Watchpeopledie . Tv, Noah Lebien

Theses and Dissertations

The thesis piece is a performance called watchpeopledie.tv performed four times at the Anderson Gallery in the Hidden Galleries. There are two rooms in the gallery. The first room is where the audience enters. There is a line on the floor marking that the audience is not to move further into the first room or into the second room. The audio consists of verbatim comments sourced from videos of violence against trans people from the website watchpeopledie.tv, a website in which users post real videos of shootings, suicides, car accidents, etc. The main text, which is my thesis writing below, …

Hafnium Oxide-Based Nanoheterostructures For Catalytic Radiosensitization And Enhanced X-Ray Radiotherapy, Marlen Dariela Calix Quezada

Theses and Dissertations

Orthovoltage X-ray beams are attractive for surface and intra-operative radiotherapy. Yet, their clinical utility is constrained by rapid attenuation and the limited dose that can be delivered without harming healthy tissue. High-Z hafnium oxide (HfO₂) nanoparticles can boost local energy deposition through the photoelectric effect, while catalytic surface defects accelerate water radiolysis. Harnessing both mechanisms in a single nano-heterostructure could enable potent radiosensitization at diagnostic-range energies.

This thesis develops and evaluates HfO₂-based nanoheterostructures, both bare and Au-decorated, as catalytic radiosensitizers.

Two types of HfO₂ were evaluated, one was synthesized following a specific route and the …

Wander, Wonder: Beyond The Window, Se Young Lee

Theses and Dissertations

This thesis explores how small, site-specific interventions can reframe everyday spaces through acts of observation, walking, and placement. In response to the increasing detachment from physical environments caused by digitized, image-saturated culture, this research asks how gentle gestures might restore presence and embodied perception in overlooked urban sites.

Drawing on the notion of the flâneur and grounded in theories by Peter Zumthor, Rebecca Solnit, and others, walking is employed as a form of spatial inquiry—a way of thinking through movement, of seeing through slowness. Along a recurring route between home and studio, three underappreciated sites were identified and engaged through …

Targeting The Achilles’ Heel Of Lung Cancer Induced By Oncogenic P53, Brandon G. Velasco

Theses and Dissertations

Mutations of the tumor suppressor gene, TP53, are the most prevalent oncogenic mutations in lung cancer, occurring in up to 70% of human non-small cell lung cancer (NSCLC). The majority of mutations in p53 are missense mutations that cause not only a loss of tumor suppressor function, but also gain of oncogenic functions, like tumorigenicity, immune suppression, and chemoresistance. Previous studies have shown that the depletion of gain-of-function (GOF) p53 or disruption of its ability to transactivate the expression of genes related to oncogenesis eliminates its tumorigenic properties indicating a dependency of human lung cancer cells expressing GOF p53 …

Enhancing Clinical Trial Matching In Molecular Diagnostics: Using Natural Language Processing And Clustering Approaches In Hematological Malignancies, Gillian Fanning

Theses and Dissertations

Clinical trial matching is a critical component of personalized medicine, particularly in the management of hematologic malignancies. At Virginia Commonwealth University (VCU) Health, the Molecular Diagnostics (MDX) Lab produces somatic variant reports and recommends clinical trials based on the presence of clinically significant mutations. However, the current manual trial recommendation process is time-intensive and lacks scalability.

This study introduces a computational framework to streamline and standardize clinical trial matching using natural language processing (NLP) and unsupervised clustering. Trial brief descriptions were analyzed to extract frequent terms, and trials were grouped based on term similarity using joint dimensionality reduction and clustering. …

Developing Bioinformatics Expertise Through The Annotation Of The Gut Microbiome Of Odontotaenius Disjunctus, Keidra E. Carter

Theses and Dissertations

Next-generation sequencing (NGS) technologies have revolutionized biological research by generating unprecedented volumes of genomic data, necessitating advanced bioinformatics tools and specialized expertise to fully interpret complex microbial communities. This study outlines an integrated workflow to characterize the gut microbiome of the wood-feeding beetle Odontotaenius disjunctus. Prokka is employed for functional annotation to identify protein-coding genes and other genomic features, while Kaiju is used for taxonomic classification. DIAMOND is then applied to locate and validate the taxonomic assignments generated by Kaiju by aligning sequences within the contigs to a comprehensive protein database, proGenomes. Functional analysis revealed that the contigs encode proteins …

Understanding The Experiences Of People Of Color Who Engage In Psychedelic Use, Amber B. Livingston

Theses and Dissertations

There is a growing body of research that supports the potential of psychedelic substances being used to support individuals with alleviating mental health symptoms such as depression, anxiety, and existential distress. Though it has been labeled that Western society is within a psychedelic renaissance, it should also be noted that many indigenous cultures have utilized plant-based medicines as a form of healing and connection. Despite the ever increasing amount of studies being conducted, a consistent deficit is the lack of representation of non-White individuals in research samples. Utilizing the theoretical framework of set and setting, the present study aims to …

Radical Hope Amid Generational Oppression And Puerto Rican Well-Being, Natalia Gomez Giuliani

Theses and Dissertations

Oppressive systems (e.g., colonialism, racism, capitalism) create a disparate distribution of power that, through various mechanisms, negatively impacts the health and well-being of members of the oppressed group. Boricuas have experienced over 500 years of oppression, with the island currently maintaining a colonial relationship with the United States. As these adverse effects of oppression are identified, the need for protective factors (e.g., hope) has emerged. This study explored how islander Boricuas practice radical hope, understand their history of oppression and resistance, and how they perceived it to impact their overall well-being. Utilizing a phenomenological qualitative approach, I conducted 15 semi-structured …

Health Equity In Times Of Crisis: The Impact Of Economic And Public Health Shocks On Access To Care Among Women In Zimbabwe And The United States, Vimbainashe Dihwa

Theses and Dissertations

Abstract

This dissertation examines health equity during times of national public health and economic crises by examining access to care among women of reproductive age. Papers 1 and 2 estimate the effects of the 2020 Covid-19 pandemic in the United States (US). Paper 3 examines the potential effects of the 2008 hyperinflation and subsequent economic crisis in Zimbabwe.

Paper 1 assessed the role of health professional shortage areas (HPSAs) in the Covid-19 pandemic-related temporal trends in mental health access among women in the 18 to 44 years age group with self-reported anxiety and/or depression. The findings suggest decreased unmet prescription …

Climate Change-Induced Shifts In Mediterranean Fungal Fruiting Phenology And Productivity, Rachel Demay

Theses and Dissertations

We used a 29-year dataset of mushroom fruiting from the Pinar Grande forest in northern Spain to investigate the effects of climate change on the phenology, productivity, and diversity of mycorrhizal and saprotrophic mushrooms. We investigated the long-term trends in fruiting season length, yield (by count, total weight, and average weight), and genus richness. Additionally, we identified associations between monthly temperature and monthly precipitation with these fungal responses across functional groups: mycorrhizal, saprotrophic, litter-decaying saprotrophic, and wood-decaying saprotrophic mushrooms, and the economically-important edible genera Boletus and Lactarius. We found that autumnal season length in the Pinar Grande has shortened over …

An Exploration Of The Relationship Between School Counselor Access And Latine Students’ College-Going Behaviors, Kristen Tuxbury

Theses and Dissertations

This study examined the relationships between school counselor access and Latine students’ college-going behaviors using data from the High School Longitudinal Study of 2009 (HSLS:09). The study was guided by critical race theory and Yosso’s community cultural wealth model (2005). Binary logistic regression models, Chi-square tests of independence, and descriptive statistics were used to explore the associations between school counselor access, Latine student college-going behaviors, and caregiver expectations. The findings show stronger associations between caregiver expectations and Latine student college-going behaviors than school counselor access. Additionally, findings provide evidence that experiences of oppression are likely barriers to Bachelor’s degree programs …

Integration Of Phenotyping Into A Preliminary Investigation Of Stand-Alone Web-Based Cognitive Behavioral Therapy Among A Non-Treatment Seeking Sample, Anna B. Parlier-Ahmad

Theses and Dissertations

Alcohol use disorder (AUD) is the most common substance use disorder. However, most people with AUD do not receive treatment. Among those who do, it is only moderately effective largely due to the heterogeneity of people with AUD. Many of these individuals, particularly those with mild AUD, can reduce or cease alcohol use without specialized treatment. However, efforts to refer those with more severe AUD to community residential or outpatient programs have been largely unsuccessful, especially among women who often face practical barriers like lack of transportation and childcare. Technology offers innovative opportunities to make treatment more readily accessible to …

Narratives Of Illness Identity Development In Adolescents With Cancer, Rachel Holder

Theses and Dissertations

Introduction: Adolescence is a pivotal developmental stage characterized by the development of independence, autonomy, and identity. A diagnosis of cancer can be disruptive to this process (Grinyer, 2009; Hazen et al., 2008; Neylon et al., 2023). How one incorporates cancer into their identity, or illness identity, has been associated with clinical outcomes, including adherence, life satisfaction, psychosocial functioning, and health-related quality of life and could be a target for supportive interventions aimed at adolescents with cancer (Commissariat et al., 2020; Luyckx et al., 2008, 2018; Meyer & Lamash, 2020; Oris et al., 2016; Raymaekers et al., 2020). Prior literature has …

Rehabilitation In Stroke-Related Flexor Synergy, Shawn J. Dirocco

Theses and Dissertations

Upper extremity abnormal flexor synergy caused by stroke can impair individuals by coupling upper extremity muscles with deltoid activation. Previous studies have shown that reduction in deltoid loading can decrease flexor synergy. Robotic rehabilitation has the ability to allow for reduced deltoid loading while assisting or constraining joints along the arm to increase rehabilitation outcomes. The effects of higher degree of freedom low impedance robotics needs to be tested to learn how various parameters affect flexor synergy in comparison to end point robotics. During the first experiment, we tested 16 chronic stroke patients with flexor synergy problems in 3 tasks. …

Trauma-Informed Beliefs And Our Child Welfare System, Gabriela Ana Aisenberg

Theses and Dissertations

The integration of trauma-informed care (TIC) into behavioral health and child welfare systems has garnered increasing attention, reflecting a growing acknowledgment of the pervasive and multifaceted impacts of trauma on individuals, families, and service delivery structures (Barnett et al., 2019; Bartlett et al., 2018; Bassuk et al., 2017; Substance Abuse and Mental Health Services Administration [SAMHSA], 2014). Legislation such as the Family First Prevention Services Act (FFPSA) has led to increased adoption of trauma-informed practices through increased funding for training and services (Bowen & Murshid, 2016; Brown et al., 2023). Research shows that providers’ understanding and implementation of TIC is …

Intuitive Mixed Reality Interfaces For Creative And Interactive Robotics: Roboart, Magnaforma, And Playmeow, Miles Popielamc

Theses and Dissertations

This thesis details the development and application of intuitive Mixed Reality (MR) interfaces designed to broaden access to robotic control for creative and interactive uses. The central contribution is the RoboART system, a novel MR interface built with the Microsoft HoloLens 2 to program an ABB GoFa collaborative robot for non-expert users, such as artists. The work describes RoboART's application in the Magnaforma project, where it enabled complex artistic expression.

Additionally, the thesis introduces the PlayMeow project, which explores adaptive pet interaction through a laser-guided turret. This system's control strategies were deeply informed by the intuitive paradigms developed for RoboART, …

Optimal Data Splitting Methods, Sujay Mudalgi

Theses and Dissertations

In predictive modeling, effective data splitting is crucial for creating statistically representative training and validation sets. The state-of-the-art data splitting methods are based on minimizing the energy distance between the split subsets. However, there are a number of limitations in the existing methods, which this dissertation aims to address. First, the existing methods were computationally inefficient. Thus, Chapter 2 proposes a method to scale up these approaches for big data. Here, we introduce scalable Twinning (s-Twinning), which significantly improves the execution speed of data splitting without sacrificing accuracy. Second, the existing methods did not consider the predictive relationship in the …

Machine Learning Models Leveraging Patient-Similarity And Clinical Temporality For Disease Prognoses, Ahmad F. Al Musawi

Theses and Dissertations

Electronic Health Records (EHRs) constitute a comprehensive and high-dimensional repository of clinical data, encompassing a wide array of patient-level information such as diagnoses, procedures, medications, laboratory results, and unstructured clinical narratives. These data hold immense potential for advancing predictive modeling in healthcare, including tasks such as disease progression modeling, hospital readmission prediction, and length of stay (LoS) estimation. However, the intrinsic complexity of EHR data—manifested in its heterogeneity, sparsity, and temporal dynamics—poses significant analytical challenges that limit the generalizability and interpretability of conventional machine learning models. Recent methodological advancements in deep learning and graph-based learning, particularly Graph Neural Networks (GNNs), …

Treatment Resistant Obesity Among Midlife Women Receiving Care From A Specialized Weight Management Clinic, Emily C. Stevens

Theses and Dissertations

Background: Obesity is a complex chronic disease that conveys significant health risk. Women with obesity are at greater risk for associated conditions including heart disease, hypertension, ischemic stroke, and sex-specific cancers compared to their male counterparts. Midlife may present unique challenges for women as it is during this life phase that they experience an increase in their overall obesity prevalence and severity. Some midlife women experience treatment resistant obesity (TRO), a phenomenon not previously explored in the research literature, conceptualized as failure to achieve clinically meaningful weight loss of ≥ 5% after having received medically specialized obesity care for one …

Visible Modulation Of Epsilon Near Zero Materials, Jonathan M. Weber

Theses and Dissertations

While Epsilon-Near-Zero materials have offered many benefits from their introduction to the field of nonlinear optics, those materials have also narrowed the range of wavelengths often studied. With reliable and proven enhancements to light-matter interaction in the ENZ region, many researchers have had little reason to extend the spectrum measured in experiments. The purpose of this work is to measure the intensity dependent refractive index of Indium Tin Oxide across a broad spectral range, from ultraviolet to near infrared, to improve the understanding of semiconductor nonlinearities far from Lorentz and Drude resonances. Furthermore, the visible region is naturally low-loss in …

Characterization Of Nanoplastic-Induced Exacerbation Of Asthmatic Pathophysiology In A Murine In Vivo Model, Keith Li

Theses and Dissertations

As global plastic production increases, so does the environmental and biological presence of nanoplastics (NPs), raising growing concerns about their potential impact on human health. These particles have been detected in various organs, including the lungs, yet their role in respiratory inflammation remains largely unexplored. Emerging evidence suggests that NP exposure may influence immune responses in the lungs, particularly in individuals with preexisting conditions such as asthma. However, the specific ways in which these particles interact with allergen driven inflammation are still unclear.

In this study, a murine model of allergic airway inflammation was used to investigate how surface modified …

Intervertebral Lateral Bending Moment Differences In The Lumbar Spine Of Baseball Pitchers Across Throwing Velocities, Justin Humenay

Theses and Dissertations

Introduction Baseball pitching imposes substantial mechanical demands on the lumbar spine, a crucial link in the kinetic chain responsible for transferring energy from the lower body to the upper extremity. While increased pitch velocity is associated with greater trunk forces the specific intervertebral loading patterns during high-velocity pitching remain unclear. This study investigates differences in lateral bending moments across lumbar spinal segments between collegiate pitchers throwing at high versus low velocities.

Methods Twenty right-handed collegiate pitchers were divided into two groups: high-velocity (n = 10, 90.3 ± 1.6 mph) and low-velocity (n = 10, 81.6 ± 1.1 mph). Motion capture …

Periodic Trends In The Electronic And Magnetic Structure Of Superatomic 3d Transition Metal Chalcogenide Clusters, Gabriel Bohannon

Theses and Dissertations

We have systematically investigated the electronic structure of octahedral transition metal chalcogenide clusters, TM₆S₈(CO)₆, in which the transition metal atoms are from the 3d series in order to identify if periodic properties emerge. We were motivated by the identification of closed electronic shells with electron counts of 96, 100 and 114 in similar clusters from the 4d and 5d transition metal series. Further motivation was the finding of a dual-shell closing in the Fe₆S₈(CN)₆^5- cluster. This cluster is stabilized with a large spin magnetic moment due to the …

Rare Variant Analysis Of Electronic Health Record-Defined Major Depressive Disorder In The All Of Us Research Program, Stephen Emil Vieno

Theses and Dissertations

The underlying pathogenesis of MDD remains poorly understood, with multiple competing hypotheses regarding its exact etiology. As a heterogeneous disorder with relatively low heritability, large-scale genome-wide association studies of MDD have relied on increasingly large sample sizes to identify common genetic variants associated with the disorder. However, the rare variant genetic architecture of MDD is still largely unknown. The aim of the present analysis was to use the AoU—a United States-based biobank that integrates healthcare records from over 50 healthcare systems and possesses whole genome sequencing data for participants—to perform a gene set–based analysis of MDD. This analysis presented several …

Modeling Vaccination Strategies And Intervention Impacts On Infectious Disease Dynamics, Elizabeth B. Amona

Theses and Dissertations

This dissertation explores how mathematical and statistical modeling can inform vaccination strategies and evaluate the impact of interventions during infectious disease outbreaks. Motivated by the challenges observed during the COVID-19 pandemic, the research integrates compartmental modeling, Bayesian inference, and agent-based simulation to assess policy effectiveness and disease control across varying contexts. The first study develops a SEIRDV model that incorporates government interventions and vaccination rollout to examine COVID-19 dynamics in Qatar. A Bayesian approach is used to estimate parameters and compute time-varying transmission rates. The model captures shifts in transmission following policy changes and quantifies the reduction in deaths attributable …

Exploring Collaboration In Interdisciplinary Ei/Ecse Programs: A Qualitative Study On Service Provider Preparation, Meagan Dayton

Theses and Dissertations

Interdisciplinary preparation is critical for early childhood special education professionals, yet few programs are designed to support such collaboration across disciplines. This study aimed to explore how interdisciplinary EI/ECSE preparation programs support collaboration. The study was guided by the following research questions: (1) How are program components designed to support the development of collaboration skills? (2) What is the student experience of collaboration in the program? (3) What connections exist between program components, student experiences, and the development of collaboration skills? Using a qualitative multiple-case study approach grounded in ecological systems theory, data were collected from program documents and interviews …

Bugs In The Flux: Links Between Arthropod Diversity And Spatial Variation Of Soil Respiration In A Temperate Forest, Erin-Darby H. Mcclain

Theses and Dissertations

Soil respiration (Rs) is the largest terrestrial flux of carbon (C) to the atmosphere, with heterotrophic contributions to Rs varying spatially and temporally. While microbes are the primary and most thoroughly studied source of soil heterotrophic respiration (Rh), contributions from higher trophic organisms, including arthropods, are rarely quantified and poorly understood. Arthropod abundance and diversity correspond with variation in soil microclimate, which is influenced by site factors including canopy structure, site productivity, and disturbance. However, the extent to which these site factors influence arthropod abundance and diversity, and consequently, spatial variation in Rs is not known. The objective of our …

Automated Treatment Planning Framework For Cervical Cancer In Brachytherapy, Suman Gautam

Theses and Dissertations

Brachytherapy (BT) is a critical treatment modality for cervical cancer that delivers ionizing radiation directly to the tumor using intracavitary (IC) and/or interstitial (IS) applicators. In high dose-rate (HDR) BT, a remote afterloader guides the radioactive source to specific dwell positions for defined durations, known as dwell times, allowing for a conformal dose to the tumor while minimizing exposure to surrounding organs at risk (OAR). However, due to the inherent nature of ionizing radiation, some dose to OARs is unavoidable, creating a fundamentally conflicting objective in treatment planning: maximizing tumor coverage while minimizing OAR dose. This characterizes the problem as …

Plasmon-Assisted On-Chip Integration Of Quantum Emitter For Scalable Quantum Networking, Samprity Saha

Theses and Dissertations

In recent decades, quantum theory has sparked a revolutionary outlook on our long-standing perception of information processing and communication technologies. Photon-based quantum systems, relying on single photons governed by quantum mechanics, hold immense promise for quantum networks due to their resilience against decoherence and fast propagation speeds. However, challenges persist in realizing practical quantum networks, including the need for scalable, robust, and cost-effective quantum light. To address these challenges with classical photonic concepts, this thesis focuses on a plasmon-assisted approach for on-chip integration of single-photon sources. The study aims to develop a scalable solution for integrating quantum emitters on-chip, leveraging …

An Adaptive Method For Covariate Balancing In Block Randomized Clinical Trials, Ren Rasnick

Theses and Dissertations

Clinical trials are randomized in part to limit allocation bias, but also to ensure comparability between treatment arms for a baseline variable of concern. Comparable with regard to a baseline variable of concern is necessary for the validity of statistical methods. However, comparability is not guaranteed for trials of any size and is even more likely in trials with < 200 total participants. We propose a new method for adapting the allocation of participants in a sequentially allocated two-armed study with a small sample size to better ensure comparability.

The proposed method calculates the expected final imbalance (lack of comparability) based on the current participant values. Unlike several other methods, our method ensures the final desired sample size for each treatment arm, utilizes the expected final imbalance, increases comparability between …