Digital Commons Network^™

A Cross-Species Meta-Analysis Of Environmental Enrichment Effects On Cognition, Greg S. Fitzgerald

Electronic Theses & Dissertations (2024 - present)

Environmental enrichment --providing animals or people with stimulating, complex surroundings --consistently improves cognitive performance in laboratory rodents. But when similar interventions are tested in humans, the benefits are much smaller. Understanding why matters: if researchers overestimate how well rodent findings will translate, it can mislead expectations for human cognitive interventions.

This dissertation presents the first cross-species meta-analysis comparing environmental enrichment effects on cognition between rodent and human studies. Drawing on 121 studies (71 rodent, 50 human) contributing 478 effect sizes, the analysis used multilevel models with variance correction to account for the statistical dependence created when studies report multiple outcomes. …

Providers' Perceptions Of Barriers And Facilitators To Implementing Non-Pharmacological Treatment For Adults With Chronic Pain: A Meta-Synthesis, Mikhaela Mcfarlin

Electronic Theses & Dissertations (2024 - present)

Background. Chronic pain is a public health concern impacting approximately 20% of adults in the U.S. Nonpharmacological interventions are considered first-line treatments for patients with chronic pain, yet nonpharmacological interventions remain significantly underutilized. While previous research has explored barriers from the patient’s perspective, limited attention has been paid to providers’ experiences implementing these treatments. This qualitative meta-synthesis aimed to examine provider-perceived barriers and facilitators to implementing nonpharmacolgical treatments for adults with chronic pain. Methods. Independent reviewers conducted systematic searches across PubMed, PsycInfo, CINAHL, and ProQuest Dissertations using relevant (e.g., “mental health provider”, “nonpharmacological”) and applied inclusion criteria to …

School-Based Interventions With Youth Engaging In Bullying Behaviors: Effective Strategies From The Perspective Of School Social Workers, Elizabeth A. Crowe

Electronic Theses & Dissertations (2024 - present)

Bullying is a nationally recognized social problem associated with harmful consequences for all youth involved. Despite their crucial role in bullying interventions and student success, the practices and perspectives of school social workers are notably absent from academic literature. This survey research study sought to identify strategies that school social workers use with youth engaging in bullying behavior; distinguish which strategies are the most and least effective from the perspective of school social workers; and recognize the supports and barriers school social workers face when implementing bullying interventions.

Survey data from a sample of school social workers answered these questions. …

Models Of Emulation: Representations Of Foreign, Indigenous, And Accented Speech In Early American Literature, Elaina A. Frulla

Electronic Theses & Dissertations (2024 - present)

“Models of Emulation: Representations of Foreign, Indigenous, and Accented Speech in Early American Literature” explores how American writers used depictions of “nonstandard” English and accented English language speech, traditionally described as “literary dialect,” as a way to negotiate identity, power, and political belonging in the formative years of nation building after the American Revolution. Beginning with Noah Webster’s mission to establish a standardized pronunciation of the English language that would simplify and purify spoken American-English and definitively differentiate it from what he saw as the corrupted, cosmopolitan British-English model, each of the three chapters examines literary representations of nonstandard emulated …

New Game Start: Playing With Power, Community And Change In Video Gaming Culture, Jonathan D. Muller

Electronic Theses & Dissertations (2024 - present)

Video gaming culture has long been a site associated with norms and values of whiteness, masculinity, and neoliberalism, with games, players, and developers all reinforcing these. Recently though, gaming culture has been directly involved with social movements and forms of resistance that are contrary to these norms and values. The typical gamer is no longer a white man, and gaming culture is now acknowledged to include race and gender dynamics that are close to that of the broader population. These communal shifts have both challenged and reinforced existing power structures. This research addresses these shifts and struggles by analyzing how …

Genetic Diversity Of Cryptosporidium Species In New York State, Kimberly A. Mergen

Electronic Theses & Dissertations (2024 - present)

The knowledge regarding Cryptosporidium infections in New York State (NYS) is severely lacking in two ways: 1) there are currently no NYS-based data regarding the subtypes of Cryptosporidium parvum and Cryptosporidium hominis, which are the two most prevalent species that infect humans and 2) information regarding uncommon Cryptosporidium species that infect the New York population is also unavailable. Filling these gaps concerning this pathogenic parasite would provide a substantial amount of information when considering public health, outbreak investigations, and prevention measures. Therefore, improving Cryptosporidium subtype and species surveillance in NYS will aid in prevention and control efforts as well …

Viral Diversification And Host-Specific Fitness Of Powassan, Heartland, And Bourbon Viruses In New York State, Rachel E. Lange

Electronic Theses & Dissertations (2024 - present)

This dissertation reports important progress for our understanding of emerging and re-emerging tick-borne viruses circulating in North America including Powassan, Deer Tick, Heartland, and Bourbon viruses. Chapter 2 describes important tools for these viruses including multiplex assays for viral and bacterial pathogens in field-collected ticks and mammals, development of full genome sequencing assays and bioinformatic pipelines for evolutionary analysis, and establishment of tick-specific tools for viral isolation and characterization. Chapter 3 focuses on the disease focality of Deer Tick virus, reporting transovarial transmission in nature in Ixodes scapularis for the first time, further evidence to incriminate shrews as potential Deer …

Emotional Factors Influencing Adaptive Memory: An Examination Of The Role Of Valence In The Survival Processing Effect, Dailyn Q. Clark

Electronic Theses & Dissertations (2024 - present)

Encoding information (e.g., words) in terms of their survival value produces enhanced recall relative to encoding the same information in terms of its value to other schematically similar situations (Nairne et al., 2007). In the survival memory paradigm, a scenario focused on imagining being stranded in the grasslands of a foreign land is followed by the rating of individual words (e.g., orange, mountain) as to their relevance to that scenario (Nairne et al., 2007). Using an incidental test of memory, it is often revealed that memory for those words is higher than for those same words encoded under non-survival, control …

Channel-Opening Kinetics Of Complex Kainate Receptors, Noah S. Saunders

Electronic Theses & Dissertations (2024 - present)

Ionotropic glutamate receptors (iGluRs) are found both pre- and postsynaptically in neuronal membranes, and mediate the majority of fast excitatory synaptic transmission in response to the binding of glutamate, a major excitatory neurotransmitter in the central nervous system (CNS). Ionotropic glutamate receptors are divided into three distinct subtypes: kainate, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and N-methyl-D-aspartic acid (NMDA) receptors. Auxiliary proteins specific to each receptor subtype also play a role in tuning both receptor expression and gating properties, such as neuropilin and tolloid-like (NETO) proteins that modulate kainate receptors, and transmembrane AMPA receptor regulatory proteins (TARPs) that regulate AMPA receptors. Like …

Rethinking Theories Of Political Discourse: The Limitations Of The Deliberative-Agonistic Split, Connor Moran

Electronic Theses & Dissertations (2024 - present)

What are “theories of political discourse,” why do they matter to political theory, and where do current ones fall short? This dissertation mines the existing resources availed by contemporary democratic theory in order to respond to the discursive challenge of “pernicious polarization,” particularly in the United States. The most comprehensive and influential theories of political discourse today have been furnished by the almost 40-year debate between deliberative democracy and agonism, both of which offer normative models centered on ameliorating the quality of political discourse.

The key finding of the dissertation is that the foundational works of the deliberative-agonistic split lack …

Multifunctional And Adaptive: Tracking How Fibroblasts Respond To Tissue Injury And Facilitate Tissue Remodeling, Joey R. Tavarez

Electronic Theses & Dissertations (2024 - present)

Fibrosis is characterized by an accumulation of proteins in the extracellular matrix (ECM) that results in altered tissue architecture and reduced organ function. In the salivary glands, fibrosis leads to loss of saliva, dysbiosis of the oral microbiome, an increase in oral infections, difficulty in digestion of food and an overall reduction in the quality of life. Understanding the progression of fibrosis and how it affects human health is a crucial step for designing effective therapeutics. Understanding fibroblast function is integral to advancing the field due to the many roles they play in maintaining the ECM. To perform preliminary analysis, …

German Science, American Manufacturing: Ethnic Capital, Transnational Technology, And Corporate Development At Bausch & Lomb, 1853–1953, George L. Grobe Iv

Electronic Theses & Dissertations (2024 - present)

This dissertation examines the first century of the Bausch & Lomb Optical Company, founded in Rochester, NY in 1853 by German immigrants John Jacob Bausch and Henry Lomb. It argues the firm’s success was driven by leveraging of management’s German ethnic identity as “ethnic capital” to access resources like financial liquidity, immigrant labor, and technical expertise. These resources allowed for the transformation of the firm from a small optical retail shop into a major manufacturer of advanced optical instruments. However, as later generations of the family Americanized, the ability of the firm to leverage ethnic capital eroded until breaking completely …

Barriers And Corridors: Timber Rattlesnake Habitat Connectivity In New York, Lauren Rose

Electronic Theses & Dissertations (2024 - present)

Habitat fragmentation poses a significant threat to species that rely on landscape connectivity for movement in search of food, water, and mates. The timber rattlesnake (Crotalus horridus), listed as a threatened species in New York State, travels an average of 1.5 miles—and up to five miles—from permanent denning sites to reach habitat suitable for gestation, foraging, basking, and overwintering. Ongoing development in the lower Hudson Valley has increasingly fragmented these critical habitats, restricting movement between den populations. This thesis evaluates landscape barriers that contribute to population isolation and identifies opportunities to restore connectivity among timber rattlesnake metapopulations.

Using …

Inflammation In Early Borrelia Burgdorferi Skin Infection, Ariana Nobles

Electronic Theses & Dissertations (2024 - present)

Borrelia burgdorferi (Bb) is the causative agent of approximately 476,000 cases of Lyme disease in the United States and rising. Bb is spread through infected saliva of the black-legged tick, Ixodes scapularis, to the host. Patients infected with Bb experience short-term symptoms, such as erythema migrans (EMs), fatigue, pain, and cognitive impairment. If left untreated, Bb infection will cause long-term health complications, like Lyme neuroborreliosis and Lyme arthritis. It is postulated that symptoms associated with Lyme disease are driven in part by inflammation.

My thesis focuses on the skin as it holds significant immunological importance in the …

Becoming-With The Earth: Contemplative Practice As A Critical Onto-Epistemic Resource For Planetary Belonging, Care, And World-Making, Megan M. Fowler

Electronic Theses & Dissertations (2024 - present)

In an era of accelerating planetary crisis, social work is called to reimagine its theories, methods, and practices beyond anthropocentric frameworks that separate human wellbeing from the health of the Earth and its resplendent living systems. Working in the space of transformative eco-social work, a growing chorus of voices contends that eco-centric responses require broadening the scope of health, welfare, justice, and care to extend beyond the human, to include the more-than-human world upon which all life intimately depends—understandings resonant with Indigenous and other relational knowledge systems long marginalized by colonialist-capitalist-modernity. Drawing from eco-feminist, eco-queer, decolonial, and post-anthropocentric lineages of …

Perceptions Of Psilocybin-Assisted Psychotherapy And Standard Interventions For Nicotine Cessation, Philip Kamilar-Britt

Electronic Theses & Dissertations (2024 - present)

Clinical trials suggest potential therapeutic utility of psilocybin-assisted psychotherapy (PAP) for nicotine cessation. In response to promising outcomes, research into PAP for nicotine dependence is growing. However, attitudes towards PAP among the general public, especially daily nicotine users, remains understudied. To address this knowledge gap, we recruited daily nicotine users (N=534) to complete an anonymous online survey with questions on demographics, nicotine use, prior history with psychedelics, and attitudes towards PAP and standard interventions for nicotine cessation. As hypothesized, daily nicotine users were more familiar with standard interventions and rated them more favorably than PAP. Despite differences in treatment attitudes, …

When Helpfulness Becomes Harmful: Jailbreaking Llms For Malicious Code Generation, Noelle Capodieci

Electronic Theses & Dissertations (2024 - present)

Generative AI (GenAI) and Large Language Models (LLMs) have made large strides in coding task capabilities, with many software developers integrating agentic engineering into their workflow. While GenAI has largely benefited professional software engineers who can automate their work, it has also created room for those with little coding expertise to also create fully fledged programs and applications. It is commonly noted that GenAI is trained with two major goals in mind: to be as helpful as possible, and be as harmless as possible. There exist moments where helpfulness may be prioritized over harmlessness when these goals conflict. LLMs may …

De Novo Protein Binding To Zinc Oxide Through Biomineralization Pathways, Jean-Mark A. Francis

Theses and Dissertations

De novo proteins are structurally distinct from proteins found in nature and thus capable of having their amino acid sequence modified to accomplish tasks such as increasing protein-nanoparticle binding without unfolding or decomposing. Zinc Oxide nanoparticles are functionally distinct from their bulk counterparts and are widely used as semiconductors in a variety of fields such as medicine and agriculture. With demand for these nanoparticles increasing, environmentally sustainable methods of Zinc Oxide nanoparticle synthesis are being investigated as an eco-friendly alternative to currently utilized but environmentally hazardous chemical and physical techniques. This research investigates the binding characteristics between Zinc Oxide nanoparticles …

Commissioning & Daily Qa Of Converted Linac For Electron Flash, Tomaj Javidtash

Theses and Dissertations

Ultra-high dose rate (FLASH) radiotherapy has demonstrated promising normal tissue sparing in preclinical studies; however, the lack of standardized dosimetry, commissioning, and quality assurance (QA) methodologies remains a major barrier to its reproducible and safe implementation. In particular, conventional clinical commissioning and QA protocols are not directly applicable at FLASH dose rates due to challenges associated with detector response, dose-per-pulse effects, and beam control limitations.

This thesis presents the commissioning of a converted Varian 21EX linear accelerator for electron FLASH operation within the Division of Medical Physics at the Virginia Commonwealth University (VCU) Department of Radiation Oncology. Comprehensive beam characterization …

Staging Violence With Intentionality, Toby O'Brien

Theses and Dissertations

This thesis examines the role of the fight choreographer in the theatre while addressing the potential issues staged violence has in distracting an audience from the intended narrative of the play. Avoiding the instruction manual approach of stage combat in favor of expounding on the theory of violent entertainment, I have constructed a thesis that informs the reader of certain types of violence found in both classical and modern productions and have researched the psychological ramifications of violent spectatorship and the necessity for content acknowledgements as well as consideration for the performer’s well-being. By exploring the history of violent entertainment …

Gz17.602, A Combination Of Three Nutraceuticals, Interacts With Carboplatin And Etoposide To Kill Neuroblastoma, Michael R. Booth

Theses and Dissertations

This study examined the efficacy of GZ17.602, a combination of Harmine, Isovanillin, and Curcumin as a therapeutic for MYCN-amplified Neuroblastoma, both alone and in combination with standard of care chemotherapeutics. This was done due to the low survival rate associated with these neuroblastomas, the large degree of morbidity associated with current treatments, previous experiments in the Dent lab having shown 602 as effective for killing cancers of other types, and the current lack of understanding of the biology of GZ17.602 in solid pediatric cancers. Due to the GZ17.602 components being present at different concentrations in tumors than those administered, the …

An Integrated Data-Driven Framework For Arctic Shipping: Analyzing Vessel Speed, Environmental And Ecological Factors Through Innovative Statistical Spatio-Temporal Methods, Inverse Optimization And Machine Learning, Mauli Pant

Theses and Dissertations

This dissertation develops an integrated data-driven framework to analyze vessel navigation and ecological risk in the United States Arctic from 2010 to 2019. As environmental change and maritime activity increase in the region, understanding how vessels respond to dynamic conditions and how those responses interact with marine ecosystems has become increasingly important. A central theme of this dissertation is the treatment of vessel speed as both an observed outcome and a decision variable reflecting trade- offs among operational, environmental, and ecological factors. The first chapter develops a predictive framework for vessel speed over ground (SOG) using Gaussian Process Boosting (GPBoost), …

Pingbongbilladingdong: Abjection And Comedy In Art, Leroy A. Winter

Theses and Dissertations

As of late, my work has dealt with themes of collapse and comedy, pertaining specifically to faded ideals of individualism in art. My thesis installation, titled Pingbongbilladingdong, is a testament to this tension, portraying a reconstruction of the disheveled chaos of the artist’s studio. In this paper, I use this installation as a means to further explore the ways that abjection and comedy intersect in art, and how myself and others repurpose the faded glamor of Ab-Ex as a means to probe this overlap. Serving as an allegory for my experience with the studio, Pingbongbilladingdong presents an image of the …

The Ethereal Being That Is Me, And Maybe You, Hwiy Chang

Theses and Dissertations

The Ethereal Being That Is Me, and Maybe You is a 23-minute video collection of short stories accompanied by an installation at the Institute for Contemporary Art at Virginia Commonwealth University. This thesis explores the work’s creation as a visual and narrative meditation on self-transformation, drawing from personal experiences in therapy and philosophical texts including Carl Jung’s concept of the unconscious. The paper examines how each story represents a distinct stage of transformation—from recognizing patterns to confronting setbacks to reshaping internal dialogue—and how watercolor’s fluid, unpredictable nature serves as a visual metaphor for the process of change. The installation component …

My Mouth Is A Glutton, My Mouth Is A Lover., Cole Kamerick Eller

Theses and Dissertations

This thesis is a reflection on my relationship with jewelry. I discuss the impact of jewelry

and its materials. What are the ramifications of these objects? Politically, socially, and

spiritually. I reflect on material agency, cultural unconscious, and value systems, and

how I relate to jewelry, my love for it, and my grief for it. This work is the result of ritual

and impulse. The writing is my reflection on the results of that ritual.

Daisyworld, Eva Foldy

Theses and Dissertations

Daisyworld explores how painting can represent ecological and sociopolitical crisis without relying on narratives of total collapse as a catastrophic end, instead framing the present as a condition of ongoing, uneven transformation. Drawing on ecological models of adaptation, interdependence, and planetary self-regulation, it uses plant fasciation as both a biological reference and speculative metaphor for distorted yet generative forms of survival. Situating painting within a broader history of visual culture, it examines how images function as accessible systems of knowledge while challenging colonial and human-centered modes of representation. In dialogue with contemporary, systems-based artistic practices, the project repositions painting as …

Absolute Quantification And Identification Of Rna From Rna-Lipid Nanoparticles Using High Resolution Mass Spectrometry, Jason C. Funderburk

Theses and Dissertations

RNA therapeutics are a rising drug category with potential use for a range of conditions encompassing infectious diseases to therapies for cancer, diseases, and genetic disorders. RNA-lipid nanoparticles (RNA-LNPs) are the prominent delivery method for these therapeutics approved products include mRNA vaccines and polyneuropathy treatments. The emergency use authorizations and orphan drug status of current RNA-LNP drugs has allowed approval without finalization of the regulatory analytical procedures for quality monitoring. The objective of the study was to develop an LC-MS assay to simultaneously measure identity and concentration of two therapeutically relevant intact RNA constructs extracted from RNA-LNPs to enhance quality …

Walking And Wondering, Helen T. Tran

Theses and Dissertations

My thesis approaches walking as a form of inquiry and the Flood Wall as a site open to reinterpretation. I believe that the way we walk changes the way we observe and experience the world around us. This contrast between purposeful and leisurely walking reveals how time and intention shape our awareness of space. When walking is no longer dictated by urgency, it invites observations and questions. Slowing our pace allows curiosity to emerge, which aligns with my design ethos of asking questions as a foundation for understanding and creating meaningful experiences.

The Flood Wall’s emphasis on uninterrupted movement prioritizes …

There Is A Puddle In Stonehenge, Nathaniel Newcomb

Theses and Dissertations

I began by making what I called "furniture": finding discarded logs and using a chainsaw, I milled out slabs of wood far larger than any normal board or beam, and gave them the function of chair, table, shelf. Sometimes it was a "shelf" in name only, and was commentary on furniture. In my practice, using discarded wood is necessary for the sake of the earth; making original pieces is necessary for the sake of my soul. I am reminded of megaliths when I erect these enormous forms in wood. I make intuitively, and like the meaning of megaliths, obscured by …

Film For Jeanette, Brice Goldberg

Theses and Dissertations

Film for Jeanette is an experimental documentary concerning grief, memory, and what remains of those who have left this physical plane. The film paints the portrait of my late sister, Jeanette Lee Goldberg, who died in a car accident when she was 19. What begins as a memorial becomes a celebration of her life and an exploration into the complexities of her character that led to her death. Jeanette’s story is told through interviews with family members, while the visuals, created with various alternative 16mm film techniques, depict my own journey through the filmmaking process. I was only 3 when …