Digital Commons Network^™

Contribution To The Chemotherapy Of Human Trypanosomiasis: Design, Synthesis, And Biological Evaluation Of Dimeric 2-Nitroimidazoles Against Trypanosoma Cruzi Amastigotes And Bloodstream Trypanosoma Brucei, Afonso Santine M.M. Velez, Otavio Augusto Chaves, Carlos Serpa, Fatma M. Salem, Bibo Li Ph.D., Bin Su Ph.D., Celio Geraldo Freire-De-Lima, Debra Decote-Ricardo, Marco Edilson Freire De Lima

Biological, Geological, and Environmental Faculty Publications

Effective and safe treatments for neglected tropical diseases caused by parasites, such as Chagas disease and sleeping sickness, remain lacking, posing a significant challenge for researchers worldwide. The rational design of dimeric compounds inspired solely by the pharmacophoric core of benznidazole (2-nitroimidazole) has proven to be a promising strategy for antiparasitic development. Thus, in the present work, it was increased the linker between the active units (2-nitroimidazole) to improve the interaction with TcNTR, facilitating the bioactivation of the longest dimers. Biological assays confirmed this, demonstrating that all compounds were active against replicative intracellular amastigotes of Trypanosoma cruzi (Tulahuen C2C4-LacZ). Notably, …

Investigating The Knowledge, Attitudes And Practices Towards Type 2 Diabetes Mellitus In A Student Population In The United Kingdom: A Quantitative Study, Philip Boadu Anim

Theses

Aim: To explore the knowledge on the risk factors, signs and symptoms, management, and complications of Diabetes, attitudes, and practices towards prevention of Diabetes Mellitus among university students in the United Kingdom.

Methods: The researcher utilised a quantitative study design in carrying out the study. The study was conducted at Cardiff Metropolitan University with Cardiff Met students being the target population. Thirty (30) participants were recruited through convenient sampling. Data was collected through questionnaires using closed ended questions. The Statistical Package for Social Science (SPSS) version 27 as used to analyse the data collected. Statics were performed to form a …

Delegation And Agency Deference In Financial Regulation: A Comparative Eu-U.S. Perspective, Rosa M. Lastra, Patricia A. Mccoy

Law and Contemporary Problems

No abstract provided.

Alcohol And The Endocrine System: A Critical Review Of Disruptions, Potential Mechanisms, And Health Implications, Patricia E. Molina, Liz Simon

School of Graduate Studies Faculty Publications

The endocrine system coordinates and integrates cellular activity throughout the body by regulating cellular and organ function and maintaining homeostasis. Homeostasis, the dynamic maintenance of internal balance despite changing external or internal conditions, is essential for proper cellular function. The endocrine system achieves this through a complex regulatory network of hormone-mediated signaling among multiple endocrine organs, relying on precisely regulated synthesis and release of hormones and specific hormone-receptor interactions. Endocrine-mediated actions coordinate critical physiological processes, including growth, metabolism, reproduction, stress adaptation, and circadian rhythms throughout the lifespan. Endocrine glands—such as the hypothalamus, pituitary, thyroid, parathyroid glands, pancreas, adrenal glands, and …

Faith-Based Organizations In Foreign Aid (Forfa) Codebook, Susan Turner Haynes

Faculty Works

This codebook was designed to guide undergraduate students in coding the faith status of USAID Grant recipients and is being made available to facilitate further use in the classroom. Please contact the author for any inquiries ([email protected]).

Fda Policy Shift On Clinical Efficacy Study Requirements For Monoclonal Antibody Biosimilars, Rileigh Rahrig, Madilyn Paphanchith, Allie Honigford, Daniella Egbujor, Haley Brown, Jenny Magana Figueroa, Connor Dains, Brenna Hissong, Kyle W. Parker

Pharmacy and Wellness Review

Biologic products are widely used in the treatment of various disease states, including rheumatoid arthritis, inflammatory bowel disease, cancers, and genetic diseases. These products are derived from proteins and genes produced by living organisms and are subsequently used to treat specific disease states. Due to the complexity of biological products, the costs of research and production are high. Currently, the United States approval pathway requires extensive testing for biologics to be designated as biosimilars, meaning there are no clinically meaningful differences in safety or purity of their active components. These required tests can be redundant, as biosimilars are developed using …

Tumor-Infiltrating Bacteria Disrupt Cancer Epithelial Cell Interactions And Induce Cell-Cycle Arrest, Jorge Luis Galeano Niño, Falk Ponath, Victor A Ajisafe, Clara R Becker, Andrew G Kempchinsky, Martha A Zepeda-Rivera, Javier A Gomez, Hanrui Wu, Jessica G Terrazas, Heather Bouzek, Elizabeth Cromwell, Pritha Chanana, Matthew Wong, Ashish Damania, Michael G White, Y Nancy You, Scott Kopetz, Nadim J Ajami, Jennifer A Wargo, Christopher D Johnston, Susan Bullman

Faculty, Staff and Student Publications

Tumor-infiltrating bacteria are increasingly recognized as modulators of cancer progression and therapy resistance. We describe a mechanism by which extracellular intratumoral bacteria, including Fusobacterium, modulate cancer epithelial cell behavior. Spatial imaging and single-cell spatial transcriptomics show that these bacteria predominantly localize extracellularly within tumor microniches of colorectal and oral cancers, characterized by reduced cell density, transcriptional activity, and proliferation. In vitro, Fusobacterium nucleatum disrupts epithelial contacts, inducing G0-G1 arrest and transcriptional quiescence. This state confers 5-fluorouracil resistance and remodels the tumor microenvironment. Findings were validated by live-cell imaging, spatial profiling, mouse models, and a 52-patient colorectal cancer cohort. Transcriptomics reveals …

Spatial Omics At The Forefront: Emerging Technologies, Analytical Innovations, And Clinical Applications, Yunhe Liu, Yibo Dai, Linghua Wang

Faculty, Staff and Student Publications

Spatial omics transforms our understanding of cancer by revealing how tumor cells and the microenvironment are organized, interact, and evolve within tissues. Here, we synthesize advances in spatial technologies that map tumor ecosystems with unprecedented fidelity. We highlighted analytical breakthroughs-including multimodal integration and emerging spatial foundation models-that resolve functional niches and spatial communities, converting spatial patterns into mechanistic insights. We summarize how spatially organized features, from immune hubs to microbiota and neural interfaces, shape tumor evolution and clinical outcomes. We then outline how spatial approaches illuminate precancer biology, metastatic adaptation, and therapy response. Bridging discovery and translation, we provide a …

Tet2-Mutant Clonal Hematopoiesis Enhances Macrophage Antigen Presentation And Improves Immune Checkpoint Therapy In Solid Tumors, Shelley Herbrich, Mehdi Chaib, Swetha Anandhan, Samuel W Andrewes, Ashwat Nagarajan, Baoxiang Guan, Nishant Gandhi, Jared Gilliam, Milan Radovich, Padmanee Sharma

Faculty, Staff and Student Publications

Clonal hematopoiesis (CH) is detectable in upwards of 20% of patients with solid tumors and is associated with worsened prognosis; however, its role in tumor immunology and immune checkpoint therapy (ICT) is unknown. Using a bone marrow chimera model of Tet2+/mut CH in mice with solid tumors, we found the Tet2-mutant myeloid cells are abundant in the tumor microenvironment and contributed to an improved response to ICT. Mechanistically, Tet2+/mut macrophages inside the tumor act as immunogenic antigen-presenting cells that more effectively cross-prime naive CD8+ T cells in response to IFNγ. In human cohorts of 35,971 non-small cell lung cancer patients …

Adipose Stromal Cell-Derived Cancer-Associated Fibroblasts Promote Pancreatic Adenocarcinoma Progression Through Sfrp4 Signaling, Joseph Rupert, Lingyi Cai, Alexes C Daquinag, Dimitris Anastassiou, Mikhail G Kolonin

Faculty, Staff and Student Publications

Background/objectives: Progression of pancreatic ductal adenocarcinoma (PDAC) and other carcinomas relies on cancer-associated fibroblasts (CAFs). A subset of CAFs is derived from adipose stromal cells (ASCs) recruited by tumors and the ASC-CAF conversion has been associated with invasiveness and poor prognosis.

Methods: To explore the underlying molecular mechanisms, we used a model based on primary ASCs derived from human visceral adipose tissue co-cultured with human PDAC cell line Capan-1. To investigate cancer progression in vivo, we also used mice orthotopically grafted with mouse KPC cells.

Results: Genomic analysis revealed that Capan-1 co-culture induces Wnt and TGFβ signaling and extracellular matrix …

Chek2 Loss Endows Chemotherapy Resistance To Hematopoietic Stem Cells, Jing Zhou, Tianyuan Hu, Dian Li, Sanming Li, Minhua Li, Xiangguo Shi, Daisuke Nakada

Faculty, Staff and Students Publications

Individuals with history of chemo- or radiotherapy frequently exhibit somatic mosaicism in the blood, often involving mutations in genes responsible for DNA damage responses (DDR), such as CHEK2. However, the mechanisms by which CHEK2 mutations promote the expansion of mutant cells following chemo- or radiotherapy remain poorly understood. Here, we demonstrate that loss of CHEK2 confers resistance to chemotherapy in hematopoietic stem and progenitor cells (HSPCs). Through a CRISPR-based screen, we identified CHEK2 as a gene whose loss enhances resistance to cytotoxic chemotherapies. A complementary drug screen revealed that CHEK2-mutant cells are also resistant to DNA hypomethylating agents. Chek2-deficient HSPCs …

Assessing Localized Recovery And Synchrony Of An Endangered Wetland Species., Aiyana Reissman

Theses

The state and federally endangered light-footed Ridgway’s rail (LFRR; Rallus obsoletus levipes) is central to regional conservation, yet the drivers of its population fluctuations remain poorly understood. The fragmented nature of coastal wetlands in Southern California is threatening the existence of endemic species like the LFRR. Tidal inundation, severe storms, and overpredation threaten the survival of LFRR. This study addresses population fluctuations by analyzing the spatial and temporal drivers of LFRR populations to inform effective, site-specific management.

To do this, a 45-year (1980–2024) LFRR census data set across 16 wetlands throughout its range in California was synthesized. A multi-faceted …

Optimal Drought Management Actions For Cattle Operations On Navajo Nation, Tatiana Drugova, Kynda R. Curtis, Man-Keun Kim

All Current Publications

In this fact sheet, we examine the drought management options available to cattle operations on the Navajo Nation, the largest Native American reservation in the U.S. Specifically, we discuss the results of a study evaluating the economic outcomes of two common drought response strategies: herd reduction and supplemental hay purchases. We also provide recommendations for ranchers on optimal strategies, i.e., those that maximize profits, for two rancher types, differentiated by their willingness to accept (risk-neutral) or avoid risk (risk-averse).

Optimal Quantization Of Finite Uniform Data On The Sphere, Mrinal Kanti Roychowdhury

School of Mathematical & Statistical Sciences Faculty Publications

This paper develops a systematic and geometric theory of optimal quantization on the unit sphere 𝕊2, focusing on finite uniform probability distributions supported on the spherical surface—rather than on lower-dimensional geodesic subsets such as circles or arcs. We first establish the existence of optimal sets of n-means and characterize them through centroidal spherical Voronoi tessellations. Three fundamental structural results are obtained. First, a cluster-purity theorem shows that when the support consists of well-separated components, each optimal Voronoi region remains confined to a single component. Second, a ring allocation (discrete water-filling) theorem provides an explicit rule describing how optimal representatives are …

Smart Recurring Payment Auditor For Bait-And-Switch Mitigation, Prajna Shetty, Alok Roy

Defensive Publications Series

The present disclosure relates to the field of digital payment security, in particular to a system and method for mitigating bait-and-switch practices in recurring digital payment systems. The smart recurring payment auditor disclosed herein operates at a network layer of the payment infrastructure. The smart recurring payment auditor employs a multi-modal deep learning ensemble, advanced bitmapped feature encoding and temporal pattern synthesis to analyse recurring payment behaviour. Further, the smart recurring payment auditor integrates global merchant telemetry, user behavioural feedback, and descriptor intelligence to detect and score deceptive recurring billing schemes. Furthermore, upon identification of a suspicious pattern, the smart …

Non-Invasive Monitoring Of Camel Hair From A Free-Grazing Herd As A Biomarker In Linking Environmental Exposure And Nutritional Status In Desert Ecosystems, Ibrahim Albokhadaim

The Thai Journal of Veterinary Medicine

Camels are vital livestock in arid regions, yet their elemental exposure remains underexplored, particularly through non-invasive biomarkers. This study is novel in applying camel hair as a non-invasive, long-term biomarker to assess nutritional adequacy and environmental exposure in a free-grazing desert herd, with age-stratified evaluation of essential and toxic element accumulation. For this purpose, a cross-sectional study was conducted on a herd of 18 apparently healthy camels (≤6 months: 28%; >6 months: 72%). Initially, hair samples were collected, washed, digested, and analyzed using inductively coupled plasma mass spectrometry (ICP-MS). The samples were then analyzed to determine the concentrations of 12 …

Enhancing Wound Healing With Synergistic Dual-Drug Electrospun Roflumilast And L-Arginine Loaded Pla/Pva Nanofibers Through Fabrication, Optimization, And In Vivo Assessment, Samar A. Salim

Nanotechnology Research Centre

Current trends in improved wound management emphasize the development of dual-drug-loaded electrospun nanofibrous scaffolds. Herein, electrospun dual-drug loaded PLA/PVA nanofibrous scaffolds, incorporating roflumilast, a selective phosphodiesterase-4 inhibitor with anti-inflammatory activity, and L-arginine, a precursor to nitric oxide with stimulating activity towards wound healing and tissue regeneration, were developed. A dual-spinneret electrospinning process enabled the coloading of drugs in PLA and PVA phases. Scaffolds were characterized by SEM, FTIR, and XRD, showing consistent fiber morphology, and amorphous drug formation. FTIR analysis was performed to confirm drug–polymer compatibility and successful incorporation of roflumilast and L-arginine within the PLA/ PVA nanofibrous matrix. Swelling …

Blood Product Transfusion And Coagulopathy In Children With Traumatic Brain Injury: A Narrative Review., Robert Marcel T. Huibonhoa, Niranjan Vijayakumar, Daniel Kelly, Oliver Karam, Madhuradhar Chegondi

Manuscripts, Articles, Book Chapters and Other Papers

Traumatic brain injury (TBI) is a leading cause of critical illness and mortality in children. Transfusion of blood products, a common intervention in the management of pediatric TBI, has important implications for related principles, including trauma-induced coagulopathy, cerebral perfusion, and cerebral oxygen delivery. Knowledge gaps persist due to the limited availability of pediatric-specific data regarding blood product transfusion in TBI. In particular, there is a lack of prospective studies defining appropriate specific laboratory thresholds and transfusion targets, as well as insufficient evidence to guide the weighing of potential benefits against transfusion-related risks in this population. Although blood product transfusion in …

Only One Percent Of Important Shark And Ray Areas In The Western Indian Ocean Are Fully Protected From Fishing Pressure, Jesse E.M. Cochran, Ryan Charles, Andrew J. Temple, Peter M. Kyne, Emiliano García-Rodríguez, Adriana Gonzalez-Pestana, Amanda Batlle-Morera, Théophile L. Mouton, Asia O. Armstrong, Christoph A. Rohner, Darren J. Coker, Royale S. Hardenstine, Alexander Kattan, Ashlie J. Mcivor, Viktor Nunes Peinemann, Kaitlyn A. O'Toole, Lea Palm, Eloise B. Richardson, David A. Ebert, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

The Western Indian Ocean (WIO) is known for its high diversity of chondrichthyans (sharks, rays, and chimaeras). However, intense fishing pressure has led to severe population declines and local extinctions of several species. The Important Shark and Ray Area (ISRA) process is a collaborative, evidence-based approach used to identify critical habitat for chondrichthyans. We analysed ISRAs across the WIO to quantify the diversity of research methods used to identify them, evaluate spatial overlap with designated marine protected areas (MPAs), model the influence of several species- and jurisdiction-specific variables on ISRA delineation, and explore the importance of incorporating unpublished data into …

Only One Percent Of Important Shark And Ray Areas In The Western Indian Ocean Are Fully Protected From Fishing Pressure, Jesse E. M. Cochran, Ryan Charles, Andrew J. Temple, Peter M. Kyne, Emiliano García‐Rodríguez, Adriana Gonzalez‐Pestana, Amanda Batlle‐Morera, Théophile L. Mouton, Asia O. Armstrong, Christoph A. Rohner, Darren J. Coker, Royale S. Hardenstine, Alexander Kattan, Ashlie J. Mcivor, Viktor Nunes Peinemann, Kaitlyn A. O'Toole, Lea Palm, Eloise B. Richardson, Kalli Valappil Akhilesh, Haleh Ali Abedi, Reem K. Almealla, Dareen Almojil, Samantha Andrzejaczek, Arzucan N. Askin, Avik A. Banerjee, Hamid R. Bargahi, Alissa J. Barnes, Svetlana Barteneva‐Vitry, Siamak Behzadi, Aymeric Bein

School of Biological and Marine Sciences

The Western Indian Ocean (WIO) is known for its high diversity of chondrichthyans (sharks, rays, and chimaeras). However, intense fishing pressure has led to severe population declines and local extinctions of several species. The Important Shark and Ray Area (ISRA) process is a collaborative, evidence-based approach used to identify critical habitat for chondrichthyans. We analysed ISRAs across the WIO to quantify the diversity of research methods used to identify them, evaluate spatial overlap with designated marine protected areas (MPAs), model the influence of several species- and jurisdiction-specific variables on ISRA delineation, and explore the importance of incorporating unpublished data into …

Perception As Beholding: Theological Possibility And Moral Implication Of Merleau-Ponty's Notion Of Embodied Subject, Erickson L. Totanes

Budhi: A Journal of Ideas and Culture

In this article, I argue that Merleau -Ponty’s concept of perception reveals a way of seeing where the subject is involved with the object in a dynamic, reversible, and expanding relationship. This notion challenges the traditional and Cartesian subject -object dichotomy by emphasizing the embodied and lived experience of perception which elicits a process, a way of looking, anticipating, and reflexively, a way of being itself. By aligning seeing with beholding, I attempt to show how as simple an act as seein g evokes a manner of being related to an object, other people, and the world. The emergence of …

Surf And Turf: How Litigation Against Concentrated Animal Feeding Operations Can Inform Regulation Of The Aquaculture Industry, Amanda Kapitula

Pace Environmental Law Review

Industrial agriculture dominates the U.S. agricultural industry. On land, animals are stuffed into factory-like facilities, called concentrated animal feeding operations (“CAFOs”), where they are raised to maximize the output of food products. In the process, they produce vast amounts of waste, contaminating surrounding air and water resources. Increasingly, factory farms are making their way into the water as the fishing industry shifts from wild-catch systems to aquaculture operations, or the raising of fish for consumption. While aquaculture has the potential to be a more sustainable option than both wild-catch and animal agriculture, concentrated aquatic animal production facilities (“CAAPFs”) also have …

Reclaiming My Story: A Freirean Framework For Surviving Trauma And Transforming Recovery Into Liberation, Carl Bryan

The Interactive Journal of Global Leadership and Learning

This white paper explores trauma recovery through the lens of Paulo Freire’s Pedagogy of the Oppressed (1970/2018), framing healing as an act of critical consciousness and liberation rather than passive survival. Using the author’s lived experience of stalking, manipulation, and emotional abuse as a case study, it reimagines recovery not as a return to normalcy but as a dialectical process of reclaiming narrative agency, reconstructing identity, and transforming pain into purpose. Drawing upon Freirean concepts of conscientização (critical consciousness), dialogue, and praxis, the paper outlines a model for survivors to move from internalized oppression toward empowerment and social transformation.

Major Gift From Alumnus Promotes Excellence In Stem Teaching, Bill Dabney

University of Mississippi News

OXFORD, Miss. – University of Mississippi medical school graduate Dr. Bill Ashford and his wife, Leslie, of Madison, have made a $2 million donation to establish a named professorship in physics at Ole Miss.

Effect Of Remineralization And Resin Infiltration On Microhardness, Mineral Content And Cervical Microleakage Of Restored Demineralized Enamel, Sara Adel Botros, Caroline Maged Massieh

Dentistry

No abstract provided.

Comparing Power Outputs Of A Jump Shrug With A Hex Bar Vs A Straight Bar, Joshua Neumann

Doctorate in Kinesiology

The purpose of this dissertation was to examine whether barbell selection influenced power outputs during loaded jump shrugs in collegiate athletes and to connect research findings to practical applications in strength and conditioning. Although Trap Bars are often assumed to provide mechanical advantages during explosive lifts, limited research has evaluated their impact during ballistic derivatives such as jump shrugs. This study addressed that gap by comparing the performance of Straight Bar and Trap Bar exercises across four standardized loads in male and female Division II athletes. A repeated-measures design was used to assess barbell velocity, concentric mean power, peak landing …

Identification Of Cadm1 As An Immunotherapeutic Target And Evaluation Of A Novel Cadm1-Targeting Antibody-Drug Conjugate In Preclinical Osteosarcoma Models, Yifei Wang, Zhongting Zhang, Caterina Longo, Wendong Zhang, Qi Wang, Amer Najjar, Xiangjun Tian, Rossana N Lazcano Segura, Michael E Roth, Jonathan Gill, Douglas J Harrison, Zhaohui Xu, Yanhua Yi, Xin Zhou, Sylvester Jusu, Timothy M Stearns, Steven B Neuhauser, Carol J Bult, Jing Wang, Alexander J Lazar, Richard Gorlick

Faculty, Staff and Student Publications

Due to the paucity of validated cell surface osteosarcoma-specific targets, patients with this condition have long been excluded from the benefits of antibody-drug conjugate (ADC) therapy observed in patients with several solid and hematologic malignancies. Our comprehensive surfaceome profiling approach previously identified osteosarcoma-specific cell-surface antigens that are highly expressed in osteosarcomas but minimally expressed in normal tissues. As a result, one such antigen, CADM1, was selected for the generation of an ADC. We tested a CADM1-targeting ADC with a tesirine payload (SG3249) in vitro in osteosarcoma, rhabdomyosarcoma, and neuroblastoma patient-derived xenograft cell lines. In vivo, we tested six CADM1-expressing osteosarcoma …

The Computationally Designed Tri2-2 Miniprotein Inhibitor Protects Against Multiple Sars-Cov-2 Omicron Variants, Jimin Lee, James Brett Case, Young-Jun Park, Rashmi Ravichandran, Daniel Asarnow, M Alejandra Tortorici, Jack T Brown, Shilpa Sanapala, Lauren Carter, David Baker, Michael S Diamond, David Veesler

2020-Current year OA Pubs

The continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has compromised neutralizing antibody responses elicited by prior infection or vaccination and abolished the utility of most monoclonal antibody therapeutics. We previously described a computationally-designed, homotrimeric miniprotein inhibitor, designated TRI2-2, that protects mice against pre-Omicron SARS-CoV-2 variants. Here, we show that TRI2-2 exhibits broadly neutralizing activity of SARS-CoV-2 variants and protects mice against BQ.1.1, XBB.1.5 and BA.2.86 challenge when administered intranasally post-exposure. The resistance of TRI2-2 to viral escape by most variants and the ability to deliver it directly to the upper airways highlight the potential of the multivalent …

Transcriptomic Signature-Guided Depletion Of Intermediate Alveolar Epithelial Cells Ameliorates Pulmonary Fibrosis In Mice, Fei Peng, Chun-Sun Jiang, Zhen Zheng, Shahram Aliyari, Dan Shan, Aaryan Sabharwal, Qinyan Yin, Shigeki Saito, Chao He, Ivan O Rosas, Joseph A Lasky, Victor J Thannickal, Yong Zhou

Faculty, Staff and Students Publications

Single-cell RNA sequencing (scRNA-seq) has identified intermediate epithelial states in pulmonary fibrosis, including KRT5-/KRT17+ aberrant basaloid cells in humans and Krt8+ alveolar differentiation intermediates (ADIs) in mice. Their functional contributions to fibrogenesis, however, remain unclear. Here, we introduce an RNA-sensing-dependent protein translation technology that enables selective targeting of Krt8+ ADI cells in vitro and in vivo. Transcriptomic analysis revealed Small Proline-Rich Protein 1 A (SPRR1A) mRNA as a shared marker of murine Krt8+ ADIs and human KRT5-/KRT17+ basaloid cells, distinguishing them from other lung cell populations. Using programmable RNA sensors, we demonstrated selective EGFP-labeling of Krt8+ ADI cells in vivo, …

The Archon, 1957 Edition, Zeta Phi Beta Sorority Incorporated

Josie Green Washington Papers

A 1957 edition pamphlet called The Archon, an official organ of the Zeta Phi Beta Sorority.