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2026

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Integrating Nutrition And Stress Into Life History Stages Of Wild Free-Ranging Female Pronghorn, Cole A. Bleke, Eric M. Gese, Juan J. Villalba, Shane B. Roberts, Susannah S. French Jul 2026

Integrating Nutrition And Stress Into Life History Stages Of Wild Free-Ranging Female Pronghorn, Cole A. Bleke, Eric M. Gese, Juan J. Villalba, Shane B. Roberts, Susannah S. French

Wildland Resources Student Research

Studies addressing seasonal changes in diet quality and hormones are important for understanding the interactions between ecology and physiology. We collected fecal samples from free-ranging adult female pronghorn (Antilocapra americana) to examine the relationships between indicators of nutrition and glucocorticoid activity. This occurred during three population-level, life-history-correlated sampling periods across five subpopulations. We evaluated nutrition via fecal nitrogen, fecal 2,6-diaminopimelic acid (DAPA), and assessed glucocorticoid activity using fecal glucocorticoid metabolites (FGM). We found positive relationships between fecal nitrogen and DAPA, whereas DAPA and fecal nitrogen with FGM varied in influence and strength, depending upon life history stage. Generally, …


Evaluating Cardiotoxicity And Factors Associated With In-Hospital Mortality Among Emergency Department Patients With Substance Use Disorder: An 11-Year Retrospective Study, Darpanarayan Hazra, Nadia Ahmed Said Alqusaimi, Alyaqeen Ahmed Abdullah Al Breiki, Raghad Saleh Mohammed Al Akhzami, Aya Hasan Hadi Aalhamad, Suad Abdullah Al Abri Jul 2026

Evaluating Cardiotoxicity And Factors Associated With In-Hospital Mortality Among Emergency Department Patients With Substance Use Disorder: An 11-Year Retrospective Study, Darpanarayan Hazra, Nadia Ahmed Said Alqusaimi, Alyaqeen Ahmed Abdullah Al Breiki, Raghad Saleh Mohammed Al Akhzami, Aya Hasan Hadi Aalhamad, Suad Abdullah Al Abri

Sultan Qaboos University Medical Journal

Objective: Substance use disorder (SUD)-related emergencies are increasing globally, with cardiotoxicity contributing substantially to morbidity and mortality. This study evaluated cardiotoxicity patterns and factors associated with in-hospital mortality among adults with SUD presenting to the emergency department (ED).Methods: This retrospective observational study was conducted from January 2014 to December 2024 at Sultan Qaboos University Hospital, University Medical City, Muscat, Oman. Adults aged ≥18 years with SUD and positive urine drug screening (UDS) were included if they had elevated troponin (>14 ng/L), electrocardiographic abnormalities or echocardiographic structural dysfunction. Clinical, laboratory, imaging, management and outcome data were analysed. Results …


Research And Innovation Update, July 8, 2026, Office Of The Vice President For Research And Innovation Jul 2026

Research And Innovation Update, July 8, 2026, Office Of The Vice President For Research And Innovation

Office of Research, Economic Engagement and Outreach

No abstract provided.


Tgf-Β Drives The Conversion Of Conventional Nk Cells Into Uterine Tissue-Resident Nk Cells To Support Murine Pregnancy, Josselyn D Barahona, Liping Yang, D Michael Nelson, Wayne M Yokoyama Jul 2026

Tgf-Β Drives The Conversion Of Conventional Nk Cells Into Uterine Tissue-Resident Nk Cells To Support Murine Pregnancy, Josselyn D Barahona, Liping Yang, D Michael Nelson, Wayne M Yokoyama

2020-Current year OA Pubs

Tissue microenvironments shape lymphocyte differentiation to align immune function with local physiological demands. Uterine natural killer (NK) cells are critical for reproductive success, yet the molecular cues in the uterus that instruct their specialized identities remain incompletely understood. Here, we identify a TGF-β-dependent differentiation pathway by which circulating conventional NK cells convert into uterine tissue-resident NK cells during murine pregnancy. Loss of TGF-β receptor II expression in


Toward A Private Law Of Intimates' Obligations, Emily J. Stolzenberg Jul 2026

Toward A Private Law Of Intimates' Obligations, Emily J. Stolzenberg

Faculty Publications

When former cohabitants ask courts to distribute property at the end of a nonmarital relationship, they usually lose—even when the partners were as economically intertwined as spouses. Family law scholars have traditionally criticized these cases in terms of longstanding gendered ideas about family relationships. This Article proposes a complementary account at the intersection of feminist and private law theory: that the law of voluntary obligations is not adequately developed to protect intimates’ cooperation. Although marital status law aims to safeguard thick cooperation between spouses and contract law captures a range of more market-based cooperation, for historically contingent reasons, little doctrine …


Upar-Guided Dendrimer Gel Nanoparticles Reprogram Inflammation To Stabilize Atherosclerotic Plaques, Hsin Yin Chuang, Huari Kou, Yue-Wern Huang, Hu Yang Jul 2026

Upar-Guided Dendrimer Gel Nanoparticles Reprogram Inflammation To Stabilize Atherosclerotic Plaques, Hsin Yin Chuang, Huari Kou, Yue-Wern Huang, Hu Yang

Biological Sciences Faculty Research & Creative Works

Atherosclerosis is characterized by lipid deposition, chronic inflammation, and apoptosis within the arterial wall, leading to plaque progression and instability. Current lipid-lowering therapies fail to fully address residual cardiovascular risk driven by local inflammation and cell death. Here, we report the development of uPA-functionalized, rapamycin-encapsulated dendrimer nanoparticles (G5PM-uPA/RA) that preferentially accumulate in urokinase plasminogen activator receptor (uPAR)-enriched atherosclerotic plaque, including macrophage- and apoptosis-rich lesion microenvironments. G5PM-uPA/RA was constructed by cross-linking reaction-enabled flash nanoprecipitation in a custom-made multi-inlet vortex mixer, followed by thiol-maleimide conjugation of uPA for uPAR-guided targeting. The nanoparticles demonstrated uniform morphology, favorable stability, and efficient rapamycin loading. In …


Standar Ganti Rugi Materil Dalam Kasus Perbuatan Melawan Hukum Pada Hewan Di Indonesia Berdasarkan Kasus Blackout Pln Pada Putusan Pengadilan Negeri Nomor 09/Pdt.G.S/2019/Pn Jkt Slt, Nathania Debora Siagian, Rosa Agustina Jul 2026

Standar Ganti Rugi Materil Dalam Kasus Perbuatan Melawan Hukum Pada Hewan Di Indonesia Berdasarkan Kasus Blackout Pln Pada Putusan Pengadilan Negeri Nomor 09/Pdt.G.S/2019/Pn Jkt Slt, Nathania Debora Siagian, Rosa Agustina

Lex Patrimonium

This study examines the standard of material compensation for pet deaths due to unlawful acts in Indonesian law, using a case study of District Court Decision No. 09/PDT.G.S/2019/PN JKT Sel, which rejected a claim for the death of four koi fish due to a power outage by PLN. Through doctrinal legal research with case and comparative law approaches, this study finds that Indonesian law still categorizes animals as movable objects, limiting compensation to provable economic loss, without considering emotional value. The court ruled that the power outage was not an unlawful act due to lack of fault, thus limiting PLN’s …


Advances In Gene Editing Strategies For Viral Disease Resistance In Pigs: Knock-Out, Knock-In, And Overexpression Approaches, Zhao Namula, Takeshige Otoi, Aya Nakai, Megumi Nagahara, Maki Hirata, Fuminori Tanihara Jul 2026

Advances In Gene Editing Strategies For Viral Disease Resistance In Pigs: Knock-Out, Knock-In, And Overexpression Approaches, Zhao Namula, Takeshige Otoi, Aya Nakai, Megumi Nagahara, Maki Hirata, Fuminori Tanihara

The Thai Journal of Veterinary Medicine

Highly contagious viral pathogens—such as porcine reproductive and respiratory syndrome, classical swine fever, and African swine fever—continue to pose serious threats to the swine industry and cause major global economic losses. Conventional disease control approaches, such as vaccination and biosecurity, are limited by viral heterogeneity and immune escape mechanisms. Gene editing technologies, most notably the CRISPR/Cas9 system, offer an innovative means of introducing innate viral disease resistance or resilience in pigs. The continuous improvement of these tools can provide a sustainable strategy to enhance animal welfare and global food security and reduce reliance on traditional control measures. This review provides …


Foreword, Adam Fortier-Brown Jul 2026

Foreword, Adam Fortier-Brown

Maine Law Review

Access to legal services in America has emerged as one of the most pressing structural challenges facing the legal community. As attorneys increasingly concentrate in metropolitan areas, large areas are left with few practicing attorneys and challenging prospects of attracting many more. The consequences of this challenge reach across nearly every aspect of life in these communities—from housing and family stability, to starting or winding down businesses, and critically, to the constitutional guarantees that attach when someone is charged with a crime. Yet, these challenges have also generated a period of genuine creativity and collaboration between communities and different institutions. …


Rurality And Redistricting: California's Proposition 50, Rural Identity, And Democratic Legitimacy, Lisa R. Pruitt Jul 2026

Rurality And Redistricting: California's Proposition 50, Rural Identity, And Democratic Legitimacy, Lisa R. Pruitt

Maine Law Review

When California voters embraced mid-decade congressional redistricting in 2025, the greatest media attention landed on the state’s First Congressional District, CA-01. It is residents of that district who are likely to feel the consequences of the new maps most profoundly. In the form established by the California Citizens Redistricting Commission in 2021, CA-01 occupied more than 26,000 square miles in the state’s northeastern corner. The district included a number of inland counties stretching from Modoc, tucked into the corner formed by the Oregon and Nevada state lines, to Colusa, in the Great Central Valley. The cluster of ten counties—hereinafter “old …


"Tac-Ing" On Coherence: Achieving Sustainable Baltic Sea Fisheries Management By Hooking Precautionary Science And Greater Transparency In Eu Total Catch Negotiations, Patrick Seroogy Jul 2026

"Tac-Ing" On Coherence: Achieving Sustainable Baltic Sea Fisheries Management By Hooking Precautionary Science And Greater Transparency In Eu Total Catch Negotiations, Patrick Seroogy

Ocean and Coastal Law Journal

This article argues that what makes the difference in success between these two regimes is how strictly the scientific advice underlying catch limits the advice is adhered to, and the influences allowed unto decisionmakers in the catch limit negotiation process. Whereas the United States uses the scientific advice about the MSY as a strict upper limit in determining annual catch limits, the EU does not. This allows stakeholders in the EU’s CFP governance, in particular fishing industry actors, to influence regulators to raise TACs above adequately precautionary levels in the name of “balancing” sustainable fishing with short-term economic interests. The …


Alaska's Hidden Gems: Advocating For The Protection Of Deep-Sea Corals, Both In The Courtroom And Beyond, Lauren Beizer Jul 2026

Alaska's Hidden Gems: Advocating For The Protection Of Deep-Sea Corals, Both In The Courtroom And Beyond, Lauren Beizer

Ocean and Coastal Law Journal

Coral reefs are ecologically, financially, and aesthetically one of the world’s greatest resources. Off the coast of Alaska, many unique species of deep-sea cold-water corals exist and provide various public health benefits, contribute vital ecosystem functions to their surrounding environment, and serve as economic tourist attractions. Alaska’s corals reefs are exceedingly valuable to the earth due to their overall ecological value. However, these unique coral species significantly lack state and federal protections–which have recently been under consideration in several lawsuits at the federal level. American Oceans Campaign v. Daley and Oceana, Inc. v. National Marine Fisheries Service et al., are …


Editor's Page, Art Mcphee Jul 2026

Editor's Page, Art Mcphee

Witness

No abstract provided.


Evaluation Of Diclazuril And Amprolium Against Eimeria Spp. In Vietnamese Broilers: Implications For Intestinal Integrity And Claudin Gene Expression, Nguyen Thi Hoa, Pham Hoang Son Hung, Le Dinh Phung, Le Duc Thao, Nguyen Van Chao, Tran Thi Na, Tran Cao My Linh, Ho Thi Dung Jul 2026

Evaluation Of Diclazuril And Amprolium Against Eimeria Spp. In Vietnamese Broilers: Implications For Intestinal Integrity And Claudin Gene Expression, Nguyen Thi Hoa, Pham Hoang Son Hung, Le Dinh Phung, Le Duc Thao, Nguyen Van Chao, Tran Thi Na, Tran Cao My Linh, Ho Thi Dung

The Thai Journal of Veterinary Medicine

This study aimed to assess the resistance status of Eimeria spp. in Vietnam to diclazuril and amprolium and to evaluate their effects on intestinal recovery following infection. One hundred 12-day-old chicks were randomly allotted to four groups: a non-infected negative control (NC), an infected untreated as positive control (PC), an infected group treated with diclazuril (DI), and an infected group treated with amprolium (AM). At day 14, chicks from all groups except NC were orally challenged with 2 × 10⁴ sporulated Eimeria oocysts (E. tenella, E. maxima, E. acervulina, and E. mitis). On day 7 …


Conservation Education And The Cultivation Of Environmental Responsibility: Case Studies From Sri Lanka, Jody Miller, Pasindu Dilshan Abegunawardhana Jul 2026

Conservation Education And The Cultivation Of Environmental Responsibility: Case Studies From Sri Lanka, Jody Miller, Pasindu Dilshan Abegunawardhana

International Journal on Responsibility

Conservation education encompasses effective pedagogical practices that enhance knowledge of the environment and foster responsible environmental actions. In addition to building an informed citizenry, conservation education is shaped by theoretical stances about the components necessary to cultivate environmental responsibility among participants and their communities. Highlighting three of our own conservation education projects in Sri Lanka as case studies, we draw from research and debates about environmental responsibility to illustrate the incorporation of environmental engagement and responsibility into these efforts, and the difficulties that arise in doing so. Sri Lanka is one of eight global biodiversity hotspots prioritized for conservation intervention. …


Olli Fall 2026 Catalog, Toniann Leavitt Jul 2026

Olli Fall 2026 Catalog, Toniann Leavitt

Osher Lifelong Learning Institute

No abstract provided.


Hemidiaphragmatic Segmental Zoster Paresis, Terrence Sanvictores, Johnson Ukken Jul 2026

Hemidiaphragmatic Segmental Zoster Paresis, Terrence Sanvictores, Johnson Ukken

School of Medicine Faculty Research

The reactivation of latent varicella-zoster virus within infected neurons can lead to common clinical manifestations, including rash, acute neuritis, post-herpetic neuralgia, herpes zoster ophthalmicus, and Ramsay–Hunt syndrome. Segmental zoster paresis is an unusual neurologic complication of shingles that is defined by focal asymmetric motor weakness in the myotome corresponding to skin lesions of the dermatome. This case is a presentation of a patient who developed chronic hypoxia and severe atelectasis attributed to right-sided phrenic nerve paralysis secondary to herpes zoster infection.


Depaul Digest Jul 2026

Depaul Digest

DePaul Magazine

James Bort, assistant professor at the Driehaus College of Business, levels the playing field for underdog entrepreneurs. Arieahn Matamonasa Bennett, associate professor at the School of Continuing and Professional Studies, helps connect to the natural world through equine-assisted therapy. Plus, alumni pitch in during Vincentian Service Day and the latest news from DePaul's 10 colleges and schools, from music education students teaching youth to law students engaging in international human rights work.


Class Notes Jul 2026

Class Notes

DePaul Magazine

From promotions to performances, see the latest accomplishments by DePaul alumni across class years and generations. Plus, read alumni spotlight profiles of Derrick M. Robinson Jr. (SCPS '11), who battles bullying through sneakers donations, and Alessandra Swanson (JD '09), a first-generation alumna who rose to partner at a prominent national law firm.


Extrafloral Nectaries In Woody Plants: Toward An Integrated Framework For Ant-Mediated Plant Defense, Fangming Liu, Qifei Cai, Victor Busov, Zhen Liu Jul 2026

Extrafloral Nectaries In Woody Plants: Toward An Integrated Framework For Ant-Mediated Plant Defense, Fangming Liu, Qifei Cai, Victor Busov, Zhen Liu

Michigan Tech Publications

Extrafloral nectaries (EFNs)—secretory structures that recruit predatory arthropods as indirect defenders against herbivory—have been studied almost exclusively in herbaceous systems, leaving a critical gap in our understanding of plant defense in woody plants. In trees, secondary growth, ontogenetic regulation, and seasonal phenology generate structural and temporal heterogeneity in EFN expression poorly captured by existing frameworks. We synthesize evidence across structural, chemical, and functional dimensions of EFN biology to develop an integrated framework for perennial trees. Our analysis suggests that methodological limitations in EFN detection likely bias the current chemical record of woody EFNs, while incomplete chemical characterization constrains the evaluation …


Effect Of Virtual Reality Intervention Of Postoperative Pain In Pediatric Surgical Patients, Tara L. Kempker Jul 2026

Effect Of Virtual Reality Intervention Of Postoperative Pain In Pediatric Surgical Patients, Tara L. Kempker

Dissertations

Problem: Pediatric surgical procedures are associated with preoperative anxiety. Preoperative anxiety is associated with higher postoperative pain. Multiple studies have found that decreasing preoperative anxiety using Virtual Reality (VR) Intervention also decreases postoperative pain scores and use of rescue analgesics in postoperative care units (PACU). However, there is no standardized protocol for use of VR interventions and in our institution, VR was not utilized at all.

Methods: This quality improvement (QI) initiative utilized a quasi-experimental design and convenience sampling. Quantitative data was collected during visits for scheduled operative visits for pediatric surgical patients ages seven to 18 years …


Extrafloral Nectaries In Woody Plants: Toward An Integrated Framework For Ant-Mediated Plant Defense, Fangming Liu, Qifei Cai, Victor Busov, Zhen Liu Jul 2026

Extrafloral Nectaries In Woody Plants: Toward An Integrated Framework For Ant-Mediated Plant Defense, Fangming Liu, Qifei Cai, Victor Busov, Zhen Liu

Michigan Tech Publications

Extrafloral nectaries (EFNs)-secretory structures that recruit predatory arthropods as indirect defenders against herbivory-have been studied almost exclusively in herbaceous systems, leaving a critical gap in our understanding of plant defense in woody plants. In trees, secondary growth, ontogenetic regulation, and seasonal phenology generate structural and temporal heterogeneity in EFN expression poorly captured by existing frameworks. We synthesize evidence across structural, chemical, and functional dimensions of EFN biology to develop an integrated framework for perennial trees. Our analysis suggests that methodological limitations in EFN detection likely bias the current chemical record of woody EFNs, while incomplete chemical characterization constrains the evaluation …


Full Issue: Summer 2026 Jul 2026

Full Issue: Summer 2026

DePaul Magazine

In DePaul Magazine's summer 2026 issue, learn how DePaul is living its Vincentian mission through innovative community engagement and service learning, exemplified by its Irwin W. Steans Center and Speech Language Pathology and Occupational Therapy graduate programs. Also, meet alumna Kate Steinberg who revisits her youth and DePaul days as a rising social media influencer, get the latest news from DePaul's 10 colleges and schools, and much more.


Beyond 72 Hours: A Retrospective Evaluation Of Factors Associated With Delayed Surgical Stabilization Of Rib Fractures., Alexis A Schweibinz, Clarisse Solis, Anna Michaud, John Dillis, Katherine A Graham, William B Devoe Jul 2026

Beyond 72 Hours: A Retrospective Evaluation Of Factors Associated With Delayed Surgical Stabilization Of Rib Fractures., Alexis A Schweibinz, Clarisse Solis, Anna Michaud, John Dillis, Katherine A Graham, William B Devoe

OhioHealth Research Institute Articles

BACKGROUND: Surgical stabilization of rib fractures (SSRF) is recognized as a key intervention in reducing morbidity among patients with multiple displaced rib fractures or flail chest. Early SSRF, typically within 72 hours of admission, has been associated with improved outcomes. The factors contributing to delayed stabilization, defined as 72 hours or greater following admission, remain unclear.

METHODS: A retrospective cohort study was performed, evaluating 492 trauma patients who underwent SSRF at a level II trauma center. Patient demographics, injury characteristics, and associated injuries were analyzed to identify factors associated with delayed SSRF. Groups were defined as early (≤72 hours) and …


Multiple Event Segmentation Mechanisms In The Human Brain, Tan T Nguyen, Joset A Etzel, Matthew A Bezdek, Jeffrey M Zacks Jul 2026

Multiple Event Segmentation Mechanisms In The Human Brain, Tan T Nguyen, Joset A Etzel, Matthew A Bezdek, Jeffrey M Zacks

2020-Current year OA Pubs

The human brain segments continuous experience into discrete events, with theoretical accounts proposing two distinct mechanisms: creating boundaries at points of high


Constructing A Lower-Bound Estimate Of The Global Number Of Insect Species On A Hyperdiverse Empirical Foundation, Robert Colwell, Laura Melissa Guzman, Dirk Steinke, Anne Chao, Daniel H. Janzen, Winnie Hallwachs, Austin Baker, Jose L Fernández-Triana, Paul D.N. Hebert, Frank Joyce, Robert Puschendorf, Donald L.J. Quicke, Rodolphe Rougerie, M. Alex Smith, Nelson Zamora, Michael J. Sharkey Jul 2026

Constructing A Lower-Bound Estimate Of The Global Number Of Insect Species On A Hyperdiverse Empirical Foundation, Robert Colwell, Laura Melissa Guzman, Dirk Steinke, Anne Chao, Daniel H. Janzen, Winnie Hallwachs, Austin Baker, Jose L Fernández-Triana, Paul D.N. Hebert, Frank Joyce, Robert Puschendorf, Donald L.J. Quicke, Rodolphe Rougerie, M. Alex Smith, Nelson Zamora, Michael J. Sharkey

School of Biological and Marine Sciences

Estimating the number of insect species on Earth is a daunting challenge. The current consensus estimate—about six million species—is likely far too low, as we will show. Our estimate of the global number of insect species rests on a sample of more than 1,600,000 DNA-barcoded insect specimens representing 53,945 species from 15 “core” Malaise traps deployed in dry forest, cloud forest, and rainforest ecosystems of the Área de Conservación Guanacaste (ACG) in Costa Rica. Even this massive sample fails to reveal the full extent of ACG insect species richness. To estimate total ACG insect richness, we adjust the observed count …


Tips For Growing Garden Vegetables In Utah: Soil Fertilization, Gastone Makalaya, Josh Martin, Milena Oliveira Jul 2026

Tips For Growing Garden Vegetables In Utah: Soil Fertilization, Gastone Makalaya, Josh Martin, Milena Oliveira

All Current Publications

A successful vegetable garden requires precise nutrient management to achieve maximum yields. Fertilization must provide adequate nutrients to support plant growth throughout the season. Fertilizer applications should be based on soil test recommendations and crop nutrient requirements. This fact sheet provides Utah gardeners with practical guidance and tips on soil fertilization for vegetable gardening.


Uk Sensorimotor Conference 2026, Ian Howard, Gunnar Schmidtmann, Chris Fogwill, Antonio Capozio, Nick Holmes, Joe Galea, Zoltan Soltesz, Natalie Maffitt, Flàvia Ferrus Marimon, Jonathan Marsden, Jon Green, Bethan Thomas, Raymond Reynolds, Griet Warlop, Callum Jarvis, Gabriela Gonzalez Chan, Stephen Hall, Caitlin Smith, Isabel Farr, Adam Shann Jul 2026

Uk Sensorimotor Conference 2026, Ian Howard, Gunnar Schmidtmann, Chris Fogwill, Antonio Capozio, Nick Holmes, Joe Galea, Zoltan Soltesz, Natalie Maffitt, Flàvia Ferrus Marimon, Jonathan Marsden, Jon Green, Bethan Thomas, Raymond Reynolds, Griet Warlop, Callum Jarvis, Gabriela Gonzalez Chan, Stephen Hall, Caitlin Smith, Isabel Farr, Adam Shann

UK Sensorimotor Conference

The 2026 UK Sensorimotor Conference in Plymouth aims to bring together the UK sensorimotor community in an open and informal environment to share research, exchange ideas, and foster new collaborations.  The meeting will encompass a broad scientific scope, spanning basic and clinical studies across humans and animals, motor control and learning, neuromuscular and vestibular systems, development and ageing, as well as computational, neuroimaging, electrophysiological, and robotic approaches to sensorimotor function.


Tau Pathology In Epilepsy: Emerging Mechanisms And Translational Opportunities, Arjune Sen, Xin You Tai, Aristea Galanopoulou, Maria Thom, Eleonora Aronica, Lucy Vivash, Martin Hardmeier, Action Amos, Stephan Rueegg, Matthias Koepp, Yaroslav Winter, Christoph Helmstaedter, Jeffrey L Noebels, Hilal A Lashuel, Terence J O'Brien Jul 2026

Tau Pathology In Epilepsy: Emerging Mechanisms And Translational Opportunities, Arjune Sen, Xin You Tai, Aristea Galanopoulou, Maria Thom, Eleonora Aronica, Lucy Vivash, Martin Hardmeier, Action Amos, Stephan Rueegg, Matthias Koepp, Yaroslav Winter, Christoph Helmstaedter, Jeffrey L Noebels, Hilal A Lashuel, Terence J O'Brien

Faculty, Staff and Students Publications

The onset of epilepsy in adulthood occurs most commonly after 55 years of age. Given the ageing global population, this disorder represents an increasing burden on healthcare and society. The bidirectional link between epilepsy and dementia is a focus of intense research with underlying tau pathology highlighted as a potential mechanistic link. In this review, we examine the evidence for tau-related neurodegenerative processes in epilepsy beginning with how changes in biochemical and structural properties of the tau protein can lead to abnormal phosphorylation and pathological aggregation. We consider the role of tau in seizure occurrence and cognitive difficulties in experimental …


Dietary Fat Intake And Its Influence On The Association Between Liver Fat And Brain Choline Metabolism In Young Saudi Women, Halima S. Hawesa, Mansour E. Shanawani, Haya A. Alshegri, Mahasin G. Hassan, Amal I. Alorainy, Nouf A. Alroqaiba, Shanoo G. A. Sheikh Jul 2026

Dietary Fat Intake And Its Influence On The Association Between Liver Fat And Brain Choline Metabolism In Young Saudi Women, Halima S. Hawesa, Mansour E. Shanawani, Haya A. Alshegri, Mahasin G. Hassan, Amal I. Alorainy, Nouf A. Alroqaiba, Shanoo G. A. Sheikh

Saudi Medical Journal

Objective: Fat-rich nutrition may influence the neurochemical consequences of hepatic lipid accumulation. This study examined whether percent energy from fat modifies the association between liver fat and the brain (Cho/Cr) ratio in healthy young women. Methods: A total of 109 healthy Saudi women aged 18–25 years underwent brain magnetic resonance spectroscopy (1H-MRS) to quantify Cho/Cr ratios. Liver fat was estimated using MRI-based proton density fat fraction (PDFF), and lipid intake was assessed using a validated food frequency questionnaire. Multivariable regression models tested the interaction between liver fat and fat-derived energy intake, followed by simple slopes analysis, regression …