Digital Commons Network^™

Exploring The Vitronectin Binding Affinity And Cell Viability Effect Of Small Molecule Metabolites From Medicinal Plants For Neuroblastoma, Stephenie C. A Alaribe, Sofia Granados-Aparici, Akolade R. Oladipupo, Isaac Vieco-Marti, Blessing E. Titilayo, Gordon Allen, Rosa Noguera

Pharmaceutical Sciences and Research

High-risk neuroblastoma (HR-NB) is an aggressive form of childhood cancer with a five-year survival rate of less than 50%, underscoring the need for more efficacious and less toxic treatments. The glycoprotein vitronectin (VN) has been linked to poor prognosis in patients with HR-NB, thus inhibitors of VN function represent a promising avenue for molecular mechanotherapy. This study investigated the binding affinity between the somatomedin B (SMB) domain of VN and natural compounds from the medicinal plant, Olax subscorpioidea, targeting the plasminogen activator inhibitor-1 (PAI-1). The therapeutic potential of α-amyrin (AMY), lupeol (LUP), and olax chalcone A (olax CHA) was tested …

Life As An Intern For Njit Stem For Success, Christopher Tava

STEM Month

I joined the STEM for Success Team in May 2023 with two main goals. The first goal was to reach 100 hours worth of contributions, as part of a mandatory internship requirement to graduate from the Academy for Mathematics, Science, & Engineering (AMSE). I reached that goal by early October 2023, although I have been motivated to continue my work with NJIT beyond that hour target. The second goal was to accomplish something that I was proud of with the resources that the New Jersey Institute of Technology (NJIT) provided me. I had heard of former students of AMSE that …

Genomic And Metabolic Network Characterization Of Fusarium Species, Hend Hussain Mueenuddin

Thesis/ Dissertation Defenses

Fusarium covers the wide genus of fungi with over 400 species that are key in agricultural and medical practice. The purpose of the current study was to perform a comprehensive genomic profiling of the 19 Fusarium species that were captured in the National Centre of Biotechnology Information (NCBI) database. The study was made to make a comparison of the data, based on the descriptive statistics of every species, with graphical representation images enabling clear demonstration of the numbers. The study indicated that the chromosomal numbers were in the range of 0-15, the gene count was roughly 11000 -19000, while that …

Chinese Communist Party Infiltration Of U.S. Pacific Islands: Protecting American National Security Through Defending Strategic Pacific Assets, Contessa Amedore

Liberty University Journal of Statesmanship & Public Policy

Many Americans picture the U.S.’s Western most border to be the coast of California. However, when threats have historically formed in the Pacific, U.S. Pacific Island territories have served as the nation’s first line of defense. Today, the Chinese Communist Party (CCP) have slowly but ambitiously deployed new age or ‘unrestricted’ warfare tactics against the United States and allies in their long awaited plan to assume global hegemony. Their illegal infiltration and psychological operations have gone past Taipei and reached American soil in Guam, the Northern Mariana Islands, and American Samoa. This paper examines how the (CCP) uses unrestricted warfare …

Potential Biomarkers Of Leptin And Insulin Resistance In Clinical-Subclinical Coronary Atherosclerosis And Related With Diabetes Mellitus In Male Patients: Cross-Section Study, Zeena Hussien Khudair, Abeer Cheaid Yousif Al-Fatlawi, Ahmed Qasim Jaafar Al-Haidari

Al-Ameed Journal for Medical Research and Health Sciences

Background Atherosclerosis is an inflammatory disease of the large arteries, a buildup of fatty plaque inside the arteries, leading to narrowing and hardening of the blood vessels. Objective: Find the relation of leptin and insulin resistance in clinical-subclinical coronary atherosclerosis and its relationship with diabetes mellitus. Material and Method: The cross-sectional study includes 90 males with a mean age of 33.00±6.131. They were used in the present study and divided into 45 patients with clinical coronary atherosclerosis, with a mean age of 34.500±4.949, and 45 patients with subclinical coronary atherosclerosis, with a mean age of 32.250±7.228, with ages ranging from …

Qpie Mathematics — Resonance Fields For Coherence: Defensive-Publication Abstract & Introduction, Teddy Burroughs

Defensive Publications Series

QPIE (Quantum Perspective Is Everything) extends the Streltsov–Singh–Dhar–Bera–Adesso (2015) program that operationally links quantum coherence and entanglement by introducing a triadic, time-explicit, and observer-inclusive information field. Where classical resource theory defines coherence as a static scalar derived from density matrices and bounded by monotonicity/convexity under incoherent operations, QPIE formalizes coherence as a dynamic resonance process among system (S), ancilla (A), and observer (O). The framework adds three core constructs: (i) observer-weighted monotonicity, admitting constructive feedback when the observer’s informational state aligns with the system; (ii) holo-convexity, which generalizes linear convexity to account for emergent cooperative order across ensembles; and (iii) …

Dual-Spectrum Multi-Layer Holographic Projection System With Shadow-Based Positional Sensing For Interactive Spatial Computing, Lorenzo Lbn Bernardini

Defensive Publications Series

The present invention discloses a revolutionary dual-spectrum multi-layer holographic projection system that fundamentally redefines the paradigm of human-computer spa- tial interaction by eliminating the necessity of wearable apparatus while simultaneously enabling tactile manipulation of volumetrically-rendered virtual objects. The system achieves this through an innovative architectural decoupling wherein visible-spectrum multi-projector arrays generate stratified holographic imagery across multiple depth planes, while a parallel infrared sensing subsystem performs continuous shadow-pattern analysis to extract precise three-dimensional positional information of the user within the interac- tion volume. This spectral bifurcation resolves the fundamental paradox inherent in prior art wherein projection and sensing mechanisms interfere through …

Unearthing The Undead Prejudice: How ‘Feminist Science’ Creates A More Empirically Accurate Scientific Framework By Revealing The Inherent Bias In All Investigate Methodologies, Horatio Holloway

Episteme

No abstract provided.

Superintelligence And The Burden Of Intelligence: A Zapffean Critique Of Ai, James (Xiaolong) Wang

Episteme

No abstract provided.

Protecting Particularity: An Ecumenical Theory Of Gender, Taika Sorensen

Episteme

No abstract provided.

Episteme Vol. 36

Episteme

No abstract provided.

Evaluating Igf1 And Igf1-R Levels As Risk-Related Indicators And Early Detection Tools In Estrogen Receptor–Positive Breast Cancer, Randa M. Lua’I, Khawla A. Kasar, Marwa A. Hassan

AUIQ Technical Engineering Science

Breast cancer (BC) remains one of the most common malignancies in women, with its development strongly influenced by hormonal and growth factor signaling. The insulin-like growth factor 1 (IGF1) and its receptor (IGF1-R) are increasingly recognized as key contributors to breast carcinogenesis, particularly in relation to estrogen receptor (ER) status. This study aimed to evaluate circulating IGF1 and IGF1-R levels among Iraqi women with BC and to explore their diagnostic and biological relevance. A total of 90 participants were enrolled, including 65 patients with histologically confirmed BC (41 ER-positive and 24 ER-negative) and 25 healthy controls. Serum concentrations of IGF1 …

Cv: Philip Blankenship (Behavioral Neuroscience), Philip Blankenship

Psychology Department Faculty Curricula Vitae

No abstract provided.

Spatial Patterns Of Salamander Density Across Human Disturbance Gradients In Warner Parks​, Siobhan M. Day

Science University Research Symposium (SURS)

Amphibians are sensitive to anthropogenic disturbance, making them valuable indicators of recreational impacts in urban parks. This study examines salamander occurrence across five research sites within Warner Parks, Nashville, Tennessee, which differ in trail density and foot traffic intensity. Salamander observations were compiled from two sources: field surveys conducted in Summer 2025 and iNaturalist records spanning the past 10 years. For spatial analysis, each site was defined by a 200 m radius buffer to include local habitat, and trail networks were further buffered at 10 m, 25 m, and 50 m to quantify salamander occurrence relative to trail proximity using …

Cv: Young "Paul" Kim (Computer Engineering), Young "Paul" Kim

ECaMS Department Faculty Curricula Vitae

No abstract provided.

The Lived Experiences Of Imposter Syndrome Among Women Of Color Professors In Higher Education, Adrianna Marie Hooker

Walden Dissertations and Doctoral Studies

This qualitative phenomenological study explored the unique challenges faced by women of color professors in higher education, who often experience imposter syndrome due to systemic barriers and underrepresentation. The purpose of this study was to gain an in-depth understanding of how these professors experienced and made meaning of imposter syndrome in academic settings. The central research question examined the meaning of imposter syndrome among women of color professors in higher education. This study was grounded in intersectionality and self-determination theory, which provided frameworks for understanding how multiple identities influenced feelings of inadequacy and professional identity. Participants included 12 women of …

Exploring Counselor Perspectives On The Role Of Ecotherapy In Mental Health Treatment: A Qualitative Study, Kimberly Seid

Walden Dissertations and Doctoral Studies

This grounded qualitative study explored the common themes of ecotherapy in practice. The research problem was the limited understanding of how counselors implement ecotherapy in clinical practice, hindering the field’s ability to fully integrate nature-based approaches into mental health treatment. The purpose of this grounded theory study was to explore counselor perspectives on ecotherapy using the biophilia hypothesis and Swarbrick’s wellness model. The research questions focused on how licensed mental health counselors understood, implemented, and evaluated the impact of ecotherapy. Qualitative data were collected through an online survey with open-ended questions from 15 licensed counselors across the United States who …

“Home.”: A Trauma-Informed Children’S Book Exploring Secure Attachment For Children In Foster Care, Keeli Langford

Undergraduate Theses

Estimates suggest 6% of U.S. children (nearly half a million) will be placed in foster care at any point between their birth and eighteenth birthday (Turney & Wildeman, 2017). This population of children is subject to multiple adverse childhood experiences (ACEs; Turney & Wildeman, 2017). Such ACEs include parental divorce, parental incarceration, parental abuse, a household member with a psychological disorder, violence exposure, or a household member grappling with substance use. Exposure to childhood ACEs can negatively affect children behaviorally, emotionally, socially, and academically (Lawrence et al., 2006; McGuire et al., 2021). Research indicates youth in foster care are more …

The Web Of Tpd Reform: A Reflective Tool For Analyzing And Improving Teaching Professional Development Programs For Teaching Assistants, Adam J. Chouinard, Diyala S. Shihadih, Star W. Lee, Stephanie J. Gutzler, Kaleb K. Heinrich, Mitra Asgari, Erin Shortlidge

Biology Faculty Publications and Presentations

Teaching assistants (TAs) play a pivotal role in the teaching mission of higher education, but too often they are asked to do this important job without adequate teaching professional development (TPD). By receiving training in inclusive and evidence-based teaching practices, TAs can in turn help disseminate effective teaching methods for the benefit of students throughout the nation; as future faculty, TPD also better prepares TAs for their careers, helps solve longstanding problems of inclusion and retention in STEM, and reforms disciplinary educational norms through cultural evolution. Thanks to prior research and advocacy efforts, there is a growing awareness that STEM …

Cardiac Sr-Mitochondria Contacts-Impact On Cardiac Physiology And Mitochondrial Fitness, Celia Fernandez-Sanz, Shey-Shing Sheu, Sergio De La Fuente

Center for Translational Medicine Faculty Papers

In adult cardiomyocytes, within the Mitochondrial Associated Membranes (MAMs), the sarcoplasmic reticulum (SR) and mitochondria juxtapose each other, forming a unique and highly repetitive functional structure throughout the cells. These SR-mitochondria contact sites have emerged as critical structures that regulate various physiological processes, including lipid exchange, calcium (Ca²⁺) communication, control of excitation-contraction bioenergetics coupling, and reactive oxygen species (ROS) production. Over the years, several scientific studies have reported the accumulation of diverse proteins within these SR-mitochondria close contacts. Some proteins strategically accumulate in these areas to enhance their function, such as the mitochondrial Ca²⁺ uniporter, while others …

The Impact Of Microaggression Exposure On Emotional Reactivity And Distress Following An Emotionally Provocative Movie Scene, Gwendolyn Jefferson

Walden Dissertations and Doctoral Studies

This quantitative study explored how past experiences with racial microaggressions affect emotional reactions to racially charged media and whether factors like age and gender influence that response. Using Minority Stress Theory as a guide, 183 African American adults completed the Racial and Ethnic Microaggressions Scale and the State-Trait Anxiety Inventory before and after watching a racially provocative film clip. The first analysis found no direct link between microaggression exposure and emotional change. However, further testing with analysis of variance showed that people with higher exposure reported much stronger emotional distress than those with lower exposure, F(1,180) = 38.12, p < .001, η² = .175. When demographic factors were added in a hierarchical regression, the model became significant, F(7,175) = 2.06, p = .036, R² = .076, showing that age (β = .086, p = .009) and gender (β = 1.505, p = .039) influenced emotional responses. Thus, older African American women showed the strongest distress, suggesting that the combined effects of race, gender, and age increase vulnerability to racial stress. These findings support the idea that racial trauma is complex and shaped by overlapping social identities. The study highlights the need for culturally sensitive mental health support, inclusive media portrayals, and greater awareness of generational and caregiving stress among African American women. By showing how overlapping identities shape emotional well-being, this research advances social change through empathy, reduced stigma, and institutional accountability, encouraging equity-driven practices that foster racial healing, fairness, and psychological resilience across communities.

Geneseo Authors Celebration 2025, Milne Library

Geneseo Authors Celebration

Milne Library began a tradition of celebrating faculty authorship in 2009 with a series of workshops and a celebration in collaboration with the Teaching and Learning Center. Over the years it has evolved to more accurately reflect on the variety of academic and creative work done here at Geneseo. The annual Geneseo Authors Celebration is an opportunity for the Library and the campus to celebrate the faculty and truly acknowledge the time and effort that faculty have invested into creating exceptional works that contribute to the scholarly discussions taking place in their disciplines.

Books authored or edited by Geneseo faculty …

Hepatic Ischemia-Reperfusion Injury: Underlying Mechanisms And Concepts In Liver Surgery And Liver Transplantation, Jie Zhao, Lidan Hou, Kenneth J Dery, Xiaoyi Yuan, Kang Ho Kim, Jerzy W Kupiec-Weglinski, David R Hall, Caitlin J Thornley, Mark J Hobeika, Holger K Eltzschig, Cynthia Ju

Faculty, Staff and Student Publications

Hepatic ischemia-reperfusion injury (H-IRI) is a critical complication in liver surgery and liver transplantation, contributing to graft dysfunction and poor clinical outcomes. When hepatocyte protective mechanisms are insufficient to counteract energy depletion and oxidative stress during ischemia, cell death occurs. Tissue damage during H-IRI leads to the release of damage-associated molecular patterns (DAMPs), which recruit and activate immune cells such as neutrophils and monocytes, orchestrating the initiation, progression, and eventual resolution of sterile inflammation. Extended criteria donor (ECD) livers, particularly steatotic ones, are more vulnerable to H-IRI, leading to poorer outcomes and limiting expansion of the donor pool. However, the …

Reprogramming Tumor Microenvironment Via Systemic Delivery Of Tlr3 Agonist And Manganese Nanoparticle, Young Seok Cho, Xingwu Zhou, Xiaoqi Sun, Ziye Wan, Julia Crowther, Mariko Takahashi, Swetha Kodamasimham, Qi Wu, May Thazin Phoo, Youngseo Na, Kai Han, Zaiye Li, Anna Schwendeman, Steven P Schwendeman, Yu Leo Lei, James J Moon

Faculty, Staff and Student Publications

Toll-like receptor (TLR) agonists, as potent immunostimulatory adjuvants, play a critical role in linking the innate and adaptive immune responses. However, their antitumor effects as cancer immunotherapeutic agents have been limited. Here, we report our finding that manganese ion (Mn2+) potentiates various TLR agonists, leading to robust activation of the TLR pathway and the stimulator of interferon genes (STING) pathway among innate immune cells. In particular, we have observed robust antitumor efficacy after intratumoral administration of a TLR3 agonist and Mn2+. To achieve systemic codelivery of TLR3 agonist and Mn2+, we have developed a low-molecular-weight poly(inosinic:cytidylic acid)-Mn2+ coordination lipid nanoparticle …

Cerebral Malaria And Multi-Organ Dysfunction Caused By Plasmodium Vivax In An Adult: A Case From Oman With A Literature Review, Saba M. Al Kindi, Shabnam Chhetri, Zahrah Z. Al Aamri, Suchata D. Dhuri, Zakariya Y. Al Balushi, Faryal Khamis

Sultan Qaboos University Medical Journal

Cerebral malaria is a life-threatening complication most commonly associated with Plasmodium falciparum. To the best of the authors’ knowledge, this is the first documented case in Oman of a previously healthy 38-year-old Pakistani male who presented to the Emergency Department of a tertiary care hospital in 2025 with cerebral malaria and multi-organ dysfunction syndrome (MODS) caused by Plasmodium vivax, confirmed by peripheral blood smear and polymerase chain reaction (PCR). The patient was treated with intravenous (IV) artesunate and supportive intensive care, resulting in full neurological recovery. This case highlights the importance of considering P. vivax as a potential …

Epigenetic Landscape In Lysosomal Storage Disorders: Mechanisms And Modulation, Andrés Felipe Leal, Harry Pachajoa, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Lysosomal storage disorders (LSDs) are rare substrate-accumulating diseases primarily characterized by mutations in genes encoding proteins involved in lysosomal function, most of which have enzymatic activity. Resulting lysosomal dysfunction leads to the overaccumulation of non- or partially degraded substrates. While it is true that enzyme deficiency is the primary cause of LSDs, the epigenetic alterations in DNA methylation, miRNA expression, and histone modifications appear to be critical mechanisms involved in the pathogenesis of LSDs. As epigenetic marks are, in most cases, reversible, their study becomes vital to developing strategies aimed at reversing epigenome alterations. Although classical therapeutic alternatives aim to …

Postmortem Vitreous Humor As An Alternative Matrix To Peripheral Blood For Benzodiazepine Detection, Sara Bussey

Honors Theses

Benzodiazepines are commonly prescribed secondary drugs of abuse that cause Central Nervous System depression through the neurotransmitter gamma aminobutyric acid. While not commonly fatal on their own, benzodiazepines have a minor risk for physical dependence and abuse. They also can have cumulative effects with other medications that can lead to overdose situations; thus, they are considered secondary drugs of abuse. While peripheral blood is considered the standard for xenobiotic detection in postmortem forensic toxicology, it is important to consider the validity of alternative matrices that could be analyzed in the event that blood was not available due to circumstances like …

Hydration Strategies In Ultra-Endurance Running: A Narrative Review Of Programmed Versus Thirst-Driven Approaches, Shawn C. Wierick, Rosie I. Perez, Xiujing Zhao, Brendon P. Mcdermott

Health, Human Performance and Recreation Faculty Publications and Presentations

Background/Objectives: Ultra-endurance running (UER) presents unique hydration challenges due to prolonged duration, variable terrain, environmental extremes, and gastrointestinal limitations. Athletes often use either programmed fluid intake (PFI), which prescribes fluid volumes based on estimated sweat rate, or thirst-driven fluid intake (TDFI), which relies on internal cues. This review examines the effectiveness and limitations of each strategy in the context of UER performance and safety. Methods: A narrative review was conducted using a targeted selection of peer-reviewed studies. Both laboratory- and field-based research were included to evaluate the physiological rationale, practical feasibility, and outcomes associated with PFI and TDFI. A total …

Association Between Adherence Barriers, Self-Reported Adherence, And Psychiatric Symptoms Among Adults With Bipolar Disorder, Martha Sajatovic, Jennifer B. Levin, Clara Adeniyi, Jessica Black, Celeste Weise, Nicole Fiorelli, Erika Kelley

Faculty Scholarship

Aims: While suboptimal medication adherence is a widely recognized problem for people with bipolar disorder (BD), it is less clear how individual characteristics are associated with varying levels of adherence and how specific adherence barriers impact behaviors. This interim analysis from an ongoing randomized controlled trial (RCT) examined associations between patient-reported adherence, adherence barriers, and mood symptoms among poorly adherent individuals with BD. Methods: RCT participants were adults age ≥ 18 years old with BD Type 1 or 2, difficulties with medication adherence, and actively symptomatic as measured by Brief Psychiatric Rating Scale (BPRS) score ≥ 36, Young Mania Rating …

Expression Of Dementia Biomarkers In Appalachian And Non-Appalachian Elvo Patients During Thrombectomy, Neha Anil, Christopher J. Mclouth, Hunter S. Hazelwood, Elise Dahlke, Jacqueline A. Frank, Nathan Millson, Mais Al-Kawaz, Jordan P. Harp, Will Cranford, Shivani Pahwa, David Dornbos Iii, Justin F. Fraser, Keith R. Pennypacker

University Faculty Publications and Creative Works

Vascular Cognitive Impairment and Dementia (VCID) affects 25-30% of stroke patients and includes cognitive impairments caused by vascular injury, such as post-stroke dementia. Rehabilitation has the potential to improve the quality of life for patients at risk of developing dementia. However, there is currently no reliable method to identify those at risk of dementia after a stroke. Several biomarkers, including ADRD (Alzheimer’s disease and related dementias) biomarkers (Ab, tau, NfL, and GFAP) and angiogenic factors (VEGF, Flt-1, Tie-2, PIGF, and FGF) have been associated with the development of dementia. Populations in Appalachia experience a higher incidence of stroke and related …