Digital Commons Network^™

Real-World Outcomes Of Infections Following Tisagenlecleucel In Patients With B-Cell All: A Cibmtr Analysis, Hemalatha G Rangarajan, Prakash Satwani, Megan M Herr, Min Chen, Michael J Martens, Kitsada Wudhikarn, Samuel John, Vanessa A Fabrizio, Emily M Hsieh, Amar H Kelkar, Erin Doherty, David I Marks, Olle Ringden, Brian Friend, Matthew S Kelly, Nosha Farhadfar, Tim Prestidge, Nasheed M Hossain, Hongtao Liu, Shahrukh Hashmi, Dipenkumar Modi, Lena E Winestone, Zeinab El Boghdadly, Hemant S Murthy, Miguel-Angel Perales, Roy F Chemaly, Christopher E Dandoy, Joshua A Hill, Anna Huppler, Marcie Riches, Jeffery J Auletta

Faculty, Staff and Students Publications

Tisagenlecleucel (tisa-cel) is a CD19-directed chimeric antigen receptor T-cell therapy for relapsed/refractory precursor B-cell acute lymphoblastic leukemia (R/R B-ALL). We report infectious complications for 100 days (D100) following tisa-cel therapy in 471 pediatric and young adults (median age 13.8 years) with R/R B-ALL reported from September 2017 to June 2022. By D100, 137 (29%) patients had an infectious event, with an infection density of 0.542 per 100 person-days at risk. D100 cumulative incidences of bacterial, viral, and fungal infections were 14.1%, 11.6%, and 1.3%, corresponding to infection density scores of 0.296, 0.213, and 0.033 per 100 person-days at risk, respectively. …

Infection After Cd19 Chimeric Antigen Receptor T-Cell Therapy For Large B-Cell Lymphoma: Real-World Analysis From Cibmtr, Kitsada Wudhikarn, Megan M Herr, Min Chen, Michael J Martens, John H Baird, Lohith Gowda, Hemalatha G Rangarajan, Muhammad Bilal Abid, Mohamed A Kharfan-Dabaja, Kirsten M Williams, Siddhartha Ganguly, Jo-Anne H Young, Akshay Sharma, Giancarlo Fatobene, Tania Jain, Christopher G Kanakry, Dipenkumar Modi, Natalie S Grover, Baheyeldin Salem, Marjorie Vieira Batista, Paschalis Vergidis, Dwight E Yin, Amer M Beitinjaneh, Amar H Kelkar, Taiga Nishihori, Jennifer Holter Chakrabarty, Usama Gergis, Melody Smith, Zeinab El Boghdadly, Christopher E Dandoy, Hemant S Murthy, Anna R Huppler, Miguel-Angel Perales, Roy F Chemaly, Joshua A Hill, Marcie Riches, Jeffery J Auletta

Faculty, Staff and Students Publications

Infection is increasingly recognized as a significant cause of morbidity and mortality in patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) receiving CD19 chimeric antigen receptor (CAR) T-cell therapy. The current study analyzed the natural history, risk factors, and outcomes of infection in 3350 patients with R/R LBCL receiving commercial CD19 CAR T-cell therapy (n = 2804 axicabtagene ciloleucel [axi-cel], n = 546 tisagenlecleucel) from December 2017 to June 2022. Infection developed in 834 patients (24.9%) within 100 days after infusion, resulting in an infection density of 0.43 per 100 patient days and a 100-day cumulative incidence of 22%. Bacterial, …

Preclinical Efficacy Of Tasquinimod-Based Combinations In Advanced Myeloproliferative Neoplasms In Blastic Phase, Warren Fiskus, Lucia Masarova, Christopher P Mill, Christine E Birdwell, Kaberi Das, Hanxi Hou, John A Davis, Antrix Jain, Anna Malovannaya, Taghi Manshouri, Andrew Dunbar, Surbhi Sharma, Tapan M Kadia, Courtney D Dinardo, Prithviraj Bose, Naveen Pemmaraju, Sanam Loghavi, Xiaoping Su, Raajit K Rampal, Marie Törngren, Kapil N Bhalla

Faculty, Staff and Students Publications

The alarmins, S100A8 (A8) and S100A9 (A9), are low molecular weight proteins belonging to the S100 protein family. A8 and A9 are secreted into the extracellular space and plasma, in which they interact with Toll-like receptor 4, receptor for advanced glycation end products, and CD33. In these studies, we determined the preclinical efficacy of tasquinimod (TQ) against advanced myeloproliferative neoplasm (MPN) cell lines and patient-derived (PD) CD34+ blastic phase (BP; >5% blasts in the peripheral blood) MPN cells. TQ induced loss of viability in cell lines and PD MPN-BP cells, but not in normal CD34+ progenitor cells. In TQ-treated PD …

Targeted Injection Therapies For Temporomandibular Joint Disorders: A Comparative Review Of Hyaluronic Acid And Botox Techniques, Timothy Alexander, Marissa Siegel, Noah Schnoor, Elizabeth A. Starns

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Purpose: This study aimed to evaluate the effectiveness of different injection therapies for temporomandibular joint disorders (TMD) and answer the research question: how do botulinum toxin (onabotulinumtoxinA, Botox) and hyaluronic acid (HA) injections affect symptoms of temporomandibular joint disorder (TMD)? Methods: An electronic search of three databases was performed using the search terms “Treatment of TMD or TMJ” and one of the following: 1) “Hyaluronic Acid Injection” or 2) “Intramuscular Botox Injection”. Based on studies done with human patients, the effects of both hyaluronic acid and Botox injections as treatments for TMD were observed and analyzed. Inclusion criteria were: full …

Instructors’ Needs For Teaching And Mentoring Undergraduate Students In The Water Sciences, Silvia-Jessica Mostacedo-Marasovic, Kristin Raub, Deanna Mccay, Cory Forbes

Journal of Contemporary Water Research and Education

Undergraduate education in water resources is crucial, involving faculty from diverse disciplines and providing meaningful learning and mentoring experiences. In 2022, the Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI) launched a national survey and organized a virtual collaborative session with respondents to better understand: 1) What are the primary needs faced by faculty members who teach and mentor water science to undergraduate students? and 2) How can academic institutions and external organizations effectively support faculty members in meeting the needs associated with teaching and mentoring water science to undergraduate students? We collected data from N = …

Developmental Effects On Zebrafish Embryos Exposed To Alcohol, Tamya Mchaney

Science University Research Symposium (SURS)

Zebrafish are a good organism model due to their similarities with human biology. The transparency of their embryos allows for an easier view to see the developmental stages of the embryos, and easily and accurately note any mutations or defects in any of the embryos. In addition, they make excellent candidates to track potential effects that mirror human embryos with ethanol and alcohol will have on their developmental stages. The aim of this study was to measure the genetic size developmental differences of the embryo’s lens, eyes, and heart that are given 1% alcohol and 2% alcohol. This study’s experimental …

The Effect Of Leaf Composition And Structure On Decomposition Rates In Primula Sp. And Allium Schoenoparsum, Tatum P. Fortney, Kidist Aklile, Matty Mackay, Solomon Kap

Science University Research Symposium (SURS)

Decomposition is the process by which dead organic matter is broken down by bacteria and fungi. Leaves are a prominent form of organic matter that decomposes and enriches soil by returning nutrients. In this experiment, chive and primrose leaves were investigated. Chive leaves are thinner and softer, while primrose leaves are thicker and more dense, supporting our hypothesis that Chive leaf litter will decompose faster than primrose leaf litter because chives have a lower lignin content and are structurally narrower, making them easier to decompose. For this experiment, we placed around 4 grams of both species into a series of …

Patient Safety In Ambulatory Hysteroscopy, Myko Lanier

Walden Dissertations and Doctoral Studies

NA

Assessing The Role Of Social Media As A Complementary Source In Pharmacovigilance: Insights From Faers, X (Formerly Twitter), And Askapatient Data Across Multiple Drug Classes, Nwanneka Okere

Dissertations

Background: Adverse drug reactions (ADRs) pose significant public health challenges yet remain substantially underreported in traditional pharmacovigilance systems. Social media platforms and patient-reported outcome forums have emerged as potential complementary sources for capturing real-time patient experiences with medications, but their integration with established surveillance systems remains underexplored.

Purpose: This study examined ADR reporting patterns across FDA Adverse Event Reporting System (FAERS), X (formerly Twitter), and Askapatient to evaluate whether patient-generated digital data can complement traditional pharmacovigilance systems for enhanced drug safety monitoring.

Methods: An explanatory sequential mixed-methods design analyzed 107,753 reports representing 289,740 individual ADR occurrences for …

The Effect Of Leaf Composition And Structure On Decomposition Rates In Primula Sp. And Allium Schoenoparsum, Tatum P. Fortney, Darlene Panvini, Kidist Aklile, Matty Mackay, Solomon Kap

Science University Research Symposium (SURS)

Decomposition is the process by which dead organic matter is broken down by bacteria and fungi. Leaves are a prominent form of organic matter that decomposes and enriches soil by returning nutrients. In this experiment, chive and primrose leaves were investigated. Chive leaves are thinner and softer, while primrose leaves are thicker and more dense, supporting our hypothesis that Chive leaf litter will decompose faster than primrose leaf litter because chives have a lower lignin content and are structurally narrower, making them easier to decompose. For this experiment, we placed around 4 grams of both species into a series of …

Evaluating The Effects Of Water Quality And Anthropogenic Disturbance On Salamander Species Diversity, Abundance And Health In Warner Parks, Tatum P. Fortney, Chase Kinsey

Science University Research Symposium (SURS)

Salamanders utilize cutaneous respiration, making them vulnerable to pollution, shifts in water chemistry, and habitat degradation. Increased anthropogenic habitat use may be a detriment to local salamander populations and pollution increases with land use. Understanding how water quality influences salamander abundance, diversity and physiological condition is crucial for amphibian conservation and for assessing freshwater ecosystem health, as they serve as a key bioindicator species. The objective of this study was to examine how variation in water quality parameters influences salamander species abundance, diversity and locomotor performance across stream sites within Warner Parks in Nashville, Tennessee. Field sampling was conducted weekly …

Pd-1 Blockade Induced Bone Loss Occurs In A T-Cell Dependent Manner And May Be Mediated By Ifnγ-Driven Osteoclast Activation, Elena Amonette, Paige M. Hill

Science University Research Symposium (SURS)

PD-1 Blockade Induced Bone Loss Occurs in a T-Cell Dependent Manner and May Be Mediated by IFNγ-Driven Osteoclast Activation

^†Elena Amonette¹, ^†Paige Hill¹, Gwenyth J. Joseph², Rachelle W. Johnson^2,3

¹Belmont University, Nashville, TN; ²Vanderbilt University, Nashville, TN; ³Vanderbilt University Medical Center, Nashville, TN

^†These authors contributed equally to this work

Immune checkpoint inhibitors (ICIs) are becoming increasingly prevalent in the treatment of various cancers due to their ability to reduce tumor mediated T cell death and lengthen the anti-tumor response. One such therapy that is increasingly utilized …

Bonita - Euthynnus Alletteratus Neurocranium, Daniella M. Acosta Reyes, Matthew Mcmanus, Morgan Michalek, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Synthesis And Characterization Of Eco-Engineered Hollow Fe2o3/Carbon Nanocomposite Spheres: Evaluating Structural, Optical, Antibacterial, And Lead Adsorption Properties, Islam Gomaa, Nikita Yushin, Mekki Bayachou, Vojislav Stani´, Inga Zinicovscaia

Chemistry Faculty Publications

This work presents a facile mechano-thermal route for the synthesis of carbon-decorated, hollow, mesoporous alpha-Fe2O3 microspheres. Comprehensive characterization (XRD, XPS, FT-IR, SEM/EDX, TGA, zeta-potential) confirmed the formation of phase-pure hematite with nanoscale crystallites (similar to 19 nm), substantial residual surface carbon (similar to 40 wt%) consistent with Fe-O-C linkages, and a positive surface charge (+15.9 mV). The hierarchical hollow/mesoporous architecture enables fast ion transport and provides extensive interior binding sites, resulting in rapid Pb(II) uptake that reaches 92% removal in approximate to 15 min at pH 5.0. The adsorption follows a Langmuir isotherm (q(max) approximate to 70.6 mg/g) and pseudo-second-order …

Love, Sex, & Aging: Gendered Perspective On Relationship Desires And Satisfaction In Older Adulthood, William Henninger, Melinda Heinz, Nathan Taylor

Faculty Publications

This research explores gender differences in long- and short-term relationships and sexual satisfaction among older adults. Socioemotional Selectivity Theory posits that as people age, they prioritize immediate emotional satisfaction due to perceptions of limited time. This shift influences older adults’ romantic relationships, increasing the likelihood of seeking meaningful connections and reducing the prevalence of negative emotions. With healthy relationships linked to physical, psychological, and financial benefits, research is needed to further understand older adult romantic relationships. Older adults (n = 155) from the Seniors Together in Aging Research (STAR) completed a survey assessing relationship preferences and current and predicted sexual …

Longitudinal Trapping Reveals Differences In Small Mammal Diversity And Community Composition Between Agriculture And Shortgrass Prairie, Trevor Pellerite, Han Li

Biology Faculty Publications

Grasslands in the Great Plains face threats such as agriculture conversion, yet the long-term impacts of this shift on small mammal communities remain underexplored. Using a decade of trapping data from the National Ecological Observatory Network (NEON), we compared small mammal diversity and community composition between a native shortgrass prairie site and an active agricultural site in Colorado, United States. We found no significant difference in species richness between the two habitats; however, the shortgrass prairie exhibited significantly higher diversity. Community composition diverged substantially between sites. The prairie site was characterized by species such as Perognathus flavus, Reithrodontomys megalotis …

In Re Viatris Inc. Securities Litigation

2025 Decisions

USDC for the Western District of Pennsylvania

Overholser Selected As Latterell Visiting Alumnus, Communications And Marketing

Campus News Archive

No abstract provided.

Correcting Class Imbalance Through Synthetic Training Data And 3d Modeling For Carabid Pitfall Trap Sampling, Blair Mirka

Geography ETDs

Crowdsourced biodiversity data provide an accessible foundation for large-scale ecological monitoring, but class imbalance limits automated species identification, particularly for rare taxa. This research explores the use of synthetic training data generated from 3D models of carabid beetle museum specimens to improve detection and classification performance for underrepresented species in crowdsourced datasets. High-resolution 3D models were created to simulate variation in lighting, orientation, and background. These synthetic images were incorporated into convolutional neural network training datasets at varying synthetic-to-real ratios to assess their impact on classification accuracy. Models were evaluated using controlled pitfall-trap imagery to examine the influence of scene …

Locations Of Outfalls In The Indian River Lagoon And Lake Worth Lagoon, Florida, Kelly M. Kibler, Melinda J. Donnelly, Vincent Encomio, Madison Giuntoli, Manisha Thenuwara, Brice Bennett, Laura Andrade Barron, Mariam Sonbol, Wynter Raine Seppala, Namritha Ramakrishnan, Jennifer Jordan Báez, Beth Orlando, Irene Arpayoglou, Melissa Meisenburg

Indian River Lagoon Shorelines

The spatial dataset: UCF_Outfalls_IRL_LWL.shp was created under grants from the Indian River Lagoon National Estuaries Program and Florida Sea Grant. These projects cumulatively led to creation of a living shoreline restoration prioritization model and hydrodynamic habitat suitability models for 1,550 km (963 miles) of estuarine shorelines in Indian River Lagoon (IRL) and Lake Worth Lagoon (LWL).

The dataset presented here includes the location of outfalls identified throughout the study region and general characteristics of the shoreline where they were identified.

Seagrass Persistence In The Indian River Lagoon And Lake Worth Lagoon, Florida, Kelly Kibler, Melinda Donnelly, Vincent Encomio, Madison Giuntoli, Manisha Thenuwara, Brice Bennett, Laura Andrade Barron, Mariam Sonbol, Wynter Raine Seppala, Namritha Ramakrishnan, Jennifer Jordan Báez, Beth Orlando, Irene Arpayoglou, Melissa Meisenburg

Indian River Lagoon Shorelines

The spatial dataset: UCF_seagrasspersistence_IRL_LWL.shp was created with support from the Indian River Lagoon National Estuaries Program and Florida Sea Grant. These projects cumulatively led to creation of a living shoreline restoration prioritization model and hydrodynamic habitat suitability models for 1,550 km (963 miles) of estuarine shorelines in Indian River Lagoon (IRL) and Lake Worth Lagoon (LWL). The dataset presented herein represents persistence of seagrass throughout waters of the IRL and LWL.

The Echo: November 10, 2025, Taylor University

2025-2026 (Volume 113)

No abstract provided.

The Role Of Osteopathic Manipulative Medicine In Cerebral Palsy: Bridging Treatment Gaps And Enhancing Care, Ambrose Loc Ngo, Niki Gharavi Alkhansari, Rachana Tadakamalla, Mercede Hess, Uyen Tam Nguyen, John Yazji, Robert S. Rogers

Student Publications

Osteopathic manipulative medicine (OMM) is a hands-on approach utilized by physicians to diagnose, treat, and prevent various conditions through the application of muscle manipulation techniques. It has been applied in managing chronic musculoskeletal (MSK) pain, headaches, migraines, Parkinsonian gait, and psychological conditions such as stress, anxiety, and depression. In our narrative review, we aim to integrate both direct clinical studies of OMM in cerebral palsy (CP) and supportive literature on mechanisms and related conditions. A comprehensive literature search was conducted utilizing PubMed and Google Scholar to identify relevant studies on OMM in CP management. Search strategies were intentionally broad to …

Intimate Partner Violence: Serving Heterosexual Male And Same-Sex Victims, David Welch

Walden Dissertations and Doctoral Studies

Intimate partner violence (IPV) is an ongoing social problem across nationalities, cultures, socioeconomic statuses, sexual orientations, and genders. Historically, research into IPV has focused on the heterosexual female victim and male perpetrator paradigm, including identifying the root causes of this phenomenon and appropriate treatment models. There is a distinct gap in the current literature addressing how therapists in the psychological community approach working with heterosexual male and same-sex victims of IPV, beginning with case conceptualization. To explore the unique case conceptualization considerations of therapists as they encounter heterosexual male and same-sex IPV victims in their practice, a general phenomenological research …

Tackling The Burden Of Envenomation In Africa: Advances, Challenges, And Strategic Priorities For Enhanced Diagnosis And Treatment, Khawla Ammouch, Nihal Mesmoudi, Noureddine Hammani, Jacob Galan, Abdellah Moustaghfir, Reto Stöcklin, Naoual Oukkache

Human Genetics Publications

Venomous animal envenomation remains a significant but neglected public health problem worldwide, with an estimated 5.4 million cases and up to 138,000 deaths annually. The burden is particularly acute in tropical and subtropical regions, especially sub-Saharan Africa, where rural and vulnerable populations face limited access to effective antivenoms and healthcare. Despite this, comprehensive data on envenomation incidence, clinical management, and outcomes remain scarce, hampering efforts to develop effective prevention and treatment strategies. This review synthesizes current knowledge on venomous animal diversity, epidemiology, and clinical manifestations globally, with a focus on Africa’s unique challenges. We examine critical gaps in antivenom production, …

Nanofiber-Enabled Rapid And Non-Destructive Sensors For Meat Quality And Shelf-Life Monitoring: A Review, Karna Ramachandraiah, Elizabeth M. Martin, Alya Limayem

Food Science Faculty Publications and Presentations

The meat industry faces significant economic losses and environmental impacts due to spoilage and waste, much of which results from inadequate, delayed, or inefficient quality assessment. Traditional methods used for assessing meat quality are often time-consuming, labor-intensive, and lack the ability to provide real-time information, making them insufficient for modern supply chains that demand safety, freshness, and minimal waste. Recent advances in nanotechnology position nanofibers (NFs) as promising materials for addressing these challenges through smart sensing and active packaging. NFs, characterized by their high surface-to-volume ratio, tunable porosity, and small diameter, enable superior encapsulation and immobilization of sensing agents. These …

Chronic Rhinosinusitis Is A Risk Factor For Interstitial Lung Disease In Sjogren’S Syndrome, Brian Schonewald, Christopher Xie, Andrew Engel, Ross Summer, Giorgos Loizidis

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

BACKGROUND: Interstitial lung disease (ILD) is a leading cause of morbidity and mortality in Sjögren's syndrome (SS), but its risk factors remain unclear. Although SS affects both the upper and lower respiratory epithelium, it is unknown whether this occurs simultaneously or separately. In other autoimmune conditions-such as eosinophilic granulomatosis with polyangiitis and granulomatosis with polyangiitis-upper airway disease precedes lower lung involvement by months or even years. We hypothesized that chronic rhinosinusitis (CRS), as an upper airway disease, may be a risk factor for ILD in SS.

METHODS: We analyzed the TriNetX Research Network database to compare incident ILD in SS …

Genome-Wide Crispr Screens Identify Critical Targets To Enhance Car-Nk Cell Antitumor Potency, Alexander Biederstädt, Rafet Basar, Jeong-Min Park, Nadima Uprety, Rejeena Shrestha, Francia Reyes Silva, Merve Dede, John Watts, Sunil Acharya, Donghai Xiong, Bin Liu, May Daher, Hind Rafei, Pinaki Banerjee, Ping Li, Sanjida Islam, Huihui Fan, Mayra Shanley, Jingling Jin, Bijender Kumar, Vernikka Woods, Paul Lin, Silvia Tiberti, Ana Karen Nunez Cortes, Xin Ru Jiang, Inci Biederstädt, Patrick Zhang, Ye Li, Seema Rawal, Enli Liu, Luis Muniz-Feliciano, Gary M Deyter, Elizabeth J Shpall, Natalie Wall Fowlkes, Ken Chen, Katayoun Rezvani

Faculty, Staff and Student Publications

Adoptive cell therapy using engineered natural killer (NK) cells is a promising approach for cancer treatment, with targeted gene editing offering the potential to further enhance their therapeutic efficacy. However, the spectrum of actionable genetic targets to overcome tumor and microenvironment-mediated immunosuppression remains largely unexplored. We performed multiple genome-wide CRISPR screens in primary human NK cells and identified critical checkpoints regulating resistance to immunosuppressive pressures. Ablation of MED12, ARIH2, and CCNC significantly improved NK cell antitumor activity against multiple treatment-refractory human cancers in vitro and in vivo. CRISPR editing augmented both innate and CAR-mediated NK cell function, associated with enhanced …

Whole-Exome Sequencing-Based Linkage Analysis Of Multiple Myeloma (Mm) And Monoclonal Gammopathy Of Undetermined Significance (Mgus) Pedigrees, Alyssa I Clay-Gilmour, Nicola J Camp, Xiaomu Wei, Angel Earle, Aaron Norman, Jason Sinnwell, Delphine Demangel, Rosalie Griffin, Charles Dumontet, James Mckay, Ken Offit, Vijai Joseph, Siwei Chen, Daniel O'Brien, Vincent Rajkumar, Robert Klein, Shaji Kumar, Steve Lipkin, Celine M Vachon

Faculty, Staff and Student Publications

Background/objectives: Family history is a known risk factor for multiple myeloma (MM) and its precursor condition, monoclonal gammopathy of undetermined significance (MGUS). Previous genome-wide association studies (GWASs) have identified 35 common loci associated with MM risk and 21 associated with MGUS. The objective of this study was to identify less common and rare genetic loci predisposing to MM/MGUS through whole-exome sequencing (WES)-based linkage analysis.

Methods: Multipoint linkage analysis was conducted using the Multipoint Engine for Rapid Likelihood Inference (MERLIN) with the Lander-Green algorithm on germline WES data from 79 pedigrees with 2 or more affected relatives (120 MM, 86 MGUS, …

Development Of A Targeted Bioprotac Degrader Selective For Misfolded Sod1, Christen G Chisholm, Rachael Bartlett, Mikayla L Brown, Emma-Jayne Proctor, Natalie E Farrawell, Jody Gorman, Fabien Delerue, Lars M Ittner, Kara L Vine-Perrow, Heath Ecroyd, Neil R Cashman, Darren N Saunders, Luke Mcalary, Jeremy S Lum, Justin J Yerbury

Faculty, Staff and Student Publications

The accumulation of misfolded proteins underlies a broad range of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Due to their dynamic nature, these misfolded proteins have proven challenging to target therapeutically. Here, we specifically target misfolded disease variants of the ALS-associated protein superoxide dismutase 1 (SOD1), using a biological proteolysis targeting chimera (BioPROTAC) composed of a SOD1-specific intrabody and an E3 ubiquitin ligase. Screening of intrabodies and E3 ligases for optimal BioPROTAC construction reveals a candidate capable of degrading multiple disease variants of SOD1, preventing their aggregation in cells. Using CRISPR/Cas9 technology to develop a BioPROTAC transgenic mouse line, we …