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2025

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Sga 57 Senate 2025-09-05 Minutes, Niu Student Government Association Senate Sep 2025

Sga 57 Senate 2025-09-05 Minutes, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.


The Influence Of Defects: Oxidation Of Non-Planar Transition Metal Model Catalysts, Maxwell Gillum Sep 2025

The Influence Of Defects: Oxidation Of Non-Planar Transition Metal Model Catalysts, Maxwell Gillum

Dissertations

Metal-catalyzed oxidation reactions are a major application of heterogeneous catalysis and are a widely applied synthetic route for the production of chemicals and reagents essential to modern society. However, as the intricacies of heterogeneous surface catalysis are slowly being unraveled, minute details of the catalytic environment have been revealed to play outsized roles in the catalytic activity of the surface. The experiments herein further investigate the interplay between surface geometry and the formation oxygen-induced surface structures. Understanding how defects influence surface reactivity is a necessary step in gaining the ability to accurately model heterogeneous catalytic environments. Two different aspects of …


Investigating Queer Asians' Accultrative Resilience And Wellbeing, Yiyu Cheng Sep 2025

Investigating Queer Asians' Accultrative Resilience And Wellbeing, Yiyu Cheng

Dissertations

This dissertation examines the role of resilience factors in moderating the effects of acculturative stress on the well-being of queer Asian Americans. A total of 181 survey responses were collected from queer-identified Asian Americans over the age of 18 residing in the United States. Using hierarchical multiple regression analysis, this study explores three models incorporating two identity resilience factors (ethnic identity salience and queer identity salience), two community resilience factors (ethnic community support and queer community support), and two intersectional resilience factors (queer Asian identity salience and queer Asian community support). Well-being was assessed through life satisfaction, negative affect, and …


“Buying Time Or Doing Harm?”: Tracing Contestation And Consensus In Debates On Puberty Blockers For Trans Youth, Dana R. Lavergne Sep 2025

“Buying Time Or Doing Harm?”: Tracing Contestation And Consensus In Debates On Puberty Blockers For Trans Youth, Dana R. Lavergne

Dissertations

The use of hormone blockers and other forms of gender affirming medical care for trans youth has emerged as a site of medical and political contestation, with 26 states passing legislation outlawing their use (Movement Advancement Project, 2024). Drawing from a multiple-methods approach, this dissertation examines the ways in which this contestation emerged and has been framed both in political case law and digital spaces, which a specific attunement toward how medical discourse is used to support arguments calling for either the allowance or ban of hormone blockers. This dissertation highlights the ways in which the families of trans youth …


Drawing The Curtain: A Grounded Theory Analysis Of The Conceptualizations Of Culture, Ethnicity And Race In Professional Training Materials For Child Life Certification, Kia Lee Ferrer Sep 2025

Drawing The Curtain: A Grounded Theory Analysis Of The Conceptualizations Of Culture, Ethnicity And Race In Professional Training Materials For Child Life Certification, Kia Lee Ferrer

Dissertations

Objectives: Certified Child Life Specialists (CCLS) are pediatric healthcare professionals primarily working in hospital settings to support children and families in navigating the developmental challenges of hospitalization, illness, and enduring medical treatment. Recognizing the presence of racial and ethnic health disparities, coupled with the field’s notable lack of diversity (98% White female), the child life workforce is increasingly acknowledging the undeniable evidence that discriminatory behaviors adversely affect a child’s life and well-being. As advances in the social sciences increasingly reveal that discrimination functions as a "socially transmitted disease" in a child's life, I predict that the failure of child life …


Parental Autonomy Support And Children’S Affect As Predictors Of Children’S Stem Engagement In An Informal Educational Context, Bianca Martins Aldrich Sep 2025

Parental Autonomy Support And Children’S Affect As Predictors Of Children’S Stem Engagement In An Informal Educational Context, Bianca Martins Aldrich

Dissertations

In this project, we examined relations between parental talk and children’s affect on children’s STEM talk during an engineering-related activity (i.e., tinkering) in a local children’s museum. We characterized children’s affect in terms of valence (positive or negative) and activation (activating or deactivating), and parental talk was characterized as autonomy supportive or directive, as well as STEM-related or not. Parents and their 4- to 10-year-old children were recruited at the entrance of the Tinkering Lab exhibit at Chicago Children’s Museum. Parents and children were video and audio recorded during the activity. We coded parents’ and children’s behaviors using a time-sampling …


Forgive As We Are Forgiven: Reframing A Trinitarian Model Of Forgiveness In A Post-Genocide Rwanda, Deogratias Mbonyumugenzi Sep 2025

Forgive As We Are Forgiven: Reframing A Trinitarian Model Of Forgiveness In A Post-Genocide Rwanda, Deogratias Mbonyumugenzi

Dissertations

This dissertation seeks to develop a theological model of forgiveness rooted in a relational conception of the Trinity. The central argument of this dissertation is that the model of forgiveness practiced in post-genocide Rwanda and the forgiveness modeled by Jesus, and testified to in the New Testament and developed in the Christian tradition, are good, but not sufficient to address the kind of trauma and human disrepair, as well as the devastation of communities, inflicted by genocide. Rather, a theology of forgiveness modeled on a relational conception of the Trinity and its practical implications for a Trinitarian ecclesiology and anthropology …


Effectiveness Of A Classroom-Based Stress Awareness And Coping Skills Program Among Adolescents From Diverse Backgrounds, Adriane Van Zwoll Sep 2025

Effectiveness Of A Classroom-Based Stress Awareness And Coping Skills Program Among Adolescents From Diverse Backgrounds, Adriane Van Zwoll

Dissertations

The ongoing youth mental health crisis in the United States, worsened by the COVID-19 pandemic, has highlighted the urgent need for accessible and effective school-based interventions. This dissertation evaluates the effectiveness of Stress Less: Resilience for Success™, a single-session, classroom-based stress awareness and coping skills program implemented by NAMI Metro Suburban in diverse middle and high schools in the western suburbs of Chicago from 2018 to 2024. Using the CDC’s Framework for Program Evaluation, this study analyzes secondary data from 7,225 pre-test and post-test surveys and is complemented by qualitative informational interviews with current and former NAMI staff and volunteers …


Association Between Body Mass Index And Uterotonic Use In Postpartum Hemorrhage: A Retrospective Cohort Study, Cece Cheng, Bryce T Munter, Michaela Y Lee, Claire D Sundjaja, Natasha D Paul, Margaret M Klausmeyer, Nastassia A Yammine, Patrick S Ramsey, John J Byrne Sep 2025

Association Between Body Mass Index And Uterotonic Use In Postpartum Hemorrhage: A Retrospective Cohort Study, Cece Cheng, Bryce T Munter, Michaela Y Lee, Claire D Sundjaja, Natasha D Paul, Margaret M Klausmeyer, Nastassia A Yammine, Patrick S Ramsey, John J Byrne

Faculty, Staff and Student Publications

Background/Objectives: Our primary objective was to determine whether patients with a higher body mass index (BMI) who experienced postpartum hemorrhage (PPH) required ≥2 uterotonics more often than those with lower BMI.

Methods: We conducted a retrospective cohort study that included all patients who experienced a PPH between 1 August 2020 and 31 July 2022. Extracted data included patient demographics, PPH risk factors, details regarding the labor course and hemorrhage management, and maternal and neonatal outcomes, such as mode of delivery, etiology of hemorrhage, need for nonpharmacological management, neonatal Apgar scores, requirement for phototherapy, neonatal intensive care unit (NICU) admission, and …


An Evolutionary Preamble Towards A Multilevel Framework To Understand Adolescent Mental Health: An International Delphi Study, Federica Sancassiani, Vanessa Barrui, Fabrizio Bert, Sara Carucci, Fatma Charfi, Giulia Cossu, Arne Holte, Jutta Lindert, Simone Marchini, Alessandra Perra, Samantha Pinna, Antonio Egidio Nardi, Alessandra Scano, Cesar A Soutullo, Massimo Tusconi, Diego Primavera Sep 2025

An Evolutionary Preamble Towards A Multilevel Framework To Understand Adolescent Mental Health: An International Delphi Study, Federica Sancassiani, Vanessa Barrui, Fabrizio Bert, Sara Carucci, Fatma Charfi, Giulia Cossu, Arne Holte, Jutta Lindert, Simone Marchini, Alessandra Perra, Samantha Pinna, Antonio Egidio Nardi, Alessandra Scano, Cesar A Soutullo, Massimo Tusconi, Diego Primavera

Faculty, Staff and Student Publications

Background/objectives: Adolescence is a sensitive developmental window shaped by both vulnerabilities and adaptive potential. From an evolutionary standpoint, mental health difficulties in this period may represent functional responses to environmental stressors rather than mere dysfunctions. Despite increasing interest, integrative models capturing the dynamic interplay of risk and protective factors in adolescent mental health remain limited. This study presents a holistic, multi-level framework grounded in ecological and evolutionary theories to improve understanding and intervention strategies.

Methods: A two-round Delphi method was used to develop and validate the framework. Twelve experts in adolescent mental health evaluated a preliminary draft derived from the …


Identifying Bio-Behavioural Signatures Of Persistent Opioid Use Risk In Trauma Injury Patients: A Protocol For A Prospective Cohort Study, Joy M Schmitz, Jin Ho Yoon, Bruno Kluwe-Schiavon, John A Harvin, Preethi H Gunaratne, Darrion Mouton, Kandice Motley, Erin E Fox, Jessica Vincent, Megan Tarbet, Consuelo Walss-Bass Sep 2025

Identifying Bio-Behavioural Signatures Of Persistent Opioid Use Risk In Trauma Injury Patients: A Protocol For A Prospective Cohort Study, Joy M Schmitz, Jin Ho Yoon, Bruno Kluwe-Schiavon, John A Harvin, Preethi H Gunaratne, Darrion Mouton, Kandice Motley, Erin E Fox, Jessica Vincent, Megan Tarbet, Consuelo Walss-Bass

Faculty, Staff and Student Publications

Introduction: Exposure to prescription opioids following traumatic injury can increase the risk of developing tolerance, persistent opioid use and opioid use disorder. The mechanisms underlying opioid tolerance or dependence are not well understood, and no biomarkers predict risk. Opioid exposure causes epigenetic modifications, including alterations in microRNA (miRNA) expression. Several miRNAs, which regulate synaptic plasticity, are hypothesised to underlie substance use disorders and influence µ-opioid receptor levels, modulating opioid tolerance. This project aims to develop a bio-behavioural signature to predict persistent opioid use and chronic pain up to 6 months post-discharge.

Methods and analysis: The study will use a prospective …


Cocoa Polyphenols Modulate The Mouse Gut Microbiome In A Site-Specific Manner, Marcus Hayden, Eliza C. Stewart, Mohammed F. Almatani, Jeremy Case, Samuel Rice, Giovanni Rompato, Korry J. Hintze, Abby D. Benninghoff Sep 2025

Cocoa Polyphenols Modulate The Mouse Gut Microbiome In A Site-Specific Manner, Marcus Hayden, Eliza C. Stewart, Mohammed F. Almatani, Jeremy Case, Samuel Rice, Giovanni Rompato, Korry J. Hintze, Abby D. Benninghoff

Animal, Dairy, and Veterinary Science Student Research

Background/Objectives: The dietary modulation of the gut microbiome is a promising strategy for mitigating gastrointestinal diseases, such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Cocoa powder is rich in polyphenols, including (−)-epicatechin and (+)-catechin, which have been associated with beneficial effects on gut health and microbiome modulation. Importantly, changes in the bacterial populations associated with the gut mucosal layer may have different health impacts compared to changes in cecal or fecal microbiomes. This study investigated the effects of cocoa polyphenol supplementation on microbiome composition across the cecal, fecal, and mucosal compartments in a mouse model of colitis. …


Blue Light As An Anti-Inflammatory And Analgesic Strategy In Thoracic Trauma (Blaastt): Protocol For A Randomised Controlled Trial In Adult Trauma Inpatients With Painful Rib Fractures, Rebecca E Kotcher, Matthew R Rosengart, Luca La Colla, Hsing-Hua Sylvia Lin, Keith M Vogt, Yan Xu, Matthew D Neal Sep 2025

Blue Light As An Anti-Inflammatory And Analgesic Strategy In Thoracic Trauma (Blaastt): Protocol For A Randomised Controlled Trial In Adult Trauma Inpatients With Painful Rib Fractures, Rebecca E Kotcher, Matthew R Rosengart, Luca La Colla, Hsing-Hua Sylvia Lin, Keith M Vogt, Yan Xu, Matthew D Neal

2020-Current year OA Pubs

INTRODUCTION: Blue light (peak wavelength 442 nm) has been shown to modulate the immune response in preclinical models of intra-abdominal sepsis and pneumonia.

METHODS AND ANALYSIS: This is a randomised controlled trial in which adult trauma inpatients (

ETHICS AND DISSEMINATION: Full ethical approval for this trial has been granted by the University of Pittsburgh Institutional Review Board. On study completion, results will be published in the peer-reviewed literature and at ClinicalTrials.gov.

TRIAL REGISTRATION NUMBER: NCT06626334.


Opportunities In Emergency Preparedness Through Community Partnerships, Katie Hooven Sep 2025

Opportunities In Emergency Preparedness Through Community Partnerships, Katie Hooven

International Nursing Research Congress (INRC)

The two-part project was primarily focused on expanding disaster management and emergency preparedness learning experiences in our nursing courses by partnering with our local community agencies.

To diversify our student experience and work within our local community we established a mutually beneficial partnership to create an opportunity to expose students to emergency management and disaster preparedness. We asked the local County Medical Reserve Corporation Coordinator to partner with us to offer their eight required training courses which would allow interested sophomore students to become MRC members. The national MRC organization developed the MRC Core Competencies as a guide for training …


Creating The Thomas Mcrae Sanitorium For Negros: Race, Contagion, And Space In Jim Crow Arkansas, Shauna Gibbons Sep 2025

Creating The Thomas Mcrae Sanitorium For Negros: Race, Contagion, And Space In Jim Crow Arkansas, Shauna Gibbons

The Ozark Historical Review

The Thomas McRae Memorial Sanatorium for Negroes, located in Alexander, Arkansas, opened its doors in 1931 as the only resource for the entire state’s population of consumptive African Americans. It was touted as one of the best of its kind under the supervision of Dr Hugh A. Browne. But its “kind” was a facility intended for individuals whom whites in the medical and political establishment viewed not only as second class citizens but as biologically and medically different.


Retracted: Hotspot Issue Handling And Reliable Data Forwarding Technique For Ocean Underwater Sensor Networks, Omar Adil Mahdi, Yusor Rafid Bahar Al-Mayouf, Sameer Sami Hassan Al-Obaidi, Bourair Al-Attar, Hamed Balogun, Suleman Khan Sep 2025

Retracted: Hotspot Issue Handling And Reliable Data Forwarding Technique For Ocean Underwater Sensor Networks, Omar Adil Mahdi, Yusor Rafid Bahar Al-Mayouf, Sameer Sami Hassan Al-Obaidi, Bourair Al-Attar, Hamed Balogun, Suleman Khan

Iraqi Journal for Computer Science and Mathematics

Underwater Wireless Sensor Networks (UWSNs) have emerged as a promising technology for a wide range of ocean monitoring applications. The UWSNs suffer from unique challenges of the underwater environment, such as dynamic and sparse network topology, which can easily lead to a partitioned network. This results in hotspot formation and the absence of the routing path from the source to the destination. Therefore, to optimize the network lifetime and limit the possibility of hotspot formation along the data transmission path, the need to plan a traffic-aware protocol is raised. In this research, we propose a traffic-aware routing protocol called PG-RES, …


Student Newsletter Fall 2025, University Of Missouri-St. Louis Libraries Sep 2025

Student Newsletter Fall 2025, University Of Missouri-St. Louis Libraries

Library Publications

No abstract provided.


The Force Of Resilience: Exploration Of Correlations Between Generational Differences In Occupational Resilience And Turnover Intentions Among Active United States Law Enforcement Personnel, Kaylin Elizabeth Switzer Sep 2025

The Force Of Resilience: Exploration Of Correlations Between Generational Differences In Occupational Resilience And Turnover Intentions Among Active United States Law Enforcement Personnel, Kaylin Elizabeth Switzer

Walden Dissertations and Doctoral Studies

Law enforcement agencies across the United States are facing critical challenges with the recruitment and retention of officers. This study examined whether differences existed in occupational resilience and turnover intentions across generations of active law enforcement personnel, and whether resilience levels were correlated with turnover intentions. A quantitative, cross-sectional design was used to collect data via an online survey that included the Predictive 6-Factor Resilience Scale and the Expanded Multidimensional Turnover Intentions Scale. The sample consisted of 241 active members of law enforcement. There were two one-way ANOVA tests conducted to assess generational differences in resilience and turnover intention scores, …


September 2025 General Education Council Minutes, University Of Nebraska At Kearney General Education Council Sep 2025

September 2025 General Education Council Minutes, University Of Nebraska At Kearney General Education Council

General Education Council

No abstract provided.


Magnolia Tapichalacaensis (Magnoliaceae), A New Species From The Andean Foothills Of Zamora Chinchipe, Ecuador, Álvaro J. Pérez, Edison Rea, Jennifer Martínez, Fanny Hidalgo, Franco Mendoza, Ramiro Mendoza, Nelson Jaramillo Díaz, Fredy Archila, Kevin S. Burgess, Rosana Zenil-Ferguson, J. Antonio Vázquez-García Sep 2025

Magnolia Tapichalacaensis (Magnoliaceae), A New Species From The Andean Foothills Of Zamora Chinchipe, Ecuador, Álvaro J. Pérez, Edison Rea, Jennifer Martínez, Fanny Hidalgo, Franco Mendoza, Ramiro Mendoza, Nelson Jaramillo Díaz, Fredy Archila, Kevin S. Burgess, Rosana Zenil-Ferguson, J. Antonio Vázquez-García

Biology Faculty Publications

The number of new species of Ecuadorian Magnolia Linnaeus (1753: 535) continues to increase as exploration of the Andes progresses. Currently, 24 species of Magnolia are recorded for Ecuador (Vázquez-García et al. 2012, 2013, 2015a, 2015b, 2016, 2017, 2018, Arroyo et al. 2013a, 2013b, 2019, Pérez et al. 2016, 2023), which belong to M. sect. Splendentes Dandy in Vázquez (1994: 4) and Talauma Baillon (1866: 3) (Wang et al. 2020), the former consisting of six species, including the new species described here, and the latter 19 species. There are 17 endemic species in Ecuador, three of which also occur in …


September 2025, Pacific Alumni Association Sep 2025

September 2025, Pacific Alumni Association

Alumni News & Events

No abstract provided.


Air Pollution And Diseases: Signaling, G Protein-Coupled And Toll Like Receptors, Isabella Cattani-Cavalieri, Katrina F. Ostrom, Jordyn Margolis, Rennolds S. Ostrom, Martina Schmidt Sep 2025

Air Pollution And Diseases: Signaling, G Protein-Coupled And Toll Like Receptors, Isabella Cattani-Cavalieri, Katrina F. Ostrom, Jordyn Margolis, Rennolds S. Ostrom, Martina Schmidt

Pharmacy Faculty Articles and Research

Air pollution is a significant public health issue that impacts lung health, particularly in vulnerable populations such as children, the elderly, and individuals with pre-existing respiratory conditions. Both natural and anthropogenic sources of air pollution give rise to a variety of toxic compounds, including particulate matter (PM), ozone (O₃), sulfur dioxide (SO₂), nitrogen dioxide (NO₂), carbon monoxide (CO), and polycyclic aromatic hydrocarbons (PAHs). Exposure to these pollutants is strongly associated with the development and exacerbation of respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and idiopathic pulmonary fibrosis (IPF). Notably, early life exposure to pollutants such as …


Temporal Variability In Grassland Leaf Water Content Is Strongly And Similarly Dependent On Soil Moisture Among Dominant Grasses, Henry K. Joniak, Andrew Felton Sep 2025

Temporal Variability In Grassland Leaf Water Content Is Strongly And Similarly Dependent On Soil Moisture Among Dominant Grasses, Henry K. Joniak, Andrew Felton

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

Vegetation in semi-arid rangeland ecosystems is typically characterized by the presence of a few dominant grass species that control ecosystem processes and, by extension, ecosystem services such as forage production. Thus, understanding and comparing the responses of dominant forage species to climatic variability can lend insight into how functioning and services in these ecosystems will respond to climate change. Here, we designed a transect-based study to assess and compare the temporal relationship between soil moisture (volumetric water content, VWC) and a key functional trait (leaf water content, LWC) among two of the dominant forage grass species in Southwestern Montana. Sampling …


Climate Change-Related Threats To Railroads: Implications For Threat, Hazard And Risk Assessment, Frances L. Edwards, Daniel C. Goodrich Sep 2025

Climate Change-Related Threats To Railroads: Implications For Threat, Hazard And Risk Assessment, Frances L. Edwards, Daniel C. Goodrich

Faculty Research, Scholarly, and Creative Activity

Climate change has created new challenges for railroads around the world. The rail systems operate in open environments, subjecting them to increased heat, changing locations of heavy rains, developing sea level rise and storm surge, and a longer and stronger wildfire season. This research investigates how an updated threat and hazard identification and risk assessment (THIRA) can lead to the development of climate adaptation strategies that limit damage and disruption to the railroad enterprise. The THIRA analyzes which threats are of most concern in a specific rail segment, and which climate change adaptation strategies give a beneficial return on investment.


Montana Kaimin, September 4, 2025, Students Of The University Of Montana, Missoula Sep 2025

Montana Kaimin, September 4, 2025, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.


Lewy Body Dementia Promotion By Air Pollutants, Xiaodi Zhang, Haiqing Liu, Xiao Wu, Longgang Jia, Kundlik Gadhave, Lena Wang, Kevin Zhang, Hanyu Li, Rong Chen, Ramhari Kumbhar, Ning Wang, Chantelle E Terrillion, Bong Gu Kang, Bin Bai, Minhan Park, Ma Cristine Faye Denna, Shu Zhang, Wenqiang Zheng, Denghui Ye, Xiaoli Rong, Liu Yang, Lili Niu, Han Seok Ko, Weiyi Peng, Lingtao Jin, Mingyao Ying, Liana S Rosenthal, David W Nauen, Alex Pantelyat, Mahima Kaur, Kezia Irene, Liuhua Shi, Rahel Feleke, Sonia García-Ruiz, Mina Ryten, Valina L Dawson, Francesca Dominici, Rodney J Weber, Xuan Zhang, Pengfei Liu, Ted M Dawson, Shizhong Han, Xiaobo Mao Sep 2025

Lewy Body Dementia Promotion By Air Pollutants, Xiaodi Zhang, Haiqing Liu, Xiao Wu, Longgang Jia, Kundlik Gadhave, Lena Wang, Kevin Zhang, Hanyu Li, Rong Chen, Ramhari Kumbhar, Ning Wang, Chantelle E Terrillion, Bong Gu Kang, Bin Bai, Minhan Park, Ma Cristine Faye Denna, Shu Zhang, Wenqiang Zheng, Denghui Ye, Xiaoli Rong, Liu Yang, Lili Niu, Han Seok Ko, Weiyi Peng, Lingtao Jin, Mingyao Ying, Liana S Rosenthal, David W Nauen, Alex Pantelyat, Mahima Kaur, Kezia Irene, Liuhua Shi, Rahel Feleke, Sonia García-Ruiz, Mina Ryten, Valina L Dawson, Francesca Dominici, Rodney J Weber, Xuan Zhang, Pengfei Liu, Ted M Dawson, Shizhong Han, Xiaobo Mao

Faculty, Staff and Student Publications

Evidence links air pollution to dementia, yet its role in Lewy body dementia (LBD) remains unclear. Here we showed in a cohort of 56.5 million individuals across the U.S. that PM2.5 exposure raises LBD risk. Mechanistically, we found PM2.5 exposure led to brain atrophy in wild-type mice, an effect not seen in α-synuclein (αSyn)-deficient mice. PM2.5 exposure generated a highly pathogenic αSyn strain, PM-PFF, with enhanced proteinase K-resistance and neurotoxicity, resembling αSyn LBD strains. PM2.5 samples from China, the U.S., and Europe consistently induced proteinase-resistant αSyn strains and in vivo pathology. Transcriptomic analyses revealed shared responses between PM2.5-exposed mice and …


Dissecting Microbial Communities With Single-Cell Transcriptome Analysis, Andrew W Pountain, Itai Yanai Sep 2025

Dissecting Microbial Communities With Single-Cell Transcriptome Analysis, Andrew W Pountain, Itai Yanai

Faculty, Staff and Student Publications

Revealing insights into the function of microbial communities requires moving beyond measuring bulk taxonomic composition to detecting interactions between subpopulations. Following the transformative impact of single-cell gene expression profiling techniques on numerous fields of human biology, recent years have seen increased application to microbes. We review progress in the development of these techniques and discuss challenges in applying them to microbial communities. We highlight applications for dissecting the microbiome in human health and disease that reveal functional heterogeneity within gut communities, antibiotic responses, and the dynamics of mobile genetic elements. As single-cell gene expression technologies continue to develop, they are …


Human Papillomavirus Integration Induces Oncogenic Host Gene Fusions In Oropharyngeal Cancers, Nusrat Khan, Keiko Akagi, Shiming Jiang, Joe Dan Dunn, Bo Jiang, Weihong Xiao, Madison P O'Hara, Li Shen, Qi Wang, Vakul Mohanty, Jing Wang, Sara Goodwin, Jamie L Hutchins, Kevin R Coombes, Jagannadha K Sastry, David E Symer, Maura L Gillison Sep 2025

Human Papillomavirus Integration Induces Oncogenic Host Gene Fusions In Oropharyngeal Cancers, Nusrat Khan, Keiko Akagi, Shiming Jiang, Joe Dan Dunn, Bo Jiang, Weihong Xiao, Madison P O'Hara, Li Shen, Qi Wang, Vakul Mohanty, Jing Wang, Sara Goodwin, Jamie L Hutchins, Kevin R Coombes, Jagannadha K Sastry, David E Symer, Maura L Gillison

Faculty, Staff and Student Publications

HPV integration disrupts host genomic structure and expression, but whether these alterations promote cancer development remains unclear. Multiple genomic analyses of oropharyngeal cancers identified several host fusion genes, including recurrent FGFR3-TACC3 fusions, expressed from rearranged genomic loci adjacent to HPV integration sites. Evolutionary modeling implicated integration of virus concatemers into the host genome as a common initiating event in fusion formation. Co-expression of HPV16 E6/E7 and FGFR3-TACC3, but neither alone, was sufficient for tumor development in both xenograft and syngeneic mouse models and led to unique transcriptional programs implicated in carcinogenesis. FGFR3-TACC3 expression decreased the ubiquitination and degradation of …


September 4, 2025, The Daily Mississippian Sep 2025

September 4, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.


What Are The Lived Experiences Of Policing Professionals With Self-Reported Alterations To Biological Instinct Alongside Operational Demands?, Madyson Wier Sep 2025

What Are The Lived Experiences Of Policing Professionals With Self-Reported Alterations To Biological Instinct Alongside Operational Demands?, Madyson Wier

Walden Dissertations and Doctoral Studies

Operational demands and training of policing professionals may be a source of conflict leading to a potential increase in risk for both the officer and the general public. Training in a law enforcement academy does not adequately prepare officers for the impacts the career may have on mental health, changes to the biological system, or societal criticism of modern-day policing. The purpose of this qualitative study was to understand how policing professionals experience changes in the autonomic nervous system with exposure to trauma in the field, and how self-reported alterations are further impacted due to operational expectations of their department. …