Digital Commons Network^™

Sex-Specific Associations Between Early Life Unpredictability And Trajectories Of Body Mass Index From Infancy To Adolescence, Emily M. Melnick, Lilybelle K. Deer, Jenalee R. Doom, Hal S. Stern, Curt A. Sandman, Laura M. Glynn, Elysia P. Davis

Psychology Faculty Articles and Research

Objective:

Unpredictability in early life is an understudied aspect of early life adversity that provides important signals to the child about their environment. Recent work shows the predictability of patterns of parental signals on a moment-to-moment timescale sculpts the developing brain during sensitive windows, offering a potential pathway through which early life experiences shape child development. Both experimental non-human animal models and observational human research show sex-specific links between early life exposure to unpredictable patterns of parental sensory signals and aberrant offspring development. The impact of predictability of sensory signals on physical health outcomes, such as BMI, remains unknown. Here …

Defining Breast Epithelial Cell Types In The Single-Cell Era, G Kenneth Gray, Eric G Carlson, Tatyana Lev, Bailey Marshall, Austin D Reed, Alex P Sánchez-Covarrubias, Alecia-Jane Twigger, Aleix Puig-Barbe, Aatish Thennavan, Ayodele Omotoso, Lyndsay M Murrow, Deeptiman Chatterjee, Siyuan He, Sara Pensa, Brian Aevermann, Norbert K Tavares, Natalie Chen, Jason A Hilton, Kerrigan Blake, Yunlong Liu, Kiet Phong, Zev J Gartner, Devon A Lawson, Alexander Swarbrick, Camila O Dos Santos, Sophia H L George, Joan S Brugge, Mark A Labarge, Harikrishna Nakshatri, Nicholas Navin, Kai Kessenbrock, Walid T Khaled

Faculty, Staff and Student Publications

Single-cell studies on breast tissue have contributed to a change in our understanding of breast epithelial diversity that has, in turn, precipitated a lack of consensus on breast cell types. The confusion surrounding this issue highlights a possible challenge for advancing breast atlas efforts. In this perspective, we present our consensus on the identities, properties, and naming conventions for breast epithelial cell types and propose goals for future atlas endeavors. Our proposals and their underlying thought processes aim to catalyze the adoption of a shared model for this tissue and to serve as guidance for other investigators facing similar challenges.

Increased Risk Of Postoperative Complications In Patients With Hypertension Undergoing Mohs Micrographic Surgery, Alexandra Elder, Henry Yang, Megan O'Donnell-Capelli, Jenna Mandel, Molly Wallace, Lauren Banner, Ramsay Hafer, Thomas Rohan, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

Hypertension has been previously associated with higher intraoperative bleeding risk in patients undergoing Mohs micrographic surgery. However, the risks of common postoperative Mohs micrographic surgery complications have not been substantiated by large studies. Our study aimed to assess the risks of common Mohs micrographic surgery complications for patients with hypertension utilizing the TriNetX database, a global health records database encompassing over 105 million patients' data, from January 2009 to January 2024. After 1:1 propensity score matching for age, sex, race, diabetes, nicotine dependence, obesity, and anticoagulant use, the final analysis included 80,739 patients in each cohort of patients with hypertension …

Lanthorn, Vol. 60, No. 03, September 8, 2025, Grand Valley State University

Volume 60, August 4, 2025 – April 20, 2026

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Integrative Analysis Of Lung Adenocarcinoma Across Diverse Ethnicities And Exposures, Shankha Satpathy, Natalie M Clark, Yi-Ju Chen, Noshad Hosseini, Ya-Hsuan Chang, Yi Hsiao, Jonathan T Lei, Francesca Petralia, Jin-Shing Chen, Yifat Geffen, David I Heiman, Indranil Paul, Hanbyul Cho, Michelle Hollenberg, Giacomo B Marino, Kuen-Tyng Lin, Rahul Mannan, C Jackson White, Joe Allen, Shayan C Avanessian, M Harry Kane, Ashley Wolfe, Miloni Kinarivala, Wenke Liu, Shankara Anand, Mong-Wei Lin, Moe Haines, Erik J Bergstrom, Grant Hussey, Ginny Xiaohe Li, Deepak C Mani, Hao Fang, Eric J Jaehnig, Hasmik Keshishian, Brecca Miller, Kang-Yi Su, Yi-Jing Hsiao, Hsao-Hsun Hsu, Min-Shu Hsieh, Kuo-Hsuan Hsu, Alexi Monovoukas, Simone Gohsman, John R Thorup, Yamei Deng, Yo Akiyama, Eden Deng, Eric Sheng-Wen Chen, Azra Krek, Rodrigo Espinoza, Weiping Ma, Daniel Charytonowicz, Robert Sebra, Jyun-Hong Lin, Yan-Si Chen, Yin-Chen Hsu, Ze-Shiang Lin, Kun-Chieh Chen, Chang-Wei Yeh, Yu-Tai Wang, Alexander J Lazar, Mehdi Mesri, Eunkyung An, Xu Zhang, Karl R Clauser, David Fenyö, Arul M Chinnaiyan, Bing Zhang, Li Ding, Kelly Ruggles, Chelsea Newton, Hui Zhang, Pei Wang, Galen Hostetter, Gilbert S Omenn, Chandan Kumar-Sinha, Mathangi Thiagarajan, Ramaswamy Govindan, Paul Paik, Abhijit Parolia, Qing K Li, Avi Ma'ayan, Gad A Getz, Saravana M Dhanasekaran, Ana I Robles, Gee-Chen Chang, Pan-Chyr Yang, Sung-Liang Yu, Hsuan-Yu Chen, Alexey I Nesvizhskii, Steven A Carr, D R Mani, Marcin P Cieslik, Yu-Ju Chen, Michael A Gillette, Taiwan Cancer Moonshot Program, Clinical Proteomic Tumor Analysis Consortium

Faculty, Staff and Students Publications

Lung adenocarcinomas (LUAD) are a pressing global health problem with enduring lethality and rapidly shifting epidemiology. Proteogenomic studies integrating proteomics and post-translational modifications with genomics can identify clinical strata and oncogenic mechanisms, but have been underpowered to examine effects of ethnicity, smoking and environmental exposures, or sex on this heterogeneous disease. This comprehensive proteogenomic analysis of LUAD tumors and matched normal adjacent tissues from 406 patients across diverse geographic and demographic backgrounds explores the impact of understudied driver mutations, prognostic role of chromosomal instability, patterns of immune signaling, differential and sex-specific effects of endogenous mutagens and environmental carcinogens, and pathobiology …

Metabolic Biochemical Models Of N Fixation For Sulfide Oxidizers, Methanogens, And Methanotrophs, Meng Gao, Megan Berberich, Reid Brown, David M. Costello, James B. Cotner, Julian Damashek, Leila Richards Kittu, Ada Pastor, Robinson W. Fulweiler, J Thad Scott, Amy Marcarelli, Keisuke Inomura

Michigan Tech Publications

Dinitrogen (N) fixation provides bioavailable nitrogen to the biosphere. However, in some habitats (e.g., sediments), the metabolic pathways of organisms carrying out N fixation are unclear. We present metabolic models representing various chemotrophic N fixers, which simulate potential pathways of electron transport and energy flow, resulting in predictions of whole-cell stoichiometries. By balancing mass, electrons, and energy for metabolic half-reactions, we quantify the electron usage for nine N fixers. Our results demonstrate that all modeled organisms fix sufficient N for growth. Aerobic organisms allocate more electrons to N fixation and growth, yielding more biomass and fixing more N, while methanogens …

Increased Circulating Th17 Cells And Altered Cd4 T Cell Maturation And Differentiation In Active Tuberculosis With Type 2 Diabetes: A Pilot Study, Paul Ogongo, Yoscelina Estrella Martinez-Lopez, Anthony Tran, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Ilse A. Dominguez-Trejo, Genesis P. Aguillón-Durán, Esperanza M. Garcia-Oropeza, Blanca I. Restrepo

School of Medicine Publications

Introduction: Type 2 diabetes (T2D) is a major risk factor for developing tuberculosis (TB). However, understanding the role of defective T cell responses in T2D and TB has been difficult, largely due to inconsistencies across studies. These discrepancies often stem from T cell subset classification primarily relying on cytokine expression profiles, which may not fully capture the complexity of T cell maturation, differentiation, and function in TB patients with T2D.

Objective and methods: In this pilot study, we sought to identify alterations in phenotypic and ex vivo responses of CD4 T cells to Mycobacterium tuberculosis (Mtb) antigens in people with …

Results Of Tor001: An Open-Label Single Patient Study Using Targeted Bacteriophage Therapy For The Treatment Of A Chronic Urinary Tract Infection, Jonathan D Cook, Payton B Hooey, Keiko C Salazar, Justin R Clark, Umesh Jain, Carlos Fernando, Hanjeong Harvey, Alexander Cervantes, Stephanie Omagari, Udi Blankstein, Andrew M Kropinski, Alan R Davidson, Karen L Maxwell, Lori L Burrows, Austen L Terwilliger, Anthony W Maresso, Greg J German

Faculty, Staff and Students Publications

Chronic urinary tract infections are persistent bacterial infections with the potential to drive antibiotic resistance. Like other persistent bacterial infections, intracellular bacterial reservoirs and biofilm formation hinder the clearance of pathogens despite long courses of antibiotic therapy. New strategies for treatment of these persistent infections are needed. Here we describe the results of an open-label individual patient study using bacteriophage therapy to treat a chronic urinary tract infection in an immunocompetent 72-year-old woman without underlying urolithiasis or indwelling devices. We co-administered HP3.1, HP3, and ES19 bacteriophages with demonstrated in vitro activity via bladder instillation, orally, and as a topical formulation. …

Intestinal Microbiome Changes In Response To Amino Acid And Micronutrient Supplementation: Secondary Analysis Of The Amaze Trial, Monica N Mweetwa, Kazi Ahsan, John Louis-Auguste, Ellen Besa, Joram M Posma, Nathan Mcnulty, Micheal J Barrat, Jeff Gordon, Paul Kelly

2020-Current year OA Pubs

Microbial dysbiosis has been linked to environmental enteropathy (EE) and alterations in nutrient absorption; however, compositional modifications following exposure to supplementary nutrients are poorly understood. Here, we report the effect of amino acid and micronutrient supplementation on the gut microbiome of adults with EE. In the AMAZE trial, adults with EE were randomized to amino acids (AA) and/or micronutrients (MM) for 16 weeks in a 2 × 2 factorial design against placebo. Endoscopy was performed before and after intervention, during which duodenal aspirates were collected as well as fecal samples. 16S rRNA amplicon sequencing was performed on both these samples, …

Chemo-Rast With Bortezomib Inhibits Multiple Myeloma Relapse, Anchal Ghai, Alexander Zheleznyak, Christopher Egbulefu, Nicole Blasi, Kvar Black, Rui Tang, Matthew L Cooper, Kiran Vij, Ravi Vij, John Dipersio, Monica Shokeen, Samuel Achilefu

2020-Current year OA Pubs

No abstract provided.

Analysis Of A Human-Mediated Microbioinvasion: The Global Spread Of The Benthic Foraminifer Trochammina Hadai Uchio, 1962, Mary Mcgann, Maria Holzmann, Vincent M.P. Bouchet, Sibelle Trevisan Disaró, Patrícia P.B. Eichler, David W. Haig, Stephen J. Himson, Hiroshi Kitazato, Jean Charles Pavard, Irina Polovodova Asteman, André R. Rodrigues, Clément M. Tremblin, Masashi Tsuchiya, Mark Williams, Phoebe O'Brien, Josefin Asplund, Malou Axelsson, Thomas D. Lorenson

Research outputs 2022 to 2026

A non-indigenous species (NIS) of benthic foraminifera was first identified in a core collected in 1993 in San Francisco Bay, California, USA, and subsequently identified as Trochammina hadai Uchio, 1962. Archived samples and literature reviews were used to determine that the species, which is native to Asia, arrived in San Francisco Bay between the early 1960s and 1983. Through molecular analyses of specimens, archived samples and literature reviews from 1930-1983, and site surveys of harbors and estuaries along the western North American seaboard in 1994-2024, in total more than 2500 samples, we documented the presence of T. hadai at 73 …

Sagebrush, Wildfire, And Homeowners Associations: Climate Adaptation Opportunities In Summit County, Utah, Rebecca Ivans, Kendall Becker, Wesley Crump, J. Bradley Washa, Lewis Kogan, Scott Hotaling

All Current Publications

Environmental changes and rapidly expanding suburban developments are amplifying wildfire risk in Utah, including in mixed-sagebrush habitats like those in Morgan, Summit, and Wasatch counties along the Wasatch Back. Wildfire risk to people and structures is especially high in the wildland-urban interface (WUI), where homes and buildings intermingle with undeveloped wildlands and natural vegetation that can fuel wildfire. Much of this urban expansion is occurring in the form of large, dispersed developments managed by homeowners associations (HOAs), which often dictate standards for the homes and properties within their purview. Thus, HOAs can play a critical role in supporting wildfire mitigation …

The Next Frontier In The Study Of Noncovalent Bonding: Transition Metals, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

As work continues unabated in the study of noncovalent bonding, particularly σ-hole bonds, new challenges have emerged as the participation of transition metals in interactions of this sort is fast becoming appreciated. While there are certain similarities with the halogen, chalcogen, etc, bonds, in which the main group elements participate, there are certain unique properties of these metal atoms that must be analyzed before a complete understanding can be attained. As one example, these atoms tend to act simultaneously as both electron donors and acceptors, a synergistic action that amplifies the overall bond strength. Ideas are expressed in this paper …

The Onnagata: A Note Regarding The Male Actor Of Female Roles In Japanese Theatre, John M. Metcalf

The Ozark Historical Review

This paper discusses the influence of the Kabuki onnagata, male actors portraying female characters, on Japanese culture.

Positive Changes In Functional Capacity, Muscle Strength And Body Composition After Short Time Of Resistance Training Periodization In Older Women: A Quasi-Experimental Study, Ericles Vieira

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 949-970, 2025. We investigated the effects of a new approach with mixed session periodization resistance training (MSP) on functional performance, muscular strength, and body composition in older women. Twenty-one participants were tested before and after the intervention (10 weeks) and were allocated for convenience into two groups according to their available time; our schedule made two classes available, one at 6 a.m. (MSP), and one at 7 a.m. (active group-control). Results were analyzed through a mixed-model analysis with repeated measures. There was a group vs. time interaction for timed up and go (p < 0.001, η_{p …}

Person-Centered Trauma-Informed Care (Pctic): A Training Needs Assessment For Home And Community-Based Services In West Virginia, Ranjita Misra, A. Brianna Sheppard, Natalie Wilson, Megan C. Govindan, Matthew Myers, Amanda Acord-Vira, Steven Wheeler, Heather Henderson, Christena Ross, Laura Cooper, Rachel A. Goff

Journal of Appalachian Health

Introduction: Person-centered, trauma-informed care (PCTIC) is a combined, holistic service model promoting the well-being and empowerment of trauma survivors.

Purpose: This study examined the PCTIC knowledge, skills, and abilities needed by West Virginia (WV) Medicaid Home and Community-Based Services (HCBS) direct service professionals (DSPs) to serve clients that may have experienced trauma.

Methods: Semi-structured interviews were conducted with diverse stakeholders (n = 32) from 19 organizations that provide HCBS services in all 55 counties. Interviews focused on identifying current training, needs and knowledge gaps, and priority areas for additional PCTIC training. ATLAS.ti software was used to manage and code. Validity …

Collaborative Care Integration For Improving Outcomes With Type 2 Diabetes And Psychiatric Disease, Leslie S. Arceneaux, Karan Kverno

International Nursing Research Congress (INRC)

Psychiatric disorders and diabetes are problems that frequently overlap in psychiatric and primary care settings. Those patients with psychiatric disorders and/or social problems have a higher incidence of diabetes complications and poor outcomes (Knudsen, et al., 2022). Clinician awareness of the person's diabetes health with measures to identify and support them, may reduce their risk of developing complications of Type 2 Diabetes Mellitus (T2DM). The purpose of this presentation is to address early identification and interventions to prevent complications of T2DM, and the importance of collaboration with diabetic care specialists among patients receiving psychiatric care. Diabetes and psychiatric disorders can …

Essay On Dr. E. W. Stafford By James Franklin Buchanan, April 1968 And January 1991, James Franklin Buchanan

James Franklin “Frank” Buchanan Papers

This essay, written in two parts by James Franklin Buchanan, shares some biographical information and anecdotes on Biological Sciences professor, Dr. Ethelbert Withrow (E. W.) Stafford. The essay also includes some historical information about Mississippi State University as it was during Buchanan's time as a student there.

Autobiography, James Franklin Buchanan, February 10, 1974

James Franklin “Frank” Buchanan Papers

In this bound copy of James Franklin Buchanan's autobiography, he begins with a brief, two page description of his early life prior to enlisting with the Army . On page three he states that "This portion of my story deals with the army" and proceeds to document his time in the army from enlistment, through training, and on to his service overseas during World War II. Some photographs of people and places during Buchanan's time in the Army are included. Additionally, an account of his trip abroad d for the Farm Bureau Federation's Bavarian Adventure tour of Germany, Austria, and …

Valuing Fruit Tree Lease Contracts Under Uncertainty: A Probabilistic Framework For Fair Pricing, Abdurakhman Abdurakhman, Agus Sihabuddin, Kurniawan Chandra Wijaya, Evita Purnaningrum, Di Asih I Maruddani

Iraqi Journal for Computer Science and Mathematics

Fruit tree lease contracts are a prevalent economic practice in Indonesia, especially within rural communities. This study addresses the challenge of establishing equitable contract prices for both lessees and tree owners, specifically by integrating the inherent uncertainties associated with crop yield and fruit price fluctuations. To achieve this, we develop and employ two distinct models: Fixed-Time Discount Model (FTD) and the Dynamic-Time Discount Model (DTD). Each model is mathematically formulated, leveraging a Poisson distribution to capture yield uncertainty and a Uniform distribution to represent fruit price variability. Through computations, we evaluate the impact of key parameters - average yield ( …

Access Barriers To Early Childhood Development Surveillance And Screenings: Insights From Pediatric Office Providers, Pamela Russell Ledesma

Walden Dissertations and Doctoral Studies

Scholarly literature review found a gap in the identification of barriers experienced by pediatric office providers (POPs) for the provision of early childhood development (ECD) surveillance among culturally and linguistically diverse (CALD) children under the age of three years. The barriers may inhibit access to recommended screenings at defined milestones during the state of neurogenesis, whereby a child’s life trajectory may be negatively impacted and further handicap society at large. This qualitative study aimed to explore the access barriers and remedial strategies identified in the reconstructed narratives of southeast Florida POPs. The research design was premised on the behavioral model …

Analysis Of Antibody Affinity Maturation And Thermal Stability Of Proteins Using Photophysical Approaches, Claire Baxter

Dissertations

Engineered antibodies (Abs) have found applications in disparate fields such as enzyme catalysis and medicinal therapeutics because of their exquisite binding affinity and specificity. To engineer antibodies for these purposes, a firm understanding of the underlying mechanisms that control Ab affinity and specificity is needed, so these properties can be tightly controlled and adapted to the application at hand. My research characterized the binding site of the anti-fluorescein Ab 4-4-20 using an array of biophysical techniques and gives insight into the binding site interactions that give rise to both affinity and specificity. We utilized Fab fragments of the anti-fluorescein Ab …

Critical Constellations: The Second Premio Alambique, Dale Knickerbocker, Mary E. Ginway

Alambique. Revista académica de ciencia ficción y fantasía / Jornal acadêmico de ficção científica e fantasía

This article announces the winner of the second Premio Alambique, awarded by Alambique: Revista Académica de Ciencia Ficción y Fantasia / Jornal Acadêmico de Ficção Científica e Fantasía to the best academic books or monograph about science fiction and/or fantasy in the Hispanic and Luso-Brazilian worlds (including those in the U.S.), and offers a brief review of all submissions.

Advancing Ckd Diagnosis: Race-Free Egfr, Cystatin C, And Genetic Insights, Halah Tariq Albar

Saudi Toxicology Journal

Globally, the rates of chronic kidney disease (CKD) are increasing due to the increasing incidence of hypertension, obesity, and diabetes mellitus. Early detection and treatment of kidney disease are essential in improving health outcomes. Estimate glomerular filtration rate (eGFR) is used to diagnose, stage, and manage CKD. CKD biomarkers are broadly categorized into traditional (serum creatinine), emerging (cystatin C), and disease specific (Interleukin-6). The purpose of this narrative review is to synthesize the current evidence regarding the use of eGFR in diverse populations. The initial eGFR equations included race variables, which created a controversial debate about their relevancy and has …

Re: Butte Priority Soils Operable Unit (Bpsou) Final Reclamation Improvement Sites Field Sampling And Investigation Plan (Fsp): Bres No. 18 – Walkerville Ballfield, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

More Than Trauma: The Story Of Intergenerational Survival, Tiffany Fang

Dissertations

Parental trauma can have a profound effect on children. The process of passing along traumatic experiences, known as the intergenerational transmission of trauma (IGT) and the process of passing along adaptations to these adverse circumstances, known as the intergenerational transmission of resilience (IGR), have been explored in populations such as survivors of the Holocaust and war refugees (Danieli et al., 2017; Kellermann, 2001; Sangalang & Vang, 2017). This study sought to extend findings to Chinese American immigrant families, many of whom experienced trauma in the form of war, sociopolitical violence, and poverty in 20th-century China. Despite the presence of these …

Adolescent Social Media Use And Complete Mental Health: Examining The Intersections Of Identity, Social-Emotional Skills, And Social Support, Reese Hyzer

Dissertations

Social media and technology use have become ubiquitous for today’s adolescents. With the rise in technology use, mental health disorder diagnoses have also increased. Despite the increase in concern for both adolescent social media use and mental health, many schools, parents, and youth service clinicians do not have the knowledge or resources to intervene effectively. The current study explores two research questions. The first is to evaluate the moderating effect of social-emotional skills and social support on the relationship between social media use and mental health through structural equation modeling (SEM). The second research question is to explore whether this …

Upper Gastrointestinal Symptoms And Gulf War Illness In A Clinical Cohort Of Us Veterans: A Retrospective, Cross-Sectional Study, Abdelrahman Yousef, Sarah T Ahmed, Theresa H Nguyen Wenker, Alice B S Nono-Djotsa, Stephen H Boyle, Elizabeth J Gifford, Deeksha Malhotra, Helena Chandler, Sandhya Bandi, Drew A Helmer

Faculty, Staff and Students Publications

Objective: Approximately 30% of the 700 000 US Gulf War Veterans (GWVs) report symptoms collectively termed Gulf War Illness (GWI), a multisymptom illness of uncertain pathophysiology. Prior studies in GWI focus on overlap with irritable bowel syndrome. This study examines the associations between upper gastrointestinal (UGI) symptoms, GWI and specialty GI care.

Methods: This cross-sectional study analysed GWVs referred to a Veterans Health Administration clinical War-Related Illness and Injury Study Center (2008-2020). Symptoms, demographics, military service and clinical history were obtained from self-reported intake packets. GWI was defined by the Centers for Disease Control and Prevention criteria requiring moderate-to-severe symptoms …

Dynamical Regulation Of Blood Pressure And Cognitive Function, Joshua Sweigert, Tara Gruenewald, Margie Lachman, Teresa Seeman, Maxine Weinstein, Tse-Hwei Choo, Martina Pavlicova, Ramakrishna Mukkamala, Richard P. Sloan

Psychology Faculty Articles and Research

BACKGROUND

Blood pressure (BP) is not steady. It varies over intervals from months to consecutive cardiac cycles, and this variation contains meaningful information beyond mean BP. Variability over multiple clinic visits (VVV-BP) and during 24-h ambulatory monitoring (ABPV) is positively related to risk of stroke and coronary artery disease and negatively associated with cognitive performance. Beat-to-beat BP variation, often quantified as low frequency variability (0.04–0.15 Hz, LF-BPV), is less well-studied. Here, we examine the relationship between LF-BPV and cognitive outcomes in 1953 participants from the Midlife in the US study.

METHODS

Participants completed the Brief Test of Adult Cognition by …

Advances In Indole Chemistry: Regiodivergent Annulations And Bridged Azacycle Synthesis, Zachary Tihomir Protich

Dartmouth College Ph.D Dissertations

An important aspect for the research and development of new drug therapies is the ability to use modular synthetic methods to rapidly access structurally diverse drug-like building blocks. Nitrogen-containing heterocycles represent one of the most prevalent structural motifs found in pharmaceutical agents and biologically active natural products. However, despite their ubiquity, existing methods for accessing these structures often remain limited in scope, efficiency, and structural diversity, particularly when targeting densely functionalized or sterically demanding scaffolds from simple starting materials.

To address this problem, the research described in this dissertation focuses on the design and development of (3+2) annulation reactions for …