Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2025

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 3811 - 3840 of 31382

Full-Text Articles in Entire DC Network

Intelligent Decision-Making Systems In Smart Greenhouses, Muso Berdiyor Ugli Allanov Nov 2025

Intelligent Decision-Making Systems In Smart Greenhouses, Muso Berdiyor Ugli Allanov

Chemical Technology, Control and Management

Smart greenhouses offer a solution to sustainable food production under climate uncertainty, yet their management often depends on fixed rules or human intuition. This study proposes an intelligent decision-making framework that integrates optimization, simulation, and a neural set into a self-learning system. By generating “conditionally real data” through simulation and evolutionary algorithms, the system can predict microclimatic changes and optimize control of water, energy, and nutrients. Continuous digital feedback enables adaptive, data-efficient operation even with limited real data. Experimental results demonstrate reduced resource use and improved yield stability, advancing the development of autonomous and resilient greenhouse ecosystems.


Strengthening Thailand’S Ship-Sourced Oil Spill Management : A Comparative Analysis Of Legal And Response Frameworks In Thailand, The United States, And Singapore, Supranee Wattanapongsakul Nov 2025

Strengthening Thailand’S Ship-Sourced Oil Spill Management : A Comparative Analysis Of Legal And Response Frameworks In Thailand, The United States, And Singapore, Supranee Wattanapongsakul

World Maritime University Dissertations

No abstract provided.


Micronuclei As A Marker Of Genotoxicity In An Urban Songbird., Elise Mittlestat Nov 2025

Micronuclei As A Marker Of Genotoxicity In An Urban Songbird., Elise Mittlestat

College of Arts & Sciences Senior Theses

A rise in industry and vehicle emissions in the last 20 years has led to an increase in exposure to air pollution. Air pollution has been identified as a major threat to both human and animal health and it has been linked to elevated oxidative stress. One of the most severe consequences of oxidative stress is genotoxic damage. Birds have been identified as promising sentinels for human health, but the effects of air pollution on genotoxicity in birds is understudied. In this study, I evaluated the association between air pollution and markers of genotoxicity in American Robins (Turdus migratorius) to …


Odor Concentration Matters: How Odor Concentration Guides Consummatory Behavior And Formation Of Odor-Taste Associations In Rats, Dinna N. Ferreira Nov 2025

Odor Concentration Matters: How Odor Concentration Guides Consummatory Behavior And Formation Of Odor-Taste Associations In Rats, Dinna N. Ferreira

College of Arts & Sciences Senior Theses

Taste concentration is a key determinant of palatability. For example, higher concentrations of sucrose, a sweet taste, are typically preferred to lower ones, whereas the opposite is true for citric acid, a sour taste. Yet taste is not the only determinant of food preference. Flavor arises from the integration of taste and olfactory cues, and repeated exposure to odor-taste combinations can lead odors to acquire the hedonic value of their associated taste. However, the contribution of odor concentration, independent of taste, in guiding consummatory behavior is not well understood.

To address this, we conducted two experiments using a two-bottle brief-access …


Investigating The Effect Of Kcl Stress In Raphanus Sativus, Stephanie N. Nelms, Mason Oelke, Luke Cantu, Amanda Munoz, Gisel Cardenas, Grace Cogswell, Tatum Simms, Aniruddha Acharya Nov 2025

Investigating The Effect Of Kcl Stress In Raphanus Sativus, Stephanie N. Nelms, Mason Oelke, Luke Cantu, Amanda Munoz, Gisel Cardenas, Grace Cogswell, Tatum Simms, Aniruddha Acharya

Undergraduate Research

Presented by Stephanie Nelms at the Arkansas INBRE Conference on November 7-8, 2025.


Fisheries Research Report No. 355: Recreational Fishing For Western Rock Lobster In 2024/25: Estimates Of Participation, Effort And Catch, Claire B. Smallwood, Karina L. Ryan, Alissa Tate Nov 2025

Fisheries Research Report No. 355: Recreational Fishing For Western Rock Lobster In 2024/25: Estimates Of Participation, Effort And Catch, Claire B. Smallwood, Karina L. Ryan, Alissa Tate

Fisheries Research Reports

The Western Rock Lobster (WRL) (Panulirus cygnus) is the most commonly caught Rock Lobster (RL) species in Australia. Catches from the commercial and recreational sectors are required to determine and monitor Total Allowable Commercial Catch (TACC), Total Allowable Recreational Catch (TARC) and the proportion of Allowable Harvest Level (AHL) achieved. The TARC is evaluated annually based on a 5-year average.

Data for the recreational sector are obtained using phone-recall surveys to provide annual estimates of participation, fishing effort and retained catch (by numbers) from recreational fishers who hold a RL licence. Average weight, obtained from boat ramp surveys, are used …


A Cross-National Study Of Female Fertility Intention And Family Welfare Policies In China And South Korea, Jingshuang Gao Nov 2025

A Cross-National Study Of Female Fertility Intention And Family Welfare Policies In China And South Korea, Jingshuang Gao

SOC 605 Comparative Social Policy Research Project - Student Works

Against the backdrop of chronically low fertility rates in China and South Korea, this study investigates the relationship between female fertility intentions and family welfare policies in these two East Asian societies. It aims to identify the multidimensional challenges women face, analyze the disjuncture between existing fertility support policies and women's fundamental needs, and propose pathways for policy optimization. Employing a mixed-methods approach including online observation, critical discourse analysis of policy texts, and small-scale semi-structured interviews, the research reveals that women's fertility intentions are constrained by physiological risks, economic pressures, the cultural expectations of "motherhood," and conflicts with personal development. …


Balancing Act: Addressing Child Quantity-Quality Trade-Off In The Philippine Households With Educational And Health Social Programs, John Andrew A. Alsol, Marie Carroline Magante Nov 2025

Balancing Act: Addressing Child Quantity-Quality Trade-Off In The Philippine Households With Educational And Health Social Programs, John Andrew A. Alsol, Marie Carroline Magante

Economics Department Faculty Publications

The child quantity-quality (CQQ) trade-off has been extensively studied in economic research since it was first introduced by Becker and Lewis in 1973. Studies have argued that the current economic circumstances and the presence of government aid in education and health determine the existence and extent of the CQQ trade-off. However, there is a dearth of empirically tested research on the possible decreasing effects of social programs on the CQQ trade-off. Using the 2019 Annual Poverty Indicators Survey, this paper seeks to determine the effect of education and health social programs on the CQQ trade-off in the Philippines. Probit models …


The Plymouth County Comfort Dogs Program: Fostering Resiliency, Academic Success, And Relationships With Law Enforcement, Leslie J. Sattler, Robert Mcmackin, Chloe Wojtowicz Nov 2025

The Plymouth County Comfort Dogs Program: Fostering Resiliency, Academic Success, And Relationships With Law Enforcement, Leslie J. Sattler, Robert Mcmackin, Chloe Wojtowicz

Bridgewater Review

As most dog owners will tell you, there is something special about interacting with a dog. They seem to know when we need them, whether it’s because we’re stressed, sad, or simply need an emotional boost. The rise of private individuals and professional agencies offering canine-specific animal-assisted interventions attests to these unique dog qualities. One such provider is the Plymouth County District Attorney’s Office, which administers the Plymouth County Comfort Dogs Program (PCCDP), a network of handler-dog teams.


Championing Faculty Scholarship And Community: Writing Across The Curriculum (Wac) Summer Institute 2025, Jonathon Shirland, John Mulrooney, Elizabeth Veisz Nov 2025

Championing Faculty Scholarship And Community: Writing Across The Curriculum (Wac) Summer Institute 2025, Jonathon Shirland, John Mulrooney, Elizabeth Veisz

Bridgewater Review

For one week in August, participants from academic departments across campus come together at the WAC Summer Institute to advance their own projects in a collegial environment of exchange, community, and mutual accountability. For eighteen years, WAC has played this vital role in supporting BSU faculty in their scholarly and creative endeavors. Small working groups facilitated by a WAC Coordinator commit to alternating focused periods of writing with peer review and discussion, with the aim of significantly advancing projects towards publication.


Living Shoreline Prioritization And Hydrodynamic Habitat Suitability Models For Restoration In The Indian River Lagoon And Lake Worth Lagoon, Florida, Kelly M. Kibler, Melinda J. Donnelly, Vincent Encomio, Madison Giuntoli, Manisha Thenuwara, Brice Bennett, Laura Andrade Barron, Mariam Sonbol, Wynter Raine Seppala, Namritha Ramakrishnan, Jennifer Jordan Báez, Beth Orlando, Irene Arpayoglou, Melissa Meisenburg Nov 2025

Living Shoreline Prioritization And Hydrodynamic Habitat Suitability Models For Restoration In The Indian River Lagoon And Lake Worth Lagoon, Florida, Kelly M. Kibler, Melinda J. Donnelly, Vincent Encomio, Madison Giuntoli, Manisha Thenuwara, Brice Bennett, Laura Andrade Barron, Mariam Sonbol, Wynter Raine Seppala, Namritha Ramakrishnan, Jennifer Jordan Báez, Beth Orlando, Irene Arpayoglou, Melissa Meisenburg

Indian River Lagoon Shorelines

The spatial dataset: UCF_shorelinemodel_IRL_LWL.shp, was created with support from the Indian River Lagoon National Estuaries Program and Florida Sea Grant. These projects cumulatively led to creation of a living shoreline restoration prioritization model and hydrodynamic habitat suitability models for 1,550 km (963 miles) of estuarine shorelines in Indian River Lagoon and Lake Worth Lagoon.

The dataset presented herein includes:

  1. shoreline data from >15,000 transects collected in the field,
  2. shoreline wave climate data created through hydrodynamic modeling and frequency analysis of historic data,
  3. categorization of potential risk for shoreline boat wake impact,
  4. persistence of seagrass within 210 m of the shoreline, …


The Effects Of Head Injury On Executive Function And Emotion Regulation In Male And Female Athletes, Anna Christine Speer Nov 2025

The Effects Of Head Injury On Executive Function And Emotion Regulation In Male And Female Athletes, Anna Christine Speer

Doctor of Psychology (PsyD)

Head injuries are a common occurrence among athletes, and research on concussions has seen significant rise alongside an increasing awareness of their symptoms and effects. Women’s involvement in sports has also rapidly increased in recent decades. However, a significant gap in research exists as to how the effects of head injuries may differ across sexes, particularly regarding executive function and emotion regulation. This study aimed to bridge this gap in research by investigating how the frequency of head injuries in both female and male athletes impact executive functioning and emotion regulation among current and former athletes. Current and former athletes …


A Word From The Writing Team (November 2025), Pam Walter, Mfa, Laura Deloretta, Phd Nov 2025

A Word From The Writing Team (November 2025), Pam Walter, Mfa, Laura Deloretta, Phd

A Word From the Writing Team (Newsletter)

No abstract provided.


2025 November, Morehead State University. Office Of Communications & Marketing. Nov 2025

2025 November, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for November of 2025.


‘Earth System Engineers’ And The Cumulative Impact Of Organisms In Deep Time, S. A. F. Darroch, M. M. Casey, A. T. Cribb, A. E. Bates, M. E. Clapham, D. L. Contreras, M. Craffey, I. A. P. Duijnstee, W. Gearty, N. J. Gotelli, M. J. Hamilton, R. F. Hayes, P. M. Hull, D. E. Ibarra, V. A. Korasidis, J. Lee, C. V. Looy, T. R. Lyson, B. Muddiman, P. D. Roopnarine, A. B. Shupinski, F. A. Smith, A. L. Stigall, C. P. Tomé, K. A. Turk, A. Villaseñor, P. J. Wagner, Steve C. Wang Nov 2025

‘Earth System Engineers’ And The Cumulative Impact Of Organisms In Deep Time, S. A. F. Darroch, M. M. Casey, A. T. Cribb, A. E. Bates, M. E. Clapham, D. L. Contreras, M. Craffey, I. A. P. Duijnstee, W. Gearty, N. J. Gotelli, M. J. Hamilton, R. F. Hayes, P. M. Hull, D. E. Ibarra, V. A. Korasidis, J. Lee, C. V. Looy, T. R. Lyson, B. Muddiman, P. D. Roopnarine, A. B. Shupinski, F. A. Smith, A. L. Stigall, C. P. Tomé, K. A. Turk, A. Villaseñor, P. J. Wagner, Steve C. Wang

Mathematics & Statistics Faculty Works

Understanding the role of humans as ‘ecosystem engineers’ requires a deep-time perspective rooted in evolutionary history and the fossil record. However, no conceptual framework exists for studying the rise of ecosystem engineering in deep time, requiring us to consider effects that fall outside the scope of traditional definitions. Here, we present a new framework applicable to both modern and ancient engineering-type effects. We propose a new term – ‘Earth system engineering’ – to describe biological processes that alter the structure and function of planetary spheres, and which combines core tenets of ecosystem engineering, niche construction, and legacy effects. We illustrate …


Biosecurity Council Of Western Australia Annual Report 2024-25, Department Of Primary Industries And Regional Development, Western Australia Nov 2025

Biosecurity Council Of Western Australia Annual Report 2024-25, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

Established in 2008, the Biosecurity Council of Western Australia (Council) is a specialist advisory group to the Minister for Agriculture and Food (Minister), the Hon Jackie Jarvis MLC and Director General (DG) of Department of Primary Industries and Regional Development (DPIRD).

The Council operates at a strategic level, with a long-term vision for effective biosecurity in Western Australia (WA) for the protection of WA’s environment, agriculture and aquaculture industries, social amenity, and economic development.

Matters the Council may provide advice on include, but are not limited to:

• the requirements of a comprehensive and effective biosecurity system for WA

• …


Dean's Research Newsletter, November 2025, Neil W. Schluger Nov 2025

Dean's Research Newsletter, November 2025, Neil W. Schluger

SOM Dean's Research Newsletter

No abstract provided.


Impact Of Resilience On Emotional Intelligence & Burnout Among Academicians: A Mediation Study, Shwati Sudha, Shrejal Kumari, Govind Swaroop Pathak Nov 2025

Impact Of Resilience On Emotional Intelligence & Burnout Among Academicians: A Mediation Study, Shwati Sudha, Shrejal Kumari, Govind Swaroop Pathak

American Business Review

Resilience is examined as a mediator between emotional intelligence and burnout. The study also investigates the implications of emotional intelligence on burnout. An empirical investigation was conducted among 257 academicians employing purposive sampling. Primary data were obtained using a 5-point likert scale, incorporating validated tools, including the Maslach Burnout Inventory (MBI), Nicholson McBride Resilience Questionnaire (NMRQ), Mindful Attention Awareness Scale (MAAS), Self-Regulation Inventory (SRQ), Intrinsic Motivation Inventory (IMI), and Interpersonal Reactivity Index (IRI). The analysis was performed using Hayes (2018) SPSS Process Macro Model 4. Burnout was found as positively correlated with resilience and emotional intelligence, while emotional intelligence also …


Identifying Sex- And Gender-Specific Endocrinological, Lifestyle, Psychosocial, And Socio-Cultural Targets For Alzheimer's Disease Prevention In Africans: The Female Brain Health And Endocrine Research In Africa (Fember-Africa) Project, Chinedu Momoh, Benard Aliwa, Lukoye Atwoli, Karen Blackmon, Edna Bosire, Samuel Gitau, Harrison Kaleli, Ciru Kamanda, Linda Khakali, Rachel Maina, Peter Mativo, Sylvia Mbugua, Zul Merali, Kendi Muchungi, Anne Njogu, Douglas Nyankira, Alice Ondieki, Catherine Onyancha, Stanely Onyango, Jasmit Shah, Sheena Shah, Cynthia Smith, Dilraj Sokhi, Sheila Waa, Thomas Thesen Nov 2025

Identifying Sex- And Gender-Specific Endocrinological, Lifestyle, Psychosocial, And Socio-Cultural Targets For Alzheimer's Disease Prevention In Africans: The Female Brain Health And Endocrine Research In Africa (Fember-Africa) Project, Chinedu Momoh, Benard Aliwa, Lukoye Atwoli, Karen Blackmon, Edna Bosire, Samuel Gitau, Harrison Kaleli, Ciru Kamanda, Linda Khakali, Rachel Maina, Peter Mativo, Sylvia Mbugua, Zul Merali, Kendi Muchungi, Anne Njogu, Douglas Nyankira, Alice Ondieki, Catherine Onyancha, Stanely Onyango, Jasmit Shah, Sheena Shah, Cynthia Smith, Dilraj Sokhi, Sheila Waa, Thomas Thesen

Brain and Mind Institute

Dementia rates are rising globally, with the burden increasing most rapidly in low- tomiddle-income countries. Despite this, research into Alzheimer’s disease and relateddementias (ADRD) among African populations remains limited, with existing modelsbased on Western cohorts that overlook sex-, gender-, and ancestry-specific factors.The Female Brain Health and Endocrine Research in Africa (FemBER-Africa) project,hosted at the Brain and Mind Institute, Aga Khan University, Kenya, will establish adeeply phenotyped cohort of 250 African individuals across the ADRD spectrum. Itwill assess sex-specific risk factors linked to ethnicity, lifestyle, and endocrinologicalvariables using fluid-based biomarkers (blood and saliva), neuroimaging (magneticresonance imaging and positron emission tomography), and …


Pharmacy Matters November 2025, University Of Mississippi School Of Pharmacy Nov 2025

Pharmacy Matters November 2025, University Of Mississippi School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: $10 Million NIH Grant Fuels Next Chapter for UM Glycoscience Research, UM Pharmacy Alumna Appointed to National Immunization Advisory Committee, Inspiring the Next Generation: Fall Recruitment Recap, School of Pharmacy Featured in Oxford Economic Development Video, From OxfordRx to Alumni Leadership, Pharmacy Student Earns University Award for Expanding Access to Diabetes Care, Pharmacy Alumnus Creates New Scholarship Fund


Pesticides, Pollinators, And Producers: The Epa’S New Herbicide And Insecticide Strategies And Illinois Farmers, Jonathan Jerkatis Nov 2025

Pesticides, Pollinators, And Producers: The Epa’S New Herbicide And Insecticide Strategies And Illinois Farmers, Jonathan Jerkatis

Northern Illinois University Law Review

The Environmental Protection Agency (EPA) has introduced new herbicide and insecticide strategies to comply with the Endangered Species Act (ESA), a move that will have significant implications for Illinois farmers and endangered species. Illinois, a leading producer of corn and soybeans, relies heavily on pesticides. Unfortunately, these chemicals have been identified as a key driver of monarch and other endangered species population decline. This note examines how the EPA’s new strategies aim to balance species protection with agricultural viability, addressing concerns over financial burdens of compliance, the complexity of the strategies, and a lack of enforcement provisions. While Illinois farmers …


The Population History Of Central Europe In The Early Bronze Age (2200/2100–1600/1500 Bc) - A Craniometric Approach, Tamás Szeniczey, Eszter Melis, Július Jakab, Jozef Bátora, István Major, Mihály Molnár, Anikó Horváth, László Palcsu, Anett Gémes, Katalin Gyenesei, Hugo Reyes-Centeno, Viktória Kiss, Tamás Hajdu Nov 2025

The Population History Of Central Europe In The Early Bronze Age (2200/2100–1600/1500 Bc) - A Craniometric Approach, Tamás Szeniczey, Eszter Melis, Július Jakab, Jozef Bátora, István Major, Mihály Molnár, Anikó Horváth, László Palcsu, Anett Gémes, Katalin Gyenesei, Hugo Reyes-Centeno, Viktória Kiss, Tamás Hajdu

Anthropology Faculty Publications

During the Late Neolithic and Early Bronze Age, migrations and the advent of working bronze alloy materials triggered profound cultural, social, and economic shifts across Central Europe. As a result of this processes, many communities with distinct archaeological and cultural characteristics emerged during the Central European Early Bronze Age (between circa 2200/2100 and 1600/1500 BC) in Central Europe, and with the Middle Bronze Age of the Carpathian Basin (between 2000/1900 and 1500/1450 BC). This study examines the biological relationships among these populations through biodistance analyses, aiming to clarify connections between cultural and biological affinities within the emerging heterogeneous communities. Craniometric …


Degenerating Intervertebral Discs In The Streptozotocin-High-Fat Diet Model Of Type 2 Diabetes Show Extensive Inflammation, Christian E Gonzalez, Rachana S Vaidya, Sade W Clayton, Simon Y Tang Nov 2025

Degenerating Intervertebral Discs In The Streptozotocin-High-Fat Diet Model Of Type 2 Diabetes Show Extensive Inflammation, Christian E Gonzalez, Rachana S Vaidya, Sade W Clayton, Simon Y Tang

2020-Current year OA Pubs

The chronic inflammation observed during type 2 diabetes (T2D) is associated with spinal pathologies, including intervertebral disc (IVD) degeneration and chronic spine pain. Despite confounding factors, such as obesity, studies show that, after adjusting for age, body mass index and genetics (e.g. twins), patients with T2D experience disproportionate severity of IVD degeneration and/or back pain than individuals without T2D. We hypothesized that chronic T2D fosters a proinflammatory microenvironment within the IVD that promotes degeneration and disrupts homeostasis. To test this, we evaluated two common mouse models of T2D - leptin-receptor deficient (db/db) mice and mice with a chronic high-fat diet …


Assessing The Tumor Suppressive Impact And Regulatory Mechanisms Of Spdef Expression In Breast Cancer, Maansi Solanky, Maninder Khosla, Suresh K. Alahari Nov 2025

Assessing The Tumor Suppressive Impact And Regulatory Mechanisms Of Spdef Expression In Breast Cancer, Maansi Solanky, Maninder Khosla, Suresh K. Alahari

School of Graduate Studies Faculty Publications

Background/Objectives: Breast cancer is a heterogeneous disease, and the role of the transcription factor SPDEF remains controversial. We aimed to clarify the prognostic value of SPDEF, explore demographic and molecular correlates of its expression, and investigate potential regulatory mechanisms underlying its dysregulation. Methods: Genomic and clinical data for 1218 breast cancer tumors were obtained from The Cancer Genome Atlas (TCGA). SPDEF mRNA expression was compared across intrinsic subtypes, age, and race, and prognostic significance was evaluated by Kaplan–Meier analysis. Promoter methylation patterns and DNA methyltransferase (DNMT) expression were examined as potential regulatory drivers. Co-expression analysis was performed using gene panels …


Skrmetti Beyond Scrutiny, Kate Redburn Nov 2025

Skrmetti Beyond Scrutiny, Kate Redburn

Faculty Scholarship

In United States v. Skrmetti, the Supreme Court upheld Tennessee Senate Bill 1 (SB 1), a state law that prohibits transgender minors from accessing gender-affirming care. For the first time, the Court considered a fundamental question in civil rights law: How does the Fourteenth Amendment regard transgender people? The Court gave little guidance. It did not sort out principles for deciding when anti-transgender discrimination classifies by sex, nor whether transgender people are a suspect class. Instead, the Court held that “[i]n the medical context, the mere use of sex-based language does not sweep a statute within the reach of …


Trips And Its Futures, Peter K. Yu Nov 2025

Trips And Its Futures, Peter K. Yu

Faculty Scholarship

The Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS Agreement) was adopted on 15 April 1994, along with the estab-lishment of the World Trade Organization (WTO). With the WTO’s recent celebration of its thirtieth anniversary, it is high time we explore what the future will hold for this agreement. This chapter begins by revisiting the past to examine whether the TRIPS Agreement would be adopted if it were negotiated today. The chapter then discusses whether WTO members will undertake a major overhaul of this agreement in the future. Taking note of the fast-evolving international norm-setting environment and …


Assessing Health Behaviors As Predictors Of Psychological Resilience And Bmi In A National And Small Military College Sample, Kylie Blodgett, Rachele Pojednic Nov 2025

Assessing Health Behaviors As Predictors Of Psychological Resilience And Bmi In A National And Small Military College Sample, Kylie Blodgett, Rachele Pojednic

Research outputs 2022 to 2026

Highlights: What are the main findings? First-year students at a military college engage in more vigorous physical activity and strength training compared to a representative national sample. In the national sample, higher levels of physical activity, strength training, and better sleep are associated with greater psychological resilience and healthier BMI values and these associations were not observed in the military college students. What are the implication of the main findings? Promoting physical activity and adequate sleep may enhance resilience and support healthy body weight in civilian college populations. Military training may overshadow the influence of individual health behaviors on resilience …


Six Drivers Of Aging Identified Among Genes Differentially Expressed With Age, Ariella Coler-Reilly, Zachary Pincus, Erica L Scheller, Roberto Civitelli Nov 2025

Six Drivers Of Aging Identified Among Genes Differentially Expressed With Age, Ariella Coler-Reilly, Zachary Pincus, Erica L Scheller, Roberto Civitelli

2020-Current year OA Pubs

Many studies have compared gene expression in young and old samples to gain insights on aging, the primary risk factor for most chronic diseases. However, these studies only identify associations without distinguishing drivers of aging from compensatory geroprotective responses or incidental downstream effects. Here, we introduce a workflow to characterize causal effects of differentially expressed genes on lifespan. First, we performed a meta-analysis of 25 gene expression datasets comprising samples of various tissues from healthy, untreated adult mammals (humans, dogs, and rodents) at two distinct ages. Genes were ranked by the number of datasets in which they exhibited consistent differential …


The Role Of Fungal Proteases In Bioactive Peptide Production And Analytical Approaches For Tracking Their Activity, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsane Shiferaw Terefe, Michelle L. Colgrave Nov 2025

The Role Of Fungal Proteases In Bioactive Peptide Production And Analytical Approaches For Tracking Their Activity, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsane Shiferaw Terefe, Michelle L. Colgrave

Research outputs 2022 to 2026

Fungal proteases catalyse site-specific peptide bond cleavage in complex protein matrices, enabling bioactive peptide (BP) release. Accurate monitoring is vital for optimising hydrolysis efficiency, minimising nonspecific proteolysis, ensuring consistent yields, and preserving peptide biofunctionality. While analytical and computational tools are well-established for non-fungal systems, their adaptation to fungal proteases remains exploratory, with no comprehensive evaluation addressing the unique challenges in this field. This review synthesises current knowledge, identifies methodological gaps, and outlines future directions for developing fungi-specific analytical pipelines and computational frameworks for BP discovery. It explores fungal protease families, their roles in intracellular peptide processing, and fungal survival strategies. …


Plasma Biomarkers In Neuropsychiatric Syndromes: A Narrative Review, Zahinoor Ismail, Dylan X Guan, Ganesh Babulal, James Bateman, Marc Cantillon, Byron Creese, Fabrizia D'Antonio, Corinne Fischer, Jennifer Gatchel, Chinedu Momoh Nov 2025

Plasma Biomarkers In Neuropsychiatric Syndromes: A Narrative Review, Zahinoor Ismail, Dylan X Guan, Ganesh Babulal, James Bateman, Marc Cantillon, Byron Creese, Fabrizia D'Antonio, Corinne Fischer, Jennifer Gatchel, Chinedu Momoh

Brain and Mind Institute

Neuropsychiatric symptoms (NPS) are common features of neurodegenerative disease (NDD) but are relatively understudied compared to cognition, especially regarding biomarkers. Further, emerging evidence describes the utility of systematic assessment of NPS across the cognitive continuum, even in advance of dementia. In this narrative review, we discuss the role of plasma biomarkers in relation to NPS across the cognitive continuum of unimpaired, subjective cognitive decline, mild cognitive impairment, and dementia. While Alzheimer's disease is the primary focus, vascular, Lewy body, and frontotemporal dementia etiologies are also discussed. Literature searches included NPS and dementia-related search terms with additional literature identified based on …