Digital Commons Network^™

Study On Structural Characteristics And Immunomodulatory Activity Of Flammulina Velutipes Crude Polysaccharide, Wang Xinnuo, Peng Chujun, Jin Yumeng, Zhang Molan, You Lijun

Food and Machinery

[Objective] To prepare Flammulina velutipes crude polysaccharide (FVP) and evaluate its structural characteristics and immunomodulatory activity. [Methods] FVP was prepared from Flammulina velutipes using hot-water extraction and ethanol precipitation, and its structural characteristics were characterized by combining Fourier transform infrared spectroscopy (FTIR) and high-performance size-exclusion chromatography–multi-angle laser light scattering–refractive index detection (HPSEC–MALLS–RI). The immunomodulatory activity of FVP was evaluated using RAW 264.7 macrophages and a cyclophosphamide-induced immunosuppressed mouse model. [Results] The total sugar content of FVP is (51.39 ± 1.36) g/100 g. Structural characterization results show that FVP has characteristic features of a β-type pyranose ring and exhibits a multi-component …

Comparative Analysis Of Beef Quality From Bashan Region, Wan Xiaohui, Yao Pingbo, Zhang Duoduo, Ma Xiaowen, Tang Youxue, Liu Yongfeng

Food and Machinery

[Objective] To clarify the unique quality of beef from the Bashan region. [Methods] Xizhen cattle beef from the eastern, southern, south-central, central, and northern regions of Zhenba County, Shaanxi Province, is taken as the material to investigate the differences in nutritional quality (moisture, protein, fat, and minerals) and eating quality (color, texture, and flavor). [Results] Zhenba beef has unique qualities, such as high protein and total mineral content, compared with the nutrient composition of beef in the food nutrient composition database published by the National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. For nutritional quality, …

Effect Of Modified Hemoglobin As A Substitute For Sodium Nitrite On The Quality Of Ham Sausage, Qu Shulei, Ma Chao, Yao Xianqi, Du Dongxu, Wang Wei, Liu Yunguo

Food and Machinery

[Objective] To improve the utilization rate of porcine blood and the safety of ham sausage. [Methods] Under specific conditions, hemoglobin in porcine blood is modified to produce glycosylated nitrosohemoglobin (GN-Hb). Different amounts of GN-Hb are added to replace sodium nitrite in heat-treated ham sausages. The quality characteristics of the sausages are evaluated through texture analysis, nutritional testing, color difference assessment, color acceptability, elasticity, chewiness, and overall acceptability. [Results] When the sodium nitrite dosage is 100 mg/kg and the GN-Hb dosage is 2.5 g/kg, high-temperature sterilized ham sausage containing the new pigment shows significant improvement in color and cohesion compared with …

A Review Of Metabolic Mechanisms Of N-Nitroso Compounds And Measures For Their Reduction And Control, Wang Zhulin

Food and Machinery

N-nitroso compounds, as one of the major food contaminants, are widely present in food and pose hazards such as carcinogenicity, teratogenicity, and mutagenicity, thus being a key focus in food safety monitoring. Although significant progress has been made in the research on N-nitroso compounds, studies on their metabolic mechanisms and reduction and control measures are still disconnected to a certain extent. Through a review of the classification, detection methods, and toxic effects of N-nitroso compounds, this article analyzes the intrinsic connection between their metabolic pathways in the body and strategies for external reduction and control, aiming to provide theoretical references …

Trustworthiness As Inferential Accountability In Qualitative Research, Aamir Rashid, Rizwana Rasheed

Publications and Research

Trustworthiness is a cornerstone of qualitative research rigor, yet it is frequently operationalized as a procedural checklist rather than as a coherent logic for justifying qualitative knowledge claims. As a result, qualitative studies often demonstrate methodological diligence without fully explicating how empirical materials warrant the interpretations advanced or how the scope of those interpretations should be bounded. The purpose of this paper is to reconceptualize trustworthiness as inferential accountability, understood as a governing evaluative principle for qualitative inquiry that provides a coherent and contemporary framework for the justification, evaluation, and delimitation of qualitative claims. The paper adopts a conceptual and …

Biotic Therapies For Irritable Bowel Syndrome: Current Interventions, Gina Wodarczyk, Maria Winte, Diana Mastellone, Termen Singh, Joshua Desipio, Sangita Phadtare

Division of Gastroenterology and Hepatology Faculty Papers

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by recurrent abdominal pain and changes in bowel habits without measurable disease processes. Recent research emphasizes the gut-brain-microbiome (GBM) axis and explores how microbiota influence gastrointestinal and central nervous system functions. Here, we first discuss a brief overview of various treatment approaches for IBS, focusing on interventions such as probiotics, prebiotics, or synbiotics that target the GBM axis in adults with IBS. Relevant trials discussed the use of probiotics, prebiotics, or synbiotics.

Sources And Potential Risks Of Micro- And Nanoplastics In Foods, Zhao Xinlong, Li Wei, Zhang Mengling, Xing Liwen, Tian Huafeng

Food and Machinery

Plastics are widely used in food packaging, storage, processing, and other food-related applications, playing a vital role in extending food shelf life, reducing material loss, and promoting food circulation. However, these plastic products that come into direct or indirect contact with foods can release micro- and nanoplastics through various physical and chemical processes. These micro- and nanoplastics can accumulate in the human body through bioaccumulation and other pathways and have become one of the emerging contaminants threatening food safety and human health. This review provides a comprehensive summary of the research progress on the generation pathways, release mechanisms, potential health …

Screening Of Weizmannia Coagulans With High Stress Tolerance, Xiao Xue, Yu Wendi, Hu Yuanliang, Zhang Xicai, Yu Xiang

Food and Machinery

[Objective] To isolate and screen novel Weizmannia coagulans strains with high stress tolerance. [Methods] Using commercially fermented pickle brine as the sample, W. coagulans strains were isolated, purified, and identified by selective culture medium methods, morphological observation, physiological and biochemical characterization, and 16S rDNA sequencing. Taking survival rate as the evaluation index, the stress tolerance of the isolated strains and three laboratory-preserved W. coagulans strains was determined under high-temperature (80–100 ℃), acidic (pH 2.0–3.0), and bile salt (0.1%–0.5%) conditions. Principal component analysis (PCA) was applied to comprehensively assess the stress tolerance of the tested strains. [Results] Two W. coagulans strains, …

Effects Of Pretreatment Methods On Volatile Compounds And Active Ingredients In Flaxseed Oil, Zhu Lijun, Chen Fengzhen, Zhang Chengshuang, Zhao Baoyi, Meng Lingjun

Food and Machinery

[Objective] This paper aims to investigate the effects of microwave and roasting pretreatment methods on volatile compounds and active ingredients in flaxseed oil. [Methods] Flaxseeds were pretreated by microwave (720 W, 2–8 min) and roasting (140–200 ℃, 30 min), and then flaxseed oil was prepared by cold pressing. Using untreated cold-pressed flaxseed oil as a control, the differences in volatile compounds were analyzed by headspace gas chromatography–ion mobility spectrometry (HS-GC-IMS) and an electronic nose. Additionally, the contents of tocopherols, phytosterols, and total phenolics were determined. [Results] A total of 72 volatile compounds are identified by HS-GC-IMS analysis, including aldehydes (20 …

Advances In The Application Of Electroencephalography In Food Sensory Science, Li Wenbin, Hou Xiaoyi, Deng Na, Leng Tuo, Fu Haohua, Wang Jianhui

Food and Machinery

Traditional sensory evaluation of food is affected by subjectivity and other factors, resulting in significant limitations. Electroencephalography (EEG), owing to its advantages of high temporal resolution, non-invasiveness, and real-time dynamic monitoring, offers an objective neurophysiological perspective and analytical approach to address this issue, effectively advancing food science research from subjective descriptions to objective neural decoding. This paper systematically reviews the applications of EEG in food flavor recognition and prediction, objective evaluation of food quality, and analysis of food nutrition and consumer behavior. In light of the current state of technological development, it is proposed that multimodal technology integration and machine …

Hot And Bothered: Introduced Generalist Marine Snail Outperforms Native Specialist Under Gradual And Extreme Warming, Alysha B. Putnam, Adeline Dwyer, Danielle T. Weiss, Bethany A. Bradley, Michelle D. Staudinger, Paulette Peckol

Biological Sciences: Faculty Publications

Climate change is reshaping coastal ecosystems through gradual warming and increasingly frequent extreme heat events, potentially affecting native and introduced species differently. We experimentally compared the native marine snail Littorina obtusata, a habitat and dietary specialist, to the introduced generalist Littorina littorea under sustained warming and short-term extreme heat. We measured survival and performance metrics, including grazing, growth, and attachment strength, under short- and long-term thermal stress in air and water. L. littorea consistently outperformed L. obtusata, maintaining or increasing function under warming and exhibiting greater survival during simulated heatwaves. Conversely, L. obtusata showed performance declines and higher …

Presentation On Scientific Activities Related To Environmental Law, Mahjoub El Haiba El Haiba

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

Environmental problems have a global character due to the interdependence of biosphere components, yet they also have significant local dimensions. Climate change and the greenhouse effect, which have intensified in recent decades, pose serious threats to biological balance and endanger human, plant, and animal life. While these issues demand global solutions, local responsibility remains crucial, as the causes and impacts vary across regions. This presentation highlights the scientific activities of the Moroccan Association for Environmental Law, which organizes events—such as roundtables on ozone layer protection—aimed at bridging scientific knowledge and legal frameworks to address both global and local environmental challenges …

Slc Transporter-Mediated Functional Imaging In Cancer Diagnosis, Lumeng Zhang, Jun He

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Functional imaging has become an important approach for evaluating tumor physiology in vivo beyond morphologic assessment. Radiotracers used for cancer imaging are designed to mimic endogenous substrates or substrate analogues, and their accumulation can depend on membrane transport, intracellular metabolism, and clearance from normal tissues. Specifically, SLC transporters contribute to tracer uptake and signal formation, linking transporter activity with measurable imaging signals in cancer. While [18F]FDG PET/CT remains the most widely used example of transporter-associated metabolic imaging, SLC transporter-mediated imaging strategies have been developed to assess amino acid transport, sodium-dependent glucose uptake, redox metabolism, lactate exchange, nucleoside metabolism, choline metabolism, …

Medieval, Magical, Or Melodramatic? Depictions Of Elrond Half-Elven In Film And Television Adaptations, Kristine Larsen

Journal of Tolkien Research

Elrond Half-elven acts as an important bridge between the First, Second, and Third Ages of Middle-earth, as well as between multiple species (Maia, Elf, and Human). He thus presents writers and directors of film and television adaptations with both challenges and opportunities to investigate intersections between the medieval and the modern, myth and magic, fidelity to the original and creative exploration. Adaptations often condense and simplify plot points and scenes for the sake of time or story/telling. In the case of Elrond, this means that we should expect changes in his main scenes in The Hobbit (Elvish sword identification and …

Depression And Anxiety In Pulmonary Hypertension Associated With Congenital Heart Disease: Pathophysiology And Clinical Implications Of The Heart–Brain Axis, Nicodemus N. Triatmojo, Valerinna Y.S. Putri

Journal of the Saudi Heart Association

Pulmonary hypertension associated with congenital heart disease or PH-CHD is an increasingly prevalent disorder in modern cardiology. It is characterized by progressive pulmonary vascular remodeling, chronic right ventricular (RV) pressure overload, and abnormal cardiopulmonary hemodynamic. Due to advances in congenital cardiology and treatments for pulmonary hypertension, survival rates have increased. As a result, the focus has switched to long-term functional status and quality of life. Depression and anxiety are currently recognized as prevalent and clinically significant manifestations in PH-CHD; nonetheless, they remain underdiagnosed and undertreated within cardiovascular care frameworks.

More study shows the disease's severity or symptom count cannot explain …

An Ecophysiological Approach To Improving Health Outcomes Of Ornamental Shrimp During Aquarium Trade And Transportation, Sancha Conway Holroyd, John Spicer, Robert P. Ellis, Lucy Turner

School of Biological and Marine Sciences

Ecophysiology examines the interactions between an organism’s physiology and its environment. It seeks to understand how an organism functions and adapts under changing conditions. This has direct applications to live-trade aquaculture sectors, including the ornamental aquarium trade, where traded animals experience a variety of changing, and often stressful, environmental conditions that can threaten their health and survival. This review proposes a role for ecophysiology in managing organismal health, using Hatch (1962) theoretical framework of disease and dysfunction as a foundation for defining and distinguishing health. We focus on tropical (marine and freshwater) ornamental shrimp as an exemplar group to highlight …

Feasibility Study Of An Artificial Intelligence Chatbot-Powered Cognitive-Behavioral Lifestyle Modification Program, Evans Forman, Charlotte Hagerman, Asher Hong, Zhuoran Huang, Hannah Mccausland, Jasmine Sun, Lauren Taylor, Meghan Butryn, Preetha Chatterjee, Ramtin Ehsani, Nawal Syed

Department of Family & Community Medicine Faculty Papers

Background: Approximately 2 billion adults seek lifestyle modification to improve their health and well-being. However, because of cost and access barriers, only a tiny fraction receive gold-standard lifestyle modification programs led by trained coaches. Digital programs without human coaches are more disseminable but have limited efficacy. Recent advances in large language model (LLM) AI chatbots have the potential to revolutionize digital programs by emulating human coaches, offering a safe, low-cost, and scalable lifestyle modification intervention. Yet, no studies have developed and tested such a program. Purpose: This study aims to evaluate the feasibility, safety, and user engagement of a new …

A Phase Ii Trial Of Defactinib Combined With Avutometinib In Patients With Metastatic Uveal Melanoma, Rino S. Seedor, Mizue Terai, Sergei A. Koshkin, Andrew E. Aplin, Marlana Orloff, Erin Sharpe-Mills, Madeleine Naccarato, Aurora Mills, Alfredo A. Molinolo, J. Silvio Gutkind, Takami Sato

Kimmel Cancer Center Faculty Papers

Background: Treatment options are limited, and outcomes remain poor for patients with metastatic uveal melanoma (MUM). We conducted an investigator-initiated, prospective, single-arm, single-institution, phase II study evaluating the combination of an FAK inhibitor (defactinib) with a RAF/MEK inhibitor (avutometinib) for the treatment of MUM. Methods: From February 2021 through January 2023, 12 patients with MUM were treated with the combination of defactinib and avutometinib. Defactinib was given 200 mg twice daily, and avutometinib was given 3.2 mg twice a week. Both drugs were given for 3 weeks on and 1 week off (28-day cycle). Disease control rate was the primary …

Impact Of Social Media-Driven Feeding Practices On The Gut Microbiome Of Captive Asian Elephants (Elephas Maximus) In Surin, Thailand, Pongpreecha Malaluang, Nuttapon Bangkaew, Jaruwan Chaiyakhot, Patinya Patikae, Nattaya Watwiengkam, Phimphanit Choklikitumnuey, Thanaphat Phupanna, Sudachanok Phowiset, Prim Chuesaard, Tarid Purisotayo

The Thai Journal of Veterinary Medicine

This study investigated the effects of social media-driven live-streaming dietary supplementation on the gastrointestinal microbial community of captive Asian elephants (Elephas maximus) at the Elephant Kingdom, Surin Province, Thailand. A hierarchical two-tier observational design was used: Tier 1 compared a minimal-supplementation control group (Group H, n = 6) with a frequent heterogeneous-supplementation group (Group L, n = 18); Tier 2 compared, within Group L, low-frequency (Group A, ≤ 3 sessions per week, n = 7) and high-frequency (Group B, > 3 sessions per week, n = 11) live-streaming sub-groups. Faecal microbial profiles were obtained by 16S rRNA gene (V3–V4) …

Design, Fabrication, And Performance Evaluation Of A Recycling Machine For Converting Biodegradable Waste Into Compost, Mohamed T. Eraky, M.M Radwan, Abdelkhalik Eladl

Mansoura Engineering Journal

This study evaluates the technical feasibility of composting shredded printed paper blended with organic waste using a manually operated aerobic composting system. The investigation focused on process performance under controlled initial conditions, particularly an optimized carbon-to-nitrogen (C:N) ratio of 30:1. Three composting piles were constructed with systematic variations in moisture content, aeration frequency, and additive composition (poultry manure, yeast, crushed eggshells, and cardboard) to assess their influence on thermal behavior and decomposition efficiency. Process performance was monitored through continuous temperature profiling and periodic observation of physical parameters, including color development and material degradation rate. Among the experimental setups, Pile 3 …

Electrospun Nanofiber Dressings: Advances In Fabrication, Polymers, And Clinical Applications For Skin Healing, Ahmed Yaseen, Maher Abdulrazzaq Luqman Al-Hakeem, Yasir Qasim Almajidi, Yaseen Taha Aljuburi

Maaen Journal for Medical Sciences

The increasing global need for more effective wound care arises because conventional dressings have limited antibacterial efficacy and other shortcomings. The protection that is provided by the materials used for dressing and the drug delivery to the wounds is crucial in the management of wounds. Today, extracellular matrix ECM structure and function-mimicking electrospun nanofiber membranes are deemed one prospective next-generation alternative for dressings in wounds. This review examines electrospun nanofiber dressings with an overview of fabrication principles, polymer selection, and challenges for clinical translation in an attempt to establish the current status and prospects of these dressings in the management …

The Host's Immune Responses Against Viruses: How We Know Our Own Bodies And How Our Bodies Defend Themselves From Viruses, Eman A. Muhsin, Neyaf Majid Alageedi, Shahrazad Ahmed Khalaf

Maaen Journal for Medical Sciences

Background: Viral infections pose a significant threat to health worldwide, requiring a coordinated and effective immune response to limit and eventually eliminate viral infection. The purpose of this review is to examine the different ways by which the immune system responds, both by innate and adaptive pathways, against viral infections, along with the mechanisms by which viruses evade host immune responses.

Method: A systematic literature review was performed with an organized search through the following databases; PubMed, Scopus, Web of Science and ScienceDirect. The search was for studies published between 2015-2025. The final number of included articles was 45 as …

Antibacterial Efficacy Of Resin-Based Dental Composites Modified With Antibacterial Agents Against S. Mutans: A Systematic Review, Ahmad Setiawan Jarigau, Erwin Gunawan, Muhammad Akira Takashi Dharma, Fanny Dinda Nur Aulia, Lenni Indriani Hatta, Nurhayati Natsir

International Arab Journal of Dentistry

Introduction: Dental caries caused by Streptococcus mutans is a leading cause of dental restoration failure. Enhancing composite resins with antibacterial agents aims to inhibit bacterial growth and prolong restoration life.

Objectives: This review evaluates the anti-bacterial agents efficacy of these modified composites against S. mutans and explores their mechanisms and potential clinical benefits.

Methods: A comprehensive literature search was conducted across multiple databases following PRISMA guidelines, focusing on in vitro studies published between 2015 and 2025. Studies evaluating composites with antibacterial additives against S. mutans using standard microbiological assays were included. The quality of eligible studies was assessed using the …

Evaluation Of Optimal Force For Intrusion Of A Periodontally Compromised Maxillary Anterior Dentition Treated With Fixed Orthodontics – A Finite Element Analysis, Tanzim Ahmed, Amrita Puri, Aatira Nair, Anshul Singla, Mathew Koshy Vaidyan, Shruti Sharma, Chhavi Singh

International Arab Journal of Dentistry

Introduction: Adult orthodontic treatment is increasingly sought due to aesthetic and functional concerns, often involving periodontally compromised patients with altered biomechanics. Reduced bone support shifts the center of resistance and necessitates lower, carefully controlled forces, while finite element modeling has become a key tool to analyze tissue response under such conditions.

Objectives: The study aimed to determine the optimal intrusive force for periodontally compromised maxillary anterior teeth using Finite Element Analysis (FEA).

Methods: A 3D finite element model of the maxillary anterior dentition was created and divided into healthy and compromised halves, the latter with one-third alveolar bone loss. A …

Impact Of Antihypertensive Medications On Implant Success: A Retrospective Cohort Study On Monomedicated Patients, Antony Chidiac, Stephanie Mrad, Charbel Kachouh, Richard M. Sadaka, Joseph Bassil

International Arab Journal of Dentistry

Objective: The aim of this study main is to analyze the influence of antihypertensive treatments on the failure and survival rates of dental implants.

Methods: Medical records of 586 patients who received a total of 1,814 dental implants between 2012 and 2022 met the inclusion criteria and were retrospectively reviewed. Patients were divided into two groups: a control group comprising 512 systemically healthy patients with 1581 implants, and a group of 74 patients taking only antihypertensive medications who received a total of 233 implants. Implant failure was assessed according to criteria defined by the International Congress of Oral Implantologists.

Results: …

Hypo-Responsiveness Of The Dental Pulp In Patients With Type 2 Diabetes And Hypertension: A Cross-Sectional Study, Kavitha M, Mallolu Anthony Sanjana Vijay, Niveditha B, Fathima A.I, Pavithra D, Vigneshwaran J

International Arab Journal of Dentistry

Introduction: Diabetes mellitus and hypertension, two of the most prevalent metabolic disorders worldwide, exert profound and progressive effects on multiple physiological systems. While their systemic complications are well documented, their subtle yet clinically significant impact on oral structures, particularly the dental pulp, remains underexplored.

Objectives: This study aims to assess the functional responsiveness of dental pulp nerves in individuals with type 2 diabetes mellitus and systemic hypertension, and to compare the findings with responses from healthy individuals, using an Electric pulp tester (EPT) as a diagnostic tool.

Methods: A total of 600 teeth from 75 adult patients (25 diabetic, 25 …

The Efficacy Of Mini-Screw Rapid Palatal Expansion (Marpe) In Late Adolescents And Young Adults: A Systematic Review, Afaf El Merouani Drissi, Hajar Ben Mohimd, Hicham Benyahia, Fatima Zaoui

International Arab Journal of Dentistry

Introduction: Mini-screw assisted rapid maxillary expansion (MARPE) emerged as a less invasive alternative treatment for transverse maxillary expansion, and designed to overcome the limitations of conventional rapid maxillary expansion for patients from post-pubertal growth spurt period onwards, often presenting with an interdigitated suture. The aim of this systematic review is to evaluate the efficacy of this treatment on skeletal, dento-alveolar and periodontal levels based on CBCT studies, by comparing it to the conventional rapid maxillary expansion (RPE).

Methods: a literature search of five databases (PubMed, Scopus, Web of Science, ScienceDirect and the Cochrane library) was conducted from 2010 until July …

Employing Artificial Intelligence For Non-Invasive Diagnosis Of Craniofacial Deformities: A Systematic Review Of Non-Ionizing Radiation Methods, Nurul Mutmainnah, Harun Achmad, Lusy Damayanti

International Arab Journal of Dentistry

Introduction: Craniofacial deformities, like craniosynostosis and plagiocephaly, require early diagnosis, but traditional methods like CT scans use harmful ionizing radiation. Artificial Intelligence (AI) offers a non-invasive, radiation-free alternative, using 2D and 3D imaging for accurate diagnosis, improving safety and accessibility, especially in remote areas.

Objective: This review evaluates the use of AI in diagnosing craniofacial deformities without ionizing radiation, focusing on its strengths, limitations, and challenges in clinical implementation.

Methods: The literature was searched across five databases—PubMed, Google Scholar, ScienceDirect, Wiley, and Cochrane—over the last decade, following PRISMA guidelines. Inclusion criteria were AI-based, non-invasive imaging techniques for craniofacial deformities. The …

Category-Adaptive Recall Depth (Card) For Heat-Tiered Memory Systems, With Experimental Validation On Longmemeval-500, Arko Sanyal

Defensive Publications Series

We present Category-Adaptive Recall Depth (CARD), a retrieval mechanism for heat-tiered memory systems that conditions top-K depth and ranking strategy on a query category signal. Prior memory retrieval systems apply a fixed top-K regardless of query semantics; CARD instead assigns each query to one of four categories—information extraction (IE), knowledge update (KU), multi-session reasoning (MSR), temporal reasoning (TR)—and selects a per-category (K, ranking_strategy) pair optimized for that category's retrieval demands. KU queries additionally filter to the highest-version record per entity, enabling 100.0% accuracy on knowledge update tasks. We evaluate CARD integrated with LOCI (Layered Output and Context Intelligence), a heat-tiered …

On The Horizon, Matthew Recker

Calliope

No abstract provided.