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2026

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The Corpus Juris Of (Alaska Native) Inherent Tribal Sovereignty, Nazune Menka Jan 2026

The Corpus Juris Of (Alaska Native) Inherent Tribal Sovereignty, Nazune Menka

Alaska Law Review

The inherent Tribal sovereignty of Native nations predates the formation of the United States and is reflected in the constitutional vision of tripartite sovereignty. Yet their sovereignty is oft diminished explicitly by federal law or implicitly by federal courts. This implicit divestiture is often the result of the federal judiciary’s inconsistent interpretations of Indigenous Peoples law. This Article argues that a more principled and coherent approach for federal judges would be to consistently make use of the corpus juris, or whole body of law, including the in pari materia or affiliated statutes canon. The Article posits that the corpus juris …


Anchoring Deference: The Chevron Doctrine, Loper Bright, And Alaska Administrative Law, Jon W. Katchen, Will R. Crowther Jan 2026

Anchoring Deference: The Chevron Doctrine, Loper Bright, And Alaska Administrative Law, Jon W. Katchen, Will R. Crowther

Alaska Law Review

After statehood, the Alaska Supreme Court operated on a blank legal slate. No Alaska precedent, for example, addressed the fundamental question of when courts should defer to an agency’s statutory interpretation. In addressing this issue, the Alaska Supreme Court largely adopted the framework developed by federal courts in the 1950s and 1960s, prior to the emergence of the Chevron doctrine. The federal case law from this era relied on nebulous standards to guide when an agency’s interpretations were subject to the deferential reasonable basis review. Not surprisingly, by adopting that federal jurisprudence, Alaska precedent suffers from the same shortcomings. And …


Alaska’S Hidden Gems: Advocating For The Protection Of Deep-Sea Corals, Both In The Courtroom And Beyond, Lauren Beizer Jan 2026

Alaska’S Hidden Gems: Advocating For The Protection Of Deep-Sea Corals, Both In The Courtroom And Beyond, Lauren Beizer

Alaska Law Review

Coral reefs are ecologically, financially, and aesthetically one of the world’s greatest resources. Off the coast of Alaska, many unique species of deep-sea cold-water corals exist and provide various public health benefits, contribute vital ecosystem functions to their surrounding environment, and serve as economic tourist attractions. Alaska’s coral reefs are exceedingly valuable to the Earth due to their overall ecological value. However, these unique coral species significantly lack state and federal protections, which have recently been under consideration in several lawsuits at the federal level. American Oceans Campaign v. Daley and Oceana, Inc. v. National Marine Fisheries Service et al., …


Sullivan County Advisory Council January 2026 Meeting Minutes, Extension Jan 2026

Sullivan County Advisory Council January 2026 Meeting Minutes, Extension

Advisory Council

No abstract provided.


Investigating Host Factors In Coronavirus Assembly And Egress, Surovi Binte Sharmin Mohona Jan 2026

Investigating Host Factors In Coronavirus Assembly And Egress, Surovi Binte Sharmin Mohona

Dissertations

Coronavirus (CoV) structural proteins congregate at the ER-Golgi intermediate compartments (ERGIC) prior to virus budding into the organelle lumen. Subsequent trafficking and fusion of virus-containing, ERGIC-derived vesicles then release nascent viruses from infected cells. Our findings in this dissertation illuminate mechanisms by which CoV structural proteins coalesce at the virus assembly and budding sites. The cytoplasmic tails of all CoV spike (S) glycoproteins contain variants of a consensus KxKxx coatomer-binding motif. Host coatomer complexes facilitate retrograde trafficking of client cargo proteins via recognition of such motifs. Utilizing reverse genetics methodologies, we introduced variations in the S coatomer motif in a …


Insights On Global Rangeland Ecosystem Services Shaped By Grazing And Fertilization, Laura Yahdjian, Sofía Campana, Pedro M. Tognetti, Juan Alberti, Pamela Graff, Cecilia Molina, Elizabeth T. Borer, Eric W. Seabloom, Suzanne M. Prober, Andrew S. Macdougall, Anita C. Risch, Jodi N. Price, Sally A. Power, Isabel C. Barrio, Erika Hersch-Green, Philip A. Fay, Sumanta Bagchi, Jonathan D. Bakker, Dana Blumenthal, Elizabeth H. Boughton, Cynthia S. Brown, Miguel N. Bugalho, Marc Cadotte, Maria C. Caldeira, Jane A. Catford, Clinton Carbutt, Qingqing Chen, Scott L. Collins, Thomas W. Crowther, Carla D’Antonio, Christopher R. Dickman Jan 2026

Insights On Global Rangeland Ecosystem Services Shaped By Grazing And Fertilization, Laura Yahdjian, Sofía Campana, Pedro M. Tognetti, Juan Alberti, Pamela Graff, Cecilia Molina, Elizabeth T. Borer, Eric W. Seabloom, Suzanne M. Prober, Andrew S. Macdougall, Anita C. Risch, Jodi N. Price, Sally A. Power, Isabel C. Barrio, Erika Hersch-Green, Philip A. Fay, Sumanta Bagchi, Jonathan D. Bakker, Dana Blumenthal, Elizabeth H. Boughton, Cynthia S. Brown, Miguel N. Bugalho, Marc Cadotte, Maria C. Caldeira, Jane A. Catford, Clinton Carbutt, Qingqing Chen, Scott L. Collins, Thomas W. Crowther, Carla D’Antonio, Christopher R. Dickman

Michigan Tech Publications

Rangelands are crucial to human well-being, but their ability to provide ecosystem services is threatened. We (1) quantified key ecosystem services provided by rangelands, (2) assessed short- and long-term impacts of fertilization (nutrient addition) and the exclusion of large grazing herbivores with fences (herbivore exclusion) on services, and (3) identified synergies and trade-offs among services. We measured indicators of ecosystem services and plant diversity at 79 sites across six continents in the global Nutrient Network. Short-term herbivore exclusion increased forage quantity and soil fertility, but longer-term herbivore exclusion decreased both along with plant richness and pollination. Nutrient addition improved forage …


Ai-Assisted Tailored Intervention For Nurse Burnout: A Three-Group Randomized Controlled Trial, Gumhee Baek, Chiyoung Cha Jan 2026

Ai-Assisted Tailored Intervention For Nurse Burnout: A Three-Group Randomized Controlled Trial, Gumhee Baek, Chiyoung Cha

Individual Articles

Background: High-stress environments, heavy workloads, and the emotional demands of patient care, which are common challenges faced by nurses, are factors that can lead to burnout. Shift work can make traditional burnout interventions costly and difficult to implement. Artificial intelligence (AI) could offer solutions that are less constrained by time, resources, and labor.

Aim: To investigate the effectiveness of an AI-assisted intervention in reducing nurse burnout.

Methods: A single-blind, three-group, randomized controlled trial of 120 nurses (40 per group) was conducted from June 2023 to July 2023. The AI-assisted tailored intervention included two 2-week programs, delivering one of four programs …


Understanding Higher-Order Motion Terms In Image Sequences, Fisseha Admasu Ferede Jan 2026

Understanding Higher-Order Motion Terms In Image Sequences, Fisseha Admasu Ferede

Electronic Theses and Dissertations Archive

This dissertation presents a comprehensive framework for learning accurate, and physically meaningful representation of motion from image sequences. The central theme of this work lies in advancing optical flow estimation from discrete-time two-frame formulation toward a continuous time multi-frame model capable of learning higher-order motion terms and dynamics, with wide ranging applications including developing structural disease biomarkers from medical images. We first develop SSTM (Spatiotemporal Recurrent Transformer for Multi-Frame Optical Flow Estimation), a deep learning model that leverages a sequence of multi-frames to infer accurate optical flow by learning temporal dependencies across successive motion cues. The architecture integrates recurrent 3D …


Can I Freeze-Dry That? A Practical Guide To Safe And Effective Freeze-Drying, Victoria Carlile, Morgan Wayment, Jose Brandao Jan 2026

Can I Freeze-Dry That? A Practical Guide To Safe And Effective Freeze-Drying, Victoria Carlile, Morgan Wayment, Jose Brandao

All Current Publications

Freeze-drying can preserve most everyday foods, but not all foods work well. Whether you are preparing for a long trip or are interested in long-term storage, it is important to know which food can be freeze-dried safely and which ones should not be attempted. This knowledge helps ensure food safety, quality, and success. This fact sheet provides information on how freeze-drying works, the risks involved, and which foods can be more challenging to freeze-dry.


A Chemogenetic Approach For Temporal And Cell-Specific Activation Of Endogenous Gpcrs In Vivo, Gwendolyn Shingles, Qianqian Pang, Jian Weng, Ryan Singer, Waleed Babar, Jiaqi Shen, Luis Vazquez-Rivera, Yao Chen, Peng Li, Wenjing Wang Jan 2026

A Chemogenetic Approach For Temporal And Cell-Specific Activation Of Endogenous Gpcrs In Vivo, Gwendolyn Shingles, Qianqian Pang, Jian Weng, Ryan Singer, Waleed Babar, Jiaqi Shen, Luis Vazquez-Rivera, Yao Chen, Peng Li, Wenjing Wang

2020-Current year OA Pubs

Cell-specific regulation of endogenous G protein-coupled receptors (GPCRs) is crucial for understanding their roles in physiological processes. We present chemogenetic tools using shield-1-dependent irreversible protein switches to regulate peptide agonist activity. To demonstrate this platform, we engineered chemogenetically regulated pituitary adenylate cyclase activating polypeptide (cPACAP), which exhibited >15-fold chemical-dependent regulation of endogenous receptor activity. In vivo application of cPACAP allowed neuronal activation via the endogenous receptor for PACAP, engaging neural circuits that control respiratory and feeding behaviors. By integrating cPACAP with transgenic mice, we selectively activated endogenous PACAP receptor signaling in hypocretin-expressing neurons of the lateral hypothalamic area (LHA), revealing …


The Coalition For Fairness In Soho And Noho, Inc. V. City Of New York Jan 2026

The Coalition For Fairness In Soho And Noho, Inc. V. City Of New York

All Decisions

The Court of Appeals reversed the Appellate Division, upholding the City's 2021 rezoning plan for SoHo/NoHo artist lofts. The plan imposed a one-time fee on landlords for converting Joint Living-Work Quarters for Artists (JLWQA) units to unrestricted residential use. The court held that this fee does not constitute a compensable taking under the Fifth Amendment's Takings Clause. It reasoned that landlords lack a compensable property interest in converting their units to a new, more valuable use, as the fee does not burden their existing property rights or coerce them into relinquishing an interest that the government would otherwise have to …


Differential Virulence And Immune Recognition Of Klebsiella Pneumoniae O-Antigen Subtypes O2Α And O2Β, Paeton L Wantuch, Lloyd S Robinson, Cory J Knoot, Christian M Harding, David A Rosen Jan 2026

Differential Virulence And Immune Recognition Of Klebsiella Pneumoniae O-Antigen Subtypes O2Α And O2Β, Paeton L Wantuch, Lloyd S Robinson, Cory J Knoot, Christian M Harding, David A Rosen

2020-Current year OA Pubs

No abstract provided.


Induction Of Moderate Dna Damage Enhances Megakaryopoiesis And Platelet Production, Virginia Camacho, Luis Francisco Zirnberger Batista, Et Al. Jan 2026

Induction Of Moderate Dna Damage Enhances Megakaryopoiesis And Platelet Production, Virginia Camacho, Luis Francisco Zirnberger Batista, Et Al.

2020-Current year OA Pubs

Megakaryocytes (MKs) are large, hematopoietic cells with a polyploid, multilobulated nucleus. Although DNA replication in MKs (endomitosis) is well studied, limited investigations have examined the impact of DNA instability on megakaryopoiesis. Poly-adenosine diphosphate (ADP) ribose polymerase (PARP) inhibitors are chemotherapeutics that result in accumulation of DNA damage and are commonly associated with thrombocytopenia, presumably mediated through platelet progenitors, MKs. To explore PARP inhibitor-induced thrombocytopenia, we treated mice with the PARP inhibitor niraparib. Although high-dose niraparib treatment led to thrombocytopenia, consistent with clinical observations, lower-dose treatment led to a significant increase in bone marrow MKs, MK progenitors (MkPs), and circulating platelets. …


Confluence, Vol. 4, Iss. 2, Full Issue Jan 2026

Confluence, Vol. 4, Iss. 2, Full Issue

The Confluence

No abstract provided.


Lucy Wortham James And The Gospel Of Wealth: A Case Study Of Female Philanthropy In Rural Missouri During The Progressive Era, Jacob F. Rinehart Jan 2026

Lucy Wortham James And The Gospel Of Wealth: A Case Study Of Female Philanthropy In Rural Missouri During The Progressive Era, Jacob F. Rinehart

The Confluence

Various historical scholars have examined the role of Andrew Carnegie's Gospel of Wealth on philanthropic attitudes and endeavors of affluent Americans during the Progressive Era. Modern developments, driven by post-structural feminist theory, have shown that rural-born Missouri women, exemplified by Phoebe Apperson Hearst, acted as complementary equals to Carnegie through their humanitarian efforts by uniquely interpreting and implementing his social doctrines. However, the existing scholarship has focused substantially on coastal developments, neglecting the role of this benevolence in rural Missouri communities. By examining the philanthropic endeavors of Lucy Wortham James, both during her life and post-mortem through her endowment of …


Land Use Zoning: The Answer To Housing Affordability? A Look At Aukland, New Zealand And Minneapolis, Minnesota, Charlsey Kelly Jan 2026

Land Use Zoning: The Answer To Housing Affordability? A Look At Aukland, New Zealand And Minneapolis, Minnesota, Charlsey Kelly

Georgia Journal of International & Comparative Law

For many individuals, purchasing their first home is a monumental step which they look forward to for years. Homes are one of the most valuable assets individuals purchase within their lifetime. In the current housing market, reaching this milestone is becoming more and more difficult for individuals. Adequate and affordable housing is scarce. This is not just an issue plaguing the United States, but it is an issue many metro areas worldwide currently face.


Cultivating Global Citizenship At Home: A Content Analysis Of Collaborative Online International Learning (Coil), Allison Freed, Evan W. Faidley, Valerie G. Couture, K. Adele Okoli, Leticia De La Garza, Adriian Gardner, Crystal Harris, Leah Horton, Brittany N. Saviers, Sunjung Kim Thao, Amber Wilson Jan 2026

Cultivating Global Citizenship At Home: A Content Analysis Of Collaborative Online International Learning (Coil), Allison Freed, Evan W. Faidley, Valerie G. Couture, K. Adele Okoli, Leticia De La Garza, Adriian Gardner, Crystal Harris, Leah Horton, Brittany N. Saviers, Sunjung Kim Thao, Amber Wilson

International Journal of Transformative Teaching and Learning in Higher Education

This study presents a content analysis of scholarly works on collaborative online international learning (COIL) published between 2015 and 2023. Conducted by an interdisciplinary faculty group, the research explores how COIL literature frames student learning outcomes within internationalization-at-home efforts. Findings reveal that COIL most frequently supports assignments/projects, as well as intercultural communication and global competence, particularly at the undergraduate level. The analysis highlights COIL’s potential to democratize global learning by addressing access barriers for both students and faculty. The study calls for expanded research on the long-term impacts of COIL, inclusive pedagogies, and cross-institutional collaborations to advance global citizenship in …


The Quatrain - Volume 1 Jan 2026

The Quatrain - Volume 1

The Quatrain

The Quatrain is managed by students at Louisiana Tech University and advised by faculty from the College of Liberal Arts. The journal is housed in George T. Madison Hall, where undergraduates collect, assess, and edit submissions from student writers and artists.

The Quatrain is a print and electronic project for people who value quality undergraduate writing and art. Full-dress researched, academic essays and scholarly explorations; photography; life-writing; sculpture; cultural criticism; work that has a reflective, autobiographical style; and creative writing in all its forms: We simply seek to display samples of the interesting, original, and quality work being produced by …


The Quatrain - Volume 3 Jan 2026

The Quatrain - Volume 3

The Quatrain

The Quatrain is managed by students at Louisiana Tech University and advised by faculty from the College of Liberal Arts. The journal is housed in George T. Madison Hall, where undergraduates collect, assess, and edit submissions from student writers and artists.

The Quatrain is a print and electronic project for people who value quality undergraduate writing and art. Full-dress researched, academic essays and scholarly explorations; photography; life-writing; sculpture; cultural criticism; work that has a reflective, autobiographical style; and creative writing in all its forms: We simply seek to display samples of the interesting, original, and quality work being produced by …


The Quatrain - Volume 6 Jan 2026

The Quatrain - Volume 6

The Quatrain

The Quatrain is managed by students at Louisiana Tech University and advised by faculty from the College of Liberal Arts. The journal is housed in George T. Madison Hall, where undergraduates collect, assess, and edit submissions from student writers and artists.

The Quatrain is a print and electronic project for people who value quality undergraduate writing and art. Full-dress researched, academic essays and scholarly explorations; photography; life-writing; sculpture; cultural criticism; work that has a reflective, autobiographical style; and creative writing in all its forms: We simply seek to display samples of the interesting, original, and quality work being produced by …


The Quatrain - Volume 8 Jan 2026

The Quatrain - Volume 8

The Quatrain

The Quatrain is managed by students at Louisiana Tech University and advised by faculty from the College of Liberal Arts. The journal is housed in George T. Madison Hall, where undergraduates collect, assess, and edit submissions from student writers and artists.

The Quatrain is a print and electronic project for people who value quality undergraduate writing and art. Full-dress researched, academic essays and scholarly explorations; photography; life-writing; sculpture; cultural criticism; work that has a reflective, autobiographical style; and creative writing in all its forms: We simply seek to display samples of the interesting, original, and quality work being produced by …


Exploring Chinese Elements In J.D. Salinger’S Works: A Response To Mccarthyism In The Early Cold War Era, Yixin Lu Jan 2026

Exploring Chinese Elements In J.D. Salinger’S Works: A Response To Mccarthyism In The Early Cold War Era, Yixin Lu

CLCWeb: Comparative Literature and Culture

Since the publication of “The Laughing Man” in 1949, various ideas about “China” have emerged in J. D. Salinger’s famously obscure works. This article aims to argue that Salinger’s incorporation of elements related to China and ancient Chinese philosophy in his works illustrates an artistic response to American anxieties during the McCarthy Era. The article uses “The Laughing Man” and “De Daumier-Smith’s Blue Period” as case studies to demonstrate how Salinger’s engagement with “China,” including the concept of indiscrimination from Zen Buddhist ideas, as well as notions of naturalness and non-action from Taoist ideas, develops not only a mystical writing …


Cyborg Feminism And Toxic Colonialism In Chen Qiufan’S Waste Tide, Yuan Yuan Jan 2026

Cyborg Feminism And Toxic Colonialism In Chen Qiufan’S Waste Tide, Yuan Yuan

CLCWeb: Comparative Literature and Culture

The article probes into the interrelationships among cyborg technology, sexual violence, and toxic colonialism represented in the Chinese SF novel Waste Tide by Chen Qiufan. It applies methodologies in posthumanism and ecofeminism and situates the text in the Chinese as well as a global context. It intends to provide a non-Western perspective to understand cyborg feminism by associating the Chinese historical reality with trans-species thinking. It argues that the SF author Chen Qiufan is critical about the anthropogenic body modifications which may challenge the process of female resistance and resilience in the face of gender and colonial oppression. By doing …


In Memoriam Gwangju: Transnational Memoryscapes Of Gwangju And Buenos Aires In The Works Of Han Kang And Im Heung-Soon, Heewon Chung Jan 2026

In Memoriam Gwangju: Transnational Memoryscapes Of Gwangju And Buenos Aires In The Works Of Han Kang And Im Heung-Soon, Heewon Chung

CLCWeb: Comparative Literature and Culture

Currently acclaimed as the first Asian female author who won the Nobel Prize in literature, Korean writer Han Kang has persistently struggled with memoryscapes and traumascapes. Han’s collection of poems Winter Beyond the Mirror delineates the poetic “I”’s experiences of visiting Argentina and describes how she senses the interconnectedness between Gwangju and Buenos Aires. Korean artist-filmmaker Im Heung-soon’s recent film Good Light, Good Air addresses the same issue, and actually Im and Han have shared a mutual concern about it since Han’s novel Human Acts. This essay defines Winter Beyond the Mirror and Good Light, Good Air, coupled …


Daoist Philosophy And Stephen Mitchell’S The Frog Prince: A Fairy Tale For Consenting Adults, Yunfei Yu, Senlin Yu Jan 2026

Daoist Philosophy And Stephen Mitchell’S The Frog Prince: A Fairy Tale For Consenting Adults, Yunfei Yu, Senlin Yu

CLCWeb: Comparative Literature and Culture

In 1999, Stephen Mitchell published The Frog Prince: A Fairy Tale for Consenting Adults, in which he added “a good deal of background materials” and “a certain number of necessary explanations” to the “six-and-a-half-minute” world-famous Grimms’ fairy tale The Frog Prince, making it a psychological and philosophical novella. This paper illustrates how Daoist philosophy is entailed in Stephen Mitchell’s Frog Prince by analyzing the protagonists’ practice of Daoist philosophy: the Princess’s pursuit of a Daoist natural, simple and carefree life; the Frog’s transformation from an ugly frog to a handsome prince by practicing meditation; and the King’s love …


Representation Of Gender Online: The Case Of Moroccan Female Content Creators On Youtube, Basma Kaissy Jan 2026

Representation Of Gender Online: The Case Of Moroccan Female Content Creators On Youtube, Basma Kaissy

Faits de Langue et Société (FLS)

Social media has revolutionised the way we communicate. On YouTube, Moroccan female creators negotiate their visibility and social status. My thesis examines their uses and discourses to better understand online gender dynamics, combining quantitative analysis and nethnography, enriched by a semiopragmatic reading of signs and their effects. From a reflexive perspective, my experience as a woman in the digital world becomes both an analytical asset and a limitation, requiring constant vigilance in the face of possible biases.


Social Science Methodologies Focusing On Women's Emancipation Through Religion Feedback On The Second Rima Doctoral Training Programme In Morocco, Fabienne Samson, Kae Amo, Aïcha Barkaoui, Nadège Chabloz, Anouk Cohen, Marie Nathalie Leblanc, Saliou Ngom Jan 2026

Social Science Methodologies Focusing On Women's Emancipation Through Religion Feedback On The Second Rima Doctoral Training Programme In Morocco, Fabienne Samson, Kae Amo, Aïcha Barkaoui, Nadège Chabloz, Anouk Cohen, Marie Nathalie Leblanc, Saliou Ngom

Faits de Langue et Société (FLS)

This article introduces the special issue, based on presentations by doctoral students who participated in a training school on social science methodologies in autumn 2024. The school took place in Morocco (Casablanca, Rabat and Mohammedia), in partnership with Hassan II University and the Jacques Berque Centre, and was organised as part of the ANR RIMA programme on women's empowerment through religion. This introduction presents the RIMA programme, the activities of the training school, and the various articles written by the students, in order to understand how they respond to the teachings on the themes of gender, inequalities and religiosity, with …


Direct Effects Of Capsaicin On Voltage-Dependent Calcium Channels Of Mammalian Skeletal Muscle, Dmytro Isaev, Tatiana Prytkova, Badarunnisa Mohamed, Mohamed Omar Mahgoub, Keun-Hang Susan Yang, Murat Oz Jan 2026

Direct Effects Of Capsaicin On Voltage-Dependent Calcium Channels Of Mammalian Skeletal Muscle, Dmytro Isaev, Tatiana Prytkova, Badarunnisa Mohamed, Mohamed Omar Mahgoub, Keun-Hang Susan Yang, Murat Oz

Pharmacy Faculty Articles and Research

Capsaicin, a naturally occurring polyphenol, is known to affect energy expenditure and muscle fatigue and modulate contractions in skeletal muscle. The L-type Ca2+ channels are known to be an important ion channel involved in the various muscle functions and the effect of capsaicin on the skeletal L-type Ca2+ channels is currently unknown. In this study, the effects of capsaicin and capsaicin analogs on depolarization-induced Ca2+ effluxes through L-type Ca2+ channels in transverse tubule membranes from rabbit skeletal muscle and L-type Ca2+ currents recorded using the whole-cell patch clamp technique in rat myotubes were examined. Capsaicin, …


High-Dose Oral Pyrophosphate Inhibits Connective Tissue Calcification In Abcc6 Null Mice But May Affect Bone Structure, Ibtesam Rajpar, Nicholas Yancy, Jacob Beiriger, Christina Shao, Syed Naqvi, Deana Mancuso, Fatemeh Niaziorimi, Ryan E Tomlinson, Koen Van De Wetering Jan 2026

High-Dose Oral Pyrophosphate Inhibits Connective Tissue Calcification In Abcc6 Null Mice But May Affect Bone Structure, Ibtesam Rajpar, Nicholas Yancy, Jacob Beiriger, Christina Shao, Syed Naqvi, Deana Mancuso, Fatemeh Niaziorimi, Ryan E Tomlinson, Koen Van De Wetering

Department of Orthopaedic Surgery Faculty Papers

Pseudoxanthoma elasticum (PXE) is a rare inherited disorder marked by abnormal calcium phosphate deposition in soft connective tissues, particularly the skin, arteries, and eyes. It is caused by inactivating mutations in the ABCC6 gene, which encodes a hepatic efflux transporter. Loss of ABCC6 function leads to reduced plasma levels of pyrophosphate (PPi), a key inhibitor of calcification, thereby promoting ectopic mineralization. Oral PPi therapy has emerged as a potential treatment, but its effectiveness is uncertain. Most ingested PPi is hydrolyzed in the gut to inorganic phosphate, which may worsen calcification. Moreover, its impact on mineralized tissues remains largely unexplored. Abcc6−/− …


Global Insight 2026, Masey Smith, Chance Carden, Hayley Pounds Jan 2026

Global Insight 2026, Masey Smith, Chance Carden, Hayley Pounds

Books

Global Insight 2026 is the annual publication of the International Institute at Mississippi State University, documenting the university’s global engagement across education, research, service, and institutional partnerships. This issue highlights Mississippi State University’s international impact through faculty‑led study abroad programs, international research and development initiatives, global fellowships, and comprehensive international student support services. Featured content includes narrative case studies of student and faculty experiences abroad, data‑driven insights into study abroad participation and international enrollment trends, and in‑depth examinations of international research collaborations spanning Africa, Latin America, Europe, and Asia. The magazine also showcases the work of the English Language Institute …