masabho Peter Milali, Hae-Young Kim, George Corliss, Anna Bershteyn

Electrical and Computer Engineering Faculty Research and Publications

Background. Mathematical models guide tuberculosis (TB) target-setting, yet most assume homogeneous “all-to-all” mixing. We compared projected intervention impacts between an all-to-all compartmental model and a Barabási–Albert (BA) scale‑free social network model under otherwise identical disease assumptions.

Methods. We calibrated transmission parameters so both models produced similar baseline trends, then introduced vaccination (coverage 30–70%; efficacy 80–95%) and treatment (20–50% increases in recovery) after a 400‑day burn‑in. Outcomes were assessed 300 days post‑intervention.

Results. Under 60% coverage, increasing vaccine efficacy from 80% to 95% yielded smaller projected reductions in active TB with the network model than with all‑to‑all mixing. Treatment improvements showed …

Integrated Biotechnological Strategies For Planetary Health And Ecosystem Restoration, Duygu T. Yildirim, A. Baki Yildirim, Donald Martin, Tommaso Beccari, Oscar Vicente, Iza Radecka, Fideline Tchuenbou-Magaia, Robert Marks, Ratnesh Lal, Satya Prakash, Adam Mechler, Mario Petrov Milkov, Svetlana Fotkova Georgieva, Ilia Iliev, Radka Kaneva, Nuriye Gokce, Galina Aleksieva Yaneva, Nadya Vasileva Agova, Nikoleta Dobromirova Ivanova, Izem Olcay Sahin, Mariya Kiryakova Tsvetkova, Ivelin Rosenov Iliev, Michel Salzet, Kisung Ko, Michele Maffia, Matteo Bertelli, Isabelle Fournier, Lejla Pojskic, Qun Sun, Lembit Nei, Reynir Armgrisson

Research Outputs: 2025-Present

The escalation of ecological degradation, marked by climatic instability, precipitous biodiversity loss, and systemic chemical infiltration, necessitates a shift toward integrated biotechnological intervention. This analysis considers how the trajectory of diverse advanced methodologies, including environmental DNA (eDNA) surveillance, CRISPR-based genetic restitution, and synthetic biology-driven bioremediation, might be synthesized into a unified Planetary Health Framework. By exploring the convergence of high-precision genomic engineering, AI-augmented bioinformatic modeling, and the tenets of a circular bio-economy, we examine the capacity of technological intervention to ameliorate ecological stressors and restore critical ecosystems. Moving beyond the constraints of conventional conservation, this discourse explores frontier solutions in …

The Anchored: Issue 3, Spring 2026, Writer's Club Of The Hope-Western Prison Education Program

The Anchored

The Anchored is a quarterly publication of the Writer’s Club of the Hope-Western Prison Education Program.

Severity And Duration-Dependent Aortic Stiffening In A Rabbit Coarctation Model Identifies Constitutive Material Parameters As Promising Regional Biomarkers For Hypertension Progression, Arash Ghorbannia, Jamasp Azarnoosh, John F. Ladisa Jr.

Biomedical Engineering Faculty Research and Publications

Coarctation of the aorta (CoA) alters hemodynamics and drives regional remodeling, yet the influence of severity and duration on constitutive properties is undefined. We quantified mechanical responses from CoA to identify constitutive parameters capturing stiffening across clinical severities and durations. Mild (≤ 12 mmHg), intermediate (13–20 mmHg), and severe (> 20 mmHg) CoA was created in rabbits for short, long, and prolonged durations (~ 1, 3, or 22 weeks, respectively). Stress–stretch curves from proximal and distal regions were fit with multiple constitutive models (Linear Elastic, Neo-Hookean, Yeoh, Ogden, Mooney–Rivlin, Holzapfel). Model performance was evaluated by normalized RMSE and R², with …

Optimizing Duckweeds Harvesting Strategies To Maximize Nutrient Recovery And Its Role As A Phytosensor In Different Water Sources While Maintaining Sustainable Biomass Growth, Basma Ghannam

Theses

This thesis is concerned with determining the optimal water treatment and harvesting strategy for Lemna minor duckweed plants. The main objective of this thesis is to examine how duckweed plants grow in terms of biomass, photosynthetic activity, leaf morphology, chlorophyll and carotenoid content, and their efficiency in nutrient removal from different water sources. The methodology of the study included assessing duckweed in three water samples including tap water, saline water, and greywater and three harvesting strategies, including low, medium, and high harvesting intensities to assess their growth and nutrient removal efficiency. The results of the study showed that L. minor …

Effects Of Cross-Language Instructional Design On Foreign Language Learners' Cognitive Load: Approaching The Redundancy Principle Of Multimedia Learning, Leonor Mendiola Adams

STEMPS Theses & Dissertations

Because conceptualizations of cognitive resources play a critical role in determining the effectiveness of instructional design (Greeno, 2011; Greeno et al., 1996; Mayer, 2011, 2019), this study explores the effects of cross-language instructional design on learners’ perceived intrinsic, extraneous, and germane cognitive load content corresponding to content complexity, instructional presentation demands, and depth of understanding and schema construction, respectively.

Grounded in the redundancy principle of the Cognitive Theory of Multimedia Learning, this research further investigates whether the principle operates differently when learners’ native language is strategically incorporated into foreign language learning contexts. According to the cognitive theory of multimedia learning, …

Assessing Stakeholders’ Perceptions Of Organizational Effectiveness Through A Multidimensional Theoretical Model: An Interpretive Phenomenological Qualitative Case Study, Andrea M. Paul

School of Public Service Theses & Dissertations

Nonprofit organizations play a fundamental role in meeting community needs when government resources are limited or nonexistent. For decades, scholars and practitioners have recognized the importance of nonprofit-government partnerships for effective public service delivery. This study examines faith-based organizations as a specific type of hybrid nonprofit organization. As social, economic, and environmental challenges intensify, the need for community-based programs led by faith-based organizations also increases. These organizations are working to combat several of society's wicked problems, including but not limited to homelessness, food insecurity, drug addiction, youth and family services, and climate change. Nonprofit sector performance measurement is often recognized …

The Woah Global Wildlife Health Collaborating Centre Network (Woah-Wildnet): A Coordinated And Transformative Approach To Global Wildlife Health Challenges, David T.S. Hayman, Steve Unwin, Kelly Bateman, Casey Barton Behravesh, Charlotte Berg, Jemma Bergfeld, Cristina Casalone, Claire Cayol, Erin Davis, Sunday Ekesi, Johan Esterhuizen, Merid Getahun, Federica Giorda, Keith Hamilton, Damien O. Joly, Christa Kühn, Jean Claude Manuguerra, Daniel Masiga, Anita Michel, Paolo Mulatti, Misheck Mulumba, Annah Njui, Richard Paley, Antonio Fernández, Sascha Knauf, David P. Tchouassi, Youming Wang, Nathalie Vachiery, Jandouwe Villinger

All Peer-Reviewed Publications

Introduction Wildlife health is integral to functioning, complex ecosystems [1], directly and indirectly influencing the health of people, animals, plants, and the environment [2–4]. Healthy wildlife populations are essential for ecosystem services and are at the heart of the One Health approach [3,4], which aims to sustainably balance and optimize the health of people, animals, and ecosystems through multisectoral and transdisciplinary collaboration [5]. Despite its importance, wildlife health initiatives often operate in silos, limiting capacity to address transboundary threats such as emerging diseases, pollution, and environmental changes. Anthropogenic changes, including habitat loss, degradation, fragmentation, and unsustainable harvesting, exacerbate wildlife health …

Ai-Based Multi-Dimensional Coding Of Cancel Culture: Opportunities And Limits Of Llm-Based Categorization, Sairah Abraham, T. Andrew Poehlman

AMTP Proceedings 2026

Large-scale qualitative coding is a bottleneck in marketing research, especially for complex, multi-level phenomena like corporate cancel culture. This paper uses over 100 well-known cancellation events as a testbed to evaluate whether GPT can act as a reliable, low-cost “independent rater” for rich categorical schemes. We develop a multi-dimensional coding framework (trigger locus, controversy source, social issue, moral foundation, and target level) and implement a staged GPT pipeline: zero-shot prompts benchmarked against human “gold standard” coders, scaled to larger samples, then extended with few-shot prompting and fine-tuning for harder constructs such as moral foundations. We compare GPT variants and roles, …

Progesterone Dose Response Of Human Endometrial Stromal Fibroblasts, Paulina Chistoserdov

Undergraduate Honors Theses

This dissertation observes the effects of the steroid hormone, progesterone, on telomerase-immortalized human endometrial stromal fibroblasts in vitro, using a Luciferase assay. The methods leading up to the assay include doing a Midi-prep for plasmid isolation as well as plating, seeding (into a 96-well-plate), transfecting (with isolated plasmids), and exposing the fibroblasts to progesterone. The data produced was inconsistent across the three replicates, and the comparison ratios for Luciferase activity did not indicate any trends in progesterone dose response over increasing doses. However, when optimized, this project will be used as a baseline in the in vitro comparative system that …

Neural Progenitor Cell Proliferation In Response To A High-Fat Diet And Fgfr1 Inactivation, Alexandra Natalie Chistoserdov

Undergraduate Honors Theses

Tanycytes are radial glial-like astrocytes whose cell bodies line the third ventricle (3V) with long processes extending into the hypothalamic parenchyma. In adult mice, tanycytes retain stem cell properties, with their daughter cells integrating into the median eminence or mediobasal hypothalamus. Tanycytes are implicated in glucose homeostasis and appetitive behaviors not only via the maintenance of hypothalamic cell populations, but also by their glucose, fatty acid, and hormone-sensing capabilities. Fibroblast Growth Factor Receptor 1 (FGFR1) is a tyrosine kinase receptor expressed in neural progenitor cells, including tanycytes, where it induces cell proliferation and therefore plays an integral role in neural …

If Life Were Only As Our First Encounter, Yixiao Zhang

MFA in Visual Art

This thesis examines how contemporary portrait painting extends beyond the representation of physical appearance toward the construction of collective memory, history, cultural identity, and mechanisms of seeing. Using staged, photo-based portraits as a point of departure, my work engages both Eastern and Western traditions to produce new autoethnographic narratives. Rethinking the significance of portraiture today, this paper considers what persists and what has shifted over time. It argues that portrait painting is no longer merely a representation of an individual; rather, like a literary text, it functions as a signifier shaped by both the moment of its production and the …

Comparing Mercury Accumulation And The Macroalgal Microbiome Between Coastal And Estuarine Populations Of Sea Lettuce (Ulva Spp.), Shelby Cora Penn

Capstone Projects and Master's Theses

Mercury is a potent neurotoxin that bioaccumulates and biomagnifies in marine environments. Most research on mercury cycling in the ocean focuses on pelagic food webs, leaving a gap in knowledge regarding macroalgal-based food webs. Seaweed from the genus Ulva is globally distributed in marine and brackish habitats, accumulating metals and toxins with minimal impact on the host. While the mechanisms behind Ulva's tolerance to marine pollution are unclear, studies suggest that the macroalgal microbiome may play a crucial role. This study investigates how collection location influences mercury uptake and bacterial community composition in Ulva. Estuarine and coastal Ulva were exposed …

Preempting Pre-Approval: Clarifying Preemption Doctrine For Product-Liability Suits Against Brand-Name Drug Manufacturers, Nicholas G. Wallenburg

Vanderbilt Law Review

One of the most important issues for product-liability lawsuits against drug manufacturers today is federal preemption. Plaintiffs injured by prescription drugs regularly turn to state tort law for a remedy. Defendants in these cases—often brand-name drug manufacturers—frequently invoke preemption doctrine to argue that the Food and Drug Administration’s (“FDA”) rigorous approval process for prescription drugs has displaced state causes of action. While the text of the Food, Drug, and Cosmetics Act does not clearly address this issue, the U.S. Supreme Court has relied on a so-called “impossibility” theory of preemption: When a drug manufacturer cannot comply with the duties imposed …

Multiparametric Mri To Predict Response To Irreversible Electroporation Plus Anti-Pd-1 Immunotherapy In Pancreatic Ductal Adenocarcinoma, Qizhen Cao, Mark D Pagel, Charles V Kingsley, Jingfei Ma, James P Long, Xiaoxia Wen, Seth T Gammon, Jorge Delacerda, Sanaz Javadi, Chun Li

Faculty, Staff and Student Publications

Purpose: To investigate contrast-enhanced T1-weighted MRI and diffusion-weighted magnetic resonance imaging (DWI) for early prediction of tumor response to combined irreversible electroporation (IRE) and anti-PD-1 immunotherapy.

Methods: Murine pancreatic ductal adenocarcinoma (PDAC) cells KRAS* were inoculated into the pancreas of C57BL/6 mice. IRE was performed when tumors became palpable. After IRE, mice received six intraperitoneal injections of anti-PD-1 over 2 weeks. T2-weighted MRI, T1-weighted MRI with macromolecular contrast agent poly(L-glutamic acid)-conjugated gadolinium (PG-Gd), and DWI were performed before and after IRE. Survival was analyzed using Kaplan-Meier curves. Mice surviving at least 100 days without recurrence after IRE were considered complete …

Neutrophil-Microglia Interaction Drives Motor Dysfunction In A Neuromyelitis Optica Model Induced By Subarachnoid Aqp4-Igg, Fangfang Qi, Vanda A Lennon, Shunyi Zhao, Yong Guo, Husheng Ding, Caiyun Liu, Whitney M Bartley, Tingjun Chen, Claudia F Lucchinetti, Long-Jun Wu

Faculty, Staff and Student Publications

Neutrophils and neutrophil extracellular traps (NETs) contribute to early neuromyelitis optica (NMO) histopathology initiated by IgG targeting astrocytic aquaporin-4 (AQP4) water channels. Yet, the mechanisms underlying neutrophil recruitment and their pathogenic roles in disease progression remain unclear. To investigate molecular-cellular events preceding classical complement cascade activation in a mouse NMO model, we continuously infused, via spinal subarachnoid route, a non-complement-activating mouse monoclonal AQP4-IgG. Parenchymal infiltration of netting neutrophils containing C5a ensued with microglial activation and motor impairment but no blood-brain barrier leakage. Motor impairment and neuronal dysfunction both reversed when AQP4-IgG infusion stopped. Two-photon microscopy and electron microscopy-based reconstructions revealed …

Gompertz Growth With A Shared Carrying Capacity Optimally Simulates Primary And Metastatic Tumor Growth Dynamics, Pirmin Schlicke, Preethi Korangath, Xiaoxi Pan, Caner Ercan, Kathleen Gabrielson, Lyndsey Werhane, Yinyin Yuan, Sébastien Benzekry, Robert Ivkov, Heiko Enderling

Faculty, Staff and Student Publications

Background: Cancer is a systemic disease with most deaths attributed to metastatic burden. Primary and metastatic tumors, albeit at different anatomic locations, are interconnected through multiple biological processes. Pre-clinical and clinical observations of growth acceleration of metastases after surgery, or abscopal effects outside the radiation field are widely reported, yet reliably triggering favorable and avoiding unfavorable systemic responses remains an unmet clinical need. Understanding local and systemic tumor interaction dynamics will help guide future treatments.

Methods: We analyze the data of multiple in vivo tumor models. We formalize the systemic interplay of tumors as mathematical differential equation and calibrate parameters …