Digital Commons Network^™

Markets We Thought We Knew, Nicole J. Olynk Widmar, Michael L. Smith, Erin Robinson

Purdue University Press Books

Markets We Thought We Knew explores the evolving nature of markets and how they shape—and are shaped by—consumer behavior. From essential life necessities such as water to everyday commodities and products including locally sourced foods, this book covers a variety of topics and invites readers to examine a diverse range of markets through a reflective lens. By revisiting past market dynamics and real-world examples, readers are encouraged to rethink how preferences are formed, how opinions shift over time, and how value is assigned—sometimes in unexpected ways. What insights might you gather from a deeper understanding of local and global markets, …

Soil And Water Education For Grades 3-12, Natalie J. Carroll, Christian Y. Oseto, Timothy J. Gibb

Purdue University Press Books

Soil and Water Education for Grades 3–12 was written for youth who enjoy learning about science and two critical natural resources: soil and water. Level 1 introduces basic terms and concepts, and is intended for youth in grades 3–5. Activities focus on understanding important soil and water processes. Designed for students in grades 6–8, Level 2 offers readers more concrete examples of advanced soil and water concepts. The exercises in Level 3, which is geared toward grades 9–12, are divided into sections based on how readers might use the information they have learned, placing them in the shoes of homeowners, …

Laozi’S "Daodejing": A New Translation With Environmentalist Commentary, Steve Hallett

Purdue University Press Books

Laozi’s “Daodejing”: A New Translation With Environmentalist Commentary offers a new translation and fresh interpretation of the eighty-one-verse Daodejing, one of the central texts of Eastern philosophy. Likely written during the late Zhou Dynasty between 600–400 BCE, this foundational work is generally attributed to an individual named Laozi, although it is unlikely that any such person actually existed. Here, author Steve Hallett employs contemporary poetic form when translating the document’s approximately 5,000 Chinese characters and provides short analytical essays that illuminate the verses with a specific focus on the teachings they offer about social and environmental sustainability. His examination of …

Early Pottery At 11,200 Years Ago In The Southern Mongolian Plateau, Xiangge Zhang, Xujiao Zhang, Haoyue Zhang, Martin Stokes, Zhihu Sun, Jingwen Xu, Yifin Wang, Junlei Li, Haoshu Rao, Long Deng, Jingmin Guo, Xin Jia

School of Geography, Earth and Environmental Sciences

he invention of pottery played a crucial role in human history, promoting human settlement and the transition to an agricultural society [1,2]. Pottery first emerged in East Asia during the Late Pleistocene/Paleolithic across a diverse range of environmental settings, becoming more widespread with the climatic warming of the Holocene/Neolithic [3]. The relatively cold Mongolian Plateau was a key region for early human adaptation. Here, numerous archaeological sites have been discovered since the Upper Palaeolithic, including the earliest pottery sites dating back to approximately 12,000 years ago in the northern areas [4,5]. However, no pottery sites predating 10,000 cal a BP …

Spinach (Spinacia Oleracea L) Flavonoids Are Hydrolyzed During Digestion And Their Bioaccessibility Is Under Stronger Genetic Control Than Raw Material Content, Michael P Dzakovich, Alvin L Tak, Elaine A Le, Rachel P Dang, Benjamin W Redan, Geoffrey A Dubrow

Children’s Nutrition Research Center Staff Publications

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Facts And Hopes Of Chimeric Antigen Receptor-Redirected Nk T Cells, Amy N Courtney, Xin Zhou, Gengwen Tian, Ying Wang, Leonid S Metelitsa, Gianpietro Dotti

Faculty, Staff and Students Publications

Chimeric antigen receptor (CAR)-engineered invariant NK T cells (CAR-NKT) are a novel cell platform for cancer immunotherapy. Unlike conventional T cells, NKTs are characterized by innate antitumor properties, minimal alloreactivity, and a unique ability to modulate the tumor microenvironment. This article provides a comprehensive overview of preclinical and early clinical studies evaluating CAR-NKTs in both autologous and allogeneic clinical settings. We discuss the contributions of CAR signaling domains, cytokine coexpression, and other functional measures that correlate with CAR-NKT persistence, function, and metabolic fitness. We also discuss the critical role of immunocompetent animal models in elucidating the interactions of CAR-NKTs with …

Mitochondrial Complex Ii Orchestrates Divergent Effects In Cd4+ And Cd8+ T Cells, Keisuke Seike, Shih-Chun A Chu, Yuichi Sumii, Takashi Ikeda, Meng-Chih Wu, Laure Maneix, Dongchang Zhao, Yaping Sun, Marcin Cieslik, Pavan Reddy

Faculty, Staff and Students Publications

Mitochondrial metabolism orchestrates T cell functions, yet the role of specific mitochondrial components in distinct T cell subsets remains poorly understood. Here, we explored the role of mitochondrial complex II (MC II), the only complex from the electron transport chain (ETC) that plays a role in both ETC and metabolism, in regulating T cell functions. Surprisingly, MC II exerts divergent effects on CD4+ and CD8+ T cell activation and function. Using T cell-specific MC II subunit, succinate dehydrogenase A-deficient (SDHA-deficient) mice, we integrated single-cell RNA-seq and metabolic profiling, with in vitro and in vivo T cell functional assays to illuminate …

A Long Non-Coding Rna Leat1 Mediates The Hormone Responsiveness Of Efnb2 During Male Urogenital Development, Deidre Mattiske, Pascal Bernard, Paul E Gradie, Richard R Behringer, Paul A Overbeek, Rachel J O'Neill, Tiffany Phillips, Melanie Stewart, Neil Youngson, Gerard Tarulli, Andrew J Pask

Faculty, Staff and Students Publications

The novel long non-coding RNA (lncRNA) Leat1 is extraordinarily conserved in both its location (syntenic with EfnB2, an essential gene in anogenital patterning) and sequence. Here we show that Leat1 is upregulated following the production of testosterone from the developing testis in mice and interacts with EfnB2, positively regulating its expression. Leat1 expression is suppressed by estrogen, which in turn suppresses the expression of EfnB2. Moreover, the loss of Leat1 leads to reduced EfnB2, resulting in a severe hypospadias phenotype. The human LEAT1 gene is also co-expressed with EFNB2 in the developing human penis, suggesting a conserved function for this …

Role Of Recreational Fisher Information In Fisheries Management, Rebecca M. Krogman, Stephen M. Taylor, Aaron J. Adams, Ross E. Boucek, Steven M. Lombardo, Chelsey A. Crandall, Susan F. Steffen, Alejandro Acosta, Eduardo Bone Moron, Sepp Haukebo, Kieran Hyder, Zachary M. Radford, Warren M. Potts

Books & book chapters

Fisheries managers work with the three components of fisheries—biota, environment, and people - to achieve recreational, stewardship, and socioeconomic goals. Although manipulation of biota and the aquatic environment remains popular (e.g. harvest regulation, protecting or enhancing habitats, and guarding water quality), the human dimension of fisheries must also be considered throughout the fisheries management process. Managers can and should engage fishers in a myriad of ways, from identification of problems to guidance on alternatives, and from measurement of change to evaluation of success. In this chapter, we review common fisheries management goals and objectives; detail information needs stemming from those …

Catherine, Reagan Christie

Theses

A golden lamb sleeps peacefully in a quiet meadow, showcased in an intricate golden frame. She wakes up and slowly begins to stand, her knobby knees trembling all the way up. She steadies herself, turning toward the viewer, blinking. Catherine looks at her reflection in a grimy sink full of water. The sink drips, reflection dissipating. She looks up into the mirror above the sink in an endless bathroom, tucks a loose curl of hair back into her habit, and exits the bathroom. Catherine makes her way down a long spiral staircase, humming a hymn to herself. In the kitchen, …

Liminal Arts And Business: An Autoethnographic Analysis Of A New Arts Venture In An Entrepreneurial Startup Accelerator Program, Jill Schinberg, Rebecca A. Ferrell, Dan Sandfelder

Journal of Arts Entrepreneurship Education

In this study, we explored the intersection of performing arts and entrepreneurship through an autoethnographic study of a new arts venture, theLAB*, which participated in the Von Allmen Center for Entrepreneurship's accelerator program at the University of Kentucky. In creating theLAB*, we investigated the feasibility of establishing a dance-forward performing arts presenting organization within a profit-driven entrepreneurial ecosystem. As a multi-generational team of arts managers, we analyzed the experience utilizing scenario-planning and the DIEP (Describe, Interpret, Evaluate, Plan) model of reflection to assess the challenges and benefits of participating in this environment. Key findings reveal a significant disconnect between the …

Biophysical Simulation Enables Segmentation And Nervous System Atlas Mapping For Image First Spatial Omics, Lina Mohammed Ali, Aldrin Kay Yuen Yim, Emanuel Gerbi, Thien Nguyen, Nicholas Tu, Faith Ikede, Remi Sampaleanu, Diana Grigore, Jason Waligorski, Colin Kremitzki, Liya Yuan, Wendy Dong, Robi Mitra, Jeffrey Milbrandt, William Buchser

2020-Current year OA Pubs

Spatial omics (SO) produces high-definition mapping of subcellular molecules within tissue samples. Mapping transcripts to anatomical regions requires segmentation, but this remains challenging in tissue cross-sections with tubular structures like axons in peripheral nerve or spinal cord. Neural networks could address misidentification but are hindered by the need for extensive human annotations. We present SiDoLa-NS (Simulate, Don't Label-Nervous System), an image-driven (top-down) approach to SO analysis in the nervous system. We utilize biophysical properties of tissue architectures to design synthetic images of tissue samples, eliminating reliance on manual annotation and enabling scalable training data generation. With synthetic samples, we trained …

Protocols For Antioxidant Testing: A Mini Review Of Common Assays And Approaches, Abdulsalam Halboup, Sameer A. Alkubati

AUIQ Complementary Biological System

Antioxidants play a pivotal role in mitigating damage caused by oxidative stress, which is implicated in aging, inflammation, neurodegeneration, and various chronic diseases. With the growing interest in natural and synthetic antioxidants across nutraceutical, pharmaceutical, and food industries, the need for reliable, reproducible, and standardized testing methods has become increasingly urgent. This mini-review provides a structured overview of the most widely used antioxidant testing protocols, categorized into in vitro chemical-based assays (e.g., DPPH, ABTS, FRAP, metal chelation), cell-based assays (e.g., DCFH-DA for intracellular ROS detection), and in vivo biomarker-based models. Each method’s principle, experimental protocol, advantages, and limitations are critically …

Prevalence Of Giardia Infection: A Cross-Sectional Study In Basra Province, Iraq, Sarah Kamal Naser

AUIQ Complementary Biological System

Giardiasis is a common parasite infection that is seen more frequently than any other parasitic infection worldwide. This infection is especially prevalent in tropical areas and in developing nations that have a poor standard of living and poor health conditions. The Giardia parasite is able to infect people of any gender, as it enters the body by the mouth, passes down the oesophagus, and finally reaches the stomach, where it is not negatively impacted by gastric acids. The goal of this study is to determine the extent to which patients who were treated at Al-Zubair General Hospital in Basra, Iraq, …

Application Of Adversarial Volumetric Cnns To 3d Face Generation Using Latent Space Gaussian Embeddings, Ali Raad Abdulkareem, Marwa Jabberi, Islem Jarraya, Tarek M. Hamdani, Khmaies Ouahada, Adel M. Alimi

Iraqi Journal for Computer Science and Mathematics

Although 3D face generation is extensively studied in computer vision, most existing methods prioritize reconstructing 3D geometry from available 2D or 3D inputs rather than generating novel faces directly from latent representations. To bridge this gap, we present the application of Adversarial Volumetric Convolutional Neural Networks (AVCNN), a tailored adaptation of the vanilla 3D Generative Adversarial Network (3D-GAN), to 3D face generation using latent space Gaussian embeddings. We first assemble a custom 3D facial dataset to provide the requisite facial characteristics and to ensure sufficient coverage of geometric variation across identities. The generator, implemented as a decoder, maps latent space …

Midlife, Michael Sevcik

Poetry MFA Theses

Abstract

Midlife by Michael James Sevcik is a collection of poetry that explores issues of age, gender, sexuality, identity, desire, family, and loss within a predominantly domestic space while addressing broader social, cultural, and philosophical issues using a phenomenological poetics grounded in everyday experience. The collection is organized into three distinct yet interrelated “movements:” the first movement, “Anchored,” establishes an existential yearning amidst professional and amorous stasis and familial pressures. The second movement, “Liminal,” explores temporality and its relationship to place and memory. The third movement, “Renewal,” incorporates travel, family history, and art, transforming them into critical modes of aesthetic …

The Hidden World Of Evil: Documenting Serial Killers Through The Centuries, An Evolution., Semieca Wilson

Master of Arts in Human Services

The following is an analysis of the phenomenon of serial killers from their development over time, and why it mattered due to how they operated on society. Cases reported from the past to present century were read and analyzed in search of recurring psychological patterns, changes in methods of inspecting cases and the effects of cultural, technological transformation on both felons as well as those who trailed them. The site is a product of my professional interest in the area of criminal psychology and forensic analysis and reflects my objective to provide myself and other interested professionals, academics, law enforcement …

The Sexual Assault And Violence Experiences Questionnaire: Community-Developed Items For Gathering Sexual Violence Histories With Displaced Women, Meredith A. Blackwell

Psychology ETDs

Improving measurement of sexual violence has contributed to major policy changes in the United States. However, research on sexual violence largely overlooks those exposed to conflict and displacement: a population especially at risk. Assessment measures often ignore contextual features and use phrasing that is vulnerable to underreporting. This community-based participatory research project collaborated with cultural experts from Mexico/Central America and Afghanistan to develop a preliminary item list for a self-report measure of prior sexual violence. Analysis of focus group data from 30 women revealed a range of sexual violence experiences, and provided critical phrasing used to form an item list …

176th Commencement, Fall

Commencement Programs

Commencement program (graduate and undergraduate exercises) for fall 2025

Neurobehavioral Mechanisms Of Psychotic-Like Experiences And Cannabis Use, Ethan Campbell

Psychology ETDs

As cannabis use has increased steadily over the past decade, there is critical need to evaluate early cannabis use as a potential risk factor for the development of psychosis. Neurobehavioral mechanisms underlying novelty salience could clarify how cannabis exposure may influence subclinical psychotic-like experiences (PLEs). The present study leveraged dynamic functional connectivity and task-fMRI to assess the role of novelty processing in cannabis use and PLEs. A group of brain regions dynamically tied to the salience network while viewing short films were found to increase their activation as a function of stimulus novelty during a novelty bandit task. PLEs were …

Testing Tocqueville’S Troops: American Democracy At War In Mexico, Corbin V. Cali

History Theses

This thesis explores Alexis de Tocqueville's theory of democratic armies through the lens of the Mexican-American War (1846-1848), testing his predictions about how democratic social conditions influence military institutions and performance. Tocqueville argued that armies in democratic societies would face tensions between egalitarian ideals and military discipline, with citizen-soldiers resisting hierarchy while professional officers, often isolated from civil society, grew dangerously ambitious for war. He predicted that democratic armies would show energetic initiative but struggle with weak formal discipline, and that equality would fundamentally change the relationship between the military and the broader society. The Mexican-American War serves as an …

Guillaume Dustan's Ethico-Politics Of The Body, Noah Mertz

Foreign Languages & Literatures ETDs

In this MA Thesis, I lay out a synthetic overview of polemical French writer Guillaume Dustan's (1965-2005) political philosophy. He is criticized first as irresponsible and dangerous for his defense of barebacking (sex without condoms) in the midst of the AIDS epidemic, and then, after his death, as a neoliberal/anarcho-capitalist for his focus on individual liberty. My overview touches on Dustan's Freudian belief that repression is the root of all social ills, his functional ethics of self-responsibility, the revaluation of heteronormative Judeo-Christian morality towards 'virtusex,' and his social contract that minimizes repression. Dustan’s goal is for you to autonomously subjectify …

Using Vaginal Cytology To Confirm Estrus In Swine - Pilot Study, Carly J. Johnson

Honors College Theses

This study aims to determine whether there is a correlation between cellular changes observed in vaginal cytology and the physical signs of estrus in swine. Vaginal cytology is a technique commonly used in dogs, cats, and rodents, and if proven effective in swine, it could serve as a practical tool for producers to confirm estrus status and improve reproductive management.

Assessment Of Fish Community Dynamics, Movement, And Morphology In Relation To Stream Barriers In The Upper Illinois Bayou Watershed, Risa Mccollough

ATU Theses and Dissertations 2021 - Present

Intermittent streams are increasingly recognized as vital components of river networks by supporting dynamic fish communities shaped by variable hydrology and habitat connectivity. They are becoming increasingly vulnerable to fragmentation by anthropogenic activities, namely road crossings, dams, and climate shifts that intensify seasonal drying. In response, I conducted two studies in the Illinois Bayou watershed in Arkansas to assess the effects of fragmentation on fish community dynamics and morphology in intermittent streams.

In the first study, I examined temporal fish community dynamics across two barriers: a natural waterfall in Dare Creek and a low-water crossing in Dry Creek. Simultaneously, I …

Patient-Derived Ovarian Cancer Models Provide Insight Into Cancer Cell-Intrinsic And Immune Cell-Dependent Effects On Therapeutic Response, Parisa Nikeghbal

Biomedical Sciences ETDs

Ovarian cancer is the most lethal gynecologic malignancy, largely due to late diagnosis and resistance to chemotherapy. This dissertation applies patient-derived organoids (PDOs), xenograft-derived organoids (PDXOs), and humanized xenografts (huPDX) to investigate therapeutic responses and immune interactions. Organoids were shown to retain critical features of the original malignancy. Across platinum-sensitive, -resistant, and -refractory cases, both PDOs and PDXOs exhibited drug sensitivities that aligned with patients’ clinical classifications. Building on this foundation, a drug screen revealed novel strategies. Auranofin restored platinum sensitivity in Notch3-active models, afatinib broadly reduced viability, and adavosertib–gemcitabine and sorafenib–topotecan combinations produced synergy. Extending this work, immune interactions …

Recreating Fiber Recruitment With Fiber Recruitment Using Additive Manufacturing, Natalia D. Mciver

Biomedical Engineering ETDs

Injured ligaments are often repaired with tendon grafts which may over or under constrain the joint; there is a need for an artificial graft option with the mechanical properties of a native ligament. Crimped fibers within ligaments allow for recruitment which means the viscoelastic properties of stress relaxation and creep are not inversely related. A feasibility study using ACLs and large-scale crimp models to study viscoelasticity, led to an in-depth analysis of the scapholunate interosseous ligament. Using the Modified Kelvin spring-dashpot model, for describing viscoelasticity with a variable stiffness property (time dependent fiber recruitment), we defined the relationship between creep …

Stress During Adolescence: A Characterization Of Anxiety-Like Behavior, And The Mrna Expression Of Neuroimmune Factors, Clock And Stress Genes In Corticolimbic Areas., Annette Fernandez Oropeza, Annette K. Fernandez Oropeza

Biomedical Sciences ETDs

Adolescence represents a critical window of frontal cortex (FC) maturation and corticolimbic circuit refinement that supports stress and emotion regulation. Disruption of these processes by early-life insults such as prenatal alcohol exposure (PAE) or adolescent stress increases vulnerability to anxiety and mood disorders, in part through circadian–immune dysregulation. The circadian transcription factor Bmal1 and the proinflammatory cytokine tumor necrosis factor-alpha (TNFα) have emerged as key regulators of neuroimmune signaling and synaptic communication, yet their interactions across developmental risk contexts remain poorly understood. This dissertation examined the effects of mild adolescent isolation stress, with and without PAE, on anxiety-like behaviors and …

Listen To The Birds: Sound Ecology At The Piano, Anna Showalter

Dissertations, 2020-current

This document explores the intersection between birdsong and piano music using four cases studies from the piano repertoire in the Western classical tradition. Using Jeff Titon’s framework of “sound ecology” as a lens, I ask whether the following pieces of music could in some way function as an “acoustic tissue among human and bird communities that becomes the basis for a healthy economy and a just community.” After exploring the history of birdsong in the piano literature as a microcosm of shifting attitudes toward birdsong in Western art music this study focuses on four pieces as case studies for analysis—Amy …

Dynamic Admittance Parameterization For Non-Prehensile Multi-Robot Transport With Optimal Coordinated Planning, Calvin J. Stahoviak

Computer Science ETDs

The Dynamic Admittance Parameterization of Non-Prehensile Multi-Robot Trans- port with Optimal Coordinated Planning (DYNAMO) architecture offers a practical framework for cooperative payload transportation using two robots equipped with nonholonomic mobile bases and four-degree-of-freedom manipulators. Coordinated mobile manipulation is a difficult problem in robotics, and the non-prehensile case is even more challenging than its prehensile counterpart because the robot bases and the payload are dynamically coupled. DYNAMO adapts arm motion in response to interaction forces and generates coordinated base trajectories that account for this coupling. Robust payload transport is achieved through the combination of opti- mal planning and adaptive compliant control, …

The Pathophysiological Role Of Mitochondrial Acid-Sensing Ion Channel 1a In Hypoxic Pulmonary Hypertension, Megan N. Tuineau

Biomedical Sciences ETDs

Pulmonary hypertension (PH) is characterized by increased pulmonary arterial constriction, pulmonary arterial remodeling, and right ventricular dysfunction. While metabolic and mitochondrial derangements are increasingly recognized as central pathogenic features, the underlying mechanisms and effectors are not yet fully understood. Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel involved in the development of chronic hypoxia (CH)-induced PH. ASIC1a represents a potential candidate involved in metabolic-mitochondrial dysfunction, as metabolic byproducts can act as ligands for ASIC1a. Additionally, ASIC1a has recently been identified as a mitochondrial ion channel involved in neuronal death following oxidative stress. Therefore, we hypothesize that ASIC1a functions …