Digital Commons Network^™

Tumor Microenvironment Immunomodulation By Nanoformulated Tlr 7/8 Agonist And Pi3k Delta Inhibitor Enhances Therapeutic Benefits Of Radiotherapy, Mostafa Yazdimamaghani, Oleg V. Kolupaev, Chaemin Lim, Duhyeong Hwang, Sonia J. Laurie, Charles M. Perou, Alexander V. Kabanov, Jonathan S. Serody

Chemical and Biochemical Engineering Faculty Research & Creative Works

Infiltration of immunosuppressive cells into the breast tumor microenvironment (TME) is associated with suppressed effector T cell (Teff) responses, accelerated tumor growth, and poor clinical outcomes. Previous studies from our group and others identified infiltration of immunosuppressive myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) as critical contributors to immune dysfunction in the orthotopic claudin-low tumor model, limiting the efficacy of adoptive cellular therapy. However, approaches to target these cells in the TME are currently lacking. To overcome this barrier, polymeric micellular nanoparticles (PMNPs) were used for the co-delivery of small molecule drugs activating Toll-like receptors 7 and 8 …

Umfc #132: A Comprehensive Forensic Case Report, Allison Paige Mitchell

Graduate Student Theses, Dissertations, & Professional Papers

This case report of an individual designated as University of Montana Forensic Case 132 (UMFC 132) serves to partially fulfill the requirements for the Master of Arts (MA) degree in Forensic and Biological Anthropology. UMFC 132 is a complete human skeleton, used as part of the teaching collection in the University of Montana Forensic Anthropology Laboratory. The minimum number of individuals (MNI) of UMFC 132 is 1. The analysis of UMFC 132 was conducted according to bioarchaeological and forensic anthropological standards of skeletal assessment. UMFC 132 was estimated to be a mid-adult, between the ages of [30-40 years] of age …

Workable Seams, Jackson Mills Smith

Graduate Student Theses, Dissertations, & Professional Papers

In Jackson Mills Smith’s Workable Seams, readers encounter the stories, landscapes, and lives of rural Knox County, Indiana, from the oscillating vantage of a Hoosier boy raised with a Cajun sensibility. After relocating from Louisiana to the river bottoms of the crossroad state at a young age, the speaker gradually uncovers a local history only previously understood in fragmentary shards and fading glimpses.

Alternating between semi-lyrical embodied experiences and memories, documentary pieces in conversation with the state’s historical archive, and the retelling of exaggerated local yarns, poetry is a means of inquiry in Workable Seams. Topics range from …

Enhanced Biofuel Cells Based On A Hybrid Enzymatic/Bimetallic Composite For Complete Lactate Catalytic Electrooxidation, Jefferson Honorio Franco, João Victor Bonaldo, Shelley D. Minteer, Adalgisa R. De Andrade

Chemistry Faculty Research & Creative Works

We describe complete lactate electrooxidation in an enzymatic biofuel cell that combines the catalytic action of the bimetallic composite Ru@Pt-CNT and the enzyme oxalate oxidase (OxOx). The Ru@Pt-CNT/OxOx hybrid electrode was 2.0-fold more catalytically active than the electrode containing the bimetallic composite only. During chronoamperometric experiments, the hybrid electrode achieved a 35% higher maximum current density (2.65 ± 0.15 mA cm^-2) than the Ru@Pt-CNT electrode. Electrochemical impedance spectroscopy showed that the hybrid electrode had lower charge transfer resistance than the Ru@Pt-CNT electrode, confirming that OxOx had a high affinity for lactate during the bioelectrocatalytic reaction on the electrode …

Fecal Glucocorticoid Metabolite And T3 Profiles Of Orphaned Elephants Differ From Non-Orphaned Elephants In Zambia, Daniella E Chusyd, Janine L Brown, Steve Paris, Nicole Boisseau, Webster Mwaanga, Moses Kasongo, Lisa Olivier, Stephanie L Dickinson, Bailey Ortyl, Tessa Steiniche, Steven N Austad, David B Allison, Michael D Wasserman

Children’s Nutrition Research Center Staff Publications

Background: Elephants provide valuable insight into how early-life adverse events (ELAEs) associate with animal health and welfare because they can live to advanced ages, display extensive cognitive and memory capabilities, and rely heavily on social bonds. Although it is known that African savanna elephants that experienced ELAEs, such as being orphaned due to human activities, have altered behavioral outcomes, little is known regarding the physiological consequences associated with those stressors.

Methods: We compared fecal glucocorticoid (fGCM) and thyroid (fT3) metabolites as well as body condition scores (BCS) in rescued and rehabilitated orphaned (early-dry season: n = 20; late-dry season: n …

Mapping Epidermal And Dermal Cellular Senescence In Human Skin Aging, Grace T Yu, Clarisse Ganier, David B Allison, Tamara Tchkonia, Sundeep Khosla, James L Kirkland, Magnus D Lynch, Saranya P Wyles

Children’s Nutrition Research Center Staff Publications

Single-cell RNA sequencing and spatial transcriptomics enable unprecedented insight into cellular and molecular pathways implicated in human skin aging and regeneration. Senescent cells are individual cells that are irreversibly cell cycle arrested and can accumulate across the human lifespan due to cell-intrinsic and -extrinsic stressors. With an atlas of single-cell RNA-sequencing and spatial transcriptomics, epidermal and dermal senescence and its effects were investigated, with a focus on melanocytes and fibroblasts. Photoaging due to ultraviolet light exposure was associated with higher burdens of senescent cells, a sign of biological aging, compared to chronological aging. A skin-specific cellular senescence gene set, termed …

Separability Doctrine: Perspectives From China, England And The Model Law, Jia Jun Benjamin Goh

Research Collection Yong Pung How School Of Law

In this article, the author compares the application of the separability doctrine in the People's Republic of China, England and Wales, and select Model Law jurisdictions (including Singapore and Hong Kong). This article argues that the proper scope of the doctrine must include situations of both contractual validity and existence are in question. Additionally, the doctrine should apply in finding that the law of the arbitration agreement is different from the law of the main contract. Finally, the doctrine must also serve to protect party autonomy to shield an arbitration agreement from self defeating main agreements.

A Comparative Analysis Of Artificial Intelligence Regulation: Implications For Singapore, Cheng Kit Kit Pang

Research Collection Yong Pung How School Of Law

In relation to artificial intelligence (“AI”) regulation, Singapore presently adopts a wait-and-see approach, refraining from implementing any hard regulation before 2026. This article is directed at making recommendations for Singapore’s future AI hard regulation and conducts a comparative analysis of the hard AI regulation in the EU, the People’s Republic of China (“China”) and South Korea. This article draws lessons specifically from Asian jurisdictions with similar socio-legal and commercial considerations. In particular, China and South Korea are at the forefront, actively pushing for hard regulation. Key takeaways include the potential drivers for a shift towards hard regulation, the scope and …

Machine Learning Modeling For Hydrolysis Recycling Of Pet Waste, Jie Li, Lanjia Pan, Hossein Abedsoltan, Hailong Wang, Taiyang Liu, Xiangzhou Yuan, Yong Sik Ok, Yin Wang

Chemical and Biochemical Engineering Faculty Research & Creative Works

The hydrolysis of polyethylene terephthalate (PET) into terephthalic acid (TPA) can efficiently recycle waste PET, but achieving high conversion efficiency through smart reaction design remains challenging. To develop a robust and accurate machine learning (ML) model for the in-depth understanding and intelligent design of PET hydrolysis, we compiled a new dataset comprising 942 data points and comprehensive information of 44 variables involved in heating type, acid/base catalyst (ABC), organic solvent (OS), co-solvent (CS), phase transfer catalyst (PTC), and operational conditions. The developed Neural Network model demonstrated the best performance in predicting PET conversion, with a testing determination coefficient (R^{2 …}

Cultivating Confidence, Leila Halawi, Mark Miller, Sam Holley

Publications

Artificial intelligence (AI) is pervasive in scholarly publications, internet sites, and public discourse. AI is a term with broad scope that refers to machines that can learn and perform tasks that typically require human intelligence. The specter of AI intruding into many aspects of aviation has raised alarms, concerns, and prodigious misunderstanding of potential and contemplated applications in systems and processes. The EASA AI Roadmap (EASA, 2023 ), a linear projection with three levels EASA, 2023 extending into 2050, places the human-AI teaming period (through 2035) at Level 2. This suggests a ten-year span to develop the interactive issues to …

Embracing Ai In Higher Education: Redefining Teaching And Learning In The Digital Era, Najem Tala, Leila Halawi

Publications

This research explores the transformative potential of Artificial Intelligence (AI) in education, focusing on its ability to address emerging challenges and revolutionize teaching practices. We critically assess the current educational landscape, evaluate AI's role as a catalyst for educational reform, and examine implementation challenges. Our analysis emphasizes the evolving impact of AI on personalized learning, student engagement, and administrative efficiency and contributes to the growing body of literature on educational technology. The discussion highlights both the opportunities and limitations of AI in education, pointing to critical areas that remain underexplored.

Integrating Sustainability Into Aviation Training: Perspectives From Industry Professionals, Eva Maleviti, Sarah Talley

Publications

This paper is part of a broader research project aimed at identifying the most appropriate training materials, formats, and delivery methods for aviation sustainability content for future aviation professionals, starting from the early stages of their training. The current paper presents the data analysis and results of a short online survey targeting aviation professionals. Specifically, it provides preliminary data on sustainability perspectives from global aviation professionals. Through qualitative analysis, the creation of a baseline from a random sample of aviation professionals offers insight into their perspectives and how they could be influenced toward a more sustainable pathway. Additionally, the paper …

A Maintenance Repair And Overhaul Model For Operational Sustainability; Incorporating Processes And Risks., Linn Guinn, Mary M.H. Woody, Eva Maleviti

Publications

Maintenance, Repair, and Overhaul (MRO) companies are integral to the aviation industry, with the core responsibility of ensuring aircraft remain safe and airworthy. Their role is critical in maintaining the industry’s high standards of performance and safety. To remain competitive, MROs must provide a wide range of services—including inspections, periodic checks, engine overhauls, avionics repairs, fuselage and cabin modifications, and interior refurbishments— while consistently meeting regulatory and safety requirements. Beyond technical compliance, MROs must adopt a quality-driven, continuous improvement approach to manage risks effectively. This requires the integration of processes, programs, and systems aligned with international standards to strengthen resilience, …

Implementation Of A Pediatric Skills And Simulation Workshop Among Rural Nurses, Cassandra Grabiel

Doctor of Nursing Practice (DNP) Practice Innovation Projects

No abstract provided.

Impact Of Acuity-Based Assignments On The Satisfaction And Burnout Of Inpatient Rehabilitation Nurses, Madelyn Miller Smith

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Background: With half of healthcare workers reporting burnout, job dissatisfaction and burnout are nursing epidemics. Staffing shortages and heavy workloads are leading dissatisfiers. Acuity-based assignments (ABAs) can predict patient needs and equitably distribute workload among nurses.
Local problem: Nurses of a 21-bed inpatient rehabilitation facility identified burnout related to workload. There was no standard practice for creating assignments, and the existing acuity measure was not rehab-specific.
Methods: An ABA tool was implemented over 12 weeks. Nurse satisfaction and burnout were measured with an abbreviated Copenhagen Burnout Inventory and the Nurse Satisfaction with the Quality of Care Scale, which were administered …

A Mindful Approach To Mitigate Nurse Burnout, Kaysie Engstrom

Doctor of Nursing Practice (DNP) Practice Innovation Projects

No abstract provided.

Minimizing Fasting Requirements To Maximize Patient Satisfaction Prior To A Scheduled Cardiac Catheterization, Kierra Thies

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Background: Patients are often kept NPO (nil per os), or “nothing by mouth,” longer than necessary before cardiac catheterization procedures. Local Problem: Patients scheduled for cardiac catheterization procedures receive instructions to begin fasting at midnight on the day of their procedure regardless of their scheduled procedural start time. This directive results in patient dissatisfaction as patients are fasting longer than current guideline recommendation.
Methods: The facility updated its order set to align with the American Society of Anesthesiologists (ASA) fasting guidelines for scheduled cardiac catheterizations. To evaluate patient satisfaction, a 6-item survey was administered to 169 individuals undergoing cardiac catheterization. …

Implementation Of A Post-Procedure Standardized Order Set, Dylan Waldner

Doctor of Nursing Practice (DNP) Practice Innovation Projects

No abstract provided.

Implementation Of Vibration Anesthesia For Pain Reduction In Clients Undergoing Facial Aesthetic Procedures, Shaylee Dallager

Doctor of Nursing Practice (DNP) Practice Innovation Projects

No abstract provided.

Gratitude Practices For Reducing Burnout In Inpatient Psychiatric Healthcare Workers, Amanda Noonan

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Background: Burnout is a growing problem for healthcare workers and hospital systems. This project explores simple and cost-effective gratitude practices aimed at reducing burnout among mental healthcare workers in a psychiatric hospital.
Methods: Twenty patient care technicians, behavioral health technicians, and nurses from an inpatient psychiatric unit participated in a four-week gratitude intervention. The intrapersonal intervention involved writing weekly gratitude notes to coworkers and putting them on a gratitude wall. The personal intervention included recognizing three things to be grateful for twice weekly in a personal gratitude journal. Participants completed the Copenhagen Burnout Inventory (CBI) and Gratitude Questionnaire (GQ-6) pre- …

Accurate Body Weight Class Prediction From Mirna And Gene Expression In Blood And Saliva Samples, Kimberly Lettner

Master of Science in Forensic Science Directed Research Projects

miRNA interference on protein abundance related to glucose uptake and lipid production has been evaluated in biomedical research and linked to metabolic disorders like severe obesity. The direct regulation of protein abundance caused by miRNAs on a person’s metabolism can lead to an increased weight and overall size. Body size, measured by BMI, provides additional physical descriptions that can be combined with hair color, eye color, age, and skin pigment to aid investigations of unidentified remains or unknown suspects not found in a database. The purpose of this project was to evaluate the miRNA expression of target biomarkers in dried …

Novel Time-Since-Deposition Signatures For Canine Blood; Implications For Animal Cruelty Investigations, Alysia M. Townsley

Master of Science in Forensic Science Directed Research Projects

Dogfighting is a felony in all 50 states and is often tied to other organized crime activities including gambling, narcotics, and weapons trafficking. Because of the clandestine nature of dogfighting crimes, it may be necessary to determine the age of blood samples from suspected events, not just the source. In this study, flow cytometry was used to identify cellular autofluorescence signatures for estimating TSD (time-since-deposition) in canine blood deposits up to 6 months old. To accomplish this, blood was taken from canines of various chronological ages and breeds, then deposited to create TSD samples ranging between 1 day and 180 …

Biodistribution And Method Validation Of Xylazine In A Mouse Model Using Liquid-Chromatography-Quadrupole-Time Of Flight Mass Spectrometry, Julia E. Perschbacher

Master of Science in Forensic Science Directed Research Projects

Xylazine is a nonopioid veterinary sedative and an α2 adrenergic receptor agonist. It emerged in the opioid epidemic as an adulterant of illicit fentanyl. As xylazine becomes more involved in fatal overdoses, it is relevant to elucidate its biodistribution post-exposure due to its exacerbation of adverse events, namely respiratory depression, as xylazine’s contributions to existing adverse effects of synthetic opioids is understudied. A bioanalytical method to quantify xylazine and select metabolites in tissue using LC-QToF was validated and applied to a preclinical mouse model in order to characterize xylazine’s biodistribution in whole blood and six tissues at a dose known …

Qualitative Method Validation Of Acid/Neutral Drugs Carisoprodol, Meprobamate, And Naproxen Using Liquid Chromatography-Tandem Mass Spectrometry, Kate O. Martin

Master of Science in Forensic Science Directed Research Projects

Meprobamate, carisoprodol, and naproxen are acidic/neutral drugs widely prescribed for muscle relaxation and inflammatory conditions, with frequent detection in forensic toxicology casework due to extensive clinical use. A method to qualitatively evaluate these compounds was developed to unify acid/neutral drug screening. This study incorporated blank blood, antemortem blood, postmortem blood, urine, and liver homogenate as representative biological matrices. Method validation was conducted in accordance with ANSI/ASB Standard 036 for Forensic Toxicology, encompassing key parameters including limit of detection (LOD), endogenous interferences, potential interferences, carryover, processed sample stability, and ionization suppression/enhancement. The validation was performed using the internal standards carisoprodol-D7, meprobamate-D7, …

Associations Between Brain White Matter Hyperintensities And Diet Quality In Cognitive Aging: A Cross-Sectional Assessment, Carla V. Urdaneta

Honors Undergraduate Theses

Leukoaraiosis, or White Matter Lesions (WMLs)/White Matter Hyperintensities (WMHs), are often considered markers of aging and neurodegeneration. White matter hyperintensities appear as lighter, hyperintense regions on T2-weighted fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) scans and are physiologically characterized as demyelination and axonal loss reflected as microvascular lesions in cerebral white matter (Marseglia et. al., 2019). These anatomical landmarks are most seen in MRIs of elderly individuals. They can be associated with aging and cognitive decline, including affected frontal lobe function and episodic memory in the form of delayed recall performance and are linked to several cardiovascular risk factors, …

Comparative Semiotic Analysis Of Non-Verbal Communication: Apis Mellifera Waggle Dance And Human Kinesic Signaling Systems, Nishtha Tikalal

Honors Undergraduate Theses

There are many parallels between two seemingly disparate forms of non-verbal communication: the waggle dance of Apis mellifera (honeybees) and human kinesic signaling systems. Through a comparative semiotic analysis, this research aims to conduct a comparative semiotic analysis, investigating structural and functional similarities between these communication methods, challenging anthropocentric assumptions about meaning making in the natural world. This research employs a meta-synthesis approach, drawn from a methodological literature review to examine historical representations of bee-human relationships, semiotics of non-verbal communication, and the specific mechanisms of the waggle dance and human kinesics. This methodology involves systematic categorization and analysis of extracted …

Nursing Simulation For Pediatric Communication: An Integrative Literature Review, Jayla R. Call

Honors Undergraduate Theses

The aim of this thesis is to explore literature focused on enhancing nursing students' communication skills with pediatric patients through simulation. Effective communication is key to building rapport and trust, which are essential for improving patient outcomes. However, nursing students may experience anxiety when interacting with pediatric patients due to limited training in communication techniques. Simulation offers a valuable opportunity for students to practice and refine their skills in a risk-free environment, allowing them to build confidence and competence. An integrative literature review was conducted, utilizing three databases and PRISMA guidelines (Page et al., 2021) to gather relevant studies for …

From Vinyl To Viral: Evaluating The Mere Exposure Effect Through Music And Technological Advancements, Ariana R. Deboo

Honors Undergraduate Theses

The Mere Exposure Effect (MEE) refers to a psychological pattern in which a person develops preference for a stimulus that has been repeatedly presented to them. The present study examined environmental influences of preference through repeated exposure to music. Social media platforms such as TikTok, Reels, and Shorts influence where people listen to music. The fast-paced consumption algorithm for new media is provided by quick, entertaining videos that allow users to scroll past content that does not keep their attention. A total of 406 participants (n=406) were involved in this study. The purpose for this study was to identify how …

Cannabis Use And Functional Independence Among Older Adults: The Health And Retirement Study, Jade Alaine Perry

Honors Undergraduate Theses

As people age, negative cognitive effects become more common, and the likelihood of chronic disease diagnoses increases. Many older adults suffer from one or more chronic health issues that have serious impacts on both their mental and physical health. Chronic pain is also known to increase in prevalence as we age. Opioid use to treat chronic pain among older adults is worrisome due to the likelihood of drug-drug interactions due to polypharmacy and the risk of problematic opioid use that can lead to overdose. Cannabis use both medical and recreational has become more acceptable among the aging adult population in …

The Impact Of Religiosity On Political Knowledge Among Youth Voters, Norah Sackett

Honors Undergraduate Theses

As political engagement trends among young voters have continued to shift in the United States' political atmosphere, understanding the cognitive factors that influence these decisions is becoming increasingly important. Political efficacy, or the feeling that individual political action can impact the political process, impacting their civic duties, has long been regarded as a key determinant of an individual's political engagement. This study investigates how young voters' understanding of prominent political arguments relates to their sense of political efficacy, with a specific lens on individual religiosity.

Through an examination of this relationship between religiosity and overall comprehension of political arguments, this …