Digital Commons Network^™

Capturing The Spirit Of Childhood: An Analysis Of Robert Henri’S Portraits Of Children, Alex C. Maccaro

Theses and Dissertations

Robert Henri (1865-1929) is perhaps best known as the prominent leader of the turn-of-the century American movement The Eight, commonly known as “the Ashcan School,” and as a leading teacher in the United States during the early twentieth century. However, his artistic output as a portrait painter, particularly of children, is also significant. Beginning in 1904 and throughout his career as an artist, Henri painted hundreds of images of children in the various foreign or remote locales to which he traveled, often depicting the same subject in multiple instances. These portraits range from the roughly painted, rosy-cheeked Dutch youth of …

Circadian-Shaped Immune Variability Predicts Infection Outcome, Jonathan Lalsiamthara, Mariko Locke, Alejandro Aballay

Faculty, Staff and Student Publications

Disease risk and severity are influenced by genetics, epigenetics, and environmental factors. However, immune responses vary even among genetically similar or related individuals, shaped by inherited and noninherited factors. Using Caenorhabditis elegans, we found that pathogen susceptibility can be predicted by preinfection biomarkers. Individuals with high-basal expression of irg-5, an infection response gene regulated by the p38 mitogen-activated protein kinase-1 (PMK-1) pathway, were more susceptible to Pseudomonas aeruginosa infection. A genome-wide screen identified the myeloid ecotropic viral integration site-1 (MEIS) homeobox protein UNC-62 as a regulator of irg-5 expression, acting through PMK-1 and GATA binding erythroid-like transcription factor …

Cognitive And Economic Development, John Luke Gallup

Economics Faculty Publications and Presentations

A burgeoning literature has found that early childhood health conditions of individuals have large causal effects on their cognitive development, education and earnings. How much does early cognitive development contribute to the national economy? Although researchers have long studied the role of worker health for economic growth, they have not assessed the role of early cognitive development.

Cognitive ability is the foundation of human capital, affecting both educational attainment and economic growth. The risk factors for poor cognitive development are very high in many countries. Each risk factor also causes child mortality, making child survival a viable proxy for good …

Impaired Complement Regulation Drives Chronic Lung Allograft Dysfunction After Lung Transplantation, Hrishikesh S. Kulkarni, Laneshia K. Tague, Fuyi Liao, Zhiyi Liu, Lorena Garnica, Nishanth R. Shankar, Xiaobo Wu, Dequan Zhou, Yan Tao, Victoria E. Davis, Cory T. Bernardt, Derek E. Byers, Chad A. Witt, Daniel Kreisel, John P. Atkinson, Andrew E. Gelman, Et Al.

2020-Current year OA Pubs

A greater understanding of chronic lung allograft dysfunction (CLAD) pathobiology, the primary cause of death after lung transplantation (LTx), is needed to improve outcomes. The complement system links innate to adaptive immune responses and is activated early after lung transplantation to form C3 convertase, a critical enzyme that cleaves the central complement component C3. We hypothesized that LTx recipients with a genetic predisposition to enhanced complement activation have worse CLAD-free survival mediated through increased adaptive alloimmunity. We interrogated a known functional C3 polymorphism (C3 R102G) that increases complement activation through impaired C3 convertase inactivation in 2 independent LTx recipient cohorts. …

Cholesterol Efflux Protein, Abca1, Supports Anticancer Functions Of Myeloid Immune Cells, Shruti V Bendre, Yu Wang, Basel Hajyousif, Rajendra K C, Shounak G Bhogale, Dhanya Pradeep, Natalia Krawczynska, Claire P Schane, Erin Weisser, Avni Singh, Simon Han, Hannah Kim, Lara Kockaya, Anasuya Das Gupta, Adam T Nelczyk, Hashni Epa Vidana Gamage, Yifan Fei, Desirée Rodríguez-Casiano, Xingyu Guo, Haoyun Li, Ryan J Deaton, Fei Mo, Maria Sverdlov, Peter H Gann, Saurabh Sinha, Sahil Sahni, Kun Wang, Kevin Van Bortle, Emad Tajkorshid, Wendy A Woodward, Wonhwa Cho, Erik R Nelson

Faculty, Staff and Student Publications

Breast and other solid tumors respond poorly to immune therapy. Myeloid cells (MCs) such as macrophages contribute to resistance. Established clinical evidence links cholesterol to cancer outcomes, with MC function being regulated by cholesterol metabolism. We screened MC-expressed regulators of cholesterol homeostasis linked to survival and identified the cholesterol efflux protein ABCA1. ABCA1 activity increases anticancer functions of macrophages: enhancing tumor infiltration, decreasing angiogenic potential, reducing efferocytosis, and improving support of CD8+ T cell activity. Mechanistically, different AKT isoforms are involved, through both PI3K-dependent and PI3K-independent mechanisms. Highlighting the clinical relevance of our findings are correlations between ABCA1 in macrophages …

Nf2 Loss Malignantly Transforms Human Pancreatic Acinar Cells And Enhances Cell Fitness Under Environmental Stress, Yi Xu, Michael H Nipper, Angel A Dominguez, Chenhui He, Francis E Sharkey, Sajid Khan, Han Xu, Daohong Zhou, Lei Zheng, Yu Luan, Jun Liu, Pei Wang

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) occurs as a complex, multifaceted event driven by the interplay of tumor-permissive genetic mutations, the nature of the cellular origin, and microenvironmental stress. In this study, using primary human pancreatic acinar 3D organoids, we performed a CRISPR-KO screen targeting 199 potential tumor suppressors curated from clinical PDAC samples. Our data revealed significant enrichment of a list of candidate genes, with neurofibromatosis type 2 associated gene (NF2) emerging as the top target. Functional validation confirmed that loss of NF2 promoted the transition of PDAC to an invasive state, potentially through extracellular matrix modulation. NF2 inactivation …

Peroxisomal Integrity In Demyelination-Associated Microglia Enables Cellular Debris Clearance And Myelin Renewal In Mice, Joseph A Barnes-Vélez, Xiaohong Zhang, Yaren L Peña Señeriz, Kiersten A Scott, Yinglu Guan, Jian Hu

Faculty, Staff and Student Publications

Demyelination associated microglia (DMAM) orchestrate the regenerative response to demyelination by clearing myelin debris and promoting oligodendrocyte maturation. Peroxisomal metabolism has emerged as a candidate regulator of DMAMs, though the cell-intrinsic contribution in microglia remains undefined. Here we elucidate the role of peroxisome integrity in DMAMs, using cuprizone-mediated demyelination coupled with conditional KO of peroxisome biogenesis factor 5 (PEX5) in microglia. Absent demyelination, PEX5 conditional KO (PEX5cKO) had minimal impact on homeostatic microglia. However, during cuprizone-induced demyelination, the emergence of DMAMs unmasked a critical requirement for peroxisome integrity. At peak demyelination, PEX5cKO DMAMs exhibited increased lipid droplet burden and reduced …

Failed Retrieval Of An Inferior Vena Cava Filter, Robert B. Murrell, Mitchell Fisher, Christopher Stewart, George Ladas, Samuel Groot, Austin Wagner, Suporn Sukpraprut-Braaten

Student Publications

Inferior vena cava (IVC) filters are devices used to lower the risk of critical pulmonary embolisms in patients with current deep vein thrombosis (DVT) or a high risk of developing such. These devices are used especially when there are contraindications to anticoagulants or when conservative therapy has failed. Typically, IVC filters are temporary and can be retrieved upon improvement in the patient's clotting status.

This case presents a 75-year-old female whose IVC filter retrieval failed. Once cleared by both cardiology and orthopedics, the decision was made to retrieve the IVC filter. First attempts at retrieval proved unsuccessful as the IVC …

Upcycle Of Used Jute Sacks For Production Of Shoes And Bags As Fashion Accessories, Solomon Gausa Dr., Ruth Adumna Ahmed, Muhammad Sani Yahaya Dr., Dymphna Bakker-Edoh Dr

Jurnal Sosial Humaniora Terapan

The study aims to upcycle used jute sacks into fashion accessories for sub-Saharan Africa, particularly Nigeria. The approach employs innovative design techniques and manufacturing processes that improve both the aesthetic appeal and environmental impact of jute products. To achieve the study's objectives, a design and development research approach was used to support an iterative process. A structured interview guide collected data from fifteen respondents. The study used thematic analysis by coding both open and axial codes, which were selected and grouped according to the objective to reach the final results before interpreting and translating the findings into a developed design …

Study On Visualization Simulation And System Dynamic Optimization Of The Ore Drawing Process In Mine Chutes, Liang Juan, Zhu Quanjie, Hao Yingnan, Quan Zhongxue, Zhang Zhiwu, Liu Xiaohuic, Ouyang Zhihua

Journal of Sustainable Mining

The ore release process in metal mine chutes is a critical part of the mining operation. Based on the urgent demand for intelligent mining construction, this paper proposes a visualization simulation and dynamic optimization method for the mine chute ore release process using the open-source programs Python and Blender. The main research content includes: designing the simulation method and model for the ore release process, including the main control program, process subprograms, etc.; proposing a visualization simulation method for the mine chute ore release process based on Blender, studying the impact of ore shape and size on ore release efficiency, …

Assessment Of Heavy Metal Contamination In Surface Water Near Tailings Dam, Gera Techane Mengistu, Tesema Kebede, Enatfenta Melaku, Engdasew Temere

Journal of Sustainable Mining

Elevated levels of heavy metals in surface water can lead to the degradation of water quality, especially in mining areas where tailing dams are sources of heavy metal pollution. This study focuses on evaluating the concentrations of heavy metals in surface water near the Legadembi tailings dams. The mean concentrations (in µg/L) of various heavy metals including: arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), mercury (Hg), molybdenum (Mo), nickel (Ni), lead (Pb), antimony (Sb), selenium (Se), thallium (Tl), uranium (U), vanadium (V), tungsten (W), zinc (Zn), and zirconium (Zr) were determined: 79.7, 0.15, 162.3, 0.66, 18.1, 0.01, …

Continuous Sorption Of Ionic Dyes Onto Nanoporous Faujasite Zeolite And The Regeneration Of The Adsorbent, Frederick O. Oshomogho, Miracle Aisosa Omorogieva

BAU Journal - Science and Technology

This study evaluates the efficiency of synthesized faujasite zeolite in the continuous removal of methylene blue from water and tests the reusability of the regenerated adsorbent. Faujasite Zeolite was synthesized from locally available aluminosilicate clay in Edo State using standard methods documented in the literature. XRF analysis affirmed the elemental composition, showing high levels of silica and alumina, which increased its adsorption capacity. SEM images depicted a crystal-clear structure with an octahedral shape and visible micro-pores on the surface. TGA showed effective thermal stability below 300 ºC, with a 10% weight loss between 28.59 ºC and 300 ºC. BET analysis …

The Prophylactic Effect Of Aqueous Chamomile Extract On Nitrogen Dioxide Exposed Mice, Mariam Kbaysi, Ruzanna Petrosyan, Jamilah Borjac

BAU Journal - Science and Technology

Nitrogen dioxide (NO₂) a gaseous air pollutant resulting from industrial activities. It has been associated to various diseases related to oxidative stress and inflammation, including cardiovascular and nervous system disorders. Chamomile is mainly recognized for its high content of antioxidant flavonoids and is extensively utilized in herbal medicine for treating several disorders. The aim of this study is to examen the protective effects of chamomile extract against NO₂-induced damage in female mice. Balb/c mice were divided into four groups: control, chamomile extract, NO₂ derivatives, and NO₂ derivatives combined with chamomile extract. Upon completion of the study, Blood was …

Exploring Alkaline Protease Activity Of Bacillus Strain Isolated From Sidon Dumpsite Lebanon, Zahra Farroukh, Dalia El-Badan, Jamilah Borjac

BAU Journal - Science and Technology

Proteases are crucial hydrolytic enzymes present in all organisms, performing essential physiological and industrial tasks. This study was conducted to screen and isolate protease-producing bacteria from soil and water samples collected from Sidon dumpsite in Lebanon. Bacterial samples were cultured onto skim milk agar medium to identify the alkaline protease-producing ones. In this study, we report on the partial purification and characterization of one of the isolated alkaline protease-producing bacteria. The bacterium was identified as Bacillus subtilis Z3 based on 16S rRNA sequencing. The molecular weight of the partially purified protease was approximately 55 kDa, estimated by sodium dodecyl sulphate …

Assessment Of Outdoor Thermal Human Comfort Over Houche Al-Oumara, North Lebanon, Ali Adnan Shaar, Ismail Ibrahim Abbas, Mahmoud Ahmed Hewehy, El-Sayed Mohamed Abdel-Hamid Robaa, Mohammed Salah El-Din Mostafa

BAU Journal - Science and Technology

This study examined thermal discomfort in Houche Al-Oumara between 1994 and 2021 using several discomfort indices and analyzing temperature, relative humidity, and rainfall data. The results showed that July and August recorded markedly higher mean temperatures than all other months, with July having the highest temperature overall. In contrast, January was identified as the coldest month. The study found a steady rise in mean air temperature from January to July, followed by a steady decline from July to December. Relative humidity showed the same pattern but in the opposite direction. Fewer than half of the residents experienced thermal discomfort during …

Making Sense: Envy In Libanius' Declamation 30, Andrew Scholtz

Middle Eastern and Ancient Mediterranean Studies (MEAMS) Faculty Scholarship

Declamation, a genre famous for its sometimes extravagant fictions, has lately been approached as a vehicle for declaimers to reflect on realities familiar to them and their audiences. Reading Libanius' rarely discussed Declamation 30 in just such a self-reflective key, I argue that it explores the mindset of the phthoneros, the "envious man," as a way to make sense of risks posed by unscrupulous rivals. To shed light on this sense-making, I analyze High- and Late-Imperial emotion scripts foregrounding envy’s power to catalyze the formation of dysfunctional networks within and around competitive situations.

Size Discrimination In Goldfish (Carassius Auratus), Johnna Patrick

Theses & ETDs

Quantitative abilities in fish have been previously observed, including in natural behaviors such as shoaling and various laboratory tasks. Two-choice visual discrimination tasks require individuals to differentiate between stimuli, and when conditioned, individuals can demonstrate learning of stimulus value. The concept of understanding ordinal relationships has been reported in goldfish (Carassius auratus) before, although no studies have explicitly tested primarily size discrimination. The current study tested four goldfish on their ability to perceive and swim through large vs. small holes, using an adapted methodology and expansion of similar literature. It also tested what the goldfish were learning during the discrimination …

Comparing Autografts And Bioengineered Skin Equivalents In The Management Of Severe Burns, Madison Hill

The PA Department Journal of Medical Science

INTRODUCTION: Severe burns are associated with high morbidity, mortality, and treatment costs, often requiring surgical intervention to restore the skin barrier and prevent complications like infection and hypothermia. Autologous skin grafting is the current gold standard for burn wound closure but may not be feasible in cases of large TBSA injuries with limited donor sites. Bioengineered skin equivalents, including acellular dermal substitutes and cell-based therapies, offer potential benefits in wound healing and scar quality while reducing donor site morbidity. This review evaluates the effectiveness of autografts compared to bioengineered skin equivalents in severe burn management, with a focus on healing …

Extracorporeal Shockwave Therapy For Plantar Fasciitis Pain Reduction, Nathan J. Lopez

The PA Department Journal of Medical Science

Introduction: Plantar fasciitis (PF), aka plantar heel pain (PHP), is a degenerative and debilitating musculoskeletal condition that is prevalent across various populations. There is some debate concerning the hierarchy of second-line treatment options. The purpose of this article is to compare the efficacy, as it relates to pain reduction, of extracorporeal shockwave therapy (ESWT) and other invasive, non-surgical interventions (injections, dry needling, etc.).

Methods: PubMed was searched using a specific search strategy with key terms "extracorporeal shockwave therapy" and "plantar fasciitis". Operators and filters were then applied to narrow results to 4 relevant and quality articles for review. …

Effects Of Angiotensin-Converting Enzyme Inhibitors And Angiotensin Receptor Blockers On Covid-19 Outcomes In Severely Ill Patients, Madison L. Edwards

The PA Department Journal of Medical Science

Introduction: Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the virus SARS-CoV-2 and can cause debilitating illness in vulnerable patient populations. The purpose of this clinical review is to analyze the effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the clinical course and severity in COVID-19 adult patients.

Methods: PubMed was searched with a specific search strategy using key terms “adult,” “COVID-19,” and “RAAS inhibiting medications.” Specific operators and filters narrowed the results to a total of five relevant, quality articles for review.

Results: Two articles were randomized controlled trials that directly compared the continuation of …

Nova Law Review Full Issue Volume 50, Issue 1

Nova Law Review

No abstract provided.

Annual Town Reports For Danville, New Hampshire For The Fiscal Year Ending December 31, 2025, Danville Town Representatives

Danville, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Town Of Raymond, New Hampshire 2025 Annual Report, Raymond Town Representatives

Raymond, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

2025 Annual Town Report And 2026 Town Warrant & Budget, Auburn, New Hampshire, Auburn Town Representatives

Auburn, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Brambles: Place-Based Learning Plan For The Msum Regional Science Center, Drew Vogt

OER Materials

The goal of this assignment was to design an immersive, place-based learning experience that helps preservice teachers engage with their region’s environment of the MSUM Regional Science Center. This lesson uses inquiry-based learning through exploration of bramble plants. Students' activity engages in their learning through hands-on exploration, observation, and curiosity. Students observe the structure and function of bramble plants and their relationship with the surrounding environment. This lesson encourages curiosity and critical thinking skills to drive learning to better understand how plants interact with their environment.

2025 Annual Report Swanzey, New Hampshire, Swanzey Town Representatives

Swanzey, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Universal Sound Separation: Distance-Aware Mixture Simulation, Co-Occurrence Conditioning, And Chain-Of-Inference, Wonjun Park

Computer Science and Engineering Theses - Archive

Universal Sound Separation (USS) -- the task of disentangling arbitrary sound sources from a single-channel acoustic mixture -- remains an open challenge due to the ill-posed nature of the problem and the distributional gap between synthetic training data and real-world recordings. This thesis addresses three distinct bottlenecks in the USS pipeline: training data realism, inference strategy, and conditioning richness. We first present two knowledge-guided approaches to sound source separation. The first is a distance-aware mixing strategy that leverages Large Language Models (LLMs) to assign plausible loudness relationships between audio sources during training data synthesis. By querying an LLM about the …

Enjoying The Golden Screen Of Asian American Representation In A Colorblind Era: Neoliberalism, Narrative, And Negotiation, Jered Mabaquiao

English Dissertations - Archive

This dissertation contributes to Asian American studies, Cinema and Media Studies, and Critical Theory by interrogating how contemporary Asian American representation is shaped by the intertwined pressures of racial politics, neoliberal market demands, and psychic life. Working across race studies, media studies, psychoanalysis, and phenomenological questions of ontology and being, the project argues that Asian American film and television cannot only be understood  through the language of popular culture representation, narrative progress, media visibility, or political inclusion. Instead, I combine such angles to examine how popular culture media participates in the contradictory production of Asian American subjectivity as culturally present …

Untangling Ai Openness, Parth Nobel, Alan Z. Rozenshtein, Chinmayi Sharma

Faculty Scholarship

The debate over AI openness—whether to make components of an artificial intelligence system available for public inspection and modification—forces policymakers to balance innovation, democratized access, safety and national security. By inviting startups and researchers into the fold, it enables independent oversight and inclusive collaboration. But technology giants can also use it to entrench their own power, while adversaries can use it to shortcut years and billions of dollars in building systems, like China’s Deepseek-R1, that rival our own. How we govern AI openness today will shape the future of AI and America’s role in it.   Policymakers and scholars grasp the …

Implementing An Anxiety Management Bundle In Long-Term Nursing Facilities, Sundan G. Bryson

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

There is currently a gap in accurate screening and treatment of anxiety in Long-Term Care (LTC) nursing facilities. The question for this quality improvement project was: Will implementing interventions for long-term care residents aged 65 and older improve anxiety screening, non-pharmacological interventions, and mental health referrals by 10% compared to current practices? Interventions to enhance anxiety screening included the Geriatric Anxiety Scale-Long Term Care (GAS-LTC) tool to assess and score anxiety. In addition, a Non-Pharmacological Intervention (Non-PI) tool was created to evaluate interventions performed by facility staff. Referrals to the mental health care provider were submitted if a resident scored …