Digital Commons Network^™

Breaking The Plateau: Why Nutrition Must Be The Next Frontier In Maternal And Newborn Health, Tamah Kamlem, Ana M. Palacios, Kelly Sullivan, Ousainou Gomez

Eagles Talking About the Public’s Health

No abstract provided.

The New Normal: Breaking Down Paradoxical Changes, Potentially Getting Rid Of Specific Viral Transmission Seasons, And Why You Should Care, Dorothy Seybold, Atin Adhikari

Eagles Talking About the Public’s Health

No abstract provided.

Epigenetic Regulation Of Macrophage-Induced Inflammation By Glutamine During Tissue Repair, Yiting Xu

Yale Graduate School of Arts and Sciences Dissertations

Introduction:

Delayed wound healing is a major healthcare challenge, creating a significant financial burden and impacting patient quality of life by increasing risks of infections, chronic wounds, and impaired tissue regeneration. Macrophages are key mediators in wound healing, where they transition from a pro-inflammatory to an anti-inflammatory state, balancing inflammation resolution and tissue repair. Dysregulated macrophage function, as seen in chronic wounds, leads to persistent inflammation and poor healing outcomes. Recent studies indicate that glutamine metabolism in macrophages may be crucial for this phenotypic transition by influencing gene expression and epigenetic regulation. However, the specific role of glutamine metabolism in …

Parasitism By The Twisted-Winged Parasite Xenos Peckii (Strepsiptera), And Its Effects On The Ovary Development In Their Host Paper Wasp, Polistes Metricus (Hymenoptera), Alex K. Snyder

College of Graduate Studies: Theses & Dissertations

Strepsiptera are generally described as parasitic castrators as they cause the reproductive death of the hosts. In southeast Georgia, only a handful of paper wasps are hosts for twisted-winged parasites. One such species, Polistes metricus, is parasitized by a twisted-winged parasite, Xenos peckii. Previous studies document that host survivorship at most developmental stages was not largely influenced by the presence of X. peckii. To determine if X. peckii can affect their host’s ability to survive and reproduce, we dissected P. metricus to determine ovary development and the presence of X. peckii parasites. Parasite presence had no effect on the host’s …

Investigating Concealments In Infanticide: Incidents And Forensic Entomological Implications, Gillian L. Johnson

College of Graduate Studies: Theses & Dissertations

Forensic entomology plays a critical role in estimating the minimum postmortem interval (mPMIs), based on insect evidence. When victims are concealed, this can complicate mPMI estimates. Utilizing data from the National Violent Death Reporting System (NVDRS) from 2018 to 2021, I found that victims of infanticides and neonaticides are often concealed. I first investigated the demographics of offenders and victims, how often victims are concealed, and the most common means of concealment. I found that victims of infanticide were likely to be concealed 5% of the time, and neonaticides 50% of the time. Next, I investigated how concealment alters insect …

Synthesis And Characterization Of A Biobased Polymer From Tung Oil And Pine Rosin & Characterization Of Polyhydroxybutyrate., Arijanet P. Osumah

College of Graduate Studies: Theses & Dissertations

This thesis presents two independents but thematically aligned research projects focused on the development and evaluation of sustainable polymers. The first involves the synthesis and characterization of a biobased polymer derived from tung oil and pine rosin. Tung oil, which is a triglyceride was chemically modified to produce tung oil diglyceride (TDG), which subsequently reacted with abietic acid-rich pine rosin to yield tung oil abietate (TOA), a biobased monomer. The TOA monomer was polymerized with butyl methacrylate (BMA) and divinylbenzene (DVB) using di-tert-butyl peroxide (DTBP) as a thermal initiator. The resulting polymer was thoroughly characterized using Fourier transform infrared spectroscopy …

Evaluating Impacts Of Footpaths On Resiliency Of Restored Dunes At Tybee Island, Georgia, Skyler J. Fox

College of Graduate Studies: Theses & Dissertations

Sand dunes provide critical ecosystem services including storm protection by acting as natural barriers. However, these systems are threatened by human disturbance, particularly pedestrian traffic occurring at footpaths that damages dune vegetation. Vegetation is essential to dune growth and stability, as dune plants trap and bind sand. When trampled, dunes become more vulnerable to erosion and less effective at providing coastal protection. On Tybee Island, Georgia—a popular tourist destination—a vegetated dune was constructed in 2020 to enhance storm protection. This study assessed how footpaths impact dune resiliency and aimed to inform management strategies. I evaluated: (1) how characteristics of vegetation, …

Assessment And Health Benefit Of Vitamin C Using A549 Cell, Yetunde Adepoju

College of Graduate Studies: Theses & Dissertations

Vitamin C (ascorbic acid) is a vital micronutrient recognized for its antioxidant capacity and essential bodily functions, such as collagen formation, neurotransmitter activity, and regulation of the immune system. This study explores how vitamin C can protect and potentially heal cells under oxidative stress and inflammation, using A549 cells, a human lung epithelial cell line, as the model system. The cells were exposed to varying concentrations of vitamin C dissolved in water, DMSO, and 5% DMSO. To assess the outcome, cell viability was measured with an MTT assay. In addition, the expression of key genes related to oxidative stress and …

Community And Decomposition Dynamics Along A Saltwater Intrusion Gradient On Sapelo Island, Georgia, Zach Gordon

College of Graduate Studies: Theses & Dissertations

Saltwater intrusion, the movement of ocean water into freshwater, is a significant global threat to coastal freshwater ecosystems linked to both climate change and anthropogenic influences. Alterations to coastal landscapes can increase intrusion. Sapelo Island has an extensive history of agricultural landscape alteration, but freshwater flow decline increased the movement of saltwater inland by tides. Intrusion is expected to increase in frequency and magnitude due to rising sea levels and storms. Salinization puts inland habitats and the humans relying on them at risk. As saltwater is denser than freshwater, more pressure is placed on benthic organisms (i.e., macroinvertebrates) that will …

Exploring Coastal Plain Fish Ecology Across A Range Of Early-Life-History Traits And River Types, Bridgette Nicolosi

College of Graduate Studies: Theses & Dissertations

The ecological complexity of southeastern Coastal Plain rivers is reflected in the diversity of fish communities they support, yet the processes structuring early life dynamics remain poorly understood. This thesis explores the influence of environmental gradients on larval fish assemblage composition and American Shad (Alosa sapidissima) spawning phenology across two Georgia Coastal Plain river systems.

In the unregulated Ogeechee River, I investigated spatial and temporal variation in larval fish communities by comparing mainstem and tributary habitats to understand the role of tributaries in watershed-wide larval production. Larvae were collected biweekly from May to September 2024 at eight paired mainstem-tributary sites …

Bringing A Missing Minority Into Focus: Foster Parents’ Voices And Their Impact On Foster Children’S Academic Experiences, Clair Rutherford

College of Graduate Studies: Theses & Dissertations

Foster children face persistent educational inequities shaped by trauma, frequent placement changes, and systemic barrierswithin schools. This dissertation investigates how foster parents perceive and influence the educational experiences of the children in their care, emphasizing the intersection of advocacy, trauma-informed teaching, and institutional response. Grounded in trauma-informed pedagogy, critical ecology and curriculum studies, the study interrogates how schools both support and constrain foster children’s educational opportunities. An arts-based methodology was employed, combining fictionalized portraiture and digital ethnography. Data sources included foster parent social media posts, reflexive journalling, and researcher positionality as both teacher and foster parent. Composite narratives were constructed …

Artificial Intelligence In Science And Society: The Vision Of Usern, Tommaso Dorigo, Gary D. Brown, Carlo Casonato, Artemi Cerda, Joseph Ciarrochi, Mauro Da Lio, Nicole D'Souza, Nicolas R. Gauger, Steven C. Hayes, Stefan G. Hofmann, Robert Johansson, Marcus Liwicki, Fabien Lotte, Juan J. Nieto, Giulia Olivato, Peter Parnes, George Perry, Alice Plebe, Idupulapati M. Rao, Nima Rezaei, Fredrik Sandin, Andrey Ustyuzhanin, Giorgio Vallortigara, Pietro Vischia, Niloufar Yazdanpanah

All Peer-Reviewed Publications

The recent rise in relevance and diffusion of Artificial Intelligence (AI)-based systems and the increasing number and power of applications of AI methods invites a profound reflection on the impact of these innovative systems on scientific research and society at large. The Universal Scientific Education and Research Network (USERN), an organization that promotes initiatives to support interdisciplinary science and education across borders and actively works to improve science policy, collects here the vision of its Advisory Board members, together with a selection of AI experts, to summarize how we see developments in this exciting technology impacting science and society in …

Biological Control Of Ticks In Domestic Environments: Modeling The Potential Impact Of Entomopathogenic Fungi On The Transmission Of East Coast Fever In Cattle, Joseph Wang Ang A. Oundo, Nienke Hartemink, Mart C.M. De Jong, Constantianus J.M. Koenraadt, Shewit Kalayou, Daniel Masiga, Quirine Ten Bosch

All Peer-Reviewed Publications

Biological control of ticks using entomopathogenic fungi (EPF) is a highly desired alternative to chemical acaricides for the control of tick-borne pathogens. For Metarhizium anisopliae isolate ICIPE 7, one of these EPFs, efficacy against multiple tick species has been demonstrated in laboratory and field settings. However, we currently have little quantitative understanding of how EPFs can impact transmission. We developed a deterministic model of tick–host–pathogen interactions to explore how the effects of EPF on Rhipicephalus appendiculatus ticks may impact the transmission dynamics of East Coast fever (ECF) in cattle populations. We parameterized the multi-faceted effects of EPFs on tick dynamics …

Consequences Of Fire And Grazing To Conservation Of Arthropod Functional Diversity In A Protected Afrotropical Savanna, Ludzula Mukwevho, Tatenda Dalu, Mduduzi Ndlovu, Frank Chidawanyika

All Peer-Reviewed Publications

Fires and grazing disrupt the diversity and composition of biological organisms and their functions in the savannas. In the current study, we assessed the impact of fire and grazing intensities on the abundance, species richness and assemblages of eight functional groups of arthropods in Kruger National Park. Pitfalls and active searches were used to collect arthropods at the experimental burnt plots (EBPs) and grazed plots that were undisturbed, minimally or heavily disturbed in Mopane and Skukuza regions. Omnivores constituted the highest proportion (40 %) of individuals, whilst detritivores, granivores, hematophagous, herbivores, nectarivores, predators and scavengers constituted between 0.5 % and …

Challenges And Lessons From A Vector Control Campaign Targeting Glossina Palpalis Palpalis In An Isolated Protected Forest Area In Abidjan, Côte D’Ivoire, Yao Jean Rodrigue Konan, Bi Tra Dieudonné Ta, Djakaridja Berté, Bamoro Coulibaly, Kinifo Donatien Coulibaly, Nick Steven Egnankon, Foungniguée Diarrassouba, Kouassi Albert Djabo, Stéphanie Watier-Grillot, Jean Paul Demoncheaux, Koffi Alain De Marie Kouadio, Louis N’Dri, Philippe Solano, Sophie Ravel, Guy Pacôme Adingra, Antoine Barreaux, Adeline Ségard, Dramane Kaba, Vincent Jamonneau, Thierry De Meeûs, Vincent Djohan

All Peer-Reviewed Publications

Vector control (VC) is one of the strategies employed to manage African trypanosomoses. This study aimed at assessing the effectiveness of a VC campaign against Glossina palpalis palpalis using tiny targets (TTs) impregnated with insecticide in an isolated, protected forest in Abidjan, Côte d’Ivoire, while considering ecological, genetic, and operational factors. Between January 2020 and September 2022, 2,712 TTs were deployed at 684 sites, covering a total area of 1.7 km2. VC monitoring was conducted using Vavoua traps during 12 evaluation surveys, between June 2020 and March 2023. Five months after the initial TT deployment, tsetse fly density had decreased …

Aflatoxin Prevalence And Association With Maize Grain Physical And Nutritional Qualities In The Informal Markets In Meru County, Kenya, C. Cherotich, M. W. Okoth, Abong’ Go, S. W. Kariuki, E. R. Omuse

All Peer-Reviewed Publications

In Kenya, aflatoxin contamination in maize remains a persistent issue, with potential negative impacts on both public health and economic growth. Aflatoxins are toxic secondary metabolites produced by certain mold species, primarily Aspergillus flavus. The extent of Aspergillus fungal invasion in maize grains and the resulting increase in aflatoxin levels is heavily influenced by pre-and post-harvest practices. Before harvest, factors such as insect damage and exposure to warm, humid conditions increase the crop's susceptibility to Aspergillus infection and subsequent aflatoxin formation. Post-harvest, additional risks arise when kernels are damaged by pests like rats or when they are stored in unfavorable …

Global Strategies To Manage Huanglongbing (Hlb) And Its Vectors: Insights And Implications For The Mediterranean Region, Meritxell Pérez-Hedo, Mark S. Hoddle, Fernando Alferez, Lochy Batista, George A.C. Beattie, Shourish Chakravarty, Paul Holford, Fathiya Mbarak Khamis, Inusa Jacob Ajene, Aruna Manrakhan, Paul H. Fourie, Maritza Luis, Eduardo Osorio-Hernández, Mamoudou Sétamou, Alejandro Tena, Pedro Takao Yamamoto, Tara Wade, Changyong Zhou, Nian Wang, Lukasz L. Stelinski, Alberto Urbaneja

All Peer-Reviewed Publications

Huanglongbing (HLB), also known as citrus greening disease, poses a severe threat to the global citrus industry. This disease is caused by three species of bacteria, ‘Candidatus Liberibacter asiaticus’, ‘C. L. africanus’, and ‘C. L. ameri-canus’. The primary pathogen vectors are the Asian citrus psyllid (Diaphorina citri Kuwayama, Hemiptera: Psyllidae) and the African citrus psyllid (Trioza erytreae Del Guercio, Hemiptera: Triozidae). The disease is incurable, and its management relies on reducing vector densities and the adverse effects of bacterial infections on host trees. Managing psyllid vec-tors, especially D. citri, has proven exceptionally challenging due to its rapid spread and subsequent …

How Do People Change Their Beliefs About Climate Change? A Qualitative Study On Opinion Shift In The U.S. Midwest, Emily A. Hurley, Michael S. Molloy

Manuscripts, Articles, Book Chapters and Other Papers

Beliefs and attitudes about climate change are the building blocks from which humans create and support mitigation and adaptation strategies. In the United States, 72% of the public now believes that the earth is warming and 58% believe humans are the cause. Although these figures represent some increase since 2010, they also represent a significant remaining gap in acceptance of climate change realties. While a wealth of research has identified isolated factors that influence opinions on climate change, less attention has been given to understanding the process that changes people’s opinions. Our study uniquely applies qualitative methods to examine the …

Psychometric Evaluation Of A Novel Measure Of Trauma-Related Cannabis Use To Cope, Sage E. Hawn, Terrell A. Hicks, Christopher Latourrette, Anita Thomas, Daniela Chaname, Sarah Ehlke, Abigail Powers Lott

Psychology Faculty Publications

Background: Posttraumatic stress disorder (PTSD) and cannabis use disorder (CUD) are commonly comorbid and are associated with many negative public health outcomes. One plausible explanation for this comorbidity comes from a self-medication framework, which suggests people use cannabis to cope with PTSD symptoms. Despite theoretical and empirical evidence for PTSD-related cannabis use to cope, no measure of this construct exists.

Objective: We sought to address this gap by developing and validating a novel measure of PTSD-specific cannabis self-medication, which we have termed the Trauma-Related Cannabis Use to Cope (TRCU) questionnaire.

Method: The psychometric properties of the TRCU and how it …

Vagally Mediated Heart Rate Variability Modulates The Association Between The Perceived Workload And The Stroop Effect On Behavioral Performance, Xiao Yang, Michael Gazzanigo, Fang Fang, Spencer House

Psychology Faculty Publications

Vagally mediated heart rate variability (vmHRV) reflects top-down cognitive processes involved in emotion-cognition integration. Using cognitive control can be effortful and increase negative affect. However, this intrinsic affective component of cognitive control has not been well studied, and the role of vmHRV in the association between subjective experience in using cognitive control and behavioral performance remains unknown. The current study aimed to examine the relationship of vmHRV with cognitive control and perceived workload in a cognitive task. Eighty-one participants performed the Stroop interference task. Participants rated subjective workload using the NASA Task Load Index (NASA-TLX) scale for congruent and incongruent …

Parent Ptsd, Social Support And Differential Associations With Facets Of Anxiety Sensitivity, Kristen Bermingham, Christopher Latourrette, Karen G. Chartier, Spit For Science Working Group, Ananda B. Amstadter, Kaitlin Bountress

Psychology Faculty Publications

Background: Anxiety Sensitivity (AS), the belief that anxiety experiences have negative implications, is a prospective predictor of posttraumatic stress disorder (PTSD) and has been linked to changes in PTSD in experimental studies. AS is comprised of three sub-components: cognitive, physical, and social concerns. PTSD is moderately heritable and parental PTSD may increase risk for these AS facets both directly and through environmental influences like reduced social support.

Objective: The present study will examine whether Parent PTSD is associated with reduced social support and in turn facets of AS.

Method: Participants were recruited from an ongoing longitudinal study of college student …

Disappearing Data At The U.S. Federal Government, Janet W. Freilich, Nicholson Price Ii, Aaron S. Kesselheim

Other Publications

Health data hosted by the U.S. federal government have been disappearing. According to our analysis, between January 21 and February 11, 2025, the Centers for Disease Control and Prevention (CDC) removed 203 datasets (13% of its online datasets, a reduction from 1519 to 1316). The situation is dynamic; various datasets have been removed, restored, manipulated, or not posted as planned.

Physiologic And Structural Characterization Of Desisobutyryl-Ciclesonide, A Selective Glucocorticoid Receptor Modulator In Newborn Rats., Juliann D. Jaumotte, Nathalie El Khoury, Charles K. Min, Jiefei Wang, Caroline Madigan, Antalya Jano, Robin J. Russo Kobylski, Laura A. Solt, Rutu S. Dhavan, Kelly L. Short, Tianhua Lei, Uma Chandran, Timothy J. Cole, Ann Paula Monaghan-Nichols, Venkatesh Sampath, René Houtman, Kendall W. Nettles, Donald B. Defranco

Manuscripts, Articles, Book Chapters and Other Papers

Bronchopulmonary dysplasia, the most prevalent chronic lung disease of prematurity, is often treated with glucocorticoids (GCs) such as dexamethasone (DEX), but their use is encumbered with several adverse somatic, metabolic, and neurologic effects. We previously reported that systemic delivery of the GC prodrug ciclesonide (CIC) in neonatal rats activated glucocorticoid receptor (GR) transcriptional responses in lung but did not trigger multiple adverse effects caused by DEX. To determine whether limited systemic metabolism of CIC was solely responsible for its enhanced safety profile, we treated neonatal rats with its active metabolite desisobutyryl-ciclesonide (Des-CIC). DEX but not Des-CIC caused a reduction in …

Emerging Role Of Sh3bp2 As Regulator Of Immune And Nonimmune Cells In Nephrotic Syndrome., Tarak Srivastava, Mukut Sharma

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are major forms of nephrotic syndrome that remain difficult to treat. MCD and FSGS have distinct but also overlapping clinical, histological, metabolic, and molecular features. Effective use of immunosuppressive drugs, activated immune cells, altered cytokine profiles, and upregulated signaling pathways suggest a link between immune dysfunction and nephrotic syndrome, but the exact mechanism of immunopathogenesis is unclear. Immune dysfunction is an area of ongoing research for identifying novel molecular targets for treating nephrotic syndrome. However, the available animal models do not directly address the role of immune dysfunction in nephrotic …

Chironomids Shed Light On Organic Matter Dynamics In Macroinvertebrate Communities In Prairie Pothole Lakes In West-Central Minnesota, Usa, Tracey M. Anderson, Sarah G. Winikoff, Michael L. Sorensen, Melissa L. Rudeen

Biology Publications

The Prairie Pothole Region (PPR) in North America is characterized by a high density of wetlands that can range from temporary habitats to small lakes. Much of the PPR has been converted to agriculture resulting in outright habitat loss, eutrophication, sedimentation, introduction of agrochemicals, and the introduction of invasive plants and animals. We compared two prairie pothole lakes, Cottonwood Lake and Page Lake, to assess the functional roles and trophic structure of the macroinvertebrate communities in this highly altered landscape. We collected macroinvertebrate samples from littoral and profundal regions of each lake with an Ekman grab sampler in winters of …

Automation To Autonomy: Temporal Dynamics Of Trust And Visual Attention Allocation Did Not Evolve, Tetsuya Sato, Eric Chancey, Yusuke Yamani

Psychology Faculty Publications

Emerging work environments are expected to implement autonomy that performs various functions without human input. Previous works has shown that trust in automation is negatively correlated with visual attention allocation, indicating that trust is a dynamic construct. Moreover, trust in automation and trust in autonomy appears to evolve in similar ways. However, recent work has demonstrated differences between trust in automation and trust in autonomy within Kaber’s (2018) theoretical framework (Sato et al., 2023b). Yet, it is uncertain whether the development of trust and visual attention allocation differs between automation and autonomy. The present study examined the temporal dynamics of …

Drinking Motives And Alcohol Sensitivity Mediate Multidimensional Genetic Influences On Alcohol Use Behaviors, Jeanne E. Savage, Spit For Science Working Group, Danielle M. Dick

Psychology Faculty Publications

Background

Genetic influences account for a substantial proportion of individual differences in alcohol use behaviors (AUBs). However, multiple distinct sets of genes are linked to different AUBs via uncertain causal links. Here, we explore whether intermediate neurobiological traits mediate the relationship between polygenic scores (PGSs) and multiple AUBs, with the aim to better understand processes captured by different genetic profiles.

Methods

We derived four alcohol-related PGSs in participants from Spit for Science, a longitudinal study of college students in the United States (n=4549). Using linear regression, we tested the relationship between PGSs and 22 potential mediators, including personality, …

Sustainable Agricultural Alternatives To Cope With Drought Effects In Semi-Arid Areas Of Southern Mozambique: Review And Strategies Proposal, Celso Mondlhane, Lawrence Munjonji, Íris Victorino, Carlos Huenchuleo, Paula Pimentel, Pablo Cornejo

All Grantees Publications

Drought, pests, soil fertility depletion, environmental challenges, and the limited use of agricultural inputs continue to plague food production in many developing countries such as Mozambique. As a response to these production constraints, sustainable strategies must be defined to cope with these problems. One strategy, largely applied worldwide, is the combination of the usage of plant growth-promoting microorganisms, conservation tillage, intercropping, and crop residue management. The above can help smallholder farmers to become more resilient, sustainable, and productive, in a framework where the limitations imposed by global climate change are being exacerbated. The impacts of these strategies are less known …

Preparation And Characterization Of Clay Soils For Applications In Cyanide Removal From Mining Wastewater, Raymond Kaboré, Yacouba Sanou, Rasmane Tiendrebéogo, Alassane Compaoré, Adama Konaté, Samuel Paré

Minerals, Mining and Materials Engineering

In Burkina Faso, waterresourcesin mining areas are polluted by cyanide, which is released into the environment through mining activities. To mitigate this pollution, two clays named Koro and Kaya were collected in Burkina Faso and characterized using analytical technics. This work aimed to find out a cheap technology based on local soils for water treatment. The objective of the work was to prepare and characterize two local clays for application in mining effluent treatment. Specific surface area and pore dimensions were analyzed using Brunauer, Emmett and Teller method. In addition, anion exchange capacities, chemical composition through X-ray fluorescence and chemical …

Photocatalytic Remediation Of Selected Emerging Organic Pollutants In Industrial Effluent Using Conducting Polymeric-Based Nanocomposites Photocatalysts -A Review, Joshua Akinropo Oyetade, Kolajo Oluwafemi, Vanessa N.K Hammond, Angela Boateng, Revocatus Lazaro Machunda, Askwar Hilonga

Minerals, Mining and Materials Engineering

Emerging organic pollutants in industrial effluents pose huge environmental and health challenges, with conventional effluent treatment methods often insufficient for effective abatement of these toxic pollutants. This is the rationale behind the need for the development of a novel class of photocatalysts known as conducting polymeric-based nanocomposites for proficient photocatalytic remediation of these pollutants. The pollutants of interest in this review are the pharmaceutically active compounds (PhACs), pesticides and per- and polyfluoroalkyl substances (PFAS) with appreciable presence in industrial wastewater. The review comparatively reported various state-of-the-art engineering approaches for the fabrication of this class of nanocomposite photocatalysts with well-tailored properties …