Digital Commons Network^™

Exploring Parenting Students’ Experiences With Institutional Support Using The Loss/Momentum Framework, Paula Kwok Jung

LMU Theses and Dissertations

The California Community College system serves as the primary entry point for our marginalized student populations. According to Cruse et al. (2019), approximately 22% of nontraditional students in colleges and community colleges identify as student parents. Student parents are highly motivated to succeed in their academic journey. However, due to various factors including institutional barriers and the lack of support, it was found that only 37% of all parenting students complete a degree or certificate within six years, compared to 60% of non-parenting college students (Reed et al., 2021). Research has shown that institutional actions and support play a crucial …

Integrating Ctdna Analysis And Radiomics For Dynamic Risk Assessment In Localized Lung Cancer, Everett J Moding, Mohammad Shahrokh Esfahani, Cheng Jin, Angela B Hui, Barzin Y Nabet, Yufei Liu, Jacob J Chabon, Michael S Binkley, David M Kurtz, Emily G Hamilton, Aadel A Chaudhuri, Chih Long Liu, Zhe Li, Rene F Bonilla, Alice L Jiang, Brianna C Lau, Pablo Lopez, Jianzhong He, Yawei Qiao, Ting Xu, Luyang Yao, Saumil Gandhi, Zhongxing Liao, Millie Das, Kavitha J Ramchandran, Sukhmani K Padda, Joel W Neal, Heather A Wakelee, Michael F Gensheimer, Billy W Loo, Ruijiang Li, Steven H Lin, Ash A Alizadeh, Maximilian Diehn

Faculty, Staff and Student Publications

The complementarity and clinical utility of combining liquid biopsies and radiomic image analysis has not been demonstrated. Circulating tumor DNA (ctDNA) minimal residual disease after chemoradiotherapy (CRT) for non-small cell lung cancer (NSCLC) is highly prognostic, but on-treatment biomarkers are needed to enable response-adapted therapies. Here, we analyzed 418 patients with NSCLC undergoing CRT to develop and validate a novel dynamic risk model that accurately predicts ultimate progression-free survival during treatment. We optimize tissue-free variant calling from plasma samples to facilitate ctDNA monitoring and demonstrate the importance of accounting for persistent clonal hematopoiesis variants. We show that mid-CRT ctDNA concentration …

Car-Macrophage Cell Therapy: A New Era Of Hope For Pancreatic Cancer, Daoyan Wei, Liang Wang, Yi Liu, Xiangsheng Zuo, Xiling Shen, Robert S Bresalier

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies, characterized by late diagnosis, early metastasis, and resistance to conventional therapies. A major barrier to effective treatment is its desmoplastic and immunosuppressive tumor microenvironment (TME), which restricts T cell infiltration and dampens responses to immune checkpoint inhibitors (ICIs). These features highlight the urgent need for innovative immunotherapeutic strategies capable of overcoming PDAC's immunologic and physical barriers. Chimeric antigen receptor (CAR)-macrophage (CAR-M) therapy has emerged as a promising approach to address these challenges. Unlike CAR-T or CAR-NK cells, CAR-Ms can efficiently infiltrate tumors, remodel the TME, phagocytose tumor cells, and stimulate …

Depletion Of Effector Regulatory T Cells Associates With Major Response To Induction Dual Immune Checkpoint Blockade, Xianli Jiang, Nils-Petter Rudqvist, Bo Jiang, Shengbin Ye, Shan He, Qingnan Liang, Jinzhuang Dou, Michelle D Williams, Joe Dan Dunn, Jason M Johnson, Keiko Akagi, Weihong Xiao, Shaoheng Liang, Satvik Elayavalli, Baohua Sun, Edwin R Parra, Renata Ferrarotto, Adam S Garden, Clifton David Fuller, Jay Reddy, Neil D Gross, Miriam N Lango, Cheuk Hong Leung, Suyu Liu, Diane D Liu, Meng Li, J Jack Lee, Michael A Curran, Jack Phan, Ken Chen, Maura L Gillison

Faculty, Staff and Student Publications

In a phase II trial, patients with local-regionally advanced human papillomavirus-positive oropharyngeal carcinoma (n = 35) received ipilimumab (anti-CTLA4) and nivolumab (anti-PD-1) as induction immunotherapy and concurrently with radiotherapy (NCT03799445). Coprimary endpoints included 6-month complete metabolic response rate (94%) and 2-year progression-free survival (84%). Induction yielded a 46% major histopathologic response rate. Single-cell profiling revealed responders had higher baseline intratumoral CD8+ T cells with a tumor-reactive, tissue-resident memory (TRM) phenotype and a treatment-related decrease in effector regulatory T (eTreg) cells. The eTreg decrease correlated with CD8+ T-cell clonotype transitioning from TRM to effector memory and IFNG+ effector cells. …

Lanthorn, Vol. 60, No. 01, August 4, 2025, Grand Valley State University

Volume 60, August 4, 2025 – April 20, 2026

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Optimization Of Light Spectrum During The Early Grow-Out Of Caribbean Corals, Liam A. Abrams

All HCAS Student Capstones, Theses, and Dissertations

For at least half a century, numerous direct and indirect anthropogenic stressors have led to the decline of coral populations globally. To minimize this decline and preserve genetic diversity, land-based nurseries have been sexually propagating corals to repopulate reefs. While the techniques to induce corals to spawn and rear their larvae are relatively well-established, the grow-out, i.e. rearing from newly settled to a size suitable for outplanting, remains yet to be fully optimized. Specifically, light spectrum, food quantity and quality and algal control require optimization. This study investigated the post-settlement survival and growth of the Caribbean reef building corals Colpophyllia …

Nemvaleukin Alfa Monotherapy In Patients With Advanced Melanoma And Renal Cell Carcinoma: Results From The Phase 1/2 Non-Randomized Artistry-1 Trial, Emiliano Calvo, Valentina Boni, Olivier Dumas, Sang Joon Shin, Seth D Rosen, Arvind Chaudhry, Philip R Debruyne, Xiaomin He, Ulka N Vaishampayan, David F Mcdermott

School of Nursing and Midwifery

BACKGROUND: Despite improved outcomes with immune checkpoint inhibitors (ICIs) and their combinations in advanced solid tumors, a subset of patients remains unresponsive or progresses, highlighting an unmet need for novel treatments with durable benefit. Nemvaleukin alfa (nemvaleukin, ALKS 4230) demonstrated manageable safety and antitumor activity, alone and in combination with pembrolizumab, across heavily pretreated advanced solid tumors in the ARTISTRY-1 study. We report in-depth antitumor activity, safety, pharmacokinetics, and pharmacodynamics of nemvaleukin monotherapy at the recommended phase 2 dose (RP2D) in advanced melanoma and renal cell carcinoma (RCC) cohorts from ARTISTRY-1.

METHODS: ARTISTRY-1 was a three-part (A, B, and C), …

Mechanistic Role Of Heavy Metals In Driving Antimicrobial Resistance: From Rhizosphere To Phyllosphere, Rahul Kumar, Tanja P. Vasić, Sanja P. Živković, Periyasamy Panneerselvam, Gustavo Santoyo, Sergio De Los Santos Villalobos, Adeyemi Nurudeen Olatunbosun, Aditi Pandit, Leonard Koolman, Debasis Mitra, Pankaj Gautam

Research Outputs: 2025-Present

Heavy metal pollution represents a pervasive environmental challenge that significantly exacerbates the ever-increasing crisis of antimicrobial resistance and the capacity of microorganisms to endure and proliferate despite antibiotic interventions. This review examines the intricate relationship between heavy metals and AMR, with an emphasis on the underlying molecular mechanisms and ecological ramifications. Common environmental metals, including arsenic, mercury, cadmium, and lead, exert substantial selective pressures on microbial communities. These induce oxidative stress and DNA damage, potentially leading to mutations that enhance antibiotic resistance. Key microbial responses include the overexpression of efflux pumps that expel both metals and antibiotics, production of detoxifying …

Alternative To The Statistical Mass Confusion Of Testing For "No Effect", Josh L Morgan

2020-Current year OA Pubs

In cell biology, statistical analysis means testing the hypothesis that there was no effect. This weak form of hypothesis testing neglects effect size, is universally misinterpreted, and is disastrously prone to error when combined with high-throughput cell biology. The solution is for analysis of measurements to start and end with an interpretation of effect size. In this manuscript, I walk through some of the common critiques of significance testing and how they relate to experimental cell biology. I argue that careful consideration of effect size should be returned to its central position in the planning and discussion of cell biological …

An Ethanol-Induced Loss Of The Lipid Droplet-Associated Segregase Vcp/P97 Leads To Hepatic Steatosis, Sandhya Sen, Shaun Weller, Ryan J Schulze, Donglin Ding, Carol A Casey, Conrad Weihl, Mark A Mcniven

2020-Current year OA Pubs

The liver stores substantial numbers of neutral lipid organelles termed lipid droplets (LDs) that accumulate within hepatocytes in response to chronic ethanol (EtOH) consumption leading to hepatic steatosis. Mass spectrometry analysis of LDs isolated from EtOH-damaged rat livers revealed a substantial reduction in the valosin-containing protein ATPase (VCP/p97) that acts to remove targeted proteins from cellular membranes for degradation. Experimental disruption of VCP function resulted in an increase in LD content in hepatocytes and mouse livers along with a marked increase in LD-associated hydroxysteroid dehydrogenase (HSD17β13) known to contribute to hepatic steatosis. Surprisingly, treatment of hepatocytes with the proteasome inhibitor …

Breast Cancer Survival Rates And Determinants In Ethiopia: A Systematic Review And Meta-Analysis Of Longitudinal Studies, Abenezer M. Tafese, Meseker T. Fentie, Beminate L. Seifu, Angwach A. Asnake, Bikiltu D. Dirbaba, Abdisa G. Jara, Elsabeth Tizazu Asare, Brandon George

College of Population Health Faculty Papers

BACKGROUND: Breast cancer is the most common cancer and the leading cause of cancer mortality among women in Ethiopia, accounting for 32% of new cancer cases and 17.6% of cancer deaths. Despite its growing burden, comprehensive data on survival rates and contributing factors remain limited. This systematic review and meta-analysis aimed to synthesize existing data on breast cancer survival in Ethiopia and identify key determinants influencing outcomes.

METHODS: A comprehensive systematic search was conducted in PubMed, Web of Science, Scopus, Embase, and CINAHL to identify studies on breast cancer survival in Ethiopia published between January 2014 and August 2024. Eligible …

Data Registration Techniques For Optical Functional Brain Mapping, Abigail Magee

McKelvey School of Engineering Graduate Student Theses & Dissertations

Optical functional brain mapping presents a versatile, portable, and cost-effective alternative to conventional functional imaging techniques such as functional magnetic resonance imaging (fMRI). However, optical imaging does not inherently capture anatomical details and relies on existing structural imaging to generate accurate brain maps. By employing head models that incorporate participant-specific anatomy, imaging array placement, and the optical properties of underlying tissues, optical functional brain mapping can achieve results comparable to those of fMRI. Despite advances in registration techniques, the creation of atlas-derived yet participant-specific head models remains a significant challenge. My research endeavors to develop innovative registration and analysis pipelines …

I’D Rather (S)He Was Dead: Resurrection & Gender Transition In Superhero Comics, Jonathan Sexton, Eitan Runyan

Online Midwinter Seminar (OMS)

No abstract provided.

Silicon Is The Next Frontier In Plant Synthetic Biology, Aniruddha Acharya, Kaitlin Hopkins, Tatum Simms

Faculty Publications - Biological Sciences

Silicon has a striking similarity to carbon and is found in plant cells. However, there is no specific role that has been assigned to silicon in the life cycle of plants. The amount of silicon in plant cells is species specific and can reach levels comparable to macronutrients. Silicon is used extensively in artificial intelligence, nanotechnology, and the digital revolution, and thus can serve as an informational molecule such as nucleic acids. The diverse potential of silicon to bond with different chemical species is analogous to carbon; thus, it can serve as a structural candidate similar to proteins. The discovery …

Culturally Responsive Teaching: Identifying Conifers Through Science And Tradition, Madhav P. Nepal

iLEARN Teaching Resources

This lesson on plant taxonomy introduces students to the scientific system used to name, classify, and identify plant species, with a focus on conifer trees found in local environments. Students explore how observable traits—such as needle shape, cone structure, and bark texture—are used to group plants into categories that reflect their evolutionary relationships. Through a hands-on tree-walk activity, students use a simplified dichotomous key to identify at least five conifer species on or near school grounds. They then use digital plant ID tools to confirm their findings and compare traditional and modern identification methods. The lesson also emphasizes the hierarchical …

Sos (Save Our Skin)- A Hospital Acquired Pressure Injury Reduction Quality, Nicholas A. La Mar

Master's Projects and Capstones

Problem: Hospital-acquired pressure injuries (HAPIs) are a significant source of preventable harm. Often associated with increased patient morbidity, reduced quality of life, and substantial financial costs. In 2023, a Northern California level II trauma center reported 44 HAPI cases, with 25% occurring in the telemetry units. Despite a hospital-wide reduction in HAPIs in 2024, telemetry units accounted for 33% of the cases in the first quarter of 2025, highlighting a need for targeted intervention.

Context: The project was conducted in four adult inpatient telemetry units of a 241-bed level two trauma center. The units faced challenges with inconsistent adherence to …

Recent Advances In Developing Cell-Free Protein Synthesis Biosensors For Medical Diagnostics And Environmental Monitoring, Tyler P. Green, Joseph P. Talley, Bradley Charles Bundy

Faculty Publications

Cell-free biosensors harness the selectivity of cellular machinery without living cells’ constraints, offering advantages in environmental monitoring, medical diagnostics, and biotechnological applications. This review examines recent advances in cell-free biosensor development, highlighting their ability to detect diverse analytes including heavy metals, organic pollutants, pathogens, and clinical biomarkers with high sensitivity and specificity. We analyze technological innovations in cell-free protein synthesis optimization, preservation strategies, and field deployment methods that have enhanced sensitivity, and practical applicability. The integration of synthetic biology approaches has enabled complex signal processing, multiplexed detection, and novel sensor designs including riboswitches, split reporter systems, and metabolic sensing modules. …

Enhancing Patient Positioning Accuracy: Evaluating Daily Cone Beam Computed Tomography In The Halcyon System., Duong Thanh Tai, Luong Tien Phat, Tran Trung Kien, Nguyen Ngoc Anh, Nguyen Xuan Hai, Peter Sandwall, David Bradley, James C L Chow

Oncology Articles

BACKGROUND: Precise patient positioning is crucial for successful radiotherapy, ensuring accurate delivery of radiation to tumors while minimizing exposure to healthy tissues. Positional errors can significantly impact treatment efficacy and increase side effects. This study evaluates the effectiveness of daily cone beam computed tomography (CBCT) imaging in the Halcyon system for detecting and correcting patient misalignments across various cancer types and treatment sites.

METHODS: A retrospective analysis was conducted on 411 patients treated with the Varian Halcyon linear accelerator from August 2022 to August 2024. Patients were grouped based on tumor location: Head and Neck (118 patients), Chest (188 patients), …

Stem Cell-Derived Corneal Epithelium: Engineering Barrier Function For Ocular Surface Repair, Emily Elizabeth Fresenko, Jian-Xing Ma, Matthew Giegengack, Atalie Carina Thompson, Anthony Atala, Andrew J W Huang, Yuanyuan Zhang

2020-Current year OA Pubs

The cornea, the transparent anterior window of the eye, critically refracts light and protects intraocular structures. Corneal pathologies, including trauma, infection, chemical injury, metabolic diseases, genetic conditions, and age-related degeneration, can lead to significant visual impairment. While penetrating keratoplasty or full-thickness corneal transplantation remains a standard and effective intervention for severe corneal dysfunction, limitations in donor tissue availability and the risk of immunogenic graft rejection necessitate alternative therapeutic strategies. Furthermore, for cases of isolated epithelial disfunction, a full-thickness cornea graft may not be required or effective. This review examines the potential of corneal epithelial constructs derived from autologous stem cells …

Sex, The Body, And Learning Gender: Demons In The World Of The Five Gods, Erin Mcbrien

Online Midwinter Seminar (OMS)

No abstract provided.

She Chose Her Fate: The Genderqueer Women Of Tolkien And Freedom Beyond The Patriarchal Binary, Alicia Fox-Lenz, Grace Moone, Leah Hagan

Online Midwinter Seminar (OMS)

No abstract provided.

“Her Hair Was Held A Marvel Unmatched”: The Significance Of Long, Blonde Hair In Tolkien’S Imagination, Sara Brown

Online Midwinter Seminar (OMS)

No abstract provided.

The Lived Experience Of The Orgasm Gap In U.S. Cisgender Women In Heterosexual Relationships, Alina Beverly Vergara-Hegi

Walden Dissertations and Doctoral Studies

Women are not orgasming as often as men in heterosexual sexual encounters. Research has confirmed that sociocultural influences, gender differences, sexual perceptions, sexual miseducation, and relationship dynamics contribute to women’s negative sexual experiences. What has been missing is a better understanding of the experience of the orgasm gap and the role of gender ideology in women’s sexual experiences. This study explored the lived experience of the orgasm gap and gender ideology in nine cisgender women in long-term heterosexual relationships. Critical feminist theory was used as the lens to explore the meaning of sexual inequities in intimate long-term relationships. Using interpretative …

Correlation Measures In Metagenomic Data: The Blessing Of Dimensionality, Alessandro Fuschi, Alessandra Merlotti, Thi Dong Binh Tran, Hoan Nguyen, George M. Weinstock

Faculty Research 2025

Microbiome analysis has revolutionized our understanding of various biological processes, spanning human health and epidemiology (including antimicrobial resistance and hor- izontal gene transfer), as well as environmental and agricultural studies. At the heart of microbiome analysis lies the characterization of microbial communities through the quantification of microbial taxa and their dynamics. In the study of bacterial abundances, it is becoming more relevant to consider their relationship, to embed these data in the framework of network theory, allowing characterization of features like node relevance, pathways, and community structure. In this study, we address the primary biases encoun- tered in reconstructing networks …

Restoration At The Intersection Of Science And Outreach-The Working Woods Learning Forest, Katharine L. Stuble, David J. Burke, Samuel C. Harbol, Chad Knisely, Jessica Miller Mecaskey, Alexa S. Wagner, Michael Watson, Kevin E. Mueller

Biological, Geological, and Environmental Faculty Publications

Botanical gardens and arboreta have enormous (if often under-realized) potential to increase understanding of restoration as a predictive science while simultaneously serving as platforms promoting large-scale restoration by public and private stakeholders. Public gardens often have deep histories of both research and outreach and, increasingly, engagement in restoration efforts. As a team of researchers and practitioners, we share our experiences using a forest management manipulation at the Holden Arboretum for both research and outreach. Forest management is a key tool for enhancing biodiversity and ecosystem services in young forests. Known as the Working Woods Learning Forest, this restoration simultaneously serves …

How People With Borderline Personality Disorder Experience Addiction During The Process Of Treatment, Michael Paul Onesto

Walden Dissertations and Doctoral Studies

This study explored the lived experience of Borderline Personality Disorder (BPD) and substance use as a maladaptive coping mechanism during recovery, raising the question of whether recovery itself fosters comorbidity. The study was grounded on several theories, including Linehan’s biosocial model, the Cox and Klinger alcohol motivation model, the affect regulation model, and the self-medication hypothesis. These theories argue that substance use arises from emotional vulnerability, invalidating environment, and affect regulation efforts. The study employed a phenomenological qualitative approach to guide data collection and analysis. Interviews from 20 BPD patients and mental health care providers were completed. The thematic analysis …

The Experience Of Living With Infertility Among Women Of Color, Claudia Calvario

Walden Dissertations and Doctoral Studies

Infertility affects individuals across all cultural and socioeconomic backgrounds; however, the lived experiences of women of color navigating infertility remain underrepresented in research, health care, and policy. The purpose of this interpretative phenomenological analysis (IPA) study was to explore the lived experiences of infertility among women of color. The specific aims of the study were to (a) understand the significance of cultural values in shaping these experiences, with a focus on cultural norms surrounding motherhood and fertility, and (b) gain insight on the ways in which women of color seek assistance. The conceptual framework integrated the biopsychosocial model, stress and …

Effectiveness Of Cognitive-Behavioral Therapy For Generalized-Anxiety Disorders In Adolescents: A Systematic Review Using Pico Framework, Rajwa D. Suryanto, Prodio E. Gaharani, Salam Salsabila, Calista Aziz, Fitri A. Khaerani, Salsabila Athaya, Lulu A. Setyowati, Elisya Kartadikaria, Muhammad I. Djamaluddin, Renata B. Soewahju, Dian A. Pitaloka

Pharmacology and Clinical Pharmacy Research

A number of teenagers experience various levels of mental disorders, ranging from mild stress to Generalized Anxiety Disorder (GAD). According to the World Health Organization (WHO), approximately 264 million people suffer from anxiety disorders, including GAD, and this condition is a significant leading cause of suicide incidents, ranking sixth among serious mental health issues. From a societal perspective, Cognitive Behavioral Therapy (CBT) has the advantage of cost-effectiveness by minimizing the use of medications and enhancing productivity in education for adolescents receiving CBT. This study aims to conduct a systematic review of the existing literature on GAD in adolescents, using the …

Comprehensive In Silico Analysis Of Bioactive Compounds From Pyrrosia Piloselloides Leaves As Xanthine Oxidase Inhibitors, Masira Sinuhaji, Husnul Havid, Ysrafil Ysrafil, Fransisza D. Alexandra

Pharmacology and Clinical Pharmacy Research

This study aimed to evaluate the potential of bioactive compounds from Pyrrosia piloselloides leaves as xanthine oxidase (XO) inhibitors through an in silico approach. Methods included molecular docking and molecular dynamics simulations to identify the binding affinity of test compounds to XO. Among 59 screened compounds, 3 compounds (2,6,10,14,18,22-Tetracosahexaene, 6-Hydroxymethaqualone, and β-Sitosterol acetate) exhibited the lowest binding energy in comparison to the control, Allopurinol, with key residue contributions from GLU 802, ARG 880, and THR 1010. Molecular dynamics simulations confirmed the interaction stability, with β-Sitosterol acetate showing the lowest total binding free energy (-46.23 ± 0.66 kcal/mol). ADMET predictions revealed …

Antioxidant Properties Of N-Hexane Extract From Tobacco Leaves (Nicotiana Tabacum L.) Using 2,2-Diphenyl-1-Picrylhydrazil (Dpph) Method, Vinda M. Patricia, Dhea K. Az-Zahra, Taufik M. Fakih, Farendina Suarantika

Pharmacology and Clinical Pharmacy Research

Tobacco (Nicotiana tabacum L.) is a commercial plant that often used for making cigarettes. In 2012, the government issued regulations for the diversification of tobacco products besides cigarettes. Some of these diversified tobacco products include organic pesticides, anesthetics, cosmetic ingredients, and biochar as an alternative to coal. Therefore, in order to further to diversification of tobacco product, this study aimed to determine the antioxidant activity from n-hexane extract from leaves using the Soxhlet extraction method. Antioxidant activity was assessed by the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, while the total phenolic content was determined using the Folin-Ciocalteu method that allowed quantification of phenolic …